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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:myo-inositol hexakisphosphate
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Accession:CHEBI:17401 term browser browse the term
Definition:A myo-inositol hexakisphosphate in which each hydroxy group of myo-inositol is monophosphorylated.
Synonyms:exact_synonym: myo-inositol hexakis(dihydrogen phosphate)
 related_synonym: 1D-myo-Inositol 1,2,3,4,5,6-hexakisphosphate;   1D-myo-Inositol hexakisphosphate;   D-myo-Inositol 1,2,3,4,5,6-hexakisphosphate;   Formula=C6H18O24P6;   InChI=1S/C6H18O24P6/c7-31(8,9)25-1-2(26-32(10,11)12)4(28-34(16,17)18)6(30-36(22,23)24)5(29-35(19,20)21)3(1)27-33(13,14)15/h1-6H,(H2,7,8,9)(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)(H2,19,20,21)(H2,22,23,24)/t1-,2-,3-,4+,5-,6-;   InChIKey=IMQLKJBTEOYOSI-GPIVLXJGSA-N;   Inosithexaphosphorsaeure;   Phytate;   Phytic acid;   Phytine;   SMILES=OP(O)(=O)O[C@@H]1[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H]1OP(O)(O)=O;   Saeure des phytins;   acide fytique;   acido fitico;   acidum fyticum;   myo-inositol 1,2,3,4,5,6-hexakisphosphate
 alt_id: CHEBI:10603;   CHEBI:11366;   CHEBI:12829;   CHEBI:12832;   CHEBI:19200
 xref: Beilstein:2201952;   CAS:83-86-3;   Drug_Central:3465;   KEGG:C01204
 xref_mesh: MESH:D010833
 xref: MetaCyc:HEXAKISPHOSPHATE;   PMID:11217149;   PMID:11545369;   PMID:12070948;   PMID:12162428;   PMID:12816787;   PMID:12949395;   PMID:15325752;   PMID:15743020;   PMID:15918884;   PMID:15952339;   PMID:15998131;   PMID:16438310;   PMID:17162330;   PMID:18536177;   PMID:19331859;   PMID:21292245;   PMID:22023391;   PMID:6095072;   Reaxys:2201952;   Wikipedia:Phytic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:58130


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myo-inositol hexakisphosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases activity ISO Phytic Acid results in decreased activity of AKT1 protein CTD PMID:15868430 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO Phytic Acid inhibits the reaction [Asbestos, Amosite results in increased activity of CASP3 protein] CTD PMID:11329530 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO Phytic Acid inhibits the reaction [Asbestos, Amosite results in increased activity of CASP9 protein] CTD PMID:12540492 PMID:14766669 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions EXP [Phytic Acid co-treated with Inositol] inhibits the reaction [Streptozocin results in decreased activity of CAT protein] CTD PMID:28757134 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Phytic Acid inhibits the reaction [Urethane results in increased expression of CCND1 mRNA]; Phytic Acid inhibits the reaction [Urethane results in increased expression of CCND1 protein] CTD PMID:22797328 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression ISO Phytic Acid results in decreased expression of CDKN1B protein CTD PMID:15868430 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions
affects methylation		 ISO Phytic Acid inhibits the reaction [Ethylnitrosourea results in decreased expression of CDKN2A]
Phytic Acid affects the methylation of CDKN2A promoter		 CTD PMID:21154115 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Phytic Acid inhibits the reaction [Asbestos, Crocidolite results in decreased phosphorylation of EGFR protein] CTD PMID:15626777 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Ehmt2 euchromatic histone lysine methyltransferase 2 multiple interactions ISO Phytic Acid inhibits the reaction [Urethane results in increased expression of EHMT2 mRNA]; Phytic Acid inhibits the reaction [Urethane results in increased expression of EHMT2 protein] CTD PMID:25168426 NCBI chr20:3,919,623...3,936,751
Ensembl chr20:3,919,624...3,941,547 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit multiple interactions ISO Phytic Acid inhibits the reaction [Urethane results in increased expression of EZH2 mRNA]; Phytic Acid inhibits the reaction [Urethane results in increased expression of EZH2 protein] CTD PMID:25168426 NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362 		JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO [resveratrol co-treated with Quercetin co-treated with Phytic Acid] results in increased expression of FOXO1 mRNA CTD PMID:18657603 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions EXP [Phytic Acid co-treated with Inositol] inhibits the reaction [Streptozocin results in decreased activity of G6PD protein] CTD PMID:28757134 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Phytic Acid inhibits the reaction [Urethane results in increased expression of IL6 mRNA]; Phytic Acid inhibits the reaction [Urethane results in increased expression of IL6 protein] CTD PMID:22797328 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases activity
multiple interactions		 ISO
EXP		 Phytic Acid results in decreased activity of MAPK1 protein
[resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased phosphorylation of MAPK1 protein		 CTD PMID:15868430 PMID:21203465 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases activity
multiple interactions		 ISO
EXP		 Phytic Acid results in decreased activity of MAPK3 protein
[resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased phosphorylation of MAPK3 protein		 CTD PMID:15868430 PMID:21203465 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mir101a microRNA 101a multiple interactions EXP [resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR101A mRNA CTD PMID:21203465 NCBI chr 5:115,966,332...115,966,406
Ensembl chr 5:115,966,328...115,966,410 		JBrowse link
G Mir10a microRNA 10a multiple interactions EXP [resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR10A mRNA CTD PMID:21203465 NCBI chr10:81,283,171...81,283,280
Ensembl chr10:81,283,171...81,283,280 		JBrowse link
G Mir138-1 microRNA 138-1 multiple interactions ISO Phytic Acid inhibits the reaction [Urethane results in decreased expression of MIR138-1 mRNA] CTD PMID:25168426 NCBI chr 8:122,300,966...122,301,064
Ensembl chr 8:122,300,966...122,301,064 		JBrowse link
G Mir181c microRNA 181c multiple interactions EXP [resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR181C mRNA CTD PMID:21203465 NCBI chr19:23,983,523...23,983,628
Ensembl chr19:23,983,523...23,983,628 		JBrowse link
G Mir20b microRNA 20b multiple interactions EXP [resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in decreased expression of MIR20B mRNA CTD PMID:21203465 NCBI chr  X:132,422,211...132,422,282
Ensembl chr  X:132,422,211...132,422,282 		JBrowse link
G Mir21 microRNA 21 multiple interactions EXP [resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR21 mRNA CTD PMID:21203465 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mir214 microRNA 214 multiple interactions EXP [Resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR214 mRNA CTD PMID:21203465 NCBI chr13:74,588,374...74,588,481
Ensembl chr13:74,588,372...74,588,481 		JBrowse link
G Mir25 microRNA 25 multiple interactions EXP [resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR25 mRNA CTD PMID:21203465 NCBI chr12:17,042,932...17,043,015
Ensembl chr12:17,042,932...17,043,015 		JBrowse link
G Mir27b microRNA 27b multiple interactions EXP [resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in decreased expression of MIR27B mRNA CTD PMID:21203465 NCBI chr17:1,813,427...1,813,523
Ensembl chr17:1,813,426...1,813,529 		JBrowse link
G Mir324 microRNA 324 multiple interactions EXP [resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR324 mRNA CTD PMID:21203465 NCBI chr10:54,734,680...54,734,762
Ensembl chr10:54,734,678...54,734,766 		JBrowse link
G Mir339 microRNA 339 multiple interactions EXP [resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR339 mRNA CTD PMID:21203465 NCBI chr12:15,277,546...15,277,641
Ensembl chr12:15,277,546...15,277,641 		JBrowse link
G Mir450a1 microRNA 450a-1 multiple interactions EXP [resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR450A1 mRNA CTD PMID:21203465 NCBI chr  X:132,801,380...132,801,470
Ensembl chr  X:132,801,380...132,801,470 		JBrowse link
G Mir760 microRNA 760 multiple interactions EXP [resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR760 mRNA CTD PMID:21203465 NCBI chr 2:210,392,616...210,392,695
Ensembl chr 2:210,392,616...210,392,695 		JBrowse link
G Mlh1 mutL homolog 1 multiple interactions
affects methylation		 ISO Phytic Acid inhibits the reaction [Ethylnitrosourea results in increased expression of MLH1]
Phytic Acid affects the methylation of MLH1 promoter		 CTD PMID:21154115 NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Phytic Acid inhibits the reaction [Urethane results in decreased expression of NFKB1 mRNA]; Phytic Acid inhibits the reaction [Urethane results in decreased expression of NFKB1 protein]; Phytic Acid inhibits the reaction [Urethane results in increased expression of NFKB1 mRNA]; Phytic Acid inhibits the reaction [Urethane results in increased expression of NFKB1 protein] CTD PMID:22797328 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Phytic Acid inhibits the reaction [Asbestos, Amosite results in increased activity of PARP1 protein]; Phytic Acid inhibits the reaction [Smoke analog results in increased activity of PARP1 protein] CTD PMID:11217149 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 multiple interactions ISO [resveratrol co-treated with Quercetin co-treated with Phytic Acid] results in increased expression of PDK4 mRNA CTD PMID:18657603 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO [resveratrol co-treated with Quercetin co-treated with Phytic Acid] results in increased expression of PPARGC1A mRNA CTD PMID:18657603 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO Phytic Acid results in increased expression of and results in increased activity of and affects the localization of PRKCD protein CTD PMID:15868430 NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
affects methylation		 ISO Phytic Acid inhibits the reaction [Ethylnitrosourea results in increased expression of PTGS2]; Phytic Acid inhibits the reaction [Urethane results in increased expression of PTGS2 mRNA]; Phytic Acid inhibits the reaction [Urethane results in increased expression of PTGS2 protein]
Phytic Acid affects the methylation of PTGS2 promoter		 CTD PMID:21154115 PMID:22797328 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO Phytic Acid results in decreased phosphorylation of RB1 protein CTD PMID:15868430 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Phytic Acid inhibits the reaction [Urethane results in increased expression of RELA mRNA]; Phytic Acid inhibits the reaction [Urethane results in increased expression of RELA protein] CTD PMID:22797328 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Phytic Acid inhibits the reaction [Urethane results in increased expression of and results in increased phosphorylation of STAT3 protein]; Phytic Acid inhibits the reaction [Urethane results in increased expression of STAT3 mRNA] CTD PMID:22797328 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Suv39h1 SUV39H1 histone lysine methyltransferase multiple interactions ISO Phytic Acid inhibits the reaction [Urethane results in increased expression of SUV39H1 mRNA]; Phytic Acid inhibits the reaction [Urethane results in increased expression of SUV39H1 protein] CTD PMID:25168426 NCBI chr  X:14,421,028...14,433,993
Ensembl chr  X:14,421,109...14,433,982 		JBrowse link
G Suv39h1-ps1 SUV39H1 histone lysine methyltransferase, pseudogene 1 multiple interactions ISO Phytic Acid inhibits the reaction [Urethane results in increased expression of SUV39H1 mRNA]; Phytic Acid inhibits the reaction [Urethane results in increased expression of SUV39H1 protein] CTD PMID:25168426 NCBI chr  X:141,792,589...141,795,257 JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO
EXP		 Phytic Acid inhibits the reaction [Asbestos, Amosite results in increased expression of TP53 mRNA]; Phytic Acid inhibits the reaction [Asbestos, Amosite results in increased expression of TP53 protein] CTD PMID:16357363 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Ucp3 uncoupling protein 3 multiple interactions ISO [resveratrol co-treated with Quercetin co-treated with Phytic Acid] results in increased expression of UCP3 mRNA CTD PMID:18657603 NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762 		JBrowse link
G Xdh xanthine dehydrogenase decreases activity EXP Phytic Acid results in decreased activity of XDH protein CTD PMID:14738912 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19921
    role 19896
      biological role 19894
        biochemical role 19584
          cofactor 15921
            myo-inositol hexakisphosphate 43
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19867
                    p-block element atom 19867
                      chalcogen 19616
                        oxygen atom 19589
                          oxygen molecular entity 19589
                            hydroxides 19384
                              oxoacid 18756
                                pnictogen oxoacid 13138
                                  phosphorus oxoacid 12392
                                    phosphoric acids 11426
                                      phosphoric acid 11426
                                        phosphoric acid derivative 11235
                                          phosphate 11234
                                            organic phosphate 11234
                                              cyclitol phosphate 62
                                                inositol phosphate 62
                                                  myo-inositol phosphate 62
                                                    myo-inositol polyphosphate 61
                                                      myo-inositol hexakisphosphates 43
                                                        myo-inositol hexakisphosphate 43
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