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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:agmatine
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Accession:CHEBI:17431 term browser browse the term
Definition:A guanidine that has formula C5H14N4.
Synonyms:related_synonym: (4-aminobutyl)guanidine;   1-(4-aminobutyl)guanidine;   Formula=C5H14N4;   InChI=1S/C5H14N4/c6-3-1-2-4-9-5(7)8/h1-4,6H2,(H4,7,8,9);   InChIKey=QYPPJABKJHAVHS-UHFFFAOYSA-N;   N-(4-aminobutyl)guanidine;   SMILES=NCCCCNC(N)=N
 alt_id: CHEBI:13747;   CHEBI:18576;   CHEBI:2514;   CHEBI:40556
 xref: CAS:306-60-5;   KEGG:C00179;   KNApSAcK:C00001400
 xref_mesh: MESH:D000376
 cyclic_relationship: is_conjugate_base_of CHEBI:58145



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agmatine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein decreases abundance
multiple interactions
ISO APP protein results in decreased abundance of Agmatine
Agmatine inhibits the reaction [APP protein results in decreased expression of BDNF protein]; Agmatine inhibits the reaction [APP protein results in decreased expression of MME protein]; Agmatine inhibits the reaction [APP protein results in increased expression of IL6 protein]; Agmatine inhibits the reaction [APP protein results in increased expression of MAPT protein]; Agmatine inhibits the reaction [APP protein results in increased expression of TNF protein]
CTD PMID:32522471 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO Agmatine inhibits the reaction [APP protein results in decreased expression of BDNF protein] CTD PMID:32522471 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Agmatine inhibits the reaction [Morphine results in increased expression of FOSB protein] CTD PMID:15899480 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO Agmatine inhibits the reaction [MBP protein results in increased expression of GFAP protein]; NOS2 gene mutant form promotes the reaction [Agmatine inhibits the reaction [MBP protein results in increased expression of GFAP protein]] CTD PMID:24070732 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions EXP Agmatine inhibits the reaction [Morphine results in increased expression of GRIN1 protein] CTD PMID:20950603 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Agmatine inhibits the reaction [APP protein results in increased expression of IL6 protein]; Agmatine inhibits the reaction [Valproic Acid results in increased expression of IL6 protein] CTD PMID:30273971 PMID:32522471 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO Agmatine inhibits the reaction [APP protein results in increased expression of MAPT protein] CTD PMID:32522471 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Mbp myelin basic protein multiple interactions ISO Agmatine inhibits the reaction [MBP protein results in increased expression of GFAP protein]; Agmatine inhibits the reaction [MBP protein results in increased expression of TFRC protein]; NOS2 gene mutant form promotes the reaction [Agmatine inhibits the reaction [MBP protein results in increased expression of GFAP protein]] CTD PMID:24070732 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404
JBrowse link
G Mme membrane metallo-endopeptidase multiple interactions ISO Agmatine inhibits the reaction [APP protein results in decreased expression of MME protein] CTD PMID:32522471 NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Agmatine inhibits the reaction [Valproic Acid results in increased expression of NOS2 protein]; NOS2 gene mutant form promotes the reaction [Agmatine inhibits the reaction [MBP protein results in increased expression of GFAP protein]] CTD PMID:24070732 PMID:30273971 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Agmatine inhibits the reaction [Valproic Acid results in increased expression of RELA protein] CTD PMID:30273971 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Agmatine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Agmatine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
JBrowse link
G Tfrc transferrin receptor multiple interactions ISO Agmatine inhibits the reaction [MBP protein results in increased expression of TFRC protein] CTD PMID:24070732 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP Agmatine inhibits the reaction [Morphine results in increased expression of TH protein] CTD PMID:15541421 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Agmatine inhibits the reaction [APP protein results in increased expression of TNF protein]; Agmatine inhibits the reaction [Valproic Acid results in increased expression of TNF protein] CTD PMID:30273971 PMID:32522471 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19763
      application 19477
        refrigerant 17699
          ammonia 17288
            organic amino compound 17288
              primary amino compound 7981
                agmatine 16
                  N(1)-aminoaminopropylagmatine 0
                  N(4)-phosphoagmatine 0
                  acetylagmatine 0
                  agmatidine 0
                  alpha-allenylagmatine 0
                  feruloylagmatine + 0
                  p-coumaroylagmatine + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19710
                    main group molecular entity 19710
                      s-block molecular entity 19492
                        hydrogen molecular entity 19484
                          hydrides 18850
                            inorganic hydride 17700
                              pnictogen hydride 17681
                                nitrogen hydride 17552
                                  azane 17289
                                    ammonia 17288
                                      organic amino compound 17288
                                        primary amino compound 7981
                                          agmatine 16
                                            N(1)-aminoaminopropylagmatine 0
                                            N(4)-phosphoagmatine 0
                                            acetylagmatine 0
                                            agmatidine 0
                                            alpha-allenylagmatine 0
                                            feruloylagmatine + 0
                                            p-coumaroylagmatine + 0
paths to the root