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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cystine
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Accession:CHEBI:17376 term browser browse the term
Definition:A sulfur-containing amino acid obtained by the oxidation of two cysteine molecules which are then linked via a disulfide bond.
Synonyms:exact_synonym: 3,3'-disulfanediylbis(2-aminopropanoic acid)
 related_synonym: 3,3'-dithiobis(2-aminopropanoic acid);   Cystin;   Dicysteine;   Formula=C6H12N2O4S2;   InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12);   InChIKey=LEVWYRKDKASIDU-UHFFFAOYSA-N;   SMILES=NC(CSSCC(N)C(O)=O)C(O)=O;   Zystin;   alpha-Diamino-beta-dithiolactic acid;   cistina
 alt_id: CHEBI:14062;   CHEBI:23513;   CHEBI:4052
 xref: Beilstein:1728091;   CAS:923-32-0;   Gmelin:83347;   KEGG:C01420;   PMID:18608550;   PMID:24327171;   PMID:24525029;   PMID:24525030;   Reaxys:1728091;   Wikipedia:Cystine
 cyclic_relationship: is_tautomer_of CHEBI:35492



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L-cystine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kyat1 kynurenine aminotransferase 1 increases amination ISO KYAT1 protein results in increased amination of Cystine CTD PMID:22093698 NCBI chr 3:13,459,598...13,493,308
Ensembl chr 3:13,459,591...13,493,355
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Cystine affects the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein] CTD PMID:19850060 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Cystine affects the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein] CTD PMID:19850060 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Slc3a1 solute carrier family 3 member 1 increases uptake
multiple interactions
ISO SLC3A1 protein results in increased uptake of Cystine
[SLC3A1 protein co-treated with SLC7A9 protein] results in increased uptake of Cystine
CTD PMID:14978168 PMID:18845132 NCBI chr 6:9,608,169...9,641,881
Ensembl chr 6:9,608,178...9,641,907
JBrowse link
G Slc3a2 solute carrier family 3 member 2 multiple interactions ISO [SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine; Sulfasalazine inhibits the reaction [[SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine]
[[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide; [[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione; [Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine
CTD PMID:19576933 PMID:22216172 NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931
JBrowse link
G Slc7a11 solute carrier family 7 member 11 multiple interactions ISO [SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine; Sulfasalazine inhibits the reaction [[SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine]
[[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide; [[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione; [Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine
CTD PMID:19576933 PMID:22216172 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Slc7a9 solute carrier family 7 member 9 multiple interactions ISO [SLC3A1 protein co-treated with SLC7A9 protein] results in increased uptake of Cystine CTD PMID:14978168 NCBI chr 1:88,109,517...88,132,653
Ensembl chr 1:88,110,644...88,132,641
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19740
    role 19713
      biological role 19711
        biochemical role 19429
          metabolite 19416
            fundamental metabolite 14070
              cysteine 3375
                cysteine derivative 3366
                  cystine 7
                    Cys-Gly disulfide 0
                    D-cystine + 0
                    L-cystine + 7
                    cystine residue + 0
                    cystinyl group + 0
                    cystyl group + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19740
    subatomic particle 19738
      composite particle 19738
        hadron 19738
          baryon 19738
            nucleon 19738
              atomic nucleus 19738
                atom 19738
                  main group element atom 19686
                    p-block element atom 19686
                      carbon group element atom 19631
                        carbon atom 19627
                          organic molecular entity 19627
                            organic group 18846
                              organic divalent group 18832
                                organodiyl group 18832
                                  carbonyl group 18798
                                    carbonyl compound 18798
                                      carboxylic acid 18518
                                        amino acid 15507
                                          polar amino acid 11673
                                            cysteine 3375
                                              cysteine derivative 3366
                                                cystine 7
                                                  Cys-Gly disulfide 0
                                                  D-cystine + 0
                                                  L-cystine + 7
                                                  cystine residue + 0
                                                  cystinyl group + 0
                                                  cystyl group + 0
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