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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:agmatine
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Accession:CHEBI:17431 term browser browse the term
Definition:A guanidine that has formula C5H14N4.
Synonyms:related_synonym: (4-aminobutyl)guanidine;   1-(4-aminobutyl)guanidine;   Formula=C5H14N4;   InChI=1S/C5H14N4/c6-3-1-2-4-9-5(7)8/h1-4,6H2,(H4,7,8,9);   InChIKey=QYPPJABKJHAVHS-UHFFFAOYSA-N;   N-(4-aminobutyl)guanidine;   SMILES=NCCCCNC(N)=N
 alt_id: CHEBI:13747;   CHEBI:18576;   CHEBI:2514;   CHEBI:40556
 xref: CAS:306-60-5;   KEGG:C00179;   KNApSAcK:C00001400
 xref_mesh: MESH:D000376
 cyclic_relationship: is_conjugate_base_of CHEBI:58145


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agmatine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein decreases abundance
multiple interactions
ISO APP protein results in decreased abundance of Agmatine
Agmatine inhibits the reaction [APP protein results in decreased expression of BDNF protein]; Agmatine inhibits the reaction [APP protein results in decreased expression of MME protein]; Agmatine inhibits the reaction [APP protein results in increased expression of IL6 protein]; Agmatine inhibits the reaction [APP protein results in increased expression of MAPT protein]; Agmatine inhibits the reaction [APP protein results in increased expression of TNF protein]
CTD PMID:32522471 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO Agmatine inhibits the reaction [APP protein results in decreased expression of BDNF protein] CTD PMID:32522471 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Agmatine inhibits the reaction [Morphine results in increased expression of FOSB protein] CTD PMID:15899480 NCBI chr 1:80,214,691...80,221,417
Ensembl chr 1:80,214,494...80,221,710
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO Agmatine inhibits the reaction [MBP protein results in increased expression of GFAP protein]; NOS2 gene mutant form promotes the reaction [Agmatine inhibits the reaction [MBP protein results in increased expression of GFAP protein]] CTD PMID:24070732 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions EXP Agmatine inhibits the reaction [Morphine results in increased expression of GRIN1 protein] CTD PMID:20950603 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Agmatine inhibits the reaction [APP protein results in increased expression of IL6 protein]; Agmatine inhibits the reaction [Valproic Acid results in increased expression of IL6 protein] CTD PMID:30273971, PMID:32522471 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO Agmatine inhibits the reaction [APP protein results in increased expression of MAPT protein] CTD PMID:32522471 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Mbp myelin basic protein multiple interactions ISO Agmatine inhibits the reaction [MBP protein results in increased expression of GFAP protein]; Agmatine inhibits the reaction [MBP protein results in increased expression of TFRC protein]; NOS2 gene mutant form promotes the reaction [Agmatine inhibits the reaction [MBP protein results in increased expression of GFAP protein]] CTD PMID:24070732 NCBI chr18:79,326,738...79,437,310
Ensembl chr18:79,326,738...79,437,310
JBrowse link
G Mme membrane metallo-endopeptidase multiple interactions ISO Agmatine inhibits the reaction [APP protein results in decreased expression of MME protein] CTD PMID:32522471 NCBI chr 2:153,799,203...153,880,910
Ensembl chr 2:153,803,349...153,880,738
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Agmatine inhibits the reaction [Valproic Acid results in increased expression of NOS2 protein]; NOS2 gene mutant form promotes the reaction [Agmatine inhibits the reaction [MBP protein results in increased expression of GFAP protein]] CTD PMID:24070732, PMID:30273971 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Agmatine inhibits the reaction [Valproic Acid results in increased expression of RELA protein] CTD PMID:30273971 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Agmatine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,631,425...47,685,379
Ensembl chr10:47,632,192...47,666,921
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Agmatine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,587,909...47,631,373
Ensembl chr10:47,588,497...47,630,799
JBrowse link
G Tfrc transferrin receptor multiple interactions ISO Agmatine inhibits the reaction [MBP protein results in increased expression of TFRC protein] CTD PMID:24070732 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP Agmatine inhibits the reaction [Morphine results in increased expression of TH protein] CTD PMID:15541421 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Agmatine inhibits the reaction [APP protein results in increased expression of TNF protein]; Agmatine inhibits the reaction [Valproic Acid results in increased expression of TNF protein] CTD PMID:30273971, PMID:32522471 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        refrigerant 17418
          ammonia 16939
            organic amino compound 16938
              primary amino compound 7858
                agmatine 16
                  N(1)-aminoaminopropylagmatine 0
                  N(4)-phosphoagmatine 0
                  acetylagmatine 0
                  agmatidine 0
                  alpha-allenylagmatine 0
                  feruloylagmatine + 0
                  p-coumaroylagmatine + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    main group molecular entity 19670
                      s-block molecular entity 19428
                        hydrogen molecular entity 19418
                          hydrides 18685
                            inorganic hydride 17409
                              pnictogen hydride 17381
                                nitrogen hydride 17223
                                  azane 16940
                                    ammonia 16939
                                      organic amino compound 16938
                                        primary amino compound 7858
                                          agmatine 16
                                            N(1)-aminoaminopropylagmatine 0
                                            N(4)-phosphoagmatine 0
                                            acetylagmatine 0
                                            agmatidine 0
                                            alpha-allenylagmatine 0
                                            feruloylagmatine + 0
                                            p-coumaroylagmatine + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.