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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2-acetamidofluorene
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Accession:CHEBI:17356 term browser browse the term
Definition:The parent of the class of 2-acetamidofluorenes, being an ortho-fused polycyclic arene that consists of 9H-fluorene bearing an acetamido substituent at position 2. It is a carcinogenic and mutagenic derivative of fluorene.
Synonyms:exact_synonym: N-(9H-fluoren-2-yl)acetamide
 related_synonym: 2-(Acetylamino)fluorene;   2-AAF;   2-ACETYLAMINOFLUORENE-3-YL;   2-Acetaminofluorene;   2-Acetoaminofluorene;   2-Acetylaminofluorene;   2-FAA;   Formula=C15H13NO;   InChI=1S/C15H13NO/c1-10(17)16-13-6-7-15-12(9-13)8-11-4-2-3-5-14(11)15/h2-7,9H,8H2,1H3,(H,16,17);   InChIKey=CZIHNRWJTSTCEX-UHFFFAOYSA-N;   N-2-Fluorenylacetamide;   N-Acetyl-2-aminofluorene;   N-fluoren-2-ylacetamide;   SMILES=C(=O)(NC=1C=C2C(C=3C(C2)=CC=CC3)=CC1)C
 alt_id: CHEBI:11494;   CHEBI:19431;   CHEBI:40645;   CHEBI:981
 xref: Beilstein:2807677;   CAS:53-96-3;   KEGG:C02778;   LINCS:LSM-37153
 xref_mesh: MESH:D015073
 xref: PDBeChem:AFF;   PMID:15380103;   PMID:17434228;   PMID:21417629;   PMID:21668357;   PMID:22514719;   PMID:23536516;   PMID:24021430;   PMID:7151044;   Reaxys:2807677;   Wikipedia:2-Acetylaminofluorene


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2-acetamidofluorene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aaas aladin WD repeat nucleoporin increases expression ISO 2-Acetylaminofluorene results in increased expression of AAAS mRNA CTD PMID:21607683 NCBI chr 7:143,937,198...143,956,668
Ensembl chr 7:143,937,199...143,956,668
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression
increases expression
multiple interactions
increases activity
ISO
EXP
2-Acetylaminofluorene results in decreased expression of ABCB1 mRNA
2-Acetylaminofluorene results in increased expression of ABCB1 mRNA; 2-Acetylaminofluorene results in increased expression of ABCB1A mRNA
lipopolysaccharide, E coli O55-B5 inhibits the reaction [2-Acetylaminofluorene results in increased expression of ABCB1A mRNA]
2-Acetylaminofluorene results in increased expression of ABCB1 mRNA; 2-Acetylaminofluorene results in increased expression of ABCB1 protein
Phycocyanin inhibits the reaction [2-Acetylaminofluorene results in increased expression of ABCB1 mRNA]; Phycocyanin inhibits the reaction [2-Acetylaminofluorene results in increased expression of ABCB1 protein]
2-Acetylaminofluorene results in increased activity of ABCB1 protein
[2-Acetylaminofluorene results in increased activity of AKT1 protein] which results in increased expression of ABCB1 mRNA; [2-Acetylaminofluorene results in increased activity of RAC1 protein] which results in increased expression of ABCB1 mRNA; [RELA protein binds to NFKB1 protein] affects the reaction [2-Acetylaminofluorene results in increased expression of ABCB1 mRNA]
CTD PMID:11170838, PMID:11960367, PMID:12387747, PMID:17303067, PMID:17669244, PMID:21784091, PMID:22213190 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B increases expression
multiple interactions
EXP 2-Acetylaminofluorene results in increased expression of ABCB1B mRNA; 2-Acetylaminofluorene results in increased expression of ABCB1B protein
[2-Acetylaminofluorene results in increased abundance of Reactive Oxygen Species] which results in increased expression of ABCB1B mRNA; lipopolysaccharide, E coli O55-B5 inhibits the reaction [2-Acetylaminofluorene results in increased expression of ABCB1B mRNA]; RELA protein affects the reaction [2-Acetylaminofluorene results in increased expression of ABCB1B mRNA]
CTD PMID:11020383, PMID:11170838, PMID:12801967, PMID:17070881, PMID:22084566 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression EXP 2-Acetylaminofluorene results in increased expression of ABCC1 mRNA CTD PMID:12801967, PMID:17669244 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc10 ATP binding cassette subfamily C member 10 increases expression ISO 2-Acetylaminofluorene results in increased expression of ABCC10 mRNA CTD PMID:12566991 NCBI chr 9:17,041,351...17,061,263
Ensembl chr 9:17,041,389...17,063,780
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression
multiple interactions
ISO 2-Acetylaminofluorene results in increased expression of ABCC2 mRNA
2-Acetylaminofluorene results in increased expression of ABCC2 mRNA; 2-Acetylaminofluorene results in increased expression of ABCC2 protein
NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of ABCC2 mRNA]
CTD PMID:10691972, PMID:16381673, PMID:16426233 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression ISO
EXP
2-Acetylaminofluorene results in increased expression of ABCC3 mRNA; 2-Acetylaminofluorene results in increased expression of ABCC3 protein CTD PMID:10691972, PMID:12801967 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases expression
increases activity
multiple interactions
ISO
EXP
2-Acetylaminofluorene results in increased expression of ABCG2 mRNA
2-Acetylaminofluorene results in increased activity of ABCG2 protein
2-Acetylaminofluorene results in increased expression of ABCG2 mRNA; 2-Acetylaminofluorene results in increased expression of ABCG2 protein
NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of ABCG2 mRNA]
CTD PMID:12819005, PMID:16381673, PMID:17538966, PMID:17669244, PMID:27475308 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Acaa2 acetyl-CoA acyltransferase 2 multiple interactions EXP [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of ACAA2 mRNA CTD PMID:14656948 NCBI chr18:70,733,872...70,762,395
Ensembl chr18:70,733,872...70,762,395
JBrowse link
G Acmsd aminocarboxymuconate semialdehyde decarboxylase decreases expression EXP 2-Acetylaminofluorene results in decreased expression of ACMSD mRNA CTD PMID:17070881 NCBI chr13:44,424,689...44,468,734
Ensembl chr13:44,424,689...44,468,734
JBrowse link
G Acot9 acyl-CoA thioesterase 9 increases expression EXP 2-Acetylaminofluorene results in increased expression of ACOT9 mRNA CTD PMID:21784091 NCBI chr  X:43,543,069...43,592,200
Ensembl chr  X:43,543,070...43,592,200
JBrowse link
G Acsl3 acyl-CoA synthetase long-chain family member 3 increases expression EXP 2-Acetylaminofluorene results in increased expression of ACSL3 mRNA CTD PMID:17070881 NCBI chr 9:84,569,601...84,593,565
Ensembl chr 9:84,569,597...84,593,565
JBrowse link
G Aen apoptosis enhancing nuclease increases expression ISO
EXP
2-Acetylaminofluorene results in increased expression of AEN mRNA CTD PMID:17070881, PMID:21607683, PMID:22584684 NCBI chr 1:140,584,328...140,593,749
Ensembl chr 1:140,584,380...140,593,745
JBrowse link
G Afp alpha-fetoprotein multiple interactions
increases expression
EXP [2-Acetylaminofluorene co-treated with Carbon Tetrachloride] affects the expression of AFP protein; [2-Acetylaminofluorene co-treated with Choline deficiency] results in increased expression of AFP protein
2-Acetylaminofluorene results in increased expression of AFP mRNA; 2-Acetylaminofluorene results in increased expression of AFP protein
CTD PMID:6187438, PMID:11350689, PMID:11813887, PMID:15133858, PMID:17538966 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
JBrowse link
G Ahr aryl hydrocarbon receptor increases expression ISO 2-Acetylaminofluorene results in increased expression of AHR mRNA CTD PMID:25224404 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Ak1 adenylate kinase 1 increases expression ISO 2-Acetylaminofluorene results in increased expression of AK1 mRNA CTD PMID:17317680 NCBI chr 3:11,652,143...11,659,135 JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B increases expression ISO 2-Acetylaminofluorene results in increased expression of AKR1B3 mRNA CTD PMID:17317680 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 multiple interactions
increases expression
EXP
ISO
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of AKR1B10 mRNA
2-Acetylaminofluorene results in increased expression of AKR1B10 mRNA
CTD PMID:14656948, PMID:26198647 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 increases expression EXP 2-Acetylaminofluorene results in increased expression of AKR7A3 mRNA CTD PMID:17070881 NCBI chr 5:157,801,120...157,813,756
Ensembl chr 5:157,801,163...157,813,756
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO 2-Acetylaminofluorene results in increased phosphorylation of and results in increased activity of AKT1 protein; [2-Acetylaminofluorene results in increased activity of AKT1 protein] which results in increased expression of ABCB1 mRNA
2-Acetylaminofluorene results in increased phosphorylation of and results in increased activity of AKT1 protein; Phycocyanin inhibits the reaction [2-Acetylaminofluorene results in increased phosphorylation of and results in increased activity of AKT1 protein]
CTD PMID:11960367, PMID:17303067 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alb albumin multiple interactions
increases expression
EXP [2-Acetylaminofluorene co-treated with Choline deficiency] results in increased expression of ALB protein
2-Acetylaminofluorene results in increased expression of ALB protein
CTD PMID:6187438, PMID:15133858 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP 2-Acetylaminofluorene results in increased expression of ALDH1A1 mRNA CTD PMID:17070881, PMID:22584684 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 increases expression EXP 2-Acetylaminofluorene results in increased expression of ALDH1A3 mRNA CTD PMID:22584684 NCBI chr 1:127,302,920...127,337,828
Ensembl chr 1:127,301,128...127,337,882
JBrowse link
G Aldh1a7 aldehyde dehydrogenase family 1, subfamily A7 increases expression EXP 2-Acetylaminofluorene results in increased expression of ALDH1A4 mRNA CTD PMID:17070881 NCBI chr 1:240,584,233...240,601,843
Ensembl chr 1:240,562,423...240,601,744
JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 multiple interactions ISO TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of ALDH3A1 mRNA] CTD PMID:17317680 NCBI chr10:47,490,168...47,499,855
Ensembl chr10:47,490,153...47,499,876
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased activity of ALPL protein; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of ALPL protein; Allyl Compounds inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of ALPL protein]; Sulfides inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of ALPL protein]; Tocotrienols affects the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased activity of ALPL protein] CTD PMID:15548946, PMID:15554553 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
JBrowse link
G Anapc11 anaphase promoting complex subunit 11 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of ANAPC11 mRNA CTD PMID:22584684 NCBI chr10:109,774,779...109,785,877
Ensembl chr10:109,774,878...109,785,877
JBrowse link
G Anxa3 annexin A3 increases expression
multiple interactions
ISO
EXP
2-Acetylaminofluorene results in increased expression of ANXA3 mRNA
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of ANXA3 mRNA]
[Carbon Tetrachloride co-treated with 2-Acetylaminofluorene] results in increased expression of ANXA3 mRNA
CTD PMID:17317680, PMID:18071240 NCBI chr14:14,371,921...14,426,503
Ensembl chr14:14,364,008...14,426,437
JBrowse link
G Anxa8 annexin A8 increases expression ISO 2-Acetylaminofluorene results in increased expression of ANXA8 mRNA CTD PMID:17317680 NCBI chr16:10,417,174...10,432,388
Ensembl chr16:10,417,185...10,432,393
JBrowse link
G Aox1 aldehyde oxidase 1 multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of AOX1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of AOX1 mRNA CTD PMID:14656948, PMID:16158176 NCBI chr 9:64,929,682...65,007,872
Ensembl chr 9:64,929,721...65,007,870
JBrowse link
G Apoa2 apolipoprotein A2 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of APOA2 mRNA CTD PMID:17070881 NCBI chr13:89,596,872...89,598,805
Ensembl chr13:89,597,138...89,598,802
JBrowse link
G Apoa4 apolipoprotein A4 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of APOA4 mRNA CTD PMID:17070881 NCBI chr 8:50,536,983...50,539,371
Ensembl chr 8:50,537,009...50,539,376
JBrowse link
G Apoc3 apolipoprotein C3 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of APOC3 mRNA CTD PMID:17070881 NCBI chr 8:50,529,318...50,531,498
Ensembl chr 8:50,529,318...50,531,498
JBrowse link
G Apod apolipoprotein D decreases expression ISO 2-Acetylaminofluorene results in decreased expression of APOD mRNA CTD PMID:20713471 NCBI chr11:72,705,204...72,726,263
Ensembl chr11:72,705,129...72,726,301
JBrowse link
G Aqp5 aquaporin 5 increases expression EXP 2-Acetylaminofluorene results in increased expression of AQP5 mRNA CTD PMID:17187413 NCBI chr 7:141,249,044...141,252,576
Ensembl chr 7:141,249,044...141,252,578
JBrowse link
G Areg amphiregulin increases expression
multiple interactions
ISO 2-Acetylaminofluorene results in increased expression of AREG mRNA
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of AREG mRNA]
CTD PMID:17317680 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179
JBrowse link
G Asgr1 asialoglycoprotein receptor 1 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of ASGR1 mRNA CTD PMID:17187413 NCBI chr10:56,662,188...56,666,086
Ensembl chr10:56,662,242...56,666,086
JBrowse link
G Atp6v1d ATPase H+ transporting V1 subunit D increases expression EXP 2-Acetylaminofluorene results in increased expression of ATP6V1D mRNA CTD PMID:17070881 NCBI chr 6:102,032,271...102,047,754
Ensembl chr 6:102,032,276...102,047,758
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO
EXP
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of BAX mRNA]
2-Acetylaminofluorene results in increased expression of BAX mRNA
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BAX protein; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BAX protein]
CTD PMID:11915028, PMID:17070881, PMID:17317680, PMID:19167416, PMID:21607683, PMID:22584684 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
EXP [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BCL2 protein; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BCL2 protein]
2-Acetylaminofluorene results in increased expression of BCL2 mRNA
CTD PMID:11915028, PMID:19167416, PMID:22213190 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
increases expression
EXP
ISO
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BCL2L1 protein; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BCL2L1 protein]
2-Acetylaminofluorene results in increased expression of BCL2L1 mRNA
CTD PMID:11915028, PMID:21607683 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 increases expression EXP 2-Acetylaminofluorene results in increased expression of BIRC5 mRNA CTD PMID:19167416, PMID:22213190 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Brca1 BRCA1, DNA repair associated increases expression EXP 2-Acetylaminofluorene results in increased expression of BRCA1 mRNA CTD PMID:19167416 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression EXP
ISO
2-Acetylaminofluorene results in increased expression of BTG2 mRNA CTD PMID:17070881, PMID:21607683 NCBI chr13:50,913,185...50,916,944
Ensembl chr13:50,913,180...50,916,982
JBrowse link
G Bzw1 basic leucine zipper and W2 domains 1 increases expression ISO 2-Acetylaminofluorene results in increased expression of BZW1 mRNA CTD PMID:17317680 NCBI chr 9:65,279,675...65,293,471
Ensembl chr 9:65,279,675...65,291,651
JBrowse link
G C4bpa complement component 4 binding protein, alpha decreases expression EXP 2-Acetylaminofluorene results in decreased expression of C4BPA mRNA CTD PMID:16510358 NCBI chr13:47,342,090...47,377,580
Ensembl chr13:47,342,079...47,377,703
JBrowse link
G C6 complement C6 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of C6 mRNA CTD PMID:22584684 NCBI chr 2:54,460,333...54,533,801
Ensembl chr 2:54,466,280...54,533,797
JBrowse link
G C7 complement C7 increases expression EXP 2-Acetylaminofluorene results in increased expression of C7 mRNA CTD PMID:17070881 NCBI chr 2:54,707,621...54,781,624
Ensembl chr 2:54,709,138...54,777,729
JBrowse link
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 increases expression EXP 2-Acetylaminofluorene results in increased expression of CACNA2D1 mRNA CTD PMID:17187413 NCBI chr 4:15,706,974...16,130,848
Ensembl chr 4:15,710,417...16,130,848
JBrowse link
G Cadm1 cell adhesion molecule 1 increases expression EXP 2-Acetylaminofluorene results in increased expression of CADM1 protein CTD PMID:17326163 NCBI chr 8:51,858,906...52,200,591
Ensembl chr 8:52,127,399...52,189,722
JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CAR2 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CAR2 mRNA CTD PMID:14656948, PMID:16158176 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity
EXP 2-Acetylaminofluorene inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] results in increased cleavage of CASP3 protein]; Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP3 protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of CASP3 protein] CTD PMID:12907702, PMID:23665045, PMID:26364502 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity
EXP Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP7 protein] CTD PMID:23665045 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp9 caspase 9 increases activity
increases expression
multiple interactions
EXP 2-Acetylaminofluorene results in increased activity of CASP9 protein
2-Acetylaminofluorene results in increased expression of CASP9 protein
Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP9 protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of CASP9 protein]
CTD PMID:23665045, PMID:26364502 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions
decreases activity
decreases expression
EXP [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of CAT protein; Diosmin inhibits the reaction [2-Acetylaminofluorene results in decreased expression of CAT protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in decreased activity of CAT protein] CTD PMID:17761372, PMID:23665045, PMID:26364502 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cavin3 caveolae associated protein 3 multiple interactions EXP [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CAVIN3 mRNA CTD PMID:14656948 NCBI chr 1:170,317,099...170,318,688
Ensembl chr 1:170,317,113...170,318,935
JBrowse link
G Cblc Cbl proto-oncogene C increases expression EXP 2-Acetylaminofluorene results in increased expression of CBLC mRNA CTD PMID:17070881 NCBI chr 1:80,699,321...80,716,146
Ensembl chr 1:80,699,323...80,716,146
JBrowse link
G Cbr1 carbonyl reductase 1 increases expression ISO 2-Acetylaminofluorene results in increased expression of CBR1 mRNA CTD PMID:21607683 NCBI chr11:33,813,041...33,815,418
Ensembl chr11:33,845,463...33,847,793
JBrowse link
G Cck cholecystokinin decreases expression EXP 2-Acetylaminofluorene results in decreased expression of CCK mRNA CTD PMID:22584684 NCBI chr 8:130,120,525...130,127,515
Ensembl chr 8:130,120,523...130,127,392
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 affects expression EXP 2-Acetylaminofluorene affects the expression of CCL2 mRNA; 2-Acetylaminofluorene affects the expression of CCL2 protein CTD PMID:25051504 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 increases expression EXP 2-Acetylaminofluorene results in increased expression of CCL7 protein CTD PMID:25051504 NCBI chr10:69,423,083...69,424,933
Ensembl chr10:69,423,086...69,424,979
JBrowse link
G Ccn2 cellular communication network factor 2 increases expression
multiple interactions
EXP 2-Acetylaminofluorene results in increased expression of CCN2 mRNA; 2-Acetylaminofluorene results in increased expression of CCN2 protein
Iloprost inhibits the reaction [2-Acetylaminofluorene results in increased expression of CCN2 mRNA]
CTD PMID:15940639 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Ccna2 cyclin A2 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of CCNA2 protein CTD PMID:15158336 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 decreases expression
increases expression
EXP 2-Acetylaminofluorene results in decreased expression of CCNB1 protein
2-Acetylaminofluorene results in increased expression of CCNB1 mRNA
CTD PMID:15158336, PMID:22584684 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnb2 cyclin B2 increases expression
multiple interactions
ISO
EXP
2-Acetylaminofluorene results in increased expression of CCNB2 mRNA
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of CCNB2 mRNA]
CTD PMID:17317680, PMID:19167416, PMID:22584684 NCBI chr 8:76,847,972...76,861,165 JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression
EXP [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCND1 mRNA; IFNA1 protein inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCND1 mRNA]
2-Acetylaminofluorene results in increased expression of CCND1 mRNA
CTD PMID:14633663, PMID:22584684 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccne1 cyclin E1 multiple interactions
decreases activity
EXP 2-Acetylaminofluorene inhibits the reaction [CDK2 protein binds to CCNE1 protein]; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCNE1 mRNA; IFNA1 protein inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCNE1 mRNA]
2-Acetylaminofluorene results in decreased activity of CCNE1 protein
CTD PMID:10708481, PMID:14633663 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Ccng1 cyclin G1 decreases expression
increases expression
EXP
ISO
2-Acetylaminofluorene results in decreased expression of CCNG1 mRNA
2-Acetylaminofluorene results in increased expression of CCNG1 mRNA
CTD PMID:17070881, PMID:17317680, PMID:19167416, PMID:21607683, PMID:22584684 NCBI chr10:25,903,925...25,910,298
Ensembl chr10:25,903,911...25,910,325
JBrowse link
G Cd276 Cd276 molecule increases expression EXP 2-Acetylaminofluorene results in increased expression of CD276 mRNA CTD PMID:17070881, PMID:21784091 NCBI chr 8:63,312,060...63,350,411
Ensembl chr 8:63,318,019...63,350,269
JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression EXP
IEP
2-Acetylaminofluorene results in increased expression of CD44 mRNA
2-Fluorenylacetamide increases CD44 mRNA in liver, and protein in liver and serum
CTD PMID:17187413, PMID:22584684, PMID:31966914 RGD:25823185 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cdc37 cell division cycle 37, HSP90 cochaperone multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CDC37 mRNA; [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CDC37 protein CTD PMID:16317707 NCBI chr 8:22,160,922...22,173,797
Ensembl chr 8:22,154,067...22,173,804
JBrowse link
G Cdca3 cell division cycle associated 3 increases expression EXP 2-Acetylaminofluorene results in increased expression of CDCA3 mRNA CTD PMID:22584684 NCBI chr 4:157,347,876...157,351,889
Ensembl chr 4:157,348,020...157,351,604
JBrowse link
G Cdh13 cadherin 13 increases expression EXP 2-Acetylaminofluorene results in increased expression of CDH13 mRNA CTD PMID:21784091 NCBI chr19:50,848,793...51,971,618
Ensembl chr19:50,848,736...51,972,103
JBrowse link
G Cdh22 cadherin 22 increases expression EXP 2-Acetylaminofluorene results in increased expression of CDH22 mRNA CTD PMID:17187413 NCBI chr 3:161,574,993...161,971,102
Ensembl chr 3:161,575,631...161,917,285
JBrowse link
G Cdh3 cadherin 3 increases expression EXP 2-Acetylaminofluorene results in increased expression of CDH3 mRNA CTD PMID:17187413 NCBI chr19:38,668,957...38,719,801
Ensembl chr19:38,669,230...38,719,677
JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression EXP 2-Acetylaminofluorene results in increased expression of CDK1 mRNA CTD PMID:19167416, PMID:22584684 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions
decreases activity
EXP 2-Acetylaminofluorene inhibits the reaction [CDK2 protein binds to CCNE1 protein]; 2-Acetylaminofluorene results in decreased localization of and results in decreased phosphorylation of and results in decreased activity of CDK2 protein
2-Acetylaminofluorene results in decreased activity of CDK2 protein
CTD PMID:10708481, PMID:15158336 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdk4 cyclin-dependent kinase 4 increases activity EXP 2-Acetylaminofluorene results in increased activity of CDK4 protein CTD PMID:15158336 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
EXP
ISO
2-Acetylaminofluorene inhibits the reaction [Diethylnitrosamine results in decreased expression of CDKN1A protein]; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of and affects the localization of CDKN1A protein; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CDKN1A mRNA; IFNA1 protein inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CDKN1A mRNA]; pioglitazone inhibits the reaction [2-Acetylaminofluorene inhibits the reaction [Diethylnitrosamine results in decreased expression of CDKN1A protein]]
2-Acetylaminofluorene results in increased expression of CDKN1A mRNA
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of CDKN1A mRNA]
2-Acetylaminofluorene results in increased expression of CDKN1A mRNA; 2-Acetylaminofluorene results in increased expression of CDKN1A protein
CTD PMID:10708481, PMID:11003613, PMID:14633663, PMID:17070881, PMID:17317680, PMID:17582756, PMID:19167416, PMID:21607683, PMID:22213190, PMID:22584684 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions EXP 2-Acetylaminofluorene promotes the reaction [Diethylnitrosamine results in decreased expression of CDKN1B protein]; Pioglitazone inhibits the reaction [2-Acetylaminofluorene promotes the reaction [Diethylnitrosamine results in decreased expression of CDKN1B protein]] CTD PMID:17582756 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions
increases expression
increases methylation
EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CDKN2A mRNA; [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CDKN2A protein
2-Acetylaminofluorene results in increased expression of CDKN2A mRNA
2-Acetylaminofluorene results in increased methylation of CDKN2A gene; 2-Acetylaminofluorene results in increased methylation of CDKN2A promoter
CTD PMID:16317707, PMID:18204080, PMID:19167416, PMID:20188851, PMID:22213190 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B increases expression ISO
EXP
2-Acetylaminofluorene results in increased expression of CDKN2B mRNA CTD PMID:17317680, PMID:22213190 NCBI chr 5:107,834,353...107,857,428
Ensembl chr 5:107,845,951...107,858,104
JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C increases expression EXP 2-Acetylaminofluorene results in increased expression of CDKN2C mRNA CTD PMID:22584684 NCBI chr 5:129,347,731...129,352,886
Ensembl chr 5:129,347,732...129,352,886
JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 increases expression EXP 2-Acetylaminofluorene results in increased expression of CDKN3 mRNA CTD PMID:22213190, PMID:22584684 NCBI chr15:23,553,171...23,564,538
Ensembl chr15:23,553,128...23,564,535
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression EXP 2-Acetylaminofluorene results in decreased expression of CEBPA protein CTD PMID:20188851, PMID:21785164 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions
decreases expression
EXP 2-Acetylaminofluorene inhibits the reaction [CEBPB protein binds to HAMP promoter]
2-Acetylaminofluorene results in decreased expression of CEBPB protein
CTD PMID:21785164 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Ces3a carboxylesterase 3a increases expression ISO 2-Acetylaminofluorene results in increased expression of CES3 mRNA CTD PMID:20713471 NCBI chr19:37,070,705...37,079,411 JBrowse link
G Ckmt1 creatine kinase, mitochondrial 1 increases expression ISO 2-Acetylaminofluorene results in increased expression of CKMT1 mRNA CTD PMID:17317680 NCBI chr 3:113,318,559...113,324,459
Ensembl chr 3:113,318,563...113,324,461
JBrowse link
G Cldn4 claudin 4 increases expression EXP 2-Acetylaminofluorene results in increased expression of CLDN4 mRNA CTD PMID:17187413 NCBI chr12:24,761,210...24,763,008
Ensembl chr12:24,761,210...24,763,005
JBrowse link
G Cldn7 claudin 7 increases expression EXP 2-Acetylaminofluorene results in increased expression of CLDN7 mRNA CTD PMID:17187413 NCBI chr10:56,576,326...56,578,632
Ensembl chr10:56,576,428...56,578,626
JBrowse link
G Clu clusterin multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CLU mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CLU mRNA CTD PMID:14656948, PMID:16158176 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Cmas cytidine monophosphate N-acetylneuraminic acid synthetase increases expression EXP 2-Acetylaminofluorene results in increased expression of CMAS protein CTD PMID:6331524 NCBI chr 4:176,994,129...177,012,445
Ensembl chr 4:176,994,129...177,012,444
JBrowse link
G Col17a1 collagen type XVII alpha 1 chain multiple interactions ISO TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of COL17A1 mRNA] CTD PMID:17317680 NCBI chr 1:267,416,681...267,465,049
Ensembl chr 1:267,417,459...267,463,705
JBrowse link
G Commd3 COMM domain containing 3 increases expression ISO 2-Acetylaminofluorene results in increased expression of COMMD3 mRNA CTD PMID:17317680 NCBI chr17:85,356,042...85,359,835
Ensembl chr17:85,356,042...85,359,833
JBrowse link
G Coq6 coenzyme Q6 monooxygenase multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of COQ6 mRNA CTD PMID:16158176 NCBI chr 6:108,076,393...108,087,782
Ensembl chr 6:108,076,306...108,087,696
JBrowse link
G Cpq carboxypeptidase Q decreases expression EXP 2-Acetylaminofluorene results in decreased expression of CPQ mRNA CTD PMID:17070881 NCBI chr 7:71,709,174...72,167,413
Ensembl chr 7:71,709,157...72,167,417
JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 multiple interactions EXP [2-Acetylaminofluorene co-treated with Carbon Tetrachloride] affects the expression of CPS1 protein CTD PMID:11813887 NCBI chr 9:74,113,437...74,236,274
Ensembl chr 9:74,124,016...74,236,274
JBrowse link
G Crebbp CREB binding protein decreases expression EXP 2-Acetylaminofluorene results in decreased expression of CREBBP mRNA CTD PMID:22213190 NCBI chr10:11,590,994...11,721,039
Ensembl chr10:11,595,044...11,721,039
JBrowse link
G Cryab crystallin, alpha B increases expression EXP 2-Acetylaminofluorene results in increased expression of CRYAB mRNA CTD PMID:17070881 NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545
JBrowse link
G Cryl1 crystallin, lambda 1 multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CRYL1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CRYL1 mRNA CTD PMID:14656948, PMID:16158176 NCBI chr15:37,543,727...37,663,586
Ensembl chr15:37,543,727...37,663,584
JBrowse link
G Csta cystatin A affects expression ISO 2-Acetylaminofluorene affects the expression of CSTA mRNA CTD PMID:27825931 NCBI chr11:67,555,792...67,566,980
Ensembl chr11:67,555,658...67,566,972
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 increases expression EXP 2-Acetylaminofluorene results in increased expression of CX3CL1 mRNA CTD PMID:17187413 NCBI chr19:10,644,267...10,654,861
Ensembl chr19:10,644,244...10,653,800
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 affects expression EXP 2-Acetylaminofluorene affects the expression of CXCL1 protein CTD PMID:25051504 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 affects expression EXP 2-Acetylaminofluorene affects the expression of CXCL10 protein CTD PMID:25051504 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 multiple interactions
increases expression
EXP [2-Acetylaminofluorene co-treated with Carbon Tetrachloride] results in increased expression of CXCL12 protein
2-Acetylaminofluorene results in increased expression of CXCL12 mRNA; 2-Acetylaminofluorene results in increased expression of CXCL12 protein
CTD PMID:12626097, PMID:15579440 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 affects expression EXP 2-Acetylaminofluorene affects the expression of CXCL2 protein CTD PMID:25051504 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression
multiple interactions
EXP 2-Acetylaminofluorene results in increased expression of CXCR4 mRNA
[2-Acetylaminofluorene co-treated with Carbon Tetrachloride] results in increased expression of CXCR4 protein
CTD PMID:12626097, PMID:15579440 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases hydrolysis
multiple interactions
increases expression
ISO
EXP
CYP1A1 results in increased hydrolysis of 2-Acetylaminofluorene
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [2-Acetylaminofluorene results in increased expression of CYP1A1 mRNA]
2-Acetylaminofluorene analog results in increased expression of CYP1A1 protein; 2-Acetylaminofluorene results in increased expression of CYP1A1 mRNA; 2-Acetylaminofluorene results in increased expression of CYP1A1 protein
CTD PMID:2334931, PMID:10445401, PMID:11888708, PMID:15916741, PMID:20713471, PMID:25224404 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects metabolic processing
increases expression
decreases expression
multiple interactions
increases hydrolysis
increases activity
ISO
EXP
CYP1A2 protein affects the metabolism of 2-Acetylaminofluorene
2-Acetylaminofluorene results in increased expression of CYP1A2 protein
2-Acetylaminofluorene results in increased expression of CYP1A2 mRNA
2-Acetylaminofluorene analog results in decreased expression of CYP1A2 protein; 2-Acetylaminofluorene results in decreased expression of CYP1A2 protein
NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of CYP1A2 mRNA]
CYP1A2 results in increased hydrolysis of 2-Acetylaminofluorene
CYP1A2 protein results in increased activity of 2-Acetylaminofluorene
CTD PMID:2334931, PMID:2655891, PMID:15450435, PMID:15916741, PMID:16381673, PMID:28245158 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression
multiple interactions
ISO 2-Acetylaminofluorene results in increased expression of CYP1B1 mRNA
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of CYP1B1 mRNA]
CTD PMID:17317680, PMID:20713471 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 increases expression ISO 2-Acetylaminofluorene results in increased expression of CYP2A22 mRNA CTD PMID:21607683 NCBI chr 1:83,711,223...83,725,222
Ensembl chr 1:83,653,234...83,766,484
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases expression
increases expression
EXP 2-Acetylaminofluorene analog results in decreased expression of CYP2B1 protein; 2-Acetylaminofluorene results in decreased expression of CYP2B1 protein
2-Acetylaminofluorene results in increased expression of CYP2B1 protein
CTD PMID:10445401, PMID:15916741 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 decreases expression EXP 2-Acetylaminofluorene analog results in decreased expression of CYP2B2 protein; 2-Acetylaminofluorene results in decreased expression of CYP2B2 protein CTD PMID:15916741 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
JBrowse link
G Cyp2c13 cytochrome P450, family 2, subfamily c, polypeptide 13 increases expression EXP 2-Acetylaminofluorene results in increased expression of CYP2C13 mRNA CTD PMID:17070881 NCBI chr 1:258,796,624...258,877,023
Ensembl chr 1:258,796,622...258,877,045
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases expression
EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of CYP2E1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CYP2E1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CYP2E1 protein; Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of CYP2E1 protein]
2-Acetylaminofluorene analog results in increased expression of CYP2E1 protein; 2-Acetylaminofluorene results in increased expression of CYP2E1 protein
CTD PMID:14656948, PMID:15916741, PMID:16158176, PMID:17393424, PMID:23665045 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression EXP 2-Acetylaminofluorene results in increased expression of CYP3A2 protein CTD PMID:10445401 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression
multiple interactions
EXP 2-Acetylaminofluorene results in increased expression of CYP3A23-3A1 mRNA; 2-Acetylaminofluorene results in increased expression of CYP3A23-3A1 protein
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of CYP3A23-3A1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CYP3A23-3A1 mRNA; NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of CYP3A23-3A1 mRNA]; Trabectedin inhibits the reaction [2-Acetylaminofluorene results in increased expression of CYP3A23-3A1 mRNA]
CTD PMID:12504080, PMID:14656948, PMID:16158176 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp4f5 cytochrome P450, family 4, subfamily f, polypeptide 5 increases expression EXP 2-Acetylaminofluorene results in increased expression of CYP4F5 mRNA CTD PMID:17070881 NCBI chr 7:14,559,806...14,574,345
Ensembl chr 7:14,529,482...14,574,361
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of CYP7A1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CYP7A1 mRNA CTD PMID:14656948, PMID:16158176 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Dap death-associated protein multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of DAP mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of DAP mRNA CTD PMID:14656948, PMID:16158176 NCBI chr 2:84,275,884...84,328,998
Ensembl chr 2:84,275,884...84,328,998
JBrowse link
G Ddah1 dimethylarginine dimethylaminohydrolase 1 increases expression EXP 2-Acetylaminofluorene results in increased expression of DDAH1 mRNA CTD PMID:17070881 NCBI chr 2:251,634,368...251,766,009
Ensembl chr 2:251,634,431...251,766,014
JBrowse link
G Ddit4l DNA-damage-inducible transcript 4-like increases expression ISO 2-Acetylaminofluorene results in increased expression of DDIT4L mRNA CTD PMID:21607683 NCBI chr 2:242,882,219...242,885,088
Ensembl chr 2:242,882,306...242,885,131
JBrowse link
G Ddr1 discoidin domain receptor tyrosine kinase 1 increases expression EXP 2-Acetylaminofluorene results in increased expression of DDR1 mRNA CTD PMID:17187413 NCBI chr20:3,553,430...3,574,959
Ensembl chr20:3,552,929...3,575,780
JBrowse link
G Des desmin increases expression EXP 2-Acetylaminofluorene results in increased expression of DES mRNA CTD PMID:17187413 NCBI chr 9:82,556,574...82,564,288
Ensembl chr 9:82,556,573...82,564,294
JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) decreases activity EXP 2-Acetylaminofluorene results in decreased activity of DHODH protein CTD PMID:6331524 NCBI chr19:42,066,103...42,087,906
Ensembl chr19:42,066,351...42,082,012
JBrowse link
G Dlk1 delta like non-canonical Notch ligand 1 increases expression EXP 2-Acetylaminofluorene results in increased expression of DLK1 mRNA; 2-Acetylaminofluorene results in increased expression of DLK1 protein CTD PMID:15567716, PMID:17187413, PMID:17538966 NCBI chr 6:133,576,513...133,583,751
Ensembl chr 6:133,552,821...133,583,751
JBrowse link
G Dmp1 dentin matrix acidic phosphoprotein 1 increases expression ISO 2-Acetylaminofluorene results in increased expression of DMP1 mRNA CTD PMID:17317680 NCBI chr14:6,889,851...6,923,961
Ensembl chr14:6,889,856...6,900,733
JBrowse link
G E2f1 E2F transcription factor 1 decreases expression
increases expression
EXP 2-Acetylaminofluorene results in decreased expression of E2F1 protein
2-Acetylaminofluorene results in increased expression of E2F1 mRNA
CTD PMID:15158336, PMID:19167416, PMID:22213190 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
G E2f3 E2F transcription factor 3 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of E2F3 protein CTD PMID:15158336, PMID:19167416 NCBI chr17:36,334,136...36,408,831
Ensembl chr17:36,334,147...36,408,831
JBrowse link
G E2f4 E2F transcription factor 4 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of E2F4 protein CTD PMID:15158336 NCBI chr19:37,252,828...37,260,239
Ensembl chr19:37,252,843...37,260,239
JBrowse link
G Eda2r ectodysplasin A2 receptor increases expression ISO 2-Acetylaminofluorene results in increased expression of EDA2R mRNA CTD PMID:21607683 NCBI chr  X:66,560,200...66,602,509
Ensembl chr  X:66,561,286...66,602,506
JBrowse link
G Egf epidermal growth factor decreases localization
multiple interactions
EXP 2-Acetylaminofluorene results in decreased localization of EGF protein
2-Acetylaminofluorene affects the reaction [EGF protein results in increased phosphorylation of EGFR protein]
CTD PMID:10900465 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
decreases expression
EXP 2-Acetylaminofluorene affects the reaction [EGF protein results in increased phosphorylation of EGFR protein]
2-Acetylaminofluorene results in decreased expression of EGFR mRNA
CTD PMID:10900465, PMID:22213190 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Egr1 early growth response 1 increases expression EXP 2-Acetylaminofluorene results in increased expression of EGR1 mRNA CTD PMID:19167416 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Ei24 EI24, autophagy associated transmembrane protein multiple interactions ISO TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of EI24 mRNA] CTD PMID:17317680 NCBI chr 8:39,254,883...39,271,238
Ensembl chr 8:39,254,889...39,266,959
JBrowse link
G Emp2 epithelial membrane protein 2 increases expression ISO 2-Acetylaminofluorene results in increased expression of EMP2 mRNA CTD PMID:21607683 NCBI chr10:5,433,248...5,467,840
Ensembl chr10:5,433,248...5,467,839
JBrowse link
G Enc1 ectodermal-neural cortex 1 increases expression ISO 2-Acetylaminofluorene results in increased expression of ENC1 mRNA CTD PMID:21607683 NCBI chr 2:28,049,217...28,061,023
Ensembl chr 2:28,049,217...28,061,029
JBrowse link
G Eno1 enolase 1 multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of ENO1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of ENO1 mRNA CTD PMID:14656948, PMID:16158176 NCBI chr 5:167,288,223...167,299,610
Ensembl chr 5:167,288,223...167,299,609
JBrowse link
G Epcam epithelial cell adhesion molecule increases expression EXP 2-Acetylaminofluorene results in increased expression of EPCAM mRNA CTD PMID:17070881, PMID:17187413 NCBI chr 6:11,282,194...11,308,870
Ensembl chr 6:11,281,964...11,298,216
JBrowse link
G Epha1 Eph receptor A1 increases expression ISO 2-Acetylaminofluorene results in increased expression of EPHA1 mRNA CTD PMID:17317680 NCBI chr 4:71,749,100...71,763,681
Ensembl chr 4:71,749,242...71,763,679
JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression EXP
ISO
2-Acetylaminofluorene results in increased expression of EPHX1 mRNA CTD PMID:17070881, PMID:17317680, PMID:21607683 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 increases expression EXP 2-Acetylaminofluorene results in increased expression of ERBB2 protein CTD PMID:11350689 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
G Esr1 estrogen receptor 1 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of ESR1 mRNA CTD PMID:19167416 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Exoc4 exocyst complex component 4 increases expression ISO 2-Acetylaminofluorene results in increased expression of EXOC4 mRNA CTD PMID:21607683 NCBI chr 4:60,549,128...61,358,305
Ensembl chr 4:60,549,197...61,355,994
JBrowse link
G Fam110a family with sequence similarity 110, member A increases expression ISO 2-Acetylaminofluorene results in increased expression of FAM110A mRNA CTD PMID:21607683 NCBI chr 3:147,476,580...147,487,170
Ensembl chr 3:147,476,580...147,487,170
JBrowse link
G Fas Fas cell surface death receptor increases expression EXP 2-Acetylaminofluorene results in increased expression of FAS mRNA CTD PMID:17070881, PMID:22584684 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fbxw9 F-box and WD repeat domain containing 9 increases expression ISO 2-Acetylaminofluorene results in increased expression of FBXW9 mRNA CTD PMID:21607683 NCBI chr19:26,173,771...26,180,675
Ensembl chr19:26,173,771...26,180,675
JBrowse link
G Fhit fragile histidine triad diadenosine triphosphatase decreases expression EXP 2-Acetylaminofluorene results in decreased expression of FHIT mRNA CTD PMID:17070881 NCBI chr15:15,697,292...16,862,873 JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 affects expression EXP 2-Acetylaminofluorene affects the expression of FLT3 mRNA CTD PMID:18031378 NCBI chr12:9,360,439...9,437,004
Ensembl chr12:9,360,672...9,436,570
JBrowse link
G Fn1 fibronectin 1 increases expression EXP 2-Acetylaminofluorene results in increased expression of FN1 mRNA CTD PMID:15940639 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of FOS protein; Drugs, Chinese Herbal inhibits the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of FOS protein] CTD PMID:17696247 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fth1 ferritin heavy chain 1 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of FTH1 protein CTD PMID:21785164 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
JBrowse link
G G6pc glucose-6-phosphatase, catalytic subunit multiple interactions EXP [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of G6PC protein; Allyl Compounds inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of G6PC protein]; Sulfides inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of G6PC protein] CTD PMID:15554553 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
JBrowse link
G Gaa glucosidase, alpha, acid increases expression ISO 2-Acetylaminofluorene results in increased expression of GAA mRNA CTD PMID:17317680 NCBI chr10:108,395,873...108,412,999
Ensembl chr10:108,395,860...108,413,059
JBrowse link
G Gas2l3 growth arrest-specific 2 like 3 decreases expression ISO 2-Acetylaminofluorene results in decreased expression of GAS2L3 mRNA CTD PMID:20713471 NCBI chr 7:29,963,129...29,996,021
Ensembl chr 7:29,959,597...29,986,163
JBrowse link
G Gcgr glucagon receptor multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GCGR mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GCGR mRNA CTD PMID:14656948, PMID:16158176 NCBI chr10:109,707,863...109,716,253
Ensembl chr10:109,707,962...109,716,128
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
ISO
EXP
2-Acetylaminofluorene results in increased expression of GCLC mRNA
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GCLC mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GCLC mRNA
CTD PMID:14656948, PMID:16158176, PMID:16426233 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GCLM mRNA CTD PMID:16158176 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO 2-Acetylaminofluorene results in increased expression of GDF15 mRNA CTD PMID:21607683 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 increases expression
multiple interactions
EXP 2-Acetylaminofluorene results in increased expression of GGT1 mRNA
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of GGT1 protein; Allyl Compounds inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of GGT1 protein]; Sulfides inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of GGT1 protein]
CTD PMID:15554553, PMID:17187413 NCBI chr20:14,019,723...14,045,781
Ensembl chr20:14,019,723...14,025,068
JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression EXP 2-Acetylaminofluorene results in increased expression of GJA1 mRNA; 2-Acetylaminofluorene results in increased expression of GJA1 protein CTD PMID:15133858, PMID:17187413 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Gjb1 gap junction protein, beta 1 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of GJB1 mRNA CTD PMID:2559087 NCBI chr  X:71,272,030...71,279,973
Ensembl chr  X:71,272,042...71,279,977
JBrowse link
G Gjb2 gap junction protein, beta 2 increases expression EXP 2-Acetylaminofluorene results in increased expression of GJB2 mRNA CTD PMID:22213190 NCBI chr15:37,377,313...37,394,494
Ensembl chr15:37,377,316...37,383,277
JBrowse link
G Glrx3 glutaredoxin 3 increases expression ISO 2-Acetylaminofluorene results in increased expression of GLRX3 mRNA CTD PMID:17317680 NCBI chr 1:209,768,696...209,799,912
Ensembl chr 1:209,768,696...209,799,903
JBrowse link
G Gpc3 glypican 3 increases expression EXP 2-Acetylaminofluorene results in increased expression of GPC3 mRNA CTD PMID:17187413 NCBI chr  X:139,579,268...139,947,093
Ensembl chr  X:139,579,268...139,916,883
JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GPX2 mRNA CTD PMID:14656948, PMID:16158176 NCBI chr 6:99,839,960...99,843,245
Ensembl chr 6:99,839,960...99,843,245
JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 increases expression EXP
ISO
2-Acetylaminofluorene results in increased expression of GRIA3 mRNA CTD PMID:17070881, PMID:21607683 NCBI chr  X:127,561,843...127,829,763
Ensembl chr  X:127,562,660...127,829,753
JBrowse link
G Grina glutamate ionotropic receptor NMDA type subunit associated protein 1 increases expression ISO 2-Acetylaminofluorene results in increased expression of GRINA mRNA CTD PMID:21607683 NCBI chr 7:117,304,742...117,307,916
Ensembl chr 7:117,304,742...117,307,916
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
decreases activity
decreases expression
EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GSR mRNA; Diosmin inhibits the reaction [2-Acetylaminofluorene results in decreased expression of GSR protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in decreased activity of GSR protein] CTD PMID:16158176, PMID:23665045, PMID:26364502 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gss glutathione synthetase increases expression ISO 2-Acetylaminofluorene results in increased expression of GSS mRNA CTD PMID:17317680 NCBI chr 3:151,076,254...151,106,557
Ensembl chr 3:151,076,254...151,106,557
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression
multiple interactions
ISO
EXP
2-Acetylaminofluorene results in increased expression of GSTA1 mRNA; 2-Acetylaminofluorene results in increased expression of GSTA2 mRNA
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GSTA2 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GSTA2 mRNA
CTD PMID:14656948, PMID:16158176, PMID:17317680 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta6 glutathione S-transferase alpha 6 increases expression ISO 2-Acetylaminofluorene results in increased expression of GSTA1 mRNA; 2-Acetylaminofluorene results in increased expression of GSTA2 mRNA CTD PMID:17317680 NCBI chr 9:27,475,273...27,533,939
Ensembl chr 9:27,475,273...27,511,176
JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression EXP 2-Acetylaminofluorene results in increased expression of GSTM1 mRNA CTD PMID:17070881 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
increases expression
EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GSTP1 protein; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of GSTP1 protein; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GSTP1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GSTP1 protein; Allyl Compounds inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of GSTP1 protein]; herbal compound 861 inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GSTP1 mRNA]; herbal compound 861 inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GSTP1 protein]; Plant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GSTP1 mRNA]; Plant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GSTP1 protein]; Sulfides inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of GSTP1 protein]
2-Acetylaminofluorene results in increased expression of GSTP1 mRNA; 2-Acetylaminofluorene results in increased expression of GSTP1 protein
CTD PMID:12497209, PMID:12781041, PMID:12907702, PMID:15554553, PMID:17393424, PMID:18271918, PMID:21785164, PMID:22213190 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Gtse1 G-2 and S-phase expressed 1 increases expression ISO 2-Acetylaminofluorene results in increased expression of GTSE1 mRNA CTD PMID:21607683 NCBI chr 7:126,736,416...126,753,221
Ensembl chr 7:126,736,732...126,753,220
JBrowse link
G H2ax H2A.X variant histone increases expression EXP 2-Acetylaminofluorene results in increased expression of H2AX protein CTD PMID:26338220 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of HADHA mRNA CTD PMID:16158176 NCBI chr 6:27,589,840...27,628,921
Ensembl chr 6:27,589,657...27,629,175
JBrowse link
G Hamp hepcidin antimicrobial peptide multiple interactions
decreases expression
EXP 2-Acetylaminofluorene inhibits the reaction [CEBPB protein binds to HAMP promoter]
2-Acetylaminofluorene results in decreased expression of HAMP mRNA
CTD PMID:21785164 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960
JBrowse link
G Hebp2 heme binding protein 2 multiple interactions ISO TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of HEBP2 mRNA] CTD PMID:17317680 NCBI chr 1:13,713,152...13,719,970
Ensembl chr 1:13,714,440...13,719,829
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of HMGCR mRNA; beta-ionone promotes the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of HMGCR mRNA] CTD PMID:20435455 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmox1 heme oxygenase 1 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of HMOX1 mRNA CTD PMID:22584684 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hras HRas proto-oncogene, GTPase increases expression EXP 2-Acetylaminofluorene results in increased expression of HRAS protein CTD PMID:11350689 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Hsd17b6 hydroxysteroid (17-beta) dehydrogenase 6 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of HSD17B6 mRNA CTD PMID:17070881 NCBI chr 7:2,412,370...2,431,249
Ensembl chr 7:2,412,363...2,431,197
Ensembl chr13:2,412,363...2,431,197
JBrowse link
G Ica1 islet cell autoantigen 1 increases expression EXP 2-Acetylaminofluorene results in increased expression of ICA1 mRNA CTD PMID:21784091 NCBI chr 4:34,635,509...34,780,187
Ensembl chr 4:34,635,506...34,780,193
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein increases expression ISO 2-Acetylaminofluorene results in increased expression of ID1 mRNA CTD PMID:15120964 NCBI chr 3:148,214,623...148,216,715
Ensembl chr 3:148,215,540...148,216,718
JBrowse link
G Ifna1 interferon, alpha 1 multiple interactions EXP IFNA1 protein inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CDKN1A mRNA]; IFNA1 protein inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCND1 mRNA]; IFNA1 protein inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCNE1 mRNA] CTD PMID:14633663 NCBI chr 5:106,951,822...106,952,908
Ensembl chr 5:106,952,082...106,952,792
JBrowse link
G Ifna2 interferon alpha 2 multiple interactions EXP IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BAX protein]; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BCL2 protein]; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BCL2L1 protein]; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of TP53 protein]; IFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TGFB1 protein]; IFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD2 protein]; IFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD3 protein] CTD PMID:11915028, PMID:15368444 NCBI chr 5:107,416,117...107,416,695
Ensembl chr 5:107,416,117...107,416,695
JBrowse link
G Ifng interferon gamma multiple interactions EXP 2-Acetylaminofluorene inhibits the reaction [[Diethylnitrosamine co-treated with Methylnitrosourea co-treated with Butylhydroxybutylnitrosamine co-treated with diisopropanolnitrosamine co-treated with 1,2-Dimethylhydrazine] results in decreased expression of IFNG protein] CTD PMID:14736494 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igf2 insulin-like growth factor 2 increases expression EXP 2-Acetylaminofluorene results in increased expression of IGF2 mRNA CTD PMID:22213190 NCBI chr 1:215,828,102...215,839,081
Ensembl chr 1:215,828,102...215,846,911
JBrowse link
G Igfals insulin-like growth factor binding protein, acid labile subunit decreases expression ISO 2-Acetylaminofluorene results in decreased expression of IGFALS mRNA CTD PMID:21607683 NCBI chr10:14,240,308...14,243,554
Ensembl chr10:14,240,219...14,243,597
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta increases activity ISO 2-Acetylaminofluorene results in increased activity of IKBKB protein CTD PMID:11960367 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Il10 interleukin 10 affects expression EXP 2-Acetylaminofluorene affects the expression of IL10 protein CTD PMID:25051504 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il12b interleukin 12B increases expression EXP 2-Acetylaminofluorene results in increased expression of IL12B protein CTD PMID:25051504 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il1b interleukin 1 beta multiple interactions
affects expression
increases expression
ISO
EXP
2-Acetylaminofluorene inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
2-Acetylaminofluorene affects the expression of IL1B mRNA
2-Acetylaminofluorene results in increased expression of IL1B protein
CTD PMID:14670622, PMID:25051504 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha increases expression EXP 2-Acetylaminofluorene results in increased expression of IL2RA mRNA CTD PMID:17070881 NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071
JBrowse link
G Il33 interleukin 33 increases expression ISO 2-Acetylaminofluorene results in increased expression of IL33 mRNA CTD PMID:17317680 NCBI chr 1:248,112,611...248,147,030
Ensembl chr 1:248,132,090...248,147,029
JBrowse link
G Il5 interleukin 5 increases expression EXP 2-Acetylaminofluorene results in increased expression of IL5 protein CTD PMID:25051504 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Il6 interleukin 6 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of IL6 protein CTD PMID:25051504 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itgb4 integrin subunit beta 4 increases expression ISO 2-Acetylaminofluorene results in increased expression of ITGB4 mRNA CTD PMID:17317680 NCBI chr10:104,524,000...104,560,180
Ensembl chr10:104,523,996...104,561,078
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of JUN protein; Drugs, Chinese Herbal inhibits the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of JUN protein] CTD PMID:17696247 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kdm6a lysine demethylase 6A decreases expression EXP 2-Acetylaminofluorene results in decreased expression of KDM6A mRNA CTD PMID:22213190 NCBI chr  X:4,805,493...4,945,788
Ensembl chr  X:4,806,277...4,945,944
JBrowse link
G Kif11 kinesin family member 11 increases expression EXP 2-Acetylaminofluorene results in increased expression of KIF11 mRNA CTD PMID:22584684 NCBI chr 1:256,035,866...256,088,299
Ensembl chr 1:256,035,866...256,088,299
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase increases expression EXP 2-Acetylaminofluorene results in increased expression of KIT protein CTD PMID:15133858 NCBI chr14:35,072,131...35,149,638
Ensembl chr14:35,072,108...35,149,610
JBrowse link
G Krt15 keratin 15 increases expression
multiple interactions
ISO 2-Acetylaminofluorene results in increased expression of KRT15 mRNA
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of KRT15 mRNA]
CTD PMID:17317680 NCBI chr10:88,046,803...88,050,622
Ensembl chr10:88,046,803...88,050,622
JBrowse link
G Krt19 keratin 19 increases expression
multiple interactions
EXP 2-Acetylaminofluorene results in increased expression of KRT19 mRNA; 2-Acetylaminofluorene results in increased expression of KRT19 protein
[Carbon Tetrachloride co-treated with 2-Acetylaminofluorene] results in increased expression of KRT19 protein
CTD PMID:15133858, PMID:17187413, PMID:17661067 NCBI chr10:88,055,843...88,060,560
Ensembl chr10:88,055,841...88,060,561
JBrowse link
G Krt20 keratin 20 decreases expression ISO 2-Acetylaminofluorene results in decreased expression of KRT20 mRNA CTD PMID:17317680 NCBI chr10:87,342,514...87,351,045
Ensembl chr10:87,342,619...87,351,045
JBrowse link
G Krt23 keratin 23 multiple interactions
increases expression
ISO TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of KRT23 mRNA] CTD PMID:17317680 NCBI chr10:87,391,623...87,407,634
Ensembl chr10:87,391,623...87,407,634
JBrowse link
G Krt4 keratin 4 increases expression
multiple interactions
ISO 2-Acetylaminofluorene results in increased expression of KRT4 mRNA
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of KRT4 mRNA]
CTD PMID:17317680 NCBI chr 7:143,517,562...143,523,522
Ensembl chr 7:143,518,010...143,523,503
JBrowse link
G Krt8 keratin 8 multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of KRT8 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of KRT8 mRNA CTD PMID:14656948, PMID:16158176 NCBI chr 7:143,596,511...143,603,745
Ensembl chr 7:143,596,511...143,603,803
JBrowse link
G Lep leptin increases expression EXP 2-Acetylaminofluorene results in increased expression of LEP protein CTD PMID:25051504 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lig4 DNA ligase 4 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of LIG4 mRNA CTD PMID:19167416 NCBI chr16:85,331,771...85,339,496
Ensembl chr16:85,331,866...85,337,769
JBrowse link
G LOC100910526 sulfotransferase 1C2-like decreases expression ISO 2-Acetylaminofluorene results in decreased expression of SULT1C2 mRNA CTD PMID:21607683 NCBI chr 9:4,820,678...4,834,271
Ensembl chr 9:4,807,717...4,834,335
JBrowse link
G LOC102550598 small proline-rich protein 2I-like increases expression ISO 2-Acetylaminofluorene results in increased expression of SPRR2G mRNA CTD PMID:17317680 NCBI chr 2:192,520,019...192,521,188
Ensembl chr 2:192,520,733...192,520,960
JBrowse link
G Ly6d lymphocyte antigen 6 family member D increases expression ISO 2-Acetylaminofluorene results in increased expression of LY6D mRNA CTD PMID:17317680 NCBI chr 7:115,993,304...115,994,812
Ensembl chr 7:115,993,301...115,994,783
JBrowse link
G Ly6e lymphocyte antigen 6 family member E increases expression ISO 2-Acetylaminofluorene results in increased expression of LY6E mRNA CTD PMID:21607683 NCBI chr 7:116,355,426...116,359,862
Ensembl chr 7:116,355,698...116,359,862
JBrowse link
G Lypd3 Ly6/Plaur domain containing 3 multiple interactions ISO TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of LYPD3 mRNA] CTD PMID:17317680 NCBI chr 1:81,499,856...81,504,306
Ensembl chr 1:81,499,821...81,504,318
JBrowse link
G Lzic leucine zipper and CTNNBIP1 domain containing increases expression ISO 2-Acetylaminofluorene results in increased expression of LZIC mRNA CTD PMID:21607683 NCBI chr 5:166,430,305...166,443,485
Ensembl chr 5:166,430,400...166,442,284
JBrowse link
G Mal mal, T-cell differentiation protein increases expression ISO 2-Acetylaminofluorene results in increased expression of MAL mRNA CTD PMID:17317680 NCBI chr 3:120,209,647...120,233,655
Ensembl chr 3:120,209,647...120,233,655
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP 2-Acetylaminofluorene affects the phosphorylation of and affects the activity of MAPK8 protein CTD PMID:17546627 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mat1a methionine adenosyltransferase 1A affects acetylation
decreases expression
affects methylation
EXP 2-Acetylaminofluorene affects the acetylation of MAT1A exon; 2-Acetylaminofluorene affects the acetylation of MAT1A promoter
2-Acetylaminofluorene results in decreased expression of MAT1A mRNA
2-Acetylaminofluorene affects the methylation of MAT1A exon; 2-Acetylaminofluorene affects the methylation of MAT1A promoter
CTD PMID:22213190 NCBI chr16:18,690,649...18,709,135
Ensembl chr16:18,690,246...18,709,133
JBrowse link
G Matn2 matrilin 2 increases expression EXP 2-Acetylaminofluorene results in increased expression of MATN2 mRNA; 2-Acetylaminofluorene results in increased expression of MATN2 protein CTD PMID:17513098 NCBI chr 7:72,985,832...73,210,093
Ensembl chr 7:72,985,495...73,207,695
JBrowse link
G Mbl2 mannose binding lectin 2 increases expression ISO 2-Acetylaminofluorene results in increased expression of MBL2 mRNA CTD PMID:21607683 NCBI chr 1:248,435,069...248,442,669
Ensembl chr 1:248,723,397...248,729,962
JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions
increases expression
EXP
ISO
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of and affects the localization of MDM2 protein
2-Acetylaminofluorene results in increased expression of MDM2 mRNA; 2-Acetylaminofluorene results in increased expression of MDM2 protein
CTD PMID:11003613, PMID:19167416, PMID:21607683, PMID:22213190, PMID:22584684 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases expression
decreases expression
EXP 2-Acetylaminofluorene results in increased expression of MGMT mRNA
2-Acetylaminofluorene results in decreased expression of MGMT mRNA
CTD PMID:17070881, PMID:22213190 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of MGST2 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of MGST2 mRNA CTD PMID:14656948, PMID:16158176 NCBI chr 2:140,708,396...140,727,381
Ensembl chr 2:140,708,397...140,727,281
JBrowse link
G Mir106b microRNA 106b increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR106B mRNA CTD PMID:19167416 NCBI chr12:19,307,752...19,307,833
Ensembl chr12:19,307,752...19,307,833
JBrowse link
G Mir125b1 microRNA 125b-1 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of MIR125B-1 mRNA CTD PMID:19167416 NCBI chr 8:45,798,260...45,798,346
Ensembl chr 8:45,798,260...45,798,346
JBrowse link
G Mir130b microRNA 130b increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR130B mRNA CTD PMID:19167416 NCBI chr11:88,129,773...88,129,854
Ensembl chr11:88,129,773...88,129,854
JBrowse link
G Mir132 microRNA 132 increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR132 mRNA CTD PMID:19167416 NCBI chr10:62,014,995...62,015,095
Ensembl chr10:62,014,995...62,015,095
JBrowse link
G Mir146b microRNA 146b increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR146B mRNA CTD PMID:19167416 NCBI chr 1:266,089,488...266,089,575
Ensembl chr 1:266,089,488...266,089,575
JBrowse link
G Mir155 microRNA 155 increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR155 mRNA CTD PMID:19167416 NCBI chr11:24,176,603...24,176,667
Ensembl chr11:24,176,603...24,176,667
JBrowse link
G Mir17 microRNA 17 increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR17; 2-Acetylaminofluorene results in increased expression of MIR17 mRNA CTD PMID:19167416, PMID:20188851 NCBI chr15:100,179,879...100,179,962
Ensembl chr15:100,179,879...100,179,962
JBrowse link
G Mir181b2 microRNA 181b-2 increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR181B-2 mRNA CTD PMID:19167416 NCBI chr 3:23,151,455...23,151,542
Ensembl chr 3:23,151,455...23,151,542
JBrowse link
G Mir181c microRNA 181c decreases expression EXP 2-Acetylaminofluorene results in decreased expression of MIR181C mRNA CTD PMID:19167416 NCBI chr19:25,290,211...25,290,316
Ensembl chr19:25,290,211...25,290,316
JBrowse link
G Mir185 microRNA 185 increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR185 mRNA CTD PMID:19167416 NCBI chr11:86,812,702...86,812,781
Ensembl chr11:86,812,702...86,812,781
JBrowse link
G Mir18a microRNA 18a increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR18A; 2-Acetylaminofluorene results in increased expression of MIR18A mRNA CTD PMID:19167416, PMID:20188851 NCBI chr15:100,180,015...100,180,110
Ensembl chr15:100,180,015...100,180,110
JBrowse link
G Mir200a microRNA 200a increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR200A mRNA CTD PMID:19167416, PMID:22584684 NCBI chr 5:173,489,366...173,489,454 JBrowse link
G Mir200b microRNA 200b increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR200B mRNA CTD PMID:19167416, PMID:22584684 NCBI chr 5:173,490,144...173,490,238
Ensembl chr 5:173,490,144...173,490,238
JBrowse link
G Mir200c microRNA 200c increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR200C mRNA CTD PMID:19167416 NCBI chr 4:157,236,786...157,236,854 JBrowse link
G Mir202 microRNA 202 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of MIR202 mRNA CTD PMID:19167416 NCBI chr 1:212,295,630...212,295,701
Ensembl chr 1:212,295,630...212,295,701
JBrowse link
G Mir204 microRNA 204 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of MIR204 mRNA CTD PMID:19167416 NCBI chr 1:240,403,000...240,403,109
Ensembl chr 1:240,403,000...240,403,109
JBrowse link
G Mir205 microRNA 205 increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR205 mRNA CTD PMID:19167416 NCBI chr13:112,233,283...112,233,390
Ensembl chr13:112,233,283...112,233,390
JBrowse link
G Mir20a microRNA 20a increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR20A; 2-Acetylaminofluorene results in increased expression of MIR20A mRNA CTD PMID:19167416, PMID:20188851 NCBI chr15:100,180,334...100,180,418
Ensembl chr15:100,180,334...100,180,418
JBrowse link
G Mir21 microRNA 21 increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR21 mRNA CTD PMID:19167416 NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301
JBrowse link
G Mir22 microRNA 22 increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR22 mRNA CTD PMID:22213190 NCBI chr10:62,299,592...62,299,686
Ensembl chr10:62,299,592...62,299,686
JBrowse link
G Mir221 microRNA 221 increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR221 mRNA CTD PMID:19167416 NCBI chr  X:3,684,480...3,684,588
Ensembl chr  X:3,684,480...3,684,588
JBrowse link
G Mir31 microRNA 31 increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR31; 2-Acetylaminofluorene results in increased expression of MIR31 mRNA CTD PMID:19167416, PMID:20188851 NCBI chr 5:107,206,515...107,206,620 JBrowse link
G Mir34a microRNA 34a increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR34A mRNA CTD PMID:19167416, PMID:22584684 NCBI chr 5:167,092,491...167,092,592
Ensembl chr 5:167,092,491...167,092,592
JBrowse link
G Mir3545 microRNA 3545 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of MIR203 mRNA CTD PMID:22584684 NCBI chr 6:136,704,947...136,705,061
Ensembl chr 6:136,704,947...136,705,061
JBrowse link
G Mir410 microRNA 410 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of MIR410 mRNA CTD PMID:19167416 NCBI chr 6:133,893,997...133,894,072
Ensembl chr 6:133,893,993...133,894,073
JBrowse link
G Mir429 microRNA 429 increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR429 mRNA CTD PMID:19167416, PMID:22584684 NCBI chr 5:173,488,331...173,488,415
Ensembl chr 5:173,488,331...173,488,415
JBrowse link
G Mir490 microRNA 490 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of MIR490 mRNA CTD PMID:19167416 NCBI chr 4:63,342,943...63,343,026
Ensembl chr 4:63,342,943...63,343,026
JBrowse link
G Mir93 microRNA 93 increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR93; 2-Acetylaminofluorene results in increased expression of MIR93 mRNA CTD PMID:19167416, PMID:20188851 NCBI chr12:19,307,543...19,307,629
Ensembl chr12:19,307,543...19,307,629
JBrowse link
G Mir96 microRNA 96 increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR96 mRNA CTD PMID:19167416 NCBI chr 4:57,463,366...57,463,471
Ensembl chr 4:57,463,366...57,463,471
JBrowse link
G Mir99a microRNA 99a decreases expression EXP 2-Acetylaminofluorene results in decreased expression of MIR99A mRNA CTD PMID:19167416, PMID:22584684 NCBI chr11:16,052,153...16,052,233
Ensembl chr11:16,052,153...16,052,233
JBrowse link
G Mirlet7b microRNA let-7b increases expression EXP 2-Acetylaminofluorene results in increased expression of MIRLET7B mRNA CTD PMID:19167416 NCBI chr 7:126,590,627...126,590,711
Ensembl chr 7:126,590,627...126,590,711
JBrowse link
G Mirlet7c1 microRNA let-7c-1 increases expression EXP 2-Acetylaminofluorene results in increased expression of MIRLET7C-1 mRNA CTD PMID:19167416 NCBI chr11:16,052,873...16,052,966
Ensembl chr11:16,052,868...16,052,975
JBrowse link
G Mirlet7i microRNA let-7i increases expression EXP 2-Acetylaminofluorene results in increased expression of MIRLET7I mRNA CTD PMID:19167416 NCBI chr 7:66,802,731...66,802,815
Ensembl chr 7:66,802,732...66,802,821
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions
increases expression
EXP
ISO
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of MKI67 protein; Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of MKI67 protein]; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of MKI67 protein]; Vanadium inhibits the reaction [2-Acetylaminofluorene results in increased expression of MKI67 protein]
2-Acetylaminofluorene results in increased expression of MKI67 mRNA
CTD PMID:15565650, PMID:17317680, PMID:17393424, PMID:23665045, PMID:26338220 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression EXP 2-Acetylaminofluorene results in increased expression of MMP2 mRNA CTD PMID:18678246 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression EXP 2-Acetylaminofluorene results in increased expression of MMP9 mRNA CTD PMID:18678246 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mt1 metallothionein 1 multiple interactions
increases expression
EXP Vanadium inhibits the reaction [2-Acetylaminofluorene results in increased expression of MT1A protein] CTD PMID:15565650 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mthfr methylenetetrahydrofolate reductase decreases expression
decreases methylation
EXP 2-Acetylaminofluorene results in decreased expression of MTHFR mRNA
2-Acetylaminofluorene results in decreased methylation of MTHFR promoter
CTD PMID:22213190 NCBI chr 5:164,844,642...164,864,360
Ensembl chr 5:164,845,925...164,860,910
JBrowse link
G Muc1 mucin 1, cell surface associated increases expression EXP 2-Acetylaminofluorene results in increased expression of MUC1 mRNA CTD PMID:17187413 NCBI chr 2:188,543,137...188,547,874
Ensembl chr 2:188,543,137...188,547,874
JBrowse link
G Mybl1 MYB proto-oncogene like 1 increases expression ISO 2-Acetylaminofluorene results in increased expression of MYBL1 mRNA CTD PMID:21607683 NCBI chr 5:9,279,756...9,315,112
Ensembl chr 5:9,279,970...9,315,114
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
increases mutagenesis
increases expression
EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of MYC protein; Drugs, Chinese Herbal inhibits the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of MYC protein]
2-Acetylaminofluorene results in increased mutagenesis of MYC gene
2-Acetylaminofluorene results in increased expression of MYC protein
CTD PMID:11350689, PMID:17696247, PMID:19167416, PMID:20188851 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase decreases expression EXP 2-Acetylaminofluorene results in decreased expression of NAMPT mRNA CTD PMID:22584684 NCBI chr 6:52,122,085...52,156,473
Ensembl chr 6:52,122,085...52,156,472
JBrowse link
G Nat1 N-acetyltransferase 1 increases activity ISO NAT1 protein results in increased activity of 2-Acetylaminofluorene CTD PMID:15450435 NCBI chr16:23,970,742...23,991,573
Ensembl chr16:23,970,743...23,991,573
JBrowse link
G Nat2 N-acetyltransferase 2 increases activity ISO NAT2 protein results in increased activity of 2-Acetylaminofluorene CTD PMID:15450435 NCBI chr16:23,960,709...23,991,570
Ensembl chr16:23,961,067...23,991,570
JBrowse link
G Nek6 NIMA-related kinase 6 increases expression EXP 2-Acetylaminofluorene results in increased expression of NEK6 mRNA CTD PMID:22584684 NCBI chr 3:22,811,927...22,888,598
Ensembl chr 3:22,811,927...22,888,598
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression
increases activity
ISO 2-Acetylaminofluorene results in increased expression of NFE2L2 mRNA
2-Acetylaminofluorene results in increased activity of NFE2L2 protein
CTD PMID:21607683, PMID:30114225 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
increases localization
ISO [RELA protein binds to NFKB1 protein] affects the reaction [2-Acetylaminofluorene results in increased expression of ABCB1 mRNA]
2-Acetylaminofluorene results in increased localization of NFKB1 protein
Phycocyanin inhibits the reaction [2-Acetylaminofluorene results in increased localization of NFKB1 protein]
CTD PMID:11960367, PMID:17303067 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased phosphorylation of NFKBIA protein; Acetylcysteine inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased phosphorylation of NFKBIA protein]; S-Adenosylmethionine inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased phosphorylation of NFKBIA protein] CTD PMID:18404532 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nfkbib NFKB inhibitor beta multiple interactions
increases degradation
EXP [2-Acetylaminofluorene results in increased abundance of Reactive Oxygen Species] which results in increased degradation of NFKBIB protein
2-Acetylaminofluorene results in increased degradation of NFKBIB protein
CTD PMID:11020383 NCBI chr 1:86,941,073...86,948,845
Ensembl chr 1:86,941,074...86,948,845
JBrowse link
G Ninj1 ninjurin 1 multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of NINJ1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of NINJ1 mRNA CTD PMID:14656948, PMID:16158176 NCBI chr17:15,866,235...15,881,284
Ensembl chr17:15,866,237...15,881,327
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
EXP [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of NOS2 protein; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of NOS2 protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of NOS2 protein] CTD PMID:23665045, PMID:26364502 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 increases expression
multiple interactions
ISO 2-Acetylaminofluorene results in increased expression of NOS3 mRNA
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of NOS3 mRNA]
CTD PMID:17317680 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Notch1 notch receptor 1 increases expression ISO 2-Acetylaminofluorene results in increased expression of NOTCH1 mRNA CTD PMID:21607683 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
G Nprl2 NPR2-like, GATOR1 complex subunit increases expression ISO 2-Acetylaminofluorene results in increased expression of NPRL2 mRNA CTD PMID:17317680 NCBI chr 8:116,297,950...116,301,123
Ensembl chr 8:116,297,950...116,301,122
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO
EXP
2-Acetylaminofluorene results in increased expression of NQO1 mRNA CTD PMID:21607683, PMID:22213190 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases expression
multiple interactions
ISO
EXP
2-Acetylaminofluorene results in increased expression of NR1I2 mRNA
NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of CYP3A23-3A1 mRNA]
NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of ABCC2 mRNA]; NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of ABCG2 mRNA]; NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of CYP1A2 mRNA]; NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of CYP3A11 mRNA]
CTD PMID:12504080, PMID:16381673 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nudcd2 NudC domain containing 2 increases expression ISO 2-Acetylaminofluorene results in increased expression of NUDCD2 mRNA CTD PMID:21607683 NCBI chr10:25,890,943...25,896,432
Ensembl chr10:25,890,943...25,896,432
JBrowse link
G Nudt7 nudix hydrolase 7 decreases expression ISO 2-Acetylaminofluorene results in decreased expression of NUDT7 mRNA CTD PMID:21607683 NCBI chr19:46,455,745...46,470,070
Ensembl chr19:46,455,761...46,482,050
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator decreases expression EXP 2-Acetylaminofluorene results in decreased expression of NUPR1 mRNA CTD PMID:17070881, PMID:22584684 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524
JBrowse link
G Nusap1 nucleolar and spindle associated protein 1 increases expression EXP 2-Acetylaminofluorene results in increased expression of NUSAP1 mRNA CTD PMID:22584684 NCBI chr 3:111,422,267...111,452,600
Ensembl chr 3:111,422,267...111,452,971
JBrowse link
G Ociad2 OCIA domain containing 2 increases expression ISO 2-Acetylaminofluorene results in increased expression of OCIAD2 mRNA CTD PMID:17317680 NCBI chr14:37,432,999...37,449,425
Ensembl chr14:37,435,654...37,444,775
JBrowse link
G Olfm1 olfactomedin 1 increases expression ISO 2-Acetylaminofluorene results in increased expression of OLFM1 mRNA CTD PMID:20713471 NCBI chr 3:6,761,031...6,798,739
Ensembl chr 3:6,773,813...6,798,737
JBrowse link
G Olr37 olfactory receptor 37 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of OLR37 mRNA CTD PMID:17070881 NCBI chr 1:164,755,094...164,756,059 JBrowse link
G Osm oncostatin M increases expression EXP 2-Acetylaminofluorene results in increased expression of OSM mRNA CTD PMID:15743783, PMID:18678246 NCBI chr14:84,457,487...84,469,426
Ensembl chr14:84,465,515...84,470,409
JBrowse link
G Osmr oncostatin M receptor increases expression EXP 2-Acetylaminofluorene results in increased expression of OSMR mRNA CTD PMID:15743783 NCBI chr 2:56,107,491...56,163,522
Ensembl chr 2:56,110,777...56,151,531
JBrowse link
G Padi2 peptidyl arginine deiminase 2 multiple interactions ISO TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of PADI2 mRNA] CTD PMID:17317680 NCBI chr 5:159,428,479...159,471,113
Ensembl chr 5:159,428,515...159,471,144
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of PCK1 mRNA CTD PMID:16510358 NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
increases expression
EXP [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PCNA protein; Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of PCNA protein]; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PCNA protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of PCNA protein]; Vanadium inhibits the reaction [2-Acetylaminofluorene results in increased expression of PCNA protein] CTD PMID:16352317, PMID:17393424, PMID:19167416, PMID:23665045, PMID:26364502 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of PDIA3 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PDIA3 mRNA CTD PMID:14656948, PMID:16158176 NCBI chr 3:113,376,983...113,400,707
Ensembl chr 3:113,376,983...113,400,707
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 increases expression EXP 2-Acetylaminofluorene results in increased expression of PECAM1 mRNA CTD PMID:17187413 NCBI chr10:94,850,971...94,913,202 JBrowse link
G Perp p53 apoptosis effector related to PMP22 multiple interactions ISO TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of PERP mRNA] CTD PMID:17317680 NCBI chr 1:14,224,392...14,236,838
Ensembl chr 1:14,224,393...14,236,846
JBrowse link
G Phlda3 pleckstrin homology-like domain, family A, member 3 increases expression ISO
EXP
2-Acetylaminofluorene results in increased expression of PHLDA3 mRNA CTD PMID:17070881, PMID:21607683, PMID:22584684 NCBI chr13:52,588,917...52,592,002
Ensembl chr13:52,588,917...52,592,001
JBrowse link
G Phyh phytanoyl-CoA 2-hydroxylase multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of PHYH mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of PHYH mRNA CTD PMID:14656948, PMID:16158176 NCBI chr17:77,287,580...77,304,482
Ensembl chr17:77,287,188...77,304,530
JBrowse link
G Piga phosphatidylinositol glycan anchor biosynthesis, class A increases mutagenesis EXP 2-Acetylaminofluorene results in increased mutagenesis of PIGA CTD PMID:22923490 NCBI chr  X:31,786,823...31,799,751
Ensembl chr  X:31,786,194...31,799,560
JBrowse link
G Pkd1 polycystin 1, transient receptor potential channel interacting decreases expression EXP 2-Acetylaminofluorene results in decreased expression of PKD1 mRNA CTD PMID:22584684 NCBI chr10:13,914,057...13,962,008
Ensembl chr10:13,915,214...13,962,008
JBrowse link
G Pkm pyruvate kinase M1/2 increases expression EXP 2-Acetylaminofluorene results in increased expression of PKM mRNA; 2-Acetylaminofluorene results in increased expression of PKM protein CTD PMID:17538966 NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722
JBrowse link
G Pkp1 plakophilin 1 increases expression ISO 2-Acetylaminofluorene results in increased expression of PKP1 mRNA CTD PMID:17317680 NCBI chr13:52,705,174...52,753,089
Ensembl chr13:52,705,174...52,752,997
JBrowse link
G Plk2 polo-like kinase 2 increases expression ISO 2-Acetylaminofluorene results in increased expression of PLK2 mRNA CTD PMID:21607683 NCBI chr 2:41,911,143...41,916,901
Ensembl chr 2:41,911,131...41,916,901
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression
multiple interactions
ISO
EXP
2-Acetylaminofluorene results in increased expression of PMAIP1 mRNA
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of PMAIP1 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of PMAIP1 mRNA]
CTD PMID:17317680, PMID:19167416 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
JBrowse link
G Polk DNA polymerase kappa increases expression ISO 2-Acetylaminofluorene results in increased expression of POLK mRNA CTD PMID:21607683 NCBI chr 2:27,305,718...27,364,906
Ensembl chr 2:27,305,728...27,364,906
JBrowse link
G Por cytochrome p450 oxidoreductase increases expression EXP 2-Acetylaminofluorene results in increased expression of POR mRNA CTD PMID:15089088 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Prc1 protein regulator of cytokinesis 1 increases expression EXP 2-Acetylaminofluorene results in increased expression of PRC1 mRNA CTD PMID:19167416 NCBI chr 1:142,087,181...142,108,746
Ensembl chr 1:142,087,208...142,108,746
JBrowse link
G Prkch protein kinase C, eta multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of PRKCH mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PRKCH mRNA CTD PMID:14656948, PMID:16158176 NCBI chr 6:96,479,243...96,677,368
Ensembl chr 6:96,479,430...96,676,225
JBrowse link
G Prom1 prominin 1 increases expression EXP 2-Acetylaminofluorene results in increased expression of PROM1 mRNA CTD PMID:17187413 NCBI chr14:71,532,321...71,637,400
Ensembl chr14:71,533,063...71,637,417
JBrowse link
G Prox1 prospero homeobox 1 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of PROX1 mRNA CTD PMID:22213190 NCBI chr13:108,382,536...108,444,107
Ensembl chr13:108,382,399...108,443,294
JBrowse link
G Psmd10 proteasome 26S subunit, non-ATPase 10 increases expression
multiple interactions
EXP 2-Acetylaminofluorene results in increased expression of PSMD10 protein
RB1 protein affects the reaction [2-Acetylaminofluorene results in increased expression of PSMD10 protein]
CTD PMID:16448463 NCBI chr  X:112,323,188...112,328,642
Ensembl chr  X:112,323,187...112,328,642
JBrowse link
G Psrc1 proline and serine rich coiled-coil 1 increases expression ISO 2-Acetylaminofluorene results in increased expression of PSRC1 mRNA CTD PMID:21607683 NCBI chr 2:211,176,437...211,181,078
Ensembl chr 2:211,176,556...211,181,123
JBrowse link
G Pten phosphatase and tensin homolog decreases expression EXP 2-Acetylaminofluorene results in decreased expression of PTEN protein CTD PMID:19167416 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Ptgr1 prostaglandin reductase 1 multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of PTGR1 mRNA CTD PMID:16158176 NCBI chr 5:76,110,746...76,129,361
Ensembl chr 5:76,110,738...76,129,441
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
EXP [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PTGS2 protein; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PTGS2 protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of PTGS2 protein] CTD PMID:23665045, PMID:26364502 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptn pleiotrophin increases expression EXP 2-Acetylaminofluorene results in increased expression of PTN mRNA CTD PMID:12057922 NCBI chr 4:64,239,156...64,330,996
Ensembl chr 4:64,239,158...64,330,996
JBrowse link
G Ptp4a3 protein tyrosine phosphatase 4A3 increases expression ISO 2-Acetylaminofluorene results in increased expression of PTP4A3 mRNA CTD PMID:17317680 NCBI chr 7:114,969,699...115,002,902
Ensembl chr 7:114,997,103...115,002,902
JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C increases expression EXP 2-Acetylaminofluorene results in increased expression of PTPRC mRNA CTD PMID:17187413 NCBI chr13:55,061,561...55,174,150
Ensembl chr13:55,061,562...55,173,692
JBrowse link
G Pttg1 PTTG1 regulator of sister chromatid separation, securin increases expression EXP 2-Acetylaminofluorene results in increased expression of PTTG1 mRNA CTD PMID:19167416 NCBI chr10:29,014,332...29,026,088
Ensembl chr10:29,020,049...29,026,002
JBrowse link
G Pvt1 Pvt1 oncogene increases expression ISO 2-Acetylaminofluorene results in increased expression of PVT1 mRNA CTD PMID:21607683 NCBI chr 7:102,648,394...102,871,316 JBrowse link
G Rac1 Rac family small GTPase 1 increases activity
multiple interactions
ISO 2-Acetylaminofluorene results in increased activity of RAC1 protein
[2-Acetylaminofluorene results in increased activity of RAC1 protein] which results in increased expression of ABCB1 mRNA
CTD PMID:11960367 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Rassf1 Ras association domain family member 1 increases methylation EXP 2-Acetylaminofluorene results in increased methylation of RASSF1 promoter CTD PMID:20188851 NCBI chr 8:116,307,149...116,318,289
Ensembl chr 8:116,307,141...116,318,289
JBrowse link
G Rb1 RB transcriptional corepressor 1 affects phosphorylation
multiple interactions
EXP 2-Acetylaminofluorene affects the phosphorylation of RB1 protein
2-Acetylaminofluorene results in increased expression of and results in increased phosphorylation of RB1 protein; RB1 protein affects the reaction [2-Acetylaminofluorene results in increased expression of PSMD10 protein]
CTD PMID:15158336, PMID:16448463 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rbx1 ring-box 1 increases expression ISO 2-Acetylaminofluorene results in increased expression of RBX1 mRNA CTD PMID:17317680 NCBI chr 7:122,700,849...122,710,907
Ensembl chr 7:122,700,854...122,709,935
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases activity
increases expression
multiple interactions
increases localization
ISO
EXP
2-Acetylaminofluorene results in increased activity of RELA protein
2-Acetylaminofluorene results in increased expression of RELA protein
geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of RELA protein]; RELA protein affects the reaction [2-Acetylaminofluorene results in increased expression of ABCB1B mRNA]
2-Acetylaminofluorene results in increased localization of RELA protein
[RELA protein binds to NFKB1 protein] affects the reaction [2-Acetylaminofluorene results in increased expression of ABCB1 mRNA]
2-Acetylaminofluorene inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]; Phycocyanin inhibits the reaction [2-Acetylaminofluorene results in increased localization of RELA protein]
CTD PMID:11020383, PMID:11960367, PMID:14670622, PMID:17303067, PMID:26364502 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rgn regucalcin multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of RGN mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of RGN mRNA CTD PMID:14656948, PMID:16158176 NCBI chr  X:1,833,484...1,848,904
Ensembl chr  X:1,833,492...1,848,904
JBrowse link
G Rgs2 regulator of G-protein signaling 2 increases expression EXP 2-Acetylaminofluorene results in increased expression of RGS2 mRNA CTD PMID:22584684 NCBI chr13:60,846,458...60,849,061
Ensembl chr13:60,846,308...60,849,094
JBrowse link
G Rhbdf2 rhomboid 5 homolog 2 increases expression ISO 2-Acetylaminofluorene results in increased expression of RHBDF2 mRNA CTD PMID:21607683 NCBI chr10:105,573,759...105,600,885
Ensembl chr10:105,573,752...105,600,913
JBrowse link
G Rhob ras homolog family member B increases expression EXP 2-Acetylaminofluorene results in increased expression of RHOB mRNA CTD PMID:22584684 NCBI chr 6:33,689,127...33,691,301
Ensembl chr 6:33,689,127...33,691,301
JBrowse link
G Rhobtb2 Rho-related BTB domain containing 2 increases expression EXP 2-Acetylaminofluorene results in increased expression of RHOBTB2 mRNA CTD PMID:17070881 NCBI chr15:51,465,148...51,485,562
Ensembl chr15:51,465,148...51,485,692
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of RIPK1 mRNA CTD PMID:22584684 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 increases expression ISO 2-Acetylaminofluorene results in increased expression of RIPK3 mRNA CTD PMID:17317680 NCBI chr15:34,470,796...34,479,741
Ensembl chr15:34,470,796...34,479,741
JBrowse link
G Ripk4 receptor-interacting serine-threonine kinase 4 increases expression ISO 2-Acetylaminofluorene results in increased expression of RIPK4 mRNA CTD PMID:21607683 NCBI chr11:38,251,991...38,274,234
Ensembl chr11:38,251,955...38,274,217
JBrowse link
G Ros1 ROS proto-oncogene 1 , receptor tyrosine kinase increases expression EXP 2-Acetylaminofluorene results in increased expression of ROS1 mRNA CTD PMID:17187413 NCBI chr20:33,100,190...33,323,544
Ensembl chr20:33,100,191...33,323,367
JBrowse link
G Rplp0 ribosomal protein lateral stalk subunit P0 multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of RPLP0 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of RPLP0 mRNA CTD PMID:14656948, PMID:16158176 NCBI chr12:46,791,528...46,794,797
Ensembl chr12:46,791,528...46,794,797
JBrowse link
G Rprm reprimo, TP53 dependent G2 arrest mediator homolog multiple interactions
increases expression
decreases expression
ISO
EXP
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of RPRM mRNA]
2-Acetylaminofluorene results in increased expression of RPRM mRNA
2-Acetylaminofluorene results in decreased expression of RPRM mRNA
CTD PMID:17317680, PMID:19167416, PMID:22584684 NCBI chr 3:39,595,301...39,596,718
Ensembl chr 3:39,595,301...39,596,718
JBrowse link
G Rps27l ribosomal protein S27-like increases expression ISO 2-Acetylaminofluorene results in increased expression of RPS27L mRNA CTD PMID:17317680 NCBI chr 8:72,741,155...72,746,090
Ensembl chr 8:72,741,155...72,746,090
JBrowse link
G Rrm1 ribonucleotide reductase catalytic subunit M1 increases expression ISO 2-Acetylaminofluorene results in increased expression of RRM1 mRNA CTD PMID:17317680 NCBI chr 1:167,538,387...167,562,688
Ensembl chr 1:167,538,263...167,562,688
JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B increases expression ISO 2-Acetylaminofluorene results in increased expression of RRM2B mRNA CTD PMID:21704725 NCBI chr 7:76,750,045...76,780,817
Ensembl chr 7:76,750,050...76,780,817
JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 decreases expression ISO 2-Acetylaminofluorene results in decreased expression of RSAD2 mRNA CTD PMID:20713471 NCBI chr 6:45,655,947...45,669,083
Ensembl chr 6:45,655,954...45,669,148
JBrowse link
G S100a11 S100 calcium binding protein A11 increases expression ISO 2-Acetylaminofluorene results in increased expression of S100A11 mRNA CTD PMID:17317680 NCBI chr 2:193,863,185...193,868,646
Ensembl chr 2:193,866,951...193,868,502
JBrowse link
G S100a14 S100 calcium binding protein A14 increases expression ISO 2-Acetylaminofluorene results in increased expression of S100A14 mRNA CTD PMID:17317680 NCBI chr 2:189,913,433...189,919,947 JBrowse link
G Scarb2 scavenger receptor class B, member 2 increases expression ISO 2-Acetylaminofluorene results in increased expression of SCARB2 mRNA CTD PMID:17317680 NCBI chr14:17,064,173...17,115,620
Ensembl chr14:17,064,353...17,115,963
JBrowse link
G Scpep1 serine carboxypeptidase 1 multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of SCPEP1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of SCPEP1 mRNA CTD PMID:14656948, PMID:16158176 NCBI chr10:76,230,371...76,263,866
Ensembl chr10:76,230,373...76,263,866
JBrowse link
G Sctr secretin receptor increases expression EXP 2-Acetylaminofluorene results in increased expression of SCTR mRNA CTD PMID:17187413 NCBI chr13:36,039,241...36,090,515
Ensembl chr13:36,039,283...36,090,530
JBrowse link
G Serpina7 serpin family A member 7 increases expression EXP 2-Acetylaminofluorene results in increased expression of SERPINA7 mRNA CTD PMID:17070881 NCBI chr  X:110,226,565...110,232,202
Ensembl chr  X:110,226,572...110,232,179
JBrowse link
G Serpinb5 serpin family B member 5 increases expression
multiple interactions
ISO 2-Acetylaminofluorene results in increased expression of SERPINB5 mRNA
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of SERPINB5 mRNA]
CTD PMID:17317680 NCBI chr13:26,903,052...26,923,250
Ensembl chr13:26,903,052...26,923,250
JBrowse link
G Serpinf1 serpin family F member 1 decreases expression ISO 2-Acetylaminofluorene results in decreased expression of SERPINF1 mRNA CTD PMID:21607683 NCBI chr10:62,241,750...62,254,145
Ensembl chr10:62,241,756...62,254,287
JBrowse link
G Sesn2 sestrin 2 increases expression ISO 2-Acetylaminofluorene results in increased expression of SESN2 mRNA CTD PMID:21607683 NCBI chr 5:150,684,891...150,703,846
Ensembl chr 5:150,684,133...150,704,117
JBrowse link
G Sfn stratifin increases expression EXP 2-Acetylaminofluorene results in increased expression of SFN mRNA CTD PMID:19167416, PMID:22213190 NCBI chr 5:151,823,422...151,824,937
Ensembl chr 5:151,823,887...151,824,633
JBrowse link
G Sirt1 sirtuin 1 increases expression EXP 2-Acetylaminofluorene results in increased expression of SIRT1 protein CTD PMID:19167416 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Slc15a5 solute carrier family 15, member 5 decreases expression ISO 2-Acetylaminofluorene results in decreased expression of SLC15A5 mRNA CTD PMID:21607683 NCBI chr 4:171,970,620...172,063,391
Ensembl chr 4:171,970,620...172,063,391
JBrowse link
G Slc16a10 solute carrier family 16 member 10 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of SLC16A10 mRNA CTD PMID:17070881 NCBI chr20:45,138,433...45,260,155
Ensembl chr20:45,143,453...45,260,119
JBrowse link
G Slc25a4 solute carrier family 25 member 4 multiple interactions ISO TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in decreased expression of SLC25A4 mRNA] CTD PMID:17317680 NCBI chr16:49,266,903...49,270,698
Ensembl chr16:49,266,903...49,270,698
JBrowse link
G Slc2a8 solute carrier family 2 member 8 multiple interactions ISO TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of SLC2A8 mRNA] CTD PMID:17317680 NCBI chr 3:12,020,227...12,029,920
Ensembl chr 3:12,020,229...12,029,877
JBrowse link
G Slc40a1 solute carrier family 40 member 1 increases expression EXP 2-Acetylaminofluorene results in increased expression of SLC40A1 mRNA CTD PMID:21785164 NCBI chr 9:52,819,451...52,830,461
Ensembl chr 9:52,894,365...52,912,293
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of SLCO1A4 mRNA CTD PMID:16158176 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of SLCO1B2 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of SLCO1B2 mRNA CTD PMID:14656948, PMID:16158176 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
JBrowse link
G Smad2 SMAD family member 2 multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD2 protein; IFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD2 protein] CTD PMID:15368444 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Smad3 SMAD family member 3 multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD3 protein; IFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD3 protein] CTD PMID:15368444 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Smad4 SMAD family member 4 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of SMAD4 mRNA CTD PMID:22213190 NCBI chr18:69,626,682...69,657,373
Ensembl chr18:69,627,757...69,671,199
JBrowse link
G Smo smoothened, frizzled class receptor increases expression EXP 2-Acetylaminofluorene results in increased expression of SMO mRNA CTD PMID:17187413 NCBI chr 4:57,019,941...57,041,779
Ensembl chr 4:57,019,941...57,042,770
JBrowse link
G Sncg synuclein, gamma increases expression EXP 2-Acetylaminofluorene results in increased expression of SNCG mRNA CTD PMID:22213190 NCBI chr16:10,722,110...10,726,648
Ensembl chr16:10,722,106...10,726,707
JBrowse link
G Sntg2 syntrophin, gamma 2 decreases expression ISO 2-Acetylaminofluorene results in decreased expression of SNTG2 mRNA CTD PMID:21607683 NCBI chr 6:49,123,084...49,324,530
Ensembl chr 6:49,123,084...49,324,450
JBrowse link
G Socs1 suppressor of cytokine signaling 1 increases expression EXP 2-Acetylaminofluorene results in increased expression of SOCS1 mRNA CTD PMID:22213190 NCBI chr10:4,956,795...4,958,472
Ensembl chr10:4,957,326...4,958,461
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of SOD1 protein CTD PMID:17761372 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of and results in increased activity of SOD2 protein; O-(Chloroacetylcarbamoyl)fumagillol inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of and results in increased activity of SOD2 protein] CTD PMID:17761372 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sox4 SRY-box transcription factor 4 increases expression EXP 2-Acetylaminofluorene results in increased expression of SOX4 mRNA CTD PMID:22584684 NCBI chr17:37,615,022...37,619,728 JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of SPINK1 mRNA CTD PMID:17070881 NCBI chr18:38,221,919...38,242,092
Ensembl chr18:38,221,681...38,242,119
JBrowse link
G Sprr1a small proline-rich protein 1A increases expression ISO 2-Acetylaminofluorene results in increased expression of SPRR1A mRNA CTD PMID:17317680 NCBI chr 2:192,669,143...192,671,059
Ensembl chr 2:192,669,143...192,671,059
JBrowse link
G Sprr2f small proline rich protein 2F increases expression
multiple interactions
ISO 2-Acetylaminofluorene results in increased expression of SPRR2F mRNA
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of SPRR2F mRNA]
CTD PMID:17317680 NCBI chr 2:192,604,978...192,605,208 JBrowse link
G Sptlc2 serine palmitoyltransferase, long chain base subunit 2 increases expression ISO 2-Acetylaminofluorene results in increased expression of SPTLC2 mRNA CTD PMID:17317680 NCBI chr 6:111,334,408...111,417,960
Ensembl chr 6:111,339,136...111,417,954
JBrowse link
G Sst somatostatin increases expression EXP 2-Acetylaminofluorene results in increased expression of SST protein CTD PMID:16534498 NCBI chr11:80,358,172...80,359,449
Ensembl chr11:80,358,211...80,359,444
JBrowse link
G St3gal3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 decreases expression ISO 2-Acetylaminofluorene results in decreased expression of ST3GAL3 mRNA CTD PMID:21607683 NCBI chr 5:136,765,309...136,965,642
Ensembl chr 5:136,766,208...136,965,191
JBrowse link
G St3gal5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 increases expression EXP 2-Acetylaminofluorene results in increased expression of ST3GAL5 protein CTD PMID:6331524 NCBI chr 4:99,937,499...99,999,905
Ensembl chr 4:99,937,558...99,999,902
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions EXP [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of STAT3 protein; Dexamethasone inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of STAT3 protein] CTD PMID:12957465 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Steap3 STEAP3 metalloreductase decreases expression EXP 2-Acetylaminofluorene results in decreased expression of STEAP3 mRNA CTD PMID:22584684 NCBI chr13:36,257,220...36,274,144
Ensembl chr13:36,257,112...36,290,531
JBrowse link
G Stmn1 stathmin 1 increases expression EXP 2-Acetylaminofluorene results in increased expression of STMN1 mRNA CTD PMID:22584684 NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806
JBrowse link
G Sugct succinylCoA:glutarate-CoA transferase decreases expression EXP 2-Acetylaminofluorene results in decreased expression of SUGCT mRNA CTD PMID:17070881 NCBI chr17:49,991,314...51,030,950 JBrowse link
G Sulf2 sulfatase 2 increases expression EXP
ISO
2-Acetylaminofluorene results in increased expression of SULF2 mRNA CTD PMID:17070881, PMID:21607683 NCBI chr 3:162,791,349...162,872,984
Ensembl chr 3:162,791,355...162,872,831
JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of SULT1E1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of SULT1E1 mRNA CTD PMID:14656948, PMID:16158176 NCBI chr14:22,070,861...22,089,264
Ensembl chr14:22,072,024...22,089,248
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of SULT2A1 mRNA CTD PMID:17070881 NCBI chr 1:76,558,721...76,614,315
Ensembl chr 1:76,252,329...76,780,230
JBrowse link
G Taldo1 transaldolase 1 multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TALDO1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of TALDO1 mRNA CTD PMID:14656948, PMID:16158176 NCBI chr 1:214,375,555...214,385,886
Ensembl chr 1:214,375,515...214,385,885
JBrowse link
G Tceal9 transcription elongation factor A like 9 multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TCEAL9 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of TCEAL9 mRNA CTD PMID:14656948, PMID:16158176 NCBI chr  X:106,791,333...106,794,667
Ensembl chr  X:106,791,333...106,794,657
JBrowse link
G Tes testin LIM domain protein increases expression EXP 2-Acetylaminofluorene results in increased expression of TES mRNA CTD PMID:21784091 NCBI chr 4:44,321,883...44,360,407
Ensembl chr 4:44,321,883...44,360,405
JBrowse link
G Tf transferrin decreases expression EXP 2-Acetylaminofluorene results in decreased expression of TF mRNA CTD PMID:16510358 NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
JBrowse link
G Tff1 trefoil factor 1 multiple interactions ISO TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of TFF1 mRNA] CTD PMID:17317680 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
JBrowse link
G Tff3 trefoil factor 3 increases expression EXP 2-Acetylaminofluorene results in increased expression of TFF3 mRNA CTD PMID:22213190 NCBI chr20:9,850,800...9,855,481
Ensembl chr20:9,850,803...9,855,481
JBrowse link
G Tfrc transferrin receptor increases expression EXP 2-Acetylaminofluorene results in increased expression of TFRC mRNA CTD PMID:21785164 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases expression
EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TGFB1 protein; IFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TGFB1 protein]
2-Acetylaminofluorene results in increased expression of TGFB1 mRNA
CTD PMID:15368444, PMID:15940639 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Thrb thyroid hormone receptor beta increases activity ISO 2-Acetylaminofluorene results in increased activity of THRB protein CTD PMID:31077750 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
G Thy1 Thy-1 cell surface antigen increases expression EXP 2-Acetylaminofluorene results in increased expression of THY1 protein CTD PMID:17576600 NCBI chr 8:48,382,121...48,387,271
Ensembl chr 8:48,382,121...48,386,935
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP 2-Acetylaminofluorene results in increased expression of TIMP1 mRNA CTD PMID:18678246 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tkt transketolase multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TKT mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of TKT mRNA CTD PMID:14656948, PMID:16158176 NCBI chr16:6,609,670...6,634,608
Ensembl chr16:6,609,668...6,634,595
JBrowse link
G Tmem134 transmembrane protein 134 increases expression ISO 2-Acetylaminofluorene results in increased expression of TMEM134 mRNA CTD PMID:17317680 NCBI chr 1:219,374,005...219,383,365
Ensembl chr 1:219,374,060...219,379,557
JBrowse link
G Tmem184c transmembrane protein 184C increases expression EXP 2-Acetylaminofluorene results in increased expression of TMEM184C mRNA CTD PMID:21784091 NCBI chr19:34,041,128...34,057,165
Ensembl chr19:34,041,219...34,057,159
JBrowse link
G Tmem43 transmembrane protein 43 increases expression ISO 2-Acetylaminofluorene results in increased expression of TMEM43 mRNA CTD PMID:21607683 NCBI chr 4:123,118,468...123,133,610
Ensembl chr 4:123,118,468...123,133,609
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TNF protein; Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of TNF protein] CTD PMID:18271918, PMID:23665045, PMID:25051504 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Top2a DNA topoisomerase II alpha increases expression EXP 2-Acetylaminofluorene results in increased expression of TOP2A mRNA CTD PMID:22584684 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
G Tp53 tumor protein p53 increases expression
decreases expression
increases response to substance
multiple interactions
EXP
ISO
2-Acetylaminofluorene results in increased expression of TP53 protein
2-Acetylaminofluorene results in increased expression of TRP53 protein
2-Acetylaminofluorene results in decreased expression of TP53 protein
TRP53 protein modified form results in increased susceptibility to 2-Acetylaminofluorene
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of BAX mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of CCNB2 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of CDKN1A mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of EI24 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of PERP mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of PMAIP1 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of RPRM mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of SERPINB5 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of ZMAT3 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in decreased expression of CYP4F15 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in decreased expression of MEG3 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in decreased expression of SLC25A4 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in decreased expression of TTR mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of ALDH3A1 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of ANXA3 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of AREG mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of COL17A1 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of CYP1B1 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of HEBP2 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of KRT15 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of KRT23 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of KRT4 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of LYPD3 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of NOS3 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of PADI2 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of PMAIP1 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of SLC2A8 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of SPRR2F mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of TFF1 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of TSHB mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of TUBA1C mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of UBE2C mRNA]
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of and affects the localization of TP53 protein; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of TP53 protein; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of TP53 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of TP53 protein; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of TP53 protein]; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of TP53 protein]; Vanadium promotes the reaction [2-Acetylaminofluorene results in increased expression of TP53 protein]
CTD PMID:7728945, PMID:9667752, PMID:10708481, PMID:11003613, PMID:11915028, PMID:12888115, PMID:14633663, PMID:15565650, PMID:17317680, PMID:19167416, PMID:23665045 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 multiple interactions
increases expression
EXP
ISO
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of TRP53INP1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of TRP53INP1 mRNA
2-Acetylaminofluorene results in increased expression of TP53INP1 mRNA
2-Acetylaminofluorene results in increased expression of TRP53INP1 mRNA
CTD PMID:14656948, PMID:16158176, PMID:21607683, PMID:22584684 NCBI chr 5:24,402,895...24,419,651
Ensembl chr 5:24,410,863...24,416,888
JBrowse link
G Tp73 tumor protein p73 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of TP73 mRNA CTD PMID:22213190 NCBI chr 5:171,355,876...171,415,354
Ensembl chr 5:171,355,876...171,415,354
JBrowse link
G Trpm2 transient receptor potential cation channel, subfamily M, member 2 multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TRPM2 mRNA CTD PMID:16158176 NCBI chr20:11,434,062...11,482,880
Ensembl chr20:11,436,267...11,482,051
JBrowse link
G Tsc22d1 TSC22 domain family, member 1 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of TSC22D1 mRNA CTD PMID:15089088 NCBI chr15:58,554,358...58,658,156
Ensembl chr15:58,554,374...58,658,153
JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions ISO TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of TSHB mRNA] CTD PMID:17317680 NCBI chr 2:205,207,799...205,215,199
Ensembl chr 2:205,207,799...205,212,681
JBrowse link
G Ttr transthyretin multiple interactions ISO TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in decreased expression of TTR mRNA] CTD PMID:17317680 NCBI chr18:15,532,963...15,542,180
Ensembl chr18:15,532,963...15,540,177
JBrowse link
G Tuba1c tubulin, alpha 1C multiple interactions ISO TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of TUBA1C mRNA] CTD PMID:17317680 NCBI chr 7:140,716,113...140,723,717
Ensembl chr 7:140,716,113...140,723,714
JBrowse link
G Tubb4b tubulin, beta 4B class IVb increases expression ISO
EXP
2-Acetylaminofluorene results in increased expression of TUBB4B mRNA CTD PMID:21607683, PMID:22584684 NCBI chr 3:2,441,585...2,444,369
Ensembl chr 3:2,441,733...2,444,281
JBrowse link
G Tubb5 tubulin, beta 5 class I increases expression EXP 2-Acetylaminofluorene results in increased expression of TUBB5 mRNA CTD PMID:22584684 NCBI chr20:3,422,448...3,426,420
Ensembl chr20:3,422,461...3,426,371
JBrowse link
G Tubb6 tubulin, beta 6 class V increases expression ISO 2-Acetylaminofluorene results in increased expression of TUBB6 mRNA CTD PMID:21607683 NCBI chr18:63,130,542...63,140,181
Ensembl chr18:63,130,542...63,140,181
JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C increases expression
multiple interactions
ISO
EXP
2-Acetylaminofluorene results in increased expression of UBE2C mRNA
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of UBE2C mRNA]
CTD PMID:17317680, PMID:22584684 NCBI chr 3:161,236,971...161,239,371
Ensembl chr 3:161,236,898...161,241,159
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of 2-Acetylaminofluorene analog CTD PMID:11375903 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression ISO
EXP
2-Acetylaminofluorene results in increased expression of VCAM1 mRNA
2-Acetylaminofluorene results in increased expression of VCAM1 protein
CTD PMID:21607683, PMID:25051504 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
multiple interactions
increases expression
EXP 2-Acetylaminofluorene results in decreased expression of VEGFA mRNA
geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of VEGFA protein]
CTD PMID:22213190, PMID:25051504, PMID:26364502 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Wee1 WEE1 G2 checkpoint kinase increases expression EXP 2-Acetylaminofluorene results in increased expression of WEE1 mRNA CTD PMID:22584684 NCBI chr 1:174,765,228...174,790,882
Ensembl chr 1:174,767,960...174,786,361
JBrowse link
G Wwox WW domain-containing oxidoreductase decreases expression ISO 2-Acetylaminofluorene results in decreased expression of WWOX mRNA CTD PMID:21607683 NCBI chr19:46,761,353...47,695,247 JBrowse link
G Xdh xanthine dehydrogenase increases activity
multiple interactions
EXP 2-Acetylaminofluorene results in increased activity of XDH protein
Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of XDH protein]
CTD PMID:23665045 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link
G Xpc XPC complex subunit, DNA damage recognition and repair factor decreases response to substance ISO XPC protein results in decreased susceptibility to 2-Acetylaminofluorene CTD PMID:23153559 NCBI chr 4:123,134,457...123,161,985
Ensembl chr 4:123,134,457...123,161,985
JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of ZEB1 protein CTD PMID:19167416 NCBI chr17:54,656,627...54,714,920
Ensembl chr17:54,658,463...54,714,914
JBrowse link
G Zeb2 zinc finger E-box binding homeobox 2 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of ZEB2 protein CTD PMID:19167416 NCBI chr 3:29,857,289...29,985,932
Ensembl chr 3:29,862,473...29,996,865
JBrowse link
G Zmat3 zinc finger, matrin type 3 multiple interactions
increases expression
ISO
EXP
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of ZMAT3 mRNA]
2-Acetylaminofluorene results in increased expression of ZMAT3 mRNA
CTD PMID:17070881, PMID:17317680, PMID:19167416, PMID:21607683, PMID:22584684 NCBI chr 2:118,715,229...118,746,109
Ensembl chr 2:118,721,334...118,745,766
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19792
    role 19738
      biological role 19737
        epitope 6841
          2-acetamidofluorene 424
            2-acetamidofluorene N-sulfate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19792
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19675
                    main group molecular entity 19675
                      s-block molecular entity 19420
                        hydrogen molecular entity 19411
                          hydrides 18460
                            organic hydride 17773
                              organic fundamental parent 17773
                                hydrocarbon 17294
                                  cyclic hydrocarbon 15325
                                    arene 15315
                                      polycyclic arene 14779
                                        ortho-fused polycyclic arene 9610
                                          fluorene 553
                                            fluorenes 426
                                              2-acetamidofluorenes 424
                                                2-acetamidofluorene 424
                                                  2-acetamidofluorene N-sulfate 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.