diiodine - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	diiodine	go back to main search page
Accession:	CHEBI:17606	browse the term
Definition:	Molecule comprising two covalently bonded iodine atoms with overall zero charge..
Synonyms:	related_synonym:	Formula=I2; I2; InChI=1S/I2/c1-2; InChIKey=PNDPGZBMCMUPRI-UHFFFAOYSA-N; Iodine; Jod; SMILES=II; molecular iodine
	alt_id:	CHEBI:14461; CHEBI:5947
	xref:	Beilstein:3587194; CAS:7553-56-2; Drug_Central:4446; Gmelin:1160; KEGG:C01382; KEGG:D00108
	xref_mesh:	MESH:D007455
	xref:	PMID:15206581; PMID:19672279; PMID:20045605; PMID:24504625

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Rat (241 ) Mouse (254 ) Human (246 ) Chinchilla (0 ) Bonobo (0 ) Dog (0 ) Squirrel (0 ) Pig (0 ) Green Monkey (0) Naked Mole-rat (0 ) All
Genes (241)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 4

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of ABCA4 mRNA

NCBI chr 2:210,164,813...210,302,069
Ensembl chr 2:210,164,813...210,302,069

G

ATP binding cassette subfamily C member 6

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of ABCC6 mRNA

NCBI chr 1:105,583,681...105,637,895
Ensembl chr 1:96,447,251...96,501,464

G

acyl-CoA oxidase 2

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of ACOX2 mRNA

NCBI chr15:16,660,584...16,692,160
Ensembl chr15:16,660,272...16,692,160

G

actin alpha 2, smooth muscle

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of ACTA2 mRNA

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554

G

ADAM metallopeptidase with thrombospondin type 1 motif, 19

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in increased expression of ADAMTS19 mRNA

NCBI chr18:52,346,448...52,531,245
Ensembl chr18:52,347,428...52,530,509

G

adrenoceptor beta 3

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of ADRB3 mRNA

NCBI chr16:71,544,603...71,547,410
Ensembl chr16:64,841,788...64,844,552

G

aldehyde dehydrogenase 1 family, member A1

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of ALDH1A1 mRNA

NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:218,042,127...218,152,961

G

aldehyde dehydrogenase 1 family, member L1

multiple interactions

EXP

[Iodine deficiency co-treated with sodium perchlorate] results in decreased expression of ALDH1L1 protein

NCBI chr 4:123,059,989...123,106,471
Ensembl chr 4:123,060,008...123,106,465

G

aldehyde dehydrogenase 5 family, member A1

multiple interactions

EXP

[Iodine deficiency co-treated with sodium perchlorate] results in decreased expression of ALDH5A1 protein

NCBI chr17:40,132,339...40,158,677
Ensembl chr17:40,130,883...40,158,677

G

angiopoietin-like 2

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of ANGPTL2 mRNA

NCBI chr 3:16,517,185...16,547,024
Ensembl chr 3:16,517,420...16,548,178

G

annexin A8

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in increased expression of ANXA8 mRNA

NCBI chr16:9,397,144...9,412,072
Ensembl chr16:9,397,113...9,412,043

G

apolipoprotein B mRNA editing enzyme catalytic subunit 1

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of APOBEC1 mRNA

NCBI chr 4:157,472,879...157,500,496
Ensembl chr 4:155,800,887...155,827,390

G

aquaporin 1

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of AQP1 mRNA

NCBI chr 4:85,812,784...85,824,964
Ensembl chr 4:84,482,512...84,494,690

G

ADP-ribosyltransferase 3

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of ART3 mRNA

NCBI chr14:15,637,230...15,719,442
Ensembl chr14:15,637,237...15,665,407

G

BCL2 associated X, apoptosis regulator

multiple interactions

ISO

[Diatrizoate co-treated with Iodine] results in increased expression of BAX protein

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions

ISO

[Diatrizoate co-treated with Iodine] results in increased expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

C1q and TNF related 2

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of C1QTNF2 mRNA

NCBI chr10:27,941,948...27,958,926
Ensembl chr10:27,941,948...27,959,185

G

calmodulin-like 4

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of CALML4 mRNA

NCBI chr 8:63,323,426...63,335,234
Ensembl chr 8:63,323,351...63,335,234

G

caspase 3

multiple interactions

ISO

[Diatrizoate co-treated with Iodine] results in increased activity of CASP3 protein

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

carbonyl reductase 2

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of CBR2 mRNA

NCBI chr10:106,008,535...106,012,838
Ensembl chr10:105,991,589...106,013,001

G

cholecystokinin

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of CCK mRNA

NCBI chr 8:130,031,012...130,037,702
Ensembl chr 8:121,153,500...121,160,084

G

C-C motif chemokine ligand 28

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in increased expression of CCL28 mRNA

NCBI chr 2:51,601,354...51,625,999
Ensembl chr 2:51,601,331...51,625,997

G

C-C motif chemokine ligand 3

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in increased expression of CCL3 mRNA

NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,451,388...68,452,938

G

cellular communication network factor 2

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of CCN2 mRNA

NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:20,802,199...20,805,734

G

CD274 molecule

increases expression
multiple interactions

ISO

Iodine results in increased expression of CD274 mRNA
CD274 protein affects the reaction [Iodine results in increased expression of PDCD1 mRNA]; CD274 protein affects the reaction [Iodine results in increased expression of PDCD1 protein]; CD274 protein affects the reaction [Iodine results in increased expression of PDCD1LG2 mRNA]

NCBI chr 1:236,526,215...236,549,956
Ensembl chr 1:227,116,649...227,134,450

G

CD79a molecule

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of CD79A mRNA

NCBI chr 1:89,621,460...89,625,813
Ensembl chr 1:80,493,581...80,497,935

G

CD86 molecule

increases expression

EXP

Iodine results in increased expression of CD86 mRNA

NCBI chr11:77,647,565...77,706,178
Ensembl chr11:64,163,828...64,200,818

G

cadherin-related 23

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in increased expression of CDH23 mRNA

NCBI chr20:28,240,643...28,622,490
Ensembl chr20:28,240,645...28,622,419

G

cadherin 3

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of CDH3 mRNA

NCBI chr19:51,303,414...51,353,900
Ensembl chr19:34,393,727...34,444,084

G

cyclin-dependent kinase 5 regulatory subunit 1

decreases expression

EXP

Iodine deficiency results in decreased expression of CDK5R1 protein

NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456

G

CEA cell adhesion molecule 4

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in increased expression of CEACAM10 mRNA

NCBI chr 1:80,376,667...80,382,943
Ensembl chr 1:80,376,648...80,382,915

G

CBY1 interacting BAR domain containing 2

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of FAM92B mRNA

NCBI chr19:48,217,617...48,229,418
Ensembl chr19:48,215,486...48,229,404

G

ciliary microtubule inner protein 2C

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of FAM166C mRNA

NCBI chr 6:25,905,294...25,923,615
Ensembl chr 6:25,905,294...25,923,615

G

chloride voltage-gated channel 5

increases abundance
increases uptake

ISO

CLCN5 gene mutant form results in increased abundance of Iodine
CLCN5 gene mutant form results in increased uptake of Iodine

NCBI chr X:17,857,260...18,011,844
Ensembl chr X:15,185,451...15,334,264

G

claudin 2

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of CLDN2 mRNA

NCBI chr X:108,248,383...108,258,847
Ensembl chr X:103,459,780...103,474,838

G

claudin 5

multiple interactions

ISO

[gamma-Linolenic Acid co-treated with Iodine co-treated with Selenium] results in increased expression of and results in increased localization of CLDN5 protein; [gamma-Linolenic Acid co-treated with Iodine] results in increased expression of and results in increased localization of CLDN5 protein; [Selenium co-treated with Iodine] results in increased expression of and results in increased localization of CLDN5 protein; Iodine results in increased expression of and results in increased localization of CLDN5 protein

NCBI chr11:95,717,172...95,718,598
Ensembl chr11:82,211,475...82,214,992

G

C-type lectin domain containing 7A

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in increased expression of CLEC7A mRNA

NCBI chr 4:162,902,731...162,913,931
Ensembl chr 4:162,902,732...162,913,897

G

collagen type I alpha 1 chain

increases expression

ISO

Iodine results in increased expression of COL1A1 mRNA

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624

G

collagen type XXIV alpha 1 chain

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of COL24A1 mRNA

NCBI chr 2:234,212,256...234,469,445
Ensembl chr 2:234,212,324...234,469,441

G

collagen type IV alpha 3 chain

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of COL4A3 mRNA

NCBI chr 9:83,875,849...84,004,955
Ensembl chr 9:83,875,561...84,001,895

G

collagen type VIII alpha 1 chain

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of COL8A1 mRNA

NCBI chr11:42,776,851...42,906,432
Ensembl chr11:42,777,628...42,906,424

G

collagen like tail subunit of asymmetric acetylcholinesterase

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in increased expression of COLQ mRNA

NCBI chr16:6,731,850...6,824,973
Ensembl chr16:6,731,858...6,787,107

G

cortistatin

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of CORT mRNA

NCBI chr 5:159,560,591...159,562,032

G

complexin 3

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of CPLX3 mRNA

NCBI chr 8:58,003,535...58,010,297
Ensembl chr 8:58,003,535...58,010,297

G

carboxypeptidase Z

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of CPZ mRNA

NCBI chr14:75,223,692...75,246,946
Ensembl chr14:75,223,605...75,246,945

G

corticotropin releasing hormone receptor 2

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in increased expression of CRHR2 mRNA

NCBI chr 4:84,222,897...84,265,924
Ensembl chr 4:84,224,002...84,265,904

G

crystallin, gamma N

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of CRYGN mRNA

NCBI chr 4:10,394,015...10,401,542
Ensembl chr 4:10,394,020...10,401,543

G

cystathionine gamma-lyase

multiple interactions

EXP

[Iodine deficiency co-treated with sodium perchlorate] results in decreased expression of CTH protein

NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234

G

cell wall biogenesis 43 C-terminal homolog

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of CWH43 mRNA

NCBI chr14:34,754,279...34,800,530
Ensembl chr14:34,754,289...34,800,814

G

cytochrome b5 type A

multiple interactions

EXP

[[Iodine deficiency co-treated with sodium perchlorate] affects the susceptibility to hexabromocyclododecane] which results in decreased expression of CYB5A protein

NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535
Ensembl chr18:78,202,342...78,258,535

G

cytochrome P450, family 11, subfamily a, polypeptide 1

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of CYP11A1 mRNA

NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 19, subfamily a, polypeptide 1

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of CYP19A1 mRNA

NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 2, subfamily b, polypeptide 3

multiple interactions

ISO

[Iodine deficiency co-treated with Propylthiouracil] results in increased expression of CYP2B10 mRNA

NCBI chr 1:90,780,468...90,859,852
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 2, subfamily f, polypeptide 4

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of CYP2F2 mRNA

NCBI chr 1:91,543,768...91,557,553
Ensembl chr 1:82,416,130...82,429,896

G

DEPP autophagy regulator 1

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of DEPP1 mRNA

NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542

G

iodothyronine deiodinase 1

decreases activity
decreases expression
multiple interactions
increases expression

ISO
EXP

Iodine results in decreased activity of DIO1 protein
Iodine results in decreased expression of DIO1 mRNA
Selenium inhibits the reaction [Iodine results in decreased activity of DIO1 protein]; Selenium inhibits the reaction [Iodine results in decreased expression of DIO1 mRNA]
Iodine results in increased expression of DIO1 mRNA
Methylnitrosourea inhibits the reaction [Iodine results in increased expression of DIO1 mRNA]

PMID:15922087 PMID:17044649

NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970

G

iodothyronine deiodinase 3

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of DIO3 mRNA

NCBI chr 6:135,107,072...135,108,933
Ensembl chr 6:129,285,749...129,286,660

G

DIO3 opposite strand upstream RNA

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of DIO3OS mRNA

G

deleted in malignant brain tumors 1 like 1

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of CDCP3 mRNA

NCBI chr 1:185,949,897...186,084,340
Ensembl chr 1:185,949,881...186,084,338

G

dermokine

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of DMKN mRNA

NCBI chr 1:86,013,237...86,031,243
Ensembl chr 1:86,014,188...86,030,006

G

doublesex and mab-3 related transcription factor 2

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of DMRT2 mRNA

NCBI chr 1:223,317,543...223,324,131
Ensembl chr 1:223,317,642...223,324,131

G

dopamine receptor D3

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of DRD3 mRNA

NCBI chr11:70,385,586...70,437,793
Ensembl chr11:56,879,689...56,940,596

G

desmocollin 3

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of DSC3 mRNA

NCBI chr18:11,379,759...11,413,797
Ensembl chr18:11,377,347...11,413,797

G

death domain containing 1

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of DTHD1 mRNA

NCBI chr14:46,670,438...46,673,183

G

EDAR associated via death domain

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in increased expression of EDARADD mRNA

NCBI chr17:85,866,629...85,910,612
Ensembl chr17:85,656,905...85,910,447

G

endothelin 3

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of EDN3 mRNA

NCBI chr 3:183,980,458...184,004,958
Ensembl chr 3:163,562,520...163,585,093

G

empty spiracles homeobox 1

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of EMX1 mRNA

NCBI chr 4:117,725,148...117,741,616
Ensembl chr 4:117,725,155...117,741,613

G

ectonucleotide pyrophosphatase/phosphodiesterase 2

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of ENPP2 mRNA

NCBI chr 7:88,092,140...88,214,758
Ensembl chr 7:86,202,350...86,324,827

G

epsin 3

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of EPN3 mRNA

NCBI chr10:79,438,978...79,449,516
Ensembl chr10:79,438,978...79,447,356

G

coagulation factor V

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of F5 mRNA

NCBI chr13:79,046,657...79,116,247
Ensembl chr13:76,513,255...76,582,317

G

family with sequence similarity 180, member A

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of FAM180A mRNA

NCBI chr 4:63,992,867...64,008,047
Ensembl chr 4:63,992,867...64,008,047

G

fibroblast activation protein, alpha

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of FAP mRNA

NCBI chr 3:47,138,823...47,207,671
Ensembl chr 3:47,138,813...47,225,545

G

FAT atypical cadherin 2

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of FAT2 mRNA

NCBI chr10:39,364,072...39,456,324
Ensembl chr10:39,364,073...39,456,216

G

fibrillin 2

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in increased expression of FBN2 mRNA

NCBI chr18:53,696,197...53,901,992
Ensembl chr18:51,499,737...51,703,976

G

F-box and leucine-rich repeat protein 22

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of FBXL22 mRNA

NCBI chr 8:67,069,998...67,076,685
Ensembl chr 8:67,069,998...67,076,685

G

Fez family zinc finger 2

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of FEZF2 mRNA

NCBI chr15:12,768,614...12,777,554
Ensembl chr15:12,773,762...12,777,554

G

fibroblast growth factor 7

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of FGF7 mRNA

NCBI chr 3:133,734,557...133,786,678
Ensembl chr 3:113,281,283...113,332,929

G

folate receptor alpha

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of FOLR1 mRNA

NCBI chr 1:156,219,460...156,238,436
Ensembl chr 1:156,219,460...156,230,667

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions

EXP

Iodine results in increased expression of FOS mRNA; Iodine results in increased expression of FOS protein
[Selenium co-treated with Iodine] results in increased expression of FOS mRNA; [Selenium co-treated with Iodine] results in increased expression of FOS protein

PMID:12475444 PMID:12666833

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036

G

FERM domain containing 7

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in increased expression of FRMD7 mRNA

NCBI chr X:130,375,925...130,423,836
Ensembl chr X:130,377,227...130,423,771

G

formimidoyltransferase cyclodeaminase

multiple interactions

EXP

[[Iodine deficiency co-treated with sodium perchlorate] affects the susceptibility to hexabromocyclododecane] which results in decreased expression of FTCD protein

NCBI chr20:12,055,203...12,068,717
Ensembl chr20:12,055,208...12,068,735

G

guanidinoacetate N-methyltransferase

multiple interactions

EXP

[[Iodine deficiency co-treated with sodium perchlorate] affects the susceptibility to hexabromocyclododecane] which results in increased expression of GAMT protein

NCBI chr 7:9,448,590...9,451,413
Ensembl chr 7:9,448,628...9,451,778

G

guanylate binding protein 4

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of GBP3 mRNA

NCBI chr 2:231,304,910...231,318,883
Ensembl chr 2:231,305,244...231,318,879

G

gap junction protein, beta 6

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of GJB6 mRNA

NCBI chr15:35,400,147...35,410,649
Ensembl chr15:31,284,419...31,294,582

G

gastrokine 3

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of GKN3 mRNA

NCBI chr 4:119,828,859...119,833,924
Ensembl chr 4:119,829,005...119,834,842

G

GLI family zinc finger 1

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of GLI1 mRNA

NCBI chr 7:65,042,237...65,054,888
Ensembl chr 7:63,156,926...63,169,251

G

glutaminase 2

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of GLS2 mRNA

NCBI chr 7:617,252...633,424
Ensembl chr 7:617,288...633,426

G

glycophorin A

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of GYPA mRNA

NCBI chr19:27,450,304...27,465,940
Ensembl chr19:27,450,308...27,465,822

G

histidine decarboxylase

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of HDC mRNA

NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341

G

hedgehog acyltransferase-like

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of HHATL mRNA

NCBI chr 8:130,324,510...130,331,580
Ensembl chr 8:121,447,002...121,454,001

G

hexokinase domain containing 1

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of HKDC1 mRNA

NCBI chr20:30,335,322...30,373,792
Ensembl chr20:30,335,628...30,373,867

G

hydroxysteroid 11-beta dehydrogenase 1

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of HSD11B1 mRNA

NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687

G

integrin-binding sialoprotein

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in increased expression of IBSP mRNA

NCBI chr14:5,439,825...5,452,570
Ensembl chr14:5,439,829...5,452,693

G

interferon gamma

multiple interactions
increases expression

EXP
ISO

[Iodine co-treated with Dibutyl Phthalate] results in increased expression of IFNG protein; pyrazolanthrone inhibits the reaction [[Iodine co-treated with Dibutyl Phthalate] results in increased expression of IFNG protein]
Iodine results in increased expression of IFNG protein

PMID:29385629 PMID:37598415

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375

G

insulin-like growth factor binding protein 6

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of IGFBP6 mRNA

NCBI chr 7:133,276,309...133,280,944
Ensembl chr 7:133,276,234...133,280,966

G

interleukin 17A

multiple interactions
increases expression

EXP
ISO

[Iodine co-treated with Dibutyl Phthalate] results in increased expression of IL17A protein; pyrazolanthrone inhibits the reaction [[Iodine co-treated with Dibutyl Phthalate] results in increased expression of IL17A protein]
Iodine results in increased expression of IL17A protein

PMID:29385629 PMID:37598415

NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:23,144,402...23,147,889

G

interleukin 1 beta

multiple interactions

EXP

[Iodine co-treated with Dibutyl Phthalate] results in increased expression of IL1B protein

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 2

increases expression

EXP
ISO

Iodine results in increased expression of IL2 protein

PMID:19035182 PMID:37598415

NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 6

multiple interactions

EXP

[Iodine co-treated with Dibutyl Phthalate] results in increased expression of IL6 protein; pyrazolanthrone inhibits the reaction [[Iodine co-treated with Dibutyl Phthalate] results in increased expression of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178

G

interphotoreceptor matrix proteoglycan 1

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of IMPG1 mRNA

NCBI chr 8:81,243,624...81,389,722
Ensembl chr 8:81,243,624...81,389,722

G

iroquois homeobox 5

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of IRX5 mRNA

NCBI chr19:14,639,052...14,643,911
Ensembl chr19:14,624,225...14,642,318

G

interferon stimulated exonuclease gene 20

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of ISG20 mRNA

NCBI chr 1:132,829,303...132,837,027
Ensembl chr 1:132,815,123...132,837,027

G

inter-alpha trypsin inhibitor, heavy chain 3

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of ITIH3 mRNA

NCBI chr16:6,101,922...6,117,154
Ensembl chr16:6,101,930...6,116,924

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions

EXP

Iodine results in increased expression of JUN mRNA; Iodine results in increased expression of JUN protein
[Iodine co-treated with Dibutyl Phthalate] results in increased phosphorylation of and results in increased activity of JUN protein; [Selenium co-treated with Iodine] results in increased expression of JUN mRNA; [Selenium co-treated with Iodine] results in increased expression of JUN protein

PMID:12475444 PMID:12666833 PMID:29385629

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656

G

potassium voltage-gated channel subfamily E regulatory subunit 2

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of KCNE2 mRNA

NCBI chr11:31,517,176...31,530,026
Ensembl chr11:31,295,614...31,530,043

G

potassium inwardly-rectifying channel, subfamily J, member 10

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of KCNJ10 mRNA

NCBI chr13:84,802,026...84,835,383
Ensembl chr13:84,802,009...84,835,461

G

potassium inwardly-rectifying channel, subfamily J, member 13

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of KCNJ13 mRNA

NCBI chr 9:88,063,003...88,071,112
Ensembl chr 9:88,063,003...88,071,112

G

Klotho

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of KL mRNA

NCBI chr12:5,326,003...5,367,016
Ensembl chr12:490,399...530,080

G

kelch-like family member 1

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of KLHL1 mRNA

NCBI chr15:72,698,191...73,142,726
Ensembl chr15:72,699,094...73,142,594

G

keratin 18

multiple interactions

EXP

[Iodine deficiency co-treated with sodium perchlorate] results in decreased expression of KRT18 protein

NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
Ensembl chr10:133,157,475...133,161,166

G

lipopolysaccharide binding protein

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of LBP mRNA

NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586

G

LEM domain containing 1

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in increased expression of LEMD1 mRNA

NCBI chr13:43,631,705...43,697,765
Ensembl chr13:43,665,926...43,697,948

G

leptin

multiple interactions

EXP

[Iodine deficiency co-treated with sodium perchlorate] results in increased secretion of LEP protein

NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262

G

leucine rich repeat containing G protein coupled receptor 5

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in increased expression of LGR5 mRNA

NCBI chr 7:51,087,059...51,221,882
Ensembl chr 7:51,088,239...51,222,446

G

luteinizing hormone subunit beta

multiple interactions

EXP

[Iodine deficiency co-treated with sodium perchlorate] results in decreased secretion of LHB protein

NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

lysyl oxidase-like 1

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of LOXL1 mRNA

NCBI chr 8:58,691,763...58,716,365
Ensembl chr 8:58,692,593...58,716,356

G

LDL receptor related protein 1

multiple interactions

ISO

[Iodine deficiency co-treated with Propylthiouracil] results in decreased expression of LRP1 protein; Triiodothyronine inhibits the reaction [[Iodine deficiency co-treated with Propylthiouracil] results in decreased expression of LRP1 protein]

NCBI chr 7:65,265,639...65,346,196
Ensembl chr 7:63,380,356...63,460,910

G

LDL receptor related protein 2

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of LRP2 mRNA

NCBI chr 3:74,597,148...74,754,535
Ensembl chr 3:54,189,308...54,346,708

G

lymphocyte antigen 6 family member A

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of LY6A mRNA

NCBI chr 7:107,177,191...107,189,436
Ensembl chr 7:107,183,469...107,189,981

G

microtubule-associated protein 1B

decreases expression

EXP

Iodine deficiency results in decreased expression of MAP1B protein

NCBI chr 2:32,551,423...32,644,471
Ensembl chr 2:30,817,261...30,910,317

G

myelin basic protein

decreases expression
multiple interactions

ISO

Iodine results in decreased expression of MBP mRNA
Selenium inhibits the reaction [Iodine results in decreased expression of MBP mRNA]

NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404

G

melanocortin 3 receptor

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in increased expression of MC3R mRNA

NCBI chr 3:161,016,347...161,017,444
Ensembl chr 3:161,016,347...161,017,444

G

microfibril associated protein 4

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of MFAP4 mRNA

NCBI chr10:46,167,158...46,170,176
Ensembl chr10:46,167,217...46,170,155

G

membrane frizzled-related protein

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of MFRP mRNA

NCBI chr 8:44,445,636...44,450,859
Ensembl chr 8:44,445,697...44,450,859

G

matrix Gla protein

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of MGP mRNA

NCBI chr 4:169,766,290...169,769,612
Ensembl chr 4:169,766,279...169,769,667

G

Mirlet7b host gene

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in increased expression of LNCPPARA mRNA

G

MISP family member 3

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of MISP3 mRNA

NCBI chr19:24,139,998...24,142,006
Ensembl chr19:24,140,033...24,142,631

G

msh homeobox 1

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of MSX1 mRNA

NCBI chr14:77,185,802...77,189,735
Ensembl chr14:72,961,148...72,964,966

G

myosin binding protein C3

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of MYBPC3 mRNA

NCBI chr 3:77,095,165...77,113,406
Ensembl chr 3:77,095,252...77,113,405

G

myosin heavy chain 3

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of MYH3 mRNA

NCBI chr10:52,269,185...52,293,000
Ensembl chr10:51,770,177...51,793,992

G

myosin, light chain 4

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of MYL4 mRNA

NCBI chr10:89,949,733...89,985,308
Ensembl chr10:89,449,443...89,485,363

G

myotilin

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in increased expression of MYOT mRNA

NCBI chr18:36,705,244...36,724,849
Ensembl chr18:36,705,314...36,724,841

G

neuron-derived neurotrophic factor

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of NDNF mRNA

NCBI chr 4:94,944,392...94,981,871
Ensembl chr 4:94,944,360...94,981,873

G

neuronal differentiation 1

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of NEUROD1 mRNA

NCBI chr 3:64,359,554...64,363,526
Ensembl chr 3:64,359,395...64,363,649

G

neuronal differentiation 2

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of NEUROD2 mRNA

NCBI chr10:83,323,801...83,327,986
Ensembl chr10:83,324,442...83,327,986

G

neuronal differentiation 6

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of NEUROD6 mRNA

NCBI chr 4:84,846,659...84,849,905
Ensembl chr 4:84,846,231...84,849,999

G

neurogenin 2

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of NEUROG2 mRNA

NCBI chr 2:218,767,205...218,769,772
Ensembl chr 2:216,093,363...216,094,154

G

NFKB inhibitor alpha

multiple interactions

EXP

Iodine deficiency results in increased expression of and results in decreased phosphorylation of NFKBIA protein

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941

G

natriuretic peptide C

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of NPPC mRNA

NCBI chr 9:87,320,051...87,324,251
Ensembl chr 9:87,320,051...87,324,251

G

neuronal pentraxin 1

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of NPTX1 mRNA

NCBI chr10:104,811,107...104,820,358
Ensembl chr10:104,811,403...104,820,367

G

nuclear receptor subfamily 1, group I, member 3

multiple interactions

ISO

NR1I3 protein affects the reaction [[Iodine deficiency co-treated with Propylthiouracil] results in decreased expression of CYP3A11 mRNA]

NCBI chr13:86,165,327...86,170,362
Ensembl chr13:83,632,899...83,637,906

G

nuclear receptor subfamily 4, group A, member 3

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of NR4A3 mRNA

NCBI chr 5:67,157,141...67,198,287
Ensembl chr 5:62,361,822...62,402,733

G

neurogranin

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of NRGN mRNA

NCBI chr 8:37,255,462...37,263,659
Ensembl chr 8:37,256,930...37,257,516

G

nucleoporin 62 C-terminal like

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of NUP62CL mRNA

NCBI chr X:103,668,458...103,724,957
Ensembl chr X:103,668,455...103,724,081

G

neurexophilin 3

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of NXPH3 mRNA

NCBI chr10:80,456,283...80,459,949
Ensembl chr10:80,455,429...80,462,415

G

occludin

multiple interactions

ISO

[gamma-Linolenic Acid co-treated with Iodine co-treated with Selenium] results in increased expression of and results in increased localization of OCLN protein; [gamma-Linolenic Acid co-treated with Iodine] results in increased expression of and results in increased localization of OCLN protein; [Selenium co-treated with Iodine] results in increased expression of and results in increased localization of OCLN protein; Iodine results in increased expression of and results in increased localization of OCLN protein

NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:31,657,220...31,764,150

G

opticin

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in increased expression of OPTC mRNA

NCBI chr13:45,353,954...45,368,254
Ensembl chr13:45,355,148...45,365,237

G

otogelin-like

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in increased expression of OTOGL mRNA

NCBI chr 7:43,065,800...43,211,400
Ensembl chr 7:43,067,644...43,223,592

G

peptidyl arginine deiminase 6

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of PADI6 mRNA

NCBI chr 5:153,021,855...153,037,443
Ensembl chr 5:153,021,965...153,037,414

G

progestin and adipoQ receptor family member 5

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of PAQR5 mRNA

NCBI chr 8:62,431,867...62,513,688
Ensembl chr 8:62,431,867...62,513,688

G

progestin and adipoQ receptor family member 6

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of PAQR6 mRNA

NCBI chr 2:173,832,241...173,838,443
Ensembl chr 2:173,833,880...173,838,456

G

protocadherin beta 1

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in increased expression of PCDHB1 mRNA

NCBI chr18:28,913,835...28,916,746
Ensembl chr18:28,913,989...28,916,445

G

programmed cell death 1

increases expression
multiple interactions

ISO

Iodine results in increased expression of PDCD1 mRNA; Iodine results in increased expression of PDCD1 protein
CD274 protein affects the reaction [Iodine results in increased expression of PDCD1 mRNA]; CD274 protein affects the reaction [Iodine results in increased expression of PDCD1 protein]

NCBI chr 9:101,866,124...101,879,278
Ensembl chr 9:94,418,791...94,431,937

G

programmed cell death 1 ligand 2

multiple interactions
increases expression

ISO

CD274 protein affects the reaction [Iodine results in increased expression of PDCD1LG2 mRNA]

NCBI chr 1:227,158,941...227,223,938
Ensembl chr 1:227,158,941...227,223,938

G

phospholipase A2, group V

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of PLA2G5 mRNA

NCBI chr 5:156,324,628...156,393,065
Ensembl chr 5:151,041,340...151,062,658

G

phosphatidylinositol-specific phospholipase C, X domain containing 3

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in increased expression of PLCXD3 mRNA

NCBI chr 2:53,567,022...53,746,384
Ensembl chr 2:53,567,022...53,746,384

G

paraoxonase 1

multiple interactions

EXP

[[Iodine deficiency co-treated with sodium perchlorate] affects the susceptibility to hexabromocyclododecane] which results in increased expression of PON1 protein; [Iodine deficiency co-treated with sodium perchlorate] results in decreased expression of PON1 protein

NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:33,294,722...33,321,360

G

paraoxonase 2

multiple interactions

EXP

[[Iodine deficiency co-treated with sodium perchlorate] affects the susceptibility to hexabromocyclododecane] which results in increased expression of PON2 protein

NCBI chr 4:33,389,702...33,425,186
Ensembl chr 4:33,389,714...33,425,248

G

PR/SET domain 8

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of PRDM8 mRNA

NCBI chr14:11,403,202...11,424,059
Ensembl chr14:11,404,407...11,410,993

G

prickle planar cell polarity protein 4

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in increased expression of PRICKLE4 mRNA

NCBI chr 9:13,297,494...13,305,635
Ensembl chr 9:13,297,758...13,305,630

G

prokineticin receptor 2

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in increased expression of PROKR2 mRNA

NCBI chr 3:140,077,629...140,092,327
Ensembl chr 3:119,627,601...119,635,718

G

proline rich 29

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of PRR29 mRNA

NCBI chr10:91,804,291...91,810,213
Ensembl chr10:91,305,723...91,310,439

G

proline rich 32

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of PRR32 mRNA

NCBI chr X:123,978,010...123,979,928
Ensembl chr X:123,977,985...123,979,942

G

serine protease 12

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of PRSS12 mRNA

NCBI chr 2:211,624,134...211,684,126
Ensembl chr 2:211,624,134...211,684,126

G

protein tyrosine phosphatase, receptor type, Q

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in increased expression of PTPRQ mRNA

NCBI chr 7:42,834,455...43,016,807
Ensembl chr 7:42,837,109...43,016,917

G

RASD family, member 2

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of RASD2 mRNA

NCBI chr19:13,594,291...13,605,016
Ensembl chr19:13,594,291...13,605,016

G

RAS-like, family 10, member A

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of RASL10A mRNA

NCBI chr14:79,955,093...79,956,471
Ensembl chr14:79,954,398...79,956,468

G

retinol binding protein 2

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of RBP2 mRNA

NCBI chr 8:99,079,293...99,104,489
Ensembl chr 8:99,079,104...99,104,473

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

EXP

Iodine deficiency results in decreased expression of and results in decreased phosphorylation of RELA protein

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484

G

roundabout guidance receptor 3

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of ROBO3 mRNA

NCBI chr 8:37,133,542...37,151,674
Ensembl chr 8:37,133,916...37,151,315

G

RP1, axonemal microtubule associated

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of RP1 mRNA

NCBI chr 5:15,121,104...15,582,363
Ensembl chr 5:15,121,133...15,579,363

G

R-spondin 2

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of RSPO2 mRNA

NCBI chr 7:74,096,378...74,239,398
Ensembl chr 7:74,103,090...74,238,933

G

reticulon 4 receptor-like 2

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of RTN4RL2 mRNA

NCBI chr 3:69,954,557...69,971,108
Ensembl chr 3:69,955,169...69,971,488

G

relaxin family peptide receptor 3

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in increased expression of RXFP3 mRNA

NCBI chr 2:61,730,376...61,731,806
Ensembl chr 2:60,003,256...60,004,686

G

S100 calcium binding protein A8

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of S100A8 mRNA

NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643

G

S100 calcium binding protein A9

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of S100A9 mRNA

NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230

G

SATB homeobox 2

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of SATB2 mRNA

NCBI chr 9:58,348,027...58,534,256
Ensembl chr 9:58,350,246...58,530,707

G

scavenger receptor class A, member 5

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of SCARA5 mRNA

NCBI chr15:39,880,017...39,985,007
Ensembl chr15:39,880,035...39,983,373

G

stearoyl-CoA desaturase

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of SCD1 mRNA

NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:243,269,747...243,282,562

G

sodium voltage-gated channel alpha subunit 9

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in increased expression of SCN9A mRNA

NCBI chr 3:51,145,148...51,293,342
Ensembl chr 3:51,145,146...51,293,516

G

SEBOX homeobox

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of SEBOX mRNA

NCBI chr10:63,399,215...63,400,086
Ensembl chr10:63,399,165...63,400,606

G

SEC14-like lipid binding 4

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of SEC14L4 mRNA

NCBI chr14:78,912,750...78,928,799
Ensembl chr14:78,912,750...78,956,099

G

semaphorin 3C

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of SEMA3C mRNA

NCBI chr 4:18,538,452...18,702,453
Ensembl chr 4:17,583,212...17,746,534

G

semaphorin 7A (John Milton Hagen blood group)

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of SEMA7A mRNA

NCBI chr 8:58,348,448...58,370,536
Ensembl chr 8:58,348,448...58,370,536

G

serpin family A member 7

multiple interactions

EXP

[Iodine co-treated with Dibutyl Phthalate] results in increased expression of SERPINA7 protein; pyrazolanthrone inhibits the reaction [[Iodine co-treated with Dibutyl Phthalate] results in increased expression of SERPINA7 protein]

NCBI chr X:102,663,242...102,722,319
Ensembl chr X:102,663,405...102,669,040

G

secreted frizzled-related protein 2

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in increased expression of SFRP2 mRNA

NCBI chr 2:171,387,536...171,395,081
Ensembl chr 2:169,089,517...169,097,063

G

secreted frizzled-related protein 5

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of SFRP5 mRNA

NCBI chr 1:241,006,762...241,011,224
Ensembl chr 1:241,006,762...241,011,224

G

sphingosine-1-phosphate phosphatase 2

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of SGPP2 mRNA

NCBI chr 9:87,211,155...87,331,787
Ensembl chr 9:79,763,284...79,880,457

G

SIX homeobox 2

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of SIX2 mRNA

NCBI chr 6:8,974,859...8,981,345
Ensembl chr 6:8,967,157...8,981,193

G

solute carrier family 13 member 4

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of SLC13A4 mRNA

NCBI chr 4:63,943,369...63,988,852
Ensembl chr 4:63,943,395...63,988,857

G

solute carrier family 17 member 7

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of SLC17A7 mRNA

NCBI chr 1:104,786,172...104,798,049
Ensembl chr 1:95,649,745...95,661,588

G

solute carrier family 22 member 3

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of SLC22A3 mRNA

NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612

G

solute carrier family 22 member 6

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of SLC22A6 mRNA

NCBI chr 1:214,951,493...214,960,317
Ensembl chr 1:205,522,729...205,531,173

G

solute carrier family 26, member 10

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of SLC26A10 mRNA

NCBI chr 7:62,995,165...63,005,099
Ensembl chr 7:62,995,381...63,004,087

G

solute carrier family 26 member 3

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of SLC26A3 mRNA

NCBI chr 6:48,023,892...48,064,829
Ensembl chr 6:48,023,892...48,064,772

G

solute carrier family 26 member 4

increases expression
multiple interactions

EXP

Iodine results in increased expression of SLC26A4 mRNA
Methylnitrosourea promotes the reaction [Iodine results in increased expression of SLC26A4 mRNA]

NCBI chr 6:53,835,102...53,873,968
Ensembl chr 6:48,107,588...48,145,703

G

solute carrier family 27 member 6

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in increased expression of SLC27A6 mRNA

NCBI chr18:52,040,241...52,099,622
Ensembl chr18:52,041,074...52,099,414

G

solute carrier family 47 member 1

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of SLC47A1 mRNA

NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637

G

solute carrier family 4 member 5

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of SLC4A5 mRNA

NCBI chr 4:115,710,101...115,810,330
Ensembl chr 4:115,725,592...115,810,323

G

solute carrier family 5 member 5

multiple interactions
affects transport
increases uptake

ISO
EXP

2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]; 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]; [[Butyrates co-treated with decitabine] results in increased expression of SLC5A5 mRNA] which results in increased uptake of Iodine; captax inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]; cypermethrin inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]; decamethrin inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]; Dibutyl Phthalate inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]; Indomethacin inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]; mancozeb inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]; polymarcine inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]; potassium perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]; sodium perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]; sodium thiocyanate inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]; triclocarban inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]
SLC5A5 protein affects the transport of Iodine

PMID:12602914 PMID:17332617 PMID:17408651 PMID:17967635 PMID:27979590

NCBI chr16:18,580,705...18,590,692
Ensembl chr16:18,546,709...18,556,697

G

sushi, nidogen and EGF-like domains 1

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of SNED1 mRNA

NCBI chr 9:93,774,087...93,834,003
Ensembl chr 9:93,774,119...93,830,694

G

sclerostin domain containing 1

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of SOSTDC1 mRNA

NCBI chr 6:58,778,623...58,782,797
Ensembl chr 6:53,051,354...53,055,579

G

sosondowah ankyrin repeat domain family member B

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of SOWAHB mRNA

NCBI chr14:15,029,203...15,033,038
Ensembl chr14:15,029,395...15,031,698

G

SPO11 initiator of meiotic double strand breaks

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of SPO11 mRNA

NCBI chr 3:161,755,299...161,770,930
Ensembl chr 3:161,757,519...161,770,925

G

serine palmitoyltransferase, long chain base subunit 3

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of SPTLC3 mRNA

NCBI chr 3:126,847,878...126,978,010
Ensembl chr 3:126,847,878...126,978,010

G

sarcalumenin

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of SRL mRNA

NCBI chr10:11,033,976...11,078,103
Ensembl chr10:11,034,035...11,078,101

G

SH3 and cysteine rich domain

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in increased expression of STAC mRNA

NCBI chr 8:111,530,800...111,653,228
Ensembl chr 8:111,530,800...111,654,008

G

stomatin like 3

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of STOML3 mRNA

NCBI chr 2:137,572,691...137,582,402
Ensembl chr 2:137,572,691...137,590,681

G

stereocilin

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in increased expression of STRC mRNA

NCBI chr 3:128,785,817...128,811,773
Ensembl chr 3:108,335,747...108,354,134

G

serine/threonine/tyrosine interacting like 2

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in increased expression of DUSP27 mRNA

NCBI chr13:78,349,361...78,378,480
Ensembl chr13:78,349,365...78,378,458

G

T-box brain transcription factor 1

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of TBR1 mRNA

NCBI chr 3:66,758,805...66,769,626
Ensembl chr 3:46,351,213...46,361,041

G

tektin 3

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of TEKT3 mRNA

NCBI chr10:47,729,635...47,763,589
Ensembl chr10:47,729,635...47,763,588

G

transferrin

multiple interactions

ISO

[ferric pyrophosphate co-treated with Iodine] results in increased expression of TF protein

NCBI chr 8:112,668,667...112,695,376
Ensembl chr 8:103,767,995...103,816,511

G

transferrin receptor

multiple interactions

ISO

[ferric pyrophosphate co-treated with Iodine] results in increased expression of TFRC protein

NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257

G

thyroglobulin

increases expression

ISO

Iodine results in increased expression of TG protein

NCBI chr 7:98,418,293...98,603,210
Ensembl chr 7:98,418,293...98,603,210

G

thrombospondin 1

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of THBS1 mRNA

NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440

G

thyroid hormone receptor alpha

increases expression
multiple interactions

ISO

Iodine results in increased expression of THRA mRNA
Selenium inhibits the reaction [Iodine results in increased expression of THRA mRNA]

NCBI chr10:84,198,141...84,225,659
Ensembl chr10:83,700,755...83,729,936

G

thyroid hormone receptor beta

increases expression
multiple interactions

ISO

Iodine results in increased expression of THRB mRNA
Selenium inhibits the reaction [Iodine results in increased expression of THRB mRNA]

NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916

G

tight junction protein 1

multiple interactions

ISO

[gamma-Linolenic Acid co-treated with Iodine co-treated with Selenium] results in increased expression of and results in increased localization of TJP1 protein; Iodine results in increased expression of and results in increased localization of TJP1 protein

NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:118,849,838...119,094,432

G

toll-like receptor 1

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in increased expression of TLR1 mRNA

NCBI chr14:43,384,127...43,396,765
Ensembl chr14:43,384,932...43,397,125

G

toll-like receptor 5

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in increased expression of TLR5 mRNA

NCBI chr13:94,634,778...94,658,992
Ensembl chr13:94,634,801...94,657,738

G

transmembrane protein 252

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of TMEM252 mRNA

NCBI chr 1:222,316,982...222,321,946
Ensembl chr 1:222,316,795...222,321,943

G

transmembrane protein 72

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of TMEM72 mRNA

NCBI chr 4:149,946,296...149,973,550
Ensembl chr 4:149,948,257...149,973,550

G

transmembrane protein 82

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in increased expression of TMEM82 mRNA

NCBI chr 5:153,927,486...153,931,942
Ensembl chr 5:153,927,471...153,936,979

G

tumor necrosis factor

multiple interactions
increases expression

ISO

Iodine inhibits the reaction [Mustard Gas results in increased expression of TNF protein]
Iodine results in increased expression of TNF protein

PMID:16001271 PMID:37598415

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

G

troponin T1, slow skeletal type

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of TNNT1 mRNA

NCBI chr 1:69,306,362...69,316,721
Ensembl chr 1:69,306,362...69,316,721

G

tenascin XB

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in increased expression of TNXB mRNA

G

tumor protein p63

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of TRP63 mRNA

NCBI chr11:88,343,647...88,554,543
Ensembl chr11:74,838,859...75,049,398

G

TraB domain containing 2B

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of TRABD2B mRNA

NCBI chr 5:127,941,198...128,158,946
Ensembl chr 5:127,941,114...128,143,747

G

TNF receptor-associated factor 1

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of TRAF1 mRNA

NCBI chr 3:18,222,024...18,242,163
Ensembl chr 3:18,222,054...18,241,807

G

Traf3 interacting protein 2

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of TRAF3IP2 mRNA

NCBI chr20:44,565,992...44,609,240
Ensembl chr20:43,011,450...43,054,667

G

thyroid stimulating hormone subunit beta

multiple interactions
affects abundance
increases secretion

ISO
EXP

efavirenz promotes the reaction [TSHB protein affects the abundance of Iodine]; Nevirapine promotes the reaction [TSHB protein affects the abundance of Iodine]; sodium perchlorate inhibits the reaction [efavirenz promotes the reaction [TSHB protein affects the abundance of Iodine]]; sodium perchlorate inhibits the reaction [Nevirapine promotes the reaction [TSHB protein affects the abundance of Iodine]]
Iodine deficiency results in increased secretion of TSHB protein
[Iodine deficiency co-treated with sodium perchlorate] results in increased secretion of TSHB protein

PMID:16030158 PMID:20882593 PMID:30090431

NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559

G

transthyretin

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of TTR mRNA

NCBI chr18:12,216,684...12,225,972
Ensembl chr18:11,943,789...11,951,008

G

tubulin, alpha 8

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of TUBA8 mRNA

NCBI chr 4:154,440,045...154,456,918
Ensembl chr 4:154,440,074...154,456,917

G

upper zone of growth plate and cartilage matrix associated

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of UCMA mRNA

NCBI chr17:73,293,977...73,303,709
Ensembl chr17:73,293,978...73,303,611

G

unc-5 family C-terminal like

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of UNC5CL mRNA

NCBI chr 9:12,528,109...12,543,382
Ensembl chr 9:12,528,246...12,542,233

G

USH1 protein network component harmonin

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of USH1C mRNA

NCBI chr 1:96,695,303...96,743,671
Ensembl chr 1:96,695,307...96,743,671

G

USH1 protein network component sans

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of USH1G mRNA

NCBI chr10:100,559,721...100,563,590
Ensembl chr10:100,557,629...100,563,590

G

vasoactive intestinal peptide

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of VIP mRNA

NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216

G

Wnt family member 9A

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of WNT9A mRNA

NCBI chr10:44,593,691...44,620,682
Ensembl chr10:44,094,140...44,121,133

G

YY2 transcription factor

multiple interactions

ISO

[Propylthiouracil co-treated with Iodine deficiency] results in increased expression of YY2 mRNA

NCBI chr X:37,438,425...37,442,047
Ensembl chr X:37,410,811...37,464,430

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	20856
role	20816
biological role	20814
physiological role	20813
food component	20813
nutrient	20801
diiodine	241
Path 2
Term	Annotations
CHEBI ontology	20856
chemical entity	20854
molecular entity	20853
elemental molecular entity	17494
elemental halogen	11035
elemental iodine	346
diatomic iodine	241
diiodine	241

paths to the root