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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:naphthalene-1,2-diol
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Accession:CHEBI:17435 term browser browse the term
Definition:A naphthalenediol that has formula C10H8O2.
Synonyms:related_synonym: 1,2-Dihydroxynaphthalene;   1,2-Naphthalenediol;   1,2-naphthohydroquinone;   Formula=C10H8O2;   InChI=1S/C10H8O2/c11-9-6-5-7-3-1-2-4-8(7)10(9)12/h1-6,11-12H;   InChIKey=NXPPAOGUKPJVDI-UHFFFAOYSA-N;   SMILES=Oc1ccc2ccccc2c1O;   beta-Naphthohydroquinone
 alt_id: CHEBI:14639;   CHEBI:18895;   CHEBI:49554;   CHEBI:7473
 xref: Beilstein:1908498;   CAS:574-00-5;   DrugBank:DB07610;   Gmelin:241000;   KEGG:C03012
 xref_mesh: MESH:C050642
 xref: UM-BBD_compID:c0129


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naphthalene-1,2-diol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [1,2-dihydroxynaphthalene analog results in increased activity of NFE2L2 protein] CTD PMID:25807370 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO 1,2-dihydroxynaphthalene analog results in increased expression of GCLC mRNA CTD PMID:25807370 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO 1,2-dihydroxynaphthalene analog results in increased expression of HMOX1 mRNA; 1,2-dihydroxynaphthalene analog results in increased expression of HMOX1 protein CTD PMID:25807370 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 increases metabolic processing
multiple interactions
ISO 1,2-dihydroxynaphthalene analog results in increased metabolism of KEAP1 protein
Glutathione inhibits the reaction [1,2-dihydroxynaphthalene analog results in increased metabolism of KEAP1 protein]
CTD PMID:25807370 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases activity
ISO Buthionine Sulfoximine promotes the reaction [1,2-dihydroxynaphthalene analog results in increased activity of NFE2L2 protein]; CAT protein inhibits the reaction [1,2-dihydroxynaphthalene analog results in increased activity of NFE2L2 protein] CTD PMID:25807370 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO 1,2-dihydroxynaphthalene analog results in increased expression of SLC7A11 mRNA; 1,2-dihydroxynaphthalene analog results in increased expression of SLC7A11 protein CTD PMID:25807370 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
1,2-dihydronaphthalene-1,2-diol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ephx1 epoxide hydrolase 1 multiple interactions ISO [EPHX1 protein results in increased metabolism of naphthalene] which results in increased chemical synthesis of 1,2-dihydroxy-1,2-dihydronaphthalene CTD PMID:18363382, PMID:26840748 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        biochemical role 19313
          metabolite 19294
            eukaryotic metabolite 18943
              animal metabolite 18747
                mammalian metabolite 18746
                  mouse metabolite 18410
                    naphthalene-1,2-diol 7
                      1,2-dihydronaphthalene-1,2-diol + 1
                      1,2-dihydroxynaphthalene-6-sulfonate 0
                      6-amino-1,2-dihydroxynaphthalene 0
                      8-methylnaphthalene-1,2-diol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                carbocyclic compound 18222
                                  carbopolycyclic compound 16971
                                    carbobicyclic compound 4561
                                      naphthalenes 3744
                                        hydroxynaphthalene 243
                                          naphthalenediols 12
                                            naphthalenediol 8
                                              naphthalene-1,2-diol 7
                                                1,2-dihydronaphthalene-1,2-diol + 1
                                                1,2-dihydroxynaphthalene-6-sulfonate 0
                                                6-amino-1,2-dihydroxynaphthalene 0
                                                8-methylnaphthalene-1,2-diol 0
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