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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:P(1),P(4)-bis(5'-adenosyl) tetraphosphate
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Accession:CHEBI:17422 term browser browse the term
Definition:A diadenosyl tetraphosphate compound having the two 5'-adenosyl residues attached at the P(1)- and P(4)-positions.
Synonyms:related_synonym: (ppA)2;   A(5')p4(5')A;   Adenosine-(5')-tetraphospho-(5')-adenosine;   AppppA;   Formula=C20H28N10O19P4;   InChI=1S/C20H28N10O19P4/c21-15-9-17(25-3-23-15)29(5-27-9)19-13(33)11(31)7(45-19)1-43-50(35,36)47-52(39,40)49-53(41,42)48-51(37,38)44-2-8-12(32)14(34)20(46-8)30-6-28-10-16(22)24-4-26-18(10)30/h3-8,11-14,19-20,31-34H,1-2H2,(H,35,36)(H,37,38)(H,39,40)(H,41,42)(H2,21,23,25)(H2,22,24,26)/t7-,8-,11-,12-,13-,14-,19-,20-/m1/s1;   InChIKey=YOAHKNVSNCMZGQ-XPWFQUROSA-N;   P1,P4-Bis(5'-adenosyl) tetraphosphate;   SMILES=Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O;   bis(5'-adenylyl) diphosphate
 alt_id: CHEBI:12726;   CHEBI:12729;   CHEBI:21998;   CHEBI:7875
 xref: KEGG:C01260
 xref_mesh: MESH:C020733
 xref: PDBeChem:B4P
 cyclic_relationship: is_conjugate_acid_of CHEBI:58141


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P(1),P(4)-bis(5'-adenosyl) tetraphosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions EXP diadenosine tetraphosphate inhibits the reaction [Methamphetamine results in increased cleavage of CASP3 protein] CTD PMID:19442829 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Nudt10 nudix hydrolase 10 increases metabolic processing ISO NUDT10 protein results in increased metabolism of diadenosine tetraphosphate CTD PMID:12121577
G Nudt2 nudix hydrolase 2 increases hydrolysis ISO NUDT2 protein results in increased hydrolysis of diadenosine tetraphosphate CTD PMID:20533549 NCBI chr 5:56,628,265...56,643,104
Ensembl chr 5:56,628,265...56,643,104
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP diadenosine tetraphosphate inhibits the reaction [Methamphetamine results in decreased expression of TH protein] CTD PMID:19442829 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link

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  CHEBI ontology 19812
    role 19761
      biological role 19761
        pharmacological role 18842
          analgesic 13302
            adenosine 350
              diadenosyl tetraphosphate 4
                P(1),P(4)-bis(5'-adenosyl) tetraphosphate 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            heteroorganic entity 19283
                              organochalcogen compound 19054
                                organooxygen compound 19004
                                  carbohydrates and carbohydrate derivatives 12341
                                    carbohydrate 12341
                                      carbohydrate derivative 11945
                                        glycosyl compound 10978
                                          N-glycosyl compound 5515
                                            nucleoside 5376
                                              ribonucleoside 674
                                                purine ribonucleoside 568
                                                  purines D-ribonucleoside 358
                                                    adenosine 350
                                                      diadenosyl tetraphosphate 4
                                                        P(1),P(4)-bis(5'-adenosyl) tetraphosphate 4
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