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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:3',5'-cyclic AMP
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Accession:CHEBI:17489 term browser browse the term
Definition:A 3',5'-cyclic purine nucleotide having having adenine as the nucleobase.
Synonyms:exact_synonym: adenosine 3',5'-(hydrogen phosphate)
 related_synonym: Adenosine 3',5'-cyclic phosphate;   Adenosine 3',5'-phosphate;   Cyclic AMP;   Cyclic adenylic acid;   Formula=C10H12N5O6P;   InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/t4-,6-,7-,10-/m1/s1;   InChIKey=IVOMOUWHDPKRLL-KQYNXXCUSA-N;   SMILES=Nc1ncnc2n(cnc12)[C@@H]1O[C@@H]2COP(O)(=O)O[C@H]2[C@H]1O;   adenosine 3',5'-cyclic monophosphate;   cAMP
 alt_id: CHEBI:11673;   CHEBI:1325;   CHEBI:19827;   CHEBI:41588
 xref: Beilstein:52645;   CAS:60-92-4;   DrugBank:DB02527;   HMDB:HMDB0000058;   KEGG:C00575;   KNApSAcK:C00001497
 xref_mesh: MESH:D000242
 xref: MetaCyc:CAMP;   PDBeChem:CMP;   PMID:16295522;   PMID:18372334;   PMID:22770225;   Reaxys:52645;   Wikipedia:Cyclic_AMP
 cyclic_relationship: is_conjugate_acid_of CHEBI:58165


show annotations for term's descendants           Sort by:
3',5'-cyclic AMP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP7B ATPase copper transporting beta multiple interactions EXP Cyclic AMP inhibits the reaction [Copper binds to ATP7B protein] CTD PMID:21084060 NCBI chr11:15,892,549...15,942,070
Ensembl chr11:15,876,612...15,942,064 		JBrowse link
G CALCB calcitonin-related polypeptide beta increases abundance EXP CALCA protein results in increased abundance of Cyclic AMP CTD PMID:18463244 NCBI chr 2:44,043,135...44,048,651 JBrowse link
G DUOX2 dual oxidase 2 increases expression EXP Cyclic AMP results in increased expression of DUOX2 mRNA CTD PMID:10601291 NCBI chr 1:126,620,468...126,641,406
Ensembl chr 1:126,620,510...126,641,406 		JBrowse link
G GCG glucagon affects response to substance
increases abundance		 EXP Cyclic AMP affects the susceptibility to GCG protein
GCG protein results in increased abundance of Cyclic AMP		 CTD PMID:6253273 NCBI chr15:68,800,557...68,810,268
Ensembl chr15:68,800,560...68,810,242 		JBrowse link
G GNRH1 gonadotropin releasing hormone 1 multiple interactions
increases abundance		 EXP [Cobalt binds to GNRH1 protein] which results in increased abundance of Cyclic AMP
GNRH1 protein results in increased abundance of Cyclic AMP		 CTD PMID:15833593 NCBI chr14:9,442,971...9,447,521
Ensembl chr14:9,442,971...9,453,035 		JBrowse link
bucladesine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 increases expression EXP Bucladesine results in increased expression of ATP1A1 protein CTD PMID:28438630 NCBI chr 4:104,353,506...104,384,321
Ensembl chr 4:104,353,508...104,384,547 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 5052
    role 5044
      biological role 5016
        biochemical role 4938
          metabolite 4926
            prokaryotic metabolite 375
              bacterial metabolite 368
                Escherichia coli metabolite 357
                  3',5'-cyclic AMP 6
                    (Rp)-cAMPS 0
                    (Sp)-8-bromo-cAMPS 0
                    (Sp)-cAMPS 0
                    1-NO-cAMP 0
                    2-(6-aminohexylamino)-cAMP 0
                    2-(dimethylamino)-cAMP 0
                    6-(dimethylamino)-cPuMP 0
                    8-(4-chlorophenylthio)-cAMP 0
                    8-(6-aminohexylamino)-cAMP 0
                    8-(6-aminohexylthio)-cAMP 0
                    8-Br-cAMP 0
                    8-PIP-cAMP 0
                    N(6)-(6-aminohexyl)-cAMP 0
                    N(6)-butyryl-cAMP 0
                    bucladesine 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 5052
    subatomic particle 5043
      composite particle 5043
        hadron 5071
          baryon 5043
            nucleon 5043
              atomic nucleus 5043
                atom 5043
                  main group element atom 5013
                    p-block element atom 5010
                      chalcogen 4915
                        oxygen atom 4910
                          oxygen molecular entity 4883
                            hydroxides 4835
                              oxoacid 403
                                pnictogen oxoacid 87
                                  phosphorus oxoacid 84
                                    phosphoric acids 54
                                      phosphoric acid 53
                                        phosphoric acid derivative 49
                                          phosphate 49
                                            organic phosphate 49
                                              carbohydrate phosphate 26
                                                phospho sugar 14
                                                  aldose phosphate 14
                                                    aldopentose phosphate 14
                                                      ribose phosphate 14
                                                        ribonucleotide 14
                                                          purine ribonucleotide 14
                                                            adenyl ribonucleotide 11
                                                              3',5'-cyclic AMP 6
                                                                (Rp)-cAMPS 0
                                                                (Sp)-8-bromo-cAMPS 0
                                                                (Sp)-cAMPS 0
                                                                1-NO-cAMP 0
                                                                2-(6-aminohexylamino)-cAMP 0
                                                                2-(dimethylamino)-cAMP 0
                                                                6-(dimethylamino)-cPuMP 0
                                                                8-(4-chlorophenylthio)-cAMP 0
                                                                8-(6-aminohexylamino)-cAMP 0
                                                                8-(6-aminohexylthio)-cAMP 0
                                                                8-Br-cAMP 0
                                                                8-PIP-cAMP 0
                                                                N(6)-(6-aminohexyl)-cAMP 0
                                                                N(6)-butyryl-cAMP 0
                                                                bucladesine 1
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