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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cystine
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Accession:CHEBI:17376 term browser browse the term
Definition:A sulfur-containing amino acid obtained by the oxidation of two cysteine molecules which are then linked via a disulfide bond.
Synonyms:exact_synonym: 3,3'-disulfanediylbis(2-aminopropanoic acid)
 related_synonym: 3,3'-dithiobis(2-aminopropanoic acid);   Cystin;   Dicysteine;   Formula=C6H12N2O4S2;   InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12);   InChIKey=LEVWYRKDKASIDU-UHFFFAOYSA-N;   SMILES=NC(CSSCC(N)C(O)=O)C(O)=O;   Zystin;   alpha-Diamino-beta-dithiolactic acid;   cistina
 alt_id: CHEBI:14062;   CHEBI:23513;   CHEBI:4052
 xref: Beilstein:1728091;   CAS:923-32-0;   Gmelin:83347;   KEGG:C01420;   PMID:18608550;   PMID:24327171;   PMID:24525029;   PMID:24525030;   Reaxys:1728091;   Wikipedia:Cystine
 cyclic_relationship: is_tautomer_of CHEBI:35492


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L-cystine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kyat1 kynurenine aminotransferase 1 increases amination ISO KYAT1 protein results in increased amination of Cystine CTD PMID:22093698 NCBI chr 2:30,075,136...30,096,307
Ensembl chr 2:30,075,136...30,095,859 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions EXP Cystine affects the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein] CTD PMID:19850060 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions EXP Cystine affects the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein] CTD PMID:19850060 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Slc3a1 solute carrier family 3, member 1 increases uptake
multiple interactions		 ISO SLC3A1 protein results in increased uptake of Cystine
[SLC3A1 protein co-treated with SLC7A9 protein] results in increased uptake of Cystine		 CTD PMID:14978168 PMID:18845132 NCBI chr17:85,335,775...85,371,669
Ensembl chr17:85,335,804...85,371,664 		JBrowse link
G Slc3a2 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 multiple interactions EXP
ISO		 [SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine; Sulfasalazine inhibits the reaction [[SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine]
[[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide; [[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione; [Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine		 CTD PMID:19576933 PMID:22216172 NCBI chr19:8,684,931...8,700,733
Ensembl chr19:8,684,246...8,700,733 		JBrowse link
G Slc7a11 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 multiple interactions EXP
ISO		 [SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine; Sulfasalazine inhibits the reaction [[SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine]
[[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide; [[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione; [Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine		 CTD PMID:19576933 PMID:22216172 NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063 		JBrowse link
G Slc7a9 solute carrier family 7 (cationic amino acid transporter, y+ system), member 9 multiple interactions ISO [SLC3A1 protein co-treated with SLC7A9 protein] results in increased uptake of Cystine CTD PMID:14978168 NCBI chr 7:35,148,152...35,165,459
Ensembl chr 7:35,148,221...35,165,461 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    role 22194
      biological role 22162
        biochemical role 21431
          metabolite 21379
            fundamental metabolite 14986
              cysteine 3405
                cysteine derivative 3397
                  cystine 7
                    Cys-Gly disulfide 0
                    D-cystine + 0
                    L-cystine + 7
                    cystine residue + 0
                    cystinyl group + 0
                    cystyl group + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    main group molecular entity 22104
                      s-block molecular entity 21729
                        hydrogen molecular entity 21646
                          hydrides 20758
                            inorganic hydride 18672
                              pnictogen hydride 18652
                                nitrogen hydride 18519
                                  azane 18426
                                    ammonia 18425
                                      organic amino compound 18425
                                        amino acid 16428
                                          polar amino acid 12157
                                            cysteine 3405
                                              cysteine derivative 3397
                                                cystine 7
                                                  Cys-Gly disulfide 0
                                                  D-cystine + 0
                                                  L-cystine + 7
                                                  cystine residue + 0
                                                  cystinyl group + 0
                                                  cystyl group + 0
paths to the root