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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hypoxanthine
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Accession:CHEBI:17368 term browser browse the term
Definition:A purine nucleobase that consists of purine bearing an oxo substituent at position 6.
Synonyms:related_synonym: 1,7-Dihydro-6H-purin-6-one;   6(1H)-purinone;   6-oxopurine;   9H-purin-6(1H)-one;   Formula=C5H4N4O;   Hyp;   InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10);   InChIKey=FDGQSTZJBFJUBT-UHFFFAOYSA-N;   Purine-6-ol;   SMILES=O=c1[nH]cnc2nc[nH]c12;   purin-6(1H)-one
 alt_id: CHEBI:14431;   CHEBI:24762;   CHEBI:43237;   CHEBI:5841
 xref: Beilstein:5811;   CAS:68-94-0;   DrugBank:DB04076;   ECMDB:ECMDB00157;   Gmelin:464558;   HMDB:HMDB0000157;   KEGG:C00262;   KNApSAcK:C00001502
 xref_mesh: MESH:D019271
 xref: MetaCyc:HYPOXANTHINE;   PDBeChem:HPA;   PMID:14253484;   PMID:1557408;   PMID:22735334;   PMID:23400363;   PMID:23670363;   PMID:8016081;   Reaxys:5811;   Wikipedia:Hypoxanthine;   YMDB:YMDB00555


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hypoxanthine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alpi alkaline phosphatase, intestinal multiple interactions ISO Hypoxanthine inhibits the reaction [Methotrexate results in increased activity of ALPI protein] CTD PMID:16598758 NCBI chr 9:94,197,616...94,201,910
Ensembl chr 9:94,197,618...94,201,084
JBrowse link
G B3gat3 beta-1,3-glucuronyltransferase 3 multiple interactions EXP [XDH protein co-treated with Hypoxanthine] inhibits the reaction [Glucosamine results in increased expression of B3GAT3 mRNA]; [XDH protein co-treated with Hypoxanthine] inhibits the reaction [Glucose results in increased expression of B3GAT3 mRNA] CTD PMID:11801247 NCBI chr 1:225,120,061...225,126,579
Ensembl chr 1:225,120,061...225,126,579
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [Mycophenolic Acid co-treated with Hypoxanthine] results in increased expression of BAX protein CTD PMID:21396949 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [3-hydrogenkwadaphnin co-treated with Hypoxanthine] results in decreased expression of BCL2 protein; [3-hydrogenkwadaphnin co-treated with Hypoxanthine] results in increased expression of BCL2 protein; [Mycophenolic Acid co-treated with Hypoxanthine] results in decreased expression of BCL2 protein CTD PMID:21396949 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [3-hydrogenkwadaphnin co-treated with Hypoxanthine] results in increased activity of CASP3 protein; [Mycophenolic Acid co-treated with Hypoxanthine] results in increased activity of CASP3 protein CTD PMID:21396949 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase multiple interactions ISO [Thymidine co-treated with Hypoxanthine co-treated with 5,6,7,8-tetrahydrofolic acid] inhibits the reaction [Methotrexate results in decreased expression of MTR protein]; [Thymidine co-treated with Hypoxanthine] inhibits the reaction [Methotrexate results in decreased expression of MTR protein] CTD PMID:16598758 NCBI chr17:66,210,444...66,295,014
Ensembl chr17:66,210,461...66,295,014
JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 decreases activity ISO Hypoxanthine results in decreased activity of NFATC1 protein CTD PMID:12203019 NCBI chr18:77,203,517...77,322,690
Ensembl chr18:77,203,525...77,322,690
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions
affects metabolic processing
ISO
EXP
[[Oxygen deficiency results in increased abundance of Hypoxanthine] affects the reaction [XDH protein affects the metabolism of Hypoxanthine]] which affects the abundance of Hydroxyl Radical; [XDH protein co-treated with Hypoxanthine] results in increased secretion of CXCL8 protein
[XDH protein co-treated with Hypoxanthine] inhibits the reaction [Glucosamine results in increased abundance of Proteoglycans]; [XDH protein co-treated with Hypoxanthine] inhibits the reaction [Glucosamine results in increased expression of B3GAT3 mRNA]; [XDH protein co-treated with Hypoxanthine] inhibits the reaction [Glucose results in increased abundance of Proteoglycans]; [XDH protein co-treated with Hypoxanthine] inhibits the reaction [Glucose results in increased expression of B3GAT3 mRNA]
CTD PMID:7929072 PMID:8969274 PMID:11801247 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link
inosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase decreases abundance
increases abundance
ISO ADA alternative form results in decreased abundance of Inosine
ADA protein results in increased abundance of Inosine
CTD PMID:16221767 NCBI chr 3:160,115,840...160,139,947
Ensembl chr 3:160,115,842...160,139,947
JBrowse link
G Faslg Fas ligand increases expression ISO Inosine results in increased expression of FASLG protein CTD PMID:16419169 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO Inosine inhibits the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form] CTD PMID:32941855 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Slc29a1 solute carrier family 29 member 1 multiple interactions ISO
EXP
Inosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine] CTD PMID:9353301 PMID:11085929 NCBI chr 9:17,784,468...17,799,008
Ensembl chr 9:17,784,468...17,799,005
JBrowse link
G Slc29a2 solute carrier family 29 member 2 multiple interactions ISO Inosine inhibits the reaction [SLC29A2 protein results in increased uptake of Uridine] CTD PMID:11085929 NCBI chr 1:220,306,622...220,314,631
Ensembl chr 1:220,400,855...220,407,189
Ensembl chr 1:220,400,855...220,407,189
JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 multiple interactions ISO Inosine inhibits the reaction [Cesium-137 results in increased expression of and affects the localization of TP53BP1 protein] CTD PMID:32941855 NCBI chr 3:113,160,030...113,259,701
Ensembl chr 3:113,160,000...113,231,790
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19761
    role 19711
      biological role 19711
        biochemical role 19301
          metabolite 19282
            fundamental metabolite 12653
              hypoxanthine 14
                9-riburonosylhypoxanthine 0
                inosine + 6
                methylhypoxanthine + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    p-block element atom 19653
                      carbon group element atom 19569
                        carbon atom 19559
                          organic molecular entity 19559
                            organic molecule 19493
                              organic cyclic compound 19318
                                organic heterocyclic compound 18510
                                  organic heteropolycyclic compound 17973
                                    organic heterobicyclic compound 16776
                                      imidazopyrimidine 5586
                                        purines 5584
                                          aminopurine 4418
                                            6-aminopurines 791
                                              adenine 785
                                                hypoxanthine 14
                                                  9-riburonosylhypoxanthine 0
                                                  inosine + 6
                                                  methylhypoxanthine + 0
paths to the root