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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:homoserine lactone
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Accession:CHEBI:17289 term browser browse the term
Definition:A butan-4-olide having an amino substituent at the 2-position.
Synonyms:exact_synonym: 3-amino-4,5-dihydrofuran-2(3H)-one
 related_synonym: 2-Aminobutan-4-olide;   Formula=C4H7NO2;   HSL;   HSLs;   InChI=1S/C4H7NO2/c5-3-1-2-7-4(3)6/h3H,1-2,5H2;   InChIKey=QJPWUUJVYOJNMH-UHFFFAOYSA-N;   SMILES=NC1CCOC1=O;   alpha-amino-gamma-butyrolactone
 alt_id: CHEBI:1017;   CHEBI:11522;   CHEBI:19468;   CHEBI:30656
 xref: Beilstein:80584;   CAS:1192-20-7;   DrugBank:DB02624;   KEGG:C02926;   MetaCyc:HOMOSERINE-LACTONE;   PMID:7545940;   Reaxys:80584
 cyclic_relationship: is_conjugate_base_of CHEBI:58093



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N-(3-oxododecanoyl)homoserine lactone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO N-(3-oxododecanoyl)homoserine lactone results in increased activity of CASP3 protein CTD PMID:25627690 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 increases activity ISO N-(3-oxododecanoyl)homoserine lactone results in increased activity of CASP7 protein CTD PMID:25627690 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G P2ry2 purinergic receptor P2Y2 multiple interactions
decreases expression
ISO Ibuprofen inhibits the reaction [N-(3-oxododecanoyl)homoserine lactone results in decreased expression of P2RY2 mRNA] CTD PMID:10496880 NCBI chr 1:155,352,050...155,367,423
Ensembl chr 1:155,351,165...155,367,632
JBrowse link
G P2ry4 pyrimidinergic receptor P2Y4 decreases expression ISO N-(3-oxododecanoyl)homoserine lactone results in decreased expression of P2RY4 mRNA CTD PMID:10496880 NCBI chr  X:65,681,680...65,717,404
Ensembl chr  X:65,683,232...65,721,748
JBrowse link
G Pon2 paraoxonase 2 increases response to substance ISO PON2 protein results in increased susceptibility to N-(3-oxododecanoyl)homoserine lactone CTD PMID:25627690 NCBI chr 4:33,389,702...33,425,186
Ensembl chr 4:33,389,714...33,425,248
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      application 19745
        refrigerant 18065
          ammonia 17502
            organic amino compound 17502
              primary amino compound 8282
                homoserine lactone 5
                  D-homoserine lactone 0
                  L-homoserine lactone + 0
                  N-acyl homoserine lactone + 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic group 18961
                              organic divalent group 18947
                                organodiyl group 18947
                                  carbonyl group 18900
                                    carbonyl compound 18900
                                      carboxylic ester 15933
                                        lactone 11283
                                          gamma-lactone 6802
                                            butan-4-olide 307
                                              homoserine lactone 5
                                                D-homoserine lactone 0
                                                L-homoserine lactone + 0
                                                N-acyl homoserine lactone + 5
paths to the root