The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
A morphinane alkaloid that is a highly potent opiate analgesic psychoactive drug. Morphine acts directly on the central nervous system (CNS) to relieve pain but has a high potential for addiction, with tolerance and both physical and psychological dependence developing rapidly. Morphine is the most abundant opiate found in Papaver somniferum (the opium poppy).
Morphine results in decreased expression of ACAT1 protein Morphine deficiency affects the reaction [Morphine results in decreased expression of ACAT1 protein]
[ACHE protein results in increased degradation of 6-O-monoacetylmorphine] which results in increased chemical synthesis of Morphine ACHE protein results in increased chemical synthesis of Morphine
ADCY8 protein affects the susceptibility to Morphine [ADCY8 protein co-treated with ADCY1 protein] affects the susceptibility to Morphine Morphine affects the expression of ADCY8 mRNA
ADORA1 protein affects the susceptibility to Morphine [lead acetate co-treated with Morphine] results in increased expression of ADORA1 mRNA; [lead acetate co-treated with Morphine] results in increased expression of ADORA1 protein Morphine results in increased expression of ADORA1 mRNA; Morphine results in increased expression of ADORA1 protein
ARRB2 protein inhibits the reaction [Morphine results in decreased expression of AKT1 protein modified form] Naloxone inhibits the reaction [Morphine results in increased expression of AKT1 protein modified form]
Morphine results in increased expression of APOE protein Morphine deficiency affects the reaction [Morphine results in increased expression of APOE protein]
ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein]; Morphine promotes the reaction [ARL6IP5 protein binds to OPRD1 protein] Morphine results in increased expression of ARL6IP5 protein ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]]; Morphine promotes the reaction [ARL6IP5 protein binds to OPRD1 protein]
ARRB2 gene SNP affects the susceptibility to Morphine [Morphine binds to and results in increased activity of OPRM1 protein] which results in increased activity of ARRB2 protein ARRB2 protein affects the susceptibility to Morphine [gp120 protein, Human immunodeficiency virus 1 co-treated with Morphine] results in decreased expression of ARRB2 mRNA; [OPRM1 protein co-treated with Morphine] results in increased activity of ARRB2 protein; ARRB2 protein inhibits the reaction [Morphine results in decreased expression of AKT1 protein modified form]; ARRB2 protein inhibits the reaction [Morphine results in decreased expression of CASP8 protein alternative form]
Morphine deficiency affects the reaction [Morphine deficiency affects the reaction [Morphine results in increased expression of ART3 protein]]; Morphine deficiency affects the reaction [Morphine results in increased expression of ART3 protein]
[[Morphine results in increased expression of BAX protein] co-treated with [Morphine results in decreased expression of BCL2 protein]] results in increased activity of CASP3 protein; [Morphine results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of BAX protein; Morphine inhibits the reaction [Dactinomycin results in increased expression of BAX protein]; Morphine inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in increased expression of BAX protein]]; PDGFB protein inhibits the reaction [Morphine results in increased expression of BAX protein] Morphine results in increased expression of BAX mRNA; Morphine results in increased expression of BAX protein Morphine results in decreased expression of BAX mRNA Lithium inhibits the reaction [Morphine results in increased expression of BAX mRNA] TGFB1 protein affects the reaction [Morphine results in increased expression of BAX protein]
BCHE protein results in increased chemical synthesis of Morphine [BCHE protein results in increased degradation of 6-O-monoacetylmorphine] which results in increased chemical synthesis of Morphine
[[Morphine results in increased expression of BAX protein] co-treated with [Morphine results in decreased expression of BCL2 protein]] results in increased activity of CASP3 protein; Morphine inhibits the reaction [BECN1 protein binds to BCL2 protein]; Morphine inhibits the reaction [Dactinomycin results in decreased expression of BCL2 protein]; Morphine inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in decreased expression of BCL2 protein]]; PDGFB protein inhibits the reaction [Morphine results in decreased expression of BCL2 protein] Morphine results in decreased expression of BCL2 mRNA; Morphine results in decreased expression of BCL2 protein Lithium inhibits the reaction [Morphine results in decreased expression of BCL2 mRNA]
Morphine results in increased expression of BDNF mRNA; Morphine results in increased expression of BDNF protein Morphine results in decreased expression of BDNF mRNA; Morphine results in decreased expression of BDNF mRNA alternative form Morphine inhibits the reaction [CREB1 protein modified form binds to BDNF promoter]; Morphine inhibits the reaction [NR4A2 protein binds to BDNF promoter]; Morphine inhibits the reaction [RING1 protein alternative form binds to BDNF promoter]; Morphine promotes the reaction [CREB1 protein binds to BDNF promoter]; Morphine promotes the reaction [EZH2 protein binds to BDNF promoter]; Morphine promotes the reaction [ING2 protein binds to BDNF promoter]; Morphine promotes the reaction [KMT2A protein binds to BDNF promoter]; Morphine promotes the reaction [SIN3A protein binds to BDNF promoter]; Morphine promotes the reaction [SUZ12 protein binds to BDNF promoter] AM 251 inhibits the reaction [Morphine results in increased expression of BDNF protein]; BDNF protein inhibits the reaction [NR4A2 protein affects the susceptibility to Morphine]; Curcumin inhibits the reaction [Morphine results in increased expression of BDNF mRNA]
Morphine results in increased expression of CALCA mRNA; Morphine results in increased expression of CALCA protein PENK protein alternative form inhibits the reaction [Morphine results in increased expression of CALCA protein] GRIK1 protein affects the reaction [Morphine results in increased expression of CALCA protein]
[[Morphine results in increased expression of BAX protein] co-treated with [Morphine results in decreased expression of BCL2 protein]] results in increased activity of CASP3 protein; Morphine inhibits the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP3 protein]; Morphine results in increased activity of and results in increased cleavage of CASP3 protein; PDGFB protein inhibits the reaction [Morphine results in increased activity of CASP3 protein] Morphine results in increased expression of CASP3 protein Minocycline inhibits the reaction [Morphine results in increased activity of CASP3 protein] Naloxone inhibits the reaction [Morphine results in increased activity of CASP3 protein]; Naloxone inhibits the reaction [Morphine results in increased expression of CASP3 protein alternative form]; SB 203580 inhibits the reaction [Morphine results in increased activity of CASP3 protein] Morphine results in increased expression of CASP3 protein; Morphine results in increased expression of CASP3 protein alternative form
ARRB2 protein inhibits the reaction [Morphine results in decreased expression of CASP8 protein alternative form] Morphine results in increased activity of CASP8 protein
beta-funaltrexamine inhibits the reaction [Morphine results in decreased expression of CCL5 protein]; Naloxone inhibits the reaction [Morphine results in decreased expression of CCL5 protein]
[Morphine results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of CDKN1A protein
CES2 protein results in increased chemical synthesis of Morphine Cocaine inhibits the reaction [CES2 protein results in increased chemical synthesis of Morphine]
[Morphine results in increased expression of CNR1 mRNA] which results in increased susceptibility to Dronabinol; Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA] Morphine deficiency results in decreased expression of CNR1 mRNA CTAP octapeptide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]]; Cycloheximide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]]; Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]
Morphine results in decreased expression of CREB1 mRNA AM 251 inhibits the reaction [Morphine results in increased phosphorylation of CREB1 protein]; suvorexant inhibits the reaction [Morphine results in increased expression of CREB1 protein] Morphine inhibits the reaction [CREB1 protein modified form binds to BDNF promoter]; Morphine inhibits the reaction [CREB1 protein modified form binds to NR4A2 promoter]; Morphine promotes the reaction [CREB1 protein binds to BDNF promoter]; Morphine promotes the reaction [CREB1 protein modified form binds to GRIA1 promoter]; Morphine promotes the reaction [CREB1 protein modified form binds to TH promoter] Morphine results in decreased phosphorylation of CREB1 protein
[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency affects the abundance of Norepinephrine]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of MAPK1 protein]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of MAPK3 protein]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of TH protein]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased secretion of POMC protein modified form]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] which results in decreased susceptibility to Morphine deficiency CRHR1 gene mutant form inhibits the reaction [[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein]
Morphine results in increased secretion of CYCS protein Morphine results in decreased secretion of CYCS protein Morphine inhibits the reaction [Doxorubicin affects the localization of CYCS protein]
CYP2D6 protein affects the chemical synthesis of Morphine Morphine results in increased activity of CYP2D6 protein [CYP2D6 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of Morphine
Morphine deficiency affects the reaction [Morphine deficiency affects the reaction [Morphine results in increased expression of DDAH2 protein]]; Morphine deficiency affects the reaction [Morphine results in increased expression of DDAH2 protein]
Morphine results in decreased expression of DLG4 mRNA; Morphine results in decreased expression of DLG4 protein Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]; resveratrol inhibits the reaction [Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]] Morphine results in increased expression of DLG4 mRNA
Morphine results in decreased expression of DRD2 mRNA Morphine deficiency results in decreased expression of DRD2 mRNA [lead acetate co-treated with Morphine] results in increased expression of DRD2 mRNA; [lead acetate co-treated with Morphine] results in increased expression of DRD2 protein DRD2 protein affects the susceptibility to Morphine Morphine results in increased expression of DRD2 mRNA
2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Morphine results in increased expression of EGR4 mRNA]; [Morphine results in increased activity of ELK1 protein] which results in increased expression of EGR4 mRNA EGR4 protein affects the susceptibility to Morphine
ELK1 protein affects the susceptibility to Morphine Morphine results in increased activity of ELK1 protein [Morphine results in increased activity of ELK1 protein] which results in increased expression of EGR4 mRNA
Morphine results in increased expression of F2 protein Morphine deficiency affects the reaction [Morphine results in increased expression of F2 protein]
[FAS protein binds to FASL protein] affects the reaction [Morphine results in increased expression of IL4 protein] [Morphine results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of FAS protein Morphine results in increased expression of FAS mRNA
[FAS protein binds to FASL protein] affects the reaction [Morphine results in increased expression of IL4 protein] Morphine results in increased expression of FASL mRNA
Morphine results in increased expression of FBLIM1 protein Morphine deficiency affects the reaction [Morphine results in increased expression of FBLIM1 protein]
Morphine results in decreased secretion of FGF2 protein Naloxone inhibits the reaction [Morphine results in decreased secretion of FGF2 protein]; OPRM1 protein affects the reaction [Morphine results in decreased secretion of FGF2 protein]
Morphine deficiency inhibits the reaction [Morphine deficiency inhibits the reaction [Morphine results in decreased expression of FHL2 protein]]; Morphine deficiency inhibits the reaction [Morphine results in decreased expression of FHL2 protein]
[Morphine co-treated with Dehydroepiandrosterone Sulfate] results in decreased expression of FOS protein; [Morphine co-treated with Dizocilpine Maleate] inhibits the reaction [Naloxone results in increased expression of FOS protein]; Plant Extracts inhibits the reaction [Morphine results in increased expression of FOS protein] Morphine deficiency affects the expression of FOS protein Morphine results in increased expression of FOS mRNA; Morphine results in increased expression of FOS protein Morphine affects the expression of FOS mRNA 1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea inhibits the reaction [[Morphine co-treated with Naloxone] results in increased expression of FOS protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Morphine results in increased expression of FOS protein]; [Morphine co-treated with Cocaine] affects the expression of FOS; [Morphine co-treated with N-Methyl-3,4-methylenedioxyamphetamine] affects the expression of FOS; [Morphine co-treated with Naloxone] results in increased expression of FOS protein; [Naloxone co-treated with Morphine] results in increased expression of FOS protein; [SCH772984 co-treated with bilobalide] inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased expression of FOS protein]]; bilobalide inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased expression of FOS protein]]; Genistein inhibits the reaction [Morphine results in increased expression of FOS protein]; Morphine affects the reaction [Formaldehyde results in increased expression of FOS protein]; N-(5-(3-dimethylaminobenzamido)-2-methylphenyl)-4-hydroxybenzamide inhibits the reaction [Morphine results in increased expression of FOS protein]; Oxaliplatin promotes the reaction [Morphine results in increased expression of FOS protein]; SCH772984 inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased expression of FOS protein]]; U 0126 inhibits the reaction [Morphine results in increased expression of FOS protein]
Agmatine inhibits the reaction [Morphine results in increased expression of FOSB protein] Morphine results in increased expression of FOSB mRNA Morphine results in increased expression of FOSB mRNA; Morphine results in increased expression of FOSB protein; Morphine results in increased expression of FOSB protein alternative form; Morphine results in increased expression of FOSB protein modified form
Morphine results in decreased expression of GNAI2 mRNA Morphine promotes the reaction [GNAI2 protein binds to RGS17 protein] Morphine results in increased expression of GNAI2 mRNA
GRIA1 protein affects the susceptibility to Morphine Morphine promotes the reaction [CREB1 protein modified form binds to GRIA1 promoter] Morphine results in increased expression of GRIA1 mRNA Morphine results in decreased expression of GRIA1 mRNA; Morphine results in decreased expression of GRIA1 protein Morphine results in decreased phosphorylation of GRIA1 protein
GRIK1 protein affects the reaction [Morphine results in increased expression of CALCA protein]; GRIK1 protein affects the reaction [Morphine results in increased expression of PDYN protein alternative form] GRIK1 protein affects the susceptibility to Morphine
[Morphine results in increased activity of OPRM1 protein] which results in increased phosphorylation of GRIN1 protein; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of GRIN1 protein] Morphine results in increased expression of GRIN1 protein Agmatine inhibits the reaction [Morphine results in increased expression of GRIN1 protein]; Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]; resveratrol inhibits the reaction [Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]]; resveratrol inhibits the reaction [Morphine results in increased expression of GRIN1 protein] Morphine results in decreased phosphorylation of GRIN1 protein Morphine affects the phosphorylation of GRIN1 protein
MMP9 protein affects the reaction [Morphine results in increased phosphorylation of GRIN2B protein] Morphine results in increased expression of GRIN2B protein Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]; resveratrol inhibits the reaction [Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]]; resveratrol inhibits the reaction [Morphine results in increased expression of GRIN2B protein]
Morphine results in increased expression of GSK3B protein modified form Naloxone inhibits the reaction [Morphine results in increased expression of GSK3B protein modified form]
HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK1 protein]]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK3 protein]]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to RAF1 protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCB protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; HINT1 gene mutant form inhibits the reaction [Morphine results in increased phosphorylation of OPRM1 protein] HINT1 gene mutant form results in increased susceptibility to Morphine
Chlorpheniramine inhibits the reaction [HRH1 results in decreased susceptibility to Morphine]; Cimetidine inhibits the reaction [HRH1 results in decreased susceptibility to Morphine]
[zolantidine binds to and results in decreased activity of HRH2 protein] which results in increased susceptibility to Morphine; Chlorpheniramine inhibits the reaction [HRH2 results in decreased susceptibility to Morphine]; Cimetidine inhibits the reaction [HRH2 results in decreased susceptibility to Morphine] HRH2 protein results in decreased susceptibility to Morphine; HRH2 results in decreased susceptibility to Morphine
Naloxone inhibits the reaction [Morphine results in increased expression of HSPA1A mRNA] Morphine results in increased expression of HSPA1A mRNA; Morphine results in increased expression of HSPA1A protein
4-(2'-methoxyphenyl)-1-(2'-(N-(2''-pyridinyl)-4-iodobenzamido)ethyl)piperazine inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Morphine]; [8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Morphine
Morphine results in decreased expression of ICAM1 protein alternative form Naloxone inhibits the reaction [Morphine results in decreased expression of ICAM1 protein alternative form]; phosphoramidon inhibits the reaction [Morphine results in decreased expression of ICAM1 protein alternative form]
Morphine results in decreased expression of IDH3B protein Morphine deficiency affects the reaction [Morphine results in decreased expression of IDH3B protein]
Carrageenan inhibits the reaction [Morphine results in decreased expression of IL1A protein]; Dexamethasone inhibits the reaction [Carrageenan inhibits the reaction [Morphine results in decreased expression of IL1A protein]]; Dexamethasone inhibits the reaction [Morphine inhibits the reaction [Carrageenan results in decreased expression of IL1A protein]]; Morphine inhibits the reaction [Carrageenan results in decreased expression of IL1A protein]; Naloxone inhibits the reaction [Carrageenan inhibits the reaction [Morphine results in decreased expression of IL1A protein]]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Carrageenan results in decreased expression of IL1A protein]]
Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [Morphine results in increased expression of IL1B mRNA]; Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [Morphine results in increased expression of IL1B protein]; resveratrol inhibits the reaction [Morphine results in increased expression of IL1B mRNA] dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Morphine results in increased expression of IL1B protein]]; Resveratrol inhibits the reaction [Morphine results in increased expression of IL1B protein] Morphine results in increased expression of IL1B mRNA; Morphine results in increased expression of IL1B protein Morphine results in increased secretion of IL1B protein
Morphine results in decreased expression of IL2 Morphine results in decreased expression of IL2 mRNA OPRM1 gene mutant form inhibits the reaction [Morphine results in decreased expression of IL2]
[FAS protein binds to FASL protein] affects the reaction [Morphine results in increased expression of IL4 protein] Morphine results in increased expression of IL4 mRNA; Morphine results in increased expression of IL4 protein CTAP octapeptide inhibits the reaction [Morphine results in increased expression of IL4 mRNA]; SB 203580 inhibits the reaction [Morphine results in increased expression of IL4 mRNA]
Morphine results in increased secretion of IL6 protein dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Morphine results in increased expression of IL6 protein]]; Resveratrol inhibits the reaction [Morphine results in increased expression of IL6 protein] Morphine results in increased expression of IL6 mRNA; Morphine results in increased expression of IL6 protein Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [Morphine results in increased expression of IL6 mRNA]; Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [Morphine results in increased expression of IL6 protein]; resveratrol inhibits the reaction [Morphine results in increased expression of IL6 mRNA]
Acetylcysteine inhibits the reaction [Morphine results in increased phosphorylation of and results in increased activity of JUN protein]; Morphine results in increased phosphorylation of and results in increased activity of JUN protein; pyrazolanthrone inhibits the reaction [Morphine results in increased phosphorylation of and results in increased activity of JUN protein]
Morphine results in increased expression of KLF7 mRNA; Morphine results in increased expression of KLF7 protein Naloxone inhibits the reaction [Morphine results in increased expression of KLF7 mRNA]
Morphine results in decreased expression of KRT2 protein Morphine deficiency affects the reaction [Morphine results in decreased expression of KRT2 protein]
Morphine deficiency inhibits the reaction [Morphine deficiency promotes the reaction [Morphine results in increased expression of KRT33A protein]]; Morphine deficiency promotes the reaction [Morphine results in increased expression of KRT33A protein]
Morphine deficiency affects the reaction [Morphine deficiency affects the reaction [Morphine results in decreased expression of KRT8 protein]]; Morphine deficiency affects the reaction [Morphine results in decreased expression of KRT8 protein]
Morphine results in increased expression of MAPK1 protein modified form Morphine results in increased phosphorylation of MAPK1 protein [Morphine co-treated with Dehydroepiandrosterone Sulfate] results in decreased phosphorylation of MAPK1 protein; AM 251 inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK1 protein]]; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; Morphine promotes the reaction [OPRM1 protein binds to MAPK1 protein]; suvorexant inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein] Morphine deficiency results in increased phosphorylation of MAPK1 protein; Morphine results in increased phosphorylation of MAPK1 protein [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of MAPK1 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; bilobalide inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased phosphorylation of MAPK1 protein]]; Oxaliplatin promotes the reaction [Morphine results in increased phosphorylation of MAPK1 protein] ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; Morphine results in increased phosphorylation of and results in increased activity of MAPK1 protein; Naloxone promotes the reaction [Morphine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]
ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; Morphine results in increased phosphorylation of and results in increased activity of MAPK3 protein; Naloxone promotes the reaction [Morphine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein] AM 251 inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK3 protein]]; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; Morphine promotes the reaction [OPRM1 protein binds to MAPK3 protein]; suvorexant inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein] Morphine deficiency results in increased phosphorylation of MAPK3 protein; Morphine results in increased phosphorylation of MAPK3 protein [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of MAPK3 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; bilobalide inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased phosphorylation of MAPK3 protein]]; Oxaliplatin promotes the reaction [Morphine results in increased phosphorylation of MAPK3 protein]
Naloxone inhibits the reaction [Morphine results in increased activity of MME protein]; phosphoramidon inhibits the reaction [Morphine results in increased activity of MME protein]
[7-nitroindazole results in decreased activity of NOS1 protein] inhibits the reaction [[Morphine co-treated with Naloxone] results in increased activity of MMP9 protein]; [Morphine co-treated with Naloxone] results in increased activity of MMP9 protein; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of GRIN1 protein]; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of GRIN2B protein]; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of MAPK3 protein] Morphine results in increased activity of MMP9 protein
Morphine results in increased phosphorylation of NFKBIA protein NFKBIA protein affects the susceptibility to Morphine Morphine results in increased expression of NFKBIA protein Morphine results in increased degradation of NFKBIA protein Morphine results in increased expression of NFKBIA mRNA; Morphine results in increased expression of NFKBIA protein Calcium affects the reaction [Morphine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]; CTAP octapeptide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]; CTAP octapeptide inhibits the reaction [Morphine results in increased expression of NFKBIA mRNA]; Cycloheximide inhibits the reaction [Morphine results in increased expression of NFKBIA mRNA]; Morphine inhibits the reaction [Doxorubicin results in increased degradation of NFKBIA protein]; Morphine inhibits the reaction [TNF protein results in increased ubiquitination of and results in increased degradation of NFKBIA protein]; USP15 mutant form inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]
[7-nitroindazole results in decreased activity of NOS1 protein] inhibits the reaction [[Morphine co-treated with Naloxone] results in increased activity of MMP9 protein] Morphine results in decreased expression of NOS1 protein PENK protein alternative form inhibits the reaction [Morphine results in increased expression of NOS1 protein]
Morphine results in increased expression of NOS2 mRNA; Morphine results in increased expression of NOS2 protein dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Morphine results in increased expression of NOS2 protein]]; NOS2 protein promotes the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of 6-Ketoprostaglandin F1 alpha]; NOS2 protein promotes the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; Resveratrol inhibits the reaction [Morphine results in increased expression of NOS2 protein] NOS2 protein affects the susceptibility to Morphine
BDNF protein inhibits the reaction [NR4A2 protein affects the susceptibility to Morphine] Morphine results in decreased expression of NR4A2 mRNA Morphine inhibits the reaction [CREB1 protein modified form binds to NR4A2 promoter]; Morphine inhibits the reaction [NR4A2 protein binds to BDNF promoter]
ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]; Morphine promotes the reaction [ARL6IP5 protein binds to OPRD1 protein]; OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein] ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]]; Morphine promotes the reaction [ARL6IP5 protein binds to OPRD1 protein] Morphine binds to OPRD1 protein
Morphine affects the activity of OPRK1 protein Morphine results in increased activity of OPRK1 protein Morphine results in increased expression of OPRK1 mRNA Morphine binds to OPRK1 protein Morphine inhibits the reaction [Zymosan results in decreased expression of OPRK1 mRNA]
[[Naloxone binds to and results in decreased activity of OPRM1 protein] which co-treated with Morphine] results in increased expression of Cyclic AMP; [[Naltrexone binds to and results in decreased activity of OPRM1 protein] which co-treated with Morphine] results in increased expression of Cyclic AMP; [COMT gene SNP co-treated with OPRM1 gene SNP] affects the susceptibility to Morphine; [OPRM1 protein co-treated with Morphine] results in increased activity of ARRB2 protein; Morphine binds to and results in increased activity of OPRM1 protein; Morphine inhibits the reaction [Tretinoin results in increased expression of OPRM1 mRNA]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Tretinoin results in increased expression of OPRM1 mRNA]]; OPRM1 protein affects the reaction [Morphine results in decreased secretion of FGF2 protein] Morphine results in increased phosphorylation of OPRM1 protein Morphine results in increased activity of OPRM1 protein Morphine results in decreased expression of OPRM1 mRNA OPRM1 affects the susceptibility to Morphine; OPRM1 protein affects the susceptibility to Morphine [Morphine results in increased activity of OPRM1 protein] which results in increased phosphorylation of GRIN1 protein; [phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Morphine; [Zymosan co-treated with Morphine] results in increased expression of OPRM1 mRNA; Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]]; Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK1 protein]]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK3 protein]]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to RAF1 protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCB protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; HINT1 gene mutant form inhibits the reaction [Morphine results in increased phosphorylation of OPRM1 protein]; Morphine affects the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]; Morphine binds to and affects the activity of OPRM1 protein; Morphine binds to and results in increased activity of OPRM1 protein; Morphine promotes the reaction [OPRM1 protein binds to MAPK1 protein]; Morphine promotes the reaction [OPRM1 protein binds to MAPK3 protein]; Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]; Morphine promotes the reaction [OPRM1 protein binds to PRKCB protein]; Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]; Morphine promotes the reaction [OPRM1 protein binds to RAF1 protein]; Naloxone inhibits the reaction [Morphine results in increased phosphorylation of OPRM1 protein]; OPRM1 gene mutant form inhibits the reaction [Morphine results in decreased expression of IFNG]; OPRM1 gene mutant form inhibits the reaction [Morphine results in decreased expression of IL2]; Tetradecanoylphorbol Acetate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; valyl-prolyl-aspartyl-prolyl-arginine inhibits the reaction [Morphine results in increased activity of OPRM1 protein] Morphine results in increased expression of OPRM1 protein Morphine binds to OPRM1 protein OPRM1 affects the activity of Morphine [beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] inhibits the reaction [Morphine results in increased abundance of 3,4-Dihydroxyphenylacetic Acid]; [beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] inhibits the reaction [Morphine results in increased abundance of Homovanillic Acid]; [beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Morphine; [Morphine binds to and results in increased activity of OPRM1 protein] which results in increased activity of ARRB2 protein; [naloxonazine binds to and results in decreased activity of OPRM1 protein] which affects the susceptibility to Morphine; [naloxonazine binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Morphine; Morphine affects the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]; Morphine binds to and affects the activity of OPRM1 protein; Morphine binds to and results in increased activity of OPRM1 protein OPRM1 exon SNP results in decreased susceptibility to Morphine Morphine affects the activity of OPRM1 protein
PDGFB protein inhibits the reaction [Morphine results in decreased expression of BCL2 protein]; PDGFB protein inhibits the reaction [Morphine results in increased activity of CASP3 protein]; PDGFB protein inhibits the reaction [Morphine results in increased expression of BAX protein] PDGFB protein results in decreased susceptibility to Morphine
Morphine results in increased expression of PDHB protein Morphine deficiency affects the reaction [Morphine results in increased expression of PDHB protein]
Morphine results in increased expression of PDYN protein alternative form Morphine deficiency results in decreased expression of PDYN mRNA Morphine results in decreased expression of PDYN mRNA [Zymosan co-treated with Morphine] results in increased expression of PDYN mRNA; GRIK1 protein affects the reaction [Morphine results in increased expression of PDYN protein alternative form]
Morphine inhibits the reaction [Formaldehyde results in increased expression of PENK mRNA]; PENK protein alternative form inhibits the reaction [Morphine results in increased expression of CALCA protein]; PENK protein alternative form inhibits the reaction [Morphine results in increased expression of NOS1 protein]; PENK protein alternative form inhibits the reaction [Morphine results in increased expression of PRKCG protein] Morphine deficiency results in decreased expression of PENK mRNA
[Fentanyl co-treated with Morphine] results in decreased expression of POMC protein alternative form Morphine deficiency results in increased secretion of POMC protein modified form [Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased secretion of POMC protein modified form]; [Morphine co-treated with Naloxone] results in increased secretion of POMC protein; Capsaicin inhibits the reaction [[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein]; Capsaicin inhibits the reaction [[Morphine co-treated with Naloxone] results in increased secretion of POMC protein] [Zymosan co-treated with Morphine] results in increased expression of POMC mRNA Morphine results in increased expression of POMC mRNA
Morphine affects the expression of PPP1R1B protein modified form ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein] ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein]; OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein]
Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]]; Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]
HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCB protein]]; Morphine promotes the reaction [OPRM1 protein binds to PRKCB protein]
PENK protein alternative form inhibits the reaction [Morphine results in increased expression of PRKCG protein] Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]] Morphine results in increased expression of PRKCG protein modified form
Morphine results in decreased expression of PTGS1 mRNA Morphine results in increased expression of PTGS1 mRNA Minocycline inhibits the reaction [Morphine results in increased expression of PTGS1 mRNA]
Morphine results in increased expression of PTGS2 protein [nimesulide results in decreased activity of PTGS2 protein] which results in increased susceptibility to Morphine [Morphine results in increased expression of PTGS2 protein] which results in increased abundance of 6-Ketoprostaglandin F1 alpha; [Morphine results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; NOS2 protein promotes the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of 6-Ketoprostaglandin F1 alpha]; NOS2 protein promotes the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; S-methylisothiopseudouronium inhibits the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of 6-Ketoprostaglandin F1 alpha]; S-methylisothiopseudouronium inhibits the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]
RAF1 protein affects the susceptibility to Morphine HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to RAF1 protein]]; Morphine promotes the reaction [OPRM1 protein binds to RAF1 protein]
Morphine inhibits the reaction [Doxorubicin affects the localization of RELA protein] Colforsin inhibits the reaction [Morphine results in increased phosphorylation of RELA protein]
Morphine results in decreased expression of SELL protein alternative form Naloxone inhibits the reaction [Morphine results in decreased expression of SELL protein alternative form]; phosphoramidon inhibits the reaction [Morphine results in decreased expression of SELL protein alternative form]
Morphine deficiency inhibits the reaction [Morphine deficiency inhibits the reaction [Morphine results in decreased expression of SEPTIN7 protein]]; Morphine deficiency inhibits the reaction [Morphine results in decreased expression of SEPTIN7 protein]
[NNC 711 results in decreased activity of SLC6A1 protein] which affects the susceptibility to Morphine SLC6A1 protein affects the susceptibility to Morphine
Morphine affects the reaction [SMPD1 protein affects the abundance of Ceramides]; Naloxone inhibits the reaction [Morphine results in increased expression of SMPD1 protein]
Morphine results in increased expression of SMPX protein Morphine deficiency affects the reaction [Morphine results in increased expression of SMPX protein]
Morphine deficiency results in increased expression of TAC1 mRNA; Morphine results in increased expression of TAC1 mRNA Morphine results in increased expression of TAC1 protein Morphine promotes the reaction [Capsaicin results in increased secretion of TAC1 protein]; Naloxone inhibits the reaction [Morphine results in increased expression of TAC1 protein]
[SR 140333 binds to and results in decreased activity of TACR1 protein] which results in increased susceptibility to Morphine; substance P-saporin inhibits the reaction [Morphine results in increased expression of TACR1 protein] Morphine results in decreased expression of TACR1 protein
Morphine results in increased expression of and results in increased localization of TGFB1 protein; TGFB1 protein affects the reaction [Morphine results in increased expression of and results in increased localization of TGFB1 protein]; TGFB1 protein affects the reaction [Morphine results in increased expression of BAX protein]
Morphine results in increased expression of TH protein [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of TH protein]; [Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein; Agmatine inhibits the reaction [Morphine results in increased expression of TH protein]; Morphine promotes the reaction [CREB1 protein modified form binds to TH promoter] Morphine results in decreased expression of TH protein [Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein; CRHR1 gene mutant form inhibits the reaction [[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein]
Morphine binds to TLR4 protein Morphine results in increased expression of TLR4 protein dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Morphine results in increased expression of TLR4 protein]]; Resveratrol inhibits the reaction [Morphine results in increased expression of TLR4 protein] Morphine affects the susceptibility to TLR4 protein Naloxone affects the reaction [Morphine binds to TLR4 protein]
Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [Morphine results in increased expression of TNF mRNA]; Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [Morphine results in increased expression of TNF protein]; Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]; Resveratrol inhibits the reaction [Morphine results in increased expression of TNF mRNA] dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Morphine results in increased expression of TNF protein]]; Resveratrol inhibits the reaction [Morphine results in increased expression of TNF protein] Calcium affects the reaction [Morphine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]; CTAP octapeptide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]; CTAP octapeptide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]]; CTAP octapeptide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]]; Cycloheximide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]]; Cycloheximide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]]; Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]; Morphine inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Morphine inhibits the reaction [TNF protein results in increased ubiquitination of and results in increased degradation of NFKBIA protein]; USP15 mutant form inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]] Morphine results in increased expression of TNF mRNA; Morphine results in increased expression of TNF protein Morphine results in increased secretion of TNF protein
[Morphine results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of BAX protein; [Morphine results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of CDKN1A protein; [Morphine results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of FAS protein; Morphine inhibits the reaction [Dactinomycin results in increased expression of TP53 protein modified form]; Morphine results in increased phosphorylation of and results in increased activity of TP53 protein; Morphine results in increased phosphorylation of and results in increased stability of TP53 protein; Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in increased expression of TP53 protein modified form]]; Naloxone inhibits the reaction [Morphine results in increased expression of TP53]; Naloxone inhibits the reaction [Morphine results in increased phosphorylation of TP53 protein] Morphine results in increased expression of TP53 mRNA
[N-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)-3-(2-(piperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)acrylamide binds to and results in decreased activity of TRPV1 protein] which results in decreased susceptibility to Morphine Morphine affects the activity of TRPV1 protein Morphine results in increased expression of TRPV1; Morphine results in increased expression of TRPV1 protein TRPV1 protein affects the susceptibility to Morphine
Morphine results in decreased expression of TTR protein Morphine deficiency affects the reaction [Morphine results in decreased expression of TTR protein]
UGT2B7 affects the metabolism of Morphine; UGT2B7 protein affects the metabolism of Morphine UGT2B7 protein results in increased glucuronidation of Morphine
Calcium affects the reaction [Morphine results in increased expression of USP15 mRNA]; CTAP octapeptide inhibits the reaction [Morphine results in increased expression of USP15 mRNA]; USP15 mutant form inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]] Morphine results in increased expression of USP15 mRNA; Morphine results in increased expression of USP15 protein
CYP2D6 protein affects the metabolism of Codeine; CYP2D6 protein polymorphism affects the metabolism of Codeine [CYP2D6 gene mutant form results in increased activity of CYP2D6 protein] which results in increased susceptibility to Codeine; [CYP2D6 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of Morphine [CYP2D22 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of norcodeine CYP2D6 protein polymorphism affects the susceptibility to Codeine CYP2D6 protein results in decreased methylation of Codeine CYP2D6 gene polymorphism results in increased metabolism of Codeine; CYP2D6 protein results in increased metabolism of Codeine
CYP3A4 protein affects the metabolism of Codeine CYP3A4 protein results in increased metabolism of Codeine [CYP3A4 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of norcodeine
Heroin results in decreased expression of BDNF protein Heroin inhibits the reaction [CREB1 protein modified form binds to BDNF promoter] Heroin results in decreased expression of BDNF mRNA
[Heroin co-treated with Cocaine] results in increased activity of CASP3 protein; Heroin promotes the reaction [Cocaine results in increased activity of CASP3 protein]
CES1 protein results in decreased acetylation of Heroin Heroin binds to CES1 protein Cocaine inhibits the reaction [CES1 protein results in increased hydrolysis of Heroin]
Heroin results in increased expression of FOS mRNA; Heroin results in increased expression of FOS protein Dronabinol affects the reaction [Heroin results in increased expression of FOS protein]
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