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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:biochanin A
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Accession:CHEBI:17574 term browser browse the term
Definition:A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone which is substituted by an additional hydroxy group at position 5 and a methoxy group at position 4'. A phytoestrogen, it has putative benefits in dietary cancer prophylaxis.
Synonyms:exact_synonym: 5,7-dihydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one
 related_synonym: 4'-methylgenistein;   5,7-dihydroxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one;   5,7-dihydroxy-3-p-methoxyphenyl-4H-chromen-4-one;   5,7-dihydroxy-4'-methoxyisoflavone;   Formula=C16H12O5;   InChI=1S/C16H12O5/c1-20-11-4-2-9(3-5-11)12-8-21-14-7-10(17)6-13(18)15(14)16(12)19/h2-8,17-18H,1H3;   InChIKey=WUADCCWRTIWANL-UHFFFAOYSA-N;   SMILES=COc1ccc(cc1)-c1coc2cc(O)cc(O)c2c1=O;   olmelin;   pratensol
 alt_id: CHEBI:13903;   CHEBI:22876;   CHEBI:3105
 xref: CAS:491-80-5;   HMDB:HMDB0002338;   KEGG:C00814;   KNApSAcK:C00002510;   LIPID_MAPS_instance:LMPK12050229
 xref_mesh: MESH:C004541
 xref: MetaCyc:BIOCHANIN-A;   PDBeChem:QSO;   PMID:11348577;   PMID:11931850;   PMID:15277096;   PMID:18060767;   PMID:20590565;   PMID:23406166;   PMID:23649249;   PMID:23948065;   PMID:24129051;   PMID:24201306;   PMID:28166217;   PMID:8947298;   Reaxys:278107;   Wikipedia:Biochanin_A
 cyclic_relationship: is_conjugate_acid_of CHEBI:58194


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biochanin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO biochanin A inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; biochanin A inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; biochanin A promotes the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; biochanin A promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]] CTD PMID:34217736 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases activity ISO biochanin A results in decreased activity of ABCC1 protein CTD PMID:15581599 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO biochanin A inhibits the reaction [ABCC2 protein affects the export of ochratoxin A] CTD PMID:15955639 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Ache acetylcholinesterase multiple interactions ISO [[sodium arsenite results in increased abundance of Arsenic] which co-treated with biochanin A] results in increased activity of ACHE protein; [coenzyme Q10 co-treated with biochanin A co-treated with Phloretin] inhibits the reaction [[sodium arsenite co-treated with Potassium Dichromate] results in decreased activity of ACHE protein]; biochanin A inhibits the reaction [[sodium arsenite co-treated with Potassium Dichromate] results in decreased activity of ACHE protein] CTD PMID:33410021 PMID:35547012 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Agrn agrin decreases expression ISO biochanin A results in decreased expression of AGRN mRNA CTD PMID:12111696 NCBI chr 5:166,749,306...166,782,212
Ensembl chr 5:166,749,310...166,786,003 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases activity
affects binding		 ISO
EXP		 AHR protein affects the reaction [biochanin A results in increased expression of CYP1A1 mRNA]; AHR protein affects the reaction [biochanin A results in increased expression of CYP1B1 mRNA]; biochanin A inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene promotes the reaction [AHR protein binds to CYP1A1 promoter]]; biochanin A promotes the reaction [AHR protein binds to CYP1A1 promoter]
biochanin A results in increased activity of AHR protein
biochanin A binds to AHR protein		 CTD PMID:16903077 PMID:28985473 PMID:31621310 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Aldh7a1 aldehyde dehydrogenase 7 family, member A1 decreases expression ISO biochanin A results in decreased expression of ALDH7A1 mRNA CTD PMID:12111696 NCBI chr18:50,003,242...50,042,193
Ensembl chr18:50,009,934...50,042,193 		JBrowse link
G Arid5b AT-rich interaction domain 5B increases expression ISO biochanin A results in increased expression of ARID5B mRNA CTD PMID:12111696 NCBI chr20:20,307,731...20,490,746
Ensembl chr20:20,307,731...20,487,433 		JBrowse link
G Babam2 BRISC and BRCA1 A complex member 2 increases expression ISO biochanin A results in increased expression of BABAM2 mRNA CTD PMID:12111696 NCBI chr 6:24,369,021...24,788,416
Ensembl chr 6:24,369,022...24,833,951 		JBrowse link
G Bche butyrylcholinesterase multiple interactions ISO [coenzyme Q10 co-treated with biochanin A co-treated with Phloretin] inhibits the reaction [[sodium arsenite co-treated with Potassium Dichromate] results in decreased activity of BCHE protein]; biochanin A inhibits the reaction [[sodium arsenite co-treated with Potassium Dichromate] results in decreased activity of BCHE protein] CTD PMID:35547012 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO biochanin A results in decreased expression of BCL2 protein CTD PMID:12791511 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO biochanin A results in decreased expression of BCL2L1 protein CTD PMID:12791511 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions		 ISO biochanin A results in increased activity of CASP3 protein
biochanin A inhibits the reaction [Dextran Sulfate results in increased cleavage of CASP3 protein]		 CTD PMID:12791511 PMID:38648921 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions ISO biochanin A inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased activity of CAT protein] CTD PMID:33410021 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cdh2 cadherin 2 decreases expression ISO biochanin A results in decreased expression of CDH2 mRNA CTD PMID:12111696 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO biochanin A results in decreased expression of CDKN1A protein CTD PMID:12111696 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Ckb creatine kinase B increases activity ISO biochanin A results in increased activity of CKB protein CTD PMID:16621514 NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315 		JBrowse link
G Cldn1 claudin 1 multiple interactions ISO biochanin A inhibits the reaction [Dextran Sulfate results in decreased expression of CLDN1 protein] CTD PMID:38648921 NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions
decreases expression
decreases activity		 ISO [Genistein co-treated with biochanin A co-treated with daidzein] results in decreased activity of CYP19A1 protein; [Genistein co-treated with biochanin A co-treated with daidzein] results in decreased expression of CYP19A1 mRNA; biochanin A binds to and results in decreased activity of CYP19A1 protein
biochanin A results in decreased expression of CYP19A1 mRNA
biochanin A results in decreased activity of CYP19A1 protein		 CTD PMID:9435150 PMID:16965912 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases hydroxylation
decreases methylation
increases expression
increases activity		 ISO AHR protein affects the reaction [biochanin A results in increased expression of CYP1A1 mRNA]; biochanin A inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene promotes the reaction [AHR protein binds to CYP1A1 promoter]]; biochanin A inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased activity of CYP1A1 protein]; biochanin A inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A1 mRNA]; biochanin A promotes the reaction [AHR protein binds to CYP1A1 promoter]; Fulvestrant promotes the reaction [biochanin A results in increased expression of CYP1A1 mRNA]; Sodium Acetate promotes the reaction [biochanin A results in increased expression of CYP1A1 mRNA]
CYP1A1 protein results in increased hydroxylation of biochanin A
CYP1A1 protein results in decreased methylation of biochanin A
biochanin A results in increased activity of CYP1A1 protein		 CTD PMID:15479032 PMID:16903077 PMID:28985473 PMID:31621310 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing
decreases activity		 ISO
EXP		 CYP1A2 protein results in increased metabolism of biochanin A
biochanin A results in decreased activity of CYP1A2 protein		 CTD PMID:12814970 PMID:26278343 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases methylation
multiple interactions
increases expression		 ISO CYP1B1 protein results in decreased methylation of biochanin A
Sodium Acetate promotes the reaction [biochanin A results in increased expression of CYP1B1 mRNA]
AHR protein affects the reaction [biochanin A results in increased expression of CYP1B1 mRNA]; Butyric Acid promotes the reaction [biochanin A results in increased expression of CYP1B1 mRNA]; Sodium Acetate promotes the reaction [biochanin A results in increased expression of CYP1B1 mRNA]; sodium propionate promotes the reaction [biochanin A results in increased expression of CYP1B1 mRNA]		 CTD PMID:15479032 PMID:28985473 PMID:31621310 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 affects activity
increases activity
increases expression
affects expression		 ISO biochanin A affects the activity of CYP27B1 protein
biochanin A analog results in increased activity of CYP27B1 protein; biochanin A results in increased activity of CYP27B1 protein
biochanin A analog results in increased expression of CYP27B1 mRNA; biochanin A results in increased expression of CYP27B1 mRNA
biochanin A affects the expression of CYP27B1 mRNA; biochanin A analog affects the expression of CYP27B1 mRNA		 CTD PMID:15795327 PMID:17659868 NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241 		JBrowse link
G Dera deoxyribose-phosphate aldolase decreases expression ISO biochanin A results in decreased expression of DERA mRNA CTD PMID:12111696 NCBI chr 4:170,663,689...170,742,469
Ensembl chr 4:170,663,665...170,758,865 		JBrowse link
G Eif5 eukaryotic translation initiation factor 5 decreases expression ISO biochanin A results in decreased expression of EIF5 mRNA CTD PMID:12111696 NCBI chr 6:130,589,162...130,597,656
Ensembl chr 6:130,589,143...130,597,656 		JBrowse link
G Enpp5 ectonucleotide pyrophosphatase/phosphodiesterase family member 5 decreases expression ISO biochanin A results in decreased expression of ENPP5 mRNA CTD PMID:12111696 NCBI chr 9:16,910,187...16,917,633
Ensembl chr 9:16,910,831...16,917,480 		JBrowse link
G Eps15 epidermal growth factor receptor pathway substrate 15 decreases expression ISO biochanin A results in decreased expression of EPS15 mRNA CTD PMID:12111696 NCBI chr 5:124,045,865...124,146,221
Ensembl chr 5:124,045,926...124,146,221 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
decreases expression
affects binding		 ISO
EXP		 biochanin A binds to and results in increased activity of ESR1 protein; biochanin A inhibits the reaction [Estradiol binds to ESR1 protein]
biochanin A results in decreased expression of ESR1 protein
[Fulvestrant co-treated with biochanin A] results in decreased expression of ESR1 protein; [Fulvestrant co-treated with biochanin A] results in increased expression of ESR1 mRNA
biochanin A binds to ESR1 protein		 CTD PMID:9751507 PMID:12598185 PMID:14579009 PMID:16076101 PMID:19913605 More... NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
increases expression
decreases expression
affects binding		 ISO
EXP		 biochanin A binds to and results in increased activity of ESR2 protein; biochanin A inhibits the reaction [Estradiol binds to ESR2 protein]
[Fulvestrant co-treated with biochanin A] results in increased expression of ESR2 mRNA; Fulvestrant inhibits the reaction [biochanin A results in decreased expression of ESR2 protein]
biochanin A results in increased expression of ESR2 mRNA
biochanin A binds to ESR2 protein		 CTD PMID:9751507 PMID:12224631 PMID:16076101 PMID:16566672 PMID:19913605 More... NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions
affects binding		 ISO biochanin A binds to and results in increased activity of ESRRA protein; biochanin A promotes the reaction [ESRRA protein binds to PNRC1 protein]
biochanin A binds to ESRRA protein mutant form		 CTD PMID:14638870 NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268 		JBrowse link
G Esrrb estrogen-related receptor beta multiple interactions ISO biochanin A binds to and results in increased activity of ESRRB protein; biochanin A promotes the reaction [ESRRB protein binds to PNRC1 protein] CTD PMID:14638870 NCBI chr 6:106,007,701...106,163,136
Ensembl chr 6:106,008,095...106,160,791 		JBrowse link
G Esrrg estrogen-related receptor gamma multiple interactions ISO biochanin A promotes the reaction [ESRRG protein binds to PNRC1 protein] CTD PMID:14638870 NCBI chr13:99,167,656...99,788,016
Ensembl chr13:99,564,669...99,783,397 		JBrowse link
G Fbl fibrillarin increases expression ISO biochanin A results in increased expression of FBL mRNA CTD PMID:12111696 NCBI chr 1:83,469,832...83,478,932
Ensembl chr 1:83,469,832...83,478,932 		JBrowse link
G Folr1 folate receptor alpha decreases expression ISO biochanin A results in decreased expression of FOLR1 mRNA CTD PMID:12111696 NCBI chr 1:156,219,460...156,238,436
Ensembl chr 1:156,219,460...156,230,667 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase affects binding
decreases activity
decreases expression		 ISO biochanin A binds to G6PD protein
biochanin A results in decreased activity of G6PD protein
biochanin A results in decreased expression of G6PD mRNA		 CTD PMID:38266663 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gm2a ganglioside GM2 activator decreases expression ISO biochanin A results in decreased expression of GM2A mRNA CTD PMID:12111696 NCBI chr10:39,219,221...39,231,756
Ensembl chr10:39,219,243...39,231,757 		JBrowse link
G Gnai3 G protein subunit alpha i3 decreases expression ISO biochanin A results in decreased expression of GNAI3 mRNA CTD PMID:12111696 NCBI chr 2:195,742,765...195,780,720
Ensembl chr 2:195,742,642...195,780,742 		JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression ISO biochanin A results in decreased expression of GPX1 mRNA CTD PMID:12111696 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO biochanin A inhibits the reaction [CXCL8 protein results in increased expression of ICAM1 protein] CTD PMID:22387535 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions EXP [Fulvestrant co-treated with biochanin A] results in decreased expression of IGF1 mRNA CTD PMID:34848279 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO biochanin A inhibits the reaction [Dextran Sulfate results in decreased expression of IL10 protein] CTD PMID:38648921 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO biochanin A promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA] CTD PMID:25583575 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO biochanin A inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein] CTD PMID:38648921 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il4 interleukin 4 increases expression ISO biochanin A results in increased expression of IL4 mRNA; biochanin A results in increased expression of IL4 protein CTD PMID:16169028 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO biochanin A inhibits the reaction [Isoproterenol results in increased expression of IL6 mRNA] CTD PMID:37016276 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase multiple interactions ISO biochanin A inhibits the reaction [CXCL8 protein results in increased phosphorylation of LCK protein] CTD PMID:22387535 NCBI chr 5:141,888,318...141,916,945
Ensembl chr 5:141,888,326...141,903,794 		JBrowse link
G Ldlrad4 low density lipoprotein receptor class A domain containing 4 decreases expression ISO biochanin A results in decreased expression of LDLRAD4 mRNA CTD PMID:12111696 NCBI chr18:61,519,253...61,848,403
Ensembl chr18:61,521,428...61,843,238 		JBrowse link
G Lxn latexin increases expression ISO biochanin A results in increased expression of LXN mRNA CTD PMID:12111696 NCBI chr 2:151,727,556...151,733,426
Ensembl chr 2:151,727,102...151,733,460 		JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions ISO biochanin A inhibits the reaction [Dextran Sulfate results in decreased expression of MKI67 protein] CTD PMID:38648921 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mmp14 matrix metallopeptidase 14 decreases expression ISO biochanin A results in decreased expression of MMP14 protein CTD PMID:16598420 NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases activity
decreases expression		 ISO biochanin A results in decreased activity of MMP2 protein
biochanin A results in decreased expression of MMP2 mRNA		 CTD PMID:16598420 PMID:38266663 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases activity
decreases expression		 ISO biochanin A results in decreased activity of MMP9 protein
biochanin A results in decreased expression of MMP9 mRNA		 CTD PMID:16598420 PMID:38266663 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO biochanin A inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein] CTD PMID:38648921 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mt2A metallothionein 2A increases expression ISO biochanin A results in increased expression of MT2A mRNA CTD PMID:10656621 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO biochanin A inhibits the reaction [Dextran Sulfate results in increased phosphorylation of MTOR protein] CTD PMID:38648921 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Muc2 mucin 2, oligomeric mucus/gel-forming multiple interactions ISO biochanin A inhibits the reaction [Dextran Sulfate results in decreased expression of MUC2 protein] CTD PMID:38648921 NCBI chr 1:196,799,494...196,831,740
Ensembl chr 1:196,799,517...196,831,756 		JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO biochanin A promotes the reaction [RORC protein binds to NCOA1 protein] CTD PMID:25583575 NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664 		JBrowse link
G Ndufa5 NADH:ubiquinone oxidoreductase subunit A5 decreases expression ISO biochanin A results in decreased expression of NDUFA5 mRNA CTD PMID:12111696 NCBI chr 4:52,997,327...53,005,685
Ensembl chr 4:52,995,546...53,005,598
Ensembl chr 5:52,995,546...53,005,598 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO [[sodium arsenite results in increased abundance of Arsenic] which co-treated with biochanin A] results in increased expression of NFE2L2 mRNA CTD PMID:33410021 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO biochanin A inhibits the reaction [CXCL8 protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; biochanin A inhibits the reaction [pervanadate results in increased phosphorylation of NFKBIA protein] CTD PMID:22387535 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nono non-POU domain containing, octamer-binding decreases expression ISO biochanin A results in decreased expression of NONO mRNA CTD PMID:12111696 NCBI chr  X:66,554,131...66,571,992
Ensembl chr  X:66,554,098...66,571,952 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO biochanin A inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO biochanin A binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Ocln occludin multiple interactions ISO biochanin A inhibits the reaction [Dextran Sulfate results in decreased expression of OCLN protein] CTD PMID:38648921 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150 		JBrowse link
G P2ry14 purinergic receptor P2Y14 decreases expression
multiple interactions		 EXP biochanin A results in decreased expression of P2RY14 mRNA
Fulvestrant inhibits the reaction [biochanin A results in decreased expression of P2RY14 mRNA]		 CTD PMID:34848279 NCBI chr 2:143,372,697...143,413,213
Ensembl chr 2:143,372,697...143,413,141 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO biochanin A results in increased cleavage of PARP1 protein CTD PMID:12791511 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO biochanin A inhibits the reaction [Dextran Sulfate results in decreased expression of PCNA protein] CTD PMID:38648921 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pfdn5 prefoldin subunit 5 decreases expression ISO biochanin A results in decreased expression of PFDN5 mRNA CTD PMID:12111696 NCBI chr 7:133,451,778...133,456,516
Ensembl chr 7:133,451,453...133,456,516 		JBrowse link
G Pgr progesterone receptor affects binding
multiple interactions
increases expression		 ISO
EXP		 biochanin A binds to PGR protein
Fulvestrant inhibits the reaction [biochanin A results in increased expression of PGR mRNA]
biochanin A inhibits the reaction [Progesterone binds to PGR protein]		 CTD PMID:14579009 PMID:16076101 PMID:34848279 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Plaur plasminogen activator, urokinase receptor decreases expression ISO biochanin A results in decreased expression of PLAUR protein CTD PMID:16598420 NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595 		JBrowse link
G Pnrc1 proline-rich nuclear receptor coactivator 1 multiple interactions ISO biochanin A promotes the reaction [ESRRA protein binds to PNRC1 protein]; biochanin A promotes the reaction [ESRRB protein binds to PNRC1 protein]; biochanin A promotes the reaction [ESRRG protein binds to PNRC1 protein] CTD PMID:14638870 NCBI chr 5:47,647,070...47,657,832
Ensembl chr 5:47,647,071...47,650,161 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO biochanin A binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions ISO biochanin A inhibits the reaction [Dextran Sulfate results in decreased phosphorylation of PRKAA1 protein] CTD PMID:38648921 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO biochanin A inhibits the reaction [CXCL8 protein results in increased expression of PTGS2 protein] CTD PMID:22387535 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rabl6 RAB, member RAS oncogene family-like 6 decreases expression ISO biochanin A results in decreased expression of RABL6 mRNA CTD PMID:12111696 NCBI chr 3:8,402,666...8,428,588
Ensembl chr 3:8,402,672...8,428,611 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO biochanin A results in decreased expression of RELA mRNA CTD PMID:12111696 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rif1 replication timing regulatory factor 1 decreases expression ISO biochanin A results in decreased expression of RIF1 mRNA CTD PMID:12111696 NCBI chr 3:36,554,689...36,607,961
Ensembl chr 3:36,554,697...36,603,617 		JBrowse link
G Rorc RAR-related orphan receptor C multiple interactions ISO biochanin A promotes the reaction [RORC protein binds to NCOA1 protein] CTD PMID:25583575 NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907 		JBrowse link
G Rpusd3 RNA pseudouridine synthase D3 decreases expression ISO biochanin A results in decreased expression of RPUSD3 mRNA CTD PMID:12111696 NCBI chr 4:146,553,743...146,562,789
Ensembl chr 4:146,558,562...146,562,794 		JBrowse link
G Sh3gl1 SH3 domain containing GRB2 like 1, endophilin A2 increases expression ISO biochanin A results in increased expression of SH3GL1 mRNA CTD PMID:12111696 NCBI chr 9:842,285...869,753
Ensembl chr 9:842,288...869,716 		JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions EXP [biochanin A results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate CTD PMID:17108059 NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611 		JBrowse link
G Slc25a3 solute carrier family 25 member 3 decreases expression ISO biochanin A results in decreased expression of SLC25A3 mRNA CTD PMID:12111696 NCBI chr 7:25,611,937...25,619,401
Ensembl chr 7:25,586,725...25,667,727 		JBrowse link
G Slco1c1 solute carrier organic anion transporter family, member 1c1 decreases activity
multiple interactions		 EXP biochanin A results in decreased activity of SLCO1B1 protein
[biochanin A results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan; [biochanin A results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Methotrexate		 CTD PMID:32259555 NCBI chr 4:174,466,621...174,513,290
Ensembl chr 4:174,466,631...174,513,289 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO biochanin A inhibits the reaction [Dextran Sulfate results in increased expression of SQSTM1 protein] CTD PMID:38648921 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Srsf1 serine and arginine rich splicing factor 1 decreases expression ISO biochanin A results in decreased expression of SRSF1 mRNA CTD PMID:12111696 NCBI chr10:72,838,926...72,859,066
Ensembl chr10:72,839,274...72,845,336 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases expression EXP biochanin A results in increased expression of SULT1A1 mRNA; biochanin A results in increased expression of SULT1A1 protein CTD PMID:20391625 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 increases expression EXP biochanin A results in increased expression of SULT1E1 mRNA; biochanin A results in increased expression of SULT1E1 protein CTD PMID:20391625 NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 increases expression EXP biochanin A results in increased expression of SULT2A1 mRNA; biochanin A results in increased expression of SULT2A1 protein CTD PMID:20391625 NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134 		JBrowse link
G Susd6 sushi domain containing 6 increases expression ISO biochanin A results in increased expression of SUSD6 mRNA CTD PMID:12111696 NCBI chr 6:100,437,834...100,531,621
Ensembl chr 6:100,437,642...100,531,606 		JBrowse link
G Syk spleen associated tyrosine kinase multiple interactions ISO biochanin A inhibits the reaction [CXCL8 protein results in increased phosphorylation of SYK protein] CTD PMID:22387535 NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO biochanin A binds to and results in increased activity of THRB protein CTD PMID:33049310 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO biochanin A inhibits the reaction [Dextran Sulfate results in decreased expression of TJP1 protein] CTD PMID:38648921 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO		 biochanin A inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
biochanin A inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]		 CTD PMID:16735947 PMID:38648921 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf21 TNF receptor superfamily member 21 decreases expression ISO biochanin A results in decreased expression of TNFRSF21 mRNA CTD PMID:12111696 NCBI chr 9:17,879,156...17,954,085
Ensembl chr 9:17,879,156...17,954,085 		JBrowse link
G Tubb5 tubulin, beta 5 class I increases expression ISO biochanin A results in increased expression of TUBB mRNA CTD PMID:12111696 NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940 		JBrowse link
G Tyr tyrosinase increases expression ISO biochanin A results in increased expression of TYR mRNA CTD PMID:21071833 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207 		JBrowse link
G Ube2d2 ubiquitin-conjugating enzyme E2D 2 decreases expression ISO biochanin A results in decreased expression of UBE2D2 mRNA CTD PMID:12111696 NCBI chr18:27,364,325...27,406,322
Ensembl chr18:27,364,303...27,406,181 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation
increases expression		 ISO UGT1A1 protein results in increased glucuronidation of biochanin A
biochanin A results in increased expression of UGT1A1 mRNA		 CTD PMID:14557274 PMID:31621310 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of biochanin A CTD PMID:14557274 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 multiple interactions ISO biochanin A inhibits the reaction [Dextran Sulfate results in decreased phosphorylation of ULK1 protein] CTD PMID:38648921 NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions
decreases expression		 EXP biochanin A inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Fulvestrant inhibits the reaction [biochanin A results in decreased expression of VCAM1 protein] CTD PMID:16223672 PMID:16735947 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Wdr74 WD repeat domain 74 decreases expression ISO biochanin A results in decreased expression of WDR74 mRNA CTD PMID:12111696 NCBI chr 1:205,631,769...205,636,558
Ensembl chr 1:205,631,824...205,636,563 		JBrowse link
G Wwc2 WW and C2 domain containing 2 decreases expression ISO biochanin A results in decreased expression of WWC2 mRNA CTD PMID:12111696 NCBI chr16:44,258,372...44,421,815
Ensembl chr16:44,258,372...44,421,812 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      application 19689
        pharmaceutical 19525
          drug 19525
            antineoplastic agent 17817
              biochanin A 103
                2,3-dihydrobiochanin A 0
                biochanin A 7-O-(6-O-malonyl-beta-D-glucoside) 0
                biochanin A 7-O-beta-D-glucoside 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            organic molecule 19700
                              organic cyclic compound 19490
                                organic heterocyclic compound 18868
                                  oxacycle 17903
                                    benzopyran 11971
                                      1-benzopyran 11725
                                        isoflavonoid 3827
                                          isoflavones 3808
                                            methoxyisoflavone 312
                                              4'-methoxyisoflavones 206
                                                biochanin A 103
                                                  2,3-dihydrobiochanin A 0
                                                  biochanin A 7-O-(6-O-malonyl-beta-D-glucoside) 0
                                                  biochanin A 7-O-beta-D-glucoside 0
paths to the root