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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:phytol
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Accession:CHEBI:17327 term browser browse the term
Definition:A diterpenoid that is hexadec-2-en-1-ol substituted by methyl groups at positions 3, 7, 11 and 15.
Synonyms:exact_synonym: (2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol
 related_synonym: (2E,7R,11R)-3,7,11,15-tetramethyl-2-hexadecen-1-ol;   Formula=C20H40O;   InChI=1S/C20H40O/c1-17(2)9-6-10-18(3)11-7-12-19(4)13-8-14-20(5)15-16-21/h15,17-19,21H,6-14,16H2,1-5H3/b20-15+/t18-,19-/m1/s1;   InChIKey=BOTWFXYSPFMFNR-PYDDKJGSSA-N;   SMILES=CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC\\C(C)=C\\CO;   trans-Phytol
 alt_id: CHEBI:14836;   CHEBI:26121;   CHEBI:8193
 xref: CAS:150-86-7;   CAS:7541-49-3;   HMDB:HMDB0002019;   KEGG:C01389;   KNApSAcK:C00003467;   LIPID_MAPS_instance:LMPR0104010002
 xref_mesh: MESH:D010836
 xref: MetaCyc:PHYTOL;   PMID:17015885;   PMID:24333358;   PMID:24392173;   PMID:24422895;   Reaxys:7855349


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phytol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 increases expression
multiple interactions
ISO Phytol results in increased expression of ALDH3A2 protein
PPARA protein affects the reaction [Phytol results in increased expression of ALDH3A2 protein]
CTD PMID:17015885 NCBI chr10:47,525,486...47,546,535
Ensembl chr10:47,525,493...47,546,345
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Phytol inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX protein] CTD PMID:30520250 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO Phytol inhibits the reaction [Benzo(a)pyrene results in decreased expression of BCL2 protein] CTD PMID:30520250 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Phytol inhibits the reaction [Benzo(a)pyrene results in increased expression of CASP3 protein] CTD PMID:30520250 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 multiple interactions ISO [Phytol co-treated with Benzo(a)pyrene] results in decreased expression of CASP9 protein CTD PMID:30520250 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase increases expression
multiple interactions
ISO Phytol results in increased expression of CAT
Phytol inhibits the reaction [Benzo(a)pyrene results in increased expression of CAT protein]
CTD PMID:19188468, PMID:30520250 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO Phytol inhibits the reaction [Benzo(a)pyrene results in increased expression of GSR protein] CTD PMID:30520250 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK1 protein]]; Acetylcysteine affects the reaction [Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK1 protein]]; Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK1 protein] CTD PMID:29486182 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK3 protein]]; Acetylcysteine affects the reaction [Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK3 protein]]; Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK3 protein] CTD PMID:29486182 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mitf melanocyte inducing transcription factor multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]] which results in decreased ubiquitination of MITF protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]]; [Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]] which results in decreased ubiquitination of MITF protein; Acetylcysteine inhibits the reaction [Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]] which results in decreased ubiquitination of MITF protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]]; Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein] CTD PMID:29486182 NCBI chr 4:130,172,484...130,425,496
Ensembl chr 4:130,172,727...130,425,532
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha affects metabolic processing
multiple interactions
ISO PPARA protein affects the metabolism of Phytol
PPARA protein affects the reaction [Phytol results in increased expression of ALDH3A2 protein]
CTD PMID:17015885 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppargc1b PPARG coactivator 1 beta increases activity ISO Phytol results in increased activity of PPARGC1B protein CTD PMID:17015885 NCBI chr18:56,626,725...56,650,524
Ensembl chr18:56,626,712...56,728,968
JBrowse link
G Tyr tyrosinase multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytol inhibits the reaction [alpha-MSH results in increased expression of TYR protein]]; Phytol inhibits the reaction [alpha-MSH results in increased expression of TYR protein] CTD PMID:29486182 NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802
JBrowse link
G Tyrp1 tyrosinase-related protein 1 multiple interactions ISO Phytol inhibits the reaction [alpha-MSH results in increased expression of TYRP1 protein] CTD PMID:29486182 NCBI chr 5:98,387,291...98,406,083
Ensembl chr 5:98,387,291...98,406,083
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        biochemical role 19281
          metabolite 19262
            eukaryotic metabolite 18906
              plant metabolite 17359
                phytol 14
                  phytyl diphosphate 0
                  phytyl phosphate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    main group molecular entity 19670
                      s-block molecular entity 19428
                        hydrogen molecular entity 19418
                          hydrides 18685
                            organic hydride 18248
                              organic fundamental parent 18248
                                hydrocarbon 17968
                                  terpene 9593
                                    terpenoid 9577
                                      diterpenoid 8426
                                        phytol 14
                                          phytyl diphosphate 0
                                          phytyl phosphate 0
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