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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:copanlisib
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Accession:CHEBI:173077 term browser browse the term
Definition:An imidazoquinazoline that is 2,3-dihydroimidazo[1,2-c]quinazoline substituted by (2-aminopyrimidine-5-carbonyl)amino, methoxy, and 3-(morpholin-4-yl)propoxy groups at positions 5, 7 and 8, respectively. It is a intravenous pan-class I PI3K inhibitor used for the treatment of relapsed follicular lymphoma in patients who have received at least 2 prior systemic therapies.
Synonyms:exact_synonym: 2-amino-N-{7-methoxy-8-[3-(morpholin-4-yl)propoxy]-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl}pyrimidine-5-carboxamide
 related_synonym: BAY 80-6946;   BAY80-6946;   Formula=C23H28N8O4;   InChI=1S/C23H28N8O4/c1-33-19-17(35-10-2-6-30-8-11-34-12-9-30)4-3-16-18(19)28-23(31-7-5-25-20(16)31)29-21(32)15-13-26-22(24)27-14-15/h3-4,13-14H,2,5-12H2,1H3,(H2,24,26,27)(H,28,29,32);   InChIKey=PZBCKZWLPGJMAO-UHFFFAOYSA-N;   SMILES=COC1=C(OCCCN2CCOCC2)C=CC2=C1N=C(NC(=O)C1=CN=C(N)N=C1)N1CCN=C21;   copanlisibum
 xref: CAS:1032568-63-0;   Chemspider:25069683;   DrugBank:DB12483;   Drug_Central:5256;   KEGG:D10867
 xref_mesh: MESH:C000589253
 xref: PDBeChem:6E2;   PMID:24170767;   PMID:24852792;   PMID:24942196;   PMID:25528022;   PMID:27310202;   PMID:27672108;   PMID:28714036;   PMID:30147333;   PMID:30174412;   PMID:30430191;   PMID:30813760;   PMID:30962952;   PMID:31934607;   PMID:32126142;   PMID:32183683;   PMID:32371592;   PMID:32483262;   PMID:32576028;   PMID:32658557;   PMID:33108585;   PMID:33110476;   PMID:33125719;   PMID:33139695;   PMID:33289918;   PMID:33352201;   PMID:33531838;   PMID:33560394;   PMID:33687623;   PMID:33771771;   PMID:33799597;   PMID:33839692;   PMID:33848462;   PMID:33879868;   PMID:33889376;   PMID:33942546;   Wikipedia:Copanlisib


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copanlisib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO copanlisib results in decreased phosphorylation of AKT1 protein CTD PMID:31445927 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Fas Fas cell surface death receptor affects response to substance ISO copanlisib affects the susceptibility to FAS protein CTD PMID:31445927 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Tnf tumor necrosis factor increases response to substance ISO copanlisib results in increased susceptibility to TNF protein CTD PMID:31445927 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19921
    role 19896
      biological role 19894
        biochemical role 19584
          apoptosis inducer 13632
            copanlisib 3
              copanlisib dihydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19867
                    p-block element atom 19867
                      carbon group element atom 19812
                        carbon atom 19807
                          organic molecular entity 19807
                            organic group 18971
                              organic divalent group 18952
                                organodiyl group 18952
                                  carbonyl group 18905
                                    carbonyl compound 18905
                                      carboxylic acid 18622
                                        carboacyl group 17704
                                          univalent carboacyl group 17704
                                            carbamoyl group 17550
                                              carboxamide 17550
                                                monocarboxylic acid amide 15653
                                                  pyrimidinecarboxamide 3
                                                    copanlisib 3
                                                      copanlisib dihydrochloride 0
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