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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:glycolic acid
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Accession:CHEBI:17497 term browser browse the term
Definition:A 2-hydroxy monocarboxylic acid that is acetic acid where the methyl group has been hydroxylated.
Synonyms:related_synonym: 2-Hydroxyacetic acid;   2-Hydroxyethanoic acid;   Formula=C2H4O3;   Glycollic acid;   HOCH2COOH;   Hydroxyacetic acid;   Hydroxyethanoic acid;   InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5);   InChIKey=AEMRFAOFKBGASW-UHFFFAOYSA-N;   SMILES=OCC(O)=O;   alpha-hydroxyacetic acid
 alt_id: CHEBI:24390;   CHEBI:42865;   CHEBI:5475
 xref: CAS:79-14-1;   Drug_Central:4645;   HMDB:HMDB0000115;   KEGG:C00160;   KNApSAcK:C00007461;   LIPID_MAPS_instance:LMFA01050148
 xref_mesh: MESH:C031149
 xref: MetaCyc:GLYCOLLATE;   PDBeChem:GOA;   PMID:14585457;   PMID:15662707;   PMID:15716481;   PMID:15716482;   PMID:18498500;   PMID:19025792;   PMID:21950544;   PMID:22044748;   PMID:22128110;   PMID:22360337;   PMID:22421647;   Reaxys:1209322;   Wikipedia:Glycolic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:29805


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glycolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgf8 fibroblast growth factor 8 decreases expression ISO glycolic acid results in decreased expression of FGF8 mRNA CTD PMID:31711903 NCBI chr 1:244,584,477...244,590,359
Ensembl chr 1:244,584,652...244,590,359 		JBrowse link
G Il1b interleukin 1 beta increases expression ISO glycolic acid results in increased expression of IL1B protein CTD PMID:29953848 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Pax3 paired box 3 decreases expression ISO glycolic acid results in decreased expression of PAX3 mRNA CTD PMID:31711903 NCBI chr 9:79,567,455...79,664,042
Ensembl chr 9:79,568,634...79,664,042 		JBrowse link
G Uncx UNC homeobox decreases expression ISO glycolic acid results in decreased expression of UNCX mRNA CTD PMID:31711903 NCBI chr12:15,092,779...15,097,300
Ensembl chr12:15,092,784...15,097,300 		JBrowse link
(2,4,5-trichlorophenoxy)acetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ABCA7 mRNA CTD PMID:18579281 NCBI chr 7:9,691,452...9,711,466
Ensembl chr 7:9,691,449...9,711,425 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ABCB4 mRNA CTD PMID:9210621 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression
multiple interactions		 ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ABCC2 mRNA; 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ABCC2 protein
Alpha-Amanitin inhibits the reaction [2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ABCC2 mRNA]		 CTD PMID:10377250 PMID:16426233 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Acap3 ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of ACAP3 mRNA CTD PMID:18579281 NCBI chr 5:166,500,781...166,515,477
Ensembl chr 5:166,500,781...166,515,481 		JBrowse link
G Acer2 alkaline ceramidase 2 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of ACER2 mRNA CTD PMID:18579281 NCBI chr 5:101,391,830...101,442,615
Ensembl chr 5:101,391,885...101,442,614 		JBrowse link
G Adgrb2 adhesion G protein-coupled receptor B2 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ADGRB2 mRNA CTD PMID:18579281 NCBI chr 5:142,299,190...142,362,540
Ensembl chr 5:142,331,329...142,362,540 		JBrowse link
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ADH4 mRNA CTD PMID:18579281 NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591 		JBrowse link
G Alpi alkaline phosphatase, intestinal decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of ALPI mRNA CTD PMID:18579281 NCBI chr 9:87,773,411...87,776,877
Ensembl chr 9:87,773,411...87,776,877 		JBrowse link
G Ar androgen receptor affects binding EXP 2,4,5-Trichlorophenoxyacetic Acid binds to AR protein CTD PMID:14565775 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Arhgap32 Rho GTPase activating protein 32 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ARHGAP32 mRNA CTD PMID:18579281 NCBI chr 8:30,421,269...30,681,653
Ensembl chr 8:30,421,515...30,678,454 		JBrowse link
G Arsg arylsulfatase G increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ARSG mRNA CTD PMID:18579281 NCBI chr10:94,412,261...94,551,224
Ensembl chr10:94,447,399...94,542,941 		JBrowse link
G Basp1 brain abundant, membrane attached signal protein 1 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of BASP1 mRNA CTD PMID:18579281 NCBI chr 2:75,816,130...75,863,801
Ensembl chr 2:75,816,122...75,864,043 		JBrowse link
G C1qtnf4 C1q and TNF related 4 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of C1QTNF4 mRNA CTD PMID:18579281 NCBI chr 3:76,854,368...76,872,991
Ensembl chr 3:76,857,735...76,874,139 		JBrowse link
G Cacnb3 calcium voltage-gated channel auxiliary subunit beta 3 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of CACNB3 mRNA CTD PMID:18579281 NCBI chr 7:129,784,799...129,797,074
Ensembl chr 7:129,783,674...129,797,074 		JBrowse link
G Camk1d calcium/calmodulin-dependent protein kinase ID increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of CAMK1D mRNA CTD PMID:18579281 NCBI chr17:72,581,899...72,982,704
Ensembl chr17:72,581,979...72,980,556 		JBrowse link
G Capn6 calpain 6 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of CAPN6 mRNA CTD PMID:18579281 NCBI chr  X:107,380,774...107,405,489
Ensembl chr  X:107,380,774...107,405,489 		JBrowse link
G Cdh1 cadherin 1 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of CDH1 mRNA CTD PMID:18579281 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cirbp cold inducible RNA binding protein increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of CIRBP mRNA CTD PMID:18579281 NCBI chr 7:9,533,857...9,538,899
Ensembl chr 7:9,424,178...9,538,818 		JBrowse link
G Ckm creatine kinase, M-type increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of CKM mRNA CTD PMID:18579281 NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720 		JBrowse link
G Col15a1 collagen type XV alpha 1 chain increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of COL15A1 mRNA CTD PMID:18579281 NCBI chr 5:61,501,963...61,607,591
Ensembl chr 5:61,501,963...61,607,591 		JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of CYP7B1 mRNA CTD PMID:18579281 NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698 		JBrowse link
G Ddc dopa decarboxylase increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of DDC mRNA CTD PMID:18579281 NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208 		JBrowse link
G Eepd1 endonuclease/exonuclease/phosphatase family domain containing 1 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of EEPD1 mRNA CTD PMID:18579281 NCBI chr 8:23,957,258...24,064,343
Ensembl chr 8:23,957,255...24,064,340 		JBrowse link
G Ephx1 epoxide hydrolase 1 increases activity ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased activity of EPHX1 protein CTD PMID:3032197 NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235 		JBrowse link
G Ephx2 epoxide hydrolase 2 multiple interactions ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of and results in increased activity of EPHX2 protein CTD PMID:3032197 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO 2,4,5-Trichlorophenoxyacetic Acid binds to and results in decreased activity of ESR1 protein CTD PMID:16626760 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Far1 fatty acyl CoA reductase 1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of FAR1 mRNA CTD PMID:18579281 NCBI chr 1:167,644,622...167,705,868
Ensembl chr 1:167,644,677...167,705,730 		JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of FKBP5 mRNA CTD PMID:18579281 NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674 		JBrowse link
G Fmo2 flavin containing dimethylaniline monoxygenase 2 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of FMO2 mRNA CTD PMID:18579281 NCBI chr13:75,221,149...75,244,377
Ensembl chr13:75,224,402...75,244,308 		JBrowse link
G G0s2 G0/G1switch 2 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of G0S2 mRNA CTD PMID:18579281 NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451 		JBrowse link
G Gbf1 golgi brefeldin A resistant guanine nucleotide exchange factor 1 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of GBF1 mRNA CTD PMID:18579281 NCBI chr 1:245,018,535...245,147,052
Ensembl chr 1:245,018,568...245,147,042 		JBrowse link
G Gbp6 guanylate binding protein family member 6 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of GBP9 mRNA CTD PMID:18579281 NCBI chr14:4,730,286...4,756,508
Ensembl chr14:4,730,453...4,839,062 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of GCLC mRNA
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of GCLC; 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of GCLC mRNA		 CTD PMID:10377250 PMID:16426233 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gde1 glycerophosphodiester phosphodiesterase 1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of GDE1 mRNA CTD PMID:18579281 NCBI chr 1:173,016,984...173,032,396
Ensembl chr 1:172,954,394...173,032,429 		JBrowse link
G Gfra1 GDNF family receptor alpha 1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of GFRA1 mRNA CTD PMID:18579281 NCBI chr 1:257,315,682...257,552,004
Ensembl chr 1:257,321,742...257,551,473 		JBrowse link
G Git2 GIT ArfGAP 2 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of GIT2 mRNA CTD PMID:18579281 NCBI chr12:41,829,717...41,872,621
Ensembl chr12:41,829,730...41,871,097 		JBrowse link
G Gmppb GDP-mannose pyrophosphorylase B increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of GMPPB mRNA CTD PMID:18579281 NCBI chr 8:108,737,429...108,767,286
Ensembl chr 8:108,693,060...108,767,286 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of GOT1 mRNA CTD PMID:18579281 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633 		JBrowse link
G Gpm6a glycoprotein m6a decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of GPM6A mRNA CTD PMID:18579281 NCBI chr16:36,641,282...36,973,477
Ensembl chr16:36,641,284...36,973,475 		JBrowse link
G Gpr12 G protein-coupled receptor 12 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of GPR12 mRNA CTD PMID:18579281 NCBI chr12:8,522,709...8,525,875
Ensembl chr12:8,522,953...8,527,973 		JBrowse link
G Gpr85 G protein-coupled receptor 85 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of GPR85 mRNA CTD PMID:18579281 NCBI chr 4:42,100,138...42,109,584
Ensembl chr 4:42,102,941...42,109,566 		JBrowse link
G Hapln1 hyaluronan and proteoglycan link protein 1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of HAPLN1 mRNA CTD PMID:18579281 NCBI chr 2:20,631,640...20,696,388
Ensembl chr 2:20,631,640...20,693,777 		JBrowse link
G Hmox1 heme oxygenase 1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of HMOX1 mRNA CTD PMID:18579281 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of HSPA8 mRNA CTD PMID:18579281 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of HSPB1 mRNA CTD PMID:18579281 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743 		JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of HSPH1 mRNA CTD PMID:18579281 NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224 		JBrowse link
G Ido2 indoleamine 2,3-dioxygenase 2 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of IDO2 mRNA CTD PMID:18579281 NCBI chr16:67,459,158...67,498,052
Ensembl chr16:67,459,190...67,496,324 		JBrowse link
G Ihh Indian hedgehog signaling molecule increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of IHH mRNA CTD PMID:18579281 NCBI chr 9:76,504,315...76,510,532
Ensembl chr 9:76,504,315...76,510,532 		JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of IKBKE mRNA CTD PMID:18579281 NCBI chr13:42,712,154...42,738,470
Ensembl chr13:42,712,159...42,737,143 		JBrowse link
G Il1r1 interleukin 1 receptor type 1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of IL1R1 mRNA CTD PMID:18579281 NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937 		JBrowse link
G Insc INSC, spindle orientation adaptor protein increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of INSC mRNA CTD PMID:18579281 NCBI chr 1:168,993,032...169,100,438
Ensembl chr 1:168,993,032...169,100,433 		JBrowse link
G Klf5 Kruppel-like factor 5 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of KLF5 mRNA CTD PMID:18579281 NCBI chr15:76,060,320...76,079,445
Ensembl chr15:76,064,258...76,079,445 		JBrowse link
G Limch1 LIM and calponin homology domains 1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of LIMCH1 mRNA CTD PMID:18579281 NCBI chr14:41,112,579...41,425,185
Ensembl chr14:41,114,803...41,425,191 		JBrowse link
G Lmcd1 LIM and cysteine-rich domains 1 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of LMCD1 mRNA CTD PMID:18579281 NCBI chr 4:145,393,153...145,452,049
Ensembl chr 4:145,393,145...145,452,046 		JBrowse link
G Lpar4 lysophosphatidic acid receptor 4 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of LPAR4 mRNA CTD PMID:18579281 NCBI chr  X:72,033,486...72,046,978
Ensembl chr  X:72,033,486...72,046,977 		JBrowse link
G Lpin1 lipin 1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of LPIN1 mRNA CTD PMID:18579281 NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097 		JBrowse link
G Lrtm1 leucine-rich repeats and transmembrane domains 1 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of LRTM1 mRNA CTD PMID:18579281 NCBI chr16:4,210,343...4,217,843 JBrowse link
G Matk megakaryocyte-associated tyrosine kinase increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of MATK mRNA CTD PMID:18579281 NCBI chr 7:8,456,990...8,465,947
Ensembl chr 7:8,456,998...8,462,022 		JBrowse link
G Mpdz multiple PDZ domain crumbs cell polarity complex component increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of MPDZ mRNA CTD PMID:18579281 NCBI chr 5:95,766,112...95,920,531
Ensembl chr 5:95,766,118...95,920,499 		JBrowse link
G Mt1 metallothionein 1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of MT1 mRNA CTD PMID:18579281 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049 		JBrowse link
G Mt4 metallothionein 4 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of MT4 mRNA CTD PMID:18579281 NCBI chr19:10,863,813...10,865,909
Ensembl chr19:10,863,813...10,865,909 		JBrowse link
G Mvd mevalonate diphosphate decarboxylase increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of MVD mRNA CTD PMID:18579281 NCBI chr19:50,496,366...50,506,389
Ensembl chr19:50,496,367...50,507,971 		JBrowse link
G Mybph myosin binding protein H increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of MYBPH mRNA CTD PMID:18579281 NCBI chr13:45,653,156...45,660,893
Ensembl chr13:45,653,234...45,660,893 		JBrowse link
G Ndrg4 NDRG family member 4 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of NDRG4 mRNA CTD PMID:18579281 NCBI chr19:9,351,408...9,387,398
Ensembl chr19:9,351,404...9,386,914 		JBrowse link
G Nip7 nucleolar pre-rRNA processing protein NIP7 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of NIP7 mRNA CTD PMID:18579281 NCBI chr19:34,962,557...34,964,700
Ensembl chr19:34,962,557...34,964,711 		JBrowse link
G Nrg4 neuregulin 4 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of NRG4 mRNA CTD PMID:18579281 NCBI chr 8:55,586,253...55,677,829
Ensembl chr 8:55,592,893...55,677,483 		JBrowse link
G Ogn osteoglycin decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of OGN mRNA CTD PMID:18579281 NCBI chr17:15,032,069...15,052,626
Ensembl chr17:15,032,069...15,052,739 		JBrowse link
G Olr346 olfactory receptor 346 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of OLFR1451 mRNA CTD PMID:18579281 NCBI chr 1:210,136,841...210,137,767
Ensembl chr 1:210,132,946...210,138,365 		JBrowse link
G Pdzd3 PDZ domain containing 3 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PDZD3 mRNA CTD PMID:18579281 NCBI chr 8:44,584,390...44,588,838
Ensembl chr 8:44,584,390...44,588,860 		JBrowse link
G Pfkp phosphofructokinase, platelet decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PFKP mRNA CTD PMID:18579281 NCBI chr17:63,729,743...63,794,021
Ensembl chr17:63,729,780...63,794,018 		JBrowse link
G Plin4 perilipin 4 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PLIN4 mRNA CTD PMID:18579281 NCBI chr 9:929,168...938,062
Ensembl chr 9:929,176...938,056 		JBrowse link
G Por cytochrome p450 oxidoreductase decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of POR mRNA CTD PMID:18579281 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Ppfibp1 PPFIA binding protein 1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PPFIBP1 mRNA CTD PMID:18579281 NCBI chr 4:179,807,579...179,951,428
Ensembl chr 4:179,808,794...179,951,428 		JBrowse link
G Ppp1r3a protein phosphatase 1, regulatory subunit 3A decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PPP1R3A mRNA CTD PMID:18579281 NCBI chr 4:42,937,353...42,980,195
Ensembl chr 4:42,939,599...42,980,638 		JBrowse link
G Ppp1r3g protein phosphatase 1, regulatory subunit 3G decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PPP1R3G mRNA CTD PMID:18579281 NCBI chr17:28,874,956...28,878,288
Ensembl chr17:28,876,482...28,877,525 		JBrowse link
G Prok1 prokineticin 1 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of PROK1 mRNA CTD PMID:18579281 NCBI chr 2:194,853,991...194,859,250
Ensembl chr 2:194,853,991...194,859,250 		JBrowse link
G Prr9 proline rich 9 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PRR9 mRNA CTD PMID:18579281 NCBI chr 2:177,599,483...177,600,849
Ensembl chr 2:177,599,483...177,600,849 		JBrowse link
G Ptp4a1 protein tyrosine phosphatase 4A1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PTP4A1 mRNA CTD PMID:18579281 NCBI chr 9:33,214,201...33,245,046
Ensembl chr 9:33,214,208...33,221,964 		JBrowse link
G Retreg1 reticulophagy regulator 1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of RETREG1 mRNA CTD PMID:18579281 NCBI chr 2:76,335,609...76,474,817
Ensembl chr 2:76,335,609...76,493,898 		JBrowse link
G Rprd1a regulation of nuclear pre-mRNA domain containing 1A decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of RPRD1A mRNA CTD PMID:18579281 NCBI chr18:15,791,418...15,839,338
Ensembl chr18:15,791,418...15,839,338 		JBrowse link
G Selenop selenoprotein P decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of SELENOP mRNA CTD PMID:18579281 NCBI chr 2:52,498,123...52,508,409
Ensembl chr 2:52,498,339...52,508,852 		JBrowse link
G Sema3c semaphorin 3C decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of SEMA3C mRNA CTD PMID:18579281 NCBI chr 4:17,583,212...17,747,234
Ensembl chr 4:17,583,212...17,746,534 		JBrowse link
G Sgk2 serum/glucocorticoid regulated kinase 2 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SGK2 mRNA CTD PMID:18579281 NCBI chr 3:151,644,102...151,669,480
Ensembl chr 3:151,644,102...151,669,480 		JBrowse link
G Slc24a2 solute carrier family 24 member 2 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SLC24A2 mRNA CTD PMID:18579281 NCBI chr 5:101,499,536...101,739,337
Ensembl chr 5:101,502,278...101,739,337 		JBrowse link
G Slc25a32 solute carrier family 25 member 32 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of SLC25A32 mRNA CTD PMID:18579281 NCBI chr 7:70,142,958...70,160,726
Ensembl chr 7:70,142,964...70,160,770 		JBrowse link
G Slc66a1 solute carrier family 66 member 1 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SLC66A1 mRNA CTD PMID:18579281 NCBI chr 5:151,537,870...151,552,338
Ensembl chr 5:151,542,376...151,552,259 		JBrowse link
G Slc6a15 solute carrier family 6 member 15 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of SLC6A15 mRNA CTD PMID:18579281 NCBI chr 7:38,553,055...38,607,239
Ensembl chr 7:38,553,196...38,607,239 		JBrowse link
G Snx7 sorting nexin 7 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SNX7 mRNA CTD PMID:18579281 NCBI chr 2:205,843,164...205,927,737
Ensembl chr 2:205,842,837...205,927,763 		JBrowse link
G Spon2 spondin 2 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SPON2 mRNA CTD PMID:18579281 NCBI chr14:77,505,695...77,518,001
Ensembl chr14:77,511,901...77,517,996 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SREBF1 mRNA CTD PMID:18579281 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Svil supervillin increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SVIL mRNA CTD PMID:18579281 NCBI chr17:52,648,502...52,844,114
Ensembl chr17:52,648,502...52,793,404 		JBrowse link
G Tacc2 transforming, acidic coiled-coil containing protein 2 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of TACC2 mRNA CTD PMID:18579281 NCBI chr 1:185,139,223...185,327,881
Ensembl chr 1:185,116,111...185,327,881 		JBrowse link
G Tbc1d8 TBC1 domain family, member 8 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of TBC1D8 mRNA CTD PMID:18579281 NCBI chr 9:41,651,394...41,761,432
Ensembl chr 9:41,651,395...41,761,409 		JBrowse link
G Tcea2 transcription elongation factor A2 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of TCEA2 mRNA CTD PMID:18579281 NCBI chr 3:168,796,244...168,804,125
Ensembl chr 3:168,796,331...168,804,116 		JBrowse link
G Thra thyroid hormone receptor alpha increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of THRA mRNA CTD PMID:18579281 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936 		JBrowse link
G Thrb thyroid hormone receptor beta affects binding ISO 2,4,5-Trichlorophenoxyacetic Acid binds to THRB protein CTD PMID:27410513 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
G Tom1l2 target of myb1 like 2 membrane trafficking protein decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of TOM1L2 mRNA CTD PMID:18579281 NCBI chr10:45,036,034...45,158,168
Ensembl chr10:45,036,035...45,158,032 		JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of TRIB3 mRNA CTD PMID:18579281 NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497 		JBrowse link
G Tril TLR4 interactor with leucine-rich repeats decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of TRIL mRNA CTD PMID:18579281 NCBI chr 4:82,922,327...82,927,172
Ensembl chr 4:82,922,328...82,927,172 		JBrowse link
G Tsc22d1 TSC22 domain family, member 1 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of TSC22D1 mRNA CTD PMID:18579281 NCBI chr15:51,750,489...51,850,958
Ensembl chr15:51,749,510...51,850,958 		JBrowse link
G Ugt2a3 UDP glucuronosyltransferase family 2 member A3 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of UGT2A3 mRNA CTD PMID:18579281 NCBI chr14:20,572,825...20,590,295
Ensembl chr14:20,572,808...20,590,729 		JBrowse link
G Usp2 ubiquitin specific peptidase 2 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of USP2 mRNA CTD PMID:18579281 NCBI chr 8:44,411,457...44,439,668
Ensembl chr 8:44,411,607...44,438,331 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of VCAM1 mRNA CTD PMID:18579281 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Veph1 ventricular zone expressed PH domain-containing 1 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of VEPH1 mRNA CTD PMID:18579281 NCBI chr 2:150,291,379...150,537,491
Ensembl chr 2:150,296,573...150,537,266 		JBrowse link
G Wars2 tryptophanyl tRNA synthetase 2 (mitochondrial) increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of WARS2 mRNA CTD PMID:18579281 NCBI chr 2:186,459,744...186,543,581
Ensembl chr 2:186,459,444...186,543,571 		JBrowse link
(4-chloro-2-methylphenoxy)acetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clcnka chloride voltage-gated channel Ka decreases activity EXP 2-Methyl-4-chlorophenoxyacetic Acid analog results in decreased activity of CLCNKA protein CTD PMID:15167890 NCBI chr 5:153,691,208...153,706,295
Ensembl chr 5:153,691,209...153,706,148 		JBrowse link
G Clcnkb chloride voltage-gated channel Kb decreases activity EXP 2-Methyl-4-chlorophenoxyacetic Acid analog results in decreased activity of CLCNKB protein CTD PMID:15167890 NCBI chr 5:153,710,086...153,733,162
Ensembl chr 5:153,710,094...153,732,153 		JBrowse link
G Slc1a2 solute carrier family 1 member 2 affects expression EXP 2-Methyl-4-chlorophenoxyacetic Acid affects the expression of SLC1A2 protein CTD PMID:16019039 NCBI chr 3:89,005,129...89,126,498
Ensembl chr 3:89,005,129...89,126,498 		JBrowse link
G Tnf tumor necrosis factor increases expression ISO 2-Methyl-4-chlorophenoxyacetic Acid results in increased expression of TNF protein CTD PMID:10883730 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
2,4-D term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of ABCB4 mRNA CTD PMID:9210621 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
G Alb albumin affects binding ISO 2,4-Dichlorophenoxyacetic Acid binds to ALB protein CTD PMID:9877224 PMID:11451446 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions
decreases expression		 ISO [Lipopolysaccharides co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of APAF1 mRNA; [Lipopolysaccharides co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of APAF1 protein
2,4-Dichlorophenoxyacetic Acid results in decreased expression of APAF1 mRNA; 2,4-Dichlorophenoxyacetic Acid results in decreased expression of APAF1 protein		 CTD PMID:33865415 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G Ar androgen receptor multiple interactions ISO 2,4-Dichlorophenoxyacetic Acid inhibits the reaction [Androgens binds to AR protein]; 2,4-Dichlorophenoxyacetic Acid promotes the reaction [Dihydrotestosterone results in increased localization of and results in increased activity of AR protein] CTD PMID:16107550 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Axin2 axin 2 multiple interactions
increases expression		 ISO [Lipopolysaccharides co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of AXIN2 mRNA
2,4-Dichlorophenoxyacetic Acid results in increased expression of AXIN2 mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of AXIN2 protein		 CTD PMID:34463001 NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231 		JBrowse link
G Becn1 beclin 1 multiple interactions
decreases expression		 EXP lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in decreased expression of BECN1 protein] CTD PMID:34464015 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Casp1 caspase 1 decreases cleavage
multiple interactions		 EXP 2,4-Dichlorophenoxyacetic Acid results in decreased cleavage of CASP1 protein
lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased cleavage of CASP1 protein]		 CTD PMID:34464015 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Ccdc120 coiled-coil domain containing 120 decreases expression ISO 2,4-Dichlorophenoxyacetic Acid results in decreased expression of CCDC120 mRNA CTD PMID:15878651 NCBI chr  X:14,753,594...14,772,745
Ensembl chr  X:14,753,696...14,772,743 		JBrowse link
G Ccl11 C-C motif chemokine ligand 11 increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of CCL11 protein CTD PMID:19467290 NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of CCL2 protein CTD PMID:19467290 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of CCL4 protein CTD PMID:19467290 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 increases expression
multiple interactions		 ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of CDK6 mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of CDK6 protein
[Lipopolysaccharides co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of CDK6 mRNA; [Lipopolysaccharides co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of CDK6 protein		 CTD PMID:33865415 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634 		JBrowse link
G Cldn1 claudin 1 decreases expression EXP 2,4-Dichlorophenoxyacetic Acid results in decreased expression of CLDN1 mRNA; 2,4-Dichlorophenoxyacetic Acid results in decreased expression of CLDN1 protein CTD PMID:28699141 NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724 		JBrowse link
G Clk1 CDC-like kinase 1 decreases expression ISO 2,4-Dichlorophenoxyacetic Acid results in decreased expression of CLK1 mRNA CTD PMID:15878651 NCBI chr 9:59,947,774...59,959,002
Ensembl chr 9:59,947,764...59,957,000 		JBrowse link
G Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase decreases expression EXP 2,4-Dichlorophenoxyacetic Acid results in decreased expression of CNP protein CTD PMID:18460445 NCBI chr10:85,511,164...85,517,723
Ensembl chr10:85,511,160...85,517,720 		JBrowse link
G Crat carnitine O-acetyltransferase increases activity ISO 2,4-Dichlorophenoxyacetic Acid results in increased activity of CRAT protein CTD PMID:1755024 NCBI chr 3:13,675,684...13,689,282
Ensembl chr 3:13,675,684...13,689,255 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression
multiple interactions		 ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of CREB1 mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of CREB1 protein
PPARB protein affects the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of CREB1 mRNA]		 CTD PMID:29633193 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 affects expression ISO 2,4-Dichlorophenoxyacetic Acid affects the expression of CYP17A1 mRNA CTD PMID:26838045 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP 2,4-Dichlorophenoxyacetic Acid results in increased expression of CYP1A1 mRNA CTD PMID:10910964 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression EXP 2,4-Dichlorophenoxyacetic Acid results in increased expression of CYP1A2 mRNA CTD PMID:10910964 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression EXP 2,4-Dichlorophenoxyacetic Acid results in increased expression of CYP1B1 mRNA CTD PMID:10910964 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Dbh dopamine beta-hydroxylase decreases expression EXP 2,4-Dichlorophenoxyacetic Acid results in decreased expression of DBH protein CTD PMID:16931444 NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248 		JBrowse link
G Dclre1c DNA cross-link repair 1C increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of DCLRE1C mRNA CTD PMID:15878651 NCBI chr17:74,775,828...74,810,089
Ensembl chr17:74,776,935...74,809,186 		JBrowse link
G Ddb2 damage specific DNA binding protein 2 increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of DDB2 mRNA CTD PMID:15878651 NCBI chr 3:77,185,114...77,207,650
Ensembl chr 3:77,185,109...77,207,631 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of DDIT3 mRNA CTD PMID:34626751 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Ephx1 epoxide hydrolase 1 increases activity ISO 2,4-Dichlorophenoxyacetic Acid results in increased activity of EPHX1 protein CTD PMID:3032197 NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235 		JBrowse link
G Ephx2 epoxide hydrolase 2 increases activity ISO 2,4-Dichlorophenoxyacetic Acid results in increased activity of EPHX2 protein CTD PMID:1755024 PMID:3032197 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615 		JBrowse link
G Foxo1 forkhead box O1 multiple interactions
increases expression		 ISO PPARB protein affects the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of FOXO1 mRNA]
2,4-Dichlorophenoxyacetic Acid results in increased expression of FOXO1 mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of FOXO1 protein		 CTD PMID:29633193 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790 		JBrowse link
G Fth1 ferritin heavy chain 1 increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of FTH1 mRNA CTD PMID:15878651 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424 		JBrowse link
G Ftl1 ferritin light chain 1 increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of FTL mRNA CTD PMID:15878651 NCBI chr 1:95,936,390...95,938,234
Ensembl chr 1:95,936,387...95,939,725 		JBrowse link
G Gfap glial fibrillary acidic protein increases expression EXP 2,4-Dichlorophenoxyacetic Acid results in increased expression of GFAP mRNA CTD PMID:22954530 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases expression ISO 2,4-Dichlorophenoxyacetic Acid results in decreased expression of HMGCR CTD PMID:26838045 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 decreases expression ISO 2,4-Dichlorophenoxyacetic Acid results in decreased expression of HMGCS1 CTD PMID:26838045 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100 		JBrowse link
G Ifng interferon gamma increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of IFNG CTD PMID:20728597 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il18 interleukin 18 increases expression
multiple interactions		 EXP 2,4-Dichlorophenoxyacetic Acid results in increased expression of IL18 mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of IL18 protein
lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of IL18 mRNA]; lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of IL18 protein]		 CTD PMID:34464015 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions		 EXP 2,4-Dichlorophenoxyacetic Acid results in increased expression of IL1B mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of IL1B protein
lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of IL1B mRNA]; lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of IL1B protein]		 CTD PMID:34464015 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 decreases expression ISO 2,4-Dichlorophenoxyacetic Acid results in decreased expression of IL1RL1 mRNA CTD PMID:15878651 NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256 		JBrowse link
G Il2 interleukin 2 increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of IL2 CTD PMID:20728597 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il2ra interleukin 2 receptor subunit alpha increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of IL2RA CTD PMID:20728597 NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697 		JBrowse link
G Il4 interleukin 4 increases expression
increases secretion		 ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of IL4 protein
2,4-Dichlorophenoxyacetic Acid results in increased secretion of IL4 protein		 CTD PMID:19467290 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il5 interleukin 5 increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of IL5 protein CTD PMID:19467290 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Il6 interleukin 6 increases expression ISO
EXP		 2,4-Dichlorophenoxyacetic Acid results in increased expression of IL6 protein CTD PMID:19467290 PMID:34464015 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itgb1 integrin subunit beta 1 increases expression
multiple interactions		 ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of ITGB1 mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of ITGB1 protein
[Lipopolysaccharides co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of ITGB1 mRNA; [Lipopolysaccharides co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of ITGB1 protein		 CTD PMID:33865415 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195 		JBrowse link
G Ldha lactate dehydrogenase A decreases expression EXP 2,4-Dichlorophenoxyacetic Acid results in decreased expression of LDHA mRNA; 2,4-Dichlorophenoxyacetic Acid results in decreased expression of LDHA protein CTD PMID:23538319 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta decreases expression
multiple interactions		 EXP 2,4-Dichlorophenoxyacetic Acid results in decreased expression of MAP1LC3B mRNA
lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in decreased expression of MAP1LC3B mRNA]		 CTD PMID:34464015 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Mbp myelin basic protein decreases expression EXP 2,4-Dichlorophenoxyacetic Acid results in decreased expression of MBP protein CTD PMID:18460445 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases methylation ISO 2,4-Dichlorophenoxyacetic Acid results in decreased methylation of MYC promoter CTD PMID:11857776 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
increases expression		 ISO [Lipopolysaccharides co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of NFKB1 mRNA; [Lipopolysaccharides co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of NFKB1 protein
2,4-Dichlorophenoxyacetic Acid results in increased expression of NFKB1 mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of NFKB1 protein		 CTD PMID:33865415 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 increases expression
multiple interactions		 EXP 2,4-Dichlorophenoxyacetic Acid results in increased expression of NLRP3 mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of NLRP3 protein
lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of NLRP3 mRNA]; lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of NLRP3 protein]		 CTD PMID:34464015 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO 2,4-Dichlorophenoxyacetic Acid binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Ocln occludin decreases expression EXP 2,4-Dichlorophenoxyacetic Acid results in decreased expression of OCLN mRNA CTD PMID:28699141 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150 		JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide decreases secretion EXP 2,4-Dichlorophenoxyacetic Acid results in decreased secretion of OXT protein CTD PMID:20122984 NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of PCNA mRNA CTD PMID:15878651 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pfkm phosphofructokinase, muscle decreases expression EXP 2,4-Dichlorophenoxyacetic Acid results in decreased expression of PFKM mRNA; 2,4-Dichlorophenoxyacetic Acid results in decreased expression of PFKM protein CTD PMID:23538319 NCBI chr 7:129,221,679...129,259,192
Ensembl chr 7:129,221,653...129,259,192 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases response to substance ISO PPARA protein results in increased susceptibility to 2,4-Dichlorophenoxyacetic Acid CTD PMID:26838045 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions
increases expression		 ISO PPARB protein affects the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of CREB1 mRNA]; PPARB protein affects the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of FOXO1 mRNA]
2,4-Dichlorophenoxyacetic Acid results in increased expression of PPARB mRNA		 CTD PMID:29633193 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968 		JBrowse link
G Prl prolactin decreases secretion EXP 2,4-Dichlorophenoxyacetic Acid results in decreased secretion of PRL protein CTD PMID:20122984 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Ptger3 prostaglandin E receptor 3 decreases expression ISO 2,4-Dichlorophenoxyacetic Acid results in decreased expression of PTGER3 mRNA CTD PMID:15878651 NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434 		JBrowse link
G Pycard PYD and CARD domain containing increases expression
multiple interactions		 EXP 2,4-Dichlorophenoxyacetic Acid results in increased expression of PYCARD protein
lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of PYCARD protein]		 CTD PMID:34464015 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Slc16a3 solute carrier family 16 member 3 decreases expression
increases expression		 EXP 2,4-Dichlorophenoxyacetic Acid results in decreased expression of SLC16A3 mRNA
2,4-Dichlorophenoxyacetic Acid results in increased expression of SLC16A3 mRNA		 CTD PMID:23538319 NCBI chr10:106,212,679...106,222,564
Ensembl chr10:106,212,778...106,222,562 		JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions ISO Potassium promotes the reaction [SLC22A12 protein results in increased uptake of 2,4-Dichlorophenoxyacetic Acid] CTD PMID:15284287 NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555 		JBrowse link
G Slc22a20 solute carrier family 22 member 20 multiple interactions ISO 2,4-Dichlorophenoxyacetic Acid inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate] CTD PMID:16478971 NCBI chr 1:203,257,374...203,273,848
Ensembl chr 1:203,257,374...203,273,822 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 increases uptake
multiple interactions		 EXP
ISO		 SLC22A6 protein results in increased uptake of 2,4-Dichlorophenoxyacetic Acid
p-Aminohippuric Acid inhibits the reaction [SLC22A6 protein results in increased uptake of 2,4-Dichlorophenoxyacetic Acid]		 CTD PMID:16857889 PMID:17255469 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression
increases expression		 EXP 2,4-Dichlorophenoxyacetic Acid results in decreased expression of SLC2A3 mRNA; 2,4-Dichlorophenoxyacetic Acid results in decreased expression of SLC2A3 protein
2,4-Dichlorophenoxyacetic Acid results in increased expression of SLC2A3 mRNA		 CTD PMID:23538319 NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
increases expression		 EXP lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of SQSTM1 mRNA]; lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of SQSTM1 protein]
2,4-Dichlorophenoxyacetic Acid results in increased expression of SQSTM1 mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of SQSTM1 protein		 CTD PMID:34464015 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of SRXN1 mRNA CTD PMID:34626751 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448 		JBrowse link
G Th tyrosine hydroxylase increases expression EXP 2,4-Dichlorophenoxyacetic Acid results in increased expression of TH protein CTD PMID:16931444 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Thrb thyroid hormone receptor beta affects binding ISO 2,4-Dichlorophenoxyacetic Acid binds to THRB protein CTD PMID:27410513 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
G Tjp1 tight junction protein 1 decreases expression EXP 2,4-Dichlorophenoxyacetic Acid results in decreased expression of TJP1 mRNA; 2,4-Dichlorophenoxyacetic Acid results in decreased expression of TJP1 protein CTD PMID:28699141 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 ISO
EXP		 2,4-Dichlorophenoxyacetic Acid results in increased expression of TNF
2,4-Dichlorophenoxyacetic Acid results in increased expression of TNF protein
lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of TNF protein]		 CTD PMID:20728597 PMID:34464015 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression		 ISO [Lipopolysaccharides co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of TRP53 mRNA; [Lipopolysaccharides co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of TRP53 protein
2,4-Dichlorophenoxyacetic Acid results in increased expression of TRP53 mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of TRP53 protein		 CTD PMID:33865415 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Usp19 ubiquitin specific peptidase 19 increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of USP19 mRNA CTD PMID:15878651 NCBI chr 8:109,190,727...109,201,761
Ensembl chr 8:109,190,724...109,201,741 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO 2,4-Dichlorophenoxyacetic Acid results in decreased expression of VEGFA mRNA CTD PMID:15878651 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      biological role 20011
        biochemical role 19671
          metabolite 19631
            glycolic acid 179
              (benzyloxy)acetic acid 0
              2-phosphoglycolic acid 0
              caffeoylglycolic acid methyl ester 0
              glycolate ester + 0
              phenoxyacetic acid + 176
              phosphoglycolohydroxamic acid 0
              ureidoglycolic acid + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic group 18988
                              organic divalent group 18950
                                organodiyl group 18974
                                  carbonyl group 18903
                                    carbonyl compound 18925
                                      carboxylic acid 18597
                                        hydroxy carboxylic acid 3728
                                          hydroxy monocarboxylic acid 3723
                                            2-hydroxy monocarboxylic acid 2993
                                              glycolic acid 179
                                                (benzyloxy)acetic acid 0
                                                2-phosphoglycolic acid 0
                                                caffeoylglycolic acid methyl ester 0
                                                glycolate ester + 0
                                                phenoxyacetic acid + 176
                                                phosphoglycolohydroxamic acid 0
                                                ureidoglycolic acid + 0
paths to the root