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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:naphthalene-1,2-diol
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Accession:CHEBI:17435 term browser browse the term
Definition:A naphthalenediol that has formula C10H8O2.
Synonyms:related_synonym: 1,2-Dihydroxynaphthalene;   1,2-Naphthalenediol;   1,2-naphthohydroquinone;   Formula=C10H8O2;   InChI=1S/C10H8O2/c11-9-6-5-7-3-1-2-4-8(7)10(9)12/h1-6,11-12H;   InChIKey=NXPPAOGUKPJVDI-UHFFFAOYSA-N;   SMILES=Oc1ccc2ccccc2c1O;   beta-Naphthohydroquinone
 alt_id: CHEBI:14639;   CHEBI:18895;   CHEBI:49554;   CHEBI:7473
 xref: Beilstein:1908498;   CAS:574-00-5;   DrugBank:DB07610;   Gmelin:241000;   KEGG:C03012
 xref_mesh: MESH:C050642
 xref: UM-BBD_compID:c0129



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naphthalene-1,2-diol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [1,2-dihydroxynaphthalene analog results in increased activity of NFE2L2 protein] CTD PMID:25807370 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO 1,2-dihydroxynaphthalene analog results in increased expression of GCLC mRNA CTD PMID:25807370 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO 1,2-dihydroxynaphthalene analog results in increased expression of HMOX1 mRNA; 1,2-dihydroxynaphthalene analog results in increased expression of HMOX1 protein CTD PMID:25807370 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 increases metabolic processing
multiple interactions
ISO 1,2-dihydroxynaphthalene analog results in increased metabolism of KEAP1 protein
Glutathione inhibits the reaction [1,2-dihydroxynaphthalene analog results in increased metabolism of KEAP1 protein]
CTD PMID:25807370 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases activity
ISO Buthionine Sulfoximine promotes the reaction [1,2-dihydroxynaphthalene analog results in increased activity of NFE2L2 protein]; CAT protein inhibits the reaction [1,2-dihydroxynaphthalene analog results in increased activity of NFE2L2 protein] CTD PMID:25807370 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO 1,2-dihydroxynaphthalene analog results in increased expression of SLC7A11 mRNA; 1,2-dihydroxynaphthalene analog results in increased expression of SLC7A11 protein CTD PMID:25807370 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Top2a DNA topoisomerase II alpha affects activity ISO 1,2-dihydroxynaphthalene affects the activity of TOP2A protein CTD PMID:33760604 NCBI chr10:83,946,186...83,975,694
Ensembl chr10:83,945,735...83,976,874
JBrowse link
G Top2b DNA topoisomerase II beta affects activity ISO 1,2-dihydroxynaphthalene affects the activity of TOP2B protein CTD PMID:33760604 NCBI chr15:9,051,661...9,111,220
Ensembl chr15:9,051,341...9,112,085
JBrowse link
1,2-dihydronaphthalene-1,2-diol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ephx1 epoxide hydrolase 1 multiple interactions ISO [EPHX1 protein results in increased metabolism of naphthalene] which results in increased chemical synthesis of 1,2-dihydroxy-1,2-dihydronaphthalene CTD PMID:18363382 PMID:26840748 NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      biological role 19751
        biochemical role 19368
          metabolite 19344
            eukaryotic metabolite 19033
              animal metabolite 18895
                mammalian metabolite 18895
                  mouse metabolite 18570
                    naphthalene-1,2-diol 9
                      1,2-dihydronaphthalene-1,2-diol + 1
                      1,2-dihydroxynaphthalene-6-sulfonate 0
                      6-amino-1,2-dihydroxynaphthalene 0
                      8-methylnaphthalene-1,2-diol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic molecule 19549
                              organic cyclic compound 19343
                                carbocyclic compound 18316
                                  carbopolycyclic compound 17029
                                    carbobicyclic compound 5822
                                      naphthalenes 3766
                                        hydroxynaphthalene 255
                                          naphthalenediols 14
                                            naphthalenediol 10
                                              naphthalene-1,2-diol 9
                                                1,2-dihydronaphthalene-1,2-diol + 1
                                                1,2-dihydroxynaphthalene-6-sulfonate 0
                                                6-amino-1,2-dihydroxynaphthalene 0
                                                8-methylnaphthalene-1,2-diol 0
paths to the root