CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: linalool
Accession: CHEBI:17580
browse the term
Definition: A monoterpenoid that is octa-1,6-diene substituted by methyl groups at positions 3 and 7 and a hydroxy group at position 3. It has been isolated from plants like Ocimum canum.
Synonyms: related_synonym: 2,6-dimethylocta-2,7-dien-6-ol; 3,7-Dimethylocta-1,6-dien-3-ol; Formula=C10H18O; InChI=1S/C10H18O/c1-5-10(4,11)8-6-7-9(2)3/h5,7,11H,1,6,8H2,2-4H3; InChIKey=CDOSHBSSFJOMGT-UHFFFAOYSA-N; SMILES=CC(C)=CCCC(C)(O)C=C; beta-linalool; linalyl alcohol
alt_id: CHEBI:11712; CHEBI:1417; CHEBI:19917
xref: BPDB:2150; Beilstein:1362385; CAS:78-70-6; Gmelin:406448; HMDB:HMDB0036100; KEGG:C03985; KNApSAcK:C00003047; LIPID_MAPS_instance:LMPR0102010004
xref_mesh: MESH:C018584
xref: PMID:18695915; PMID:24570447; PMID:24758511; Reaxys:1362385; VSDB:2150; Wikipedia:Linalool
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Aco1
aconitase 1
increases expression
ISO
linalool results in increased expression of ACO1 mRNA
CTD
PMID:24752549
NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391
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Aco2
aconitase 2
increases expression
ISO
linalool results in increased expression of ACO2 mRNA
CTD
PMID:24752549
NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261
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Acox1
acyl-CoA oxidase 1
multiple interactions increases expression
ISO
PPARA protein promotes the reaction [linalool results in increased expression of ACOX1 protein] linalool results in increased expression of ACOX1 mRNA; linalool results in increased expression of ACOX1 protein PPARA gene mutant form inhibits the reaction [linalool results in increased expression of ACOX1 mRNA]; PPARA gene mutant form inhibits the reaction [linalool results in increased expression of ACOX1 protein]
CTD
PMID:24752549
NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232
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Acsl1
acyl-CoA synthetase long-chain family member 1
multiple interactions increases expression
ISO
PPARA gene mutant form inhibits the reaction [linalool results in increased expression of ACSL1 mRNA]; PPARA gene mutant form inhibits the reaction [linalool results in increased expression of ACSL1 protein] linalool results in increased expression of ACSL1 mRNA; linalool results in increased expression of ACSL1 protein PPARA protein promotes the reaction [linalool results in increased expression of ACSL1 protein]
CTD
PMID:24752549
NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541
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Akr1c2
aldo-keto reductase family 1, member C2
increases expression
ISO
linalool results in increased expression of AKR1C2 mRNA
CTD
PMID:20491607
NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
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Akt1
AKT serine/threonine kinase 1
increases expression
ISO
linalool results in increased expression of AKT1 mRNA
CTD
PMID:19922762
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Alas2
5'-aminolevulinate synthase 2
decreases expression
EXP
linalool results in decreased expression of ALAS2 mRNA
CTD
PMID:20536181
NCBI chr X:19,463,146...19,486,526
Ensembl chr X:19,463,171...19,486,519
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Aph1b
aph-1 homolog B, gamma secretase subunit
decreases expression
EXP
linalool results in decreased expression of APH1B mRNA
CTD
PMID:20536181
NCBI chr 8:67,429,198...67,454,735
Ensembl chr 8:67,429,198...67,450,243
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Apoa1
apolipoprotein A1
increases expression
ISO
linalool results in increased expression of APOA1 mRNA
CTD
PMID:24752549
NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
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Apoc3
apolipoprotein C3
decreases expression
ISO
linalool results in decreased expression of APOC3 mRNA; linalool results in decreased expression of APOC3 protein
CTD
PMID:24752549
NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583
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Ar
androgen receptor
multiple interactions
ISO
linalool inhibits the reaction [Testosterone results in increased activity of AR protein]
CTD
PMID:31393563
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Atf2
activating transcription factor 2
increases expression
ISO
linalool results in increased expression of ATF2 mRNA
CTD
PMID:19922762
NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
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Bak1
BCL2-antagonist/killer 1
increases expression
ISO
linalool results in increased expression of BAK1 mRNA
CTD
PMID:28567457
NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
linalool results in increased expression of BAX mRNA
CTD
PMID:26703569 PMID:28567457
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
linalool results in decreased expression of BCL2 mRNA
CTD
PMID:28567457
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bcl2l1
Bcl2-like 1
decreases expression
ISO
linalool results in decreased expression of BCL2L1 mRNA
CTD
PMID:28567457
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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Birc2
baculoviral IAP repeat-containing 2
increases expression
ISO
linalool results in increased expression of BIRC2 mRNA
CTD
PMID:19922762
NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
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Birc3
baculoviral IAP repeat-containing 3
increases expression
ISO
linalool results in increased expression of BIRC3 mRNA
CTD
PMID:19922762
NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
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Casp3
caspase 3
increases expression increases activity
ISO
linalool results in increased expression of CASP3 mRNA linalool results in increased activity of CASP3 protein
CTD
PMID:26703569 PMID:28567457
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp8
caspase 8
increases expression
ISO
linalool results in increased expression of CASP8 mRNA
CTD
PMID:26703569
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Casp9
caspase 9
increases expression increases activity
ISO
linalool results in increased expression of CASP9 mRNA linalool results in increased activity of CASP9 protein
CTD
PMID:26703569 PMID:28567457
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cat
catalase
multiple interactions
EXP
linalool inhibits the reaction [[Phosphates co-treated with Adenine] results in increased expression of CAT protein]
CTD
PMID:30466616
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cd86
CD86 molecule
increases expression
ISO
linalool metabolite results in increased expression of CD86 protein
CTD
PMID:29029310
NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
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Cdh1
cadherin 1
increases expression
ISO
linalool results in increased expression of CDH1 mRNA
CTD
PMID:26703569
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
ISO
linalool results in increased expression of CDKN1A mRNA
CTD
PMID:19922762 PMID:26703569
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cdkn1b
cyclin-dependent kinase inhibitor 1B
increases expression
ISO
linalool results in increased expression of CDKN1B mRNA
CTD
PMID:19922762
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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Cdkn1c
cyclin-dependent kinase inhibitor 1C
increases expression
ISO
linalool results in increased expression of CDKN1C mRNA
CTD
PMID:19922762
NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048
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Cdkn2a
cyclin-dependent kinase inhibitor 2A
increases expression
ISO
linalool results in increased expression of CDKN2A mRNA
CTD
PMID:26703569
NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
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Cdkn2b
cyclin-dependent kinase inhibitor 2B
increases expression
ISO
linalool results in increased expression of CDKN2B mRNA
CTD
PMID:19922762
NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050
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Cdkn2c
cyclin-dependent kinase inhibitor 2C
increases expression
ISO
linalool results in increased expression of CDKN2C mRNA
CTD
PMID:26703569
NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278
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Cebpb
CCAAT/enhancer binding protein beta
increases expression
EXP
linalool results in increased expression of CEBPB mRNA
CTD
PMID:20536181
NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
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Cebpd
CCAAT/enhancer binding protein delta
increases expression
EXP
linalool results in increased expression of CEBPD mRNA
CTD
PMID:20536181
NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829
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Col10a1
collagen type X alpha 1 chain
increases expression
EXP
linalool results in increased expression of COL10A1 mRNA
CTD
PMID:20536181
NCBI chr20:38,183,103...38,189,488
Ensembl chr20:38,182,494...38,189,494
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Csn2
casein beta
increases expression
ISO
linalool results in increased expression of CSN2 mRNA
CTD
PMID:19922762
NCBI chr14:20,322,581...20,329,818
Ensembl chr14:20,322,581...20,329,817
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Ctsd
cathepsin D
increases expression multiple interactions
ISO
linalool results in increased expression of CTSD mRNA Fulvestrant inhibits the reaction [linalool results in increased expression of CTSD mRNA]
CTD
PMID:19922762 PMID:31393563
NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression
ISO
linalool results in increased expression of CYP1A1 mRNA
CTD
PMID:20491607
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp27a1
cytochrome P450, family 27, subfamily a, polypeptide 1
increases expression
ISO
linalool results in increased expression of CYP27A1 mRNA
CTD
PMID:24752549
NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
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Cyp4f6
cytochrome P450, family 4, subfamily f, polypeptide 6
multiple interactions
ISO
linalool inhibits the reaction [Testosterone results in increased expression of CYP4F8 mRNA]
CTD
PMID:31393563
NCBI chr 7:12,030,276...12,058,020
Ensembl chr 7:12,030,301...12,057,782
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Dhcr7
7-dehydrocholesterol reductase
increases expression
ISO
linalool results in increased expression of DHCR7 mRNA
CTD
PMID:24752549
NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055
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Dnajb1
DnaJ heat shock protein family (Hsp40) member B1
increases expression
EXP
linalool results in increased expression of DNAJB1 mRNA
CTD
PMID:20536181
NCBI chr19:24,522,731...24,526,419
Ensembl chr19:24,522,717...24,526,458
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Echs1
enoyl-CoA hydratase, short chain 1
increases expression
ISO
linalool results in increased expression of ECHS1 mRNA
CTD
PMID:24752549
NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884
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Edn1
endothelin 1
increases expression
ISO
linalool results in increased expression of EDN1 mRNA
CTD
PMID:19922762
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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Egfr
epidermal growth factor receptor
increases expression
ISO
linalool results in increased expression of EGFR mRNA
CTD
PMID:19922762
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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Elovl3
ELOVL fatty acid elongase 3
decreases expression
ISO
linalool results in decreased expression of ELOVL3 mRNA
CTD
PMID:24752549
NCBI chr 1:244,997,287...245,001,115
Ensembl chr 1:244,997,287...245,001,115
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Esr1
estrogen receptor 1
increases activity
ISO
linalool results in increased activity of ESR1 protein
CTD
PMID:31393563
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Fabp1
fatty acid binding protein 1
increases expression
ISO
linalool results in increased expression of FABP1 mRNA
CTD
PMID:24752549
NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
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Fn1
fibronectin 1
increases expression
ISO
linalool results in increased expression of FN1 mRNA
CTD
PMID:19922762
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
increases expression
EXP
linalool results in increased expression of FOS mRNA
CTD
PMID:20536181
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Gabbr1
gamma-aminobutyric acid type B receptor subunit 1
increases expression
EXP
linalool results in increased expression of GABBR1 mRNA
CTD
PMID:20536181
NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994
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Gadd45a
growth arrest and DNA-damage-inducible, alpha
increases expression
ISO
linalool results in increased expression of GADD45A mRNA; linalool results in increased expression of GADD45A protein
CTD
PMID:19922762
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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Gclc
glutamate-cysteine ligase, catalytic subunit
increases expression
ISO
linalool results in increased expression of GCLC mRNA
CTD
PMID:20491607
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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Greb1
growth regulating estrogen receptor binding 1
multiple interactions increases expression
ISO
Fulvestrant inhibits the reaction [linalool results in increased expression of GREB1 mRNA]
CTD
PMID:31393563
NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633
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Hbb
hemoglobin subunit beta
decreases expression
EXP
linalool results in decreased expression of HBB mRNA
CTD
PMID:20536181
NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012
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Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
multiple interactions decreases expression
ISO
linalool inhibits the reaction [KAT2B protein binds to HMGCR promoter]; linalool inhibits the reaction [SREBF2 protein binds to HMGCR promoter]; linalool results in decreased expression of and results in increased ubiquitination of HMGCR protein linalool results in decreased expression of HMGCR mRNA; linalool results in decreased expression of HMGCR protein
CTD
PMID:21944868 PMID:24613879
NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
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Hmox1
heme oxygenase 1
increases expression
ISO
linalool metabolite results in increased expression of HMOX1 mRNA
CTD
PMID:29029310
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Homer1
homer scaffold protein 1
increases expression
EXP
linalool results in increased expression of HOMER1 mRNA
CTD
PMID:20536181
NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785
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Hsf1
heat shock transcription factor 1
increases expression
ISO
linalool results in increased expression of HSF1 mRNA
CTD
PMID:19922762
NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
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Hsp90aa1
heat shock protein 90 alpha family class A member 1
increases expression
ISO
linalool results in increased expression of HSP90AA1 mRNA
CTD
PMID:19922762
NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
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Hspa1l
heat shock protein family A (Hsp70) member 1 like
increases expression
EXP
linalool results in increased expression of HSPA1L mRNA
CTD
PMID:20536181
NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571
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Hspa4
heat shock protein family A (Hsp70) member 4
increases expression
ISO
linalool results in increased expression of HSPA4 mRNA
CTD
PMID:19922762
NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001
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Hspb1
heat shock protein family B (small) member 1
increases expression
EXP
linalool results in increased expression of HSPB1 mRNA
CTD
PMID:20536181
NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
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Hspb2
heat shock protein family B (small) member 2
increases expression
ISO
linalool results in increased expression of HSPB2 mRNA
CTD
PMID:19922762
NCBI chr 8:51,093,267...51,094,528
Ensembl chr 8:51,081,342...51,094,533
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Hsph1
heat shock protein family H (Hsp110) member 1
increases expression
EXP
linalool results in increased expression of HSPH1 mRNA
CTD
PMID:20536181
NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224
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Icam1
intercellular adhesion molecule 1
increases expression multiple interactions
ISO
linalool metabolite results in increased expression of ICAM1 protein linalool inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]
CTD
PMID:29029310 PMID:29276222
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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Id2
inhibitor of DNA binding 2
increases expression
ISO
linalool results in increased expression of ID2 mRNA
CTD
PMID:19922762
NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
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Insig1
insulin induced gene 1
increases expression
ISO
linalool results in increased expression of INSIG1 protein
CTD
PMID:21944868
NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952
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Insig2
insulin induced gene 2
increases expression
ISO
linalool results in increased expression of INSIG2 mRNA
CTD
PMID:24752549
NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
increases expression
ISO
linalool results in increased expression of JUN protein
CTD
PMID:19922762
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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Kat2b
lysine acetyltransferase 2B
multiple interactions
ISO
linalool inhibits the reaction [KAT2B protein binds to HMGCR promoter]
CTD
PMID:21944868
NCBI chr 9:6,562,525...6,667,064
Ensembl chr 9:6,562,288...6,667,064
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Lipa
lipase A, lysosomal acid type
increases expression
ISO
linalool results in increased expression of LIPA mRNA
CTD
PMID:24752549
NCBI chr 1:232,024,351...232,057,735
Ensembl chr 1:232,024,356...232,057,633
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Lpl
lipoprotein lipase
increases expression multiple interactions
ISO
linalool results in increased expression of LPL mRNA; linalool results in increased expression of LPL protein PPARA gene mutant form inhibits the reaction [linalool results in increased expression of LPL mRNA]; PPARA gene mutant form inhibits the reaction [linalool results in increased expression of LPL protein] PPARA protein promotes the reaction [linalool results in increased expression of LPL protein]
CTD
PMID:24752549
NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
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Mapk1
mitogen activated protein kinase 1
increases phosphorylation
ISO
linalool metabolite results in increased phosphorylation of MAPK1 protein
CTD
PMID:29029310
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
increases phosphorylation
ISO
linalool metabolite results in increased phosphorylation of MAPK3 protein
CTD
PMID:29029310
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Marcks
myristoylated alanine rich protein kinase C substrate
increases expression
EXP
linalool results in increased expression of MARCKS mRNA
CTD
PMID:20536181
NCBI chr20:40,685,315...40,691,012
Ensembl chr20:40,685,315...40,691,012
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Mcee
methylmalonyl CoA epimerase
decreases expression
ISO
linalool results in decreased expression of MCEE mRNA
CTD
PMID:24752549
NCBI chr 1:117,964,576...117,987,779
Ensembl chr 1:117,964,576...117,988,484
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Mdh2
malate dehydrogenase 2
increases expression
ISO
linalool results in increased expression of MDH mRNA
CTD
PMID:24752549
NCBI chr12:20,894,269...20,907,225
Ensembl chr12:20,894,262...20,907,271
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Mdm2
MDM2 proto-oncogene
increases expression
ISO
linalool results in increased expression of MDM2 mRNA
CTD
PMID:19922762
NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
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Mmp9
matrix metallopeptidase 9
increases expression
ISO
linalool results in increased expression of MMP9 mRNA
CTD
PMID:26703569
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Mpz
myelin protein zero
decreases expression
EXP
linalool results in decreased expression of MPZ mRNA
CTD
PMID:20536181
NCBI chr13:83,570,811...83,576,680
Ensembl chr13:83,570,811...83,576,679
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Myc
MYC proto-oncogene, bHLH transcription factor
increases expression
ISO
linalool results in increased expression of MYC mRNA
CTD
PMID:19922762
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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Nfe2l2
NFE2 like bZIP transcription factor 2
multiple interactions
ISO
linalool metabolite results in increased expression of and results in increased activity of NFE2L2 protein
CTD
PMID:29029310
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nfkb1
nuclear factor kappa B subunit 1
increases expression
ISO
linalool results in increased expression of NFKB1 mRNA
CTD
PMID:19922762
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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Npy
neuropeptide Y
increases expression
EXP ISO
linalool results in increased expression of NPY mRNA linalool results in increased expression of NPY protein
CTD
PMID:22757684
NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
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Nqo1
NAD(P)H quinone dehydrogenase 1
increases expression
ISO
linalool metabolite results in increased expression of NQO1 mRNA
CTD
PMID:29029310
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Pck2
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
increases expression
ISO
linalool results in increased expression of PCK2 mRNA
CTD
PMID:24752549
NCBI chr15:29,027,891...29,036,729
Ensembl chr15:29,027,894...29,037,283
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Pgm1
phosphoglucomutase 1
increases expression
ISO
linalool results in increased expression of PGM1 mRNA
CTD
PMID:24752549
NCBI chr 5:114,595,298...114,654,728
Ensembl chr 5:114,595,293...114,654,728
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Pgr
progesterone receptor
multiple interactions increases expression
ISO
Fulvestrant inhibits the reaction [linalool results in increased expression of PGR mRNA]
CTD
PMID:31393563
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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Phf1
PHD finger protein 1
decreases expression
ISO
linalool results in decreased expression of PHF1 mRNA
CTD
PMID:27683099
NCBI chr20:5,017,765...5,022,872
Ensembl chr20:5,017,893...5,022,871
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Ppara
peroxisome proliferator activated receptor alpha
increases expression increases response to substance decreases response to substance multiple interactions
ISO
linalool results in increased expression of PPARA mRNA; linalool results in increased expression of PPARA protein PPARA protein results in increased susceptibility to linalool PPARA gene mutant form results in decreased susceptibility to linalool linalool binds to and results in increased activity of PPARA protein; PPARA protein promotes the reaction [linalool results in increased expression of ACOX1 protein]; PPARA protein promotes the reaction [linalool results in increased expression of ACSL1 protein]; PPARA protein promotes the reaction [linalool results in increased expression of LPL protein]; PPARA protein promotes the reaction [linalool results in increased expression of SLC27A4 protein]; PPARA protein promotes the reaction [linalool results in increased expression of UCP2 protein] PPARA gene mutant form inhibits the reaction [linalool results in increased expression of ACOX1 mRNA]; PPARA gene mutant form inhibits the reaction [linalool results in increased expression of ACOX1 protein]; PPARA gene mutant form inhibits the reaction [linalool results in increased expression of ACSL1 mRNA]; PPARA gene mutant form inhibits the reaction [linalool results in increased expression of ACSL1 protein]; PPARA gene mutant form inhibits the reaction [linalool results in increased expression of LPL mRNA]; PPARA gene mutant form inhibits the reaction [linalool results in increased expression of LPL protein]; PPARA gene mutant form inhibits the reaction [linalool results in increased expression of SLC27A4 mRNA]; PPARA gene mutant form inhibits the reaction [linalool results in increased expression of SLC27A4 protein]; PPARA gene mutant form inhibits the reaction [linalool results in increased expression of UCP2 mRNA]; PPARA gene mutant form inhibits the reaction [linalool results in increased expression of UCP2 protein]
CTD
PMID:24752549
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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Psmd9
proteasome 26S subunit, non-ATPase 9
increases expression
ISO
linalool results in increased expression of PSMD9 mRNA
CTD
PMID:26703569
NCBI chr12:33,337,182...33,357,468
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Pxmp4
peroxisomal membrane protein 4
decreases expression
EXP
linalool results in decreased expression of PXMP4 mRNA
CTD
PMID:20536181
NCBI chr 3:143,093,371...143,110,620
Ensembl chr 3:143,093,018...143,110,651
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Rgs5
regulator of G-protein signaling 5
increases expression
EXP
linalool results in increased expression of RGS5 mRNA
CTD
PMID:20536181
NCBI chr13:81,848,254...81,885,053
Ensembl chr13:81,836,304...81,885,518
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Runx2
RUNX family transcription factor 2
multiple interactions
EXP
linalool inhibits the reaction [[Phosphates co-treated with Adenine] results in increased expression of RUNX2 mRNA]
CTD
PMID:30466616
NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
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Rusf1
RUS family member 1
increases expression
EXP
linalool results in increased expression of RUSF1 mRNA
CTD
PMID:20536181
NCBI chr 1:182,852,257...182,881,652
Ensembl chr 1:182,852,262...182,880,732
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Ruvbl2
RuvB-like AAA ATPase 2
decreases expression
ISO
linalool results in decreased expression of RUVBL2 mRNA
CTD
PMID:27683099
NCBI chr 1:95,902,014...95,915,247
Ensembl chr 1:95,901,701...95,915,342
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S100a9
S100 calcium binding protein A9
decreases expression
EXP
linalool results in decreased expression of S100A9 mRNA
CTD
PMID:20536181
NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
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Sec14l2
SEC14-like lipid binding 2
multiple interactions
ISO
linalool inhibits the reaction [Testosterone results in increased expression of SEC14L2 mRNA]
CTD
PMID:31393563
NCBI chr14:78,973,805...78,998,480
Ensembl chr14:78,973,808...78,993,788
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Sele
selectin E
multiple interactions
ISO
linalool inhibits the reaction [TNF protein results in increased expression of SELE mRNA]
CTD
PMID:29276222
NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
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Sirt3
sirtuin 3
decreases expression multiple interactions
ISO
linalool results in decreased expression of SIRT3 mRNA; linalool results in decreased expression of SIRT3 protein linalool inhibits the reaction [SOD2 protein binds to SIRT3 protein]
CTD
PMID:28567457
NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808
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Slc20a1
solute carrier family 20 member 1
multiple interactions
EXP
linalool inhibits the reaction [[Phosphates co-treated with Adenine] results in increased expression of SLC20A1 mRNA]
CTD
PMID:30466616
NCBI chr 3:116,427,095...116,441,049
Ensembl chr 3:116,427,098...116,441,051
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Slc27a4
solute carrier family 27 member 4
multiple interactions increases expression
ISO
PPARA gene mutant form inhibits the reaction [linalool results in increased expression of SLC27A4 mRNA]; PPARA gene mutant form inhibits the reaction [linalool results in increased expression of SLC27A4 protein] linalool results in increased expression of SLC27A4 mRNA; linalool results in increased expression of SLC27A4 protein PPARA protein promotes the reaction [linalool results in increased expression of SLC27A4 protein]
CTD
PMID:24752549
NCBI chr 3:13,075,022...13,087,943
Ensembl chr 3:13,075,022...13,087,943
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Slc6a3
solute carrier family 6 member 3
decreases expression
EXP
linalool results in decreased expression of SLC6A3 mRNA
CTD
PMID:20536181
NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
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Sod2
superoxide dismutase 2
multiple interactions
ISO
linalool inhibits the reaction [SOD2 protein binds to SIRT3 protein]; linalool results in decreased activity of and results in increased acetylation of SOD2 protein
CTD
PMID:28567457
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Sox11
SRY-box transcription factor 11
increases expression
EXP
linalool results in increased expression of SOX11 mRNA
CTD
PMID:20536181
NCBI chr 6:44,008,333...44,010,354
Ensembl chr 6:44,008,340...44,010,354
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Spp1
secreted phosphoprotein 1
multiple interactions
EXP
linalool inhibits the reaction [[Phosphates co-treated with Adenine] results in increased expression of SPP1 mRNA]
CTD
PMID:30466616
NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
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Sqle
squalene epoxidase
increases expression
ISO
linalool results in increased expression of SQLE mRNA
CTD
PMID:24752549
NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618
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Srebf2
sterol regulatory element binding transcription factor 2
multiple interactions decreases expression
ISO
linalool inhibits the reaction [SREBF2 protein binds to HMGCR promoter] linalool results in decreased expression of SREBF2 mRNA; linalool results in decreased expression of SREBF2 protein
CTD
PMID:21944868
NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848
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Th
tyrosine hydroxylase
decreases expression
EXP
linalool results in decreased expression of TH mRNA
CTD
PMID:20536181
NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
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Tnf
tumor necrosis factor
multiple interactions
ISO
linalool inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; linalool inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; linalool inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]
CTD
PMID:29276222
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tp53
tumor protein p53
increases expression increases response to substance
ISO
linalool results in increased expression of TP53 mRNA; linalool results in increased expression of TP53 protein TP53 results in increased susceptibility to linalool
CTD
PMID:19922762 PMID:26703569
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Trpa1
transient receptor potential cation channel, subfamily A, member 1
increases activity
ISO
linalool results in increased activity of TRPA1 protein
CTD
PMID:27735854
NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570
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Tshb
thyroid stimulating hormone subunit beta
decreases expression
EXP
linalool results in decreased expression of TSHB mRNA
CTD
PMID:20536181
NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559
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Txn1
thioredoxin 1
increases expression
ISO
linalool results in increased expression of TXN mRNA
CTD
PMID:20491607
NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
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Ucp2
uncoupling protein 2
multiple interactions increases expression
ISO
PPARA protein promotes the reaction [linalool results in increased expression of UCP2 protein] PPARA gene mutant form inhibits the reaction [linalool results in increased expression of UCP2 mRNA]; PPARA gene mutant form inhibits the reaction [linalool results in increased expression of UCP2 protein] linalool results in increased expression of UCP2 mRNA; linalool results in increased expression of UCP2 protein
CTD
PMID:24752549
NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
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Ugt2b15
UDP glucuronosyltransferase family 2 member B15
increases metabolic processing
EXP
UGT2B15 protein results in increased metabolism of linalool
CTD
PMID:7574722
NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589
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Ugt2b34l1
UDP glucuronosyltransferase 2 family, polypeptide B34 like 1
multiple interactions
ISO
linalool inhibits the reaction [Testosterone results in increased expression of UGT2B28 mRNA]
CTD
PMID:31393563
NCBI chr14:21,146,140...21,167,706
Ensembl chr14:21,145,827...21,167,704
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Vcam1
vascular cell adhesion molecule 1
multiple interactions
ISO
linalool inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]
CTD
PMID:29276222
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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Vof16
ischemia related factor vof-16
increases expression
EXP
linalool results in increased expression of VOF16 mRNA
CTD
PMID:20536181
NCBI chr 8:41,953,062...41,955,169
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Wnt1
Wnt family member 1
increases expression
ISO
linalool results in increased expression of WNT1 mRNA
CTD
PMID:19922762
NCBI chr 7:129,938,604...129,942,651
Ensembl chr 7:129,938,604...129,942,651
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Wsb1
WD repeat and SOCS box-containing 1
increases expression
ISO
linalool results in increased expression of WSB1 mRNA
CTD
PMID:19922762
NCBI chr10:64,202,761...64,219,039
Ensembl chr10:64,202,763...64,219,019
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Ar
androgen receptor
multiple interactions
ISO
linalyl acetate inhibits the reaction [Testosterone results in increased activity of AR protein]
CTD
PMID:31393563
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Ctsd
cathepsin D
increases expression multiple interactions
ISO
linalyl acetate results in increased expression of CTSD mRNA Fulvestrant inhibits the reaction [linalyl acetate results in increased expression of CTSD mRNA]
CTD
PMID:31393563
NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
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Cyp4f6
cytochrome P450, family 4, subfamily f, polypeptide 6
multiple interactions
ISO
linalyl acetate inhibits the reaction [Testosterone results in increased expression of CYP4F8 mRNA]
CTD
PMID:31393563
NCBI chr 7:12,030,276...12,058,020
Ensembl chr 7:12,030,301...12,057,782
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Esr1
estrogen receptor 1
increases activity multiple interactions
ISO
linalyl acetate results in increased activity of ESR1 protein NCOA2 protein promotes the reaction [linalyl acetate results in increased activity of ESR1 protein]
CTD
PMID:31393563
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Greb1
growth regulating estrogen receptor binding 1
increases expression multiple interactions
ISO
linalyl acetate results in increased expression of GREB1 mRNA Fulvestrant inhibits the reaction [linalyl acetate results in increased expression of GREB1 mRNA]
CTD
PMID:31393563
NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633
G
Icam1
intercellular adhesion molecule 1
multiple interactions
ISO
linalyl acetate inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]
CTD
PMID:29276222
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
G
Ncoa2
nuclear receptor coactivator 2
multiple interactions
ISO
NCOA2 protein promotes the reaction [linalyl acetate results in increased activity of ESR1 protein]
CTD
PMID:31393563
NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451
G
Pgr
progesterone receptor
increases expression multiple interactions
ISO
linalyl acetate results in increased expression of PGR mRNA Fulvestrant inhibits the reaction [linalyl acetate results in increased expression of PGR mRNA]
CTD
PMID:31393563
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
linalyl acetate inhibits the reaction [TNF protein results in increased expression of and affects the localization of RELA protein modified form]
CTD
PMID:29276222
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
G
Sec14l2
SEC14-like lipid binding 2
multiple interactions
ISO
linalyl acetate inhibits the reaction [Testosterone results in increased expression of SEC14L2 mRNA]
CTD
PMID:31393563
NCBI chr14:78,973,805...78,998,480
Ensembl chr14:78,973,808...78,993,788
G
Sele
selectin E
multiple interactions
ISO
linalyl acetate inhibits the reaction [TNF protein results in increased expression of SELE mRNA]
CTD
PMID:29276222
NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
G
Selp
selectin P
multiple interactions
ISO
linalyl acetate inhibits the reaction [TNF protein results in increased expression of SELP mRNA]
CTD
PMID:29276222
NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845
G
Tnf
tumor necrosis factor
multiple interactions
ISO
linalyl acetate inhibits the reaction [TNF protein results in increased expression of and affects the localization of RELA protein modified form]; linalyl acetate inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; linalyl acetate inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; linalyl acetate inhibits the reaction [TNF protein results in increased expression of SELP mRNA]; linalyl acetate inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]
CTD
PMID:29276222
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Ugt2b34l1
UDP glucuronosyltransferase 2 family, polypeptide B34 like 1
multiple interactions
ISO
linalyl acetate inhibits the reaction [Testosterone results in increased expression of UGT2B28 mRNA]
CTD
PMID:31393563
NCBI chr14:21,146,140...21,167,706
Ensembl chr14:21,145,827...21,167,704
G
Vcam1
vascular cell adhesion molecule 1
multiple interactions
ISO
linalyl acetate inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]
CTD
PMID:29276222
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
G
Ar
androgen receptor
multiple interactions
ISO
linalyl acetate inhibits the reaction [Testosterone results in increased activity of AR protein]
CTD
PMID:31393563
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
G
Ctsd
cathepsin D
increases expression multiple interactions
ISO
linalyl acetate results in increased expression of CTSD mRNA Fulvestrant inhibits the reaction [linalyl acetate results in increased expression of CTSD mRNA]
CTD
PMID:31393563
NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
G
Cyp4f6
cytochrome P450, family 4, subfamily f, polypeptide 6
multiple interactions
ISO
linalyl acetate inhibits the reaction [Testosterone results in increased expression of CYP4F8 mRNA]
CTD
PMID:31393563
NCBI chr 7:12,030,276...12,058,020
Ensembl chr 7:12,030,301...12,057,782
G
Esr1
estrogen receptor 1
multiple interactions increases activity
ISO
NCOA2 protein promotes the reaction [linalyl acetate results in increased activity of ESR1 protein]
CTD
PMID:31393563
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
G
Greb1
growth regulating estrogen receptor binding 1
multiple interactions increases expression
ISO
Fulvestrant inhibits the reaction [linalyl acetate results in increased expression of GREB1 mRNA]
CTD
PMID:31393563
NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633
G
Icam1
intercellular adhesion molecule 1
multiple interactions
ISO
linalyl acetate inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]
CTD
PMID:29276222
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
G
Ncoa2
nuclear receptor coactivator 2
multiple interactions
ISO
NCOA2 protein promotes the reaction [linalyl acetate results in increased activity of ESR1 protein]
CTD
PMID:31393563
NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451
G
Pgr
progesterone receptor
multiple interactions increases expression
ISO
Fulvestrant inhibits the reaction [linalyl acetate results in increased expression of PGR mRNA]
CTD
PMID:31393563
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
linalyl acetate inhibits the reaction [TNF protein results in increased expression of and affects the localization of RELA protein modified form]
CTD
PMID:29276222
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
G
Sec14l2
SEC14-like lipid binding 2
multiple interactions
ISO
linalyl acetate inhibits the reaction [Testosterone results in increased expression of SEC14L2 mRNA]
CTD
PMID:31393563
NCBI chr14:78,973,805...78,998,480
Ensembl chr14:78,973,808...78,993,788
G
Sele
selectin E
multiple interactions
ISO
linalyl acetate inhibits the reaction [TNF protein results in increased expression of SELE mRNA]
CTD
PMID:29276222
NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
G
Selp
selectin P
multiple interactions
ISO
linalyl acetate inhibits the reaction [TNF protein results in increased expression of SELP mRNA]
CTD
PMID:29276222
NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845
G
Tnf
tumor necrosis factor
multiple interactions
ISO
linalyl acetate inhibits the reaction [TNF protein results in increased expression of and affects the localization of RELA protein modified form]; linalyl acetate inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; linalyl acetate inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; linalyl acetate inhibits the reaction [TNF protein results in increased expression of SELP mRNA]; linalyl acetate inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]
CTD
PMID:29276222
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Ugt2b34l1
UDP glucuronosyltransferase 2 family, polypeptide B34 like 1
multiple interactions
ISO
linalyl acetate inhibits the reaction [Testosterone results in increased expression of UGT2B28 mRNA]
CTD
PMID:31393563
NCBI chr14:21,146,140...21,167,706
Ensembl chr14:21,145,827...21,167,704
G
Vcam1
vascular cell adhesion molecule 1
multiple interactions
ISO
linalyl acetate inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]
CTD
PMID:29276222
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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