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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
licochalcone A inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] |
CTD |
PMID:26134484 |
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NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Akt1 |
AKT serine/threonine kinase 1 |
decreases expression |
ISO |
licochalcone A results in decreased expression of AKT1 mRNA |
CTD |
PMID:30055311 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Bad |
BCL2-associated agonist of cell death |
increases expression |
ISO |
licochalcone A results in increased expression of BAD mRNA |
CTD |
PMID:30055311 |
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NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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G |
Bak1 |
BCL2-antagonist/killer 1 |
increases expression |
ISO |
licochalcone A results in increased expression of BAK1 mRNA |
CTD |
PMID:30055311 |
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NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
licochalcone A results in increased expression of BAX mRNA |
CTD |
PMID:30055311 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bbc3 |
Bcl-2 binding component 3 |
increases expression |
ISO |
licochalcone A results in increased expression of BBC3 mRNA |
CTD |
PMID:30055311 |
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NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
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G |
Bcl2 |
BCL2, apoptosis regulator |
increases expression |
ISO |
licochalcone A results in increased expression of BCL2 mRNA |
CTD |
PMID:30055311 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Birc5 |
baculoviral IAP repeat-containing 5 |
decreases expression |
ISO |
licochalcone A results in decreased expression of BIRC5 mRNA |
CTD |
PMID:30055311 |
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NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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G |
Casp3 |
caspase 3 |
increases cleavage increases expression multiple interactions |
ISO |
licochalcone A results in increased cleavage of CASP3 protein licochalcone A results in increased expression of CASP3 mRNA SB 203580 inhibits the reaction [licochalcone A results in increased cleavage of CASP3 protein] |
CTD |
PMID:30055311 PMID:30983163 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
multiple interactions increases cleavage increases expression |
ISO |
SB 203580 inhibits the reaction [licochalcone A results in increased cleavage of CASP8 protein] licochalcone A results in increased expression of CASP8 mRNA |
CTD |
PMID:30055311 PMID:30983163 |
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
increases cleavage multiple interactions |
ISO |
licochalcone A results in increased cleavage of CASP9 protein SB 203580 inhibits the reaction [licochalcone A results in increased cleavage of CASP9 protein] |
CTD |
PMID:30983163 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Ccn1 |
cellular communication network factor 1 |
decreases expression |
ISO |
licochalcone A results in decreased expression of CCN1 mRNA |
CTD |
PMID:34845814 |
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NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
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G |
Ccn2 |
cellular communication network factor 2 |
decreases expression |
ISO |
licochalcone A results in decreased expression of CCN2 mRNA |
CTD |
PMID:34845814 |
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NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
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G |
Ccnb1 |
cyclin B1 |
decreases expression |
ISO |
licochalcone A results in decreased expression of CCNB1 mRNA |
CTD |
PMID:30055311 |
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NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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G |
Ccnd1 |
cyclin D1 |
increases expression |
ISO |
licochalcone A results in increased expression of CCND1 mRNA |
CTD |
PMID:30055311 |
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Cdk1 |
cyclin-dependent kinase 1 |
decreases expression |
ISO |
licochalcone A results in decreased expression of CDK1 mRNA |
CTD |
PMID:30055311 |
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NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
licochalcone A results in increased expression of CDKN1A mRNA |
CTD |
PMID:30055311 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
decreases activity |
ISO |
licochalcone A results in decreased activity of CYP1A2 protein |
CTD |
PMID:26100226 |
|
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
multiple interactions decreases expression |
ISO |
licochalcone A inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CYP1B1 mRNA]; licochalcone A inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA] licochalcone A results in decreased expression of CYP1B1 mRNA |
CTD |
PMID:26134484 |
|
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
decreases activity |
ISO |
licochalcone A results in decreased activity of CYP2C19 protein |
CTD |
PMID:26100226 |
|
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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G |
Cyp2c79 |
cytochrome P450, family 2, subfamily c, polypeptide 79 |
decreases activity |
ISO |
licochalcone A results in decreased activity of CYP2C8 protein |
CTD |
PMID:26100226 |
|
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G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
affects activity |
ISO |
licochalcone A affects the activity of CYP2D6 protein |
CTD |
PMID:26100226 |
|
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
affects activity |
ISO |
licochalcone A affects the activity of CYP2E1 protein |
CTD |
PMID:26100226 |
|
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
decreases activity |
ISO |
licochalcone A results in decreased activity of CYP3A4 protein |
CTD |
PMID:26100226 |
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Dyrk1a |
dual specificity tyrosine phosphorylation regulated kinase 1A |
decreases activity |
ISO |
licochalcone A results in decreased activity of DYRK1A protein |
CTD |
PMID:31838052 |
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NCBI chr11:33,890,706...34,009,420
Ensembl chr11:33,890,490...34,009,420
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G |
Fas |
Fas cell surface death receptor |
increases expression |
ISO |
licochalcone A results in increased expression of FAS mRNA |
CTD |
PMID:30055311 |
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NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
licochalcone A inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CYP1B1 mRNA] |
CTD |
PMID:26134484 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
licochalcone A inhibits the reaction [IL1B protein results in increased abundance of Dinoprost]; licochalcone A inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone] |
CTD |
PMID:16354411 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Lats1 |
large tumor suppressor kinase 1 |
decreases expression increases expression |
ISO |
licochalcone A results in decreased expression of LATS1 protein licochalcone A results in increased expression of LATS1 protein modified form |
CTD |
PMID:34845814 |
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NCBI chr 1:2,160,411...2,193,640
Ensembl chr 1:2,160,411...2,193,640
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G |
Map2k4 |
mitogen activated protein kinase kinase 4 |
decreases phosphorylation multiple interactions |
ISO |
licochalcone A results in decreased phosphorylation of MAP2K4 protein licochalcone A promotes the reaction [Sorafenib results in decreased phosphorylation of MAP2K4 protein]; Sorafenib promotes the reaction [licochalcone A results in decreased phosphorylation of MAP2K4 protein] |
CTD |
PMID:30187994 |
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NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993
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G |
Mapk1 |
mitogen activated protein kinase 1 |
increases phosphorylation |
ISO |
licochalcone A results in increased phosphorylation of MAPK1 protein |
CTD |
PMID:30983163 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
increases phosphorylation |
ISO |
licochalcone A results in increased phosphorylation of MAPK3 protein |
CTD |
PMID:30983163 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions decreases phosphorylation increases expression |
ISO |
licochalcone A promotes the reaction [Sorafenib results in decreased phosphorylation of MAPK8 protein]; Sorafenib promotes the reaction [licochalcone A results in decreased phosphorylation of MAPK8 protein] licochalcone A results in increased expression of MAPK8 mRNA |
CTD |
PMID:30055311 PMID:30187994 |
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NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mapk9 |
mitogen-activated protein kinase 9 |
decreases phosphorylation multiple interactions |
ISO |
licochalcone A results in decreased phosphorylation of MAPK9 protein licochalcone A promotes the reaction [Sorafenib results in decreased phosphorylation of MAPK9 protein]; Sorafenib promotes the reaction [licochalcone A results in decreased phosphorylation of MAPK9 protein] |
CTD |
PMID:30187994 |
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NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
licochalcone A inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] |
CTD |
PMID:26134484 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression |
ISO |
licochalcone A results in increased expression of NQO1 protein |
CTD |
PMID:26473469 |
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage |
ISO |
licochalcone A results in increased cleavage of PARP1 protein |
CTD |
PMID:30983163 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pes1 |
pescadillo ribosomal biogenesis factor 1 |
affects expression multiple interactions decreases expression |
ISO |
licochalcone A affects the expression of PES1 protein modified form licochalcone A results in decreased expression of and affects the localization of PES1 protein licochalcone A results in decreased expression of PES1 mRNA |
CTD |
PMID:34845814 |
|
NCBI chr14:78,850,754...78,867,134
Ensembl chr14:78,850,709...78,867,134
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G |
Plau |
plasminogen activator, urokinase |
multiple interactions decreases expression |
ISO |
licochalcone A promotes the reaction [Sorafenib results in decreased expression of PLAU protein]; Sorafenib promotes the reaction [licochalcone A results in decreased expression of PLAU protein] |
CTD |
PMID:30187994 |
|
NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
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G |
Prkce |
protein kinase C, epsilon |
decreases expression |
ISO |
licochalcone A results in decreased expression of PRKCE mRNA |
CTD |
PMID:30055311 |
|
NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719
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G |
Rps6kb1 |
ribosomal protein S6 kinase B1 |
decreases expression |
ISO |
licochalcone A results in decreased expression of RPS6KB1 mRNA |
CTD |
PMID:30055311 |
|
NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
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G |
Slco1c1 |
solute carrier organic anion transporter family, member 1c1 |
multiple interactions decreases activity |
EXP |
[licochalcone A results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan; [licochalcone A results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Methotrexate |
CTD |
PMID:32259555 |
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NCBI chr 4:174,466,621...174,513,290
Ensembl chr 4:174,466,631...174,513,289
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G |
Stk4 |
serine/threonine kinase 4 |
increases expression multiple interactions decreases expression |
ISO |
licochalcone A results in increased expression of STK4 protein modified form XMU-MP-1 inhibits the reaction [licochalcone A results in increased expression of STK4 protein modified form] licochalcone A results in decreased expression of STK4 protein |
CTD |
PMID:34845814 |
|
NCBI chr 3:152,745,958...152,827,747
Ensembl chr 3:152,745,681...152,827,744
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
licochalcone A inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CYP1B1 mRNA] |
CTD |
PMID:26134484 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tnfrsf25 |
TNF receptor superfamily member 25 |
increases expression |
ISO |
licochalcone A results in increased expression of TNFRSF25 mRNA |
CTD |
PMID:30055311 |
|
NCBI chr 5:162,621,669...162,626,341
Ensembl chr 5:162,622,075...162,626,341
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G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
multiple interactions |
ISO |
licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A1 protein] |
CTD |
PMID:26875642 |
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NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a2 |
UDP glucuronosyltransferase 1 family, polypeptide A2 |
multiple interactions |
ISO |
licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A3 protein] |
CTD |
PMID:26875642 |
|
NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a5 |
UDP glucuronosyltransferase family 1 member A5 |
multiple interactions |
ISO |
licochalcone A inhibits the reaction [Trifluoperazine results in increased activity of UGT1A4 protein] |
CTD |
PMID:26875642 |
|
NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a6 |
UDP glucuronosyltransferase family 1 member A6 |
multiple interactions |
ISO |
licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A6 protein] |
CTD |
PMID:26875642 |
|
NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a9 |
UDP glucuronosyltransferase family 1 member A9 |
multiple interactions |
ISO |
licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A9 protein]; licochalcone A inhibits the reaction [UGT1A9 protein results in increased glucuronidation of Propofol] |
CTD |
PMID:26875642 |
|
NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt2b1 |
UDP glucuronosyltransferase 2 family, polypeptide B1 |
multiple interactions |
ISO |
licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT2B17 protein] |
CTD |
PMID:26875642 |
|
NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
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G |
Ugt2b7 |
UDP glucuronosyltransferase family 2 member B7 |
multiple interactions |
ISO |
licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT2B7 protein] |
CTD |
PMID:26875642 |
|
NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
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G |
Wee1 |
WEE1 G2 checkpoint kinase |
increases expression |
ISO |
licochalcone A results in increased expression of WEE1 mRNA |
CTD |
PMID:30055311 |
|
NCBI chr 1:164,173,681...164,197,688
Ensembl chr 1:164,174,779...164,197,688
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G |
Wwtr1 |
WW domain containing transcription regulator 1 |
decreases expression |
ISO |
licochalcone A results in decreased expression of WWTR1 protein |
CTD |
PMID:34845814 |
|
NCBI chr 2:141,651,159...141,766,919
Ensembl chr 2:141,648,108...141,766,968
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G |
Yap1 |
Yes1 associated transcriptional regulator |
decreases expression multiple interactions |
ISO |
licochalcone A results in decreased expression of YAP1 mRNA; licochalcone A results in decreased expression of YAP1 protein XMU-MP-1 inhibits the reaction [licochalcone A results in increased expression of YAP1 protein modified form] |
CTD |
PMID:34845814 |
|
NCBI chr 8:5,095,705...5,166,808
Ensembl chr 8:5,095,722...5,167,010
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