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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:5'-S-methyl-5'-thioadenosine
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Accession:CHEBI:17509 term browser browse the term
Definition:Adenosine with the hydroxy group at C-5' substituted with a methylthio (methylsulfanyl) group.
Synonyms:exact_synonym: 5'-deoxy-5'-(methylsulfanyl)adenosine
 related_synonym: 5'-Deoxy-5'-(methylthio)adenosine;   5-Methylthioadenosine;   9-(5-S-methyl-5-thio-beta-D-ribofuranosyl)-9H-purin-6-amine;   Formula=C11H15N5O3S;   InChI=1S/C11H15N5O3S/c1-20-2-5-7(17)8(18)11(19-5)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1;   InChIKey=WUUGFSXJNOTRMR-IOSLPCCCSA-N;   MTA;   Methylthioadenosine;   S-Methyl-5-thioadenosine;   SMILES=CSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12;   Thiomethyladenosine
 alt_id: CHEBI:12055;   CHEBI:12064;   CHEBI:12771;   CHEBI:14605;   CHEBI:1966;   CHEBI:1986;   CHEBI:20491;   CHEBI:20494;   CHEBI:44181
 xref: Beilstein:42420;   CAS:2457-80-9;   DrugBank:DB02282;   HMDB:HMDB0001173;   KEGG:C00170
 xref_mesh: MESH:C008500
 xref: MetaCyc:5-METHYLTHIOADENOSINE;   PMID:22735334;   Reaxys:42420


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5'-S-methyl-5'-thioadenosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col1a1 collagen type I alpha 1 chain decreases expression ISO 5'-methylthioadenosine results in decreased expression of COL1A1 mRNA CTD PMID:15983038 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col1a2 collagen type I alpha 2 chain decreases expression ISO 5'-methylthioadenosine results in decreased expression of COL1A2 mRNA CTD PMID:15983038 NCBI chr 4:31,534,225...31,569,152
Ensembl chr 4:31,534,225...31,569,151
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 increases abundance
multiple interactions
ISO IDH2 protein mutant form results in increased abundance of 5'-methylthioadenosine
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of 5'-methylthioadenosine]
CTD PMID:27469509 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705
JBrowse link
G Ifng interferon gamma multiple interactions ISO 5'-methylthioadenosine inhibits the reaction [fumonisin B1 results in increased expression of IFNG mRNA] CTD PMID:17080400 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 5'-methylthioadenosine inhibits the reaction [fumonisin B1 results in increased expression of IL1B mRNA] CTD PMID:17080400 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 multiple interactions ISO 5'-methylthioadenosine inhibits the reaction [fumonisin B1 results in increased expression of IL2 mRNA] CTD PMID:17080400 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il6 interleukin 6 multiple interactions ISO 5'-methylthioadenosine inhibits the reaction [fumonisin B1 results in increased expression of IL6 mRNA] CTD PMID:17080400 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G LOC103694381 lymphotoxin-beta multiple interactions ISO 5'-methylthioadenosine inhibits the reaction [fumonisin B1 results in increased expression of LTB mRNA] CTD PMID:17080400 NCBI chr20:4,861,343...4,863,513
Ensembl chr20:4,861,335...4,863,198
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19792
    role 19738
      biological role 19737
        pharmacological role 18819
          analgesic 13074
            adenosine 321
              5'-S-methyl-5'-thioadenosine 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19792
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19571
                        carbon atom 19560
                          organic molecular entity 19560
                            heteroorganic entity 19165
                              organochalcogen compound 18873
                                organooxygen compound 18795
                                  carbohydrates and carbohydrate derivatives 12193
                                    carbohydrate 12193
                                      carbohydrate derivative 11814
                                        glycosyl compound 10854
                                          N-glycosyl compound 5331
                                            nucleoside 5190
                                              ribonucleoside 691
                                                purine ribonucleoside 585
                                                  purines D-ribonucleoside 328
                                                    adenosine 321
                                                      thioadenosine 8
                                                        5'-S-methyl-5'-thioadenosine 8
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.