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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:homoserine lactone
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Accession:CHEBI:17289 term browser browse the term
Definition:A butan-4-olide having an amino substituent at the 2-position.
Synonyms:exact_synonym: 3-amino-4,5-dihydrofuran-2(3H)-one
 related_synonym: 2-Aminobutan-4-olide;   Formula=C4H7NO2;   HSL;   HSLs;   InChI=1S/C4H7NO2/c5-3-1-2-7-4(3)6/h3H,1-2,5H2;   InChIKey=QJPWUUJVYOJNMH-UHFFFAOYSA-N;   SMILES=NC1CCOC1=O;   alpha-amino-gamma-butyrolactone
 alt_id: CHEBI:1017;   CHEBI:11522;   CHEBI:19468;   CHEBI:30656
 xref: Beilstein:80584;   CAS:1192-20-7;   DrugBank:DB02624;   KEGG:C02926;   MetaCyc:HOMOSERINE-LACTONE;   PMID:7545940;   Reaxys:80584
 cyclic_relationship: is_conjugate_base_of CHEBI:58093


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N-(3-oxododecanoyl)homoserine lactone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO N-(3-oxododecanoyl)homoserine lactone results in increased activity of CASP3 protein CTD PMID:25627690 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 increases activity ISO N-(3-oxododecanoyl)homoserine lactone results in increased activity of CASP7 protein CTD PMID:25627690 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G P2ry2 purinergic receptor P2Y2 multiple interactions
decreases expression
ISO Ibuprofen inhibits the reaction [N-(3-oxododecanoyl)homoserine lactone results in decreased expression of P2RY2 mRNA] CTD PMID:10496880 NCBI chr 1:166,031,228...166,045,423
Ensembl chr 1:166,031,272...166,037,424
JBrowse link
G P2ry4 pyrimidinergic receptor P2Y4 decreases expression ISO N-(3-oxododecanoyl)homoserine lactone results in decreased expression of P2RY4 mRNA CTD PMID:10496880 NCBI chr  X:70,421,599...70,447,109
Ensembl chr  X:70,426,951...70,428,364
JBrowse link
G Pon2 paraoxonase 2 increases response to substance ISO PON2 protein results in increased susceptibility to N-(3-oxododecanoyl)homoserine lactone CTD PMID:25627690 NCBI chr 4:30,344,705...30,380,119
Ensembl chr 4:30,344,709...30,380,119
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      application 19426
        refrigerant 17439
          ammonia 16959
            organic amino compound 16958
              primary amino compound 7872
                homoserine lactone 5
                  D-homoserine lactone 0
                  L-homoserine lactone + 0
                  N-acyl homoserine lactone + 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic ester 14365
                                        lactone 5982
                                          gamma-lactone 1216
                                            butan-4-olide 308
                                              homoserine lactone 5
                                                D-homoserine lactone 0
                                                L-homoserine lactone + 0
                                                N-acyl homoserine lactone + 5
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