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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:phloretin
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Accession:CHEBI:17276 term browser browse the term
Definition:A member of the class of dihydrochalcones that is dihydrochalcone substituted by hydroxy groups at positions 4, 2', 4' and 6'.
Synonyms:exact_synonym: 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one
 related_synonym: 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone;   Formula=C15H14O5;   InChI=1S/C15H14O5/c16-10-4-1-9(2-5-10)3-6-12(18)15-13(19)7-11(17)8-14(15)20/h1-2,4-5,7-8,16-17,19-20H,3,6H2;   InChIKey=VGEREEWJJVICBM-UHFFFAOYSA-N;   SMILES=Oc1ccc(CCC(=O)c2c(O)cc(O)cc2O)cc1
 alt_id: CHEBI:14787;   CHEBI:26014;   CHEBI:42649;   CHEBI:8111
 xref: CAS:60-82-2;   DrugBank:DB07810;   HMDB:HMDB0003306;   KEGG:C00774;   KNApSAcK:C00007936;   LINCS:LSM-6221;   LIPID_MAPS_instance:LMPK12120525
 xref_mesh: MESH:D010693
 xref: MetaCyc:PHLORETIN;   PDBeChem:G50;   PMID:18767070;   PMID:23907072;   PMID:24487097;   PMID:7126563;   Patent:CN102701938;   Patent:CN103230408;   Reaxys:1887240;   Wikipedia:Phloretin


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phloretin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afp alpha-fetoprotein affects binding EXP Phloretin binds to AFP protein CTD PMID:23013281, PMID:25349334 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
JBrowse link
G Aqp9 aquaporin 9 multiple interactions
decreases activity
EXP
ISO
Phloretin inhibits the reaction [AQP9 protein results in increased transport of Water]; Phloretin inhibits the reaction [CFTR protein promotes the reaction [AQP9 protein affects the transport of Water]]
Phloretin inhibits the reaction [AQP9 protein results in increased uptake of Lactic Acid]; Phloretin inhibits the reaction [AQP9 protein results in increased uptake of Selenic Acid analog]; Phloretin inhibits the reaction [AQP9 protein results in increased uptake of Selenious Acid]
Phloretin results in decreased activity of AQP9 protein
CTD PMID:9733774, PMID:12606488, PMID:21259319, PMID:28798983 NCBI chr 8:77,559,621...77,599,781
Ensembl chr 8:77,559,624...77,599,781
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Phloretin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein] CTD PMID:24707119 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Phloretin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL5 protein] CTD PMID:24707119 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions EXP Phloretin inhibits the reaction [CFTR protein promotes the reaction [AQP9 protein affects the transport of Water]] CTD PMID:12606488 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Csf3 colony stimulating factor 3 multiple interactions ISO Phloretin inhibits the reaction [Lipopolysaccharides results in increased expression of CSF3 protein] CTD PMID:24707119 NCBI chr10:86,616,785...86,619,160
Ensembl chr10:86,616,785...86,619,157
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Phloretin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Phloretin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Phloretin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein] CTD PMID:17177569 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Phloretin binds to and results in increased activity of ESR1 protein CTD PMID:9751507 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
affects binding
ISO Phloretin binds to and results in increased activity of ESR2 protein
Phloretin binds to ESR2 protein
CTD PMID:9751507, PMID:12224631 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO Phloretin inhibits the reaction [Acetaminophen results in increased activity of GPT protein] CTD PMID:30287234 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases activity ISO Phloretin results in decreased activity of GSK3B protein CTD PMID:16968061 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Ifng interferon gamma multiple interactions ISO Phloretin inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein] CTD PMID:24707119 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Phloretin inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein] CTD PMID:24707119 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Phloretin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A protein] CTD PMID:24707119 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Phloretin inhibits the reaction [Uric Acid results in increased secretion of IL1B protein] CTD PMID:21051542 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions ISO Phloretin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1RN protein] CTD PMID:24707119 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Phloretin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:24707119 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ins2 insulin 2 multiple interactions ISO Phloretin inhibits the reaction [[chromic chloride results in increased activity of INS protein modified form] which results in increased secretion of Adenosine Triphosphate] CTD PMID:17965850 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 affects response to substance EXP KCNMA1 mRNA affects the susceptibility to Phloretin CTD PMID:19247476 NCBI chr15:344,204...1,048,849
Ensembl chr15:344,360...1,047,956
JBrowse link
G Ltf lactotransferrin increases expression EXP Phloretin results in increased expression of LTF protein CTD PMID:24487097 NCBI chr 8:119,290,416...119,313,261
Ensembl chr 8:119,290,416...119,313,261
JBrowse link
G Nos3 nitric oxide synthase 3 decreases expression
multiple interactions
ISO Phloretin results in decreased expression of NOS3 mRNA
Phloretin inhibits the reaction [Hydrogen Peroxide results in increased expression of NOS3 mRNA]
CTD PMID:20021702 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Shbg sex hormone binding globulin affects binding ISO Phloretin binds to SHBG protein CTD PMID:25349334 NCBI chr10:56,219,861...56,237,354
Ensembl chr10:56,219,858...56,223,245
JBrowse link
G Slc14a1 solute carrier family 14 member 1 (Kidd blood group) multiple interactions EXP Phloretin inhibits the reaction [SLC14A1 protein results in increased transport of Urea] CTD PMID:8982255 NCBI chr18:74,461,064...74,504,475
Ensembl chr18:74,461,055...74,485,139
JBrowse link
G Slc14a2 solute carrier family 14 member 2 multiple interactions EXP Phloretin inhibits the reaction [SLC14A2 protein results in increased transport of Urea] CTD PMID:11181411 NCBI chr18:74,508,070...74,941,389
Ensembl chr18:74,546,220...74,688,551
Ensembl chr18:74,546,220...74,688,551
JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions EXP [[Luteolin co-treated with Phloretin] results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate; [Phloretin results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate CTD PMID:17108059 NCBI chr 2:207,108,552...207,129,352
Ensembl chr 2:207,108,552...207,128,554
JBrowse link
G Slc16a2 solute carrier family 16 member 2 multiple interactions ISO Phloretin inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine] CTD PMID:28119167 NCBI chr  X:74,578,600...74,706,068
Ensembl chr  X:74,577,131...74,706,214
JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions
decreases activity
ISO Phloretin inhibits the reaction [SLC2A1 protein affects the transport of Glucose]
Phloretin results in decreased activity of SLC2A1 protein
CTD PMID:14642735 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Slc2a2 solute carrier family 2 member 2 multiple interactions
decreases expression
ISO
EXP
Phloretin inhibits the reaction [Fluorouracil promotes the reaction [SLC2A2 protein results in increased uptake of 3-O-Methylglucose]]; Phloretin inhibits the reaction [SLC2A2 protein results in increased uptake of 3-O-Methylglucose]
Phloretin results in decreased expression of SLC2A2 protein
Phloretin inhibits the reaction [SLC2A2 protein results in increased uptake of Glucose]
CTD PMID:15986457, PMID:17272349, PMID:26616219 NCBI chr 2:114,413,427...114,445,418
Ensembl chr 2:114,413,410...114,445,395
JBrowse link
G Slc2a9 solute carrier family 2 member 9 multiple interactions ISO Phloretin inhibits the reaction [SLC2A9 protein results in increased uptake of Uric Acid] CTD PMID:19587147 NCBI chr14:77,067,537...77,192,702
Ensembl chr14:77,067,503...77,192,702
JBrowse link
G Slc9a1 solute carrier family 9 member A1 multiple interactions
decreases activity
ISO Phloretin inhibits the reaction [SLC9A1 protein alternative form affects the transport of [Sodium co-treated with Lithium]]
Phloretin results in decreased activity of SLC9A1 protein; Phloretin results in decreased activity of SLC9A1 protein alternative form
CTD PMID:12765964 NCBI chr 5:151,573,122...151,626,360
Ensembl chr 5:151,573,092...151,627,316
JBrowse link
G Slc9b2 solute carrier family 9 member B2 decreases activity ISO Phloretin results in decreased activity of SLC9B2 protein CTD PMID:18000046 NCBI chr 2:240,485,254...240,519,166
Ensembl chr 2:240,495,371...240,519,141
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of Phloretin CTD PMID:14557274 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
phlorizin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abat 4-aminobutyrate aminotransferase decreases expression ISO Phlorhizin results in decreased expression of ABAT mRNA CTD PMID:22538082 NCBI chr10:7,093,406...7,200,439
Ensembl chr10:7,093,405...7,200,499
JBrowse link
G Acaa1b acetyl-Coenzyme A acyltransferase 1B increases expression ISO Phlorhizin results in increased expression of ACAA1 mRNA CTD PMID:22538082 NCBI chr 8:127,836,235...127,845,296 JBrowse link
G Acaa2 acetyl-CoA acyltransferase 2 decreases expression ISO Phlorhizin results in decreased expression of ACAA2 mRNA CTD PMID:22538082 NCBI chr18:70,733,872...70,762,395
Ensembl chr18:70,733,872...70,762,395
JBrowse link
G Acad8 acyl-CoA dehydrogenase family, member 8 decreases expression ISO Phlorhizin results in decreased expression of ACAD8 mRNA CTD PMID:22538082 NCBI chr 8:28,023,401...28,044,967
Ensembl chr 8:28,024,123...28,044,876
JBrowse link
G Acad9 acyl-CoA dehydrogenase family, member 9 decreases expression ISO Phlorhizin results in decreased expression of ACAD9 mRNA CTD PMID:22538082 NCBI chr 2:122,782,051...122,806,166
Ensembl chr 2:122,782,060...122,805,768
JBrowse link
G Acadl acyl-CoA dehydrogenase, long chain decreases expression ISO Phlorhizin results in decreased expression of ACADL mRNA CTD PMID:22538082 NCBI chr 9:73,833,368...73,871,857
Ensembl chr 9:73,833,388...73,871,888
JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain decreases expression ISO Phlorhizin results in decreased expression of ACADM mRNA CTD PMID:22538082 NCBI chr 2:260,124,418...260,148,589
Ensembl chr 2:260,124,418...260,148,589
JBrowse link
G Acat1 acetyl-CoA acetyltransferase 1 decreases expression ISO Phlorhizin results in decreased expression of ACAT1 mRNA CTD PMID:22538082 NCBI chr 8:58,166,990...58,195,884
Ensembl chr 8:58,166,990...58,195,884
JBrowse link
G Aco1 aconitase 1 decreases expression ISO Phlorhizin results in decreased expression of ACO1 mRNA CTD PMID:22538082 NCBI chr 5:56,425,076...56,481,218
Ensembl chr 5:56,425,024...56,481,218
JBrowse link
G Acox1 acyl-CoA oxidase 1 decreases expression ISO Phlorhizin results in decreased expression of ACOX1 mRNA CTD PMID:22538082 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
JBrowse link
G Acox2 acyl-CoA oxidase 2 decreases expression ISO Phlorhizin results in decreased expression of ACOX2 mRNA CTD PMID:22538082 NCBI chr15:18,449,304...18,481,472
Ensembl chr15:18,451,144...18,481,470
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 decreases expression ISO Phlorhizin results in decreased expression of ACSL1 mRNA CTD PMID:22538082 NCBI chr16:48,937,456...49,003,898
Ensembl chr16:48,937,456...49,003,246
JBrowse link
G Actb actin, beta increases expression ISO Phlorhizin results in increased expression of ACTB mRNA CTD PMID:22538082 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
JBrowse link
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide decreases expression ISO Phlorhizin results in decreased expression of ADH5 mRNA CTD PMID:22538082 NCBI chr 2:243,728,500...243,740,907
Ensembl chr 2:243,700,784...243,740,899
JBrowse link
G Adhfe1 alcohol dehydrogenase, iron containing, 1 decreases expression ISO Phlorhizin results in decreased expression of ADHFE1 mRNA CTD PMID:22538082 NCBI chr 5:9,403,194...9,429,783
Ensembl chr 5:9,403,196...9,429,859
JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 decreases expression ISO Phlorhizin results in decreased expression of AKR1A1 mRNA CTD PMID:22538082 NCBI chr 5:135,482,068...135,498,693
Ensembl chr 5:135,482,068...135,498,822
JBrowse link
G Akr7a2 aldo-keto reductase family 7, member A2 increases expression ISO Phlorhizin results in increased expression of AKR7A2 mRNA CTD PMID:22538082 NCBI chr 5:157,759,448...157,768,473
Ensembl chr 5:157,759,416...157,768,471
JBrowse link
G Alb albumin multiple interactions ISO Phlorhizin inhibits the reaction [Glucose results in decreased uptake of ALB protein] CTD PMID:16313995 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member decreases expression
increases expression
ISO Phlorhizin results in decreased expression of ALDH2 mRNA
Phlorhizin results in increased expression of ALDH2 mRNA
CTD PMID:22538082 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 decreases expression ISO Phlorhizin results in decreased expression of ALDH3A2 mRNA CTD PMID:22538082 NCBI chr10:47,525,486...47,546,535
Ensembl chr10:47,525,493...47,546,345
JBrowse link
G Aldh4a1 aldehyde dehydrogenase 4 family, member A1 decreases expression ISO Phlorhizin results in decreased expression of ALDH4A1 mRNA CTD PMID:22538082 NCBI chr 5:158,090,238...158,115,725
Ensembl chr 5:158,042,587...158,135,733
JBrowse link
G Aldh6a1 aldehyde dehydrogenase 6 family, member A1 decreases expression ISO Phlorhizin results in decreased expression of ALDH6A1 mRNA CTD PMID:22538082 NCBI chr 6:108,146,552...108,167,185
Ensembl chr 6:108,146,582...108,167,185
JBrowse link
G Aldh7a1 aldehyde dehydrogenase 7 family, member A1 decreases expression ISO Phlorhizin results in decreased expression of ALDH7A1 mRNA CTD PMID:22538082 NCBI chr18:51,619,007...51,651,267
Ensembl chr18:51,619,007...51,651,267
JBrowse link
G Anapc2 anaphase promoting complex subunit 2 decreases expression ISO Phlorhizin results in decreased expression of ANAPC2 mRNA CTD PMID:22538082 NCBI chr 3:2,490,496...2,502,247
Ensembl chr 3:2,490,518...2,502,248
JBrowse link
G Anapc5 anaphase-promoting complex subunit 5 decreases expression ISO Phlorhizin results in decreased expression of ANAPC5 mRNA CTD PMID:22538082 NCBI chr12:39,209,134...39,242,696
Ensembl chr12:39,209,129...39,242,690
JBrowse link
G Aox1 aldehyde oxidase 1 decreases expression ISO Phlorhizin results in decreased expression of AOX1 mRNA CTD PMID:22538082 NCBI chr 9:64,929,682...65,007,872
Ensembl chr 9:64,929,721...65,007,870
JBrowse link
G Aph1b aph-1 homolog B, gamma secretase subunit increases expression ISO Phlorhizin results in increased expression of APH1B mRNA CTD PMID:22538082 NCBI chr 8:72,508,008...72,598,921
Ensembl chr 8:72,476,425...72,629,265
JBrowse link
G App amyloid beta precursor protein decreases expression ISO Phlorhizin results in decreased expression of APP mRNA CTD PMID:22538082 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Atf3 activating transcription factor 3 decreases expression ISO Phlorhizin results in decreased expression of ATF3 mRNA CTD PMID:16123366 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 increases expression ISO Phlorhizin results in increased expression of ATP2A2 mRNA CTD PMID:16123366 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326
JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha decreases expression ISO Phlorhizin results in decreased expression of ATP5A1 mRNA CTD PMID:22538082 NCBI chr18:74,156,553...74,164,490
Ensembl chr18:74,156,553...74,164,495
JBrowse link
G Atp5f1c ATP synthase F1 subunit gamma increases expression ISO Phlorhizin results in increased expression of ATP5C1 mRNA CTD PMID:22538082 NCBI chr17:72,209,321...72,231,562
Ensembl chr17:72,209,373...72,394,271
JBrowse link
G Auh AU RNA binding methylglutaconyl-CoA hydratase decreases expression ISO Phlorhizin results in decreased expression of AUH mRNA CTD PMID:22538082 NCBI chr17:12,310,178...12,405,224
Ensembl chr17:12,310,214...12,405,205
JBrowse link
G B2m beta-2 microglobulin increases expression ISO Phlorhizin results in increased expression of B2M mRNA CTD PMID:22538082 NCBI chr 3:114,087,287...114,093,311
Ensembl chr 3:114,087,287...114,093,309
JBrowse link
G Bag1 BAG cochaperone 1 decreases expression ISO Phlorhizin results in decreased expression of BAG1 mRNA CTD PMID:22538082 NCBI chr 5:57,254,421...57,267,002
Ensembl chr 5:57,254,421...57,267,002
JBrowse link
G Bckdhb branched chain keto acid dehydrogenase E1 subunit beta decreases expression ISO Phlorhizin results in decreased expression of BCKDHB mRNA CTD PMID:22538082 NCBI chr 8:91,464,229...91,656,134
Ensembl chr 8:91,464,229...91,656,134
JBrowse link
G Birc6 baculoviral IAP repeat-containing 6 increases expression ISO Phlorhizin results in increased expression of BIRC6 mRNA CTD PMID:22538082 NCBI chr 6:21,900,763...22,092,484
Ensembl chr 6:21,950,100...22,092,346
JBrowse link
G Cat catalase increases expression ISO Phlorhizin results in increased expression of CAT mRNA CTD PMID:22538082 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cct7 chaperonin containing TCP1 subunit 7 decreases expression ISO Phlorhizin results in decreased expression of CCT7 mRNA CTD PMID:22538082 NCBI chr 4:117,235,023...117,252,265
Ensembl chr 4:117,235,023...117,252,265
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions EXP Phlorhizin inhibits the reaction [Streptozocin results in increased expression of CHRM2 mRNA]; Phlorhizin inhibits the reaction [Streptozocin results in increased expression of CHRM2 protein] CTD PMID:18715473 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090
JBrowse link
G Clybl citramalyl-CoA lyase decreases expression ISO Phlorhizin results in decreased expression of CLYBL mRNA CTD PMID:22538082 NCBI chr15:108,608,203...108,838,222
Ensembl chr15:108,608,204...108,838,235
JBrowse link
G Cox15 cytochrome c oxidase assembly homolog COX15 decreases expression ISO Phlorhizin results in decreased expression of COX15 mRNA CTD PMID:22538082 NCBI chr 1:263,494,850...263,511,510
Ensembl chr 1:263,494,852...263,511,505
JBrowse link
G Cox17 cytochrome c oxidase copper chaperone COX17 decreases expression ISO Phlorhizin results in decreased expression of COX17 mRNA CTD PMID:22538082 NCBI chr11:64,962,663...64,968,437
Ensembl chr11:64,962,666...64,968,437
JBrowse link
G Cox7c cytochrome c oxidase subunit 7C increases expression ISO Phlorhizin results in increased expression of COX7C mRNA CTD PMID:22538082 NCBI chr 2:14,699,878...14,701,903
Ensembl chr 2:14,699,882...14,701,903
JBrowse link
G Cox8a cytochrome c oxidase subunit 8A decreases expression ISO Phlorhizin results in decreased expression of COX8A mRNA CTD PMID:22538082 NCBI chr 1:222,466,575...222,468,896
Ensembl chr 1:222,466,575...222,468,896
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression ISO Phlorhizin results in decreased expression of CPT1A mRNA CTD PMID:16123366, PMID:22538082 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 decreases expression ISO Phlorhizin results in decreased expression of CPT2 mRNA CTD PMID:22538082 NCBI chr 5:127,505,646...127,523,016
Ensembl chr 5:127,505,614...127,523,089
JBrowse link
G Crebbp CREB binding protein decreases expression ISO Phlorhizin results in decreased expression of CREBBP mRNA CTD PMID:22538082 NCBI chr10:11,590,994...11,721,039
Ensembl chr10:11,595,044...11,721,039
JBrowse link
G Cs citrate synthase decreases expression ISO Phlorhizin results in decreased expression of CS mRNA CTD PMID:22538082 NCBI chr 7:2,752,680...2,778,963
Ensembl chr 7:2,752,680...2,778,963
JBrowse link
G Cul1 cullin 1 decreases expression ISO Phlorhizin results in decreased expression of CUL1 mRNA CTD PMID:22538082 NCBI chr 4:77,211,814...77,283,369
Ensembl chr 4:77,211,692...77,280,250
JBrowse link
G Cyb5r3 cytochrome b5 reductase 3 decreases expression ISO Phlorhizin results in decreased expression of CYB5R3 mRNA CTD PMID:22538082 NCBI chr 7:124,024,003...124,041,564
Ensembl chr 7:124,023,995...124,041,594
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases expression ISO Phlorhizin results in decreased expression of CYP1A2 mRNA CTD PMID:22538082 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases expression ISO Phlorhizin results in decreased expression of CYP2B6 mRNA CTD PMID:22538082 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases expression ISO Phlorhizin results in increased expression of CYP2D6 mRNA CTD PMID:22538082 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 decreases expression ISO Phlorhizin results in decreased expression of CYP4F12 mRNA CTD PMID:22538082 NCBI chr 7:15,179,472...15,191,113
Ensembl chr 7:15,179,467...15,190,796
JBrowse link
G Dhrs4 dehydrogenase/reductase 4 decreases expression ISO Phlorhizin results in decreased expression of DHRS4 mRNA CTD PMID:22538082 NCBI chr15:34,155,043...34,167,073
Ensembl chr15:34,155,504...34,167,072
JBrowse link
G Dld dihydrolipoamide dehydrogenase decreases expression ISO Phlorhizin results in decreased expression of DLD mRNA CTD PMID:22538082 NCBI chr 6:50,597,677...50,618,694
Ensembl chr 6:50,597,677...50,618,694
JBrowse link
G Dnaja2 DnaJ heat shock protein family (Hsp40) member A2 decreases expression ISO Phlorhizin results in decreased expression of DNAJA2 mRNA CTD PMID:22538082 NCBI chr19:22,569,999...22,588,143
Ensembl chr19:22,569,999...22,588,137
JBrowse link
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 decreases expression ISO Phlorhizin results in decreased expression of DNAJA3 mRNA CTD PMID:22538082 NCBI chr10:11,059,701...11,085,186
Ensembl chr10:11,060,313...11,085,210
JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 decreases expression
increases expression
ISO Phlorhizin results in decreased expression of DNAJB1 mRNA
Phlorhizin results in increased expression of DNAJB1 mRNA
CTD PMID:22538082 NCBI chr19:24,747,178...24,750,919
Ensembl chr19:24,747,178...24,750,919
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 decreases expression ISO Phlorhizin results in decreased expression of DNAJB4 mRNA CTD PMID:22538082 NCBI chr 2:257,394,692...257,425,344
Ensembl chr 2:257,394,818...257,425,242
JBrowse link
G Dnajb6 DnaJ heat shock protein family (Hsp40) member B6 increases expression ISO Phlorhizin results in increased expression of DNAJB6 mRNA CTD PMID:22538082 NCBI chr 4:2,711,329...2,774,969
Ensembl chr 4:2,711,385...2,774,890
JBrowse link
G Dnajc1 DnaJ heat shock protein family (Hsp40) member C1 decreases expression ISO Phlorhizin results in decreased expression of DNAJC1 mRNA CTD PMID:22538082 NCBI chr17:84,986,994...85,141,464
Ensembl chr17:84,986,991...85,141,210
JBrowse link
G Dnajc13 DnaJ heat shock protein family (Hsp40) member C13 decreases expression ISO Phlorhizin results in decreased expression of DNAJC13 mRNA CTD PMID:22538082 NCBI chr 8:112,697,907...112,830,445
Ensembl chr 8:112,698,348...112,807,598
JBrowse link
G Dnajc14 DnaJ heat shock protein family (Hsp40) member C14 increases expression ISO Phlorhizin results in increased expression of DNAJC14 mRNA CTD PMID:22538082 NCBI chr 7:3,229,026...3,242,265
Ensembl chr 7:3,230,320...3,242,265
JBrowse link
G Dnajc19 DnaJ heat shock protein family (Hsp40) member C19 decreases expression ISO Phlorhizin results in decreased expression of DNAJC19 mRNA CTD PMID:22538082 NCBI chr 2:120,503,093...120,531,782
Ensembl chr 2:120,504,130...120,531,782
JBrowse link
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 decreases expression ISO Phlorhizin results in decreased expression of DNAJC3 mRNA CTD PMID:22538082 NCBI chr15:104,186,918...104,226,236
Ensembl chr15:104,186,792...104,226,329
JBrowse link
G Dnajc4 DnaJ heat shock protein family (Hsp40) member C4 increases expression ISO Phlorhizin results in increased expression of DNAJC4 mRNA CTD PMID:22538082 NCBI chr 1:222,242,889...222,247,115
Ensembl chr 1:222,242,858...222,246,768
JBrowse link
G Dnajc5 DnaJ heat shock protein family (Hsp40) member C5 decreases expression ISO Phlorhizin results in decreased expression of DNAJC5 mRNA CTD PMID:22538082 NCBI chr 3:177,012,714...177,047,787
Ensembl chr 3:177,013,604...177,043,902
JBrowse link
G Echs1 enoyl-CoA hydratase, short chain 1 decreases expression ISO Phlorhizin results in decreased expression of ECHS1 mRNA CTD PMID:22538082 NCBI chr 1:212,570,213...212,579,040
Ensembl chr 1:212,570,195...212,579,057
JBrowse link
G Ep300 E1A binding protein p300 decreases expression ISO Phlorhizin results in decreased expression of EP300 mRNA CTD PMID:22538082 NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296
JBrowse link
G Ephx1 epoxide hydrolase 1 decreases expression ISO Phlorhizin results in decreased expression of EPHX1 mRNA CTD PMID:22538082 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO Phlorhizin results in decreased expression of FAS mRNA CTD PMID:16123366 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fbxw7 F-box and WD repeat domain containing 7 decreases expression ISO Phlorhizin results in decreased expression of FBXW7 mRNA CTD PMID:22538082 NCBI chr 2:184,230,191...184,309,805
Ensembl chr 2:184,231,260...184,309,664
JBrowse link
G Fh fumarate hydratase decreases expression ISO Phlorhizin results in decreased expression of FH mRNA CTD PMID:22538082 NCBI chr13:93,651,486...93,677,371
Ensembl chr13:93,651,484...93,677,377
JBrowse link
G Fis1 fission, mitochondrial 1 increases expression ISO Phlorhizin results in increased expression of FIS1 mRNA CTD PMID:22538082 NCBI chr12:22,750,485...22,765,324
Ensembl chr12:22,750,485...22,765,308
JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 decreases expression ISO Phlorhizin results in decreased expression of FKBP5 mRNA CTD PMID:22538082 NCBI chr20:7,976,704...8,097,290
Ensembl chr20:7,976,713...8,019,020
JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 decreases expression ISO Phlorhizin results in decreased expression of FMO1 mRNA CTD PMID:22538082 NCBI chr13:80,712,885...80,745,095
Ensembl chr13:80,712,882...80,745,347
JBrowse link
G G6pc glucose-6-phosphatase, catalytic subunit multiple interactions EXP Phlorhizin inhibits the reaction [Streptozocin results in increased expression of G6PC mRNA] CTD PMID:12446591 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit decreases expression ISO Phlorhizin results in decreased expression of GCLC mRNA CTD PMID:22538082 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit decreases expression ISO Phlorhizin results in decreased expression of GCLM mRNA CTD PMID:22538082 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Glrx2 glutaredoxin 2 decreases expression ISO Phlorhizin results in decreased expression of GLRX2 mRNA CTD PMID:22538082 NCBI chr13:60,529,057...60,552,115
Ensembl chr13:60,529,932...60,537,916
JBrowse link
G Gpd2 glycerol-3-phosphate dehydrogenase 2 increases expression
decreases expression
ISO Phlorhizin results in increased expression of GPD2 mRNA
Phlorhizin results in decreased expression of GPD2 mRNA
CTD PMID:16123366, PMID:22538082 NCBI chr 3:43,223,892...43,359,069
Ensembl chr 3:43,255,567...43,359,074
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression ISO Phlorhizin results in decreased expression of GPX1 mRNA CTD PMID:16123366 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gpx7 glutathione peroxidase 7 increases expression ISO Phlorhizin results in increased expression of GPX7 mRNA CTD PMID:22538082 NCBI chr 5:128,001,766...128,009,610
Ensembl chr 5:128,001,761...128,009,735
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 decreases expression ISO Phlorhizin results in decreased expression of GSTA5 mRNA CTD PMID:22538082 NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179
JBrowse link
G Gstk1 glutathione S-transferase kappa 1 decreases expression ISO Phlorhizin results in decreased expression of GSTK1 mRNA CTD PMID:22538082 NCBI chr 4:71,621,777...71,626,096
Ensembl chr 4:71,621,729...71,626,107
JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases expression
increases expression
ISO Phlorhizin results in decreased expression of GSTM1 mRNA; Phlorhizin results in decreased expression of GSTM5 mRNA
Phlorhizin results in increased expression of GSTM5 mRNA
CTD PMID:22538082 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression ISO Phlorhizin results in increased expression of GSTM2 mRNA CTD PMID:22538082 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Gstm4 glutathione S-transferase mu 4 increases expression ISO Phlorhizin results in increased expression of GSTM4 mRNA CTD PMID:22538082 NCBI chr 2:210,834,013...210,839,242
Ensembl chr 2:210,833,884...210,839,295
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression ISO Phlorhizin results in increased expression of GSTP1 mRNA CTD PMID:22538082 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Gstt1 glutathione S-transferase theta 1 decreases expression
increases expression
ISO Phlorhizin results in decreased expression of GSTT1 mRNA
Phlorhizin results in increased expression of GSTT1 mRNA
CTD PMID:22538082 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
JBrowse link
G Gstt2 glutathione S-transferase, theta 2 decreases expression ISO Phlorhizin results in decreased expression of GSTT2B mRNA CTD PMID:22538082 NCBI chr20:13,760,810...13,764,481
Ensembl chr20:13,760,810...13,764,475
JBrowse link
G Hacd3 3-hydroxyacyl-CoA dehydratase 3 decreases expression ISO Phlorhizin results in decreased expression of HACD3 mRNA CTD PMID:22538082 NCBI chr 8:70,471,572...70,509,874
Ensembl chr 8:70,471,572...70,509,874
JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta increases expression ISO Phlorhizin results in increased expression of HADHB mRNA CTD PMID:22538082 NCBI chr 6:27,555,408...27,589,539
Ensembl chr 6:27,555,412...27,582,995
JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 decreases expression ISO Phlorhizin results in decreased expression of HERPUD1 mRNA CTD PMID:22538082 NCBI chr19:11,046,905...11,057,440
Ensembl chr19:11,046,909...11,057,254
JBrowse link
G Hibadh 3-hydroxyisobutyrate dehydrogenase decreases expression ISO Phlorhizin results in decreased expression of HIBADH mRNA CTD PMID:22538082 NCBI chr 4:82,604,369...82,702,429
Ensembl chr 4:82,604,373...82,702,429
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 decreases expression ISO Phlorhizin results in decreased expression of HMGCS1 mRNA CTD PMID:22538082 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
JBrowse link
G Hmox1 heme oxygenase 1 decreases expression ISO Phlorhizin results in decreased expression of HMOX1 mRNA CTD PMID:16123366 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hras HRas proto-oncogene, GTPase increases expression ISO Phlorhizin results in increased expression of HRAS mRNA CTD PMID:22538082 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 decreases expression ISO Phlorhizin results in decreased expression of HSD17B10 mRNA CTD PMID:22538082 NCBI chr  X:21,696,796...21,699,241
Ensembl chr  X:21,696,772...21,699,241
JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 decreases expression ISO Phlorhizin results in decreased expression of HSD17B4 mRNA CTD PMID:22538082 NCBI chr18:44,810,462...44,897,677
Ensembl chr18:44,810,388...44,897,640
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 decreases expression ISO Phlorhizin results in decreased expression of HSP90AA1 mRNA CTD PMID:22538082 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 decreases expression ISO Phlorhizin results in decreased expression of HSP90AB1 mRNA CTD PMID:22538082 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
G Hspa13 heat shock protein family A (Hsp70) member 13 decreases expression ISO Phlorhizin results in decreased expression of HSPA13 mRNA CTD PMID:22538082 NCBI chr11:14,146,515...14,160,697
Ensembl chr11:14,144,130...14,160,892
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Phlorhizin results in increased expression of HSPA5 mRNA CTD PMID:22538082 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression ISO Phlorhizin results in increased expression of HSPA8 mRNA CTD PMID:22538082 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 decreases expression ISO Phlorhizin results in decreased expression of HSPA9 mRNA CTD PMID:22538082 NCBI chr18:27,731,072...27,749,235
Ensembl chr18:27,731,072...27,749,235
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression ISO Phlorhizin results in increased expression of HSPB1 mRNA CTD PMID:22538082 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Hspb8 heat shock protein family B (small) member 8 decreases expression ISO Phlorhizin results in decreased expression of HSPB8 mRNA CTD PMID:22538082 NCBI chr12:45,905,371...45,920,014
Ensembl chr12:45,905,371...45,920,013
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 decreases expression ISO Phlorhizin results in decreased expression of HSPD1 mRNA CTD PMID:22538082 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 decreases expression ISO Phlorhizin results in decreased expression of HSPE1 mRNA CTD PMID:22538082 NCBI chr 9:61,691,246...61,724,948
Ensembl chr 9:61,692,154...61,694,599
JBrowse link
G Htra2 HtrA serine peptidase 2 decreases expression ISO Phlorhizin results in decreased expression of HTRA2 mRNA CTD PMID:22538082 NCBI chr 4:113,883,671...113,886,833
Ensembl chr 4:113,883,670...113,886,994
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein decreases expression ISO Phlorhizin results in decreased expression of ID1 mRNA CTD PMID:16123366 NCBI chr 3:148,214,623...148,216,715
Ensembl chr 3:148,215,540...148,216,718
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 increases expression ISO Phlorhizin results in increased expression of IDH2 mRNA CTD PMID:22538082 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705
JBrowse link
G Idh3a isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha decreases expression ISO Phlorhizin results in decreased expression of IDH3A mRNA CTD PMID:22538082 NCBI chr 8:59,164,601...59,183,899
Ensembl chr 8:59,164,572...59,183,908
JBrowse link
G Idh3b isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta decreases expression ISO Phlorhizin results in decreased expression of IDH3B mRNA CTD PMID:22538082 NCBI chr 3:122,808,564...122,813,638
Ensembl chr 3:122,808,564...122,813,583
JBrowse link
G Idh3g isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma decreases expression ISO Phlorhizin results in decreased expression of IDH3G mRNA CTD PMID:22538082 NCBI chr  X:156,999,803...157,008,735
Ensembl chr  X:156,999,826...157,008,733
JBrowse link
G Ivd isovaleryl-CoA dehydrogenase decreases expression ISO Phlorhizin results in decreased expression of IVD mRNA CTD PMID:22538082 NCBI chr 3:110,669,355...110,689,789
Ensembl chr 3:110,669,312...110,690,173
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Phlorhizin results in decreased expression of JUNB mRNA CTD PMID:22538082 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756
JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit increases expression ISO Phlorhizin results in increased expression of JUND mRNA CTD PMID:22538082 NCBI chr16:20,485,028...20,486,707
Ensembl chr16:20,485,029...20,486,707
JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 increases expression ISO Phlorhizin results in increased expression of KCNJ11 mRNA CTD PMID:16123366 NCBI chr 1:102,103,093...102,107,134
Ensembl chr 1:102,103,094...102,106,127
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 increases expression ISO Phlorhizin results in increased expression of KEAP1 mRNA CTD PMID:22538082 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Kras KRAS proto-oncogene, GTPase decreases expression ISO Phlorhizin results in decreased expression of KRAS mRNA CTD PMID:22538082 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
JBrowse link
G Maf MAF bZIP transcription factor decreases expression ISO Phlorhizin results in decreased expression of MAF mRNA CTD PMID:22538082 NCBI chr19:48,179,826...48,200,995
Ensembl chr19:48,194,804...48,196,748
JBrowse link
G Mafg MAF bZIP transcription factor G decreases expression ISO Phlorhizin results in decreased expression of MAFG mRNA CTD PMID:22538082 NCBI chr10:109,802,877...109,811,476
Ensembl chr10:109,806,159...109,811,323
JBrowse link
G Maob monoamine oxidase B decreases expression ISO Phlorhizin results in decreased expression of MAOB mRNA CTD PMID:22538082 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 increases expression ISO Phlorhizin results in increased expression of MAP2K2 mRNA CTD PMID:22538082 NCBI chr 7:11,458,971...11,478,520
Ensembl chr 7:11,458,967...11,478,489
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 increases expression ISO Phlorhizin results in increased expression of MAP2K6 mRNA CTD PMID:22538082 NCBI chr10:98,707,160...98,823,054
Ensembl chr10:98,706,960...98,823,287
JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 increases expression ISO Phlorhizin results in increased expression of MAP2K7 mRNA CTD PMID:22538082 NCBI chr12:2,546,278...2,555,310
Ensembl chr12:2,548,218...2,555,164
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 decreases expression ISO Phlorhizin results in decreased expression of MAP3K7 mRNA CTD PMID:22538082 NCBI chr 5:47,183,142...47,244,424
Ensembl chr 5:47,186,558...47,244,416
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases expression ISO Phlorhizin results in increased expression of MAPK3 mRNA CTD PMID:22538082 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 decreases expression ISO Phlorhizin results in decreased expression of MAPK9 mRNA CTD PMID:22538082 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mccc2 methylcrotonoyl-CoA carboxylase 2 decreases expression ISO Phlorhizin results in decreased expression of MCCC2 mRNA CTD PMID:22538082 NCBI chr 2:30,175,017...30,246,028
Ensembl chr 2:30,175,018...30,246,010
JBrowse link
G Mdm2 MDM2 proto-oncogene decreases expression ISO Phlorhizin results in decreased expression of MDM2 mRNA CTD PMID:22538082 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Med20 mediator complex subunit 20 decreases expression ISO Phlorhizin results in decreased expression of MED20 mRNA CTD PMID:22538082 NCBI chr 9:15,379,379...15,393,131
Ensembl chr 9:15,379,385...15,393,131
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 increases expression ISO Phlorhizin results in increased expression of MGST1 mRNA CTD PMID:22538082 NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607
JBrowse link
G Mmut methylmalonyl-CoA mutase decreases expression ISO Phlorhizin results in decreased expression of MMUT mRNA CTD PMID:22538082 NCBI chr 9:23,323,934...23,352,144
Ensembl chr 9:23,323,936...23,352,668
JBrowse link
G Myl9 myosin light chain 9 decreases phosphorylation EXP Phlorhizin results in decreased phosphorylation of MYL9 protein CTD PMID:17272349 NCBI chr 3:152,857,573...152,863,961
Ensembl chr 3:152,857,592...152,863,960
JBrowse link
G Ndufa12 NADH:ubiquinone oxidoreductase subunit A12 increases expression ISO Phlorhizin results in increased expression of NDUFA12 mRNA CTD PMID:22538082 NCBI chr 7:35,125,516...35,163,182
Ensembl chr 7:35,125,424...35,167,406
JBrowse link
G Ndufa2 NADH:ubiquinone oxidoreductase subunit A2 increases expression ISO Phlorhizin results in increased expression of NDUFA2 mRNA CTD PMID:22538082 NCBI chr18:29,585,671...29,587,760
Ensembl chr18:29,585,671...29,587,760
JBrowse link
G Ndufa3 NADH:ubiquinone oxidoreductase subunit A3 decreases expression ISO Phlorhizin results in decreased expression of NDUFA3 mRNA CTD PMID:22538082 NCBI chr 1:64,172,462...64,175,174
Ensembl chr 1:64,172,540...64,175,099
JBrowse link
G Ndufa7 NADH:ubiquinone oxidoreductase subunit A7 increases expression ISO Phlorhizin results in increased expression of NDUFA7 mRNA CTD PMID:22538082 NCBI chr 7:18,683,553...18,696,332
Ensembl chr 7:18,683,553...18,696,330
JBrowse link
G Ndufab1 NADH:ubiquinone oxidoreductase subunit AB1 increases expression ISO Phlorhizin results in increased expression of NDUFAB1 mRNA CTD PMID:22538082 NCBI chr 1:192,044,209...192,057,644
Ensembl chr 1:192,044,216...192,057,612
JBrowse link
G Ndufaf1 NADH:ubiquinone oxidoreductase complex assembly factor 1 decreases expression ISO Phlorhizin results in decreased expression of NDUFAF1 mRNA CTD PMID:22538082 NCBI chr 3:111,458,227...111,469,239
Ensembl chr 3:111,458,572...111,469,518
JBrowse link
G Ndufb6 NADH:ubiquinone oxidoreductase subunit B6 decreases expression ISO Phlorhizin results in decreased expression of NDUFB6 mRNA CTD PMID:22538082 NCBI chr 5:56,567,109...56,576,676
Ensembl chr 5:56,567,109...56,576,676
JBrowse link
G Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 decreases expression ISO Phlorhizin results in decreased expression of NDUFS1 mRNA CTD PMID:22538082 NCBI chr 9:69,919,863...69,953,182
Ensembl chr 9:69,919,867...69,953,182
JBrowse link
G Ndufs4 NADH:ubiquinone oxidoreductase subunit S4 decreases expression ISO Phlorhizin results in decreased expression of NDUFS4 mRNA CTD PMID:22538082 NCBI chr 2:46,372,488...46,476,162
Ensembl chr 2:46,372,518...46,476,203
JBrowse link
G Ndufs5 NADH:ubiquinone oxidoreductase subunit S5 decreases expression ISO Phlorhizin results in decreased expression of NDUFS5 mRNA CTD PMID:22538082 NCBI chr 5:141,390,577...141,405,507
Ensembl chr 5:141,390,580...141,405,453
JBrowse link
G Ndufs8 NADH:ubiquinone oxidoreductase core subunit S8 increases expression ISO Phlorhizin results in increased expression of NDUFS8 mRNA CTD PMID:22538082 NCBI chr 1:219,141,289...219,144,610
Ensembl chr 1:219,141,292...219,144,610
JBrowse link
G Nedd4 NEDD4 E3 ubiquitin protein ligase decreases expression ISO Phlorhizin results in decreased expression of NEDD4 mRNA CTD PMID:22538082 NCBI chr 8:79,323,408...79,408,842
Ensembl chr 8:79,323,408...79,408,833
JBrowse link
G Neurod1 neuronal differentiation 1 increases expression ISO Phlorhizin results in increased expression of NEUROD1 mRNA CTD PMID:16123366 NCBI chr 3:66,414,314...66,417,617
Ensembl chr 3:66,414,308...66,417,741
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 decreases expression ISO Phlorhizin results in decreased expression of NFE2L2 mRNA CTD PMID:22538082 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nkx6-1 NK6 homeobox 1 increases expression ISO Phlorhizin results in increased expression of NKX6-1 mRNA CTD PMID:16123366 NCBI chr14:9,555,264...9,562,197
Ensembl chr14:9,555,264...9,562,189
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
decreases expression
ISO Phlorhizin inhibits the reaction [Hydrogen Peroxide results in increased expression of NOS3 mRNA]
Phlorhizin results in decreased expression of NOS3 mRNA
CTD PMID:20021702 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nras NRAS proto-oncogene, GTPase decreases expression ISO Phlorhizin results in decreased expression of NRAS mRNA CTD PMID:22538082 NCBI chr 2:205,553,119...205,563,716
Ensembl chr 2:205,553,163...205,560,791
JBrowse link
G Ogdh oxoglutarate dehydrogenase decreases expression ISO Phlorhizin results in decreased expression of OGDH mRNA CTD PMID:22538082 NCBI chr14:86,414,924...86,481,903
Ensembl chr14:86,414,949...86,613,327
JBrowse link
G Park7 Parkinsonism associated deglycase increases expression ISO Phlorhizin results in increased expression of PARK7 mRNA CTD PMID:22538082 NCBI chr 5:167,982,438...168,004,724
Ensembl chr 5:167,982,439...168,004,724
JBrowse link
G Pc pyruvate carboxylase increases expression
decreases expression
ISO Phlorhizin results in increased expression of PCX mRNA
Phlorhizin results in decreased expression of PC mRNA
CTD PMID:16123366, PMID:22538082 NCBI chr 1:219,759,157...219,859,854
Ensembl chr 1:219,759,183...219,859,848
JBrowse link
G Pcca propionyl-CoA carboxylase subunit alpha decreases expression ISO Phlorhizin results in decreased expression of PCCA mRNA CTD PMID:22538082 NCBI chr15:108,960,509...109,306,879
Ensembl chr15:108,960,562...109,306,603
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 decreases expression ISO Phlorhizin results in decreased expression of PCK1 mRNA CTD PMID:22538082 NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871
JBrowse link
G Pecr peroxisomal trans-2-enoyl-CoA reductase increases expression
decreases expression
ISO Phlorhizin results in increased expression of PECR mRNA
Phlorhizin results in decreased expression of PECR mRNA
CTD PMID:22538082 NCBI chr 9:79,601,937...79,630,547
Ensembl chr 9:79,601,901...79,630,536
JBrowse link
G Pik3c2a phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha decreases expression ISO Phlorhizin results in decreased expression of PIK3C2A mRNA CTD PMID:22538082 NCBI chr 1:185,210,922...185,326,314
Ensembl chr 1:185,210,922...185,326,314
JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 decreases expression ISO Phlorhizin results in decreased expression of PIK3C3 mRNA CTD PMID:22538082 NCBI chr18:22,964,121...23,047,896
Ensembl chr18:22,964,210...23,047,895
JBrowse link
G Pink1 PTEN induced kinase 1 increases expression ISO Phlorhizin results in increased expression of PINK1 mRNA CTD PMID:22538082 NCBI chr 5:156,677,146...156,689,258
Ensembl chr 5:156,677,146...156,689,415
JBrowse link
G Prdx1 peroxiredoxin 1 increases expression ISO Phlorhizin results in increased expression of PRDX1 mRNA CTD PMID:22538082 NCBI chr 5:135,536,413...135,551,986
Ensembl chr 5:135,536,413...135,551,990
JBrowse link
G Prdx5 peroxiredoxin 5 decreases expression ISO Phlorhizin results in decreased expression of PRDX5 mRNA CTD PMID:22538082 NCBI chr 1:222,164,462...222,167,447
Ensembl chr 1:222,164,462...222,167,447
JBrowse link
G Prkch protein kinase C, eta increases expression ISO Phlorhizin results in increased expression of PRKCH mRNA CTD PMID:22538082 NCBI chr 6:96,479,243...96,677,368
Ensembl chr 6:96,479,430...96,676,225
JBrowse link
G Prkci protein kinase C, iota decreases expression ISO Phlorhizin results in decreased expression of PRKCI mRNA CTD PMID:22538082 NCBI chr 2:115,941,998...116,002,550
Ensembl chr 2:115,941,993...116,002,561
JBrowse link
G Prkd3 protein kinase D3 decreases expression ISO Phlorhizin results in decreased expression of PRKD3 mRNA CTD PMID:22538082 NCBI chr 6:1,546,018...1,622,232
Ensembl chr 6:1,548,415...1,622,196
JBrowse link
G Psma4 proteasome 20S subunit alpha 4 decreases expression ISO Phlorhizin results in decreased expression of PSMA4 mRNA CTD PMID:22538082 NCBI chr 8:59,532,456...59,539,916
Ensembl chr 8:59,532,389...59,539,920
JBrowse link
G Psmb1 proteasome 20S subunit beta 1 increases expression ISO Phlorhizin results in increased expression of PSMB1 mRNA CTD PMID:22538082 NCBI chr 1:57,470,878...57,491,359
Ensembl chr 1:57,470,632...57,489,727
JBrowse link
G Psmb2 proteasome 20S subunit beta 2 decreases expression ISO Phlorhizin results in decreased expression of PSMB2 mRNA CTD PMID:22538082 NCBI chr 5:144,702,004...144,734,220
Ensembl chr 5:144,701,949...144,734,257
JBrowse link
G Psmc1 proteasome 26S subunit, ATPase 1 decreases expression ISO Phlorhizin results in decreased expression of PSMC1 mRNA CTD PMID:22538082 NCBI chr 6:124,123,283...124,135,644
Ensembl chr 6:124,123,228...124,135,658
JBrowse link
G Psmc4 proteasome 26S subunit, ATPase 4 increases expression
decreases expression
ISO Phlorhizin results in increased expression of PSMC4 mRNA
Phlorhizin results in decreased expression of PSMC4 mRNA
CTD PMID:22538082 NCBI chr 1:84,978,220...84,986,536
Ensembl chr 1:84,978,206...84,986,581
JBrowse link
G Psmc6 proteasome 26S subunit, ATPase 6 decreases expression ISO Phlorhizin results in decreased expression of PSMC6 mRNA CTD PMID:22538082 NCBI chr15:19,667,453...19,688,916
Ensembl chr15:19,667,453...19,688,914
JBrowse link
G Psmd10 proteasome 26S subunit, non-ATPase 10 decreases expression ISO Phlorhizin results in decreased expression of PSMD10 mRNA CTD PMID:22538082 NCBI chr  X:112,323,188...112,328,642
Ensembl chr  X:112,323,187...112,328,642
JBrowse link
G Psmd12 proteasome 26S subunit, non-ATPase 12 decreases expression ISO Phlorhizin results in decreased expression of PSMD12 mRNA CTD PMID:22538082 NCBI chr10:95,706,808...95,725,452
Ensembl chr10:95,706,685...95,725,812
JBrowse link
G Psmd14 proteasome 26S subunit, non-ATPase 14 decreases expression ISO Phlorhizin results in decreased expression of PSMD14 mRNA CTD PMID:22538082 NCBI chr 3:47,578,449...47,673,330
Ensembl chr 3:47,578,384...47,673,338
JBrowse link
G Psmd4 proteasome 26S subunit, non-ATPase 4 decreases expression ISO Phlorhizin results in decreased expression of PSMD4 mRNA CTD PMID:22538082 NCBI chr 2:196,198,303...196,207,569
Ensembl chr 2:196,198,038...196,207,560
JBrowse link
G Psmd6 proteasome 26S subunit, non-ATPase 6 increases expression ISO Phlorhizin results in increased expression of PSMD6 mRNA CTD PMID:22538082 NCBI chr15:12,407,557...12,416,153
Ensembl chr15:12,407,524...12,416,105
JBrowse link
G Psmd7 proteasome 26S subunit, non-ATPase 7 decreases expression ISO Phlorhizin results in decreased expression of PSMD7 mRNA CTD PMID:22538082 NCBI chr19:39,639,432...39,646,718
Ensembl chr19:39,639,431...39,646,693
JBrowse link
G Psmd9 proteasome 26S subunit, non-ATPase 9 decreases expression ISO Phlorhizin results in decreased expression of PSMD9 mRNA CTD PMID:22538082 NCBI chr12:38,786,539...38,805,121
Ensembl chr12:38,786,540...38,805,121
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases expression ISO Phlorhizin results in decreased expression of RAF1 mRNA CTD PMID:22538082 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Rdh14 retinol dehydrogenase 14 increases expression ISO Phlorhizin results in increased expression of RDH14 mRNA CTD PMID:22538082 NCBI chr 6:36,106,926...36,112,069
Ensembl chr 6:36,107,147...36,112,064
JBrowse link
G S100a6 S100 calcium binding protein A6 decreases expression ISO Phlorhizin results in decreased expression of S100A6 mRNA CTD PMID:16123366 NCBI chr 2:190,007,013...190,008,512
Ensembl chr 2:190,007,216...190,008,511
JBrowse link
G Sdha succinate dehydrogenase complex flavoprotein subunit A decreases expression ISO Phlorhizin results in decreased expression of SDHA mRNA CTD PMID:22538082 NCBI chr 1:31,545,631...31,570,601
Ensembl chr 1:31,545,631...31,570,601
JBrowse link
G Sdhb succinate dehydrogenase complex iron sulfur subunit B increases expression ISO Phlorhizin results in increased expression of SDHB mRNA CTD PMID:22538082 NCBI chr 5:159,484,378...159,505,063
Ensembl chr 5:159,484,370...159,505,064
JBrowse link
G Sds serine dehydratase decreases expression ISO Phlorhizin results in decreased expression of SDS mRNA CTD PMID:22538082 NCBI chr12:41,620,429...41,627,741
Ensembl chr12:41,620,393...41,627,741
JBrowse link
G Slc2a2 solute carrier family 2 member 2 increases expression ISO Phlorhizin results in increased expression of SLC2A2 mRNA CTD PMID:16123366 NCBI chr 2:114,413,427...114,445,418
Ensembl chr 2:114,413,410...114,445,395
JBrowse link
G Slc35a2 solute carrier family 35 member A2 increases expression ISO Phlorhizin results in increased expression of SLC35A2 mRNA CTD PMID:22538082 NCBI chr  X:15,453,184...15,461,990
Ensembl chr  X:15,453,186...15,461,713
JBrowse link
G Slc5a1 solute carrier family 5 member 1 multiple interactions
decreases activity
affects binding
ISO
EXP
Phlorhizin inhibits the reaction [[Sodium co-treated with SLC5A1 protein] results in increased uptake of methylglucoside]; Phlorhizin inhibits the reaction [SLC5A1 protein results in increased uptake of methylglucoside]
[Phlorhizin results in decreased activity of SLC5A1 protein] which results in decreased uptake of spiraeoside
[Phlorhizin results in decreased activity of SLC5A1 protein] which results in decreased uptake of Glucose
SLC5A1 protein binds to Phlorhizin
CTD PMID:12663055, PMID:12927799, PMID:16300400, PMID:17288452, PMID:17983207 NCBI chr14:82,910,448...82,975,303
Ensembl chr14:82,909,981...82,975,263
JBrowse link
G Slc5a2 solute carrier family 5 member 2 decreases activity ISO Phlorhizin results in decreased activity of SLC5A2 protein CTD PMID:21128592 NCBI chr 1:199,682,688...199,688,809
Ensembl chr 1:199,682,688...199,688,809
JBrowse link
G Sod1 superoxide dismutase 1 increases expression ISO Phlorhizin results in increased expression of SOD1 mRNA CTD PMID:22538082 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 decreases expression ISO Phlorhizin results in decreased expression of SOD2 mRNA CTD PMID:22538082 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Stip1 stress-induced phosphoprotein 1 decreases expression ISO Phlorhizin results in decreased expression of STIP1 mRNA CTD PMID:22538082 NCBI chr 1:222,274,133...222,293,139
Ensembl chr 1:222,274,133...222,293,148
JBrowse link
G Sucla2 succinate-CoA ligase ADP-forming subunit beta decreases expression ISO Phlorhizin results in decreased expression of SUCLA2 mRNA CTD PMID:22538082 NCBI chr15:55,461,695...55,516,954
Ensembl chr15:55,461,695...55,516,952
JBrowse link
G Suclg2 succinate-CoA ligase GDP-forming subunit beta decreases expression ISO Phlorhizin results in decreased expression of SUCLG2 mRNA CTD PMID:22538082 NCBI chr 4:127,552,100...127,824,970
Ensembl chr 4:127,552,101...127,824,970
JBrowse link
G Sugt1 SGT1 homolog, MIS12 kinetochore complex assembly cochaperone decreases expression ISO Phlorhizin results in decreased expression of SUGT1 mRNA CTD PMID:22538082 NCBI chr15:61,873,158...61,913,983
Ensembl chr15:61,873,056...61,914,072
JBrowse link
G Txn1 thioredoxin 1 decreases expression
increases expression
ISO Phlorhizin results in decreased expression of TXN mRNA
Phlorhizin results in increased expression of TXN mRNA
CTD PMID:22538082 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Txn2 thioredoxin 2 increases expression ISO Phlorhizin results in increased expression of TXN2 mRNA CTD PMID:22538082 NCBI chr 7:119,144,350...119,158,173
Ensembl chr 7:119,144,351...119,158,201
JBrowse link
G Ubb ubiquitin B increases expression ISO Phlorhizin results in increased expression of UBB mRNA CTD PMID:22538082 NCBI chr10:48,880,231...48,881,896
Ensembl chr10:48,881,049...48,881,881
JBrowse link
G Ubc ubiquitin C decreases expression ISO Phlorhizin results in decreased expression of UBC mRNA CTD PMID:22538082 NCBI chr12:36,638,457...36,642,734
Ensembl chr12:36,638,457...36,642,734
JBrowse link
G Ube2b ubiquitin-conjugating enzyme E2B decreases expression ISO Phlorhizin results in decreased expression of UBE2B mRNA CTD PMID:22538082 NCBI chr10:37,439,947...37,454,867
Ensembl chr10:37,441,284...37,455,022
JBrowse link
G Ube2f ubiquitin-conjugating enzyme E2F (putative) decreases expression ISO Phlorhizin results in decreased expression of UBE2F mRNA CTD PMID:22538082 NCBI chr 9:98,394,112...98,428,684
Ensembl chr 9:98,398,128...98,428,128
JBrowse link
G Ube2h ubiquitin-conjugating enzyme E2H decreases expression ISO Phlorhizin results in decreased expression of UBE2H mRNA CTD PMID:22538082 NCBI chr 4:57,511,418...57,625,147
Ensembl chr 4:57,511,418...57,625,257
JBrowse link
G Ube2i ubiquitin-conjugating enzyme E2I decreases expression ISO Phlorhizin results in decreased expression of UBE2I mRNA CTD PMID:22538082 NCBI chr10:14,618,615...14,639,274
Ensembl chr10:14,620,531...14,630,151
JBrowse link
G Ube2l3 ubiquitin-conjugating enzyme E2L 3 decreases expression ISO Phlorhizin results in decreased expression of UBE2L3 mRNA CTD PMID:22538082 NCBI chr11:88,047,186...88,088,477
Ensembl chr11:88,047,832...88,088,476
JBrowse link
G Ube2m ubiquitin-conjugating enzyme E2M increases expression ISO Phlorhizin results in increased expression of UBE2M mRNA CTD PMID:22538082 NCBI chr 1:65,537,640...65,541,177
Ensembl chr 1:65,537,640...65,541,177
JBrowse link
G Ube2n ubiquitin-conjugating enzyme E2N decreases expression ISO Phlorhizin results in decreased expression of UBE2N mRNA CTD PMID:22538082 NCBI chr 7:36,610,147...36,640,190
Ensembl chr 7:36,610,147...36,640,189
JBrowse link
G Ube2q1 ubiquitin conjugating enzyme E2 Q1 increases expression ISO Phlorhizin results in increased expression of UBE2Q1 mRNA CTD PMID:22538082 NCBI chr 2:189,106,039...189,115,110
Ensembl chr 2:189,106,039...189,115,108
JBrowse link
G Ube2r2 ubiquitin-conjugating enzyme E2R 2 decreases expression ISO Phlorhizin results in decreased expression of UBE2R2 mRNA CTD PMID:22538082 NCBI chr 5:57,472,315...57,530,973
Ensembl chr 5:57,472,315...57,530,987
JBrowse link
G Ube2v2 ubiquitin conjugating enzyme E2 V2 decreases expression ISO Phlorhizin results in decreased expression of UBE2V2 mRNA CTD PMID:22538082 NCBI chr11:89,557,273...89,591,175
Ensembl chr11:89,557,273...89,591,175
JBrowse link
G Ube4a ubiquitination factor E4A increases expression ISO Phlorhizin results in increased expression of UBE4A mRNA CTD PMID:22538082 NCBI chr 8:49,229,713...49,271,894
Ensembl chr 8:49,229,717...49,271,834
JBrowse link
G Ubr2 ubiquitin protein ligase E3 component n-recognin 2 increases expression ISO Phlorhizin results in increased expression of UBR2 mRNA CTD PMID:22538082 NCBI chr 9:16,003,058...16,080,152
Ensembl chr 9:16,003,058...16,080,152
JBrowse link
G Uchl3 ubiquitin C-terminal hydrolase L3 decreases expression ISO Phlorhizin results in decreased expression of UCHL3 mRNA CTD PMID:22538082 NCBI chr15:86,153,624...86,198,127
Ensembl chr15:86,153,628...86,198,127
JBrowse link
G Uchl5 ubiquitin C-terminal hydrolase L5 decreases expression ISO Phlorhizin results in decreased expression of UCHL5 mRNA CTD PMID:22538082 NCBI chr13:60,568,102...60,603,812
Ensembl chr13:60,545,635...60,603,811
JBrowse link
G Uqcrc2 ubiquinol cytochrome c reductase core protein 2 decreases expression ISO Phlorhizin results in decreased expression of UQCRC2 mRNA CTD PMID:22538082 NCBI chr 1:190,555,177...190,585,741
Ensembl chr 1:190,555,177...190,585,734
JBrowse link
G Usp1 ubiquitin specific peptidase 1 increases expression ISO Phlorhizin results in increased expression of USP1 mRNA CTD PMID:22538082 NCBI chr 5:117,583,502...117,594,872
Ensembl chr 5:117,583,502...117,594,870
JBrowse link
G Usp14 ubiquitin specific peptidase 14 decreases expression ISO Phlorhizin results in decreased expression of USP14 mRNA CTD PMID:22538082 NCBI chr18:1,178,785...1,216,573
Ensembl chr18:1,178,787...1,216,409
JBrowse link
G Usp19 ubiquitin specific peptidase 19 increases expression ISO Phlorhizin results in increased expression of USP19 mRNA CTD PMID:22538082 NCBI chr 8:117,280,690...117,291,729
Ensembl chr 8:117,280,705...117,291,351
JBrowse link
G Usp24 ubiquitin specific peptidase 24 decreases expression ISO Phlorhizin results in decreased expression of USP24 mRNA CTD PMID:22538082 NCBI chr 5:125,896,725...126,030,411
Ensembl chr 5:125,896,725...126,030,401
JBrowse link
G Usp33 ubiquitin specific peptidase 33 decreases expression ISO Phlorhizin results in decreased expression of USP33 mRNA CTD PMID:22538082 NCBI chr 2:257,567,179...257,602,817
Ensembl chr 2:257,568,613...257,602,810
JBrowse link
G Usp4 ubiquitin specific peptidase 4 increases expression ISO Phlorhizin results in increased expression of USP4 mRNA CTD PMID:22538082 NCBI chr 8:117,126,692...117,171,012
Ensembl chr 8:117,126,692...117,171,012
JBrowse link
G Usp45 ubiquitin specific peptidase 45 decreases expression ISO Phlorhizin results in decreased expression of USP45 mRNA CTD PMID:22538082 NCBI chr 5:35,916,763...35,984,525
Ensembl chr 5:35,916,804...35,984,524
JBrowse link
G Usp46 ubiquitin specific peptidase 46 decreases expression ISO Phlorhizin results in decreased expression of USP46 mRNA CTD PMID:22538082 NCBI chr14:36,687,134...36,755,360
Ensembl chr14:36,687,134...36,755,360
JBrowse link
G Usp7 ubiquitin specific peptidase 7 decreases expression ISO Phlorhizin results in decreased expression of USP7 mRNA CTD PMID:22538082 NCBI chr10:6,930,462...7,019,910
Ensembl chr10:6,975,244...7,018,930
JBrowse link
G Usp9x ubiquitin specific peptidase 9, X-linked decreases expression ISO Phlorhizin results in decreased expression of USP9X mRNA CTD PMID:22538082 NCBI chr  X:10,510,033...10,660,555
Ensembl chr  X:10,510,033...10,630,297
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO Phlorhizin results in decreased expression of XIAP mRNA CTD PMID:22538082 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link
trilobatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide affects the localization of BAX protein] CTD PMID:30104959 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein] CTD PMID:30104959 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Cat catalase multiple interactions ISO NFE2L2 protein affects the reaction [trilobatin inhibits the reaction [Isoflurane results in decreased activity of CAT protein]]; trilobatin inhibits the reaction [Isoflurane results in decreased activity of CAT protein] CTD PMID:32663520 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of ESRRA protein] CTD PMID:30104959 NCBI chr 1:222,168,729...222,178,842
Ensembl chr 1:222,168,730...222,178,725
JBrowse link
G Foxo3 forkhead box O3 multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of FOXO3 protein] CTD PMID:30104959 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of GPX1 protein] CTD PMID:30104959 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO
EXP
trilobatin promotes the reaction [Isoflurane results in increased expression of HMOX1 mRNA]; trilobatin promotes the reaction [Isoflurane results in increased expression of HMOX1 protein]
trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of HMOX1 protein]
CTD PMID:30104959, PMID:32663520 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased activity of IDH2 protein]; trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of IDH2 protein] CTD PMID:30104959 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO trilobatin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; trilobatin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] CTD PMID:25053100 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO trilobatin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; trilobatin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; trilobatin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:25053100 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide results in increased expression of KEAP1 protein] CTD PMID:30104959 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Mt-atp6 mitochondrially encoded ATP synthase membrane subunit 6 multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of ATP6 mRNA] CTD PMID:30104959 NCBI chr MT:7,919...8,599
Ensembl chr MT:7,919...8,599
JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of COX1 mRNA] CTD PMID:30104959 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
JBrowse link
G Mt-cyb mitochondrially encoded cytochrome b multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of CYTB mRNA] CTD PMID:30104959 NCBI chr MT:14,136...15,278
Ensembl chr MT:14,136...15,278
JBrowse link
G Mt-nd2 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of ND2 mRNA] CTD PMID:30104959 NCBI chr MT:3,904...4,942
Ensembl chr MT:3,904...4,942
JBrowse link
G Mt-nd5 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of ND5 mRNA] CTD PMID:30104959 NCBI chr MT:11,736...13,565
Ensembl chr MT:11,736...13,565
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP
ISO
trilobatin promotes the reaction [Hydrogen Peroxide affects the localization of NFE2L2 protein]
NFE2L2 protein affects the reaction [trilobatin inhibits the reaction [Isoflurane results in decreased activity of CAT protein]]; trilobatin promotes the reaction [Isoflurane results in increased expression of NFE2L2 protein]
CTD PMID:30104959, PMID:32663520 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO trilobatin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein] CTD PMID:25053100 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP
ISO
trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of NQO1 protein]
trilobatin promotes the reaction [Isoflurane results in increased expression of NQO1 mRNA]; trilobatin promotes the reaction [Isoflurane results in increased expression of NQO1 protein]
CTD PMID:30104959, PMID:32663520 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of PPARGC1A protein] CTD PMID:30104959 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO trilobatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] CTD PMID:25053100 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sirt3 sirtuin 3 multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT3 mRNA]; trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT3 protein] CTD PMID:30104959 NCBI chr 1:213,613,502...213,636,061
Ensembl chr 1:213,613,513...213,635,546
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased activity of SOD2 protein]; trilobatin inhibits the reaction [Hydrogen Peroxide results in increased acetylation of SOD2 protein] CTD PMID:30104959 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO trilobatin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; trilobatin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; trilobatin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:25053100 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide results in increased expression of UCP2 protein] CTD PMID:30104959 NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        pharmaceutical 19272
          drug 19272
            antineoplastic agent 16982
              phloretin 275
                3-hydroxyphloretin 2'-O-xylosylglucoside 0
                asebogenin 0
                glycyphyllin 0
                phlorizin 229
                trilobatin 25
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      ketone 16140
                                        aromatic ketone 11902
                                          dihydrochalcones 705
                                            dihydrochalcone 275
                                              phloretin 275
                                                3-hydroxyphloretin 2'-O-xylosylglucoside 0
                                                asebogenin 0
                                                glycyphyllin 0
                                                phlorizin 229
                                                trilobatin 25
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.