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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:gemcitabine
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Accession:CHEBI:175901 term browser browse the term
Definition:A 2'-deoxycytidine having geminal fluoro substituents in the 2'-position. An inhibitor of ribonucleotide reductase, gemcitabine is used in the treatment of various carcinomas, particularly non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer.
Synonyms:related_synonym: 2',2'-Difluorodeoxycytidine;   2'-Deoxy-2',2'-difluorocytidine;   4-amino-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;   Formula=C9H11F2N3O4;   InChI=1S/C9H11F2N3O4/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17)/t4-,6-,7-/m1/s1;   InChIKey=SDUQYLNIPVEERB-QPPQHZFASA-N;   SMILES=Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)C2(F)F)c(=O)n1;   gemcitabina;   gemcitabinum
 alt_id: CHEBI:42752;   CHEBI:5295
 xref: Beilstein:5382060;   CAS:95058-81-4;   DrugBank:DB00441;   Drug_Central:1283;   KEGG:C07650;   KEGG:D02368;   LINCS:LSM-5333
 xref_mesh: MESH:C056507
 xref: PDBeChem:GEO;   PMID:11034044;   PMID:11061612;   PMID:11088063;   PMID:11122828;   PMID:11132538;   PMID:11142482;   PMID:11221019;   PMID:11356111;   PMID:11374818;   PMID:11489002;   PMID:11504793;   PMID:11510027;   PMID:11585734;   PMID:11595724;   PMID:11807603;   PMID:11859947;   PMID:11901308;   PMID:12057041;   PMID:12057046;   PMID:12057157;   PMID:12115355;   PMID:12142097;   PMID:12520460;   PMID:12571808;   PMID:12722678;   PMID:12722691;   PMID:12743987;   PMID:12761494;   PMID:12798170;   PMID:12917815;   PMID:12954073;   PMID:14606642;   PMID:14653877;   PMID:14720338;   PMID:15131028;   PMID:15160243;   PMID:15221904;   PMID:15282439;   PMID:15297392;   PMID:15542781;   PMID:15637766;   PMID:15744590;   PMID:16001951;   PMID:16041610;   PMID:16080557;   PMID:16143373;   PMID:16149285;   PMID:16317298;   PMID:16500746;   PMID:16555971;   PMID:16584929;   PMID:16807461;   PMID:16807463;   PMID:16894289;   PMID:16905983;   PMID:17101674;   PMID:17296311;   PMID:17296587;   PMID:17347561;   PMID:17429628;   PMID:17460420;   PMID:17602464;   PMID:17639396;   PMID:17887663;   PMID:17939651;   PMID:17941128;   PMID:17987263;   PMID:18035967;   PMID:18050344;   PMID:18086345;   PMID:18166944;   PMID:18186604;   PMID:18257544;   PMID:18348652;   PMID:18773046;   PMID:18789834;   PMID:18819792;   PMID:18981552;   PMID:19034448;   PMID:19177022;   PMID:19399788;   PMID:19839926;   PMID:19879060;   PMID:22763439;   PMID:28594276;   PMID:28608357;   PMID:28912244;   Patent:EP1939198;   Patent:EP2108368;   Patent:EP2275135;   Patent:GB2136425;   Patent:US2009124797;   Patent:US2010111852;   Patent:US4808614;   Reaxys:5382060;   Wikipedia:Gemcitabine



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gemcitabine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin increases expression ISO gemcitabine results in increased expression of A2M protein CTD PMID:20531411 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
JBrowse link
G Acp3 acid phosphatase 3 decreases expression ISO gemcitabine results in decreased expression of ACP3 protein CTD PMID:20531411 NCBI chr 8:104,905,570...104,956,146
Ensembl chr 8:104,905,586...104,954,236
JBrowse link
G Adam17 ADAM metallopeptidase domain 17 multiple interactions ISO ADAM17 protein promotes the reaction [gemcitabine results in increased cleavage of AREG protein] CTD PMID:20726858 NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO gemcitabine results in increased expression of ADIPOQ protein CTD PMID:20531411 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Afp alpha-fetoprotein decreases expression ISO gemcitabine results in decreased expression of AFP protein CTD PMID:20531411 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
JBrowse link
G Agpat2 1-acylglycerol-3-phosphate O-acyltransferase 2 decreases expression ISO gemcitabine results in decreased expression of AGPAT2 mRNA CTD PMID:17039268 NCBI chr 3:9,416,842...9,428,567
Ensembl chr 3:9,416,843...9,428,371
JBrowse link
G Akt1 AKT serine/threonine kinase 1 affects response to substance
multiple interactions
ISO AKT1 protein affects the susceptibility to gemcitabine
[gemcitabine co-treated with licoricidin] results in decreased phosphorylation of AKT1 protein; [licoricidin co-treated with gemcitabine] results in decreased phosphorylation of AKT1 protein
CTD PMID:15867245 PMID:29782821 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases expression
multiple interactions
ISO gemcitabine results in decreased expression of ALDH1A1 protein
sulforaphane promotes the reaction [gemcitabine results in decreased expression of ALDH1A1 protein]
CTD PMID:20940707 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 increases expression ISO gemcitabine results in increased expression of ALDH1A3 mRNA CTD PMID:17039268 NCBI chr 1:119,982,272...120,017,416
Ensembl chr 1:119,982,277...120,017,436
JBrowse link
G Aldh6a1 aldehyde dehydrogenase 6 family, member A1 increases expression ISO gemcitabine results in increased expression of ALDH6A1 mRNA CTD PMID:17039268 NCBI chr 6:104,077,975...104,098,636
Ensembl chr 6:104,077,979...104,098,656
JBrowse link
G Anapc1 anaphase promoting complex subunit 1 increases expression ISO gemcitabine results in increased expression of ANAPC1 mRNA CTD PMID:17039268 NCBI chr 3:115,850,117...115,930,259
Ensembl chr 3:115,850,185...115,930,273
JBrowse link
G Ank3 ankyrin 3 increases expression ISO gemcitabine results in increased expression of ANK3 mRNA CTD PMID:17039268 NCBI chr20:18,602,267...19,225,831
Ensembl chr20:18,602,786...19,086,300
JBrowse link
G Ankrd1 ankyrin repeat domain 1 increases expression ISO gemcitabine results in increased expression of ANKRD1 mRNA CTD PMID:17039268 NCBI chr 1:233,815,851...233,834,891
Ensembl chr 1:233,815,851...233,834,919
JBrowse link
G Antxr1 ANTXR cell adhesion molecule 1 affects expression ISO gemcitabine affects the expression of ANTXR1 mRNA CTD PMID:17039268 NCBI chr 4:119,590,770...119,778,232
Ensembl chr 4:119,590,771...119,778,232
JBrowse link
G Apcs amyloid P component, serum decreases expression ISO gemcitabine results in decreased expression of APCS protein CTD PMID:20531411 NCBI chr13:85,373,338...85,374,134
Ensembl chr13:85,373,220...85,374,298
JBrowse link
G Apoh apolipoprotein H increases expression ISO gemcitabine results in increased expression of APOH protein CTD PMID:20531411 NCBI chr10:93,342,435...93,356,334
Ensembl chr10:93,310,977...93,356,329
JBrowse link
G Ar androgen receptor multiple interactions ISO gemcitabine binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Areg amphiregulin multiple interactions
increases expression
increases cleavage
decreases response to substance
ISO ADAM17 protein promotes the reaction [gemcitabine results in increased cleavage of AREG protein]
gemcitabine results in increased expression of AREG protein
AREG protein results in decreased susceptibility to gemcitabine
CTD PMID:20726858 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535
JBrowse link
G Arf1 ADP-ribosylation factor 1 decreases expression ISO gemcitabine results in decreased expression of ARF1 mRNA CTD PMID:17039268 NCBI chr10:43,997,983...44,014,543
Ensembl chr10:43,997,986...44,014,434
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator increases expression ISO gemcitabine results in increased expression of ARNT mRNA CTD PMID:20103597 NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO gemcitabine results in increased expression of ATF3 mRNA CTD PMID:17039268 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Axin2 axin 2 affects expression ISO gemcitabine affects the expression of AXIN2 mRNA CTD PMID:20103597 NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231
JBrowse link
G Axl Axl receptor tyrosine kinase multiple interactions ISO AXL protein promotes the reaction [Warfarin results in increased susceptibility to gemcitabine] CTD PMID:26206560 NCBI chr 1:81,265,656...81,296,278
Ensembl chr 1:81,265,088...81,296,265
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [alvocidib co-treated with gemcitabine] results in increased expression of BAX protein; [ICI 118551 co-treated with gemcitabine] results in increased expression of BAX protein; [Mastic Resin co-treated with gemcitabine] results in increased expression of BAX protein; [TNFSF10 co-treated with gemcitabine] affects the localization of BAX protein CTD PMID:15770523 PMID:17671697 PMID:20523344 PMID:21570961 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO gemcitabine results in decreased expression of BCL2 protein
[alvocidib co-treated with gemcitabine] results in decreased expression of BCL2 protein; [Aminophylline co-treated with gemcitabine] results in decreased expression of BCL2 protein; [ICI 118551 co-treated with gemcitabine] results in decreased expression of BCL2 protein; [Mastic Resin co-treated with gemcitabine] results in decreased expression of BCL2 protein; [Theophylline co-treated with gemcitabine] results in decreased expression of BCL2 protein; gemcitabine inhibits the reaction [Fluorouracil results in decreased expression of BCL2 mRNA]; gemcitabine inhibits the reaction [Fluorouracil results in decreased expression of BCL2 protein]; U 0126 inhibits the reaction [gemcitabine results in decreased expression of BCL2 protein]
[Curcumin co-treated with gemcitabine] results in decreased expression of BCL2 protein
CTD PMID:15476743 PMID:15645133 PMID:15770523 PMID:16929163 PMID:17440100 More... NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression
ISO gemcitabine inhibits the reaction [Fluorouracil affects the expression of BCL2L1 mRNA]; gemcitabine inhibits the reaction [Fluorouracil affects the expression of BCL2L1 protein]
[Curcumin co-treated with gemcitabine] results in decreased expression of BCL2L1 protein
gemcitabine results in decreased expression of BCL2L1 protein
CTD PMID:15476743 PMID:16929163 PMID:17440100 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bcl2l11 BCL2 like 11 increases expression ISO gemcitabine results in increased expression of BCL2L11 mRNA CTD PMID:17039268 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
JBrowse link
G Bcl6 BCL6, transcription repressor increases expression ISO gemcitabine results in increased expression of BCL6 mRNA CTD PMID:17039268 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389
JBrowse link
G Bdnf brain-derived neurotrophic factor decreases expression ISO gemcitabine results in decreased expression of BDNF protein CTD PMID:20531411 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Bid BH3 interacting domain death agonist increases cleavage ISO gemcitabine results in increased cleavage of BID protein CTD PMID:14750167 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 increases expression ISO gemcitabine results in increased expression of BIRC2 mRNA CTD PMID:17039268 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 affects expression
multiple interactions
ISO gemcitabine affects the expression of BIRC3 mRNA
[Curcumin co-treated with gemcitabine] results in decreased expression of BIRC3 protein
CTD PMID:17039268 PMID:17440100 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO gemcitabine inhibits the reaction [Fluorouracil results in decreased expression of BIRC5 mRNA]; gemcitabine inhibits the reaction [Fluorouracil results in decreased expression of BIRC5 protein]
[Curcumin co-treated with gemcitabine] results in decreased expression of BIRC5 protein
CTD PMID:16929163 PMID:17440100 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Bnip3l BCL2 interacting protein 3 like increases expression ISO gemcitabine results in increased expression of BNIP3L mRNA CTD PMID:17039268 NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase decreases expression ISO gemcitabine results in decreased expression of BRAF mRNA CTD PMID:20103597 NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463
JBrowse link
G Brca1 BRCA1, DNA repair associated increases expression
decreases response to substance
ISO gemcitabine results in increased expression of BRCA1 mRNA
BRCA1 results in decreased susceptibility to gemcitabine
CTD PMID:20103597 PMID:21771338 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
JBrowse link
G Casp3 caspase 3 increases activity
increases expression
multiple interactions
increases cleavage
ISO gemcitabine results in increased activity of CASP3 protein
gemcitabine results in increased expression of CASP3 protein modified form
[10-propargyl-10-deazaaminopterin co-treated with gemcitabine] results in increased activity of CASP3 protein; [Curcumin co-treated with gemcitabine] results in decreased expression of CASP3 protein
gemcitabine results in increased cleavage of CASP3 protein
[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with gemcitabine] affects the activity of CASP3 protein; [3-(4-methylphenylsulfonyl)-2-propenenitrile co-treated with gemcitabine] affects the activity of CASP3 protein; [alvocidib co-treated with gemcitabine] results in increased cleavage of CASP3 protein; [Calcitriol co-treated with gemcitabine] results in increased expression of CASP3 protein; [gemcitabine co-treated with TNFRSF10B] affects the activity of CASP3 protein; [vorinostat co-treated with gemcitabine] results in increased activity of CASP3 protein; gemcitabine results in increased expression of and results in increased activity of CASP3 protein; licoricidin promotes the reaction [gemcitabine results in increased activity of CASP3 protein]; licoricidin promotes the reaction [gemcitabine results in increased expression of and results in increased activity of CASP3 protein]; Quercetin promotes the reaction [gemcitabine results in increased activity of CASP3 protein]; SMG1 protein inhibits the reaction [gemcitabine results in increased activity of CASP3 protein]
CTD PMID:12479703 PMID:15476743 PMID:15726400 PMID:15770523 PMID:16153448 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp6 caspase 6 multiple interactions ISO [Calcitriol co-treated with gemcitabine] results in increased expression of CASP6 protein CTD PMID:20699664 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
JBrowse link
G Casp8 caspase 8 multiple interactions
increases cleavage
increases activity
ISO [Calcitriol co-treated with gemcitabine] results in increased expression of CASP8 protein; [gemcitabine co-treated with TNFRSF10B] affects the activity of CASP8 protein; [TNFSF10 co-treated with gemcitabine] results in increased activity of CASP8 protein; gemcitabine results in increased activity of and results in increased cleavage of CASP8 protein; SFN protein inhibits the reaction [gemcitabine results in increased activity of and results in increased cleavage of CASP8 protein]; YAP1 protein affects the reaction [gemcitabine results in increased activity of and results in increased cleavage of CASP8 protein]
gemcitabine results in increased cleavage of CASP8 protein
gemcitabine results in increased activity of CASP8 protein
CTD PMID:12479703 PMID:14750167 PMID:17159604 PMID:17671697 PMID:18089714 More... NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage
increases activity
ISO [Calcitriol co-treated with gemcitabine] results in increased expression of CASP9 protein; Quercetin promotes the reaction [gemcitabine results in increased activity of CASP9 protein]; SMG1 protein inhibits the reaction [gemcitabine results in increased activity of CASP9 protein]
[Curcumin co-treated with gemcitabine] results in decreased expression of CASP9 protein
gemcitabine results in increased cleavage of CASP9 protein
CTD PMID:12479703 PMID:15476743 PMID:15726400 PMID:17159604 PMID:17440100 More... NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO gemcitabine results in decreased expression of CCL2 protein CTD PMID:20531411 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression ISO gemcitabine results in increased expression of CCL20 mRNA CTD PMID:17039268 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO gemcitabine results in increased expression of CCL3 protein CTD PMID:20531411 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccnb1 cyclin B1 decreases expression
increases expression
ISO gemcitabine results in decreased expression of CCNB1 mRNA
gemcitabine results in increased expression of CCNB1 protein
CTD PMID:11504793 PMID:20103597 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO Celecoxib promotes the reaction [gemcitabine results in decreased expression of CCND1 protein]
gemcitabine results in decreased expression of CCND1 mRNA; gemcitabine results in decreased expression of CCND1 protein
[Curcumin co-treated with gemcitabine] results in decreased expression of CCND1 protein
CTD PMID:16060994 PMID:17039268 PMID:17440100 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccng2 cyclin G2 increases expression ISO gemcitabine results in increased expression of CCNG2 mRNA CTD PMID:17039268 NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830
JBrowse link
G Cd274 CD274 molecule multiple interactions ISO [Oleanolic Acid co-treated with gemcitabine] inhibits the reaction [IL1B protein results in increased expression of CD274 mRNA]; [Oleanolic Acid co-treated with gemcitabine] inhibits the reaction [IL1B protein results in increased expression of CD274 protein]; gemcitabine inhibits the reaction [IL1B protein results in increased expression of CD274 mRNA]; gemcitabine inhibits the reaction [IL1B protein results in increased expression of CD274 protein] CTD PMID:32894642 NCBI chr 1:227,116,627...227,137,379
Ensembl chr 1:227,116,649...227,134,450
JBrowse link
G Cd40 CD40 molecule decreases expression ISO gemcitabine results in decreased expression of CD40 mRNA; gemcitabine results in decreased expression of CD40 protein CTD PMID:17039268 PMID:20531411 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
JBrowse link
G Cd40lg CD40 ligand decreases expression ISO gemcitabine results in decreased expression of CD40LG protein CTD PMID:20531411 NCBI chr  X:135,127,119...135,138,302
Ensembl chr  X:135,126,969...135,138,306
JBrowse link
G Cda cytidine deaminase affects response to substance
multiple interactions
ISO CDA protein affects the susceptibility to gemcitabine
[crizotinib results in decreased expression of CDA protein] which results in increased susceptibility to gemcitabine; CDA protein affects the susceptibility to [gemcitabine co-treated with Mitomycin]; CDA protein affects the susceptibility to [gemcitabine co-treated with oxaliplatin]
CTD PMID:18728667 PMID:22973962 NCBI chr 5:150,556,615...150,583,231
Ensembl chr 5:150,556,615...150,583,231
JBrowse link
G Cdc25c cell division cycle 25C multiple interactions ISO [gemcitabine co-treated with ON 01910] results in decreased expression of CDC25C protein CTD PMID:20103597 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
JBrowse link
G Cdh1 cadherin 1 increases expression ISO gemcitabine results in increased expression of CDH1 mRNA CTD PMID:17039268 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO [alvocidib co-treated with gemcitabine] results in increased expression of CDKN1A protein; [gemcitabine results in decreased susceptibility to gemcitabine] which results in increased expression of CDKN1A protein; Nicotine inhibits the reaction [gemcitabine results in increased expression of CDKN1A protein]
gemcitabine results in increased expression of CDKN1A mRNA; gemcitabine results in increased expression of CDKN1A protein
CTD PMID:15476743 PMID:15770523 PMID:16601104 PMID:17039268 PMID:25189999 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases response to substance ISO CDKN1B results in decreased susceptibility to gemcitabine CTD PMID:21652059 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression ISO gemcitabine results in increased expression of CEBPB mRNA CTD PMID:17039268 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
JBrowse link
G Chrdl2 chordin-like 2 multiple interactions ISO [gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of CHRDL2 protein CTD PMID:24979617 NCBI chr 1:154,343,201...154,370,651
Ensembl chr 1:154,343,201...154,370,640
JBrowse link
G Ckb creatine kinase B decreases expression ISO gemcitabine results in decreased expression of CKB mRNA CTD PMID:17039268 NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315
JBrowse link
G Clic4 chloride intracellular channel 4 increases expression ISO gemcitabine results in increased expression of CLIC4 mRNA CTD PMID:17039268 NCBI chr 5:147,456,819...147,513,278
Ensembl chr 5:147,453,712...147,513,452
JBrowse link
G Clu clusterin affects response to substance
increases expression
ISO CLU protein affects the susceptibility to gemcitabine
gemcitabine results in increased expression of CLU protein
CTD PMID:19007378 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions
increases expression
ISO BAY 11-7085 inhibits the reaction [gemcitabine results in increased expression of CNR1 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [gemcitabine results in increased expression of CNR1 mRNA]; Dactinomycin inhibits the reaction [gemcitabine results in increased expression of CNR1 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [gemcitabine results in increased expression of CNR1 mRNA] CTD PMID:21525939 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
JBrowse link
G Cnr2 cannabinoid receptor 2 multiple interactions
increases expression
ISO BAY 11-7085 inhibits the reaction [gemcitabine results in increased expression of CNR2 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [gemcitabine results in increased expression of CNR2 mRNA]; Dactinomycin inhibits the reaction [gemcitabine results in increased expression of CNR2 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [gemcitabine results in increased expression of CNR2 mRNA] CTD PMID:21525939 NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548
JBrowse link
G Csf2 colony stimulating factor 2 decreases expression ISO gemcitabine results in decreased expression of CSF2 protein CTD PMID:20531411 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Csf3 colony stimulating factor 3 decreases expression ISO gemcitabine results in decreased expression of CSF3 protein CTD PMID:20531411 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603
JBrowse link
G Csrp2 cysteine and glycine-rich protein 2 increases expression ISO gemcitabine results in increased expression of CSRP2 mRNA CTD PMID:17039268 NCBI chr 7:46,349,109...46,367,743
Ensembl chr 7:46,348,686...46,367,745
JBrowse link
G Cthrc1 collagen triple helix repeat containing 1 increases expression ISO gemcitabine results in increased expression of CTHRC1 mRNA CTD PMID:17039268 NCBI chr 7:70,122,474...70,132,756
Ensembl chr 7:70,122,474...70,132,756
JBrowse link
G Ctnnb1 catenin beta 1 increases expression ISO gemcitabine results in increased expression of CTNNB1 mRNA CTD PMID:25605917 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression ISO gemcitabine results in increased expression of CXCL1 mRNA CTD PMID:17039268 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 multiple interactions ISO [gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of CXCL11 protein CTD PMID:24979617 NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO gemcitabine results in increased expression of CXCL2 mRNA CTD PMID:17039268 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO gemcitabine results in increased expression of CXCL1 mRNA CTD PMID:17039268 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 affects expression ISO gemcitabine affects the expression of CXCR4 mRNA CTD PMID:20103597 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 decreases expression ISO gemcitabine results in decreased expression of CYP24A1 mRNA CTD PMID:17039268 NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 affects expression ISO gemcitabine affects the expression of DDIT4 mRNA CTD PMID:17039268 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
JBrowse link
G Dhx9 DExH-box helicase 9 decreases expression ISO gemcitabine results in decreased expression of DHX9 mRNA CTD PMID:17039268 NCBI chr13:65,602,322...65,639,098
Ensembl chr13:65,602,323...65,639,069
JBrowse link
G Dlg2 discs large MAGUK scaffold protein 2 increases expression ISO gemcitabine results in increased expression of DLG2 mRNA CTD PMID:17039268 NCBI chr 1:144,451,653...146,503,949
Ensembl chr 1:144,451,472...146,499,475
JBrowse link
G Dnmt1 DNA methyltransferase 1 multiple interactions ISO [DNMT1 protein binds to SFN promoter] inhibits the reaction [gemcitabine results in decreased susceptibility to gemcitabine]; [gemcitabine results in decreased susceptibility to gemcitabine] inhibits the reaction [DNMT1 protein binds to SFN promoter]; [gemcitabine results in decreased susceptibility to gemcitabine] which results in increased expression of DNMT1 protein; [UHRF1 protein promotes the reaction [DNMT1 protein binds to SFN promoter]] inhibits the reaction [gemcitabine results in decreased susceptibility to gemcitabine]; DNMT1 protein inhibits the reaction [gemcitabine results in decreased susceptibility to gemcitabine] CTD PMID:25189999 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
JBrowse link
G Dnmt3b DNA methyltransferase 3 beta multiple interactions ISO [gemcitabine results in decreased susceptibility to gemcitabine] which results in increased expression of DNMT3B protein CTD PMID:25189999 NCBI chr 3:142,130,592...142,169,124
Ensembl chr 3:142,130,592...142,169,124
JBrowse link
G Dpyd dihydropyrimidine dehydrogenase multiple interactions ISO [TYMP protein co-treated with DPYD protein] affects the susceptibility to gemcitabine CTD PMID:18728667 NCBI chr 2:206,609,043...207,474,982
Ensembl chr 2:206,609,122...207,474,982
JBrowse link
G Dync1h1 dynein cytoplasmic 1 heavy chain 1 decreases expression ISO gemcitabine results in decreased expression of DYNC1H1 mRNA CTD PMID:17039268 NCBI chr 6:129,615,208...129,680,888
Ensembl chr 6:129,609,397...129,680,883
JBrowse link
G Edn1 endothelin 1 decreases expression ISO gemcitabine results in decreased expression of EDN1 protein CTD PMID:20531411 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Edn2 endothelin 2 decreases expression ISO gemcitabine results in decreased expression of EDN2 mRNA CTD PMID:17039268 NCBI chr 5:133,751,316...133,756,814
Ensembl chr 5:133,751,217...133,756,814
JBrowse link
G Egf epidermal growth factor multiple interactions
decreases expression
ISO 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]]; EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]; Erlotinib Hydrochloride inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]]; pyrazolanthrone inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]]; U 0126 inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]]
gemcitabine results in decreased expression of EGF protein
CTD PMID:20531411 PMID:21613822 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
increases phosphorylation
increases expression
decreases expression
increases degradation
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [gemcitabine results in increased phosphorylation of and results in increased degradation of EGFR protein]; EGFR gene mutant form results in increased susceptibility to [gemcitabine co-treated with Cisplatin co-treated with Erlotinib Hydrochloride]; Gefitinib inhibits the reaction [gemcitabine results in increased phosphorylation of and results in increased degradation of EGFR protein]; gemcitabine promotes the reaction [HER3 protein binds to EGFR protein]
gemcitabine results in increased phosphorylation of EGFR protein
gemcitabine results in increased expression of EGFR mRNA
gemcitabine results in decreased expression of EGFR mRNA; gemcitabine results in decreased expression of EGFR protein
gemcitabine results in increased degradation of EGFR protein
CTD PMID:17146438 PMID:20103597 PMID:20726858 PMID:21541241 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Egr1 early growth response 1 increases expression ISO gemcitabine results in increased expression of EGR1 mRNA CTD PMID:17039268 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO gemcitabine binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Etv1 ETS variant transcription factor 1 increases expression ISO gemcitabine results in increased expression of ETV1 mRNA CTD PMID:17039268 NCBI chr 6:55,590,149...55,681,784
Ensembl chr 6:55,590,234...55,681,775
JBrowse link
G Evi2b ecotropic viral integration site 2B decreases expression ISO gemcitabine results in decreased expression of EVI2B mRNA CTD PMID:17039268 NCBI chr10:64,472,693...64,474,311
Ensembl chr10:64,471,505...64,481,560
JBrowse link
G F7 coagulation factor VII decreases expression ISO gemcitabine results in decreased expression of F7 protein CTD PMID:20531411 NCBI chr16:76,489,779...76,500,636
Ensembl chr16:76,489,717...76,500,610
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO gemcitabine results in increased expression of FAS mRNA; gemcitabine results in increased expression of FAS protein CTD PMID:11138460 PMID:17159604 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fbxo25 F-box protein 25 increases expression ISO gemcitabine results in increased expression of FBXO25 mRNA CTD PMID:17039268 NCBI chr16:75,666,062...75,701,770
Ensembl chr16:75,667,904...75,701,696
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions
increases expression
ISO [gemcitabine co-treated with IFNA2 protein] results in increased expression of FGF2 protein
gemcitabine results in increased expression of FGF2 protein
CTD PMID:12738744 PMID:20531411 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Fgg fibrinogen gamma chain affects expression ISO gemcitabine affects the expression of FGG mRNA CTD PMID:17039268 NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322
JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit decreases expression ISO gemcitabine results in decreased expression of FOSL2 mRNA CTD PMID:17039268 NCBI chr 6:24,297,898...24,319,157
Ensembl chr 6:24,300,956...24,320,034
JBrowse link
G Fxyd3 FXYD domain-containing ion transport regulator 3 increases expression ISO gemcitabine results in increased expression of FXYD3 mRNA CTD PMID:17039268 NCBI chr 1:86,305,531...86,312,455 JBrowse link
G Gal3st1 galactose-3-O-sulfotransferase 1 decreases expression ISO gemcitabine results in decreased expression of GAL3ST1 mRNA CTD PMID:17039268 NCBI chr14:78,868,049...78,886,402
Ensembl chr14:78,870,793...78,886,388
JBrowse link
G Gas1 growth arrest-specific 1 decreases expression ISO gemcitabine results in decreased expression of GAS1 mRNA CTD PMID:17039268 NCBI chr17:4,482,014...4,485,155 JBrowse link
G Gask1b golgi associated kinase 1B decreases expression ISO gemcitabine results in decreased expression of GASK1B mRNA CTD PMID:17039268 NCBI chr 2:165,047,689...165,112,479
Ensembl chr 2:165,047,684...165,112,477
JBrowse link
G Gdf15 growth differentiation factor 15 multiple interactions ISO [gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of GDF15 protein CTD PMID:24979617 NCBI chr16:18,805,312...18,807,893
Ensembl chr16:18,805,239...18,808,055
JBrowse link
G Gipc1 GIPC PDZ domain containing family, member 1 affects response to substance ISO GIPC1 affects the susceptibility to gemcitabine CTD PMID:25469510 NCBI chr19:24,474,291...24,487,083
Ensembl chr19:24,453,123...24,486,997
JBrowse link
G Gli2 GLI family zinc finger 2 affects expression ISO gemcitabine affects the expression of GLI2 mRNA CTD PMID:20103597 NCBI chr13:29,946,809...30,163,901
Ensembl chr13:29,946,809...30,163,574
JBrowse link
G Glrx glutaredoxin increases expression ISO gemcitabine results in increased expression of GLRX mRNA CTD PMID:17039268 NCBI chr 2:5,341,873...5,351,686
Ensembl chr 2:5,341,885...5,351,680
JBrowse link
G Gpc3 glypican 3 increases expression ISO gemcitabine results in increased expression of GPC3 mRNA CTD PMID:17039268 NCBI chr  X:131,868,983...132,236,837
Ensembl chr  X:131,868,990...132,236,798
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation ISO gemcitabine results in increased phosphorylation of GSK3B protein CTD PMID:16570353 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gtf2a1 general transcription factor 2A subunit 1 affects expression ISO gemcitabine affects the expression of GTF2A1 mRNA CTD PMID:17039268 NCBI chr 6:110,488,891...110,521,059
Ensembl chr 6:110,488,931...110,521,511
JBrowse link
G H4c3 H4 clustered histone 3 decreases expression ISO gemcitabine results in decreased expression of H4C3 mRNA CTD PMID:17039268
G Hdac9 histone deacetylase 9 increases expression ISO gemcitabine results in increased expression of HDAC9 mRNA CTD PMID:17039268 NCBI chr 6:50,762,074...51,624,311
Ensembl chr 6:50,763,590...51,625,333
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha affects response to substance ISO HIF1A protein affects the susceptibility to gemcitabine CTD PMID:16628086 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hist2h4 histone cluster 2, H4 decreases expression ISO gemcitabine results in decreased expression of H4C2 mRNA CTD PMID:17039268 NCBI chr 2:183,831,601...183,831,996
Ensembl chr 2:183,825,994...183,832,048
JBrowse link
G Hoxb2 homeobox B2 increases expression ISO gemcitabine results in increased expression of HOXB2 mRNA CTD PMID:17039268 NCBI chr10:81,317,927...81,320,223
Ensembl chr10:81,318,026...81,320,192
JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like decreases expression ISO gemcitabine results in decreased expression of HSPA1L mRNA CTD PMID:17039268 NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO gemcitabine results in increased expression of HSPA5 mRNA CTD PMID:17039268 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases expression
ISO [Curcumin co-treated with gemcitabine] results in decreased expression of ICAM1 protein
gemcitabine results in decreased expression of ICAM1 protein
CTD PMID:17440100 PMID:20531411 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifng interferon gamma decreases expression ISO gemcitabine results in decreased expression of IFNG protein CTD PMID:20531411 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases expression ISO gemcitabine results in decreased expression of IGF1R mRNA CTD PMID:20103597 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 affects expression ISO gemcitabine affects the expression of IGFBP3 mRNA CTD PMID:20103597 NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083
JBrowse link
G Il10 interleukin 10 decreases expression ISO gemcitabine results in decreased expression of IL10 protein CTD PMID:20531411 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il13 interleukin 13 increases expression ISO gemcitabine results in increased expression of IL13 protein CTD PMID:20531411 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il15 interleukin 15 decreases expression ISO gemcitabine results in decreased expression of IL15 protein CTD PMID:20531411 NCBI chr19:25,640,013...25,706,818
Ensembl chr19:25,640,251...25,706,820
JBrowse link
G Il16 interleukin 16 increases expression ISO gemcitabine results in increased expression of IL16 protein CTD PMID:20531411 NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130
JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO gemcitabine results in decreased expression of IL1A protein CTD PMID:20531411 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta decreases expression
multiple interactions
ISO gemcitabine results in decreased expression of IL1B protein
[Oleanolic Acid co-treated with gemcitabine] inhibits the reaction [IL1B protein results in increased expression of CD274 mRNA]; [Oleanolic Acid co-treated with gemcitabine] inhibits the reaction [IL1B protein results in increased expression of CD274 protein]; gemcitabine inhibits the reaction [IL1B protein results in increased expression of CD274 mRNA]; gemcitabine inhibits the reaction [IL1B protein results in increased expression of CD274 protein]
CTD PMID:20531411 PMID:32894642 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il4 interleukin 4 decreases expression ISO gemcitabine results in decreased expression of IL4 protein CTD PMID:20531411 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 decreases expression
increases secretion
increases expression
ISO gemcitabine results in decreased expression of IL6 protein
gemcitabine results in increased secretion of IL6 protein
gemcitabine results in increased expression of IL6 mRNA
CTD PMID:17039268 PMID:20531411 PMID:28007550 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ilk integrin-linked kinase affects response to substance ISO ILK protein affects the susceptibility to gemcitabine CTD PMID:15867245 NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140
JBrowse link
G Ins2 insulin 2 increases expression ISO gemcitabine results in increased expression of INS protein CTD PMID:20531411 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Insig1 insulin induced gene 1 increases expression ISO gemcitabine results in increased expression of INSIG1 mRNA CTD PMID:17039268 NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952
JBrowse link
G Iqgap1 IQ motif containing GTPase activating protein 1 increases expression ISO gemcitabine results in increased expression of IQGAP1 mRNA CTD PMID:17039268 NCBI chr 1:134,679,581...134,769,776
Ensembl chr 1:134,679,586...134,769,755
JBrowse link
G Irak2 interleukin-1 receptor-associated kinase 2 increases expression ISO gemcitabine results in increased expression of IRAK2 mRNA CTD PMID:17039268 NCBI chr 4:146,786,004...146,842,615
Ensembl chr 4:146,786,100...146,842,602
JBrowse link
G Irf3 interferon regulatory factor 3 decreases expression ISO gemcitabine results in decreased expression of IRF3 mRNA CTD PMID:17039268 NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935
JBrowse link
G Itgav integrin subunit alpha V multiple interactions ISO [ITGB6 co-treated with ITGAV] affects the susceptibility to gemcitabine CTD PMID:20150628 NCBI chr 3:68,838,524...68,926,653
Ensembl chr 3:68,838,189...68,926,639
JBrowse link
G Itgb6 integrin subunit beta 6 multiple interactions ISO [ITGB6 co-treated with ITGAV] affects the susceptibility to gemcitabine CTD PMID:20150628 NCBI chr 3:45,046,295...45,170,532
Ensembl chr 3:45,048,044...45,121,671
JBrowse link
G Itsn2 intersectin 2 increases expression ISO gemcitabine results in increased expression of ITSN2 mRNA CTD PMID:17039268 NCBI chr 6:27,616,645...27,727,373
Ensembl chr 6:27,600,406...27,727,124
JBrowse link
G Jam3 junctional adhesion molecule 3 decreases expression ISO gemcitabine results in decreased expression of JAM3 mRNA CTD PMID:17039268 NCBI chr 8:25,508,461...25,569,306
Ensembl chr 8:25,507,057...25,569,355
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Copper co-treated with Disulfiram co-treated with gemcitabine] results in increased expression of and results in increased phosphorylation of JUN protein CTD PMID:23033007 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kctd12 potassium channel tetramerization domain containing 12 decreases expression ISO gemcitabine results in decreased expression of KCTD12 mRNA CTD PMID:17039268 NCBI chr15:79,800,077...79,806,064 JBrowse link
G Kitlg KIT ligand decreases expression
multiple interactions
ISO gemcitabine results in decreased expression of KITLG protein
[gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of KITLG protein
CTD PMID:20531411 PMID:24979617 NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214
JBrowse link
G Klf8 Kruppel-like factor 8 increases expression ISO gemcitabine results in increased expression of KLF8 mRNA CTD PMID:17039268 NCBI chr  X:17,950,045...18,132,980
Ensembl chr  X:17,958,843...18,133,182
JBrowse link
G Krt8 keratin 8 decreases expression ISO gemcitabine results in decreased expression of KRT8 mRNA CTD PMID:17039268 NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728
JBrowse link
G Larp4b La ribonucleoprotein 4B increases expression ISO gemcitabine results in increased expression of LARP4B mRNA CTD PMID:17039268 NCBI chr17:61,138,709...61,217,423
Ensembl chr17:61,138,709...61,187,960
JBrowse link
G Lep leptin decreases expression ISO gemcitabine results in decreased expression of LEP protein CTD PMID:20531411 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Lifr LIF receptor subunit alpha increases expression ISO gemcitabine results in increased expression of LIFR mRNA CTD PMID:17039268 NCBI chr 2:56,224,393...56,292,988
Ensembl chr 2:56,250,120...56,286,699
JBrowse link
G Lpar6 lysophosphatidic acid receptor 6 decreases expression ISO gemcitabine results in decreased expression of LPAR6 mRNA CTD PMID:17039268 NCBI chr15:48,416,548...48,418,357
Ensembl chr15:48,416,544...48,422,331
JBrowse link
G Lrrc28 leucine rich repeat containing 28 increases expression ISO gemcitabine results in increased expression of LRRC28 mRNA CTD PMID:17039268 NCBI chr 1:121,116,833...121,245,805
Ensembl chr 1:121,127,733...121,245,784
JBrowse link
G Lta lymphotoxin alpha increases expression ISO gemcitabine results in increased expression of LTA protein CTD PMID:20531411 NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859
JBrowse link
G Lyz2 lysozyme 2 decreases expression ISO gemcitabine results in decreased expression of LYZ mRNA CTD PMID:17039268 NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106
JBrowse link
G Maf MAF bZIP transcription factor increases expression ISO gemcitabine results in increased expression of MAF mRNA CTD PMID:17039268 NCBI chr19:43,353,867...43,713,162
Ensembl chr19:43,360,342...43,712,365
JBrowse link
G Magea10 MAGE family member A10 decreases expression ISO gemcitabine results in decreased expression of MAGEA10 mRNA CTD PMID:17039268 NCBI chr  X:150,212,001...150,218,253
Ensembl chr  X:150,213,245...150,214,213
JBrowse link
G Magi1 membrane associated guanylate kinase, WW and PDZ domain containing 1 increases expression ISO gemcitabine results in increased expression of MAGI1 mRNA CTD PMID:17039268 NCBI chr 4:126,205,667...126,811,354
Ensembl chr 4:126,206,816...126,811,691
JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 increases phosphorylation ISO gemcitabine results in increased phosphorylation of MAP2K3 protein CTD PMID:15003513 NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 increases phosphorylation ISO gemcitabine results in increased phosphorylation of MAP2K6 protein CTD PMID:15003513 NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO [Copper co-treated with Disulfiram co-treated with gemcitabine] results in increased phosphorylation of MAPK1 protein
gemcitabine results in increased phosphorylation of MAPK1 protein
CTD PMID:15476743 PMID:23033007 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO gemcitabine results in increased phosphorylation of MAPK3 protein
[Copper co-treated with Disulfiram co-treated with gemcitabine] results in increased phosphorylation of MAPK3 protein
CTD PMID:15476743 PMID:23033007 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate increases expression
increases phosphorylation
ISO gemcitabine results in increased expression of MARCKS mRNA
gemcitabine results in increased phosphorylation of MARCKS protein
CTD PMID:9523737 PMID:17039268 NCBI chr20:40,685,315...40,691,012
Ensembl chr20:40,685,315...40,691,012
JBrowse link
G Mars1 methionyl-tRNA synthetase 1 increases expression ISO gemcitabine results in increased expression of MARS1 mRNA CTD PMID:17039268 NCBI chr 7:63,121,142...63,138,550
Ensembl chr 7:63,121,142...63,138,495
JBrowse link
G Mdm2 MDM2 proto-oncogene decreases expression
increases expression
ISO gemcitabine results in decreased expression of MDM2 mRNA
gemcitabine results in increased expression of MDM2 mRNA
CTD PMID:17039268 PMID:20103597 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases expression ISO gemcitabine results in decreased expression of MGMT mRNA CTD PMID:17039268 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
JBrowse link
G Mir24-2 microRNA 24-2 multiple interactions ISO MIR24-2 mRNA affects the susceptibility to [betulinic acid co-treated with gemcitabine] CTD PMID:25841339 NCBI chr19:23,954,683...23,954,790
Ensembl chr19:23,954,683...23,954,790
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions ISO [Curcumin co-treated with gemcitabine] results in decreased expression of MKI67 protein CTD PMID:17440100 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mmp3 matrix metallopeptidase 3 decreases expression ISO gemcitabine results in decreased expression of MMP3 protein CTD PMID:20531411 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO [Curcumin co-treated with gemcitabine] results in decreased expression of MMP9 protein
[gemcitabine co-treated with IFNA2 protein] results in increased expression of MMP9 protein
CTD PMID:12738744 PMID:17440100 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpo myeloperoxidase increases expression ISO gemcitabine results in increased expression of MPO protein CTD PMID:20531411 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Msln mesothelin multiple interactions EXP gemcitabine results in decreased expression of and results in decreased secretion of MSLN protein alternative form CTD PMID:25347530 NCBI chr10:14,771,946...14,781,382
Ensembl chr10:14,771,961...14,777,643
JBrowse link
G Mt-co3 mitochondrially encoded cytochrome c oxidase III decreases response to substance
multiple interactions
ISO COX3 protein results in decreased susceptibility to gemcitabine
Sodium Azide inhibits the reaction [COX3 protein results in decreased susceptibility to gemcitabine]
CTD PMID:17428446 NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382
JBrowse link
G Mxi1 MAX interactor 1, dimerization protein increases expression ISO gemcitabine results in increased expression of MXI1 mRNA CTD PMID:17039268 NCBI chr 1:252,323,915...252,383,682
Ensembl chr 1:252,323,303...252,383,681
JBrowse link
G Myb MYB proto-oncogene, transcription factor increases expression ISO gemcitabine results in increased expression of MYB mRNA CTD PMID:17039268 NCBI chr 1:15,939,771...15,973,367
Ensembl chr 1:15,939,761...15,973,057
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor affects response to substance
multiple interactions
ISO MYC affects the susceptibility to gemcitabine
[Curcumin co-treated with gemcitabine] results in decreased expression of MYC protein
[Oligonucleotides binds to MYC gene] which results in increased susceptibility to gemcitabine
CTD PMID:17440100 PMID:23681918 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nanog Nanog homeobox decreases expression ISO gemcitabine results in decreased expression of NANOG mRNA CTD PMID:25605917 NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116
JBrowse link
G Ncbp1 nuclear cap binding protein subunit 1 increases expression ISO gemcitabine results in increased expression of NCBP1 mRNA CTD PMID:17039268 NCBI chr 5:60,416,023...60,449,004
Ensembl chr 5:60,415,982...60,449,089
JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 increases expression ISO gemcitabine results in increased expression of NEDD9 mRNA CTD PMID:17039268 NCBI chr17:23,289,793...23,468,026
Ensembl chr17:23,282,326...23,468,019
JBrowse link
G Neu1 neuraminidase 1 increases expression ISO gemcitabine results in increased expression of NEU1 mRNA CTD PMID:17039268 NCBI chr20:3,897,480...3,901,745
Ensembl chr20:3,897,480...3,901,745
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases response to substance ISO NFE2L2 protein results in decreased susceptibility to gemcitabine CTD PMID:21489257 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 affects expression ISO gemcitabine affects the expression of NFKB2 mRNA CTD PMID:17039268 NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO [Mastic Resin co-treated with gemcitabine] results in increased expression of NFKBIA protein CTD PMID:20523344 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nfkbie NFKB inhibitor epsilon affects expression ISO gemcitabine affects the expression of NFKBIE mRNA CTD PMID:17039268 NCBI chr 9:15,443,600...15,450,437
Ensembl chr 9:15,436,941...15,450,437
JBrowse link
G Nnmt nicotinamide N-methyltransferase increases expression ISO gemcitabine results in increased expression of NNMT mRNA CTD PMID:17039268 NCBI chr 8:48,928,663...48,947,734
Ensembl chr 8:48,933,598...48,946,655
JBrowse link
G Notch1 notch receptor 1 increases expression
multiple interactions
ISO gemcitabine results in increased expression of NOTCH1 protein
sulforaphane inhibits the reaction [gemcitabine results in increased expression of NOTCH1 protein]
CTD PMID:20940707 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
JBrowse link
G Npepps aminopeptidase puromycin sensitive decreases expression ISO gemcitabine results in decreased expression of NPEPPS mRNA CTD PMID:17039268 NCBI chr10:82,191,454...82,273,967
Ensembl chr10:82,191,456...82,273,967
JBrowse link
G Npm1 nucleophosmin 1 decreases response to substance ISO NPM1 protein results in decreased susceptibility to gemcitabine CTD PMID:24736981 NCBI chr10:17,741,512...17,751,626
Ensembl chr10:17,739,941...17,751,645
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 increases expression ISO gemcitabine results in increased expression of NR4A3 mRNA CTD PMID:17039268 NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733
JBrowse link
G Nrg1 neuregulin 1 increases expression ISO gemcitabine results in increased expression of NRG1 mRNA CTD PMID:17039268 NCBI chr16:59,250,658...60,303,024
Ensembl chr16:59,250,854...60,296,884
JBrowse link
G Nrp1 neuropilin 1 decreases response to substance ISO NRP1 protein results in decreased susceptibility to gemcitabine CTD PMID:15956974 NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator decreases expression
affects response to substance
ISO gemcitabine results in decreased expression of NUPR1 mRNA
NUPR1 affects the susceptibility to gemcitabine
CTD PMID:16397047 NCBI chr 1:181,213,292...181,215,327 JBrowse link
G Olr325 olfactory receptor 325 affects response to substance ISO OR4D6 gene SNP affects the susceptibility to gemcitabine CTD PMID:26378035 NCBI chr 1:209,039,073...209,040,017
Ensembl chr 1:209,037,992...209,045,985
JBrowse link
G Osm oncostatin M multiple interactions ISO [gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of OSM protein CTD PMID:24979617 NCBI chr14:79,103,638...79,108,500
Ensembl chr14:79,104,344...79,108,313
JBrowse link
G Pappa1 pappalysin 1 decreases expression ISO gemcitabine results in decreased expression of PAPPA protein CTD PMID:20531411 NCBI chr 5:78,497,660...78,735,873
Ensembl chr 5:78,498,300...78,730,666
JBrowse link
G Paqr8 progestin and adipoQ receptor family member 8 increases expression ISO gemcitabine results in increased expression of PAQR8 mRNA CTD PMID:17039268 NCBI chr 9:23,312,521...23,362,175
Ensembl chr 9:23,312,585...23,362,340
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO [alvocidib co-treated with gemcitabine] results in increased cleavage of PARP1 protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [gemcitabine results in increased cleavage of PARP1 protein]; SFN protein inhibits the reaction [gemcitabine results in increased cleavage of PARP1 protein]; YAP1 protein affects the reaction [gemcitabine results in increased cleavage of PARP1 protein] CTD PMID:15770523 PMID:17146438 PMID:26894857 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Parp2 poly (ADP-ribose) polymerase 2 decreases response to substance ISO PARP2 protein results in decreased susceptibility to gemcitabine CTD PMID:20798217 NCBI chr15:24,034,069...24,044,340
Ensembl chr15:24,034,106...24,044,338
JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 increases expression ISO gemcitabine results in increased expression of PCSK9 mRNA CTD PMID:17039268 NCBI chr 5:121,211,278...121,233,688
Ensembl chr 5:121,211,278...121,233,688
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 decreases response to substance ISO PDPK1 protein modified form results in decreased susceptibility to gemcitabine CTD PMID:16782806 NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623
JBrowse link
G Pdzk1ip1 PDZK1 interacting protein 1 increases expression ISO gemcitabine results in increased expression of PDZK1IP1 mRNA CTD PMID:17039268 NCBI chr 5:128,618,050...128,623,131
Ensembl chr 5:128,618,237...128,623,131
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 multiple interactions ISO gemcitabine promotes the reaction [Curcumin results in decreased expression of PECAM1 protein] CTD PMID:17440100 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
JBrowse link
G Pgr progesterone receptor multiple interactions ISO gemcitabine binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Pja2 praja ring finger ubiquitin ligase 2 increases expression ISO gemcitabine results in increased expression of PJA2 mRNA CTD PMID:17039268 NCBI chr 9:103,956,678...104,006,763
Ensembl chr 9:103,956,678...104,006,783
JBrowse link
G Plau plasminogen activator, urokinase increases expression ISO gemcitabine results in increased expression of PLAU mRNA CTD PMID:17039268 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
JBrowse link
G Plk1 polo-like kinase 1 decreases expression
affects response to substance
multiple interactions
ISO gemcitabine results in decreased expression of PLK1; gemcitabine results in decreased expression of PLK1 mRNA
PLK1 protein affects the susceptibility to gemcitabine
[gemcitabine results in decreased expression of PLK1] which results in increased susceptibility to gemcitabine; ON 01910 promotes the reaction [PLK1 protein affects the susceptibility to gemcitabine]
CTD PMID:20103597 NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha affects expression ISO gemcitabine affects the expression of PPARA mRNA CTD PMID:19427843 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta affects expression ISO gemcitabine affects the expression of PPARD mRNA CTD PMID:19427843 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects expression ISO gemcitabine affects the expression of PPARG mRNA CTD PMID:19427843 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppfia4 PTPRF interacting protein alpha 4 increases expression ISO gemcitabine results in increased expression of PPFIA4 mRNA CTD PMID:17039268 NCBI chr13:45,753,827...45,802,305
Ensembl chr13:45,753,827...45,802,261
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO gemcitabine results in increased expression of PPP1R15A mRNA CTD PMID:17039268 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
JBrowse link
G Psat1 phosphoserine aminotransferase 1 increases expression ISO gemcitabine results in increased expression of PSAT1 mRNA CTD PMID:17039268 NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682
JBrowse link
G Ptch1 patched 1 affects expression ISO gemcitabine affects the expression of PTCH1 mRNA CTD PMID:20103597 NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333
JBrowse link
G Pten phosphatase and tensin homolog affects expression ISO gemcitabine affects the expression of PTEN mRNA CTD PMID:17039268 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression ISO gemcitabine results in decreased expression of PTGS1 mRNA CTD PMID:17039268 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Curcumin co-treated with gemcitabine] results in decreased expression of PTGS2 protein CTD PMID:17440100 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases response to substance ISO PTK2 protein results in decreased susceptibility to gemcitabine CTD PMID:14623342 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 affects expression ISO gemcitabine affects the expression of PTPN11 mRNA CTD PMID:17039268 NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925
JBrowse link
G Rab8a RAB8A, member RAS oncogene family decreases expression ISO gemcitabine results in decreased expression of RAB8A mRNA CTD PMID:17039268 NCBI chr16:17,654,027...17,675,385
Ensembl chr16:17,654,034...17,675,678
JBrowse link
G Rbm17 RNA binding motif protein 17 decreases response to substance ISO RBM17 protein results in decreased susceptibility to gemcitabine CTD PMID:16061639 NCBI chr17:66,937,140...66,954,034
Ensembl chr17:66,937,140...66,954,014
JBrowse link
G Reg3b regenerating family member 3 beta decreases expression ISO gemcitabine results in decreased expression of REG3A mRNA CTD PMID:16570353 NCBI chr 4:110,861,775...110,865,015
Ensembl chr 4:110,861,775...110,865,015
JBrowse link
G Rel REL proto-oncogene, NF-kB subunit multiple interactions
decreases expression
ISO sulforaphane promotes the reaction [gemcitabine results in decreased expression of REL protein] CTD PMID:20940707 NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases phosphorylation
increases expression
ISO [gemcitabine co-treated with Doxorubicin co-treated with Paclitaxel] affects the localization of RELA protein; [gemcitabine co-treated with Doxorubicin co-treated with Paclitaxel] results in increased expression of RELA protein; licoricidin inhibits the reaction [gemcitabine results in increased phosphorylation of RELA protein]; Mastic Resin inhibits the reaction [gemcitabine results in increased expression of RELA protein]
[Curcumin co-treated with gemcitabine] results in decreased expression of RELA protein
CTD PMID:17039268 PMID:17440100 PMID:20523344 PMID:29782821 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rgs2 regulator of G-protein signaling 2 increases expression ISO gemcitabine results in increased expression of RGS2 mRNA CTD PMID:17039268 NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385
JBrowse link
G Rnf149 ring finger protein 149 increases expression ISO gemcitabine results in increased expression of RNF149 mRNA CTD PMID:17039268 NCBI chr 9:41,826,825...41,854,381
Ensembl chr 9:41,830,233...41,854,279
JBrowse link
G Rpl37 ribosomal protein L37 increases expression ISO gemcitabine results in increased expression of RPL37 mRNA CTD PMID:17039268 NCBI chr10:61,033,799...61,034,157
Ensembl chr10:61,033,797...61,034,168
JBrowse link
G Rragd Ras-related GTP binding D increases expression ISO gemcitabine results in increased expression of RRAGD mRNA CTD PMID:17039268 NCBI chr 5:47,373,902...47,409,369
Ensembl chr 5:47,373,463...47,409,356
JBrowse link
G Rrm1 ribonucleotide reductase catalytic subunit M1 multiple interactions
affects response to substance
ISO [gemcitabine results in decreased susceptibility to gemcitabine] which results in increased expression of RRM1 mRNA; [gemcitabine results in decreased susceptibility to gemcitabine] which results in increased expression of RRM1 protein
RRM1 protein affects the susceptibility to gemcitabine
CTD PMID:25189999 PMID:26894857 NCBI chr 1:156,823,960...156,848,262
Ensembl chr 1:156,823,960...156,848,261
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 multiple interactions
affects response to substance
decreases response to substance
ISO [gemcitabine results in decreased susceptibility to gemcitabine] which results in increased expression of RRM2 protein
RRM2 protein affects the susceptibility to gemcitabine
RRM2 protein results in decreased susceptibility to gemcitabine
CTD PMID:14661056 PMID:25189999 PMID:26894857 NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773
JBrowse link
G Rsl24d1 ribosomal L24 domain containing 1 increases expression ISO gemcitabine results in increased expression of RSL24D1 mRNA CTD PMID:17039268 NCBI chr 8:73,852,991...73,861,996
Ensembl chr 8:73,852,996...73,862,001
JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 increases expression ISO gemcitabine results in increased expression of SAT1 mRNA CTD PMID:17039268 NCBI chr  X:40,158,354...40,161,641
Ensembl chr  X:40,157,046...40,196,813
JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO gemcitabine results in increased expression of SCD mRNA CTD PMID:17039268 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Sfn stratifin multiple interactions
affects response to substance
decreases response to substance
increases methylation
ISO [DNMT1 protein binds to SFN promoter] inhibits the reaction [gemcitabine results in decreased susceptibility to gemcitabine]; [gemcitabine results in decreased susceptibility to gemcitabine] inhibits the reaction [DNMT1 protein binds to SFN promoter]; [gemcitabine results in decreased susceptibility to gemcitabine] which results in decreased methylation of SFN gene; [gemcitabine results in decreased susceptibility to gemcitabine] which results in increased expression of SFN mRNA; [gemcitabine results in decreased susceptibility to gemcitabine] which results in increased expression of SFN protein; [UHRF1 protein promotes the reaction [DNMT1 protein binds to SFN promoter]] inhibits the reaction [gemcitabine results in decreased susceptibility to gemcitabine]; SFN protein affects the reaction [YAP1 protein promotes the reaction [SFN protein results in decreased susceptibility to gemcitabine]]; SFN protein inhibits the reaction [gemcitabine results in increased activity of and results in increased cleavage of CASP8 protein]; SFN protein inhibits the reaction [gemcitabine results in increased cleavage of PARP1 protein]; SFN protein promotes the reaction [gemcitabine results in decreased susceptibility to gemcitabine]; YAP1 protein promotes the reaction [SFN protein results in decreased susceptibility to gemcitabine]
SFN protein affects the susceptibility to gemcitabine
gemcitabine results in increased methylation of SFN gene
CTD PMID:25189999 PMID:26894857 Ensembl chr 5:145,826,201...145,831,314 JBrowse link
G Shh sonic hedgehog signaling molecule decreases expression ISO gemcitabine results in decreased expression of SHH mRNA CTD PMID:20103597 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170
JBrowse link
G Slc25a29 solute carrier family 25 member 29 increases expression ISO gemcitabine results in increased expression of SLC25A29 mRNA CTD PMID:17039268 NCBI chr 6:127,742,027...127,752,915
Ensembl chr 6:127,742,033...127,752,940
JBrowse link
G Slc28a1 solute carrier family 28 member 1 multiple interactions ISO
EXP
gemcitabine inhibits the reaction [SLC28A1 protein results in increased transport of Uridine]
gemcitabine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]
CTD PMID:8713072 PMID:10772724 NCBI chr 1:135,079,375...135,122,791
Ensembl chr 1:135,081,385...135,122,464
JBrowse link
G Slc29a1 solute carrier family 29 member 1 increases response to substance
decreases response to substance
increases uptake
affects response to substance
multiple interactions
ISO SLC29A1 mRNA results in increased susceptibility to gemcitabine; SLC29A1 protein results in increased susceptibility to gemcitabine
SLC29A1 protein results in decreased susceptibility to gemcitabine
SLC29A1 protein results in increased uptake of gemcitabine
SLC29A1 protein affects the susceptibility to gemcitabine
4-nitrobenzylthioinosine inhibits the reaction [SLC29A1 protein results in increased uptake of gemcitabine]; [S 1 (combination) results in increased expression of SLC29A1 mRNA] which results in increased uptake of gemcitabine; Fluorouracil promotes the reaction [SLC29A1 protein results in increased uptake of gemcitabine]
CTD PMID:15501974 PMID:16868479 PMID:17695509 PMID:18383843 PMID:18452103 More... NCBI chr 9:15,399,661...15,414,203
Ensembl chr 9:15,399,612...15,414,203
JBrowse link
G Slc29a3 solute carrier family 29 member 3 affects transport ISO SLC29A3 protein affects the transport of gemcitabine CTD PMID:19164483 NCBI chr20:28,645,265...28,685,388
Ensembl chr20:28,647,391...28,685,388
JBrowse link
G Slc2a3 solute carrier family 2 member 3 increases expression ISO gemcitabine results in increased expression of SLC2A3 mRNA CTD PMID:17039268 NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472
JBrowse link
G Slc43a3 solute carrier family 43, member 3 decreases expression ISO gemcitabine results in decreased expression of SLC43A3 mRNA CTD PMID:17039268 NCBI chr 3:70,008,160...70,030,324
Ensembl chr 3:70,009,313...70,029,749
JBrowse link
G Slitrk2 SLIT and NTRK-like family, member 2 increases expression ISO gemcitabine results in increased expression of SLITRK2 mRNA CTD PMID:17039268 NCBI chr  X:145,246,448...145,259,983
Ensembl chr  X:145,246,460...145,271,220
JBrowse link
G Smg1 SMG1, nonsense mediated mRNA decay associated PI3K related kinase multiple interactions
decreases response to substance
ISO SMG1 protein inhibits the reaction [gemcitabine results in increased activity of CASP3 protein]; SMG1 protein inhibits the reaction [gemcitabine results in increased activity of CASP9 protein]
SMG1 protein results in decreased susceptibility to gemcitabine
CTD PMID:21418860 NCBI chr 1:172,441,892...172,543,667
Ensembl chr 1:172,444,936...172,543,698
JBrowse link
G Smo smoothened, frizzled class receptor increases expression ISO gemcitabine results in increased expression of SMO mRNA CTD PMID:25605917 NCBI chr 4:58,344,101...58,372,828
Ensembl chr 4:58,343,529...58,373,829
JBrowse link
G Sox2 SRY-box transcription factor 2 increases expression ISO gemcitabine results in increased expression of SOX2 mRNA CTD PMID:25605917 NCBI chr 2:117,536,929...117,539,338
Ensembl chr 2:117,536,929...117,539,338
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO gemcitabine results in increased expression of SPP1 mRNA CTD PMID:17039268 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions
decreases response to substance
affects response to substance
ISO [AG 1879 co-treated with SRC] results in increased susceptibility to gemcitabine
SRC protein modified form results in decreased susceptibility to gemcitabine; SRC protein results in decreased susceptibility to gemcitabine
SRC protein affects the susceptibility to gemcitabine
CTD PMID:15073106 PMID:15194078 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases activity ISO gemcitabine results in decreased activity of STAT3 protein CTD PMID:22348037 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Syncrip synaptotagmin binding, cytoplasmic RNA interacting protein decreases expression ISO gemcitabine results in decreased expression of SYNCRIP mRNA CTD PMID:17039268 NCBI chr 8:89,402,487...89,435,517
Ensembl chr 8:89,402,866...89,435,515
JBrowse link
G Szrd1 SUZ RNA binding domain containing 1 decreases expression ISO gemcitabine results in decreased expression of SZRD1 mRNA CTD PMID:17039268 NCBI chr 5:153,418,748...153,443,286
Ensembl chr 5:153,418,748...153,443,252
JBrowse link
G Tceal9 transcription elongation factor A like 9 increases expression ISO gemcitabine results in increased expression of TCEAL9 mRNA CTD PMID:17039268 NCBI chr  X:99,245,645...99,247,715
Ensembl chr  X:99,228,458...99,247,763
JBrowse link
G Tcof1 treacle ribosome biogenesis factor 1 decreases expression ISO gemcitabine results in decreased expression of TCOF1 mRNA CTD PMID:17039268 NCBI chr18:54,267,015...54,300,324
Ensembl chr18:54,267,026...54,300,324
JBrowse link
G Tert telomerase reverse transcriptase multiple interactions
decreases activity
ISO [Fluorouracil co-treated with gemcitabine] results in decreased activity of TERT protein
gemcitabine results in decreased activity of TERT protein
CTD PMID:16929163 NCBI chr 1:29,637,213...29,659,509
Ensembl chr 1:29,637,506...29,659,561
JBrowse link
G Tfap2a transcription factor AP-2 alpha multiple interactions
increases response to substance
ISO [TFAP2A protein co-treated with TP53 gene mutant form] results in decreased susceptibility to gemcitabine
TFAP2A protein results in increased susceptibility to gemcitabine
CTD PMID:21489314 NCBI chr17:24,028,716...24,047,507
Ensembl chr17:24,024,432...24,047,507
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases response to substance
multiple interactions
ISO TGFB1 results in decreased susceptibility to gemcitabine
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]]; EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]; Erlotinib Hydrochloride inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]]; pyrazolanthrone inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]]; U 0126 inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]]
CTD PMID:21613822 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression ISO gemcitabine results in increased expression of TGFB2 mRNA CTD PMID:17039268 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
JBrowse link
G Thpo thrombopoietin increases expression ISO gemcitabine results in increased expression of THPO protein CTD PMID:20531411 Ensembl chr11:80,182,820...80,188,167 JBrowse link
G Tnf tumor necrosis factor increases expression
affects expression
ISO gemcitabine results in increased expression of TNF protein
gemcitabine affects the expression of TNF mRNA
CTD PMID:17039268 PMID:20531411 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 increases expression ISO gemcitabine results in increased expression of TNFAIP3 mRNA CTD PMID:17039268 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases expression ISO gemcitabine results in increased expression of TNFRSF11B mRNA CTD PMID:17039268 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO [TNFSF10 co-treated with gemcitabine] affects the localization of BAX protein; [TNFSF10 co-treated with gemcitabine] results in increased activity of CASP8 protein CTD PMID:17671697 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Tnfsf8 TNF superfamily member 8 multiple interactions ISO [gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of TNFSF8 protein CTD PMID:24979617 NCBI chr 5:77,253,881...77,277,078
Ensembl chr 5:77,251,373...77,277,421
JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions
ISO gemcitabine results in increased expression of TP53 protein
[TFAP2A protein co-treated with TP53 gene mutant form] results in decreased susceptibility to gemcitabine; Nicotine inhibits the reaction [gemcitabine results in increased expression of TP53 protein]
CTD PMID:12082016 PMID:16601104 PMID:17671697 PMID:21489314 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 increases expression ISO gemcitabine results in increased expression of TP53BP1 mRNA CTD PMID:17039268 NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822
JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 increases expression ISO gemcitabine results in increased expression of TP53INP1 mRNA CTD PMID:16570353 PMID:17039268 NCBI chr 5:24,253,986...24,272,250
Ensembl chr 5:24,260,568...24,267,968
JBrowse link
G Traf1 TNF receptor-associated factor 1 affects expression ISO gemcitabine affects the expression of TRAF1 mRNA CTD PMID:17039268 NCBI chr 3:18,222,024...18,242,163
Ensembl chr 3:18,222,054...18,241,807
JBrowse link
G Tube1 tubulin, epsilon 1 increases expression ISO gemcitabine results in increased expression of TUBE1 mRNA CTD PMID:17039268 NCBI chr20:42,552,362...42,570,648
Ensembl chr20:42,552,437...42,570,314
JBrowse link
G Tymp thymidine phosphorylase affects response to substance
multiple interactions
ISO TYMP protein affects the susceptibility to gemcitabine
[TYMP protein co-treated with DPYD protein] affects the susceptibility to gemcitabine; TYMP protein affects the susceptibility to [gemcitabine co-treated with Mitomycin]
CTD PMID:18728667 NCBI chr 7:120,438,768...120,444,088
Ensembl chr 7:120,438,770...120,443,874
Ensembl chr 7:120,438,770...120,443,874
JBrowse link
G Tyrp1 tyrosinase-related protein 1 affects expression ISO gemcitabine affects the expression of TYRP1 mRNA CTD PMID:17039268 NCBI chr 5:95,280,982...95,299,516
Ensembl chr 5:95,280,982...95,299,516
JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C decreases expression ISO gemcitabine results in decreased expression of UBE2C mRNA CTD PMID:17039268 NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339
JBrowse link
G Uggt2 UDP-glucose glycoprotein glucosyltransferase 2 increases expression ISO gemcitabine results in increased expression of UGGT2 mRNA CTD PMID:17039268 NCBI chr15:96,074,557...96,239,365
Ensembl chr15:96,074,564...96,237,806
JBrowse link
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 multiple interactions ISO [gemcitabine results in decreased susceptibility to gemcitabine] which results in decreased expression of UHRF1 protein; [UHRF1 protein promotes the reaction [DNMT1 protein binds to SFN promoter]] inhibits the reaction [gemcitabine results in decreased susceptibility to gemcitabine]; UHRF1 protein inhibits the reaction [gemcitabine results in decreased susceptibility to gemcitabine] CTD PMID:25189999 NCBI chr 9:1,133,117...1,154,639
Ensembl chr 9:1,134,909...1,154,631
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression ISO gemcitabine results in decreased expression of VCAM1 protein CTD PMID:20531411 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
multiple interactions
ISO gemcitabine results in increased expression of VEGFA mRNA
[Curcumin co-treated with gemcitabine] results in decreased expression of VEGFA protein
CTD PMID:17039268 PMID:17440100 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vgf VGF nerve growth factor inducible decreases expression ISO gemcitabine results in decreased expression of VGF mRNA CTD PMID:17039268 NCBI chr12:19,637,313...19,645,123
Ensembl chr12:19,637,320...19,640,341
JBrowse link
G Vldlr very low density lipoprotein receptor increases expression ISO gemcitabine results in increased expression of VLDLR mRNA CTD PMID:17039268 NCBI chr 1:224,813,539...224,850,400
Ensembl chr 1:224,814,377...224,845,920
JBrowse link
G Vmp1 vacuole membrane protein 1 increases expression ISO gemcitabine results in increased expression of VMP1 CTD PMID:20299819 NCBI chr10:71,405,058...71,505,045
Ensembl chr10:71,405,452...71,505,007
JBrowse link
G Vwf von Willebrand factor decreases expression ISO gemcitabine results in decreased expression of VWF protein CTD PMID:20531411 NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539
JBrowse link
G Wnt5a Wnt family member 5A decreases expression ISO gemcitabine results in decreased expression of WNT5A mRNA CTD PMID:17039268 NCBI chr16:3,695,667...3,718,234
Ensembl chr16:3,697,032...3,718,234
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO gemcitabine promotes the reaction [1-(2,3-dichlorobenzoyl)-5-methoxy-2-methyl-(2-(mopholin-4-yl)ethyl)-1H-indole results in increased expression of XBP1 mRNA]; gemcitabine promotes the reaction [arachidonylcyclopropylamide results in increased expression of XBP1 mRNA]; gemcitabine promotes the reaction [rimonabant results in increased expression of XBP1 mRNA] CTD PMID:21525939 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
JBrowse link
G Xiap X-linked inhibitor of apoptosis affects response to substance ISO XIAP affects the susceptibility to gemcitabine CTD PMID:16628085 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link
G Yap1 Yes1 associated transcriptional regulator multiple interactions
affects response to substance
ISO SFN protein affects the reaction [YAP1 protein promotes the reaction [SFN protein results in decreased susceptibility to gemcitabine]]; YAP1 protein affects the reaction [gemcitabine results in increased activity of and results in increased cleavage of CASP8 protein]; YAP1 protein affects the reaction [gemcitabine results in increased cleavage of PARP1 protein]; YAP1 protein promotes the reaction [SFN protein results in decreased susceptibility to gemcitabine]
YAP1 protein affects the susceptibility to gemcitabine
CTD PMID:26894857 NCBI chr 8:5,095,705...5,166,808
Ensembl chr 8:5,095,722...5,167,010
JBrowse link
G Zfp110 zinc finger protein 110 increases expression ISO gemcitabine results in increased expression of ZNF274 mRNA CTD PMID:17039268 NCBI chr 1:73,445,303...73,461,112
Ensembl chr 1:73,445,336...73,461,086
JBrowse link
G Zfp449 zinc finger protein 449 increases expression ISO gemcitabine results in increased expression of ZNF449 mRNA CTD PMID:17039268 NCBI chr  X:134,120,820...134,140,921
Ensembl chr  X:134,122,636...134,140,924
JBrowse link
G Zfp521 zinc finger protein 521 decreases expression ISO gemcitabine results in decreased expression of ZNF521 mRNA CTD PMID:17039268 NCBI chr18:4,775,952...5,068,592
Ensembl chr18:4,787,295...5,068,458
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19795
    role 19746
      biological role 19746
        xenobiotic 18434
          gemcitabine 274
            gemcitabine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    p-block element atom 19693
                      carbon group element atom 19614
                        carbon atom 19604
                          organic molecular entity 19604
                            heteroorganic entity 19273
                              organochalcogen compound 19047
                                organooxygen compound 18993
                                  carbohydrates and carbohydrate derivatives 12344
                                    carbohydrate 12344
                                      carbohydrate derivative 11948
                                        glycosyl compound 10985
                                          N-glycosyl compound 5519
                                            nucleoside 5380
                                              deoxyribonucleoside 2739
                                                2'-deoxyribonucleoside 2221
                                                  pyrimidine 2'-deoxyribonucleoside 340
                                                    gemcitabine 274
                                                      gemcitabine hydrochloride 0
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