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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:guanosine 5'-monophosphate
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Accession:CHEBI:17345 term browser browse the term
Definition:A purine ribonucleoside 5'-monophosphate having guanine as the nucleobase.
Synonyms:exact_synonym: [(2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen phosphate
 related_synonym: 5'-GMP;   5'-guanylic acid;   Formula=C10H14N5O8P;   GMP;   Guanosine 5'-phosphate;   Guanosine monophosphate;   Guanylic acid;   InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1;   InChIKey=RQFCJASXJCIDSX-UUOKFMHZSA-N;   SMILES=Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O;   pG
 alt_id: CHEBI:13341;   CHEBI:14381;   CHEBI:24449;   CHEBI:24450;   CHEBI:40119;   CHEBI:42647;   CHEBI:42831;   CHEBI:42887;   CHEBI:42979;   CHEBI:47450;   CHEBI:5228
 xref: CAS:85-32-5;   DrugBank:DB01972;   HMDB:HMDB0001397;   KEGG:C00144;   KNApSAcK:C00019635
 xref_mesh: MESH:D006157
 xref: MetaCyc:GMP;   PDBeChem:5GP;   PMID:11233304;   PMID:11670950;   PMID:22735334;   PMID:2559771;   PMID:3569407;   Reaxys:59430;   Wikipedia:Guanosine_monophosphate
 cyclic_relationship: is_conjugate_acid_of CHEBI:58115


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guanosine 5'-monophosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fut8 fucosyltransferase 8 decreases activity ISO Guanosine Monophosphate results in decreased activity of FUT8 protein CTD PMID:12770769 NCBI chr 6:100,305,957...100,537,208
Ensembl chr 6:100,337,226...100,537,224
JBrowse link
G Gmds GDP-mannose 4, 6-dehydratase affects binding ISO Guanosine Monophosphate binds to GMDS protein CTD PMID:25526675 NCBI chr17:33,408,722...33,938,086
Ensembl chr17:33,408,722...33,938,085
JBrowse link
poly(guanylic acid) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP Poly G inhibits the reaction [Particulate Matter results in increased expression of ACTA2 mRNA]; Poly G inhibits the reaction [Particulate Matter results in increased expression of ACTA2 protein]; Poly G inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 mRNA]; Poly G inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein] CTD PMID:30391304, PMID:31028789 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Atf6 activating transcription factor 6 multiple interactions EXP Poly G inhibits the reaction [Silicon Dioxide results in increased expression of ATF6 protein] CTD PMID:31028789 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
JBrowse link
G Casp12 caspase 12 multiple interactions EXP Poly G inhibits the reaction [Silicon Dioxide results in increased expression of CASP12 protein] CTD PMID:31028789 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
JBrowse link
G Cdh1 cadherin 1 multiple interactions EXP Poly G inhibits the reaction [Particulate Matter results in decreased expression of CDH1 mRNA]; Poly G inhibits the reaction [Particulate Matter results in decreased expression of CDH1 protein]; Poly G inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 mRNA]; Poly G inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 protein] CTD PMID:30391304, PMID:31028789 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP Poly G inhibits the reaction [Particulate Matter results in increased expression of COL1A1 mRNA]; Poly G inhibits the reaction [Silicon Dioxide results in increased expression of COL1A1 mRNA] CTD PMID:30391304, PMID:31028789 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions EXP Poly G inhibits the reaction [Particulate Matter results in increased expression of COL3A1 mRNA]; Poly G inhibits the reaction [Silicon Dioxide results in increased expression of COL3A1 mRNA] CTD PMID:30391304, PMID:31028789 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions EXP Poly G inhibits the reaction [Silicon Dioxide results in increased expression of DDIT3 protein] CTD PMID:31028789 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions EXP Poly G inhibits the reaction [Silicon Dioxide results in increased expression of ERN1 protein] CTD PMID:31028789 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Poly G inhibits the reaction [Silicon Dioxide results in increased expression of HSPA5 protein] CTD PMID:31028789 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Marco macrophage receptor with collagenous structure multiple interactions ISO
EXP
Poly G inhibits the reaction [MARCO protein binds to and results in increased uptake of Polystyrenes]
Poly G inhibits the reaction [Particulate Matter results in increased expression of MARCO protein]; Poly G inhibits the reaction [Silicon Dioxide results in increased expression of MARCO protein]
CTD PMID:17361018, PMID:30391304, PMID:31028789 NCBI chr16:85,115,199...85,147,683
Ensembl chr16:85,115,201...85,135,859
JBrowse link
G Vim vimentin multiple interactions EXP Poly G inhibits the reaction [Particulate Matter results in increased expression of VIM mRNA]; Poly G inhibits the reaction [Particulate Matter results in increased expression of VIM protein]; Poly G inhibits the reaction [Silicon Dioxide results in increased expression of VIM mRNA]; Poly G inhibits the reaction [Silicon Dioxide results in increased expression of VIM protein] CTD PMID:30391304, PMID:31028789 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        biochemical role 19281
          metabolite 19262
            guanosine 5'-monophosphate 13
              (R)-lipoyl-GMP 0
              2'-O-methylguanosine 5'-monophosphate + 0
              4-demethylwyosine 5'-monophosphate + 0
              7-methylguanosine 5'-phosphate(1+) 0
              8-oxo-GMP 0
              GMP 3'-end residue + 11
              GMP 5'-end residue + 11
              N(1)-methylguanosine 5'-monophosphate + 0
              N(2),N(2),N(7)-trimethylguanosine 5'-phosphate 0
              N(2),N(2)-dimethylguanosine 5'-monophosphate + 0
              N(2)-methylguanosine 5'-monophosphate + 0
              N(6)-(5'-guanylyl)-L-lysine 0
              N(7)-methylguanosine 5'-phosphate + 0
              N(epsilon)-(5'-guanylyl)-N(alpha)-acetyl-L-lysine methyl ester(1-) 0
              N(epsilon)-GMP-N(alpha)-acetyl-L-lysine methyl ester 0
              beta-hydroxywybutosine 5'-monophosphate + 0
              coenzyme F390-G 0
              ddhGMP 0
              guanosine 5'-monophosphate residue + 11
              wybutosine 5'-monophosphate + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      chalcogen 19360
                        oxygen atom 19321
                          oxygen molecular entity 19321
                            hydroxides 19066
                              oxoacid 18192
                                pnictogen oxoacid 10144
                                  phosphorus oxoacid 9032
                                    phosphoric acids 7794
                                      phosphoric acid 7794
                                        phosphoric acid derivative 7473
                                          phosphate 7473
                                            organic phosphate 7472
                                              carbohydrate phosphate 1528
                                                phospho sugar 1454
                                                  aldose phosphate 1452
                                                    aldopentose phosphate 1446
                                                      ribose phosphate 1440
                                                        ribonucleotide 1401
                                                          purine ribonucleotide 1374
                                                            guanyl ribonucleotide 129
                                                              guanosine phosphate 60
                                                                guanosine 5'-phosphate 60
                                                                  guanosine 5'-monophosphate 13
                                                                    (R)-lipoyl-GMP 0
                                                                    2'-O-methylguanosine 5'-monophosphate + 0
                                                                    4-demethylwyosine 5'-monophosphate + 0
                                                                    7-methylguanosine 5'-phosphate(1+) 0
                                                                    8-oxo-GMP 0
                                                                    GMP 3'-end residue + 11
                                                                    GMP 5'-end residue + 11
                                                                    N(1)-methylguanosine 5'-monophosphate + 0
                                                                    N(2),N(2),N(7)-trimethylguanosine 5'-phosphate 0
                                                                    N(2),N(2)-dimethylguanosine 5'-monophosphate + 0
                                                                    N(2)-methylguanosine 5'-monophosphate + 0
                                                                    N(6)-(5'-guanylyl)-L-lysine 0
                                                                    N(7)-methylguanosine 5'-phosphate + 0
                                                                    N(epsilon)-(5'-guanylyl)-N(alpha)-acetyl-L-lysine methyl ester(1-) 0
                                                                    N(epsilon)-GMP-N(alpha)-acetyl-L-lysine methyl ester 0
                                                                    beta-hydroxywybutosine 5'-monophosphate + 0
                                                                    coenzyme F390-G 0
                                                                    ddhGMP 0
                                                                    guanosine 5'-monophosphate residue + 11
                                                                    wybutosine 5'-monophosphate + 0
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