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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:myo-inositol hexakisphosphate
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Accession:CHEBI:17401 term browser browse the term
Definition:A myo-inositol hexakisphosphate in which each hydroxy group of myo-inositol is monophosphorylated.
Synonyms:exact_synonym: myo-inositol hexakis(dihydrogen phosphate)
 related_synonym: 1D-myo-Inositol 1,2,3,4,5,6-hexakisphosphate;   1D-myo-Inositol hexakisphosphate;   D-myo-Inositol 1,2,3,4,5,6-hexakisphosphate;   Formula=C6H18O24P6;   InChI=1S/C6H18O24P6/c7-31(8,9)25-1-2(26-32(10,11)12)4(28-34(16,17)18)6(30-36(22,23)24)5(29-35(19,20)21)3(1)27-33(13,14)15/h1-6H,(H2,7,8,9)(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)(H2,19,20,21)(H2,22,23,24)/t1-,2-,3-,4+,5-,6-;   InChIKey=IMQLKJBTEOYOSI-GPIVLXJGSA-N;   Inosithexaphosphorsaeure;   Phytate;   Phytic acid;   Phytine;   SMILES=OP(O)(=O)O[C@@H]1[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H]1OP(O)(O)=O;   Saeure des phytins;   acide fytique;   acido fitico;   acidum fyticum;   myo-inositol 1,2,3,4,5,6-hexakisphosphate
 alt_id: CHEBI:10603;   CHEBI:11366;   CHEBI:12829;   CHEBI:12832;   CHEBI:19200
 xref: Beilstein:2201952;   CAS:83-86-3;   Drug_Central:3465;   KEGG:C01204
 xref_mesh: MESH:D010833
 xref: MetaCyc:HEXAKISPHOSPHATE;   PMID:11217149;   PMID:11545369;   PMID:12070948;   PMID:12162428;   PMID:12816787;   PMID:12949395;   PMID:15325752;   PMID:15743020;   PMID:15918884;   PMID:15952339;   PMID:15998131;   PMID:16438310;   PMID:17162330;   PMID:18536177;   PMID:19331859;   PMID:21292245;   PMID:22023391;   PMID:6095072;   Reaxys:2201952;   Wikipedia:Phytic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:58130


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myo-inositol hexakisphosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases activity ISO Phytic Acid results in decreased activity of AKT1 protein CTD PMID:15868430 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Phytic Acid inhibits the reaction [Asbestos, Amosite results in increased activity of CASP3 protein] CTD PMID:11329530 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Phytic Acid inhibits the reaction [Asbestos, Amosite results in increased activity of CASP9 protein] CTD PMID:12540492, PMID:14766669 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions EXP [Phytic Acid co-treated with Inositol] inhibits the reaction [Streptozocin results in decreased activity of CAT protein] CTD PMID:28757134 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Phytic Acid inhibits the reaction [Urethane results in increased expression of CCND1 mRNA]; Phytic Acid inhibits the reaction [Urethane results in increased expression of CCND1 protein] CTD PMID:22797328 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression ISO Phytic Acid results in decreased expression of CDKN1B protein CTD PMID:15868430 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions
affects methylation
ISO Phytic Acid inhibits the reaction [Ethylnitrosourea results in decreased expression of CDKN2A]
Phytic Acid affects the methylation of CDKN2A promoter
CTD PMID:21154115 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Phytic Acid inhibits the reaction [Asbestos, Crocidolite results in decreased phosphorylation of EGFR protein] CTD PMID:15626777 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Ehmt2 euchromatic histone lysine methyltransferase 2 multiple interactions ISO Phytic Acid inhibits the reaction [Urethane results in increased expression of EHMT2 mRNA]; Phytic Acid inhibits the reaction [Urethane results in increased expression of EHMT2 protein] CTD PMID:25168426 NCBI chr20:4,576,033...4,592,980
Ensembl chr20:4,576,057...4,592,980
JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit multiple interactions ISO Phytic Acid inhibits the reaction [Urethane results in increased expression of EZH2 mRNA]; Phytic Acid inhibits the reaction [Urethane results in increased expression of EZH2 protein] CTD PMID:25168426 NCBI chr 4:77,284,404...77,347,011
Ensembl chr 4:77,284,404...77,347,011
JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO [resveratrol co-treated with Quercetin co-treated with Phytic Acid] results in increased expression of FOXO1 mRNA CTD PMID:18657603 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions EXP [Phytic Acid co-treated with Inositol] inhibits the reaction [Streptozocin results in decreased activity of G6PD protein] CTD PMID:28757134 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Phytic Acid inhibits the reaction [Urethane results in increased expression of IL6 mRNA]; Phytic Acid inhibits the reaction [Urethane results in increased expression of IL6 protein] CTD PMID:22797328 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases activity
multiple interactions
ISO
EXP
Phytic Acid results in decreased activity of MAPK1 protein
[resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased phosphorylation of MAPK1 protein
CTD PMID:15868430, PMID:21203465 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases activity
multiple interactions
ISO
EXP
Phytic Acid results in decreased activity of MAPK3 protein
[resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased phosphorylation of MAPK3 protein
CTD PMID:15868430, PMID:21203465 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mir101a microRNA 101a multiple interactions EXP [resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR101A mRNA CTD PMID:21203465 NCBI chr 5:120,168,437...120,168,511
Ensembl chr 5:120,168,433...120,168,515
JBrowse link
G Mir10a microRNA 10a multiple interactions EXP [resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR10A mRNA CTD PMID:21203465 NCBI chr10:84,165,950...84,166,059
Ensembl chr10:84,165,950...84,166,059
JBrowse link
G Mir138-1 microRNA 138-1 multiple interactions ISO Phytic Acid inhibits the reaction [Urethane results in decreased expression of MIR138-1 mRNA] CTD PMID:25168426 NCBI chr 8:131,731,726...131,731,824
Ensembl chr 8:131,731,726...131,731,824
JBrowse link
G Mir181c microRNA 181c multiple interactions EXP [resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR181C mRNA CTD PMID:21203465 NCBI chr19:25,290,211...25,290,316
Ensembl chr19:25,290,211...25,290,316
JBrowse link
G Mir20b microRNA 20b multiple interactions EXP [resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in decreased expression of MIR20B mRNA CTD PMID:21203465 NCBI chr  X:140,117,518...140,117,589
Ensembl chr  X:140,117,518...140,117,589
JBrowse link
G Mir21 microRNA 21 multiple interactions EXP [resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR21 mRNA CTD PMID:21203465 NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301
JBrowse link
G Mir25 microRNA 25 multiple interactions EXP [resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR25 mRNA CTD PMID:21203465 NCBI chr12:19,307,340...19,307,423
Ensembl chr12:19,307,340...19,307,423
JBrowse link
G Mir27b microRNA 27b multiple interactions EXP [resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in decreased expression of MIR27B mRNA CTD PMID:21203465 NCBI chr17:823,461...823,557
Ensembl chr17:823,461...823,557
JBrowse link
G Mir324 microRNA 324 multiple interactions EXP [resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR324 mRNA CTD PMID:21203465 NCBI chr10:56,621,126...56,621,208
Ensembl chr10:56,621,124...56,621,212
JBrowse link
G Mir339 microRNA 339 multiple interactions EXP [resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR339 mRNA CTD PMID:21203465 NCBI chr12:17,369,002...17,369,097
Ensembl chr12:17,369,002...17,369,097
JBrowse link
G Mir450a1 microRNA 450a-1 multiple interactions EXP [resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR450A1 mRNA CTD PMID:21203465 NCBI chr  X:158,153,377...158,153,467
Ensembl chr  X:158,153,377...158,153,467
JBrowse link
G Mir760 microRNA 760 multiple interactions EXP [resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR760 mRNA CTD PMID:21203465 NCBI chr 2:225,873,354...225,873,433
Ensembl chr 2:225,873,354...225,873,433
JBrowse link
G Mlh1 mutL homolog 1 multiple interactions
affects methylation
ISO Phytic Acid inhibits the reaction [Ethylnitrosourea results in increased expression of MLH1]
Phytic Acid affects the methylation of MLH1 promoter
CTD PMID:21154115 NCBI chr 8:119,486,655...119,523,716
Ensembl chr 8:119,486,691...119,523,964
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Phytic Acid inhibits the reaction [Urethane results in decreased expression of NFKB1 mRNA]; Phytic Acid inhibits the reaction [Urethane results in decreased expression of NFKB1 protein]; Phytic Acid inhibits the reaction [Urethane results in increased expression of NFKB1 mRNA]; Phytic Acid inhibits the reaction [Urethane results in increased expression of NFKB1 protein] CTD PMID:22797328 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Phytic Acid inhibits the reaction [Asbestos, Amosite results in increased activity of PARP1 protein]; Phytic Acid inhibits the reaction [Smoke analog results in increased activity of PARP1 protein] CTD PMID:11217149 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 multiple interactions ISO [resveratrol co-treated with Quercetin co-treated with Phytic Acid] results in increased expression of PDK4 mRNA CTD PMID:18657603 NCBI chr 4:30,546,772...30,556,774
Ensembl chr 4:30,546,664...30,556,814
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO [resveratrol co-treated with Quercetin co-treated with Phytic Acid] results in increased expression of PPARGC1A mRNA CTD PMID:18657603 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO Phytic Acid results in increased expression of and results in increased activity of and affects the localization of PRKCD protein CTD PMID:15868430 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
affects methylation
ISO Phytic Acid inhibits the reaction [Ethylnitrosourea results in increased expression of PTGS2]; Phytic Acid inhibits the reaction [Urethane results in increased expression of PTGS2 mRNA]; Phytic Acid inhibits the reaction [Urethane results in increased expression of PTGS2 protein]
Phytic Acid affects the methylation of PTGS2 promoter
CTD PMID:21154115, PMID:22797328 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO Phytic Acid results in decreased phosphorylation of RB1 protein CTD PMID:15868430 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Phytic Acid inhibits the reaction [Urethane results in increased expression of RELA mRNA]; Phytic Acid inhibits the reaction [Urethane results in increased expression of RELA protein] CTD PMID:22797328 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Phytic Acid inhibits the reaction [Urethane results in increased expression of and results in increased phosphorylation of STAT3 protein]; Phytic Acid inhibits the reaction [Urethane results in increased expression of STAT3 mRNA] CTD PMID:22797328 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Suv39h1 suppressor of variegation 3-9 homolog 1 multiple interactions ISO Phytic Acid inhibits the reaction [Urethane results in increased expression of SUV39H1 mRNA]; Phytic Acid inhibits the reaction [Urethane results in increased expression of SUV39H1 protein] CTD PMID:25168426 NCBI chr  X:146,532,002...146,533,538 JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO
EXP
Phytic Acid inhibits the reaction [Asbestos, Amosite results in increased expression of TP53 mRNA]; Phytic Acid inhibits the reaction [Asbestos, Amosite results in increased expression of TP53 protein] CTD PMID:16357363 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Ucp3 uncoupling protein 3 multiple interactions ISO [resveratrol co-treated with Quercetin co-treated with Phytic Acid] results in increased expression of UCP3 mRNA CTD PMID:18657603 NCBI chr 1:165,482,912...165,495,895
Ensembl chr 1:165,482,155...165,496,206
JBrowse link
G Xdh xanthine dehydrogenase decreases activity EXP Phytic Acid results in decreased activity of XDH protein CTD PMID:14738912 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        biochemical role 19282
          cofactor 15531
            myo-inositol hexakisphosphate 41
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      chalcogen 19362
                        oxygen atom 19323
                          oxygen molecular entity 19323
                            hydroxides 19068
                              oxoacid 18193
                                pnictogen oxoacid 10146
                                  phosphorus oxoacid 9033
                                    phosphoric acids 7795
                                      phosphoric acid 7795
                                        phosphoric acid derivative 7474
                                          phosphate 7474
                                            organic phosphate 7473
                                              cyclitol phosphate 58
                                                inositol phosphate 58
                                                  myo-inositol phosphate 58
                                                    myo-inositol polyphosphate 58
                                                      myo-inositol hexakisphosphates 41
                                                        myo-inositol hexakisphosphate 41
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.