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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:porphobilinogen
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Accession:CHEBI:17381 term browser browse the term
Definition:A dicarboxylic acid that is pyrole bearing aminomethyl, carboxymethyl and 2-carboxyethyl substituents at positions 2, 3 and 4 respectively.
Synonyms:related_synonym: 3-[5-(AMINOMETHYL)-4-(CARBOXYMETHYL)-1H-PYRROL-3-YL]PROPANOIC ACID;   Formula=C10H14N2O4;   InChI=1S/C10H14N2O4/c11-4-8-7(3-10(15)16)6(5-12-8)1-2-9(13)14/h5,12H,1-4,11H2,(H,13,14)(H,15,16);   InChIKey=QSHWIQZFGQKFMA-UHFFFAOYSA-N;   SMILES=NCc1[nH]cc(CCC(O)=O)c1CC(O)=O
 alt_id: CHEBI:14867;   CHEBI:26212;   CHEBI:44832;   CHEBI:8335
 xref: Beilstein:220051;   CAS:487-90-1;   DrugBank:DB02272;   HMDB:HMDB0000245;   KEGG:C00931;   KNApSAcK:C00007339
 xref_mesh: MESH:D011162
 xref: MetaCyc:PORPHOBILINOGEN;   PDBeChem:PBG;   PMID:21383008;   PMID:21627493;   PMID:22279024;   PMID:22740490;   PMID:22770225;   PMID:22974111;   Reaxys:220051;   Wikipedia:Porphobilinogen
 cyclic_relationship: is_conjugate_acid_of CHEBI:58126


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porphobilinogen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase multiple interactions EXP [cadmium acetate results in increased activity of ALAD protein] which results in increased chemical synthesis of Porphobilinogen; [Zinc Acetate results in increased activity of ALAD protein] which results in increased chemical synthesis of Porphobilinogen CTD PMID:21360559 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
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G Fech ferrochelatase multiple interactions ISO [Porphobilinogen results in decreased activity of FECH protein] which results in increased abundance of Iron CTD PMID:15078340 NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348
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Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19808
    role 19757
      biological role 19757
        biochemical role 19377
          metabolite 19352
            porphobilinogen 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19807
      composite particle 19807
        hadron 19807
          baryon 19807
            nucleon 19807
              atomic nucleus 19807
                atom 19807
                  main group element atom 19704
                    p-block element atom 19704
                      carbon group element atom 19626
                        carbon atom 19616
                          organic molecular entity 19616
                            organic molecule 19556
                              organic cyclic compound 19347
                                organic heterocyclic compound 18580
                                  heteroarene 16534
                                    monocyclic heteroarene 13438
                                      azole 12627
                                        pyrroles 5887
                                          porphobilinogen 2
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