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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:diiodine
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Accession:CHEBI:17606 term browser browse the term
Definition:Molecule comprising two covalently bonded iodine atoms with overall zero charge..
Synonyms:related_synonym: Formula=I2;   I2;   InChI=1S/I2/c1-2;   InChIKey=PNDPGZBMCMUPRI-UHFFFAOYSA-N;   Iodine;   Jod;   SMILES=II;   molecular iodine
 alt_id: CHEBI:14461;   CHEBI:5947
 xref: Beilstein:3587194;   CAS:7553-56-2;   Drug_Central:4446;   Gmelin:1160;   KEGG:C01382;   KEGG:D00108
 xref_mesh: MESH:D007455
 xref: PMID:15206581;   PMID:19672279;   PMID:20045605;   PMID:24504625


show annotations for term's descendants           Sort by:
diiodine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 multiple interactions EXP [Iodine deficiency co-treated with sodium perchlorate] results in decreased expression of ALDH1L1 protein CTD PMID:30090431 NCBI chr 4:123,059,989...123,106,471
Ensembl chr 4:123,060,008...123,106,465 		JBrowse link
G Aldh5a1 aldehyde dehydrogenase 5 family, member A1 multiple interactions EXP [Iodine deficiency co-treated with sodium perchlorate] results in decreased expression of ALDH5A1 protein CTD PMID:30090431 NCBI chr17:40,132,339...40,158,677
Ensembl chr17:40,130,883...40,158,677 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [Diatrizoate co-treated with Iodine] results in increased expression of BAX protein CTD PMID:17173243 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [Diatrizoate co-treated with Iodine] results in increased expression of BCL2 protein CTD PMID:17173243 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Diatrizoate co-treated with Iodine] results in increased activity of CASP3 protein CTD PMID:17173243 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cd86 CD86 molecule increases expression EXP Iodine results in increased expression of CD86 mRNA CTD PMID:19035182 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 decreases expression EXP Iodine deficiency results in decreased expression of CDK5R1 protein CTD PMID:22987596 NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456 		JBrowse link
G Clcn5 chloride voltage-gated channel 5 increases abundance
increases uptake		 ISO CLCN5 gene mutant form results in increased abundance of Iodine
CLCN5 gene mutant form results in increased uptake of Iodine		 CTD PMID:16306076 NCBI chr  X:15,185,353...15,339,977
Ensembl chr  X:15,185,451...15,334,264 		JBrowse link
G Cldn5 claudin 5 multiple interactions ISO [gamma-Linolenic Acid co-treated with Iodine co-treated with Selenium] results in increased expression of and results in increased localization of CLDN5 protein; [gamma-Linolenic Acid co-treated with Iodine] results in increased expression of and results in increased localization of CLDN5 protein; [Selenium co-treated with Iodine] results in increased expression of and results in increased localization of CLDN5 protein; Iodine results in increased expression of and results in increased localization of CLDN5 protein CTD PMID:16514648 NCBI chr11:82,212,822...82,214,248
Ensembl chr11:82,211,475...82,214,992 		JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO Iodine results in increased expression of COL1A1 mRNA CTD PMID:22083529 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Cth cystathionine gamma-lyase multiple interactions EXP [Iodine deficiency co-treated with sodium perchlorate] results in decreased expression of CTH protein CTD PMID:30090431 NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234 		JBrowse link
G Cyb5a cytochrome b5 type A multiple interactions EXP [[Iodine deficiency co-treated with sodium perchlorate] affects the susceptibility to hexabromocyclododecane] which results in decreased expression of CYB5A protein CTD PMID:30090431 NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535
Ensembl chr18:78,202,342...78,258,535 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions ISO [Iodine deficiency co-treated with Propylthiouracil] results in increased expression of CYP2B10 mRNA CTD PMID:22503787 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases activity
multiple interactions
increases expression
decreases expression		 ISO
EXP		 Iodine results in decreased activity of DIO1 protein
Methylnitrosourea inhibits the reaction [Iodine results in increased expression of DIO1 mRNA]
Selenium inhibits the reaction [Iodine results in decreased activity of DIO1 protein]; Selenium inhibits the reaction [Iodine results in decreased expression of DIO1 mRNA]		 CTD PMID:15922087 PMID:17044649 NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions		 EXP Iodine results in increased expression of FOS mRNA; Iodine results in increased expression of FOS protein
[Selenium co-treated with Iodine] results in increased expression of FOS mRNA; [Selenium co-treated with Iodine] results in increased expression of FOS protein		 CTD PMID:12475444 PMID:12666833 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Ftcd formimidoyltransferase cyclodeaminase multiple interactions EXP [[Iodine deficiency co-treated with sodium perchlorate] affects the susceptibility to hexabromocyclododecane] which results in decreased expression of FTCD protein CTD PMID:30090431 NCBI chr20:12,055,203...12,068,717
Ensembl chr20:12,055,208...12,068,735 		JBrowse link
G Gamt guanidinoacetate N-methyltransferase multiple interactions EXP [[Iodine deficiency co-treated with sodium perchlorate] affects the susceptibility to hexabromocyclododecane] which results in increased expression of GAMT protein CTD PMID:30090431 NCBI chr 7:9,448,590...9,451,778
Ensembl chr 7:9,448,628...9,451,778 		JBrowse link
G Ifng interferon gamma multiple interactions EXP [Iodine co-treated with Dibutyl Phthalate] results in increased expression of IFNG protein; pyrazolanthrone inhibits the reaction [[Iodine co-treated with Dibutyl Phthalate] results in increased expression of IFNG protein] CTD PMID:29385629 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il17a interleukin 17A multiple interactions EXP [Iodine co-treated with Dibutyl Phthalate] results in increased expression of IL17A protein; pyrazolanthrone inhibits the reaction [[Iodine co-treated with Dibutyl Phthalate] results in increased expression of IL17A protein] CTD PMID:29385629 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP [Iodine co-treated with Dibutyl Phthalate] results in increased expression of IL1B protein CTD PMID:29385629 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 increases expression EXP Iodine results in increased expression of IL2 protein CTD PMID:19035182 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP [Iodine co-treated with Dibutyl Phthalate] results in increased expression of IL6 protein; pyrazolanthrone inhibits the reaction [[Iodine co-treated with Dibutyl Phthalate] results in increased expression of IL6 protein] CTD PMID:29385629 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions		 EXP Iodine results in increased expression of JUN mRNA; Iodine results in increased expression of JUN protein
[Iodine co-treated with Dibutyl Phthalate] results in increased phosphorylation of and results in increased activity of JUN protein; [Selenium co-treated with Iodine] results in increased expression of JUN mRNA; [Selenium co-treated with Iodine] results in increased expression of JUN protein		 CTD PMID:12475444 PMID:12666833 PMID:29385629 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Krt18 keratin 18 multiple interactions EXP [Iodine deficiency co-treated with sodium perchlorate] results in decreased expression of KRT18 protein CTD PMID:30090431 NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166 		JBrowse link
G Lep leptin multiple interactions EXP [Iodine deficiency co-treated with sodium perchlorate] results in increased secretion of LEP protein CTD PMID:30090431 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP [Iodine deficiency co-treated with sodium perchlorate] results in decreased secretion of LHB protein CTD PMID:30090431 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Map1b microtubule-associated protein 1B decreases expression EXP Iodine deficiency results in decreased expression of MAP1B protein CTD PMID:27444543 NCBI chr 2:30,817,261...30,910,458
Ensembl chr 2:30,817,261...30,910,317 		JBrowse link
G Mbp myelin basic protein decreases expression
multiple interactions		 ISO Iodine results in decreased expression of MBP mRNA
Selenium inhibits the reaction [Iodine results in decreased expression of MBP mRNA]		 CTD PMID:16229266 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP Iodine deficiency results in increased expression of and results in decreased phosphorylation of NFKBIA protein CTD PMID:27444543 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO NR1I3 protein affects the reaction [[Iodine deficiency co-treated with Propylthiouracil] results in decreased expression of CYP3A11 mRNA] CTD PMID:22503787 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Ocln occludin multiple interactions ISO [gamma-Linolenic Acid co-treated with Iodine co-treated with Selenium] results in increased expression of and results in increased localization of OCLN protein; [gamma-Linolenic Acid co-treated with Iodine] results in increased expression of and results in increased localization of OCLN protein; [Selenium co-treated with Iodine] results in increased expression of and results in increased localization of OCLN protein; Iodine results in increased expression of and results in increased localization of OCLN protein CTD PMID:16514648 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150 		JBrowse link
G Pon1 paraoxonase 1 multiple interactions EXP [[Iodine deficiency co-treated with sodium perchlorate] affects the susceptibility to hexabromocyclododecane] which results in increased expression of PON1 protein; [Iodine deficiency co-treated with sodium perchlorate] results in decreased expression of PON1 protein CTD PMID:30090431 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Pon2 paraoxonase 2 multiple interactions EXP [[Iodine deficiency co-treated with sodium perchlorate] affects the susceptibility to hexabromocyclododecane] which results in increased expression of PON2 protein CTD PMID:30090431 NCBI chr 4:33,389,702...33,425,186
Ensembl chr 4:33,389,714...33,425,248 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Iodine deficiency results in decreased expression of and results in decreased phosphorylation of RELA protein CTD PMID:27444543 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Serpina7 serpin family A member 7 multiple interactions EXP [Iodine co-treated with Dibutyl Phthalate] results in increased expression of SERPINA7 protein; pyrazolanthrone inhibits the reaction [[Iodine co-treated with Dibutyl Phthalate] results in increased expression of SERPINA7 protein] CTD PMID:29385629 NCBI chr  X:102,663,242...102,722,319
Ensembl chr  X:102,663,405...102,669,040 		JBrowse link
G Slc26a4 solute carrier family 26 member 4 increases expression
multiple interactions		 EXP Iodine results in increased expression of SLC26A4 mRNA
Methylnitrosourea promotes the reaction [Iodine results in increased expression of SLC26A4 mRNA]		 CTD PMID:15922087 NCBI chr 6:48,107,575...48,153,762
Ensembl chr 6:48,107,588...48,145,703 		JBrowse link
G Slc5a5 solute carrier family 5 member 5 multiple interactions
increases uptake
affects transport		 ISO
EXP		 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]; 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]; [[Butyrates co-treated with decitabine] results in increased expression of SLC5A5 mRNA] which results in increased uptake of Iodine; captax inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]; cypermethrin inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]; decamethrin inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]; Dibutyl Phthalate inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]; Indomethacin inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]; mancozeb inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]; polymarcine inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]; potassium perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]; sodium perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]; sodium thiocyanate inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]; triclocarban inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]
SLC5A5 protein affects the transport of Iodine		 CTD PMID:12602914 PMID:17332617 PMID:17408651 PMID:17967635 PMID:27979590 NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697 		JBrowse link
G Tf transferrin multiple interactions ISO [ferric pyrophosphate co-treated with Iodine] results in increased expression of TF protein CTD PMID:16772442 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511 		JBrowse link
G Tfrc transferrin receptor multiple interactions ISO [ferric pyrophosphate co-treated with Iodine] results in increased expression of TFRC protein CTD PMID:16772442 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Thra thyroid hormone receptor alpha increases expression
multiple interactions		 ISO Iodine results in increased expression of THRA mRNA
Selenium inhibits the reaction [Iodine results in increased expression of THRA mRNA]		 CTD PMID:17555094 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936 		JBrowse link
G Thrb thyroid hormone receptor beta increases expression
multiple interactions		 ISO Iodine results in increased expression of THRB mRNA
Selenium inhibits the reaction [Iodine results in increased expression of THRB mRNA]		 CTD PMID:17555094 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO [gamma-Linolenic Acid co-treated with Iodine co-treated with Selenium] results in increased expression of and results in increased localization of TJP1 protein; Iodine results in increased expression of and results in increased localization of TJP1 protein CTD PMID:16514648 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Iodine inhibits the reaction [Mustard Gas results in increased expression of TNF protein] CTD PMID:16001271 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions
increases secretion
affects abundance		 ISO
EXP		 efavirenz promotes the reaction [TSHB protein affects the abundance of Iodine]; Nevirapine promotes the reaction [TSHB protein affects the abundance of Iodine]; sodium perchlorate inhibits the reaction [efavirenz promotes the reaction [TSHB protein affects the abundance of Iodine]]; sodium perchlorate inhibits the reaction [Nevirapine promotes the reaction [TSHB protein affects the abundance of Iodine]]
[Iodine deficiency co-treated with sodium perchlorate] results in increased secretion of TSHB protein
Iodine deficiency results in increased secretion of TSHB protein		 CTD PMID:16030158 PMID:20882593 PMID:30090431 NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19765
    role 19738
      biological role 19736
        physiological role 19734
          food component 19734
            nutrient 19730
              diiodine 44
Path 2
Term Annotations click to browse term
  CHEBI ontology 19765
    chemical entity 19763
      molecular entity 19763
        elemental molecular entity 16739
          elemental halogen 9356
            elemental iodine 136
              diatomic iodine 44
                diiodine 44
paths to the root