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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dithioerythritol
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Accession:CHEBI:17456 term browser browse the term
Definition:The meso-diastereomer of 1,4-dimercaptobutane-2,3-diol; a sulfur-containing sugar derived from the monosaccharide erythrose; and an epimer of dithiothreitol.
Synonyms:exact_synonym: (2R,3S)-1,4-disulfanylbutane-2,3-diol
 related_synonym: (2R*,3S*)-1,4-dimercapto-2,3-butanediol;   (2R,3S)-1,4-dimercaptobutane-2,3-diol;   1,4-dithioerythritol;   DTE;   Formula=C4H10O2S2;   InChI=1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4+;   InChIKey=VHJLVAABSRFDPM-ZXZARUISSA-N;   SMILES=O[C@@H](CS)[C@H](O)CS;   erythro-1,4-Dimercapto-2,3-butanediol
 alt_id: CHEBI:14184;   CHEBI:23851;   CHEBI:42239;   CHEBI:4662
 xref: Beilstein:1719756;   CAS:6892-68-8;   DrugBank:DB01692;   Gmelin:863505;   KEGG:C00950
 xref_mesh: MESH:D004226
 xref: PDBeChem:DTU;   PMID:14192894;   PMID:16901854;   PMID:22684514;   PMID:22845804;   PMID:23402788;   Reaxys:1719756;   Wikipedia:Dithioerythritol


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dithioerythritol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc1a5 solute carrier family 1 member 5 multiple interactions EXP Dithioerythritol inhibits the reaction [Thiazoles analog results in decreased activity of SLC1A5 protein] CTD PMID:23010140 NCBI chr 1:78,710,686...78,724,789
Ensembl chr 1:78,710,539...78,724,794
JBrowse link
G Slc22a4 solute carrier family 22 member 4 multiple interactions ISO Dithioerythritol inhibits the reaction [Cadmium results in decreased activity of SLC22A4 protein]; Dithioerythritol inhibits the reaction [Mercury results in decreased activity of SLC22A4 protein]; Dithioerythritol inhibits the reaction [methylmercuric chloride results in decreased activity of SLC22A4 protein] CTD PMID:25490951 NCBI chr10:39,334,972...39,373,508 JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions EXP Dithioerythritol inhibits the reaction [Mercuric Chloride results in decreased transport of SLC22A5 protein]; Dithioerythritol inhibits the reaction [Methylmercury Compounds results in decreased transport of SLC22A5 protein]; Dithioerythritol inhibits the reaction [Omeprazole inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine]] CTD PMID:19041296 PMID:22900493 NCBI chr10:39,201,101...39,228,090
Ensembl chr10:39,201,107...39,323,853
JBrowse link
G Slc25a20 solute carrier family 25 member 20 multiple interactions EXP
ISO
Dithioerythritol inhibits the reaction [Hydrogen Peroxide results in decreased activity of SLC25A20 protein]
Dithioerythritol inhibits the reaction [Mercuric Chloride results in decreased activity of SLC25A20 protein]; Dithioerythritol inhibits the reaction [methylmercuric chloride results in decreased activity of SLC25A20 protein]
CTD PMID:23402788 PMID:25849418 NCBI chr 8:117,455,308...117,476,762
Ensembl chr 8:117,455,262...117,476,734
JBrowse link

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  CHEBI ontology 19840
    role 19790
      chemical role 19308
        reducing agent 187
          dithioerythritol 4
Path 2
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  CHEBI ontology 19840
    subatomic particle 19838
      composite particle 19838
        hadron 19838
          baryon 19838
            nucleon 19838
              atomic nucleus 19838
                atom 19838
                  main group element atom 19730
                    main group molecular entity 19730
                      s-block molecular entity 19481
                        hydrogen molecular entity 19473
                          hydrides 18743
                            inorganic hydride 17482
                              chalcogen hydride 2445
                                sulfur hydride 2054
                                  hydrogen sulfide 2054
                                    thiol group 1945
                                      thiol 1945
                                        1,4-dimercaptobutane-2,3-diol 89
                                          dithioerythritol 4
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