Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:copanlisib
go back to main search page
Accession:CHEBI:173077 term browser browse the term
Definition:An imidazoquinazoline that is 2,3-dihydroimidazo[1,2-c]quinazoline substituted by (2-aminopyrimidine-5-carbonyl)amino, methoxy, and 3-(morpholin-4-yl)propoxy groups at positions 5, 7 and 8, respectively. It is a intravenous pan-class I PI3K inhibitor used for the treatment of relapsed follicular lymphoma in patients who have received at least 2 prior systemic therapies.
Synonyms:exact_synonym: 2-amino-N-{7-methoxy-8-[3-(morpholin-4-yl)propoxy]-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl}pyrimidine-5-carboxamide
 related_synonym: BAY 80-6946;   BAY80-6946;   Formula=C23H28N8O4;   InChI=1S/C23H28N8O4/c1-33-19-17(35-10-2-6-30-8-11-34-12-9-30)4-3-16-18(19)28-23(31-7-5-25-20(16)31)29-21(32)15-13-26-22(24)27-14-15/h3-4,13-14H,2,5-12H2,1H3,(H2,24,26,27)(H,28,29,32);   InChIKey=PZBCKZWLPGJMAO-UHFFFAOYSA-N;   SMILES=COC1=C(OCCCN2CCOCC2)C=CC2=C1N=C(NC(=O)C1=CN=C(N)N=C1)N1CCN=C21;   copanlisibum
 xref: CAS:1032568-63-0;   Chemspider:25069683;   DrugBank:DB12483;   Drug_Central:5256;   KEGG:D10867
 xref_mesh: MESH:C000589253
 xref: PDBeChem:6E2;   PMID:24170767;   PMID:24852792;   PMID:24942196;   PMID:25528022;   PMID:27310202;   PMID:27672108;   PMID:28714036;   PMID:30147333;   PMID:30174412;   PMID:30430191;   PMID:30813760;   PMID:30962952;   PMID:31934607;   PMID:32126142;   PMID:32183683;   PMID:32371592;   PMID:32483262;   PMID:32576028;   PMID:32658557;   PMID:33108585;   PMID:33110476;   PMID:33125719;   PMID:33139695;   PMID:33289918;   PMID:33352201;   PMID:33531838;   PMID:33560394;   PMID:33687623;   PMID:33771771;   PMID:33799597;   PMID:33839692;   PMID:33848462;   PMID:33879868;   PMID:33889376;   PMID:33942546;   Wikipedia:Copanlisib



show annotations for term's descendants           Sort by:
 
copanlisib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO copanlisib results in decreased phosphorylation of AKT1 protein CTD PMID:31445927 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Fas Fas cell surface death receptor affects response to substance ISO copanlisib affects the susceptibility to FAS protein CTD PMID:31445927 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Tnf tumor necrosis factor increases response to substance ISO copanlisib results in increased susceptibility to TNF protein CTD PMID:31445927 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      biological role 20011
        biochemical role 19671
          apoptosis inducer 13408
            copanlisib 3
              copanlisib dihydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic group 18988
                              organic divalent group 18950
                                organodiyl group 18974
                                  carbonyl group 18903
                                    carbonyl compound 18925
                                      carboxylic acid 18597
                                        carboacyl group 17730
                                          univalent carboacyl group 17710
                                            carbamoyl group 17550
                                              carboxamide 17570
                                                monocarboxylic acid amide 15534
                                                  pyrimidinecarboxamide 3
                                                    copanlisib 3
                                                      copanlisib dihydrochloride 0
paths to the root