Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:biochanin A
go back to main search page
Accession:CHEBI:17574 term browser browse the term
Definition:A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone which is substituted by an additional hydroxy group at position 5 and a methoxy group at position 4'. A phytoestrogen, it has putative benefits in dietary cancer prophylaxis.
Synonyms:exact_synonym: 5,7-dihydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one
 related_synonym: 4'-methylgenistein;   5,7-dihydroxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one;   5,7-dihydroxy-3-p-methoxyphenyl-4H-chromen-4-one;   5,7-dihydroxy-4'-methoxyisoflavone;   Formula=C16H12O5;   InChI=1S/C16H12O5/c1-20-11-4-2-9(3-5-11)12-8-21-14-7-10(17)6-13(18)15(14)16(12)19/h2-8,17-18H,1H3;   InChIKey=WUADCCWRTIWANL-UHFFFAOYSA-N;   SMILES=COc1ccc(cc1)-c1coc2cc(O)cc(O)c2c1=O;   olmelin;   pratensol
 alt_id: CHEBI:13903;   CHEBI:22876;   CHEBI:3105
 xref: Beilstein:278107;   CAS:491-80-5;   HMDB:HMDB0002338;   KEGG:C00814;   KNApSAcK:C00002510;   LIPID_MAPS_instance:LMPK12050229
 xref_mesh: MESH:C004541
 xref: MetaCyc:BIOCHANIN-A;   PDBeChem:QSO;   PMID:11348577;   PMID:11931850;   PMID:15277096;   PMID:18060767;   PMID:20590565;   PMID:23406166;   PMID:23649249;   PMID:23948065;   PMID:24129051;   PMID:24201306;   PMID:28166217;   PMID:8947298;   Reaxys:278107;   Wikipedia:Biochanin_A
 cyclic_relationship: is_conjugate_acid_of CHEBI:58194


show annotations for term's descendants           Sort by:
 
biochanin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 decreases activity ISO biochanin A results in decreased activity of ABCC1 protein CTD PMID:15581599 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO biochanin A inhibits the reaction [ABCC2 protein affects the export of ochratoxin A] CTD PMID:15955639 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Agrn agrin decreases expression ISO biochanin A results in decreased expression of AGRN mRNA CTD PMID:12111696 NCBI chr 5:173,589,910...173,622,813
Ensembl chr 5:173,589,819...173,622,645
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases activity
affects binding
ISO
EXP
AHR protein affects the reaction [biochanin A results in increased expression of CYP1A1 mRNA]; AHR protein affects the reaction [biochanin A results in increased expression of CYP1B1 mRNA]; biochanin A inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene promotes the reaction [AHR protein binds to CYP1A1 promoter]]; biochanin A promotes the reaction [AHR protein binds to CYP1A1 promoter]
biochanin A results in increased activity of AHR protein
biochanin A binds to AHR protein
CTD PMID:16903077, PMID:28985473, PMID:31621310 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Aldh7a1 aldehyde dehydrogenase 7 family, member A1 decreases expression ISO biochanin A results in decreased expression of ALDH7A1 mRNA CTD PMID:12111696 NCBI chr18:51,619,007...51,651,267
Ensembl chr18:51,619,007...51,651,267
JBrowse link
G Arid5b AT-rich interaction domain 5B increases expression ISO biochanin A results in increased expression of ARID5B mRNA CTD PMID:12111696 NCBI chr20:21,713,900...21,881,193
Ensembl chr20:21,564,975...21,880,715
JBrowse link
G Babam2 BRISC and BRCA1 A complex member 2 increases expression ISO biochanin A results in increased expression of BABAM2 mRNA CTD PMID:12111696 NCBI chr 6:25,666,654...26,135,888
Ensembl chr 6:25,666,655...26,051,229
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO biochanin A results in decreased expression of BCL2 protein CTD PMID:12791511 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO biochanin A results in decreased expression of BCL2L1 protein CTD PMID:12791511 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp3 caspase 3 increases activity ISO biochanin A results in increased activity of CASP3 protein CTD PMID:12791511 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cdh2 cadherin 2 decreases expression ISO biochanin A results in decreased expression of CDH2 mRNA CTD PMID:12111696 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO biochanin A results in decreased expression of CDKN1A protein CTD PMID:12111696 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Ckb creatine kinase B increases activity ISO biochanin A results in increased activity of CKB protein CTD PMID:16621514 NCBI chr 6:136,142,956...136,145,838
Ensembl chr 6:136,142,956...136,145,837
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions
decreases expression
decreases activity
ISO [Genistein co-treated with biochanin A co-treated with daidzein] results in decreased activity of CYP19A1 protein; [Genistein co-treated with biochanin A co-treated with daidzein] results in decreased expression of CYP19A1 mRNA; biochanin A binds to and results in decreased activity of CYP19A1 protein
biochanin A results in decreased expression of CYP19A1 mRNA
biochanin A results in decreased activity of CYP19A1 protein
CTD PMID:9435150, PMID:16965912 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases hydroxylation
decreases methylation
increases expression
increases activity
ISO AHR protein affects the reaction [biochanin A results in increased expression of CYP1A1 mRNA]; biochanin A inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene promotes the reaction [AHR protein binds to CYP1A1 promoter]]; biochanin A inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased activity of CYP1A1 protein]; biochanin A inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A1 mRNA]; biochanin A promotes the reaction [AHR protein binds to CYP1A1 promoter]; Fulvestrant promotes the reaction [biochanin A results in increased expression of CYP1A1 mRNA]; Sodium Acetate promotes the reaction [biochanin A results in increased expression of CYP1A1 mRNA]
CYP1A1 protein results in increased hydroxylation of biochanin A
CYP1A1 protein results in decreased methylation of biochanin A
biochanin A results in increased activity of CYP1A1 protein
CTD PMID:15479032, PMID:16903077, PMID:28985473, PMID:31621310 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing
decreases activity
ISO
EXP
CYP1A2 protein results in increased metabolism of biochanin A
biochanin A results in decreased activity of CYP1A2 protein
CTD PMID:12814970, PMID:26278343 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases methylation
multiple interactions
increases expression
ISO CYP1B1 protein results in decreased methylation of biochanin A
Sodium Acetate promotes the reaction [biochanin A results in increased expression of CYP1B1 mRNA]
AHR protein affects the reaction [biochanin A results in increased expression of CYP1B1 mRNA]; Butyric Acid promotes the reaction [biochanin A results in increased expression of CYP1B1 mRNA]; Sodium Acetate promotes the reaction [biochanin A results in increased expression of CYP1B1 mRNA]; sodium propionate promotes the reaction [biochanin A results in increased expression of CYP1B1 mRNA]
CTD PMID:15479032, PMID:28985473, PMID:31621310 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 affects activity
increases activity
increases expression
affects expression
ISO biochanin A affects the activity of CYP27B1 protein
biochanin A analog results in increased activity of CYP27B1 protein; biochanin A results in increased activity of CYP27B1 protein
biochanin A analog results in increased expression of CYP27B1 mRNA; biochanin A results in increased expression of CYP27B1 mRNA
biochanin A affects the expression of CYP27B1 mRNA; biochanin A analog affects the expression of CYP27B1 mRNA
CTD PMID:15795327, PMID:17659868 NCBI chr 7:70,333,150...70,340,006
Ensembl chr 7:70,335,061...70,340,005
JBrowse link
G Dera deoxyribose-phosphate aldolase decreases expression ISO biochanin A results in decreased expression of DERA mRNA CTD PMID:12111696 NCBI chr 4:171,748,254...171,826,414
Ensembl chr 4:171,748,273...171,826,409
JBrowse link
G Eif5 eukaryotic translation initiation factor 5 decreases expression ISO biochanin A results in decreased expression of EIF5 mRNA CTD PMID:12111696 NCBI chr 6:136,002,983...136,011,409
Ensembl chr 6:136,004,214...136,011,406
JBrowse link
G Enpp5 ectonucleotide pyrophosphatase/phosphodiesterase family member 5 decreases expression ISO biochanin A results in decreased expression of ENPP5 mRNA CTD PMID:12111696 NCBI chr 9:19,469,276...19,476,684
Ensembl chr 9:19,469,706...19,476,646
JBrowse link
G Eps15 epidermal growth factor receptor pathway substrate 15 decreases expression ISO biochanin A results in decreased expression of EPS15 mRNA CTD PMID:12111696 NCBI chr 5:128,923,809...129,022,268
Ensembl chr 5:128,923,934...129,022,054
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
affects binding
ISO biochanin A binds to and results in increased activity of ESR1 protein; biochanin A inhibits the reaction [Estradiol binds to ESR1 protein]
biochanin A binds to ESR1 protein
CTD PMID:9751507, PMID:12598185, PMID:14579009, PMID:16076101, PMID:19913605 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
affects binding
ISO
EXP
biochanin A binds to and results in increased activity of ESR2 protein; biochanin A inhibits the reaction [Estradiol binds to ESR2 protein]
biochanin A binds to ESR2 protein
CTD PMID:9751507, PMID:12224631, PMID:16076101, PMID:16566672, PMID:19913605 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions
affects binding
ISO biochanin A binds to and results in increased activity of ESRRA protein; biochanin A promotes the reaction [ESRRA protein binds to PNRC1 protein]
biochanin A binds to ESRRA protein mutant form
CTD PMID:14638870 NCBI chr 1:222,168,729...222,178,842
Ensembl chr 1:222,168,730...222,178,725
JBrowse link
G Esrrb estrogen-related receptor beta multiple interactions ISO biochanin A binds to and results in increased activity of ESRRB protein; biochanin A promotes the reaction [ESRRB protein binds to PNRC1 protein] CTD PMID:14638870 NCBI chr 6:110,360,940...110,458,406
Ensembl chr 6:110,410,141...110,455,906
JBrowse link
G Esrrg estrogen-related receptor gamma multiple interactions ISO biochanin A promotes the reaction [ESRRG protein binds to PNRC1 protein] CTD PMID:14638870 NCBI chr13:106,063,799...106,683,353
Ensembl chr13:106,463,368...106,683,436
JBrowse link
G Fbl fibrillarin increases expression ISO biochanin A results in increased expression of FBL mRNA CTD PMID:12111696 NCBI chr 1:85,103,519...85,112,619
Ensembl chr 1:85,103,519...85,112,619
JBrowse link
G Folr1 folate receptor alpha decreases expression ISO biochanin A results in decreased expression of FOLR1 mRNA CTD PMID:12111696 NCBI chr 1:166,934,457...166,945,864
Ensembl chr 1:166,934,460...166,943,592
JBrowse link
G Gm2a GM2 ganglioside activator decreases expression ISO biochanin A results in decreased expression of GM2A mRNA CTD PMID:12111696 NCBI chr10:40,438,394...40,450,927
Ensembl chr10:40,438,356...40,450,930
JBrowse link
G Gnai3 G protein subunit alpha i3 decreases expression ISO biochanin A results in decreased expression of GNAI3 mRNA CTD PMID:12111696 NCBI chr 2:210,896,779...210,934,733
Ensembl chr 2:210,896,656...210,934,749
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression ISO biochanin A results in decreased expression of GPX1 mRNA CTD PMID:12111696 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO biochanin A inhibits the reaction [CXCL8 protein results in increased expression of ICAM1 protein] CTD PMID:22387535 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il17a interleukin 17A multiple interactions ISO biochanin A promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA] CTD PMID:25583575 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il4 interleukin 4 increases expression ISO biochanin A results in increased expression of IL4 mRNA; biochanin A results in increased expression of IL4 protein CTD PMID:16169028 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase multiple interactions ISO biochanin A inhibits the reaction [CXCL8 protein results in increased phosphorylation of LCK protein] CTD PMID:22387535 NCBI chr 5:147,750,976...147,779,627
Ensembl chr 5:147,750,973...147,761,983
JBrowse link
G Ldlrad4 low density lipoprotein receptor class A domain containing 4 decreases expression ISO biochanin A results in decreased expression of LDLRAD4 mRNA CTD PMID:12111696 NCBI chr18:63,717,423...64,045,224
Ensembl chr18:63,882,610...64,044,023
JBrowse link
G Lxn latexin increases expression ISO biochanin A results in increased expression of LXN mRNA CTD PMID:12111696 NCBI chr 2:164,628,565...164,634,434
Ensembl chr 2:164,628,566...164,634,434
JBrowse link
G Mmp14 matrix metallopeptidase 14 decreases expression ISO biochanin A results in decreased expression of MMP14 protein CTD PMID:16598420 NCBI chr15:33,074,441...33,083,666
Ensembl chr15:33,074,441...33,083,655
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases activity ISO biochanin A results in decreased activity of MMP2 protein CTD PMID:16598420 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases activity ISO biochanin A results in decreased activity of MMP9 protein CTD PMID:16598420 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mt2A metallothionein 2A increases expression ISO biochanin A results in increased expression of MT2A mRNA CTD PMID:10656621 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO biochanin A promotes the reaction [RORC protein binds to NCOA1 protein] CTD PMID:25583575 NCBI chr 6:28,677,563...28,931,844
Ensembl chr 6:28,677,540...28,931,843
JBrowse link
G Ndufa5 NADH:ubiquinone oxidoreductase subunit A5 decreases expression ISO biochanin A results in decreased expression of NDUFA5 mRNA CTD PMID:12111696 NCBI chr 4:51,590,413...51,598,771
Ensembl chr 4:51,590,413...51,598,771
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO biochanin A inhibits the reaction [CXCL8 protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; biochanin A inhibits the reaction [pervanadate results in increased phosphorylation of NFKBIA protein] CTD PMID:22387535 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nono non-POU domain containing, octamer-binding decreases expression ISO biochanin A results in decreased expression of NONO mRNA CTD PMID:12111696 NCBI chr  X:71,324,365...71,342,225
Ensembl chr  X:71,324,365...71,342,225
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO biochanin A inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO biochanin A results in increased cleavage of PARP1 protein CTD PMID:12791511 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pfdn5 prefoldin subunit 5 decreases expression ISO biochanin A results in decreased expression of PFDN5 mRNA CTD PMID:12111696 NCBI chr 7:143,924,662...143,929,400
Ensembl chr 7:143,924,662...143,929,397
JBrowse link
G Pgr progesterone receptor affects binding
increases expression
multiple interactions
ISO biochanin A binds to PGR protein
biochanin A results in increased expression of PGR mRNA
biochanin A inhibits the reaction [Progesterone binds to PGR protein]
CTD PMID:14579009, PMID:16076101 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Plaur plasminogen activator, urokinase receptor decreases expression ISO biochanin A results in decreased expression of PLAUR protein CTD PMID:16598420 NCBI chr 1:81,328,171...81,344,954
Ensembl chr 1:81,328,183...81,344,708
JBrowse link
G Pnrc1 proline-rich nuclear receptor coactivator 1 multiple interactions ISO biochanin A promotes the reaction [ESRRA protein binds to PNRC1 protein]; biochanin A promotes the reaction [ESRRB protein binds to PNRC1 protein]; biochanin A promotes the reaction [ESRRG protein binds to PNRC1 protein] CTD PMID:14638870 NCBI chr 5:48,501,472...48,504,511
Ensembl chr 5:48,501,472...48,504,511
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO biochanin A inhibits the reaction [CXCL8 protein results in increased expression of PTGS2 protein] CTD PMID:22387535 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rabl6 RAB, member RAS oncogene family-like 6 decreases expression ISO biochanin A results in decreased expression of RABL6 mRNA CTD PMID:12111696 NCBI chr 3:2,806,777...2,832,697
Ensembl chr 3:2,806,777...2,832,697
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO biochanin A results in decreased expression of RELA mRNA CTD PMID:12111696 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rif1 replication timing regulatory factor 1 decreases expression ISO biochanin A results in decreased expression of RIF1 mRNA CTD PMID:12111696 NCBI chr 3:37,599,540...37,648,818
Ensembl chr 3:37,599,728...37,647,631
JBrowse link
G Rorc RAR-related orphan receptor C multiple interactions ISO biochanin A promotes the reaction [RORC protein binds to NCOA1 protein] CTD PMID:25583575 NCBI chr 2:195,612,471...195,636,797
Ensembl chr 2:195,617,021...195,637,630
JBrowse link
G Rpusd3 RNA pseudouridine synthase D3 decreases expression ISO biochanin A results in decreased expression of RPUSD3 mRNA CTD PMID:12111696 NCBI chr 4:145,361,937...145,370,992
Ensembl chr 4:145,366,765...145,370,992
JBrowse link
G Sh3gl1 SH3 domain containing GRB2 like 1, endophilin A2 increases expression ISO biochanin A results in increased expression of SH3GL1 mRNA CTD PMID:12111696 NCBI chr 9:11,031,847...11,055,285
Ensembl chr 9:11,031,841...11,055,285
JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions EXP [biochanin A results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate CTD PMID:17108059 NCBI chr 2:207,108,552...207,129,352
Ensembl chr 2:207,108,552...207,128,554
JBrowse link
G Slc25a3 solute carrier family 25 member 3 decreases expression ISO biochanin A results in decreased expression of SLC25A3 mRNA CTD PMID:12111696 NCBI chr 7:31,816,601...31,824,064
Ensembl chr 7:31,816,602...31,824,071
JBrowse link
G Slco1a1 solute carrier organic anion transporter family, member 1a1 decreases activity
multiple interactions
EXP biochanin A results in decreased activity of SLCO1B1 protein
[biochanin A results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan; [biochanin A results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Methotrexate
CTD PMID:32259555 NCBI chr 4:176,158,174...176,231,331
Ensembl chr 4:176,158,640...176,231,344
JBrowse link
G Srsf1 serine and arginine rich splicing factor 1 decreases expression ISO biochanin A results in decreased expression of SRSF1 mRNA CTD PMID:12111696 NCBI chr10:75,334,200...75,341,197
Ensembl chr10:75,335,146...75,341,197
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases expression EXP biochanin A results in increased expression of SULT1A1 mRNA; biochanin A results in increased expression of SULT1A1 protein CTD PMID:20391625 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 increases expression EXP biochanin A results in increased expression of SULT1E1 mRNA; biochanin A results in increased expression of SULT1E1 protein CTD PMID:20391625 NCBI chr14:22,070,861...22,089,264
Ensembl chr14:22,072,024...22,089,248
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 increases expression EXP biochanin A results in increased expression of SULT2A1 mRNA; biochanin A results in increased expression of SULT2A1 protein CTD PMID:20391625 NCBI chr 1:76,558,721...76,614,315
Ensembl chr 1:76,252,329...76,780,230
JBrowse link
G Susd6 sushi domain containing 6 increases expression ISO biochanin A results in increased expression of SUSD6 mRNA CTD PMID:12111696 NCBI chr 6:104,437,104...104,532,522
Ensembl chr 6:104,437,159...104,530,403
JBrowse link
G Syk spleen associated tyrosine kinase multiple interactions ISO biochanin A inhibits the reaction [CXCL8 protein results in increased phosphorylation of SYK protein] CTD PMID:22387535 NCBI chr17:12,614,311...12,669,568
Ensembl chr17:12,614,311...12,669,573
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP biochanin A inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:16735947 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf21 TNF receptor superfamily member 21 decreases expression ISO biochanin A results in decreased expression of TNFRSF21 mRNA CTD PMID:12111696 NCBI chr 9:20,546,159...20,621,051
Ensembl chr 9:20,546,159...20,621,051
JBrowse link
G Tubb5 tubulin, beta 5 class I increases expression ISO biochanin A results in increased expression of TUBB mRNA CTD PMID:12111696 NCBI chr20:3,422,448...3,426,420
Ensembl chr20:3,422,461...3,426,371
JBrowse link
G Tyr tyrosinase increases expression ISO biochanin A results in increased expression of TYR mRNA CTD PMID:21071833 NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802
JBrowse link
G Ube2d2 ubiquitin-conjugating enzyme E2D 2 decreases expression ISO biochanin A results in decreased expression of UBE2D2 mRNA CTD PMID:12111696 NCBI chr18:28,561,957...28,603,335
Ensembl chr18:28,594,892...28,603,335
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation
increases expression
ISO UGT1A1 protein results in increased glucuronidation of biochanin A
biochanin A results in increased expression of UGT1A1 mRNA
CTD PMID:14557274, PMID:31621310 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of biochanin A CTD PMID:14557274 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of biochanin A CTD PMID:14557274 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions
decreases expression
EXP biochanin A inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Fulvestrant inhibits the reaction [biochanin A results in decreased expression of VCAM1 protein] CTD PMID:16223672, PMID:16735947 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Wdr74 WD repeat domain 74 decreases expression ISO biochanin A results in decreased expression of WDR74 mRNA CTD PMID:12111696 NCBI chr 1:224,933,906...224,938,659
Ensembl chr 1:224,933,529...224,938,662
JBrowse link
G Wwc2 WW and C2 domain containing 2 decreases expression ISO biochanin A results in decreased expression of WWC2 mRNA CTD PMID:12111696 NCBI chr16:47,368,768...47,533,816
Ensembl chr16:47,368,768...47,533,816
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        pharmaceutical 19272
          drug 19272
            antineoplastic agent 16982
              biochanin A 79
                2,3-dihydrobiochanin A 0
                biochanin A 7-O-(6-O-malonyl-beta-D-glucoside) 0
                biochanin A 7-O-beta-D-glucoside 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      ketone 16140
                                        cyclic ketone 13810
                                          isoflavones 3730
                                            methoxyisoflavone 235
                                              4'-methoxyisoflavones 132
                                                biochanin A 79
                                                  2,3-dihydrobiochanin A 0
                                                  biochanin A 7-O-(6-O-malonyl-beta-D-glucoside) 0
                                                  biochanin A 7-O-beta-D-glucoside 0
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.