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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:biochanin A
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Accession:CHEBI:17574 term browser browse the term
Definition:A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone which is substituted by an additional hydroxy group at position 5 and a methoxy group at position 4'. A phytoestrogen, it has putative benefits in dietary cancer prophylaxis.
Synonyms:exact_synonym: 5,7-dihydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one
 related_synonym: 4'-methylgenistein;   5,7-dihydroxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one;   5,7-dihydroxy-3-p-methoxyphenyl-4H-chromen-4-one;   5,7-dihydroxy-4'-methoxyisoflavone;   Formula=C16H12O5;   InChI=1S/C16H12O5/c1-20-11-4-2-9(3-5-11)12-8-21-14-7-10(17)6-13(18)15(14)16(12)19/h2-8,17-18H,1H3;   InChIKey=WUADCCWRTIWANL-UHFFFAOYSA-N;   SMILES=COc1ccc(cc1)-c1coc2cc(O)cc(O)c2c1=O;   olmelin;   pratensol
 alt_id: CHEBI:13903;   CHEBI:22876;   CHEBI:3105
 xref: Beilstein:278107;   CAS:491-80-5;   HMDB:HMDB0002338;   KEGG:C00814;   KNApSAcK:C00002510;   LIPID_MAPS_instance:LMPK12050229
 xref_mesh: MESH:C004541
 xref: MetaCyc:BIOCHANIN-A;   PDBeChem:QSO;   PMID:11348577;   PMID:11931850;   PMID:15277096;   PMID:18060767;   PMID:20590565;   PMID:23406166;   PMID:23649249;   PMID:23948065;   PMID:24129051;   PMID:24201306;   PMID:28166217;   PMID:8947298;   Reaxys:278107;   Wikipedia:Biochanin_A
 cyclic_relationship: is_conjugate_acid_of CHEBI:58194


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biochanin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 decreases activity ISO biochanin A results in decreased activity of ABCC1 protein CTD PMID:15581599 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO biochanin A inhibits the reaction [ABCC2 protein affects the export of ochratoxin A] CTD PMID:15955639 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Ache acetylcholinesterase multiple interactions ISO [[sodium arsenite results in increased abundance of Arsenic] which co-treated with biochanin A] results in increased activity of ACHE protein CTD PMID:33410021 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Agrn agrin decreases expression ISO biochanin A results in decreased expression of AGRN mRNA CTD PMID:12111696 NCBI chr 5:166,749,306...166,782,212
Ensembl chr 5:166,749,310...166,786,003
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases activity
affects binding
ISO
EXP
AHR protein affects the reaction [biochanin A results in increased expression of CYP1A1 mRNA]; AHR protein affects the reaction [biochanin A results in increased expression of CYP1B1 mRNA]; biochanin A inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene promotes the reaction [AHR protein binds to CYP1A1 promoter]]; biochanin A promotes the reaction [AHR protein binds to CYP1A1 promoter]
biochanin A results in increased activity of AHR protein
biochanin A binds to AHR protein
CTD PMID:16903077 PMID:28985473 PMID:31621310 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Aldh7a1 aldehyde dehydrogenase 7 family, member A1 decreases expression ISO biochanin A results in decreased expression of ALDH7A1 mRNA CTD PMID:12111696 NCBI chr18:50,003,242...50,042,193
Ensembl chr18:50,009,934...50,042,193
JBrowse link
G Arid5b AT-rich interaction domain 5B increases expression ISO biochanin A results in increased expression of ARID5B mRNA CTD PMID:12111696 NCBI chr20:20,307,731...20,490,746
Ensembl chr20:20,307,731...20,487,433
JBrowse link
G Babam2 BRISC and BRCA1 A complex member 2 increases expression ISO biochanin A results in increased expression of BABAM2 mRNA CTD PMID:12111696 NCBI chr 6:24,369,021...24,833,335
Ensembl chr 6:24,369,022...24,833,951
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO biochanin A results in decreased expression of BCL2 protein CTD PMID:12791511 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO biochanin A results in decreased expression of BCL2L1 protein CTD PMID:12791511 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Casp3 caspase 3 increases activity ISO biochanin A results in increased activity of CASP3 protein CTD PMID:12791511 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase multiple interactions ISO biochanin A inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased activity of CAT protein] CTD PMID:33410021 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cdh2 cadherin 2 decreases expression ISO biochanin A results in decreased expression of CDH2 mRNA CTD PMID:12111696 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO biochanin A results in decreased expression of CDKN1A protein CTD PMID:12111696 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Ckb creatine kinase B increases activity ISO biochanin A results in increased activity of CKB protein CTD PMID:16621514 NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions
decreases expression
decreases activity
ISO [Genistein co-treated with biochanin A co-treated with daidzein] results in decreased activity of CYP19A1 protein; [Genistein co-treated with biochanin A co-treated with daidzein] results in decreased expression of CYP19A1 mRNA; biochanin A binds to and results in decreased activity of CYP19A1 protein
biochanin A results in decreased expression of CYP19A1 mRNA
biochanin A results in decreased activity of CYP19A1 protein
CTD PMID:9435150 PMID:16965912 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases hydroxylation
decreases methylation
increases expression
increases activity
ISO AHR protein affects the reaction [biochanin A results in increased expression of CYP1A1 mRNA]; biochanin A inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene promotes the reaction [AHR protein binds to CYP1A1 promoter]]; biochanin A inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased activity of CYP1A1 protein]; biochanin A inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A1 mRNA]; biochanin A promotes the reaction [AHR protein binds to CYP1A1 promoter]; Fulvestrant promotes the reaction [biochanin A results in increased expression of CYP1A1 mRNA]; Sodium Acetate promotes the reaction [biochanin A results in increased expression of CYP1A1 mRNA]
CYP1A1 protein results in increased hydroxylation of biochanin A
CYP1A1 protein results in decreased methylation of biochanin A
biochanin A results in increased activity of CYP1A1 protein
CTD PMID:15479032 PMID:16903077 PMID:28985473 PMID:31621310 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing
decreases activity
ISO
EXP
CYP1A2 protein results in increased metabolism of biochanin A
biochanin A results in decreased activity of CYP1A2 protein
CTD PMID:12814970 PMID:26278343 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases methylation
multiple interactions
increases expression
ISO CYP1B1 protein results in decreased methylation of biochanin A
Sodium Acetate promotes the reaction [biochanin A results in increased expression of CYP1B1 mRNA]
AHR protein affects the reaction [biochanin A results in increased expression of CYP1B1 mRNA]; Butyric Acid promotes the reaction [biochanin A results in increased expression of CYP1B1 mRNA]; Sodium Acetate promotes the reaction [biochanin A results in increased expression of CYP1B1 mRNA]; sodium propionate promotes the reaction [biochanin A results in increased expression of CYP1B1 mRNA]
CTD PMID:15479032 PMID:28985473 PMID:31621310 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 affects activity
increases activity
increases expression
affects expression
ISO biochanin A affects the activity of CYP27B1 protein
biochanin A analog results in increased activity of CYP27B1 protein; biochanin A results in increased activity of CYP27B1 protein
biochanin A analog results in increased expression of CYP27B1 mRNA; biochanin A results in increased expression of CYP27B1 mRNA
biochanin A affects the expression of CYP27B1 mRNA; biochanin A analog affects the expression of CYP27B1 mRNA
CTD PMID:15795327 PMID:17659868 NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241
JBrowse link
G Dera deoxyribose-phosphate aldolase decreases expression ISO biochanin A results in decreased expression of DERA mRNA CTD PMID:12111696 NCBI chr 4:170,663,646...170,742,469
Ensembl chr 4:170,663,665...170,758,865
JBrowse link
G Eif5 eukaryotic translation initiation factor 5 decreases expression ISO biochanin A results in decreased expression of EIF5 mRNA CTD PMID:12111696
G Enpp5 ectonucleotide pyrophosphatase/phosphodiesterase family member 5 decreases expression ISO biochanin A results in decreased expression of ENPP5 mRNA CTD PMID:12111696 NCBI chr 9:16,910,187...16,917,633
Ensembl chr 9:16,910,831...16,917,480
JBrowse link
G Eps15 epidermal growth factor receptor pathway substrate 15 decreases expression ISO biochanin A results in decreased expression of EPS15 mRNA CTD PMID:12111696 NCBI chr 5:124,045,865...124,146,221
Ensembl chr 5:124,045,926...124,146,221
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
affects binding
ISO biochanin A binds to and results in increased activity of ESR1 protein; biochanin A inhibits the reaction [Estradiol binds to ESR1 protein]
biochanin A binds to ESR1 protein
CTD PMID:9751507 PMID:12598185 PMID:14579009 PMID:16076101 PMID:19913605 More... NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
affects binding
ISO
EXP
biochanin A binds to and results in increased activity of ESR2 protein; biochanin A inhibits the reaction [Estradiol binds to ESR2 protein]
biochanin A binds to ESR2 protein
CTD PMID:9751507 PMID:12224631 PMID:16076101 PMID:16566672 PMID:19913605 More... NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions
affects binding
ISO biochanin A binds to and results in increased activity of ESRRA protein; biochanin A promotes the reaction [ESRRA protein binds to PNRC1 protein]
biochanin A binds to ESRRA protein mutant form
CTD PMID:14638870 NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268
JBrowse link
G Esrrb estrogen-related receptor beta multiple interactions ISO biochanin A binds to and results in increased activity of ESRRB protein; biochanin A promotes the reaction [ESRRB protein binds to PNRC1 protein] CTD PMID:14638870 NCBI chr 6:106,007,662...106,163,136
Ensembl chr 6:106,008,095...106,160,791
JBrowse link
G Esrrg estrogen-related receptor gamma multiple interactions ISO biochanin A promotes the reaction [ESRRG protein binds to PNRC1 protein] CTD PMID:14638870 NCBI chr13:99,167,656...99,788,016
Ensembl chr13:99,564,669...99,783,397
JBrowse link
G Fbl fibrillarin increases expression ISO biochanin A results in increased expression of FBL mRNA CTD PMID:12111696 NCBI chr 1:83,469,832...83,478,932
Ensembl chr 1:83,469,832...83,478,932
JBrowse link
G Folr1 folate receptor alpha decreases expression ISO biochanin A results in decreased expression of FOLR1 mRNA CTD PMID:12111696 NCBI chr 1:156,219,460...156,238,436
Ensembl chr 1:156,219,460...156,230,667
JBrowse link
G Gm2a GM2 ganglioside activator decreases expression ISO biochanin A results in decreased expression of GM2A mRNA CTD PMID:12111696 NCBI chr10:39,219,221...39,231,756
Ensembl chr10:39,219,243...39,231,757
JBrowse link
G Gnai3 G protein subunit alpha i3 decreases expression ISO biochanin A results in decreased expression of GNAI3 mRNA CTD PMID:12111696 NCBI chr 2:195,742,765...195,780,720
Ensembl chr 2:195,742,642...195,780,742
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression ISO biochanin A results in decreased expression of GPX1 mRNA CTD PMID:12111696 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO biochanin A inhibits the reaction [CXCL8 protein results in increased expression of ICAM1 protein] CTD PMID:22387535 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il17a interleukin 17A multiple interactions ISO biochanin A promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA] CTD PMID:25583575 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il4 interleukin 4 increases expression ISO biochanin A results in increased expression of IL4 mRNA; biochanin A results in increased expression of IL4 protein CTD PMID:16169028 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase multiple interactions ISO biochanin A inhibits the reaction [CXCL8 protein results in increased phosphorylation of LCK protein] CTD PMID:22387535 NCBI chr 5:141,888,319...141,916,992
Ensembl chr 5:141,888,326...141,903,794
JBrowse link
G Ldlrad4 low density lipoprotein receptor class A domain containing 4 decreases expression ISO biochanin A results in decreased expression of LDLRAD4 mRNA CTD PMID:12111696 NCBI chr18:61,519,253...61,848,403
Ensembl chr18:61,521,428...61,843,238
JBrowse link
G Lxn latexin increases expression ISO biochanin A results in increased expression of LXN mRNA CTD PMID:12111696 NCBI chr 2:151,727,556...151,733,426
Ensembl chr 2:151,727,102...151,733,460
JBrowse link
G Mmp14 matrix metallopeptidase 14 decreases expression ISO biochanin A results in decreased expression of MMP14 protein CTD PMID:16598420 NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases activity ISO biochanin A results in decreased activity of MMP2 protein CTD PMID:16598420 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases activity ISO biochanin A results in decreased activity of MMP9 protein CTD PMID:16598420 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mt2A metallothionein 2A increases expression ISO biochanin A results in increased expression of MT2A mRNA CTD PMID:10656621 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO biochanin A promotes the reaction [RORC protein binds to NCOA1 protein] CTD PMID:25583575 NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664
JBrowse link
G Ndufa5 NADH:ubiquinone oxidoreductase subunit A5 decreases expression ISO biochanin A results in decreased expression of NDUFA5 mRNA CTD PMID:12111696 NCBI chr 4:52,997,327...53,005,685
Ensembl chr 4:52,995,546...53,005,598
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO [[sodium arsenite results in increased abundance of Arsenic] which co-treated with biochanin A] results in increased expression of NFE2L2 mRNA CTD PMID:33410021 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO biochanin A inhibits the reaction [CXCL8 protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; biochanin A inhibits the reaction [pervanadate results in increased phosphorylation of NFKBIA protein] CTD PMID:22387535 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nono non-POU domain containing, octamer-binding decreases expression ISO biochanin A results in decreased expression of NONO mRNA CTD PMID:12111696 NCBI chr  X:66,554,131...66,571,992
Ensembl chr  X:66,554,098...66,571,952
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO biochanin A inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO biochanin A binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO biochanin A results in increased cleavage of PARP1 protein CTD PMID:12791511 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pfdn5 prefoldin subunit 5 decreases expression ISO biochanin A results in decreased expression of PFDN5 mRNA CTD PMID:12111696 NCBI chr 7:133,451,778...133,456,516
Ensembl chr 7:133,451,453...133,456,516
JBrowse link
G Pgr progesterone receptor affects binding
increases expression
multiple interactions
ISO biochanin A binds to PGR protein
biochanin A results in increased expression of PGR mRNA
biochanin A inhibits the reaction [Progesterone binds to PGR protein]
CTD PMID:14579009 PMID:16076101 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Plaur plasminogen activator, urokinase receptor decreases expression ISO biochanin A results in decreased expression of PLAUR protein CTD PMID:16598420 NCBI chr 1:80,053,441...80,068,384
Ensembl chr 1:80,050,324...80,068,595
JBrowse link
G Pnrc1 proline-rich nuclear receptor coactivator 1 multiple interactions ISO biochanin A promotes the reaction [ESRRA protein binds to PNRC1 protein]; biochanin A promotes the reaction [ESRRB protein binds to PNRC1 protein]; biochanin A promotes the reaction [ESRRG protein binds to PNRC1 protein] CTD PMID:14638870 NCBI chr 5:47,647,070...47,657,832
Ensembl chr 5:47,647,071...47,650,161
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO biochanin A binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO biochanin A inhibits the reaction [CXCL8 protein results in increased expression of PTGS2 protein] CTD PMID:22387535 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rabl6 RAB, member RAS oncogene family-like 6 decreases expression ISO biochanin A results in decreased expression of RABL6 mRNA CTD PMID:12111696 NCBI chr 3:8,402,666...8,428,588
Ensembl chr 3:8,402,672...8,428,611
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO biochanin A results in decreased expression of RELA mRNA CTD PMID:12111696 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rif1 replication timing regulatory factor 1 decreases expression ISO biochanin A results in decreased expression of RIF1 mRNA CTD PMID:12111696 NCBI chr 3:36,554,689...36,607,961
Ensembl chr 3:36,554,697...36,603,617
JBrowse link
G Rorc RAR-related orphan receptor C multiple interactions ISO biochanin A promotes the reaction [RORC protein binds to NCOA1 protein] CTD PMID:25583575 NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907
JBrowse link
G Rpusd3 RNA pseudouridine synthase D3 decreases expression ISO biochanin A results in decreased expression of RPUSD3 mRNA CTD PMID:12111696 NCBI chr 4:146,553,230...146,562,794
Ensembl chr 4:146,558,562...146,562,794
JBrowse link
G Sh3gl1 SH3 domain containing GRB2 like 1, endophilin A2 increases expression ISO biochanin A results in increased expression of SH3GL1 mRNA CTD PMID:12111696 NCBI chr 9:842,285...869,753
Ensembl chr 9:842,288...869,716
JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions EXP [biochanin A results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate CTD PMID:17108059 NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611
JBrowse link
G Slc25a3 solute carrier family 25 member 3 decreases expression ISO biochanin A results in decreased expression of SLC25A3 mRNA CTD PMID:12111696 NCBI chr 7:25,611,937...25,619,401 JBrowse link
G Slco1a1 solute carrier organic anion transporter family, member 1a1 decreases activity
multiple interactions
EXP biochanin A results in decreased activity of SLCO1B1 protein
[biochanin A results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan; [biochanin A results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Methotrexate
CTD PMID:32259555 NCBI chr 4:174,877,045...174,950,857
Ensembl chr 4:174,876,593...174,950,873
JBrowse link
G Srsf1 serine and arginine rich splicing factor 1 decreases expression ISO biochanin A results in decreased expression of SRSF1 mRNA CTD PMID:12111696 NCBI chr10:72,838,926...72,859,066
Ensembl chr10:72,839,274...72,845,336
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases expression EXP biochanin A results in increased expression of SULT1A1 mRNA; biochanin A results in increased expression of SULT1A1 protein CTD PMID:20391625 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 increases expression EXP biochanin A results in increased expression of SULT1E1 mRNA; biochanin A results in increased expression of SULT1E1 protein CTD PMID:20391625 NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 increases expression EXP biochanin A results in increased expression of SULT2A1 mRNA; biochanin A results in increased expression of SULT2A1 protein CTD PMID:20391625 NCBI chr 1:75,451,178...75,508,142 JBrowse link
G Susd6 sushi domain containing 6 increases expression ISO biochanin A results in increased expression of SUSD6 mRNA CTD PMID:12111696 NCBI chr 6:100,437,826...100,531,621
Ensembl chr 6:100,437,642...100,531,606
JBrowse link
G Syk spleen associated tyrosine kinase multiple interactions ISO biochanin A inhibits the reaction [CXCL8 protein results in increased phosphorylation of SYK protein] CTD PMID:22387535 NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410
JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO biochanin A binds to and results in increased activity of THRB protein CTD PMID:33049310 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP biochanin A inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:16735947 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf21 TNF receptor superfamily member 21 decreases expression ISO biochanin A results in decreased expression of TNFRSF21 mRNA CTD PMID:12111696 NCBI chr 9:17,879,156...17,954,085
Ensembl chr 9:17,879,156...17,954,085
JBrowse link
G Tubb5 tubulin, beta 5 class I increases expression ISO biochanin A results in increased expression of TUBB mRNA CTD PMID:12111696 NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940
JBrowse link
G Tyr tyrosinase increases expression ISO biochanin A results in increased expression of TYR mRNA CTD PMID:21071833 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
JBrowse link
G Ube2d2 ubiquitin-conjugating enzyme E2D 2 decreases expression ISO biochanin A results in decreased expression of UBE2D2 mRNA CTD PMID:12111696 NCBI chr18:27,364,665...27,405,589
Ensembl chr18:27,364,303...27,406,181
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation
increases expression
ISO UGT1A1 protein results in increased glucuronidation of biochanin A
biochanin A results in increased expression of UGT1A1 mRNA
CTD PMID:14557274 PMID:31621310 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of biochanin A CTD PMID:14557274 NCBI chr 9:88,696,981...88,808,465 JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions
decreases expression
EXP biochanin A inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Fulvestrant inhibits the reaction [biochanin A results in decreased expression of VCAM1 protein] CTD PMID:16223672 PMID:16735947 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Wdr74 WD repeat domain 74 decreases expression ISO biochanin A results in decreased expression of WDR74 mRNA CTD PMID:12111696 NCBI chr 1:205,631,769...205,636,563
Ensembl chr 1:205,631,824...205,636,563
JBrowse link
G Wwc2 WW and C2 domain containing 2 decreases expression ISO biochanin A results in decreased expression of WWC2 mRNA CTD PMID:12111696 NCBI chr16:44,258,372...44,421,815
Ensembl chr16:44,258,372...44,421,812
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      application 19481
        pharmaceutical 19329
          drug 19329
            antineoplastic agent 17317
              biochanin A 84
                2,3-dihydrobiochanin A 0
                biochanin A 7-O-(6-O-malonyl-beta-D-glucoside) 0
                biochanin A 7-O-beta-D-glucoside 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      ketone 16923
                                        cyclic ketone 15391
                                          isoflavones 3750
                                            methoxyisoflavone 239
                                              4'-methoxyisoflavones 136
                                                biochanin A 84
                                                  2,3-dihydrobiochanin A 0
                                                  biochanin A 7-O-(6-O-malonyl-beta-D-glucoside) 0
                                                  biochanin A 7-O-beta-D-glucoside 0
paths to the root