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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4-nitrophenyl phosphate
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Accession:CHEBI:17440 term browser browse the term
Definition:An aryl phosphate resulting from the mono-esterification of phosphoric acid with 4-nitrophenol.
Synonyms:related_synonym: 4-nitrophenyl dihydrogen phosphate;   Formula=C6H6NO6P;   InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12);   InChIKey=XZKIHKMTEMTJQX-UHFFFAOYSA-N;   SMILES=OP(O)(=O)Oc1ccc(cc1)[N+]([O-])=O;   nitrophenylphosphate;   p-nitrophenyl dihydrogen phosphate;   p-nitrophenyl phosphate;   phosphoric acid, mono(4-nitrophenyl) ester;   phosphoric acid, mono(p-nitrophenyl) ester
 alt_id: CHEBI:12035;   CHEBI:1915;   CHEBI:20458;   CHEBI:40049
 xref: CAS:330-13-2;   DrugBank:DB04214;   HMDB:HMDB0060272;   KEGG:C03360
 xref_mesh: MESH:C008644
 xref: MetaCyc:CPD-194;   PDBeChem:4NP;   PMID:23305417;   Reaxys:1578142;   Wikipedia:Para-Nitrophenylphosphate
 cyclic_relationship: is_conjugate_acid_of CHEBI:61146


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4-nitrophenyl phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp1 acid phosphatase 1 multiple interactions
increases hydrolysis
ISO Benzoic Acid analog inhibits the reaction [ACP1 protein results in increased hydrolysis of nitrophenylphosphate]; Thiazolidines analog inhibits the reaction [ACP1 protein results in increased hydrolysis of nitrophenylphosphate] CTD PMID:24287560 NCBI chr 6:49,836,064...49,851,714
Ensembl chr 6:49,836,075...49,851,714
JBrowse link
G Alpp alkaline phosphatase, placental increases chemical synthesis ISO ALPP protein results in increased chemical synthesis of nitrophenylphosphate CTD PMID:1495895 NCBI chr 9:94,189,961...94,193,054
Ensembl chr 9:94,190,067...94,192,813
JBrowse link
G Dusp23 dual specificity phosphatase 23 decreases phosphorylation
multiple interactions
ISO DUSP23 protein results in decreased phosphorylation of nitrophenylphosphate
Edetic Acid inhibits the reaction [DUSP23 protein results in decreased phosphorylation of nitrophenylphosphate]; Ethylmaleimide inhibits the reaction [DUSP23 protein results in decreased phosphorylation of nitrophenylphosphate]; Vanadates inhibits the reaction [DUSP23 protein results in decreased phosphorylation of nitrophenylphosphate]
CTD PMID:15147733 NCBI chr13:91,018,670...91,019,862
Ensembl chr13:91,018,510...91,020,112
JBrowse link
G Pgp phosphoglycolate phosphatase decreases phosphorylation ISO PGP protein results in decreased phosphorylation of nitrophenylphosphate analog CTD PMID:24338473 NCBI chr10:13,836,105...13,838,731
Ensembl chr10:13,836,128...13,838,765
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 multiple interactions
increases hydrolysis
ISO Benzoic Acid analog inhibits the reaction [PTPN1 protein results in increased hydrolysis of nitrophenylphosphate]; Thiazolidines analog inhibits the reaction [PTPN1 protein results in increased hydrolysis of nitrophenylphosphate] CTD PMID:24287560 NCBI chr 3:164,665,462...164,711,936
Ensembl chr 3:164,665,532...164,711,848
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 increases hydrolysis
multiple interactions
ISO PTPN2 protein results in increased hydrolysis of nitrophenylphosphate
Benzoic Acid analog inhibits the reaction [PTPN2 protein results in increased hydrolysis of nitrophenylphosphate]; Thiazolidines analog inhibits the reaction [PTPN2 protein results in increased hydrolysis of nitrophenylphosphate]
CTD PMID:24287560 NCBI chr18:63,415,298...63,489,240
Ensembl chr18:63,415,306...63,488,027
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        biochemical role 19281
          metabolite 19262
            xenobiotic metabolite 14041
              human xenobiotic metabolite 13294
                4-nitrophenol 824
                  4-nitrophenyl phosphate 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      chalcogen 19360
                        oxygen atom 19321
                          oxygen molecular entity 19321
                            hydroxides 19066
                              oxoacid 18192
                                pnictogen oxoacid 10144
                                  phosphorus oxoacid 9032
                                    phosphoric acids 7794
                                      phosphoric acid 7794
                                        phosphoric acid derivative 7473
                                          phosphate 7473
                                            organic phosphate 7472
                                              aryl phosphate 1157
                                                4-nitrophenyl phosphate 6
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