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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:C.I. Natural Red 20
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Accession:CHEBI:174748 term browser browse the term
Synonyms:exact_synonym: 5,8-dihydroxy-2-(1-hydroxy-4-methylpent-3-enyl)naphthalene-1,4-dione
 related_synonym: Formula=C16H16O5;   InChI=1S/C16H16O5/c1-8(2)3-4-10(17)9-7-13(20)14-11(18)5-6-12(19)15(14)16(9)21/h3,5-7,10,17-19H,4H2,1-2H3;   InChIKey=NEZONWMXZKDMKF-UHFFFAOYSA-N;   SMILES=OC(C=1C(=O)C=2C(C(=O)C1)=C(O)C=CC2O)CC=C(C)C
 xref: CAS:54952-43-1;   Chemspider:5019;   HMDB:HMDB0030579
 xref_mesh: MESH:C016101


show annotations for term's descendants           Sort by:
C.I. Natural Red 20 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle decreases expression ISO shikonin results in decreased expression of ACTA2 mRNA CTD PMID:25591861 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions		 ISO shikonin results in decreased phosphorylation of AKT1 protein
shikonin promotes the reaction [Oxygen deficiency results in increased phosphorylation of AKT1 protein]		 CTD PMID:24463199 PMID:28684144 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Areg amphiregulin decreases expression ISO shikonin results in decreased expression of AREG mRNA CTD PMID:37268198 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535 		JBrowse link
G Atf3 activating transcription factor 3 multiple interactions
increases expression		 ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of ATF3 mRNA]
shikonin results in increased expression of ATF3 protein
shikonin results in increased expression of ATF3 mRNA; shikonin results in increased expression of ATF3 protein
[shikonin results in increased acetylation of HDAC1 protein] which results in increased expression of ATF3 protein; ATF3 protein promotes the reaction [shikonin results in decreased expression of GPX4 protein]; ATF3 protein promotes the reaction [shikonin results in decreased expression of SLC7A11 protein]; MYC protein inhibits the reaction [shikonin results in increased expression of ATF3 mRNA]; MYC protein inhibits the reaction [shikonin results in increased expression of ATF3 protein]; shikonin promotes the reaction [HDAC1 protein binds to ATF3 promoter]		 CTD PMID:25451590 PMID:37268198 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions EXP shikonin inhibits the reaction [Glutamic Acid results in increased expression of ATF6 protein] CTD PMID:35028790 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP [Enzyme Activators results in increased activity of EIF2AK3 protein] inhibits the reaction [shikonin inhibits the reaction [Glutamic Acid results in increased expression of BAX protein]]; shikonin inhibits the reaction [Glutamic Acid results in increased expression of and affects the localization of BAX protein]; shikonin inhibits the reaction [Thapsigargin results in increased expression of BAX protein] CTD PMID:35028790 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO
EXP		 shikonin results in decreased expression of BCL2 protein
1,3-benzothiazol-2-yl(2-((2-(3-pyridinyl)ethyl)amino)-4-pyrimidinyl)acetonitrile promotes the reaction [shikonin inhibits the reaction [Glutamic Acid results in decreased expression of BCL2 protein]]; MKC8866 promotes the reaction [shikonin inhibits the reaction [Glutamic Acid results in decreased expression of BCL2 protein]]; shikonin inhibits the reaction [Glutamic Acid results in decreased expression of BCL2 protein]; shikonin inhibits the reaction [Thapsigargin results in decreased expression of BCL2 protein]; ursodoxicoltaurine inhibits the reaction [shikonin inhibits the reaction [Glutamic Acid results in decreased expression of BCL2 protein]]		 CTD PMID:25591861 PMID:35028790 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp12 caspase 12 multiple interactions EXP [Enzyme Activators results in increased activity of EIF2AK3 protein] inhibits the reaction [shikonin inhibits the reaction [Glutamic Acid results in increased cleavage of CASP12 protein]]; shikonin inhibits the reaction [Glutamic Acid results in increased expression of and results in increased cleavage of CASP12 protein] CTD PMID:35028790 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions		 ISO
EXP		 shikonin results in increased cleavage of CASP3 protein
shikonin inhibits the reaction [Glutamic Acid results in increased expression of CASP3 protein modified form]
shikonin inhibits the reaction [Benzene results in increased expression of CASP3 mRNA]		 CTD PMID:25591861 PMID:35028790 PMID:36306860 PMID:37268198 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO shikonin inhibits the reaction [Benzene results in increased expression of CASP7 mRNA] CTD PMID:36306860 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO shikonin inhibits the reaction [Benzene results in increased cleavage of CASP9 protein]; shikonin inhibits the reaction [Benzene results in increased expression of CASP9 mRNA] CTD PMID:36306860 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccl1 C-C motif chemokine ligand 1 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of CCL1 mRNA] CTD PMID:25451590 NCBI chr10:67,128,331...67,131,109
Ensembl chr10:67,128,331...67,131,159 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of CCL4 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of CCL4 mRNA] CTD PMID:25451590 NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Ccl7 C-C motif chemokine ligand 7 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of CCL7 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of CCL7 mRNA] CTD PMID:25451590 NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO
EXP		 shikonin results in decreased expression of CCND1 protein CTD PMID:16061028 PMID:28684144 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccne1 cyclin E1 decreases expression EXP shikonin results in decreased expression of CCNE1 protein CTD PMID:16061028 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cdh1 cadherin 1 multiple interactions
increases expression		 ISO shikonin inhibits the reaction [[Tobacco Smoke Pollution results in increased abundance of Particulate Matter] which results in decreased expression of CDH1 protein]
shikonin results in increased expression of CDH1 protein		 CTD PMID:35787437 PMID:37268198 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh2 cadherin 2 multiple interactions
decreases expression		 ISO shikonin inhibits the reaction [[Tobacco Smoke Pollution results in increased abundance of Particulate Matter] which results in increased expression of CDH2 protein]
shikonin results in decreased expression of CDH2 protein		 CTD PMID:35787437 PMID:37268198 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO
EXP		 shikonin results in increased expression of CDKN1A protein CTD PMID:16061028 PMID:28684144 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO shikonin results in decreased expression of COL1A1 mRNA CTD PMID:25591861 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression ISO shikonin results in decreased expression of COL3A1 mRNA CTD PMID:25591861 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Csf1 colony stimulating factor 1 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of CSF1 mRNA] CTD PMID:25451590 NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704 		JBrowse link
G Csrnp1 cysteine and serine rich nuclear protein 1 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of AXUD1 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of AXUD1 mRNA] CTD PMID:25451590 NCBI chr 8:119,704,712...119,717,767
Ensembl chr 8:119,704,713...119,718,183 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO shikonin inhibits the reaction [[Tobacco Smoke Pollution results in increased abundance of Particulate Matter] which results in increased expression of CXCL1 protein] CTD PMID:35787437 NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity EXP
ISO		 shikonin results in decreased activity of CYP1A2 protein CTD PMID:28941798 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases activity EXP shikonin results in decreased activity of CYP2B1 protein CTD PMID:28941798 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases activity ISO shikonin results in decreased activity of CYP2B6 protein CTD PMID:28941798 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases activity EXP shikonin results in decreased activity of CYP2C11 protein CTD PMID:28941798 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2d1 cytochrome P450, family 2, subfamily d, polypeptide 1 decreases activity EXP shikonin results in decreased activity of CYP2D1 protein CTD PMID:28941798 NCBI chr 7:113,908,950...113,913,420
Ensembl chr 7:113,908,947...113,922,084 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO shikonin results in decreased activity of CYP2D6 protein CTD PMID:28941798 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity EXP
ISO		 shikonin results in decreased activity of CYP2E1 protein CTD PMID:28941798 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity
multiple interactions		 EXP
ISO		 shikonin results in decreased activity of CYP3A2 protein
shikonin inhibits the reaction [CYP3A2 protein results in increased hydroxylation of Midazolam]
shikonin results in decreased activity of CYP3A4 protein		 CTD PMID:28941798 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions EXP [Enzyme Activators results in increased activity of EIF2AK3 protein] inhibits the reaction [shikonin inhibits the reaction [Glutamic Acid results in increased expression of DDIT3 protein]]; shikonin inhibits the reaction [Glutamic Acid results in increased expression of DDIT3 protein] CTD PMID:35028790 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dusp1 dual specificity phosphatase 1 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of DUSP1 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of DUSP1 mRNA] CTD PMID:25451590 NCBI chr10:16,680,478...16,683,275 JBrowse link
G Dusp6 dual specificity phosphatase 6 multiple interactions ISO shikonin inhibits the reaction [Calcimycin results in increased expression of DUSP6 mRNA] CTD PMID:25451590 NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185 		JBrowse link
G Egr2 early growth response 2 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of EGR2 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of EGR2 mRNA] CTD PMID:25451590 NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562 		JBrowse link
G Egr3 early growth response 3 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of EGR3 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of EGR3 mRNA] CTD PMID:25451590 NCBI chr15:45,150,335...45,156,052
Ensembl chr15:45,150,567...45,154,627 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions EXP [Enzyme Activators results in increased activity of EIF2AK3 protein] inhibits the reaction [shikonin inhibits the reaction [Glutamic Acid results in increased cleavage of CASP12 protein]]; [Enzyme Activators results in increased activity of EIF2AK3 protein] inhibits the reaction [shikonin inhibits the reaction [Glutamic Acid results in increased expression of BAX protein]]; [Enzyme Activators results in increased activity of EIF2AK3 protein] inhibits the reaction [shikonin inhibits the reaction [Glutamic Acid results in increased expression of DDIT3 protein]]; GSK2656157 promotes the reaction [shikonin inhibits the reaction [Glutamic Acid results in increased phosphorylation of EIF2AK3 protein]]; shikonin inhibits the reaction [Glutamic Acid results in increased phosphorylation of EIF2AK3 protein]; shikonin inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2AK3 protein]; ursodoxicoltaurine promotes the reaction [shikonin inhibits the reaction [Glutamic Acid results in increased phosphorylation of EIF2AK3 protein]] CTD PMID:35028790 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions EXP GSK2656157 promotes the reaction [shikonin inhibits the reaction [Glutamic Acid results in increased phosphorylation of EIF2S1 protein]]; shikonin inhibits the reaction [Glutamic Acid results in increased phosphorylation of EIF2S1 protein]; shikonin inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2S1 protein]; ursodoxicoltaurine promotes the reaction [shikonin inhibits the reaction [Glutamic Acid results in increased phosphorylation of EIF2S1 protein]] CTD PMID:35028790 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO shikonin affects the reaction [Oxygen deficiency affects the phosphorylation of EIF4EBP1 protein] CTD PMID:28684144 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions EXP shikonin inhibits the reaction [Glutamic Acid results in increased phosphorylation of ERN1 protein] CTD PMID:35028790 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of FOS mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of FOS mRNA] CTD PMID:25451590 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of FOSB mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of FOSB mRNA] CTD PMID:25451590 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465 		JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions
decreases expression		 ISO ATF3 protein promotes the reaction [shikonin results in decreased expression of GPX4 protein] CTD PMID:37268198 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982 		JBrowse link
G Hdac1 histone deacetylase 1 multiple interactions ISO [shikonin results in increased acetylation of HDAC1 protein] which results in increased expression of ATF3 protein; shikonin promotes the reaction [HDAC1 protein binds to ATF3 promoter] CTD PMID:37268198 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
decreases expression		 ISO shikonin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]
shikonin results in decreased expression of HIF1A protein		 CTD PMID:28684144 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO shikonin results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Il13 interleukin 13 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of IL13 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of IL13 mRNA] CTD PMID:25451590 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO shikonin inhibits the reaction [Benzene results in increased expression of IL1B mRNA] CTD PMID:36306860 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Itgb1 integrin subunit beta 1 decreases expression ISO shikonin results in decreased expression of ITGB1 mRNA; shikonin results in decreased expression of ITGB1 protein CTD PMID:23562787 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO shikonin inhibits the reaction [Calcimycin results in increased expression of JUN mRNA] CTD PMID:25451590 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of MAP3K8 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of MAP3K8 mRNA] CTD PMID:25451590 NCBI chr17:53,382,908...53,403,216
Ensembl chr17:53,383,131...53,403,216 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
decreases phosphorylation		 ISO Acetylcysteine inhibits the reaction [shikonin results in decreased phosphorylation of MAPK1 protein]
shikonin results in increased phosphorylation of MAPK1 protein		 CTD PMID:23562787 PMID:24463199 PMID:25591861 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
increases phosphorylation
multiple interactions		 ISO shikonin results in decreased phosphorylation of MAPK3 protein
shikonin results in increased phosphorylation of MAPK3 protein
Acetylcysteine inhibits the reaction [shikonin results in decreased phosphorylation of MAPK3 protein]		 CTD PMID:23562787 PMID:24463199 PMID:25591861 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP shikonin inhibits the reaction [Glutamic Acid results in increased phosphorylation of MAPK8 protein] CTD PMID:35028790 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions EXP shikonin inhibits the reaction [Glutamic Acid results in increased phosphorylation of MAPK9 protein] CTD PMID:35028790 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO shikonin results in decreased expression of MMP2 protein CTD PMID:37268198 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp3 matrix metallopeptidase 3 decreases expression ISO shikonin results in decreased expression of MMP3 protein CTD PMID:37268198 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961 		JBrowse link
G Mmp7 matrix metallopeptidase 7 decreases expression ISO shikonin results in decreased expression of MMP7 protein CTD PMID:37268198 NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO shikonin results in decreased expression of MMP9 protein CTD PMID:37268198 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO shikonin inhibits the reaction [Calcimycin results in increased expression of MT2 mRNA] CTD PMID:25451590 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO shikonin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of MTOR protein] CTD PMID:28684144 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO MYC protein inhibits the reaction [shikonin results in increased expression of ATF3 mRNA]; MYC protein inhibits the reaction [shikonin results in increased expression of ATF3 protein] CTD PMID:37268198 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO shikonin inhibits the reaction [Benzene results in increased expression of and affects the localization of NFE2L2 protein] CTD PMID:36306860 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkbid NFKB inhibitor delta multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of NFKBID mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of NFKBID mRNA] CTD PMID:25451590 NCBI chr 1:85,679,353...85,690,415
Ensembl chr 1:85,680,861...85,690,447 		JBrowse link
G Nfkbiz NFKB inhibitor zeta multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of NFKBIZ mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of NFKBIZ mRNA] CTD PMID:25451590 NCBI chr11:44,782,676...44,810,722
Ensembl chr11:44,782,676...44,810,723 		JBrowse link
G Nkd2 NKD inhibitor of WNT signaling pathway 2 decreases expression ISO shikonin results in decreased expression of NKD2 mRNA CTD PMID:37268198 NCBI chr 1:29,442,898...29,470,839
Ensembl chr 1:29,441,328...29,470,821 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of NR4A1 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of NR4A1 mRNA] CTD PMID:25451590 NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of NR4A2 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of NR4A2 mRNA] CTD PMID:25451590 NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877 		JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of NR4A3 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of NR4A3 mRNA] CTD PMID:25451590 NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733 		JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of OLR1 mRNA] CTD PMID:25451590 NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage		 ISO Acetylcysteine inhibits the reaction [shikonin results in increased cleavage of PARP1 protein] CTD PMID:24463199 PMID:37268198 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression EXP shikonin results in decreased expression of PCNA protein CTD PMID:16061028 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pkm pyruvate kinase M1/2 multiple interactions ISO shikonin inhibits the reaction [[Tobacco Smoke Pollution results in increased abundance of Particulate Matter] which results in increased expression of PKM protein] CTD PMID:35787437 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599 		JBrowse link
G Plk3 polo-like kinase 3 multiple interactions ISO shikonin inhibits the reaction [Calcimycin results in increased expression of PLK3 mRNA] CTD PMID:25451590 NCBI chr 5:130,607,142...130,612,317
Ensembl chr 5:130,607,142...130,612,317 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A multiple interactions ISO shikonin inhibits the reaction [Calcimycin results in increased expression of PPP1R15A mRNA] CTD PMID:25451590 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of PTGS2 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of PTGS2 mRNA] CTD PMID:25451590 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO shikonin inhibits the reaction [Benzene results in increased expression of RELA protein] CTD PMID:36306860 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 multiple interactions ISO shikonin promotes the reaction [RIPK1 protein binds to RIPK3 protein] CTD PMID:23261677 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 multiple interactions ISO shikonin promotes the reaction [RIPK1 protein binds to RIPK3 protein] CTD PMID:23261677 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO shikonin promotes the reaction [Oxygen deficiency results in decreased phosphorylation of RPS6KB1 protein] CTD PMID:28684144 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of SERPINE1 mRNA] CTD PMID:25451590 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression
multiple interactions		 ISO shikonin results in decreased expression of SLC7A11 protein
ATF3 protein promotes the reaction [shikonin results in decreased expression of SLC7A11 protein]		 CTD PMID:37268198 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Snai1 snail family transcriptional repressor 1 decreases expression ISO shikonin results in decreased expression of SNAI1 protein CTD PMID:37268198 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969 		JBrowse link
G Snai2 snail family transcriptional repressor 2 decreases expression ISO shikonin results in decreased expression of SNAI2 protein CTD PMID:37268198 NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200 		JBrowse link
G Tagap T-cell activation RhoGTPase activating protein multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of TAGAP mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of TAGAP mRNA] CTD PMID:25451590 NCBI chr 1:47,170,725...47,179,705
Ensembl chr 1:47,170,725...47,179,792 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO shikonin results in increased expression of TIMP2 protein CTD PMID:37268198 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO shikonin inhibits the reaction [[Tobacco Smoke Pollution results in increased abundance of Particulate Matter] which results in increased expression of TNF protein]; shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of TNF mRNA]; shikonin inhibits the reaction [Benzene results in increased expression of TNF mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of TNF mRNA] CTD PMID:25451590 PMID:35787437 PMID:36306860 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO shikonin results in increased expression of TP53 protein CTD PMID:28684144 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions EXP
ISO		 shikonin inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Estradiol] CTD PMID:31128210 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 multiple interactions ISO shikonin inhibits the reaction [UGT1A3 protein results in increased glucuronidation of Chenodeoxycholic Acid] CTD PMID:31128210 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 multiple interactions ISO shikonin inhibits the reaction [UGT1A9 protein results in increased glucuronidation of Propofol] CTD PMID:31128210 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions ISO shikonin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Zidovudine] CTD PMID:31128210 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions EXP MKC8866 promotes the reaction [shikonin inhibits the reaction [Glutamic Acid results in increased expression of XBP1 protein alternative form]]; shikonin inhibits the reaction [Glutamic Acid results in increased expression of XBP1 protein alternative form] CTD PMID:35028790 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
G Zfp36 zinc finger protein 36 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of ZFP36 mRNA]; shikonin inhibits the reaction [Calcimycin results in increased expression of ZFP36 mRNA] CTD PMID:25451590 NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564 		JBrowse link
G Zfp36l1 zinc finger protein 36, C3H type-like 1 multiple interactions ISO shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of ZFP36L1 mRNA] CTD PMID:25451590 NCBI chr 6:98,930,705...98,935,748
Ensembl chr 6:98,930,718...98,935,748 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    chemical entity 19840
      group 19768
        inorganic group 19361
          oxo group 18858
            organic oxo compound 18858
              carbonyl compound 18858
                ketone 17163
                  cyclic ketone 15681
                    quinone 8644
                      naphthoquinone 1474
                        C.I. Natural Red 20 96
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            heteroorganic entity 19459
                              organochalcogen compound 19222
                                organooxygen compound 19137
                                  carbonyl compound 18858
                                    ketone 17163
                                      cyclic ketone 15681
                                        quinone 8644
                                          naphthoquinone 1474
                                            C.I. Natural Red 20 96
paths to the root