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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:porphobilinogen
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Accession:CHEBI:17381 term browser browse the term
Definition:A dicarboxylic acid that is pyrole bearing aminomethyl, carboxymethyl and 2-carboxyethyl substituents at positions 2, 3 and 4 respectively.
Synonyms:related_synonym: 3-[5-(AMINOMETHYL)-4-(CARBOXYMETHYL)-1H-PYRROL-3-YL]PROPANOIC ACID;   Formula=C10H14N2O4;   InChI=1S/C10H14N2O4/c11-4-8-7(3-10(15)16)6(5-12-8)1-2-9(13)14/h5,12H,1-4,11H2,(H,13,14)(H,15,16);   InChIKey=QSHWIQZFGQKFMA-UHFFFAOYSA-N;   SMILES=NCc1[nH]cc(CCC(O)=O)c1CC(O)=O
 alt_id: CHEBI:14867;   CHEBI:26212;   CHEBI:44832;   CHEBI:8335
 xref: Beilstein:220051;   CAS:487-90-1;   DrugBank:DB02272;   HMDB:HMDB0000245;   KEGG:C00931;   KNApSAcK:C00007339
 xref_mesh: MESH:D011162
 xref: MetaCyc:PORPHOBILINOGEN;   PDBeChem:PBG;   PMID:21383008;   PMID:21627493;   PMID:22279024;   PMID:22740490;   PMID:22770225;   PMID:22974111;   Reaxys:220051;   Wikipedia:Porphobilinogen
 cyclic_relationship: is_conjugate_acid_of CHEBI:58126


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porphobilinogen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase multiple interactions EXP [cadmium acetate results in increased activity of ALAD protein] which results in increased chemical synthesis of Porphobilinogen; [Zinc Acetate results in increased activity of ALAD protein] which results in increased chemical synthesis of Porphobilinogen CTD PMID:21360559 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
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G Fech ferrochelatase multiple interactions ISO [Porphobilinogen results in decreased activity of FECH protein] which results in increased abundance of Iron CTD PMID:15078340 NCBI chr18:59,941,992...59,975,192
Ensembl chr18:59,941,992...59,975,192
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        biochemical role 19313
          metabolite 19294
            porphobilinogen 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                organic heterocyclic compound 18432
                                  heteroarene 16467
                                    monocyclic heteroarene 13313
                                      azole 12480
                                        pyrroles 5872
                                          porphobilinogen 2
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