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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ferrostatin-1
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Accession:CHEBI:173086 term browser browse the term
Definition:An ethyl ester resulting from the formal condensation of the carboxy group of 3-amino-4-(cyclohexylamino)benzoic acid with ethanol. It is a potent inhibitor of ferroptosis, a distinct non-apoptotic form of cell death caused by lipid peroxidation. It is also a radical-trapping antioxidant and has the ability to reduce the accumulation of lipid peroxides and chain-carrying peroxyl radicals.
Synonyms:exact_synonym: ethyl 3-amino-4-(cyclohexylamino)benzoate
 related_synonym: 3-amino-4-cyclohexylaminobenzoic acid ethyl ester;   Fer-1;   Formula=C15H22N2O2;   InChI=1S/C15H22N2O2/c1-2-19-15(18)11-8-9-14(13(16)10-11)17-12-6-4-3-5-7-12/h8-10,12,17H,2-7,16H2,1H3;   InChIKey=UJHBVMHOBZBWMX-UHFFFAOYSA-N;   SMILES=CCOC(=O)C1=CC(N)=C(NC2CCCCC2)C=C1;   ferrrostatin 1
 xref: CAS:347174-05-4
 xref_mesh: MESH:C573944
 xref: PMID:22632970;   PMID:26385697;   PMID:26410073;   PMID:26696014;   PMID:28250973;   PMID:28386601;   PMID:28783875;   PMID:30354101;   PMID:31531196;   PMID:31571665;   PMID:31574461;   PMID:31864943;   PMID:32161620;   PMID:32984038;   PMID:33109343;   PMID:33126055;   PMID:33278745;   PMID:33464146;   PMID:33631670;   PMID:33669598;   PMID:33991524



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ferrostatin-1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acsl4 acyl-CoA synthetase long-chain family member 4 multiple interactions ISO ferrostatin-1 inhibits the reaction [Acrolein results in increased expression of ACSL4 protein] CTD PMID:34813903 NCBI chr  X:105,942,794...106,006,573
Ensembl chr  X:105,942,799...106,006,427
JBrowse link
G Ascl4 achaete-scute family bHLH transcription factor 4 multiple interactions EXP ferrostatin-1 inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of ASCL4 protein] CTD PMID:33737050 NCBI chr 7:17,940,899...17,943,629
Ensembl chr 7:17,941,709...17,942,146
JBrowse link
G Atg5 autophagy related 5 multiple interactions EXP ferrostatin-1 inhibits the reaction [Arsenic Trioxide results in decreased expression of ATG5 protein] CTD PMID:35195477 NCBI chr20:47,798,222...47,889,216
Ensembl chr20:47,798,290...47,889,209
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions ISO ferrostatin-1 inhibits the reaction [Ethanol results in decreased expression of ATP2A2 mRNA]; ferrostatin-1 inhibits the reaction [Ethanol results in decreased expression of ATP2A2 protein] CTD PMID:34864093 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP ferrostatin-1 inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein] CTD PMID:35195477 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP ferrostatin-1 inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein] CTD PMID:35195477 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Becn1 beclin 1 multiple interactions EXP ferrostatin-1 inhibits the reaction [Arsenic Trioxide results in decreased expression of BECN1 protein] CTD PMID:35195477 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C multiple interactions ISO ferrostatin-1 inhibits the reaction [Ethanol results in decreased expression of CACNA1C mRNA] CTD PMID:34864093 NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
JBrowse link
G Casp3 caspase 3 multiple interactions EXP ferrostatin-1 inhibits the reaction [Arsenic Trioxide results in increased cleavage of CASP3 protein] CTD PMID:35195477 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions EXP ferrostatin-1 inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CDKN1A protein] CTD PMID:33737050 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions EXP ferrostatin-1 inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CDKN2A protein] CTD PMID:33737050 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO [ferrostatin-1 co-treated with Benzene] results in increased expression of CYBB protein; ferrostatin-1 inhibits the reaction [Benzene results in increased expression of CYBB mRNA] CTD PMID:35661779 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO ferrostatin-1 affects the reaction [CYP2E1 protein affects the susceptibility to Ethanol]; FXN protein affects the reaction [ferrostatin-1 affects the reaction [CYP2E1 protein affects the susceptibility to Ethanol]] CTD PMID:33017621 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions EXP ferrostatin-1 inhibits the reaction [Arsenic Trioxide results in increased expression of DDIT3 protein] CTD PMID:35195477 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions EXP
ISO
ferrostatin-1 inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of FTH1 protein]
ferrostatin-1 inhibits the reaction [Benzene results in increased expression of FTH1 mRNA]; ferrostatin-1 inhibits the reaction [Benzene results in increased expression of FTH1 protein]; ferrostatin-1 inhibits the reaction [Ethanol results in decreased expression of FTH1 protein]
CTD PMID:33737050 PMID:34864093 PMID:35661779 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
JBrowse link
G Ftl1 ferritin light chain 1 multiple interactions ISO ferrostatin-1 inhibits the reaction [Benzene results in increased expression of FTL1 protein]; ferrostatin-1 inhibits the reaction [Ethanol results in decreased expression of FTL1 protein] CTD PMID:34864093 PMID:35661779 NCBI chr 1:95,936,390...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725
JBrowse link
G Fxn frataxin multiple interactions ISO FXN protein affects the reaction [ferrostatin-1 affects the reaction [CYP2E1 protein affects the susceptibility to Ethanol]] CTD PMID:33017621 NCBI chr 1:221,874,007...221,897,841
Ensembl chr 1:221,872,420...221,897,540
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO ferrostatin-1 inhibits the reaction [Benzene results in decreased expression of GCLC mRNA] CTD PMID:35661779 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Glb1 galactosidase, beta 1 multiple interactions EXP ferrostatin-1 inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of GLB1 protein] CTD PMID:33737050 NCBI chr 8:114,085,508...114,158,127
Ensembl chr 8:114,085,508...114,158,127
JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions ISO
EXP
ferrostatin-1 inhibits the reaction [Acrolein results in decreased expression of GPX4 protein]; ferrostatin-1 inhibits the reaction [Benzene results in decreased expression of GPX4 mRNA]; ferrostatin-1 inhibits the reaction [Benzene results in decreased expression of GPX4 protein]; ferrostatin-1 inhibits the reaction [Busulfan results in decreased expression of and results in decreased activity of GPX4 protein]; ferrostatin-1 inhibits the reaction [Cisplatin results in decreased expression of GPX4 protein]; ferrostatin-1 inhibits the reaction [Ethanol results in decreased expression of GPX4 mRNA]; ferrostatin-1 inhibits the reaction [Ethanol results in decreased expression of GPX4 protein]
ferrostatin-1 inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of GPX4 protein]; ferrostatin-1 inhibits the reaction [Arsenic Trioxide results in decreased expression of GPX4 mRNA]; ferrostatin-1 inhibits the reaction [Arsenic Trioxide results in decreased expression of GPX4 protein]; ferrostatin-1 inhibits the reaction [Fluorouracil results in decreased expression of GPX4 protein]
ferrostatin-1 inhibits the reaction [sodium arsenite results in decreased expression of GPX4 protein]
CTD PMID:32416107 PMID:32593899 PMID:33737050 PMID:34302894 PMID:34813903 More... NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions ISO ferrostatin-1 inhibits the reaction [Cisplatin results in increased expression of HAVCR1 mRNA] CTD PMID:34785303 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO ferrostatin-1 inhibits the reaction [sodium arsenite results in increased expression of IL1B protein] CTD PMID:32593899 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO ferrostatin-1 inhibits the reaction [sodium arsenite results in increased expression of IL6 protein] CTD PMID:32593899 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Kcna5 potassium voltage-gated channel subfamily A member 5 multiple interactions ISO ferrostatin-1 inhibits the reaction [Ethanol results in decreased expression of KCNA5 mRNA]; ferrostatin-1 inhibits the reaction [Ethanol results in decreased expression of KCNA5 protein] CTD PMID:34864093 NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697
JBrowse link
G Kcnb1 potassium voltage-gated channel subfamily B member 1 multiple interactions ISO ferrostatin-1 inhibits the reaction [Ethanol results in decreased expression of KCNB1 mRNA]; ferrostatin-1 inhibits the reaction [Ethanol results in decreased expression of KCNB1 protein] CTD PMID:34864093 NCBI chr 3:155,820,255...155,913,383
Ensembl chr 3:155,822,963...155,916,194
JBrowse link
G Kcnd3 potassium voltage-gated channel subfamily D member 3 multiple interactions ISO ferrostatin-1 inhibits the reaction [Ethanol results in decreased expression of KCND3 mRNA] CTD PMID:34864093 NCBI chr 2:192,937,950...193,155,345
Ensembl chr 2:192,937,950...193,155,345
JBrowse link
G Lcn2 lipocalin 2 multiple interactions ISO ferrostatin-1 inhibits the reaction [Cisplatin results in increased expression of LCN2 mRNA] CTD PMID:34785303 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions EXP [ferrostatin-1 co-treated with Arsenic Trioxide] results in increased lipidation of MAP1LC3B protein CTD PMID:35195477 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO ferrostatin-1 inhibits the reaction [Busulfan results in decreased expression of NFE2L2 protein] CTD PMID:32416107 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Pln phospholamban multiple interactions ISO ferrostatin-1 inhibits the reaction [Ethanol results in decreased phosphorylation of PLN protein] CTD PMID:34864093 NCBI chr20:32,629,537...32,639,559 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO ferrostatin-1 inhibits the reaction [Acrolein results in increased expression of PTGS2 protein]; ferrostatin-1 inhibits the reaction [Busulfan results in increased expression of PTGS2 mRNA]; ferrostatin-1 inhibits the reaction [Cisplatin results in increased expression of PTGS2 mRNA]; ferrostatin-1 inhibits the reaction [Cisplatin results in increased expression of PTGS2 protein]; ferrostatin-1 inhibits the reaction [Ethanol results in increased expression of PTGS2 mRNA]; ferrostatin-1 inhibits the reaction [Ethanol results in increased expression of PTGS2 protein]
ferrostatin-1 inhibits the reaction [sodium arsenite results in increased expression of PTGS2 protein]
CTD PMID:32416107 PMID:32593899 PMID:34785303 PMID:34813903 PMID:34864093 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Sesn2 sestrin 2 multiple interactions ISO ferrostatin-1 inhibits the reaction [erastin results in increased expression of SESN2 protein] CTD PMID:31323261 NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260
JBrowse link
G Slc40a1 solute carrier family 40 member 1 multiple interactions ISO ferrostatin-1 inhibits the reaction [Busulfan results in decreased expression of SLC40A1 protein] CTD PMID:32416107 NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481
JBrowse link
G Slc7a11 solute carrier family 7 member 11 multiple interactions EXP
ISO
ferrostatin-1 inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SLC7A11 protein]
ferrostatin-1 inhibits the reaction [Benzene results in decreased expression of SLC7A11 mRNA]; ferrostatin-1 inhibits the reaction [Benzene results in decreased expression of SLC7A11 protein]; ferrostatin-1 inhibits the reaction [Cisplatin results in decreased expression of SLC7A11 protein]
CTD PMID:33737050 PMID:34302894 PMID:35661779 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP ferrostatin-1 inhibits the reaction [Arsenic Trioxide results in increased expression of SQSTM1 protein] CTD PMID:35195477 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Tfrc transferrin receptor multiple interactions EXP
ISO
ferrostatin-1 inhibits the reaction [Fluorouracil results in increased expression of TFRC protein]
ferrostatin-1 inhibits the reaction [Benzene results in increased expression of TFRC protein]
CTD PMID:35101590 PMID:35661779 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO ferrostatin-1 inhibits the reaction [sodium arsenite results in increased expression of TNF protein] CTD PMID:32593899 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP ferrostatin-1 inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TP53 protein]; ferrostatin-1 inhibits the reaction [Fluorouracil results in increased expression of TRP53 protein] CTD PMID:33737050 PMID:35101590 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

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  CHEBI ontology 19659
    role 19634
      chemical role 19279
        antioxidant 15643
          ferrostatin-1 38
            SRS11-92 0
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Term Annotations click to browse term
  CHEBI ontology 19659
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19700
                atom 19658
                  main group element atom 19607
                    main group molecular entity 19649
                      s-block molecular entity 19457
                        hydrogen molecular entity 19450
                          hydrides 18928
                            inorganic hydride 17765
                              pnictogen hydride 17748
                                nitrogen hydride 17633
                                  azane 17403
                                    ammonia 17402
                                      organic amino compound 17402
                                        aromatic amine 14884
                                          anilines 13948
                                            substituted aniline 13624
                                              ferrostatin-1 38
                                                SRS11-92 0
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