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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ferrostatin-1
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Accession:CHEBI:173086 term browser browse the term
Definition:An ethyl ester resulting from the formal condensation of the carboxy group of 3-amino-4-(cyclohexylamino)benzoic acid with ethanol. It is a potent inhibitor of ferroptosis, a distinct non-apoptotic form of cell death caused by lipid peroxidation. It is also a radical-trapping antioxidant and has the ability to reduce the accumulation of lipid peroxides and chain-carrying peroxyl radicals.
Synonyms:exact_synonym: ethyl 3-amino-4-(cyclohexylamino)benzoate
 related_synonym: 3-amino-4-cyclohexylaminobenzoic acid ethyl ester;   Fer-1;   Formula=C15H22N2O2;   InChI=1S/C15H22N2O2/c1-2-19-15(18)11-8-9-14(13(16)10-11)17-12-6-4-3-5-7-12/h8-10,12,17H,2-7,16H2,1H3;   InChIKey=UJHBVMHOBZBWMX-UHFFFAOYSA-N;   SMILES=CCOC(=O)C1=CC(N)=C(NC2CCCCC2)C=C1;   ferrrostatin 1
 xref: CAS:347174-05-4
 xref_mesh: MESH:C573944
 xref: PMID:22632970;   PMID:26385697;   PMID:26410073;   PMID:26696014;   PMID:28250973;   PMID:28386601;   PMID:28783875;   PMID:30354101;   PMID:31531196;   PMID:31571665;   PMID:31574461;   PMID:31864943;   PMID:32161620;   PMID:32984038;   PMID:33109343;   PMID:33126055;   PMID:33278745;   PMID:33464146;   PMID:33631670;   PMID:33669598;   PMID:33991524


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ferrostatin-1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO ferrostatin-1 affects the reaction [CYP2E1 protein affects the susceptibility to Ethanol]; FXN protein affects the reaction [ferrostatin-1 affects the reaction [CYP2E1 protein affects the susceptibility to Ethanol]] CTD PMID:33017621 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Fxn frataxin multiple interactions ISO FXN protein affects the reaction [ferrostatin-1 affects the reaction [CYP2E1 protein affects the susceptibility to Ethanol]] CTD PMID:33017621 NCBI chr 1:221,874,007...221,897,841
Ensembl chr 1:221,872,420...221,897,540
JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions ISO ferrostatin-1 inhibits the reaction [Busulfan results in decreased expression of and results in decreased activity of GPX4 protein]
ferrostatin-1 inhibits the reaction [sodium arsenite results in decreased expression of GPX4 protein]
CTD PMID:32416107 PMID:32593899 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO ferrostatin-1 inhibits the reaction [sodium arsenite results in increased expression of IL1B protein] CTD PMID:32593899 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO ferrostatin-1 inhibits the reaction [sodium arsenite results in increased expression of IL6 protein] CTD PMID:32593899 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO ferrostatin-1 inhibits the reaction [Busulfan results in decreased expression of NFE2L2 protein] CTD PMID:32416107 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO ferrostatin-1 inhibits the reaction [Busulfan results in increased expression of PTGS2 mRNA]
ferrostatin-1 inhibits the reaction [sodium arsenite results in increased expression of PTGS2 protein]
CTD PMID:32416107 PMID:32593899 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Sesn2 sestrin 2 multiple interactions ISO ferrostatin-1 inhibits the reaction [erastin results in increased expression of SESN2 protein] CTD PMID:31323261 NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260
JBrowse link
G Slc40a1 solute carrier family 40 member 1 multiple interactions ISO ferrostatin-1 inhibits the reaction [Busulfan results in decreased expression of SLC40A1 protein] CTD PMID:32416107 NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO ferrostatin-1 inhibits the reaction [sodium arsenite results in increased expression of TNF protein] CTD PMID:32593899 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

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Path 1
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  CHEBI ontology 19812
    role 19761
      chemical role 19336
        antioxidant 14442
          ferrostatin-1 10
            SRS11-92 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    main group molecular entity 19708
                      s-block molecular entity 19493
                        hydrogen molecular entity 19488
                          hydrides 18845
                            inorganic hydride 17691
                              pnictogen hydride 17672
                                nitrogen hydride 17545
                                  azane 17279
                                    ammonia 17278
                                      organic amino compound 17278
                                        aromatic amine 13701
                                          anilines 12359
                                            substituted aniline 11852
                                              ferrostatin-1 10
                                                SRS11-92 0
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