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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:linoleic acid
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Accession:CHEBI:17351 term browser browse the term
Definition:An octadecadienoic acid in which the two double bonds are at positions 9 and 12 and have Z (cis) stereochemistry.
Synonyms:related_synonym: (9Z,12Z)-octadeca-9,12-dienoic acid;   (Z,Z)-9,12-octadecadienoic acid;   9-cis,12-cis-Octadecadienoic acid;   9Z,12Z-octadecadienoic acid;   C18:2 9c, 12c omega6 todos cis-9,12-octadienoico;   C18:2, n-6,9 all-cis;   Formula=C18H32O2;   InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6-,10-9-;   InChIKey=OYHQOLUKZRVURQ-HZJYTTRNSA-N;   LA;   SMILES=CCCCC\\C=C/C\\C=C/CCCCCCCC(O)=O;   acide cis-linoleique;   acide linoleique;   acido linoleico;   all-cis-9,12-octadecadienoic acid;   cis,cis-linoleic acid;   cis-Delta(9,12)-octadecadienoic acid;   linolic acid
 alt_id: CHEBI:25047;   CHEBI:42395;   CHEBI:6479
 xref: Beilstein:1727101;   CAS:60-33-3;   Drug_Central:3323;   Gmelin:57557;   HMDB:HMDB0000673;   KEGG:C01595;   KNApSAcK:C00001224;   LIPID_MAPS_instance:LMFA01030120
 xref_mesh: MESH:D019787
 xref: MetaCyc:LINOLEIC_ACID;   PDBeChem:EIC;   PMID:11113630;   PMID:11304127;   PMID:11322990;   PMID:14667063;   PMID:14993245;   PMID:15115315;   PMID:15642793;   PMID:15969511;   PMID:16254037;   PMID:16563718;   PMID:17647039;   PMID:18044828;   PMID:18990554;   PMID:19628674;   PMID:19936816;   PMID:23900039;   PMID:24081493;   PMID:6205897;   Reaxys:1727101;   Wikipedia:Linoleic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:30245

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linoleic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions
decreases expression
increases expression
increases phosphorylation
increases degradation		 ISO 1-Butanol inhibits the reaction [Linoleic Acid inhibits the reaction [ABCA1 protein results in increased export of Cholesterol]]; Linoleic Acid inhibits the reaction [ABCA1 protein results in increased export of Cholesterol]; Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]; Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Phospholipids]]; PLD2 protein inhibits the reaction [Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]]]; triacsin C inhibits the reaction [Linoleic Acid inhibits the reaction [ABCA1 protein results in increased transport of Cholesterol]]; triacsin C inhibits the reaction [Linoleic Acid inhibits the reaction [ABCA1 protein results in increased transport of Phospholipids]]; triacsin C inhibits the reaction [Linoleic Acid results in increased degradation of ABCA1 protein]
Linoleic Acid analog results in decreased expression of ABCA1 mRNA
Linoleic Acid results in increased expression of ABCA1 mRNA
Linoleic Acid inhibits the reaction [27-hydroxycholesterol results in increased expression of ABCA1 mRNA]
Linoleic Acid results in increased phosphorylation of ABCA1 protein		 CTD PMID:16118212, PMID:18356535, PMID:27939595 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015 		JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 decreases expression ISO Linoleic Acid results in decreased expression of ABCG1 mRNA; Linoleic Acid results in decreased expression of ABCG1 protein CTD PMID:16730733 NCBI chr20:9,743,269...9,842,735
Ensembl chr20:9,743,269...9,840,489 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha decreases expression EXP Linoleic Acid results in decreased expression of ACACA mRNA CTD PMID:14563831 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910 		JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain increases expression EXP Linoleic Acid results in increased expression of ACADM mRNA CTD PMID:23056435 NCBI chr 2:260,124,418...260,148,589
Ensembl chr 2:260,124,418...260,148,589 		JBrowse link
G Acly ATP citrate lyase decreases expression EXP Linoleic Acid results in decreased expression of ACLY mRNA CTD PMID:14563831 NCBI chr10:88,392,248...88,442,845
Ensembl chr10:88,392,248...88,442,845 		JBrowse link
G Acmsd aminocarboxymuconate semialdehyde decarboxylase decreases expression EXP Linoleic Acid results in decreased expression of ACMSD mRNA CTD PMID:18320257 NCBI chr13:44,424,689...44,468,734
Ensembl chr13:44,424,689...44,468,734 		JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression EXP Linoleic Acid results in increased expression of ACOX1 mRNA CTD PMID:18320257 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing decreases expression ISO Linoleic Acid results in decreased expression of ADIPOQ mRNA CTD PMID:17374693 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488 		JBrowse link
G Adipor1 adiponectin receptor 1 increases expression ISO Linoleic Acid analog results in increased expression of ADIPOR1 mRNA CTD PMID:27939595 NCBI chr13:51,240,470...51,260,233
Ensembl chr13:51,240,911...51,260,228 		JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions EXP AGER protein results in increased susceptibility to [Azoxymethane co-treated with Glucose co-treated with Linoleic Acid]; Glucose promotes the reaction [Linoleic Acid promotes the reaction [Azoxymethane results in increased expression of AGER protein]]; Linoleic Acid promotes the reaction [Azoxymethane results in increased expression of AGER protein]; Linoleic Acid promotes the reaction [Glucose promotes the reaction [Azoxymethane results in increased expression of AGER protein]]; Losartan inhibits the reaction [Glucose promotes the reaction [Linoleic Acid promotes the reaction [Azoxymethane results in increased expression of AGER protein]]]; Losartan inhibits the reaction [Linoleic Acid promotes the reaction [Glucose promotes the reaction [Azoxymethane results in increased expression of AGER protein]]]; Metformin inhibits the reaction [Glucose promotes the reaction [Linoleic Acid promotes the reaction [Azoxymethane results in increased expression of AGER protein]]]; Metformin inhibits the reaction [Linoleic Acid promotes the reaction [Glucose promotes the reaction [Azoxymethane results in increased expression of AGER protein]]] CTD PMID:22467055 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO Linoleic Acid inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 promoter]]; Linoleic Acid inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PTGS2 promoter]] CTD PMID:18001219 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase increases oxidation ISO ALOX15 protein results in increased oxidation of Linoleic Acid CTD PMID:25786526 NCBI chr10:56,953,692...56,962,145
Ensembl chr10:56,953,691...56,962,161 		JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]; Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Phospholipids]]; PLD2 protein inhibits the reaction [Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]]] CTD PMID:16118212 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875 		JBrowse link
G Ascl2 achaete-scute family bHLH transcription factor 2 decreases expression ISO Linoleic Acid results in decreased expression of ASCL2 mRNA CTD PMID:15708366 NCBI chr 1:216,154,002...216,156,409
Ensembl chr 1:216,154,002...216,156,409 		JBrowse link
G Bche butyrylcholinesterase increases expression ISO Linoleic Acid results in increased expression of BCHE mRNA CTD PMID:27106529 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP [Linoleic Acid co-treated with Glucose] affects the reaction [Azoxymethane affects the expression of BCL2 protein]; Linoleic Acid affects the reaction [Azoxymethane affects the expression of BCL2 protein] CTD PMID:22467055 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Cat catalase increases expression ISO Linoleic Acid results in increased expression of CAT protein CTD PMID:10946007 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Linoleic Acid results in increased expression of CCL2 protein CTD PMID:16305726 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Cd36 CD36 molecule multiple interactions EXP [Oleic Acid co-treated with Linoleic Acid] results in increased expression of CD36 mRNA CTD PMID:28552552 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749 		JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions
affects response to substance		 ISO CNR1 protein affects the reaction [Linoleic Acid results in increased secretion of GCG protein]
CNR1 protein affects the susceptibility to Linoleic Acid		 CTD PMID:30241419 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056 		JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO Linoleic Acid results in increased expression of COL1A1 mRNA CTD PMID:26240151 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789 		JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression ISO Linoleic Acid results in decreased expression of COL3A1 mRNA CTD PMID:26240151 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression EXP Linoleic Acid results in increased expression of CPT1A mRNA CTD PMID:11171094 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678 		JBrowse link
G Crebbp CREB binding protein multiple interactions ISO Linoleic Acid affects the reaction [PPARA protein binds to CREBBP protein] CTD PMID:19263263 NCBI chr10:11,590,994...11,721,039
Ensembl chr10:11,595,044...11,721,039 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO [Oleic Acid co-treated with Linoleic Acid] results in increased expression of CYCS protein CTD PMID:27016407 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Linoleic Acid inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 promoter]] CTD PMID:18001219 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO Linoleic Acid results in decreased activity of CYP1A2 protein CTD PMID:16978661 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions
decreases activity		 ISO CYP2C19 protein results in increased metabolism of [Linoleic Acid co-treated with NADP]
Linoleic Acid results in decreased activity of CYP2C19 protein		 CTD PMID:16978661 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO Linoleic Acid results in decreased activity of CYP2E1 protein CTD PMID:16978661 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Linoleic Acid analog results in increased expression of DDIT3 protein CTD PMID:27939595 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084 		JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases activity ISO Linoleic Acid results in decreased activity of DIO1 protein CTD PMID:30561685 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520 		JBrowse link
G Dio2 iodothyronine deiodinase 2 decreases activity ISO Linoleic Acid results in decreased activity of DIO2 protein CTD PMID:30561685 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723 		JBrowse link
G Dio3 iodothyronine deiodinase 3 decreases activity ISO Linoleic Acid results in decreased activity of DIO3 protein CTD PMID:30561685 NCBI chr 6:134,627,278...134,629,139
Ensembl chr 6:134,627,278...134,629,138 		JBrowse link
G Edn1 endothelin 1 decreases expression ISO Linoleic Acid results in decreased expression of EDN1 mRNA; Linoleic Acid results in decreased expression of EDN1 protein CTD PMID:16895544 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324 		JBrowse link
G Fabp1 fatty acid binding protein 1 decreases expression ISO Linoleic Acid results in decreased expression of FABP1 mRNA CTD PMID:15708366 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954 		JBrowse link
G Fabp3 fatty acid binding protein 3 decreases expression ISO Linoleic Acid results in decreased expression of FABP3 mRNA CTD PMID:15708366 NCBI chr 5:148,528,854...148,535,597
Ensembl chr 5:148,528,725...148,535,565 		JBrowse link
G Fabp4 fatty acid binding protein 4 affects localization ISO Linoleic Acid analog affects the localization of FABP4 protein CTD PMID:27939595 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305 		JBrowse link
G Fads2 fatty acid desaturase 2 multiple interactions
increases expression		 ISO [Linoleic Acid co-treated with Testosterone] results in increased expression of FADS2 mRNA
FADS2 protein inhibits the reaction [Linoleic Acid results in increased activity of LOX protein]
Linoleic Acid results in increased expression of FADS2 mRNA; Linoleic Acid results in increased expression of FADS2 protein		 CTD PMID:21457203, PMID:26240151 NCBI chr 1:225,906,582...226,152,568
Ensembl chr 1:226,114,413...226,152,524 		JBrowse link
G Fasn fatty acid synthase decreases expression EXP Linoleic Acid results in decreased expression of FASN mRNA CTD PMID:14563831 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901 		JBrowse link
G Ffar3 free fatty acid receptor 3 increases expression ISO Linoleic Acid analog results in increased expression of FFAR3 mRNA CTD PMID:27939595 NCBI chr 1:89,302,035...89,304,064
Ensembl chr 1:89,302,039...89,303,968 		JBrowse link
G Foxo1 forkhead box O1 decreases expression ISO Linoleic Acid results in decreased expression of FOXO1 protein CTD PMID:17374693 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016 		JBrowse link
G Gcg glucagon multiple interactions ISO CNR1 protein affects the reaction [Linoleic Acid results in increased secretion of GCG protein] CTD PMID:30241419 NCBI chr 3:48,442,635...48,451,650
Ensembl chr 3:48,442,635...48,451,650 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Linoleic Acid metabolite results in increased expression of GCLM mRNA CTD PMID:26879219 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874 		JBrowse link
G Gjb1 gap junction protein, beta 1 increases abundance ISO GJB1 protein results in increased abundance of Linoleic Acid CTD PMID:27859493 NCBI chr  X:71,272,030...71,279,973
Ensembl chr  X:71,272,042...71,279,977 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 increases expression
multiple interactions		 ISO Linoleic Acid results in increased expression of GSTA1 mRNA
NFE2L2 protein promotes the reaction [Linoleic Acid results in increased expression of GSTA1 mRNA]		 CTD PMID:28555106 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO NFE2L2 mRNA promotes the reaction [Linoleic Acid metabolite results in increased expression of HMOX1 mRNA]
Linoleic Acid metabolite results in increased expression of HMOX1 mRNA; Linoleic Acid metabolite results in increased expression of HMOX1 protein		 CTD PMID:26879219 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Linoleic Acid analog results in increased expression of HSPA5 protein CTD PMID:27939595 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762 		JBrowse link
G Ifng interferon gamma increases expression ISO Linoleic Acid results in increased expression of IFNG protein CTD PMID:16305726 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Il10 interleukin 10 increases expression ISO Linoleic Acid results in increased expression of IL10 protein CTD PMID:16305726 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392 		JBrowse link
G Il1b interleukin 1 beta increases expression ISO Linoleic Acid results in increased expression of IL1B protein CTD PMID:16305726 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il2 interleukin 2 decreases expression ISO Linoleic Acid results in decreased expression of IL2 protein CTD PMID:16305726 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854 		JBrowse link
G Il4 interleukin 4 decreases expression ISO Linoleic Acid results in decreased expression of IL4 protein CTD PMID:16305726 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531 		JBrowse link
G Il5 interleukin 5 decreases expression ISO Linoleic Acid results in decreased expression of IL5 protein CTD PMID:16305726 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587 		JBrowse link
G Il6 interleukin 6 affects expression
increases expression
increases secretion		 ISO Linoleic Acid affects the expression of IL6 protein
Linoleic Acid results in increased expression of IL6 mRNA
Linoleic Acid results in increased secretion of IL6 protein		 CTD PMID:16305726, PMID:17374693, PMID:21457203 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Insr insulin receptor increases expression ISO Linoleic Acid analog results in increased expression of INSR mRNA CTD PMID:27939595 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414 		JBrowse link
G Lcat lecithin cholesterol acyltransferase increases expression ISO Linoleic Acid analog results in increased expression of LCAT mRNA CTD PMID:27939595 NCBI chr19:37,913,333...37,916,799
Ensembl chr19:37,913,336...37,916,813 		JBrowse link
G Lipc lipase C, hepatic type multiple interactions ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in decreased abundance of Linoleic Acid CTD PMID:24777581 NCBI chr 8:77,272,582...77,398,485
Ensembl chr 8:77,272,570...77,398,248 		JBrowse link
G Lipg lipase G, endothelial type multiple interactions ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in decreased abundance of Linoleic Acid CTD PMID:24777581 NCBI chr18:70,903,528...70,924,434
Ensembl chr18:70,901,710...70,924,708 		JBrowse link
G Lox lysyl oxidase multiple interactions
increases activity		 ISO FADS2 protein inhibits the reaction [Linoleic Acid results in increased activity of LOX protein]; TGFB1 protein promotes the reaction [Linoleic Acid results in increased activity of LOX protein] CTD PMID:26240151 NCBI chr18:47,500,320...47,577,819
Ensembl chr18:47,500,330...47,577,819 		JBrowse link
G Lpin1 lipin 1 decreases expression ISO Linoleic Acid analog results in decreased expression of LPIN1 mRNA CTD PMID:27939595 NCBI chr 6:41,796,214...41,905,149
Ensembl chr 6:41,799,749...41,870,046 		JBrowse link
G Lrat lecithin retinol acyltransferase increases expression EXP Linoleic Acid results in increased expression of LRAT mRNA CTD PMID:12576510 NCBI chr 2:181,896,304...181,905,366
Ensembl chr 2:181,896,305...181,905,300 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Linoleic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:23288142 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression		 ISO
EXP		 Linoleic Acid results in decreased expression of and results in decreased activity of MMP9 protein
[Linoleic Acid co-treated with Glucose] affects the reaction [Azoxymethane affects the expression of MMP9 protein]; Linoleic Acid affects the reaction [Azoxymethane affects the expression of MMP9 protein]
Linoleic Acid results in decreased expression of MMP9 mRNA		 CTD PMID:22467055, PMID:23288142 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO Linoleic Acid affects the reaction [Zymosan analog affects the localization of NCF1 protein] CTD PMID:12101222 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300 		JBrowse link
G Ncf2 neutrophil cytosolic factor 2 multiple interactions ISO Linoleic Acid affects the reaction [Zymosan analog affects the localization of NCF2 protein] CTD PMID:12101222 NCBI chr13:70,226,441...70,259,019
Ensembl chr13:70,226,647...70,257,576 		JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO Linoleic Acid promotes the reaction [PPARA protein binds to NCOA1 protein] CTD PMID:19263263 NCBI chr 6:28,677,563...28,931,844
Ensembl chr 6:28,677,540...28,931,843 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO Linoleic Acid promotes the reaction [PPARA protein binds to NCOA2 protein] CTD PMID:19263263 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression
multiple interactions		 ISO Linoleic Acid metabolite results in increased expression of NFE2L2 protein; Linoleic Acid results in increased expression of NFE2L2 mRNA; Linoleic Acid results in increased expression of NFE2L2 protein
NFE2L2 mRNA promotes the reaction [Linoleic Acid metabolite results in increased expression of HMOX1 mRNA]; NFE2L2 protein promotes the reaction [Linoleic Acid results in increased expression of CYP2A6 mRNA]; NFE2L2 protein promotes the reaction [Linoleic Acid results in increased expression of CYP2A6 protein]; NFE2L2 protein promotes the reaction [Linoleic Acid results in increased expression of GSTA1 mRNA]		 CTD PMID:26879219, PMID:28555106 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP [Linoleic Acid co-treated with Glucose] affects the reaction [Azoxymethane affects the expression of NOS2 protein]; Linoleic Acid affects the reaction [Azoxymethane affects the expression of NOS2 protein] CTD PMID:22467055 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nos3 nitric oxide synthase 3 decreases expression ISO Linoleic Acid results in decreased expression of NOS3 mRNA CTD PMID:16895544 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO Linoleic Acid metabolite results in increased expression of NQO1 mRNA CTD PMID:26879219 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 multiple interactions ISO [NR5A2 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of Linoleic Acid analog CTD PMID:29515023 NCBI chr13:53,750,470...53,870,288
Ensembl chr13:53,750,473...53,870,428 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions ISO [Glucose deficiency co-treated with Linoleic Acid] results in increased expression of PCK1 mRNA CTD PMID:8536680 NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 increases expression EXP Linoleic Acid results in increased expression of PDK4 mRNA CTD PMID:23056435 NCBI chr 4:30,546,772...30,556,774
Ensembl chr 4:30,546,664...30,556,814 		JBrowse link
G Pld2 phospholipase D2 multiple interactions ISO PLD2 protein inhibits the reaction [Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]]] CTD PMID:16118212 NCBI chr10:57,161,921...57,181,148
Ensembl chr10:57,163,174...57,179,730 		JBrowse link
G Plin1 perilipin 1 increases expression ISO Linoleic Acid analog results in increased expression of PLIN1 mRNA CTD PMID:27939595 NCBI chr 1:141,458,907...141,470,927
Ensembl chr 1:141,458,181...141,471,010 		JBrowse link
G Pon1 paraoxonase 1 multiple interactions
decreases activity		 ISO Linoleic Acid inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; Linoleic Acid inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid]
Linoleic Acid results in decreased activity of PON1 protein		 CTD PMID:12871208, PMID:15375178 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
increases expression
affects abundance
increases activity
affects binding		 ISO
EXP		 [Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased oxidation of Linoleic Acid; Linoleic Acid affects the reaction [PPARA protein binds to CREBBP protein]; Linoleic Acid binds to and results in increased activity of PPARA protein; Linoleic Acid promotes the reaction [PPARA protein binds to NCOA1 protein]; Linoleic Acid promotes the reaction [PPARA protein binds to NCOA2 protein]
Linoleic Acid results in increased expression of PPARA mRNA
PPARA protein affects the abundance of Linoleic Acid
Diethylhexyl Phthalate inhibits the reaction [PPARA protein affects the abundance of Linoleic Acid]; Linoleic Acid binds to and results in increased activity of PPARA protein
Linoleic Acid results in increased expression of PPARA mRNA; Linoleic Acid results in increased expression of PPARA protein
Linoleic Acid results in increased activity of PPARA protein
Linoleic Acid binds to PPARA protein		 CTD PMID:10403814, PMID:11172467, PMID:15491415, PMID:16731579, PMID:18154422, PMID:19263263, PMID:20404010, PMID:23056435, PMID:23619606, PMID:23843199, PMID:25786526 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions
decreases expression
increases expression
increases activity
affects binding		 ISO
EXP		 Linoleic Acid binds to and results in increased activity of PPARB protein
Linoleic Acid results in decreased expression of PPARD mRNA
Linoleic Acid results in increased expression of PPARD mRNA
Linoleic Acid results in increased activity of PPARD protein
Linoleic Acid binds to PPARB protein		 CTD PMID:11172467, PMID:15708366, PMID:16731579, PMID:23843199, PMID:25786526 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects binding
multiple interactions
increases expression
increases activity
decreases expression		 ISO
EXP		 Linoleic Acid binds to PPARG protein
Linoleic Acid binds to and results in increased activity of PPARG protein
Linoleic Acid results in increased expression of PPARG mRNA
resveratrol inhibits the reaction [Linoleic Acid results in increased expression of PPARG protein]
Linoleic Acid results in increased activity of PPARG protein
Linoleic Acid results in decreased expression of PPARG mRNA; Linoleic Acid results in decreased expression of PPARG protein		 CTD PMID:11172467, PMID:12021203, PMID:15708366, PMID:16731579, PMID:18154422, PMID:23843199, PMID:25672876, PMID:25786526 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression EXP
ISO		 Linoleic Acid results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009 		JBrowse link
G Ppargc1b PPARG coactivator 1 beta increases expression EXP Linoleic Acid results in increased expression of PPARGC1B mRNA CTD PMID:23056435 NCBI chr18:56,626,725...56,650,524
Ensembl chr18:56,626,712...56,728,968 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions		 EXP
ISO		 Linoleic Acid results in increased expression of PTGS2 mRNA
Linoleic Acid inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGS2 mRNA]; Linoleic Acid inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PTGS2 promoter]]; Linoleic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]		 CTD PMID:14563831, PMID:18001219 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Rxra retinoid X receptor alpha affects binding
multiple interactions		 ISO Linoleic Acid binds to RXRA protein
Linoleic Acid binds to and results in increased activity of RXRA protein		 CTD PMID:16258897, PMID:16731579 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908 		JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions
increases expression		 ISO [Linoleic Acid co-treated with Testosterone] results in increased expression of SCD mRNA
Linoleic Acid results in increased expression of SCD mRNA; Linoleic Acid results in increased expression of SCD protein		 CTD PMID:21457203 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729 		JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO Linoleic Acid results in increased expression of SERPINE1 mRNA CTD PMID:17374693 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases activity ISO Linoleic Acid results in decreased activity of SLC22A6 protein CTD PMID:29045746 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 decreases activity ISO Linoleic Acid results in decreased activity of SLC22A8 protein CTD PMID:29045746 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482 		JBrowse link
G Smad3 SMAD family member 3 decreases abundance ISO SMAD3 protein results in decreased abundance of Linoleic Acid CTD PMID:23034213 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression EXP Linoleic Acid results in decreased expression of SREBF1 mRNA CTD PMID:14563831 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO TGFB1 protein promotes the reaction [Linoleic Acid results in increased activity of LOX protein] CTD PMID:26240151 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Tnf tumor necrosis factor decreases response to substance ISO Linoleic Acid results in decreased susceptibility to TNF protein CTD PMID:22683933 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions ISO TRPV1 results in increased susceptibility to [Linoleic Acid co-treated with Freund's Adjuvant] CTD PMID:23006841 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679 		JBrowse link
G Ucp2 uncoupling protein 2 increases expression EXP Linoleic Acid results in increased expression of UCP2 mRNA CTD PMID:11341955 NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP [Linoleic Acid co-treated with Glucose] affects the reaction [Azoxymethane affects the expression of VEGFA protein] CTD PMID:22467055 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
G Wnt10b Wnt family member 10B decreases expression ISO Linoleic Acid results in decreased expression of WNT10B mRNA CTD PMID:12021203 NCBI chr 7:140,448,284...140,466,159
Ensembl chr 7:140,448,465...140,454,268 		JBrowse link
1,2,3-trilinoleoylglycerol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 decreases expression ISO trilinolein results in decreased expression of ABCA1 mRNA CTD PMID:18356535 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015 		JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 decreases expression ISO trilinolein results in decreased expression of ABCG5 mRNA CTD PMID:18356535 NCBI chr 6:7,935,771...7,961,207
Ensembl chr 6:7,935,771...7,961,207 		JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 decreases expression ISO trilinolein results in decreased expression of ABCG8 mRNA CTD PMID:18356535 NCBI chr 6:7,961,413...7,980,708
Ensembl chr 6:7,961,413...7,980,708 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases expression ISO trilinolein results in decreased expression of CYP27A1 mRNA CTD PMID:18356535 NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression ISO trilinolein results in increased expression of HMGCR mRNA CTD PMID:18356535 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654 		JBrowse link
G Mttp microsomal triglyceride transfer protein increases expression ISO trilinolein results in increased expression of MTTP mRNA CTD PMID:18356535 NCBI chr 2:243,366,181...243,407,608
Ensembl chr 2:243,366,181...243,407,608 		JBrowse link
G Npc1l1 NPC1 like intracellular cholesterol transporter 1 decreases expression ISO trilinolein results in decreased expression of NPC1L1 mRNA CTD PMID:18356535 NCBI chr14:86,345,946...86,560,694
Ensembl chr14:86,345,953...86,560,694 		JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions
decreases expression		 ISO Clofibrate inhibits the reaction [trilinolein results in decreased expression of SCD1 mRNA] CTD PMID:8790349 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729 		JBrowse link
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fech ferrochelatase affects abundance ISO FECH protein affects the abundance of 1-palmitoyl-2-linoleoylphosphatidylcholine CTD PMID:29906468 NCBI chr18:59,941,992...59,975,192
Ensembl chr18:59,941,992...59,975,192 		JBrowse link
1-stearoyl-2-linoleoyl-sn-glycerol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lipc lipase C, hepatic type decreases abundance ISO LIPC gene mutant form results in decreased abundance of 1-stearoyl-2-linoleoyl-sn-glycerol CTD PMID:24777581 NCBI chr 8:77,272,582...77,398,485
Ensembl chr 8:77,272,570...77,398,248 		JBrowse link
G Lipg lipase G, endothelial type decreases abundance ISO LIPG gene mutant form results in decreased abundance of 1-stearoyl-2-linoleoyl-sn-glycerol CTD PMID:24777581 NCBI chr18:70,903,528...70,924,434
Ensembl chr18:70,901,710...70,924,708 		JBrowse link
13-HPODE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase increases expression ISO 13-hydroperoxy-9,11-octadecadienoic acid results in increased expression of CAT protein CTD PMID:10946007 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Cav1 caveolin 1 increases expression ISO 13-hydroperoxy-9,11-octadecadienoic acid results in increased expression of CAV1 mRNA CTD PMID:27257344 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP [13-hydroperoxy-9,11-octadecadienoic acid co-treated with 2-chloro-5-nitrobenzanilide] results in increased expression of CCL2 mRNA; [13-hydroperoxy-9,11-octadecadienoic acid co-treated with 2-chloro-5-nitrobenzanilide] results in increased expression of CCL2 protein; [13-hydroperoxy-9,11-octadecadienoic acid co-treated with MK-886] results in increased expression of CCL2 mRNA; [13-hydroperoxy-9,11-octadecadienoic acid co-treated with MK-886] results in increased expression of CCL2 protein CTD PMID:22135674 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Egr1 early growth response 1 multiple interactions EXP [13-hydroperoxy-9,11-octadecadienoic acid co-treated with 2-chloro-5-nitrobenzanilide] results in increased expression of EGR1 mRNA; [13-hydroperoxy-9,11-octadecadienoic acid co-treated with 2-chloro-5-nitrobenzanilide] results in increased expression of EGR1 protein; [13-hydroperoxy-9,11-octadecadienoic acid co-treated with MK-886] results in increased expression of EGR1 mRNA; [13-hydroperoxy-9,11-octadecadienoic acid co-treated with MK-886] results in increased expression of EGR1 protein CTD PMID:22135674 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression EXP 13-hydroperoxy-9,11-octadecadienoic acid results in increased expression of PPARA protein CTD PMID:22135674 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression EXP 13-hydroperoxy-9,11-octadecadienoic acid results in increased expression of PPARG protein CTD PMID:22135674 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
cholesteryl linoleate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lipc lipase C, hepatic type multiple interactions ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of cholesteryl linoleate CTD PMID:24777581 NCBI chr 8:77,272,582...77,398,485
Ensembl chr 8:77,272,570...77,398,248 		JBrowse link
G Lipg lipase G, endothelial type multiple interactions
affects abundance		 ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of cholesteryl linoleate
LIPG gene mutant form affects the abundance of cholesteryl linoleate		 CTD PMID:24777581 NCBI chr18:70,903,528...70,924,434
Ensembl chr18:70,901,710...70,924,708 		JBrowse link
linoleamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pparg peroxisome proliferator-activated receptor gamma increases activity ISO linoleamide analog results in increased activity of PPARG protein CTD PMID:29288688 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
linoleic acid hydroperoxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions
increases lipidation		 ISO Ascorbic Acid promotes the reaction [linoleic acid hydroperoxide results in increased lipidation of AGT protein modified form] CTD PMID:26111765 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433 		JBrowse link
G Cygb cytoglobin increases metabolic processing EXP CYGB protein results in increased metabolism of linoleic acid hydroperoxide CTD PMID:11320098 NCBI chr10:105,618,325...105,628,091
Ensembl chr10:105,618,326...105,628,091 		JBrowse link
G Gpx1 glutathione peroxidase 1 increases reduction ISO GPX1 protein results in increased reduction of linoleic acid hydroperoxide CTD PMID:8428933 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522 		JBrowse link
G Gpx2 glutathione peroxidase 2 increases reduction ISO GPX2 protein results in increased reduction of linoleic acid hydroperoxide CTD PMID:8428933 NCBI chr 6:99,839,960...99,843,245
Ensembl chr 6:99,839,960...99,843,245 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      biological role 19758
        biochemical role 19304
          metabolite 19285
            eukaryotic metabolite 18934
              plant metabolite 17422
                linoleic acid 109
                  (11S)-11-hydroperoxylinoleic acid 0
                  (24S)-24-hydroxycholesterol 3-linoleoate 0
                  (9S),10-epoxy-(10,12Z)-octadecadienoic acid 0
                  (9Z,12Z)-11-hydroxyoctadecadienoic acid 0
                  1,1',2-trilinoleoyl-2'-oleoyl cardiolipin 0
                  1,1',2-trilinoleoyl-2'-palmitoyl cardiolipin 0
                  1,1'-dilinoleoyl-2-oleoyl monolysocardiolipin 0
                  1,2,2'-trilinoleoyl-,1'-monolysocardiolipin 0
                  1,2,3-trilinoleoylglycerol 8
                  1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine 0
                  1,2-di-[(9Z,12Z)-octadecadienoyl]-sn-glycero-3-phosphocholine 0
                  1,2-dilinoleoyl-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol 0
                  1,2-dilinoleoyl-sn-glycero-3-phospho-1D-myo-inositol 0
                  1,2-dilinoleoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate 0
                  1,2-dilinoleoyl-sn-glycerol 0
                  1,2-dioleoyl-3-linoleoyl-sn-glycerol 0
                  1,3-dilinoleoylglycerol 0
                  1-(1Z,11Z-octadecadienyl)-2-linoleoyl-sn-glycero-3-phosphoethanolamine 0
                  1-(1Z-hexadecenyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine 0
                  1-(1Z-hexadecenyl)-2-linoleoyl-sn-glycero-3-phosphoethanolamine 0
                  1-(1Z-octadecenyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine 0
                  1-(1Z-octadecenyl)-2-linoleoyl-sn-glycero-3-phosphoethanolamine 0
                  1-O-linoleoyl-N-acetylsphingosine 0
                  1-[(10Z,13Z,16Z)-docosatrienoyl]-2-linoleoyl-sn-glycero-3-phospho-1D-myo-inositol 0
                  1-[(13Z,16Z)-docosadienoyl]-2-linoleoyl-sn-glycero-3-phospho-1D-myo-inositol 0
                  1-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-2-[(9Z,12Z)-octadecadienoyl]-sn-glycero-3-phosphocholine 0
                  1-[(9Z,12Z)-octadecadienoyl]-2-[(5Z,8Z,11Z,14Z)-icosatetraenoyl]-sn-glycero-3-phosphocholine 0
                  1-[(9Z,12Z)-octadecadienoyl]-2-hexadecanoyl-sn-glycero-3-phosphocholine 0
                  1-[(9Z,12Z)-octadecadienoyl]-2-icosanoyl-sn-glycerol 0
                  1-[(9Z,12Z)-octadecadienoyl]-2-octadecanoyl-sn-glycero-3-phosphocholine 0
                  1-[(9Z,12Z)-octadecadienoyl]-2-octadecanoyl-sn-glycerol 0
                  1-acyl-2-linoleoyl-sn-glycero-3-phosphate + 0
                  1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine betaine + 1
                  1-acyl-2-linoleoyl-sn-glycero-3-phosphoethanolamine zwitterion + 0
                  1-eicosyl-2-linolenyl-sn-glycero-3-phosphoethanolamine 0
                  1-heptadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine 0
                  1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine 0
                  1-hexadecyl-2-[(9Z,12Z)-octadecadienoyl]-sn-glycero-3-phosphocholine 0
                  1-icosyl-2-[(9Z,12Z)-octadecadienoyl]-sn-glycero-3-phosphocholine 0
                  1-linolenyl-2-linoleyl-PAP 0
                  1-linoleoyl-2-oleoyl-sn-glycero-3-phosphate 0
                  1-linoleoyl-2-oleoylglycerol + 0
                  1-linoleoyl-sn-glycero-3-phospho-D-myo-inositol 0
                  1-linoleoyl-sn-glycero-3-phosphocholine 0
                  1-linoleoyl-sn-glycero-3-phosphoethanolamine 0
                  1-linoleoylglycerone 3-phosphate 0
                  1-monolinolein + 0
                  1-myristoyl-2-linoleoyl-sn-glycerol 0
                  1-octadecanoyl-2-[(9Z,12Z)-octadecadienoyl]-sn-glycero-3-phosphocholine 0
                  1-oleoyl-2,3-di-linoleoyl-sn-glycerol 0
                  1-oleoyl-2-linoleoyl-sn-glycero-3-phosphate 0
                  1-oleoyl-2-linoleoyl-sn-glycero-3-phospho-L-serine 0
                  1-oleoyl-2-linoleoyl-sn-glycerol 0
                  1-oleoyl-2-linoleyl-sn-glycero-3-phosphoethanolamine 0
                  1-oleoyl-3-linoleoylglycerol 0
                  1-oleyl-2-linoleyl-PAP 0
                  1-palmitoleoyl-2-linoleoyl-sn-glycero-3-phosphocholine 0
                  1-palmitoleoyl-2-linoleoyl-sn-glycerol 0
                  1-palmitoyl-2-linoleoyl-sn-glycerol 0
                  1-palmitoyl-3-linoleoylglycerol 0
                  1-palmityl-2-acetyl-3-linoleoyl-sn-glycerol 0
                  1-pentadecanoyl-2-linoleoyl-sn-glycero-3-phosphocholine 0
                  1-stearoyl-2-linoleoyl-sn-glycero-3-phospho-1D-myo-inositol 0
                  1-stearoyl-2-linoleoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate 0
                  1-stearoyl-2-linoleoyl-sn-glycero-3-phospho-L-serine 0
                  1-stearoyl-2-linoleoyl-sn-glycero-3-phosphoethanolamine 0
                  1-stearoyl-2-linoleoyl-sn-glycerol 2
                  1-tetradecanoyl-2-[(9Z,12Z)-octadecadienoyl]-sn-glycero-3-phosphocholine 0
                  12,13-epoxy-18-hydroxy-(9Z)-octadecenoic acid 0
                  13-hydroperoxylinoleic acid 0
                  18-hydroxylinoleic acid 0
                  2,3-dilinoleoyl-sn-glycerol 0
                  2-hydroxylinoleic acid 0
                  2-linoleoyl-sn-glycero-3-phosphocholine 0
                  2-linoleoyl-sn-glycero-3-phosphoethanolamine 0
                  2-linoleoyl-sn-glycero-3-phosphoethanolamine zwitterion 0
                  2-linoleoylglycerol 0
                  5(S),8(R)-DiHODE 0
                  7(S),8(S)-DiHODE 0
                  7-demethoxyegonol-9(Z),12(Z)linoleate 0
                  8(R)-HPODE 0
                  9,10-epoxy-18-hydroxy-(12Z)-octadecenoic acid 0
                  CDP-1,2-dilinoleoyl-sn-glycerol 0
                  CDP-1-stearoyl-2-linoleoyl-sn-glycerol 0
                  HPODE + 10
                  N,1-dipalmitoyl-2-linoleoyl-sn-glycero-3-phosphoethanolamine 0
                  N-butyryl-1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphoethanolamine 0
                  N-caproyl-1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphoethanolamine 0
                  N-capryl-1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphoethanolamine 0
                  N-capryloyl-1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphoethanolamine 0
                  O-linoleyl-L-carnitine 0
                  all-trans-retinyl linoleate 0
                  cholesteryl linoleate 2
                  dilinoleoylglycerol + 0
                  egonol-9(Z),12(Z)linoleate + 0
                  ethyl linoleate 0
                  laetisaric acid 0
                  linoleamide 1
                  linoleic acid hydroperoxide + 4
                  linoleoyl bioconjugate + 0
                  linoleoyl ethanolamide 0
                  linoleoyl group 0
                  linoleoyl-containing glycerolipid 0
                  linoleoyl-sn-glycero-3-phosphocholine + 0
                  linoleylanilide 0
                  methyl linoleate + 0
                  propyl linoleate 0
                  tetralinoleoyl cardiolipin 0
                  trilinoleoyl 2-monolysocardiolipin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic group 18527
                              organic divalent group 18520
                                organodiyl group 18520
                                  carbonyl group 18427
                                    carbonyl compound 18427
                                      carboxylic acid 18108
                                        monocarboxylic acid 17475
                                          fatty acid 15994
                                            unsaturated fatty acid 924
                                              polyunsaturated fatty acid 664
                                                essential fatty acid 379
                                                  omega-6 fatty acid 372
                                                    linoleic acid 109
                                                      (11S)-11-hydroperoxylinoleic acid 0
                                                      (24S)-24-hydroxycholesterol 3-linoleoate 0
                                                      (9S),10-epoxy-(10,12Z)-octadecadienoic acid 0
                                                      (9Z,12Z)-11-hydroxyoctadecadienoic acid 0
                                                      1,1',2-trilinoleoyl-2'-oleoyl cardiolipin 0
                                                      1,1',2-trilinoleoyl-2'-palmitoyl cardiolipin 0
                                                      1,1'-dilinoleoyl-2-oleoyl monolysocardiolipin 0
                                                      1,2,2'-trilinoleoyl-,1'-monolysocardiolipin 0
                                                      1,2,3-trilinoleoylglycerol 8
                                                      1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine 0
                                                      1,2-di-[(9Z,12Z)-octadecadienoyl]-sn-glycero-3-phosphocholine 0
                                                      1,2-dilinoleoyl-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol 0
                                                      1,2-dilinoleoyl-sn-glycero-3-phospho-1D-myo-inositol 0
                                                      1,2-dilinoleoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate 0
                                                      1,2-dilinoleoyl-sn-glycerol 0
                                                      1,2-dioleoyl-3-linoleoyl-sn-glycerol 0
                                                      1,3-dilinoleoylglycerol 0
                                                      1-(1Z,11Z-octadecadienyl)-2-linoleoyl-sn-glycero-3-phosphoethanolamine 0
                                                      1-(1Z-hexadecenyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine 0
                                                      1-(1Z-hexadecenyl)-2-linoleoyl-sn-glycero-3-phosphoethanolamine 0
                                                      1-(1Z-octadecenyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine 0
                                                      1-(1Z-octadecenyl)-2-linoleoyl-sn-glycero-3-phosphoethanolamine 0
                                                      1-O-linoleoyl-N-acetylsphingosine 0
                                                      1-[(10Z,13Z,16Z)-docosatrienoyl]-2-linoleoyl-sn-glycero-3-phospho-1D-myo-inositol 0
                                                      1-[(13Z,16Z)-docosadienoyl]-2-linoleoyl-sn-glycero-3-phospho-1D-myo-inositol 0
                                                      1-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-2-[(9Z,12Z)-octadecadienoyl]-sn-glycero-3-phosphocholine 0
                                                      1-[(9Z,12Z)-octadecadienoyl]-2-[(5Z,8Z,11Z,14Z)-icosatetraenoyl]-sn-glycero-3-phosphocholine 0
                                                      1-[(9Z,12Z)-octadecadienoyl]-2-hexadecanoyl-sn-glycero-3-phosphocholine 0
                                                      1-[(9Z,12Z)-octadecadienoyl]-2-icosanoyl-sn-glycerol 0
                                                      1-[(9Z,12Z)-octadecadienoyl]-2-octadecanoyl-sn-glycero-3-phosphocholine 0
                                                      1-[(9Z,12Z)-octadecadienoyl]-2-octadecanoyl-sn-glycerol 0
                                                      1-acyl-2-linoleoyl-sn-glycero-3-phosphate + 0
                                                      1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine betaine + 1
                                                      1-acyl-2-linoleoyl-sn-glycero-3-phosphoethanolamine zwitterion + 0
                                                      1-eicosyl-2-linolenyl-sn-glycero-3-phosphoethanolamine 0
                                                      1-heptadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine 0
                                                      1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine 0
                                                      1-hexadecyl-2-[(9Z,12Z)-octadecadienoyl]-sn-glycero-3-phosphocholine 0
                                                      1-icosyl-2-[(9Z,12Z)-octadecadienoyl]-sn-glycero-3-phosphocholine 0
                                                      1-linolenyl-2-linoleyl-PAP 0
                                                      1-linoleoyl-2-oleoyl-sn-glycero-3-phosphate 0
                                                      1-linoleoyl-2-oleoylglycerol + 0
                                                      1-linoleoyl-sn-glycero-3-phospho-D-myo-inositol 0
                                                      1-linoleoyl-sn-glycero-3-phosphocholine 0
                                                      1-linoleoyl-sn-glycero-3-phosphoethanolamine 0
                                                      1-linoleoylglycerone 3-phosphate 0
                                                      1-monolinolein + 0
                                                      1-myristoyl-2-linoleoyl-sn-glycerol 0
                                                      1-octadecanoyl-2-[(9Z,12Z)-octadecadienoyl]-sn-glycero-3-phosphocholine 0
                                                      1-oleoyl-2,3-di-linoleoyl-sn-glycerol 0
                                                      1-oleoyl-2-linoleoyl-sn-glycero-3-phosphate 0
                                                      1-oleoyl-2-linoleoyl-sn-glycero-3-phospho-L-serine 0
                                                      1-oleoyl-2-linoleoyl-sn-glycerol 0
                                                      1-oleoyl-2-linoleyl-sn-glycero-3-phosphoethanolamine 0
                                                      1-oleoyl-3-linoleoylglycerol 0
                                                      1-oleyl-2-linoleyl-PAP 0
                                                      1-palmitoleoyl-2-linoleoyl-sn-glycero-3-phosphocholine 0
                                                      1-palmitoleoyl-2-linoleoyl-sn-glycerol 0
                                                      1-palmitoyl-2-linoleoyl-sn-glycerol 0
                                                      1-palmitoyl-3-linoleoylglycerol 0
                                                      1-palmityl-2-acetyl-3-linoleoyl-sn-glycerol 0
                                                      1-pentadecanoyl-2-linoleoyl-sn-glycero-3-phosphocholine 0
                                                      1-stearoyl-2-linoleoyl-sn-glycero-3-phospho-1D-myo-inositol 0
                                                      1-stearoyl-2-linoleoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate 0
                                                      1-stearoyl-2-linoleoyl-sn-glycero-3-phospho-L-serine 0
                                                      1-stearoyl-2-linoleoyl-sn-glycero-3-phosphoethanolamine 0
                                                      1-stearoyl-2-linoleoyl-sn-glycerol 2
                                                      1-tetradecanoyl-2-[(9Z,12Z)-octadecadienoyl]-sn-glycero-3-phosphocholine 0
                                                      12,13-epoxy-18-hydroxy-(9Z)-octadecenoic acid 0
                                                      13-hydroperoxylinoleic acid 0
                                                      18-hydroxylinoleic acid 0
                                                      2,3-dilinoleoyl-sn-glycerol 0
                                                      2-hydroxylinoleic acid 0
                                                      2-linoleoyl-sn-glycero-3-phosphocholine 0
                                                      2-linoleoyl-sn-glycero-3-phosphoethanolamine 0
                                                      2-linoleoyl-sn-glycero-3-phosphoethanolamine zwitterion 0
                                                      2-linoleoylglycerol 0
                                                      5(S),8(R)-DiHODE 0
                                                      7(S),8(S)-DiHODE 0
                                                      7-demethoxyegonol-9(Z),12(Z)linoleate 0
                                                      8(R)-HPODE 0
                                                      9,10-epoxy-18-hydroxy-(12Z)-octadecenoic acid 0
                                                      CDP-1,2-dilinoleoyl-sn-glycerol 0
                                                      CDP-1-stearoyl-2-linoleoyl-sn-glycerol 0
                                                      HPODE + 10
                                                      N,1-dipalmitoyl-2-linoleoyl-sn-glycero-3-phosphoethanolamine 0
                                                      N-butyryl-1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphoethanolamine 0
                                                      N-caproyl-1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphoethanolamine 0
                                                      N-capryl-1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphoethanolamine 0
                                                      N-capryloyl-1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphoethanolamine 0
                                                      O-linoleyl-L-carnitine 0
                                                      all-trans-retinyl linoleate 0
                                                      cholesteryl linoleate 2
                                                      dilinoleoylglycerol + 0
                                                      egonol-9(Z),12(Z)linoleate + 0
                                                      ethyl linoleate 0
                                                      laetisaric acid 0
                                                      linoleamide 1
                                                      linoleic acid hydroperoxide + 4
                                                      linoleoyl bioconjugate + 0
                                                      linoleoyl ethanolamide 0
                                                      linoleoyl group 0
                                                      linoleoyl-containing glycerolipid 0
                                                      linoleoyl-sn-glycero-3-phosphocholine + 0
                                                      linoleylanilide 0
                                                      methyl linoleate + 0
                                                      propyl linoleate 0
                                                      tetralinoleoyl cardiolipin 0
                                                      trilinoleoyl 2-monolysocardiolipin 0
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