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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:homoserine lactone
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Accession:CHEBI:17289 term browser browse the term
Definition:A butan-4-olide having an amino substituent at the 2-position.
Synonyms:exact_synonym: 3-amino-4,5-dihydrofuran-2(3H)-one
 related_synonym: 2-Aminobutan-4-olide;   Formula=C4H7NO2;   HSL;   HSLs;   InChI=1S/C4H7NO2/c5-3-1-2-7-4(3)6/h3H,1-2,5H2;   InChIKey=QJPWUUJVYOJNMH-UHFFFAOYSA-N;   SMILES=NC1CCOC1=O;   alpha-amino-gamma-butyrolactone
 alt_id: CHEBI:1017;   CHEBI:11522;   CHEBI:19468;   CHEBI:30656
 xref: Beilstein:80584;   CAS:1192-20-7;   DrugBank:DB02624;   KEGG:C02926;   MetaCyc:HOMOSERINE-LACTONE;   PMID:7545940;   Reaxys:80584
 cyclic_relationship: is_conjugate_base_of CHEBI:58093


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N-(3-oxododecanoyl)homoserine lactone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO N-(3-oxododecanoyl)homoserine lactone results in increased activity of CASP3 protein CTD PMID:25627690 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 increases activity ISO N-(3-oxododecanoyl)homoserine lactone results in increased activity of CASP7 protein CTD PMID:25627690 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G P2ry2 purinergic receptor P2Y2 multiple interactions
decreases expression
ISO Ibuprofen inhibits the reaction [N-(3-oxododecanoyl)homoserine lactone results in decreased expression of P2RY2 mRNA] CTD PMID:10496880 NCBI chr 1:155,352,050...155,367,423
Ensembl chr 1:155,351,165...155,367,632
JBrowse link
G P2ry4 pyrimidinergic receptor P2Y4 decreases expression ISO N-(3-oxododecanoyl)homoserine lactone results in decreased expression of P2RY4 mRNA CTD PMID:10496880 NCBI chr  X:65,681,680...65,717,404
Ensembl chr  X:65,683,232...65,721,748
JBrowse link
G Pon2 paraoxonase 2 increases response to substance ISO PON2 protein results in increased susceptibility to N-(3-oxododecanoyl)homoserine lactone CTD PMID:25627690 NCBI chr 4:33,389,702...33,425,186
Ensembl chr 4:33,389,714...33,425,248
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      application 19481
        refrigerant 17694
          ammonia 17278
            organic amino compound 17278
              primary amino compound 7952
                homoserine lactone 5
                  D-homoserine lactone 0
                  L-homoserine lactone + 0
                  N-acyl homoserine lactone + 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic ester 15884
                                        lactone 11242
                                          gamma-lactone 6740
                                            butan-4-olide 308
                                              homoserine lactone 5
                                                D-homoserine lactone 0
                                                L-homoserine lactone + 0
                                                N-acyl homoserine lactone + 5
paths to the root