CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: glycolic acid
Accession: CHEBI:17497
browse the term
Definition: A 2-hydroxy monocarboxylic acid that is acetic acid where the methyl group has been hydroxylated.
Synonyms: related_synonym: 2-Hydroxyacetic acid; 2-Hydroxyethanoic acid; Formula=C2H4O3; Glycollic acid; HOCH2COOH; Hydroxyacetic acid; Hydroxyethanoic acid; InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5); InChIKey=AEMRFAOFKBGASW-UHFFFAOYSA-N; SMILES=OCC(O)=O; alpha-hydroxyacetic acid
alt_id: CHEBI:24390; CHEBI:42865; CHEBI:5475
xref: CAS:79-14-1; Drug_Central:4645; HMDB:HMDB0000115; KEGG:C00160; KNApSAcK:C00007461; LIPID_MAPS_instance:LMFA01050148
xref_mesh: MESH:C031149
xref: MetaCyc:GLYCOLLATE; PDBeChem:GOA; PMID:14585457; PMID:15662707; PMID:15716481; PMID:15716482; PMID:18498500; PMID:19025792; PMID:21950544; PMID:22044748; PMID:22128110; PMID:22360337; PMID:22421647; Reaxys:1209322; Wikipedia:Glycolic_acid
cyclic_relationship: is_conjugate_acid_of CHEBI:29805
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Fgf8
fibroblast growth factor 8
decreases expression
ISO
glycolic acid results in decreased expression of FGF8 mRNA
CTD
PMID:31711903
NCBI chr 1:244,584,477...244,590,359
Ensembl chr 1:244,584,652...244,590,359
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Il1b
interleukin 1 beta
increases expression
ISO
glycolic acid results in increased expression of IL1B protein
CTD
PMID:29953848
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Pax3
paired box 3
decreases expression
ISO
glycolic acid results in decreased expression of PAX3 mRNA
CTD
PMID:31711903
NCBI chr 9:79,567,455...79,664,042
Ensembl chr 9:79,568,634...79,664,042
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Uncx
UNC homeobox
decreases expression
ISO
glycolic acid results in decreased expression of UNCX mRNA
CTD
PMID:31711903
NCBI chr12:15,092,779...15,097,300
Ensembl chr12:15,092,784...15,097,300
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Abca7
ATP binding cassette subfamily A member 7
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ABCA7 mRNA
CTD
PMID:18579281
NCBI chr 7:9,691,452...9,711,466
Ensembl chr 7:9,691,449...9,711,425
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Abcb4
ATP binding cassette subfamily B member 4
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ABCB4 mRNA
CTD
PMID:9210621
NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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Abcc2
ATP binding cassette subfamily C member 2
increases expression multiple interactions
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ABCC2 mRNA; 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ABCC2 protein Alpha-Amanitin inhibits the reaction [2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ABCC2 mRNA]
CTD
PMID:10377250 PMID:16426233
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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Acap3
ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of ACAP3 mRNA
CTD
PMID:18579281
NCBI chr 5:166,500,781...166,515,477
Ensembl chr 5:166,500,781...166,515,481
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Acer2
alkaline ceramidase 2
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of ACER2 mRNA
CTD
PMID:18579281
NCBI chr 5:101,391,830...101,442,615
Ensembl chr 5:101,391,885...101,442,614
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Adgrb2
adhesion G protein-coupled receptor B2
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ADGRB2 mRNA
CTD
PMID:18579281
NCBI chr 5:142,299,190...142,362,540
Ensembl chr 5:142,331,329...142,362,540
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Adh4
alcohol dehydrogenase 4 (class II), pi polypeptide
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ADH4 mRNA
CTD
PMID:18579281
NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591
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Alpi
alkaline phosphatase, intestinal
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of ALPI mRNA
CTD
PMID:18579281
NCBI chr 9:87,773,411...87,776,877
Ensembl chr 9:87,773,411...87,776,877
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Ar
androgen receptor
affects binding
EXP
2,4,5-Trichlorophenoxyacetic Acid binds to AR protein
CTD
PMID:14565775
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Arhgap32
Rho GTPase activating protein 32
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ARHGAP32 mRNA
CTD
PMID:18579281
NCBI chr 8:30,421,269...30,681,653
Ensembl chr 8:30,421,515...30,678,454
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Arsg
arylsulfatase G
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ARSG mRNA
CTD
PMID:18579281
NCBI chr10:94,412,261...94,551,224
Ensembl chr10:94,447,399...94,542,941
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Basp1
brain abundant, membrane attached signal protein 1
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of BASP1 mRNA
CTD
PMID:18579281
NCBI chr 2:75,816,130...75,863,801
Ensembl chr 2:75,816,122...75,864,043
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C1qtnf4
C1q and TNF related 4
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of C1QTNF4 mRNA
CTD
PMID:18579281
NCBI chr 3:76,854,368...76,872,991
Ensembl chr 3:76,857,735...76,874,139
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Cacnb3
calcium voltage-gated channel auxiliary subunit beta 3
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of CACNB3 mRNA
CTD
PMID:18579281
NCBI chr 7:129,784,799...129,797,074
Ensembl chr 7:129,783,674...129,797,074
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Camk1d
calcium/calmodulin-dependent protein kinase ID
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of CAMK1D mRNA
CTD
PMID:18579281
NCBI chr17:72,581,899...72,982,704
Ensembl chr17:72,581,979...72,980,556
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Capn6
calpain 6
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of CAPN6 mRNA
CTD
PMID:18579281
NCBI chr X:107,380,774...107,405,489
Ensembl chr X:107,380,774...107,405,489
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Cdh1
cadherin 1
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of CDH1 mRNA
CTD
PMID:18579281
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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Cirbp
cold inducible RNA binding protein
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of CIRBP mRNA
CTD
PMID:18579281
NCBI chr 7:9,533,857...9,538,899
Ensembl chr 7:9,424,178...9,538,818
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Ckm
creatine kinase, M-type
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of CKM mRNA
CTD
PMID:18579281
NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720
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Col15a1
collagen type XV alpha 1 chain
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of COL15A1 mRNA
CTD
PMID:18579281
NCBI chr 5:61,501,963...61,607,591
Ensembl chr 5:61,501,963...61,607,591
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Cyp7b1
cytochrome P450 family 7 subfamily B member 1
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of CYP7B1 mRNA
CTD
PMID:18579281
NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698
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Ddc
dopa decarboxylase
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of DDC mRNA
CTD
PMID:18579281
NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208
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Eepd1
endonuclease/exonuclease/phosphatase family domain containing 1
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of EEPD1 mRNA
CTD
PMID:18579281
NCBI chr 8:23,957,258...24,064,343
Ensembl chr 8:23,957,255...24,064,340
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Ephx1
epoxide hydrolase 1
increases activity
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased activity of EPHX1 protein
CTD
PMID:3032197
NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235
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Ephx2
epoxide hydrolase 2
multiple interactions
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of and results in increased activity of EPHX2 protein
CTD
PMID:3032197
NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
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Esr1
estrogen receptor 1
multiple interactions
ISO
2,4,5-Trichlorophenoxyacetic Acid binds to and results in decreased activity of ESR1 protein
CTD
PMID:16626760
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Far1
fatty acyl CoA reductase 1
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of FAR1 mRNA
CTD
PMID:18579281
NCBI chr 1:167,644,622...167,705,868
Ensembl chr 1:167,644,677...167,705,730
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Fkbp5
FKBP prolyl isomerase 5
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of FKBP5 mRNA
CTD
PMID:18579281
NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674
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Fmo2
flavin containing dimethylaniline monoxygenase 2
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of FMO2 mRNA
CTD
PMID:18579281
NCBI chr13:75,221,149...75,244,377
Ensembl chr13:75,224,402...75,244,308
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G0s2
G0/G1switch 2
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of G0S2 mRNA
CTD
PMID:18579281
NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451
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Gbf1
golgi brefeldin A resistant guanine nucleotide exchange factor 1
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of GBF1 mRNA
CTD
PMID:18579281
NCBI chr 1:245,018,535...245,147,052
Ensembl chr 1:245,018,568...245,147,042
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Gbp6
guanylate binding protein family member 6
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of GBP9 mRNA
CTD
PMID:18579281
NCBI chr14:4,730,286...4,756,508
Ensembl chr14:4,730,453...4,839,062
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Gclc
glutamate-cysteine ligase, catalytic subunit
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of GCLC mRNA 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of GCLC; 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of GCLC mRNA
CTD
PMID:10377250 PMID:16426233
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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Gde1
glycerophosphodiester phosphodiesterase 1
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of GDE1 mRNA
CTD
PMID:18579281
NCBI chr 1:173,016,984...173,032,396
Ensembl chr 1:172,954,394...173,032,429
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Gfra1
GDNF family receptor alpha 1
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of GFRA1 mRNA
CTD
PMID:18579281
NCBI chr 1:257,315,682...257,552,004
Ensembl chr 1:257,321,742...257,551,473
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Git2
GIT ArfGAP 2
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of GIT2 mRNA
CTD
PMID:18579281
NCBI chr12:41,829,717...41,872,621
Ensembl chr12:41,829,730...41,871,097
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Gmppb
GDP-mannose pyrophosphorylase B
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of GMPPB mRNA
CTD
PMID:18579281
NCBI chr 8:108,737,429...108,767,286
Ensembl chr 8:108,693,060...108,767,286
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Got1
glutamic-oxaloacetic transaminase 1
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of GOT1 mRNA
CTD
PMID:18579281
NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
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Gpm6a
glycoprotein m6a
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of GPM6A mRNA
CTD
PMID:18579281
NCBI chr16:36,641,282...36,973,477
Ensembl chr16:36,641,284...36,973,475
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Gpr12
G protein-coupled receptor 12
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of GPR12 mRNA
CTD
PMID:18579281
NCBI chr12:8,522,709...8,525,875
Ensembl chr12:8,522,953...8,527,973
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Gpr85
G protein-coupled receptor 85
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of GPR85 mRNA
CTD
PMID:18579281
NCBI chr 4:42,100,138...42,109,584
Ensembl chr 4:42,102,941...42,109,566
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Hapln1
hyaluronan and proteoglycan link protein 1
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of HAPLN1 mRNA
CTD
PMID:18579281
NCBI chr 2:20,631,640...20,696,388
Ensembl chr 2:20,631,640...20,693,777
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Hmox1
heme oxygenase 1
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of HMOX1 mRNA
CTD
PMID:18579281
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Hspa8
heat shock protein family A (Hsp70) member 8
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of HSPA8 mRNA
CTD
PMID:18579281
NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
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Hspb1
heat shock protein family B (small) member 1
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of HSPB1 mRNA
CTD
PMID:18579281
NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
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Hsph1
heat shock protein family H (Hsp110) member 1
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of HSPH1 mRNA
CTD
PMID:18579281
NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224
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Ido2
indoleamine 2,3-dioxygenase 2
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of IDO2 mRNA
CTD
PMID:18579281
NCBI chr16:67,459,158...67,498,052
Ensembl chr16:67,459,190...67,496,324
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Ihh
Indian hedgehog signaling molecule
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of IHH mRNA
CTD
PMID:18579281
NCBI chr 9:76,504,315...76,510,532
Ensembl chr 9:76,504,315...76,510,532
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Ikbke
inhibitor of nuclear factor kappa B kinase subunit epsilon
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of IKBKE mRNA
CTD
PMID:18579281
NCBI chr13:42,712,154...42,738,470
Ensembl chr13:42,712,159...42,737,143
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Il1r1
interleukin 1 receptor type 1
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of IL1R1 mRNA
CTD
PMID:18579281
NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937
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Insc
INSC, spindle orientation adaptor protein
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of INSC mRNA
CTD
PMID:18579281
NCBI chr 1:168,993,032...169,100,438
Ensembl chr 1:168,993,032...169,100,433
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Klf5
Kruppel-like factor 5
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of KLF5 mRNA
CTD
PMID:18579281
NCBI chr15:76,060,320...76,079,445
Ensembl chr15:76,064,258...76,079,445
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Limch1
LIM and calponin homology domains 1
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of LIMCH1 mRNA
CTD
PMID:18579281
NCBI chr14:41,112,579...41,425,185
Ensembl chr14:41,114,803...41,425,191
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Lmcd1
LIM and cysteine-rich domains 1
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of LMCD1 mRNA
CTD
PMID:18579281
NCBI chr 4:145,393,153...145,452,049
Ensembl chr 4:145,393,145...145,452,046
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Lpar4
lysophosphatidic acid receptor 4
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of LPAR4 mRNA
CTD
PMID:18579281
NCBI chr X:72,033,486...72,046,978
Ensembl chr X:72,033,486...72,046,977
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Lpin1
lipin 1
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of LPIN1 mRNA
CTD
PMID:18579281
NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097
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Lrtm1
leucine-rich repeats and transmembrane domains 1
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of LRTM1 mRNA
CTD
PMID:18579281
NCBI chr16:4,210,343...4,217,843
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Matk
megakaryocyte-associated tyrosine kinase
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of MATK mRNA
CTD
PMID:18579281
NCBI chr 7:8,456,990...8,465,947
Ensembl chr 7:8,456,998...8,462,022
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Mpdz
multiple PDZ domain crumbs cell polarity complex component
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of MPDZ mRNA
CTD
PMID:18579281
NCBI chr 5:95,766,112...95,920,531
Ensembl chr 5:95,766,118...95,920,499
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Mt1
metallothionein 1
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of MT1 mRNA
CTD
PMID:18579281
NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
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Mt4
metallothionein 4
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of MT4 mRNA
CTD
PMID:18579281
NCBI chr19:10,863,813...10,865,909
Ensembl chr19:10,863,813...10,865,909
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Mvd
mevalonate diphosphate decarboxylase
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of MVD mRNA
CTD
PMID:18579281
NCBI chr19:50,496,366...50,506,389
Ensembl chr19:50,496,367...50,507,971
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Mybph
myosin binding protein H
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of MYBPH mRNA
CTD
PMID:18579281
NCBI chr13:45,653,156...45,660,893
Ensembl chr13:45,653,234...45,660,893
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Ndrg4
NDRG family member 4
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of NDRG4 mRNA
CTD
PMID:18579281
NCBI chr19:9,351,408...9,387,398
Ensembl chr19:9,351,404...9,386,914
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Nip7
nucleolar pre-rRNA processing protein NIP7
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of NIP7 mRNA
CTD
PMID:18579281
NCBI chr19:34,962,557...34,964,700
Ensembl chr19:34,962,557...34,964,711
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Nrg4
neuregulin 4
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of NRG4 mRNA
CTD
PMID:18579281
NCBI chr 8:55,586,253...55,677,829
Ensembl chr 8:55,592,893...55,677,483
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Ogn
osteoglycin
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of OGN mRNA
CTD
PMID:18579281
NCBI chr17:15,032,069...15,052,626
Ensembl chr17:15,032,069...15,052,739
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Olr346
olfactory receptor 346
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of OLFR1451 mRNA
CTD
PMID:18579281
NCBI chr 1:210,136,841...210,137,767
Ensembl chr 1:210,132,946...210,138,365
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Pdzd3
PDZ domain containing 3
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PDZD3 mRNA
CTD
PMID:18579281
NCBI chr 8:44,584,390...44,588,838
Ensembl chr 8:44,584,390...44,588,860
G
Pfkp
phosphofructokinase, platelet
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PFKP mRNA
CTD
PMID:18579281
NCBI chr17:63,729,743...63,794,021
Ensembl chr17:63,729,780...63,794,018
G
Plin4
perilipin 4
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PLIN4 mRNA
CTD
PMID:18579281
NCBI chr 9:929,168...938,062
Ensembl chr 9:929,176...938,056
G
Por
cytochrome p450 oxidoreductase
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of POR mRNA
CTD
PMID:18579281
NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
G
Ppfibp1
PPFIA binding protein 1
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PPFIBP1 mRNA
CTD
PMID:18579281
NCBI chr 4:179,807,579...179,951,428
Ensembl chr 4:179,808,794...179,951,428
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Ppp1r3a
protein phosphatase 1, regulatory subunit 3A
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PPP1R3A mRNA
CTD
PMID:18579281
NCBI chr 4:42,937,353...42,980,195
Ensembl chr 4:42,939,599...42,980,638
G
Ppp1r3g
protein phosphatase 1, regulatory subunit 3G
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PPP1R3G mRNA
CTD
PMID:18579281
NCBI chr17:28,874,956...28,878,288
Ensembl chr17:28,876,482...28,877,525
G
Prok1
prokineticin 1
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of PROK1 mRNA
CTD
PMID:18579281
NCBI chr 2:194,853,991...194,859,250
Ensembl chr 2:194,853,991...194,859,250
G
Prr9
proline rich 9
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PRR9 mRNA
CTD
PMID:18579281
NCBI chr 2:177,599,483...177,600,849
Ensembl chr 2:177,599,483...177,600,849
G
Ptp4a1
protein tyrosine phosphatase 4A1
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PTP4A1 mRNA
CTD
PMID:18579281
NCBI chr 9:33,214,201...33,245,046
Ensembl chr 9:33,214,208...33,221,964
G
Retreg1
reticulophagy regulator 1
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of RETREG1 mRNA
CTD
PMID:18579281
NCBI chr 2:76,335,609...76,474,817
Ensembl chr 2:76,335,609...76,493,898
G
Rprd1a
regulation of nuclear pre-mRNA domain containing 1A
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of RPRD1A mRNA
CTD
PMID:18579281
NCBI chr18:15,791,418...15,839,338
Ensembl chr18:15,791,418...15,839,338
G
Selenop
selenoprotein P
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of SELENOP mRNA
CTD
PMID:18579281
NCBI chr 2:52,498,123...52,508,409
Ensembl chr 2:52,498,339...52,508,852
G
Sema3c
semaphorin 3C
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of SEMA3C mRNA
CTD
PMID:18579281
NCBI chr 4:17,583,212...17,747,234
Ensembl chr 4:17,583,212...17,746,534
G
Sgk2
serum/glucocorticoid regulated kinase 2
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SGK2 mRNA
CTD
PMID:18579281
NCBI chr 3:151,644,102...151,669,480
Ensembl chr 3:151,644,102...151,669,480
G
Slc24a2
solute carrier family 24 member 2
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SLC24A2 mRNA
CTD
PMID:18579281
NCBI chr 5:101,499,536...101,739,337
Ensembl chr 5:101,502,278...101,739,337
G
Slc25a32
solute carrier family 25 member 32
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of SLC25A32 mRNA
CTD
PMID:18579281
NCBI chr 7:70,142,958...70,160,726
Ensembl chr 7:70,142,964...70,160,770
G
Slc66a1
solute carrier family 66 member 1
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SLC66A1 mRNA
CTD
PMID:18579281
NCBI chr 5:151,537,870...151,552,338
Ensembl chr 5:151,542,376...151,552,259
G
Slc6a15
solute carrier family 6 member 15
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of SLC6A15 mRNA
CTD
PMID:18579281
NCBI chr 7:38,553,055...38,607,239
Ensembl chr 7:38,553,196...38,607,239
G
Snx7
sorting nexin 7
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SNX7 mRNA
CTD
PMID:18579281
NCBI chr 2:205,843,164...205,927,737
Ensembl chr 2:205,842,837...205,927,763
G
Spon2
spondin 2
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SPON2 mRNA
CTD
PMID:18579281
NCBI chr14:77,505,695...77,518,001
Ensembl chr14:77,511,901...77,517,996
G
Srebf1
sterol regulatory element binding transcription factor 1
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SREBF1 mRNA
CTD
PMID:18579281
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
G
Svil
supervillin
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SVIL mRNA
CTD
PMID:18579281
NCBI chr17:52,648,502...52,844,114
Ensembl chr17:52,648,502...52,793,404
G
Tacc2
transforming, acidic coiled-coil containing protein 2
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of TACC2 mRNA
CTD
PMID:18579281
NCBI chr 1:185,139,223...185,327,881
Ensembl chr 1:185,116,111...185,327,881
G
Tbc1d8
TBC1 domain family, member 8
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of TBC1D8 mRNA
CTD
PMID:18579281
NCBI chr 9:41,651,394...41,761,432
Ensembl chr 9:41,651,395...41,761,409
G
Tcea2
transcription elongation factor A2
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of TCEA2 mRNA
CTD
PMID:18579281
NCBI chr 3:168,796,244...168,804,125
Ensembl chr 3:168,796,331...168,804,116
G
Thra
thyroid hormone receptor alpha
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of THRA mRNA
CTD
PMID:18579281
NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
G
Thrb
thyroid hormone receptor beta
affects binding
ISO
2,4,5-Trichlorophenoxyacetic Acid binds to THRB protein
CTD
PMID:27410513
NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
G
Tom1l2
target of myb1 like 2 membrane trafficking protein
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of TOM1L2 mRNA
CTD
PMID:18579281
NCBI chr10:45,036,034...45,158,168
Ensembl chr10:45,036,035...45,158,032
G
Trib3
tribbles pseudokinase 3
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of TRIB3 mRNA
CTD
PMID:18579281
NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497
G
Tril
TLR4 interactor with leucine-rich repeats
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of TRIL mRNA
CTD
PMID:18579281
NCBI chr 4:82,922,327...82,927,172
Ensembl chr 4:82,922,328...82,927,172
G
Tsc22d1
TSC22 domain family, member 1
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of TSC22D1 mRNA
CTD
PMID:18579281
NCBI chr15:51,750,489...51,850,958
Ensembl chr15:51,749,510...51,850,958
G
Ugt2a3
UDP glucuronosyltransferase family 2 member A3
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of UGT2A3 mRNA
CTD
PMID:18579281
NCBI chr14:20,572,825...20,590,295
Ensembl chr14:20,572,808...20,590,729
G
Usp2
ubiquitin specific peptidase 2
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of USP2 mRNA
CTD
PMID:18579281
NCBI chr 8:44,411,457...44,439,668
Ensembl chr 8:44,411,607...44,438,331
G
Vcam1
vascular cell adhesion molecule 1
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of VCAM1 mRNA
CTD
PMID:18579281
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
G
Veph1
ventricular zone expressed PH domain-containing 1
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of VEPH1 mRNA
CTD
PMID:18579281
NCBI chr 2:150,291,379...150,537,491
Ensembl chr 2:150,296,573...150,537,266
G
Wars2
tryptophanyl tRNA synthetase 2 (mitochondrial)
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of WARS2 mRNA
CTD
PMID:18579281
NCBI chr 2:186,459,744...186,543,581
Ensembl chr 2:186,459,444...186,543,571
G
Clcnka
chloride voltage-gated channel Ka
decreases activity
EXP
2-Methyl-4-chlorophenoxyacetic Acid analog results in decreased activity of CLCNKA protein
CTD
PMID:15167890
NCBI chr 5:153,691,208...153,706,295
Ensembl chr 5:153,691,209...153,706,148
G
Clcnkb
chloride voltage-gated channel Kb
decreases activity
EXP
2-Methyl-4-chlorophenoxyacetic Acid analog results in decreased activity of CLCNKB protein
CTD
PMID:15167890
NCBI chr 5:153,710,086...153,733,162
Ensembl chr 5:153,710,094...153,732,153
G
Slc1a2
solute carrier family 1 member 2
affects expression
EXP
2-Methyl-4-chlorophenoxyacetic Acid affects the expression of SLC1A2 protein
CTD
PMID:16019039
NCBI chr 3:89,005,129...89,126,498
Ensembl chr 3:89,005,129...89,126,498
G
Tnf
tumor necrosis factor
increases expression
ISO
2-Methyl-4-chlorophenoxyacetic Acid results in increased expression of TNF protein
CTD
PMID:10883730
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Abcb4
ATP binding cassette subfamily B member 4
increases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in increased expression of ABCB4 mRNA
CTD
PMID:9210621
NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
G
Alb
albumin
affects binding
ISO
2,4-Dichlorophenoxyacetic Acid binds to ALB protein
CTD
PMID:9877224 PMID:11451446
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
G
Apaf1
apoptotic peptidase activating factor 1
multiple interactions decreases expression
ISO
[Lipopolysaccharides co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of APAF1 mRNA; [Lipopolysaccharides co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of APAF1 protein 2,4-Dichlorophenoxyacetic Acid results in decreased expression of APAF1 mRNA; 2,4-Dichlorophenoxyacetic Acid results in decreased expression of APAF1 protein
CTD
PMID:33865415
NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
G
Ar
androgen receptor
multiple interactions
ISO
2,4-Dichlorophenoxyacetic Acid inhibits the reaction [Androgens binds to AR protein]; 2,4-Dichlorophenoxyacetic Acid promotes the reaction [Dihydrotestosterone results in increased localization of and results in increased activity of AR protein]
CTD
PMID:16107550
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
G
Axin2
axin 2
multiple interactions increases expression
ISO
[Lipopolysaccharides co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of AXIN2 mRNA 2,4-Dichlorophenoxyacetic Acid results in increased expression of AXIN2 mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of AXIN2 protein
CTD
PMID:34463001
NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231
G
Becn1
beclin 1
multiple interactions decreases expression
EXP
lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in decreased expression of BECN1 protein]
CTD
PMID:34464015
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
G
Casp1
caspase 1
decreases cleavage multiple interactions
EXP
2,4-Dichlorophenoxyacetic Acid results in decreased cleavage of CASP1 protein lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased cleavage of CASP1 protein]
CTD
PMID:34464015
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
G
Ccdc120
coiled-coil domain containing 120
decreases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in decreased expression of CCDC120 mRNA
CTD
PMID:15878651
NCBI chr X:14,753,594...14,772,745
Ensembl chr X:14,753,696...14,772,743
G
Ccl11
C-C motif chemokine ligand 11
increases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in increased expression of CCL11 protein
CTD
PMID:19467290
NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926
G
Ccl2
C-C motif chemokine ligand 2
increases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in increased expression of CCL2 protein
CTD
PMID:19467290
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
G
Ccl4
C-C motif chemokine ligand 4
increases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in increased expression of CCL4 protein
CTD
PMID:19467290
NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
G
Cdk6
cyclin-dependent kinase 6
increases expression multiple interactions
ISO
2,4-Dichlorophenoxyacetic Acid results in increased expression of CDK6 mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of CDK6 protein [Lipopolysaccharides co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of CDK6 mRNA; [Lipopolysaccharides co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of CDK6 protein
CTD
PMID:33865415
NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
G
Cldn1
claudin 1
decreases expression
EXP
2,4-Dichlorophenoxyacetic Acid results in decreased expression of CLDN1 mRNA; 2,4-Dichlorophenoxyacetic Acid results in decreased expression of CLDN1 protein
CTD
PMID:28699141
NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724
G
Clk1
CDC-like kinase 1
decreases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in decreased expression of CLK1 mRNA
CTD
PMID:15878651
NCBI chr 9:59,947,774...59,959,002
Ensembl chr 9:59,947,764...59,957,000
G
Cnp
2',3'-cyclic nucleotide 3' phosphodiesterase
decreases expression
EXP
2,4-Dichlorophenoxyacetic Acid results in decreased expression of CNP protein
CTD
PMID:18460445
NCBI chr10:85,511,164...85,517,723
Ensembl chr10:85,511,160...85,517,720
G
Crat
carnitine O-acetyltransferase
increases activity
ISO
2,4-Dichlorophenoxyacetic Acid results in increased activity of CRAT protein
CTD
PMID:1755024
NCBI chr 3:13,675,684...13,689,282
Ensembl chr 3:13,675,684...13,689,255
G
Creb1
cAMP responsive element binding protein 1
increases expression multiple interactions
ISO
2,4-Dichlorophenoxyacetic Acid results in increased expression of CREB1 mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of CREB1 protein PPARB protein affects the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of CREB1 mRNA]
CTD
PMID:29633193
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
G
Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
affects expression
ISO
2,4-Dichlorophenoxyacetic Acid affects the expression of CYP17A1 mRNA
CTD
PMID:26838045
NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression
EXP
2,4-Dichlorophenoxyacetic Acid results in increased expression of CYP1A1 mRNA
CTD
PMID:10910964
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases expression
EXP
2,4-Dichlorophenoxyacetic Acid results in increased expression of CYP1A2 mRNA
CTD
PMID:10910964
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
G
Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
increases expression
EXP
2,4-Dichlorophenoxyacetic Acid results in increased expression of CYP1B1 mRNA
CTD
PMID:10910964
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
G
Dbh
dopamine beta-hydroxylase
decreases expression
EXP
2,4-Dichlorophenoxyacetic Acid results in decreased expression of DBH protein
CTD
PMID:16931444
NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248
G
Dclre1c
DNA cross-link repair 1C
increases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in increased expression of DCLRE1C mRNA
CTD
PMID:15878651
NCBI chr17:74,775,828...74,810,089
Ensembl chr17:74,776,935...74,809,186
G
Ddb2
damage specific DNA binding protein 2
increases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in increased expression of DDB2 mRNA
CTD
PMID:15878651
NCBI chr 3:77,185,114...77,207,650
Ensembl chr 3:77,185,109...77,207,631
G
Ddit3
DNA-damage inducible transcript 3
increases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in increased expression of DDIT3 mRNA
CTD
PMID:34626751
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
G
Ephx1
epoxide hydrolase 1
increases activity
ISO
2,4-Dichlorophenoxyacetic Acid results in increased activity of EPHX1 protein
CTD
PMID:3032197
NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235
G
Ephx2
epoxide hydrolase 2
increases activity
ISO
2,4-Dichlorophenoxyacetic Acid results in increased activity of EPHX2 protein
CTD
PMID:1755024 PMID:3032197
NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
G
Foxo1
forkhead box O1
multiple interactions increases expression
ISO
PPARB protein affects the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of FOXO1 mRNA] 2,4-Dichlorophenoxyacetic Acid results in increased expression of FOXO1 mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of FOXO1 protein
CTD
PMID:29633193
NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
G
Fth1
ferritin heavy chain 1
increases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in increased expression of FTH1 mRNA
CTD
PMID:15878651
NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
G
Ftl1
ferritin light chain 1
increases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in increased expression of FTL mRNA
CTD
PMID:15878651
NCBI chr 1:95,936,390...95,938,234
Ensembl chr 1:95,936,387...95,939,725
G
Gfap
glial fibrillary acidic protein
increases expression
EXP
2,4-Dichlorophenoxyacetic Acid results in increased expression of GFAP mRNA
CTD
PMID:22954530
NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
G
Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
decreases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in decreased expression of HMGCR
CTD
PMID:26838045
NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
G
Hmgcs1
3-hydroxy-3-methylglutaryl-CoA synthase 1
decreases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in decreased expression of HMGCS1
CTD
PMID:26838045
NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
G
Ifng
interferon gamma
increases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in increased expression of IFNG
CTD
PMID:20728597
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
G
Il18
interleukin 18
increases expression multiple interactions
EXP
2,4-Dichlorophenoxyacetic Acid results in increased expression of IL18 mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of IL18 protein lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of IL18 mRNA]; lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of IL18 protein]
CTD
PMID:34464015
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
G
Il1b
interleukin 1 beta
increases expression multiple interactions
EXP
2,4-Dichlorophenoxyacetic Acid results in increased expression of IL1B mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of IL1B protein lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of IL1B mRNA]; lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of IL1B protein]
CTD
PMID:34464015
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il1rl1
interleukin 1 receptor-like 1
decreases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in decreased expression of IL1RL1 mRNA
CTD
PMID:15878651
NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256
G
Il2
interleukin 2
increases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in increased expression of IL2
CTD
PMID:20728597
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
G
Il2ra
interleukin 2 receptor subunit alpha
increases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in increased expression of IL2RA
CTD
PMID:20728597
NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697
G
Il4
interleukin 4
increases expression increases secretion
ISO
2,4-Dichlorophenoxyacetic Acid results in increased expression of IL4 protein 2,4-Dichlorophenoxyacetic Acid results in increased secretion of IL4 protein
CTD
PMID:19467290
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
G
Il5
interleukin 5
increases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in increased expression of IL5 protein
CTD
PMID:19467290
NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
G
Il6
interleukin 6
increases expression
ISO EXP
2,4-Dichlorophenoxyacetic Acid results in increased expression of IL6 protein
CTD
PMID:19467290 PMID:34464015
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Itgb1
integrin subunit beta 1
increases expression multiple interactions
ISO
2,4-Dichlorophenoxyacetic Acid results in increased expression of ITGB1 mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of ITGB1 protein [Lipopolysaccharides co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of ITGB1 mRNA; [Lipopolysaccharides co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of ITGB1 protein
CTD
PMID:33865415
NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
G
Ldha
lactate dehydrogenase A
decreases expression
EXP
2,4-Dichlorophenoxyacetic Acid results in decreased expression of LDHA mRNA; 2,4-Dichlorophenoxyacetic Acid results in decreased expression of LDHA protein
CTD
PMID:23538319
NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
G
Map1lc3b
microtubule-associated protein 1 light chain 3 beta
decreases expression multiple interactions
EXP
2,4-Dichlorophenoxyacetic Acid results in decreased expression of MAP1LC3B mRNA lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in decreased expression of MAP1LC3B mRNA]
CTD
PMID:34464015
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
G
Mbp
myelin basic protein
decreases expression
EXP
2,4-Dichlorophenoxyacetic Acid results in decreased expression of MBP protein
CTD
PMID:18460445
NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404
G
Myc
MYC proto-oncogene, bHLH transcription factor
decreases methylation
ISO
2,4-Dichlorophenoxyacetic Acid results in decreased methylation of MYC promoter
CTD
PMID:11857776
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
G
Nfkb1
nuclear factor kappa B subunit 1
multiple interactions increases expression
ISO
[Lipopolysaccharides co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of NFKB1 mRNA; [Lipopolysaccharides co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of NFKB1 protein 2,4-Dichlorophenoxyacetic Acid results in increased expression of NFKB1 mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of NFKB1 protein
CTD
PMID:33865415
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
G
Nlrp3
NLR family, pyrin domain containing 3
increases expression multiple interactions
EXP
2,4-Dichlorophenoxyacetic Acid results in increased expression of NLRP3 mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of NLRP3 protein lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of NLRP3 mRNA]; lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of NLRP3 protein]
CTD
PMID:34464015
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO
2,4-Dichlorophenoxyacetic Acid binds to and results in increased activity of NR1I2 protein
CTD
PMID:21115097
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
G
Ocln
occludin
decreases expression
EXP
2,4-Dichlorophenoxyacetic Acid results in decreased expression of OCLN mRNA
CTD
PMID:28699141
NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
G
Oxt
oxytocin/neurophysin I prepropeptide
decreases secretion
EXP
2,4-Dichlorophenoxyacetic Acid results in decreased secretion of OXT protein
CTD
PMID:20122984
NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490
G
Pcna
proliferating cell nuclear antigen
increases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in increased expression of PCNA mRNA
CTD
PMID:15878651
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
G
Pfkm
phosphofructokinase, muscle
decreases expression
EXP
2,4-Dichlorophenoxyacetic Acid results in decreased expression of PFKM mRNA; 2,4-Dichlorophenoxyacetic Acid results in decreased expression of PFKM protein
CTD
PMID:23538319
NCBI chr 7:129,221,679...129,259,192
Ensembl chr 7:129,221,653...129,259,192
G
Ppara
peroxisome proliferator activated receptor alpha
increases response to substance
ISO
PPARA protein results in increased susceptibility to 2,4-Dichlorophenoxyacetic Acid
CTD
PMID:26838045
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
G
Ppard
peroxisome proliferator-activated receptor delta
multiple interactions increases expression
ISO
PPARB protein affects the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of CREB1 mRNA]; PPARB protein affects the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of FOXO1 mRNA] 2,4-Dichlorophenoxyacetic Acid results in increased expression of PPARB mRNA
CTD
PMID:29633193
NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
G
Prl
prolactin
decreases secretion
EXP
2,4-Dichlorophenoxyacetic Acid results in decreased secretion of PRL protein
CTD
PMID:20122984
NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
G
Ptger3
prostaglandin E receptor 3
decreases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in decreased expression of PTGER3 mRNA
CTD
PMID:15878651
NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434
G
Pycard
PYD and CARD domain containing
increases expression multiple interactions
EXP
2,4-Dichlorophenoxyacetic Acid results in increased expression of PYCARD protein lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of PYCARD protein]
CTD
PMID:34464015
NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
G
Slc16a3
solute carrier family 16 member 3
decreases expression increases expression
EXP
2,4-Dichlorophenoxyacetic Acid results in decreased expression of SLC16A3 mRNA 2,4-Dichlorophenoxyacetic Acid results in increased expression of SLC16A3 mRNA
CTD
PMID:23538319
NCBI chr10:106,212,679...106,222,564
Ensembl chr10:106,212,778...106,222,562
G
Slc22a12
solute carrier family 22 member 12
multiple interactions
ISO
Potassium promotes the reaction [SLC22A12 protein results in increased uptake of 2,4-Dichlorophenoxyacetic Acid]
CTD
PMID:15284287
NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555
G
Slc22a20
solute carrier family 22 member 20
multiple interactions
ISO
2,4-Dichlorophenoxyacetic Acid inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate]
CTD
PMID:16478971
NCBI chr 1:203,257,374...203,273,848
Ensembl chr 1:203,257,374...203,273,822
G
Slc22a6
solute carrier family 22 member 6
increases uptake multiple interactions
EXP ISO
SLC22A6 protein results in increased uptake of 2,4-Dichlorophenoxyacetic Acid p-Aminohippuric Acid inhibits the reaction [SLC22A6 protein results in increased uptake of 2,4-Dichlorophenoxyacetic Acid]
CTD
PMID:16857889 PMID:17255469
NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
G
Slc2a3
solute carrier family 2 member 3
decreases expression increases expression
EXP
2,4-Dichlorophenoxyacetic Acid results in decreased expression of SLC2A3 mRNA; 2,4-Dichlorophenoxyacetic Acid results in decreased expression of SLC2A3 protein 2,4-Dichlorophenoxyacetic Acid results in increased expression of SLC2A3 mRNA
CTD
PMID:23538319
NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472
G
Sqstm1
sequestosome 1
multiple interactions increases expression
EXP
lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of SQSTM1 mRNA]; lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of SQSTM1 protein] 2,4-Dichlorophenoxyacetic Acid results in increased expression of SQSTM1 mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of SQSTM1 protein
CTD
PMID:34464015
NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
G
Srxn1
sulfiredoxin 1
increases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in increased expression of SRXN1 mRNA
CTD
PMID:34626751
NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
G
Th
tyrosine hydroxylase
increases expression
EXP
2,4-Dichlorophenoxyacetic Acid results in increased expression of TH protein
CTD
PMID:16931444
NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
G
Thrb
thyroid hormone receptor beta
affects binding
ISO
2,4-Dichlorophenoxyacetic Acid binds to THRB protein
CTD
PMID:27410513
NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
G
Tjp1
tight junction protein 1
decreases expression
EXP
2,4-Dichlorophenoxyacetic Acid results in decreased expression of TJP1 mRNA; 2,4-Dichlorophenoxyacetic Acid results in decreased expression of TJP1 protein
CTD
PMID:28699141
NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
G
Tnf
tumor necrosis factor
increases expression multiple interactions
ISO EXP
2,4-Dichlorophenoxyacetic Acid results in increased expression of TNF 2,4-Dichlorophenoxyacetic Acid results in increased expression of TNF protein lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of TNF protein]
CTD
PMID:20728597 PMID:34464015
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Tp53
tumor protein p53
multiple interactions increases expression
ISO
[Lipopolysaccharides co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of TRP53 mRNA; [Lipopolysaccharides co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of TRP53 protein 2,4-Dichlorophenoxyacetic Acid results in increased expression of TRP53 mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of TRP53 protein
CTD
PMID:33865415
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Usp19
ubiquitin specific peptidase 19
increases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in increased expression of USP19 mRNA
CTD
PMID:15878651
NCBI chr 8:109,190,727...109,201,761
Ensembl chr 8:109,190,724...109,201,741
G
Vegfa
vascular endothelial growth factor A
decreases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in decreased expression of VEGFA mRNA
CTD
PMID:15878651
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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