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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:P(1),P(4)-bis(5'-adenosyl) tetraphosphate
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Accession:CHEBI:17422 term browser browse the term
Definition:A diadenosyl tetraphosphate compound having the two 5'-adenosyl residues attached at the P(1)- and P(4)-positions.
Synonyms:related_synonym: (ppA)2;   A(5')p4(5')A;   Adenosine-(5')-tetraphospho-(5')-adenosine;   AppppA;   Formula=C20H28N10O19P4;   InChI=1S/C20H28N10O19P4/c21-15-9-17(25-3-23-15)29(5-27-9)19-13(33)11(31)7(45-19)1-43-50(35,36)47-52(39,40)49-53(41,42)48-51(37,38)44-2-8-12(32)14(34)20(46-8)30-6-28-10-16(22)24-4-26-18(10)30/h3-8,11-14,19-20,31-34H,1-2H2,(H,35,36)(H,37,38)(H,39,40)(H,41,42)(H2,21,23,25)(H2,22,24,26)/t7-,8-,11-,12-,13-,14-,19-,20-/m1/s1;   InChIKey=YOAHKNVSNCMZGQ-XPWFQUROSA-N;   P1,P4-Bis(5'-adenosyl) tetraphosphate;   SMILES=Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O;   bis(5'-adenylyl) diphosphate
 alt_id: CHEBI:12726;   CHEBI:12729;   CHEBI:21998;   CHEBI:7875
 xref: KEGG:C01260
 xref_mesh: MESH:C020733
 xref: PDBeChem:B4P
 cyclic_relationship: is_conjugate_acid_of CHEBI:58141


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P(1),P(4)-bis(5'-adenosyl) tetraphosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions EXP diadenosine tetraphosphate inhibits the reaction [Methamphetamine results in increased cleavage of CASP3 protein] CTD PMID:19442829 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Nudt2 nudix hydrolase 2 increases hydrolysis ISO NUDT2 protein results in increased hydrolysis of diadenosine tetraphosphate CTD PMID:20533549 NCBI chr 5:61,424,176...61,439,018
Ensembl chr 5:61,424,053...61,439,015 		JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP diadenosine tetraphosphate inhibits the reaction [Methamphetamine results in decreased expression of TH protein] CTD PMID:19442829 NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20841
    role 20801
      biological role 20799
        pharmacological role 19912
          analgesic 14887
            adenosine 414
              diadenosyl tetraphosphate 3
                P(1),P(4)-bis(5'-adenosyl) tetraphosphate 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 20841
    subatomic particle 20839
      composite particle 20839
        hadron 20839
          baryon 20839
            nucleon 20839
              atomic nucleus 20839
                atom 20839
                  main group element atom 20762
                    p-block element atom 20786
                      carbon group element atom 20695
                        carbon atom 20690
                          organic molecular entity 20690
                            heteroorganic entity 20202
                              organochalcogen compound 19889
                                organooxygen compound 19791
                                  carbohydrates and carbohydrate derivatives 15420
                                    carbohydrate 15420
                                      carbohydrate derivative 14439
                                        glycosyl compound 13147
                                          N-glycosyl compound 5894
                                            nucleoside 5748
                                              ribonucleoside 1158
                                                purine ribonucleoside 827
                                                  purines D-ribonucleoside 427
                                                    adenosine 414
                                                      diadenosyl tetraphosphate 3
                                                        P(1),P(4)-bis(5'-adenosyl) tetraphosphate 3
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