Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:phorbol 12,13-dibutanoate
go back to main search page
Accession:CHEBI:17598 term browser browse the term
Definition:A phorbol ester that has formula C28H40O8.
Synonyms:exact_synonym: (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-9aH-cyclopropa[3,4]benzo[1,2-e]azulene-9,9a-diyl dibutanoate
 related_synonym: Formula=C28H40O8;   InChI=1S/C28H40O8/c1-7-9-20(30)35-24-16(4)27(34)18(22-25(5,6)28(22,24)36-21(31)10-8-2)12-17(14-29)13-26(33)19(27)11-15(3)23(26)32/h11-12,16,18-19,22,24,29,33-34H,7-10,13-14H2,1-6H3/t16-,18+,19-,22-,24-,26-,27-,28-/m1/s1;   InChIKey=BQJRUJTZSGYBEZ-YVQNUNKESA-N;   PDBu;   SMILES=[H][C@@]12C=C(CO)C[C@]3(O)C(=O)C(C)=C[C@@]3([H])[C@@]1(O)[C@H](C)[C@@H](OC(=O)CCC)[C@]1(OC(=O)CCC)[C@@]2([H])C1(C)C;   phorbol 12,13-dibutyrate
 alt_id: CHEBI:14789;   CHEBI:26015;   CHEBI:8117;   CHEBI:8120
 xref: Beilstein:6551234;   CAS:37558-16-0;   KEGG:C03634
 xref_mesh: MESH:D015240


show annotations for term's descendants           Sort by:
 
phorbol 12,13-dibutanoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam10 ADAM metallopeptidase domain 10 increases expression ISO Phorbol 12,13-Dibutyrate results in increased expression of ADAM10 protein CTD PMID:19476501 NCBI chr 8:71,346,008...71,477,889
Ensembl chr 8:71,345,837...71,477,889
JBrowse link
G Adam9 ADAM metallopeptidase domain 9 increases expression ISO Phorbol 12,13-Dibutyrate results in increased expression of ADAM9 protein CTD PMID:19476501 NCBI chr16:67,022,538...67,101,647
Ensembl chr16:67,022,655...67,100,917
JBrowse link
G App amyloid beta precursor protein increases secretion
multiple interactions
ISO Phorbol 12,13-Dibutyrate results in increased secretion of APP protein modified form
Go 6976 inhibits the reaction [Phorbol 12,13-Dibutyrate results in increased secretion of APP protein modified form]
CTD PMID:19476501 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Bace1 beta-secretase 1 multiple interactions
affects localization
ISO Go 6976 inhibits the reaction [Phorbol 12,13-Dibutyrate affects the localization of BACE1 protein] CTD PMID:19476501 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876
JBrowse link
G Casp9 caspase 9 increases cleavage
multiple interactions
ISO Phorbol 12,13-Dibutyrate results in increased cleavage of CASP9 protein
rottlerin inhibits the reaction [Phorbol 12,13-Dibutyrate results in increased cleavage of CASP9 protein]
CTD PMID:12626342 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO Phorbol 12,13-Dibutyrate inhibits the reaction [alvocidib inhibits the reaction [romidepsin results in increased expression of CDKN1A protein]]
Phorbol 12,13-Dibutyrate results in increased expression of CDKN1A protein
CTD PMID:15014036 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Phorbol 12,13-Dibutyrate inhibits the reaction [Asbestos, Crocidolite results in increased expression of FOS mRNA]; Phorbol 12,13-Dibutyrate inhibits the reaction [Lead results in increased expression of FOS mRNA]; Phorbol 12,13-Dibutyrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOS mRNA] CTD PMID:9242432 PMID:10693946 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions EXP Phorbol 12,13-Dibutyrate inhibits the reaction [N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide results in increased expression of HTR2A mRNA] CTD PMID:22791651 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
JBrowse link
G Il12a interleukin 12A increases expression ISO Phorbol 12,13-Dibutyrate results in increased expression of IL12A mRNA CTD PMID:15516327 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
JBrowse link
G Il12b interleukin 12B increases expression ISO Phorbol 12,13-Dibutyrate results in increased expression of IL12B mRNA CTD PMID:15516327 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il23a interleukin 23 subunit alpha increases expression ISO Phorbol 12,13-Dibutyrate results in increased expression of IL23A mRNA CTD PMID:15516327 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Phorbol 12,13-Dibutyrate inhibits the reaction [Asbestos, Crocidolite results in increased expression of JUN mRNA]; Phorbol 12,13-Dibutyrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUN mRNA] CTD PMID:9242432 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Phorbol 12,13-Dibutyrate inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Phorbol 12,13-Dibutyrate promotes the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein] CTD PMID:16251475 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Phorbol 12,13-Dibutyrate inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Phorbol 12,13-Dibutyrate promotes the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein] CTD PMID:16251475 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases activity
multiple interactions
ISO Phorbol 12,13-Dibutyrate results in increased activity of MMP9 protein
Quercetin inhibits the reaction [Phorbol 12,13-Dibutyrate results in increased activity of MMP9 protein]
CTD PMID:14593496 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Myl9 myosin light chain 9 multiple interactions
increases phosphorylation
EXP 2-methyl-1-((4-methyl-5-isoquinolinyl)sulfonyl)homopiperazine inhibits the reaction [Phorbol 12,13-Dibutyrate results in increased phosphorylation of MYL9 protein] CTD PMID:18986333 NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333
JBrowse link
G Ppp1r12a protein phosphatase 1, regulatory subunit 12A increases phosphorylation EXP Phorbol 12,13-Dibutyrate results in increased phosphorylation of PPP1R12A protein CTD PMID:18986333 NCBI chr 7:43,482,808...43,593,689
Ensembl chr 7:43,482,803...43,593,425
JBrowse link
G Ppp1r14a protein phosphatase 1, regulatory (inhibitor) subunit 14A multiple interactions
increases phosphorylation
EXP 2-methyl-1-((4-methyl-5-isoquinolinyl)sulfonyl)homopiperazine inhibits the reaction [Phorbol 12,13-Dibutyrate results in increased phosphorylation of PPP1R14A protein]; Ro 31-8220 inhibits the reaction [Phorbol 12,13-Dibutyrate results in increased phosphorylation of PPP1R14A protein] CTD PMID:18986333 NCBI chr 1:84,583,127...84,590,743
Ensembl chr 1:84,586,627...84,590,671
JBrowse link
G Prkca protein kinase C, alpha decreases expression
multiple interactions
increases expression
ISO
EXP
Phorbol 12,13-Dibutyrate results in decreased expression of PRKCA protein
Phorbol 12,13-Dibutyrate results in decreased expression of and affects the localization of PRKCA protein
Phorbol 12,13-Dibutyrate results in increased expression of PRKCA protein
CTD PMID:9242432 PMID:12626342 PMID:17171646 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Prkcd protein kinase C, delta increases expression
affects localization
affects binding
ISO Phorbol 12,13-Dibutyrate results in increased expression of PRKCD protein
Phorbol 12,13-Dibutyrate affects the localization of PRKCD protein
Phorbol 12,13-Dibutyrate binds to PRKCD protein
CTD PMID:8106444 PMID:12057904 PMID:12626342 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352
JBrowse link
G Prkce protein kinase C, epsilon affects binding ISO Phorbol 12,13-Dibutyrate binds to PRKCE protein CTD PMID:8106444 NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719
JBrowse link
G Prkcz protein kinase C, zeta increases expression ISO Phorbol 12,13-Dibutyrate results in increased expression of PRKCZ protein CTD PMID:12626342 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367
JBrowse link
G Psen1 presenilin 1 multiple interactions
increases expression
ISO Go 6976 inhibits the reaction [Phorbol 12,13-Dibutyrate results in increased expression of PSEN1 protein]
Phorbol 12,13-Dibutyrate results in increased expression of PSEN1 protein; Phorbol 12,13-Dibutyrate results in increased expression of PSEN1 protein modified form
CTD PMID:19476501 NCBI chr 6:103,323,014...103,375,088
Ensembl chr 6:103,323,120...103,371,650
JBrowse link
G Rhoa ras homolog family member A increases expression
multiple interactions
EXP Phorbol 12,13-Dibutyrate results in increased expression of RHOA protein modified form
Ro 31-8220 inhibits the reaction [Phorbol 12,13-Dibutyrate results in increased expression of RHOA protein modified form]
CTD PMID:18986333 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Slc22a25 solute carrier family 22, member 25 affects localization
decreases activity
multiple interactions
ISO Phorbol 12,13-Dibutyrate affects the localization of SLC22A9 protein
Phorbol 12,13-Dibutyrate results in decreased activity of SLC22A9 protein
Staurosporine inhibits the reaction [Phorbol 12,13-Dibutyrate affects the localization of SLC22A9 protein]; Staurosporine inhibits the reaction [Phorbol 12,13-Dibutyrate results in decreased activity of SLC22A9 protein]
CTD PMID:17341544 NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP Phorbol 12,13-Dibutyrate promotes the reaction [Capsaicin results in increased secretion of TAC1 protein]; Pregabalin inhibits the reaction [Phorbol 12,13-Dibutyrate promotes the reaction [Capsaicin results in increased secretion of TAC1 protein]] CTD PMID:14499429 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP [alpha-Linolenic Acid co-treated with Phorbol 12,13-Dibutyrate] results in increased activity of TRPV1 protein; [Arachidonic Acid co-treated with Phorbol 12,13-Dibutyrate] results in increased activity of TRPV1 protein; [Docosahexaenoic Acids co-treated with Phorbol 12,13-Dibutyrate] results in increased activity of TRPV1 protein modified form; [Eicosapentaenoic Acid co-treated with Phorbol 12,13-Dibutyrate] results in increased activity of TRPV1 protein modified form; capsazepine inhibits the reaction [[Docosahexaenoic Acids co-treated with Phorbol 12,13-Dibutyrate] results in increased activity of TRPV1 protein modified form]; capsazepine inhibits the reaction [[Eicosapentaenoic Acid co-treated with Phorbol 12,13-Dibutyrate] results in increased activity of TRPV1 protein modified form]; Linolenic Acids promotes the reaction [[Docosahexaenoic Acids co-treated with Phorbol 12,13-Dibutyrate] results in increased activity of TRPV1 protein modified form] CTD PMID:17038422 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    chemical entity 19812
      group 19733
        inorganic group 19265
          oxo group 18667
            organic oxo compound 18667
              carbonyl compound 18667
                carboxylic ester 15889
                  phorbol ester 929
                    phorbol 12,13-dibutanoate 27
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      ketone 16924
                                        oxyketone 8656
                                          alpha-oxyketone 8656
                                            alpha-hydroxy ketone 8656
                                              tertiary alpha-hydroxy ketone 8374
                                                phorbol 929
                                                  phorbol ester 929
                                                    phorbol 12,13-dibutanoate 27
paths to the root