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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:N-phosphocreatine
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Accession:CHEBI:17287 term browser browse the term
Definition:A phosphoamino acid consisting of creatine having a phospho group attached at the primary nitrogen of the guanidino group.
Synonyms:exact_synonym: N-[imino(phosphonoamino)methyl]-N-methylglycine
 related_synonym: Creatine phosphate;   Creatine phosphic acid;   Formula=C4H10N3O5P;   InChI=1S/C4H10N3O5P/c1-7(2-3(8)9)4(5)6-13(10,11)12/h2H2,1H3,(H,8,9)(H4,5,6,10,11,12);   InChIKey=DRBBFCLWYRJSJZ-UHFFFAOYSA-N;   N(omega)-phosphonocreatine;   N-(N-phosphonoamido)sarcosine;   N-(Phosphonoamidino)sarcosine;   N-Phosphorylcreatine;   Phosphocreatine;   SMILES=CN(CC(O)=O)C(=N)NP(O)(O)=O;   phosphorylcreatine;   {[imino(phosphonoamino)methyl](methyl)amino}acetic acid
 alt_id: CHEBI:12526;   CHEBI:14813;   CHEBI:26053;   CHEBI:8145
 xref: CAS:67-07-2;   Drug_Central:3464;   HMDB:HMDB0001511;   KEGG:C02305
 xref_mesh: MESH:D010725
 xref: MetaCyc:CREATINE-P;   PMID:1160340;   PMID:11867929;   PMID:13772879;   PMID:13881337;   PMID:14421251;   PMID:5879486;   Reaxys:1797096;   Wikipedia:Phosphocreatine
 cyclic_relationship: is_conjugate_acid_of CHEBI:58092


show annotations for term's descendants           Sort by:
N-phosphocreatine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Phosphocreatine inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]]; Phosphocreatine inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein] CTD PMID:37648050 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP
ISO 		Phosphocreatine inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; Phosphocreatine inhibits the reaction [Pyruvaldehyde results in increased expression of BAX protein]; Phosphocreatine inhibits the reaction [Streptozocin results in increased expression of BAX protein]
Phosphocreatine inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein] 		CTD PMID:34358621 PMID:34455488 PMID:37597758 PMID:37648050 PMID:39043266 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions
decreases expression 		EXP Phosphocreatine inhibits the reaction [Doxorubicin results in increased expression of BBC3 mRNA]; Phosphocreatine inhibits the reaction [Doxorubicin results in increased expression of BBC3 protein]
Phosphocreatine results in decreased expression of BBC3 mRNA; Phosphocreatine results in decreased expression of BBC3 protein 		CTD PMID:37597758 NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP
ISO 		Phosphocreatine inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Phosphocreatine inhibits the reaction [Pyruvaldehyde results in decreased expression of BCL2 protein]; Phosphocreatine inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein]
Phosphocreatine inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein] 		CTD PMID:34455488 PMID:37648050 PMID:39043266 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO 		7-oxozeanol inhibits the reaction [Phosphocreatine inhibits the reaction [Doxorubicin results in increased cleavage of CASP3 protein]]; Phosphocreatine inhibits the reaction [Doxorubicin results in increased cleavage of CASP3 protein]; Phosphocreatine inhibits the reaction [Pyruvaldehyde results in decreased expression of CASP3 protein]; Phosphocreatine inhibits the reaction [Pyruvaldehyde results in increased expression of CASP3 protein modified form]; Phosphocreatine inhibits the reaction [Streptozocin results in decreased expression of CASP3 protein]; Phosphocreatine inhibits the reaction [Streptozocin results in increased expression of CASP3 protein modified form]
Phosphocreatine inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 protein] 		CTD PMID:34358621 PMID:34455488 PMID:37597758 PMID:37648050 PMID:39043266 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions EXP
ISO 		Phosphocreatine inhibits the reaction [Pyruvaldehyde results in decreased expression of CASP9 protein]; Phosphocreatine inhibits the reaction [Streptozocin results in decreased expression of CASP9 protein]
Phosphocreatine inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP9 protein] 		CTD PMID:34455488 PMID:37648050 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions EXP Phosphocreatine promotes the reaction [Doxorubicin results in decreased expression of CTGF mRNA] CTD PMID:37597758 NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Ctnnd1 catenin delta 1 multiple interactions EXP Phosphocreatine promotes the reaction [Doxorubicin results in decreased expression of CTNND1 mRNA] CTD PMID:37597758 NCBI chr 3:69,683,328...69,734,550
Ensembl chr 3:69,683,313...69,734,516 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP Phosphocreatine inhibits the reaction [Doxorubicin affects the localization of CYCS protein]; Phosphocreatine inhibits the reaction [Pyruvaldehyde results in increased expression of CYCS protein]; Phosphocreatine inhibits the reaction [Streptozocin results in increased expression of CYCS protein] CTD PMID:34455488 PMID:39043266 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Foxo3 forkhead box O3 multiple interactions EXP Phosphocreatine inhibits the reaction [Doxorubicin results in decreased expression of FOXO3 protein] CTD PMID:34358621 NCBI chr20:47,251,968...47,348,254
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP Phosphocreatine inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of GSK3B protein]; Phosphocreatine inhibits the reaction [Pyruvaldehyde results in decreased phosphorylation of GSK3B protein]; Phosphocreatine inhibits the reaction [Streptozocin results in decreased phosphorylation of GSK3B protein] CTD PMID:34455488 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions EXP Phosphocreatine promotes the reaction [Doxorubicin results in decreased expression of IGF1R mRNA] CTD PMID:37597758 NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Ins1 insulin 1 multiple interactions EXP Phosphocreatine inhibits the reaction [Pyruvaldehyde results in decreased secretion of INS1 protein]; Phosphocreatine inhibits the reaction [Streptozocin results in decreased secretion of INS1 protein] CTD PMID:34455488 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions EXP Phosphocreatine inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of IRS1 protein]; Phosphocreatine inhibits the reaction [Pyruvaldehyde results in decreased phosphorylation of IRS1 protein]; Phosphocreatine inhibits the reaction [Streptozocin results in decreased phosphorylation of IRS1 protein] CTD PMID:34455488 NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Lpl lipoprotein lipase multiple interactions EXP Phosphocreatine inhibits the reaction [Dietary Fats results in decreased activity of LPL protein] CTD PMID:37648050 NCBI chr16:25,596,205...25,621,928
Ensembl chr16:20,829,465...20,855,249 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 multiple interactions EXP 7-oxozeanol inhibits the reaction [Phosphocreatine inhibits the reaction [Doxorubicin results in decreased expression of MAP3K7 protein]]; Phosphocreatine inhibits the reaction [Doxorubicin results in decreased expression of MAP3K7 protein]; Phosphocreatine inhibits the reaction [Doxorubicin results in increased expression of MAP3K7 protein] CTD PMID:34358621 NCBI chr 5:51,149,524...51,212,012
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Mapk7 mitogen-activated protein kinase 7 decreases expression
multiple interactions 		EXP Phosphocreatine results in decreased expression of MAPK7 mRNA
Phosphocreatine inhibits the reaction [Doxorubicin results in increased expression of MAPK7 mRNA] 		CTD PMID:37597758 NCBI chr10:46,669,721...46,675,768
Ensembl chr10:46,170,167...46,176,267 		JBrowse link
G Mapt microtubule-associated protein tau decreases abundance
multiple interactions 		ISO MAPT protein mutant form results in decreased abundance of Phosphocreatine
PF-06840003 inhibits the reaction [MAPT protein mutant form results in decreased abundance of Phosphocreatine] 		CTD PMID:39172838 NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Mir143 microRNA 143 multiple interactions
increases expression 		EXP Phosphocreatine inhibits the reaction [Doxorubicin results in decreased expression of MIR143 mRNA]
Phosphocreatine results in increased expression of MIR143 mRNA 		CTD PMID:37597758 NCBI chr18:55,101,006...55,101,110
Ensembl chr18:55,101,006...55,101,110 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP Phosphocreatine affects the reaction [Doxorubicin affects the expression of NFE2L2 protein]; Phosphocreatine inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein] CTD PMID:34358621 PMID:37597758 PMID:39043266 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Pdgfra platelet derived growth factor receptor alpha decreases expression
multiple interactions 		EXP Phosphocreatine results in decreased expression of PDGFRA mRNA
Phosphocreatine inhibits the reaction [Doxorubicin results in increased expression of PDGFRA mRNA] 		CTD PMID:37597758 NCBI chr14:33,360,027...33,408,604
Ensembl chr14:33,005,839...33,054,335 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions EXP Phosphocreatine inhibits the reaction [Doxorubicin results in decreased expression of PPARGC1A protein] CTD PMID:39043266 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Ppid peptidylprolyl isomerase D multiple interactions EXP Phosphocreatine inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of PPID protein]; Phosphocreatine inhibits the reaction [Pyruvaldehyde results in increased expression of PPID protein]; Phosphocreatine inhibits the reaction [Streptozocin results in increased expression of PPID protein] CTD PMID:34455488 NCBI chr 2:167,025,985...167,037,998
Ensembl chr 2:164,727,779...164,740,221 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression 		EXP Phosphocreatine inhibits the reaction [Doxorubicin results in increased expression of PTGS2 mRNA]
Phosphocreatine results in decreased expression of PTGS2 mRNA 		CTD PMID:37597758 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 multiple interactions EXP Phosphocreatine inhibits the reaction [Doxorubicin results in increased expression of RIPK3 protein] CTD PMID:34358621 NCBI chr15:33,253,071...33,262,025
Ensembl chr15:29,283,145...29,292,121 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP Phosphocreatine inhibits the reaction [Doxorubicin results in decreased expression of SOD2 protein] CTD PMID:37597758 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sod3 superoxide dismutase 3 multiple interactions EXP Phosphocreatine inhibits the reaction [Doxorubicin results in decreased expression of SOD3 protein] CTD PMID:34358621 NCBI chr14:62,822,865...62,828,602
Ensembl chr14:58,609,958...58,615,990 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases response to substance
multiple interactions 		EXP STAT3 protein results in increased susceptibility to Phosphocreatine
Phosphocreatine inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased phosphorylation of STAT3 protein]; Phosphocreatine inhibits the reaction [Pyruvaldehyde results in increased phosphorylation of STAT3 protein]; Phosphocreatine inhibits the reaction [Streptozocin results in increased phosphorylation of STAT3 protein] 		CTD PMID:34455488 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
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  CHEBI ontology 20856
    role 20816
      application 20617
        pharmaceutical 20413
          drug 20413
            nutraceutical 13836
              creatine 44
                N-phosphocreatine 28
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  CHEBI ontology 20856
    subatomic particle 20854
      composite particle 20854
        hadron 20854
          baryon 20854
            nucleon 20854
              atomic nucleus 20854
                atom 20854
                  main group element atom 20777
                    main group molecular entity 20777
                      s-block molecular entity 20573
                        hydrogen molecular entity 20557
                          hydrides 19691
                            inorganic hydride 18601
                              pnictogen hydride 18587
                                nitrogen hydride 18502
                                  azane 18261
                                    ammonia 18260
                                      organic amino compound 18260
                                        amino acid 16329
                                          alpha-amino acid 14212
                                            serine family amino acid 6047
                                              glycine 3372
                                                glycine derivative 3360
                                                  creatine 44
                                                    N-phosphocreatine 28
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