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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:phloretin
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Accession:CHEBI:17276 term browser browse the term
Definition:A member of the class of dihydrochalcones that is dihydrochalcone substituted by hydroxy groups at positions 4, 2', 4' and 6'.
Synonyms:exact_synonym: 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one
 related_synonym: 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone;   Formula=C15H14O5;   InChI=1S/C15H14O5/c16-10-4-1-9(2-5-10)3-6-12(18)15-13(19)7-11(17)8-14(15)20/h1-2,4-5,7-8,16-17,19-20H,3,6H2;   InChIKey=VGEREEWJJVICBM-UHFFFAOYSA-N;   SMILES=Oc1ccc(CCC(=O)c2c(O)cc(O)cc2O)cc1
 alt_id: CHEBI:14787;   CHEBI:26014;   CHEBI:42649;   CHEBI:8111
 xref: CAS:60-82-2;   DrugBank:DB07810;   HMDB:HMDB0003306;   KEGG:C00774;   KNApSAcK:C00007936;   LINCS:LSM-6221;   LIPID_MAPS_instance:LMPK12120525
 xref_mesh: MESH:D010693
 xref: MetaCyc:PHLORETIN;   PDBeChem:G50;   PMID:18767070;   PMID:23907072;   PMID:24487097;   PMID:7126563;   Patent:CN102701938;   Patent:CN103230408;   Reaxys:1887240;   Wikipedia:Phloretin


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phloretin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions ISO [[sodium arsenite results in increased abundance of Arsenic] which co-treated with Phloretin] results in increased activity of ACHE protein CTD PMID:33410021 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Afp alpha-fetoprotein affects binding EXP Phloretin binds to AFP protein CTD PMID:23013281 PMID:25349334 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
JBrowse link
G Aqp9 aquaporin 9 multiple interactions
decreases activity
EXP
ISO
Phloretin inhibits the reaction [AQP9 protein results in increased transport of Water]; Phloretin inhibits the reaction [CFTR protein promotes the reaction [AQP9 protein affects the transport of Water]]
Phloretin inhibits the reaction [AQP9 protein results in increased uptake of Lactic Acid]; Phloretin inhibits the reaction [AQP9 protein results in increased uptake of Selenic Acid analog]; Phloretin inhibits the reaction [AQP9 protein results in increased uptake of Selenious Acid]
Phloretin results in decreased activity of AQP9 protein
CTD PMID:9733774 PMID:12606488 PMID:21259319 PMID:28798983 NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395
JBrowse link
G Bche butyrylcholinesterase multiple interactions ISO Phloretin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased activity of BCHE protein] CTD PMID:33410021 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Phloretin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein] CTD PMID:24707119 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Phloretin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL5 protein] CTD PMID:24707119 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions EXP Phloretin inhibits the reaction [CFTR protein promotes the reaction [AQP9 protein affects the transport of Water]] CTD PMID:12606488 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Csf3 colony stimulating factor 3 multiple interactions ISO Phloretin inhibits the reaction [Lipopolysaccharides results in increased expression of CSF3 protein] CTD PMID:24707119 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Phloretin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Phloretin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Phloretin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein] CTD PMID:17177569 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Phloretin binds to and results in increased activity of ESR1 protein CTD PMID:9751507 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
affects binding
ISO Phloretin binds to and results in increased activity of ESR2 protein
Phloretin binds to ESR2 protein
CTD PMID:9751507 PMID:12224631 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO Phloretin inhibits the reaction [Acetaminophen results in increased activity of GPT protein] CTD PMID:30287234 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases activity ISO Phloretin results in decreased activity of GSK3B protein CTD PMID:16968061 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Ifng interferon gamma multiple interactions ISO Phloretin inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein] CTD PMID:24707119 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Phloretin inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein] CTD PMID:24707119 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Phloretin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A protein] CTD PMID:24707119 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Phloretin inhibits the reaction [Uric Acid results in increased secretion of IL1B protein] CTD PMID:21051542 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions ISO Phloretin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1RN protein] CTD PMID:24707119 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Phloretin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:24707119 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ins2 insulin 2 multiple interactions ISO Phloretin inhibits the reaction [[chromic chloride results in increased activity of INS protein modified form] which results in increased secretion of Adenosine Triphosphate] CTD PMID:17965850 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 affects response to substance EXP KCNMA1 mRNA affects the susceptibility to Phloretin CTD PMID:19247476 NCBI chr15:302,078...1,001,198
Ensembl chr15:302,214...1,001,198
JBrowse link
G Ltf lactotransferrin increases expression EXP Phloretin results in increased expression of LTF protein CTD PMID:24487097 NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO [[sodium arsenite results in increased abundance of Arsenic] which co-treated with Phloretin] results in increased expression of NFE2L2 mRNA CTD PMID:33410021 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nos3 nitric oxide synthase 3 decreases expression
multiple interactions
ISO Phloretin results in decreased expression of NOS3 mRNA
Phloretin inhibits the reaction [Hydrogen Peroxide results in increased expression of NOS3 mRNA]
CTD PMID:20021702 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Shbg sex hormone binding globulin affects binding ISO Phloretin binds to SHBG protein CTD PMID:25349334 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057
JBrowse link
G Slc14a1 solute carrier family 14 member 1 (Kidd blood group) multiple interactions EXP Phloretin inhibits the reaction [SLC14A1 protein results in increased transport of Urea] CTD PMID:8982255 NCBI chr18:71,565,453...71,608,807
Ensembl chr18:71,565,454...71,595,146
JBrowse link
G Slc14a2 solute carrier family 14 member 2 multiple interactions EXP Phloretin inhibits the reaction [SLC14A2 protein results in increased transport of Urea] CTD PMID:11181411 NCBI chr18:71,612,460...72,039,462
Ensembl chr18:71,612,460...71,792,968
JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions EXP [[Luteolin co-treated with Phloretin] results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate; [Phloretin results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate CTD PMID:17108059 NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611
JBrowse link
G Slc16a2 solute carrier family 16 member 2 multiple interactions ISO Phloretin inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine] CTD PMID:28119167 NCBI chr  X:68,725,365...68,848,572
Ensembl chr  X:68,723,261...68,848,771
JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions
decreases activity
ISO Phloretin inhibits the reaction [SLC2A1 protein affects the transport of Glucose]
Phloretin results in decreased activity of SLC2A1 protein
CTD PMID:14642735 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Slc2a2 solute carrier family 2 member 2 multiple interactions
decreases expression
ISO
EXP
Phloretin inhibits the reaction [Fluorouracil promotes the reaction [SLC2A2 protein results in increased uptake of 3-O-Methylglucose]]; Phloretin inhibits the reaction [SLC2A2 protein results in increased uptake of 3-O-Methylglucose]
Phloretin results in decreased expression of SLC2A2 protein
Phloretin inhibits the reaction [SLC2A2 protein results in increased uptake of Glucose]
CTD PMID:15986457 PMID:17272349 PMID:26616219 NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933
JBrowse link
G Slc2a9 solute carrier family 2 member 9 multiple interactions ISO Phloretin inhibits the reaction [SLC2A9 protein results in increased uptake of Uric Acid] CTD PMID:19587147 NCBI chr14:72,328,334...72,461,981
Ensembl chr14:72,328,320...72,461,981
JBrowse link
G Slc9a1 solute carrier family 9 member A1 multiple interactions
decreases activity
ISO Phloretin inhibits the reaction [SLC9A1 protein alternative form affects the transport of [Sodium co-treated with Lithium]]
Phloretin results in decreased activity of SLC9A1 protein; Phloretin results in decreased activity of SLC9A1 protein alternative form
CTD PMID:12765964 NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624
JBrowse link
G Slc9b2 solute carrier family 9 member B2 decreases activity ISO Phloretin results in decreased activity of SLC9B2 protein CTD PMID:18000046 NCBI chr 2:223,726,982...223,761,234
Ensembl chr 2:223,736,354...223,761,225
JBrowse link
phlorizin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abat 4-aminobutyrate aminotransferase decreases expression ISO Phlorhizin results in decreased expression of ABAT mRNA CTD PMID:22538082 NCBI chr10:6,996,688...7,092,835
Ensembl chr10:6,999,819...7,092,835
JBrowse link
G Acaa1b acetyl-Coenzyme A acyltransferase 1B increases expression ISO Phlorhizin results in increased expression of ACAA1 mRNA CTD PMID:22538082 NCBI chr 8:118,872,996...118,881,852
Ensembl chr 8:118,872,997...118,881,825
JBrowse link
G Acaa2 acetyl-CoA acyltransferase 2 decreases expression ISO Phlorhizin results in decreased expression of ACAA2 mRNA CTD PMID:22538082 NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249
JBrowse link
G Acad8 acyl-CoA dehydrogenase family, member 8 decreases expression ISO Phlorhizin results in decreased expression of ACAD8 mRNA CTD PMID:22538082 NCBI chr 8:25,382,271...25,406,429
Ensembl chr 8:25,382,273...25,406,414
JBrowse link
G Acad9 acyl-CoA dehydrogenase family, member 9 decreases expression ISO Phlorhizin results in decreased expression of ACAD9 mRNA CTD PMID:22538082 NCBI chr 2:118,943,170...118,966,150
Ensembl chr 2:118,943,174...118,966,547
JBrowse link
G Acadl acyl-CoA dehydrogenase, long chain decreases expression ISO Phlorhizin results in decreased expression of ACADL mRNA CTD PMID:22538082 NCBI chr 9:68,333,981...68,372,149
Ensembl chr 9:68,333,980...68,372,220
JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain decreases expression ISO Phlorhizin results in decreased expression of ACADM mRNA CTD PMID:22538082 NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147
JBrowse link
G Acat1 acetyl-CoA acetyltransferase 1 decreases expression ISO Phlorhizin results in decreased expression of ACAT1 mRNA CTD PMID:22538082 NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855
JBrowse link
G Aco1 aconitase 1 decreases expression ISO Phlorhizin results in decreased expression of ACO1 mRNA CTD PMID:22538082 NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391
JBrowse link
G Acox1 acyl-CoA oxidase 1 decreases expression ISO Phlorhizin results in decreased expression of ACOX1 mRNA CTD PMID:22538082 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Acox2 acyl-CoA oxidase 2 decreases expression ISO Phlorhizin results in decreased expression of ACOX2 mRNA CTD PMID:22538082 NCBI chr15:16,660,584...16,692,160
Ensembl chr15:16,660,272...16,692,160
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 decreases expression ISO Phlorhizin results in decreased expression of ACSL1 mRNA CTD PMID:22538082 NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541
JBrowse link
G Actb actin, beta increases expression ISO Phlorhizin results in increased expression of ACTB mRNA CTD PMID:22538082 NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
JBrowse link
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide decreases expression ISO Phlorhizin results in decreased expression of ADH5 mRNA CTD PMID:22538082 NCBI chr 2:226,975,184...226,987,591 JBrowse link
G Adhfe1 alcohol dehydrogenase, iron containing, 1 decreases expression ISO Phlorhizin results in decreased expression of ADHFE1 mRNA CTD PMID:22538082 NCBI chr 5:9,705,966...9,732,580
Ensembl chr 5:9,705,970...9,732,517
JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 decreases expression ISO Phlorhizin results in decreased expression of AKR1A1 mRNA CTD PMID:22538082 NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674
JBrowse link
G Akr7a2 aldo-keto reductase family 7, member A2 increases expression ISO Phlorhizin results in increased expression of AKR7A2 mRNA CTD PMID:22538082 NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909
JBrowse link
G Alb albumin multiple interactions ISO Phlorhizin inhibits the reaction [Glucose results in decreased uptake of ALB protein] CTD PMID:16313995 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member decreases expression
increases expression
ISO Phlorhizin results in decreased expression of ALDH2 mRNA
Phlorhizin results in increased expression of ALDH2 mRNA
CTD PMID:22538082 NCBI chr12:34,949,549...34,982,527 JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 decreases expression ISO Phlorhizin results in decreased expression of ALDH3A2 mRNA CTD PMID:22538082 NCBI chr10:45,928,313...45,949,366
Ensembl chr10:45,908,524...45,949,281
JBrowse link
G Aldh4a1 aldehyde dehydrogenase 4 family, member A1 decreases expression ISO Phlorhizin results in decreased expression of ALDH4A1 mRNA CTD PMID:22538082 NCBI chr 5:151,880,002...151,905,491 JBrowse link
G Aldh6a1 aldehyde dehydrogenase 6 family, member A1 decreases expression ISO Phlorhizin results in decreased expression of ALDH6A1 mRNA CTD PMID:22538082 NCBI chr 6:104,077,975...104,098,636
Ensembl chr 6:104,077,979...104,098,656
JBrowse link
G Aldh7a1 aldehyde dehydrogenase 7 family, member A1 decreases expression ISO Phlorhizin results in decreased expression of ALDH7A1 mRNA CTD PMID:22538082 NCBI chr18:50,003,242...50,042,193
Ensembl chr18:50,009,934...50,042,193
JBrowse link
G Anapc2 anaphase promoting complex subunit 2 decreases expression ISO Phlorhizin results in decreased expression of ANAPC2 mRNA CTD PMID:22538082 NCBI chr 3:8,086,434...8,098,182
Ensembl chr 3:8,086,462...8,098,178
JBrowse link
G Anapc5 anaphase-promoting complex subunit 5 decreases expression ISO Phlorhizin results in decreased expression of ANAPC5 mRNA CTD PMID:22538082 NCBI chr12:33,748,714...33,781,709
Ensembl chr12:33,748,735...33,781,781
JBrowse link
G Aox1 aldehyde oxidase 1 decreases expression ISO Phlorhizin results in decreased expression of AOX1 mRNA CTD PMID:22538082 NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770
JBrowse link
G Aph1b aph-1 homolog B, gamma secretase subunit increases expression ISO Phlorhizin results in increased expression of APH1B mRNA CTD PMID:22538082 NCBI chr 8:67,429,198...67,454,735
Ensembl chr 8:67,429,198...67,450,243
JBrowse link
G App amyloid beta precursor protein decreases expression ISO Phlorhizin results in decreased expression of APP mRNA CTD PMID:22538082 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Atf3 activating transcription factor 3 decreases expression ISO Phlorhizin results in decreased expression of ATF3 mRNA CTD PMID:16123366 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 increases expression ISO Phlorhizin results in increased expression of ATP2A2 mRNA CTD PMID:16123366 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha decreases expression ISO Phlorhizin results in decreased expression of ATP5A1 mRNA CTD PMID:22538082 NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794
JBrowse link
G Atp5f1c ATP synthase F1 subunit gamma increases expression ISO Phlorhizin results in increased expression of ATP5C1 mRNA CTD PMID:22538082 NCBI chr17:68,423,927...68,446,169 JBrowse link
G Auh AU RNA binding methylglutaconyl-CoA hydratase decreases expression ISO Phlorhizin results in decreased expression of AUH mRNA CTD PMID:22538082 NCBI chr17:12,329,522...12,424,896
Ensembl chr17:12,329,524...12,424,896
JBrowse link
G B2m beta-2 microglobulin increases expression ISO Phlorhizin results in increased expression of B2M mRNA CTD PMID:22538082 NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
JBrowse link
G Bag1 BAG cochaperone 1 decreases expression ISO Phlorhizin results in decreased expression of BAG1 mRNA CTD PMID:22538082 NCBI chr 5:56,068,494...56,081,075
Ensembl chr 5:56,068,494...56,081,075
JBrowse link
G Bckdhb branched chain keto acid dehydrogenase E1 subunit beta decreases expression ISO Phlorhizin results in decreased expression of BCKDHB mRNA CTD PMID:22538082 NCBI chr 8:84,845,264...85,027,812
Ensembl chr 8:84,845,264...85,027,812
JBrowse link
G Birc6 baculoviral IAP repeat-containing 6 increases expression ISO Phlorhizin results in increased expression of BIRC6 mRNA CTD PMID:22538082 NCBI chr 6:20,722,922...20,916,396
Ensembl chr 6:20,722,922...20,916,434
JBrowse link
G Cat catalase increases expression ISO Phlorhizin results in increased expression of CAT mRNA CTD PMID:22538082 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cct7 chaperonin containing TCP1 subunit 7 decreases expression ISO Phlorhizin results in decreased expression of CCT7 mRNA CTD PMID:22538082 NCBI chr 4:117,989,232...118,006,478
Ensembl chr 4:117,989,232...118,006,580
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions EXP Phlorhizin inhibits the reaction [Streptozocin results in increased expression of CHRM2 mRNA]; Phlorhizin inhibits the reaction [Streptozocin results in increased expression of CHRM2 protein] CTD PMID:18715473 NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103
JBrowse link
G Clybl citramalyl-CoA lyase decreases expression ISO Phlorhizin results in decreased expression of CLYBL mRNA CTD PMID:22538082 NCBI chr15:99,283,644...99,505,697
Ensembl chr15:99,283,650...99,505,695
JBrowse link
G Cox15 cytochrome c oxidase assembly homolog COX15 decreases expression ISO Phlorhizin results in decreased expression of COX15 mRNA CTD PMID:22538082 NCBI chr 1:242,605,588...242,622,279
Ensembl chr 1:242,605,588...242,622,261
JBrowse link
G Cox17 cytochrome c oxidase copper chaperone COX17 decreases expression ISO Phlorhizin results in decreased expression of COX17 mRNA CTD PMID:22538082 NCBI chr11:62,400,733...62,406,507 JBrowse link
G Cox7c cytochrome c oxidase subunit 7C increases expression ISO Phlorhizin results in increased expression of COX7C mRNA CTD PMID:22538082 NCBI chr 2:16,841,771...16,843,796
Ensembl chr 2:16,840,837...16,843,760
JBrowse link
G Cox8a cytochrome c oxidase subunit 8A decreases expression ISO Phlorhizin results in decreased expression of COX8A mRNA CTD PMID:22538082 NCBI chr 1:204,402,118...204,404,439 JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression ISO Phlorhizin results in decreased expression of CPT1A mRNA CTD PMID:16123366 PMID:22538082 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 decreases expression ISO Phlorhizin results in decreased expression of CPT2 mRNA CTD PMID:22538082 NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095
JBrowse link
G Crebbp CREB binding protein decreases expression ISO Phlorhizin results in decreased expression of CREBBP mRNA CTD PMID:22538082 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
JBrowse link
G Cs citrate synthase decreases expression ISO Phlorhizin results in decreased expression of CS mRNA CTD PMID:22538082 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421
JBrowse link
G Cul1 cullin 1 decreases expression ISO Phlorhizin results in decreased expression of CUL1 mRNA CTD PMID:22538082 NCBI chr 4:76,551,952...76,625,830
Ensembl chr 4:76,551,983...76,627,980
JBrowse link
G Cyb5r3 cytochrome b5 reductase 3 decreases expression ISO Phlorhizin results in decreased expression of CYB5R3 mRNA CTD PMID:22538082 NCBI chr 7:114,306,686...114,324,247
Ensembl chr 7:114,306,685...114,324,298
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases expression ISO Phlorhizin results in decreased expression of CYP1A2 mRNA CTD PMID:22538082 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases expression ISO Phlorhizin results in decreased expression of CYP2B6 mRNA CTD PMID:22538082 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases expression ISO Phlorhizin results in increased expression of CYP2D6 mRNA CTD PMID:22538082 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 decreases expression
increases expression
ISO Phlorhizin results in decreased expression of CYP3A7 mRNA
Phlorhizin results in increased expression of CYP3A7 mRNA
CTD PMID:22538082 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 increases expression ISO Phlorhizin results in increased expression of CYP4A11 mRNA CTD PMID:22538082 NCBI chr 5:129,139,019...129,176,860
Ensembl chr 5:129,139,038...129,156,348
JBrowse link
G Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 decreases expression ISO Phlorhizin results in decreased expression of CYP4F12 mRNA CTD PMID:22538082 NCBI chr 7:12,010,850...12,022,497
Ensembl chr 7:12,010,852...12,022,046
JBrowse link
G Dhrs4 dehydrogenase/reductase 4 decreases expression ISO Phlorhizin results in decreased expression of DHRS4 mRNA CTD PMID:22538082 NCBI chr15:28,966,544...28,978,135
Ensembl chr15:28,966,553...28,978,127
JBrowse link
G Dld dihydrolipoamide dehydrogenase decreases expression ISO Phlorhizin results in decreased expression of DLD mRNA CTD PMID:22538082 NCBI chr 6:47,904,153...47,924,814
Ensembl chr 6:47,903,914...47,924,795
JBrowse link
G Dnaja2 DnaJ heat shock protein family (Hsp40) member A2 decreases expression ISO Phlorhizin results in decreased expression of DNAJA2 mRNA CTD PMID:22538082 NCBI chr19:21,497,792...21,516,904
Ensembl chr19:21,497,729...21,516,901
JBrowse link
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 decreases expression ISO Phlorhizin results in decreased expression of DNAJA3 mRNA CTD PMID:22538082 NCBI chr10:10,855,510...10,880,175
Ensembl chr10:10,854,732...10,880,161
JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 decreases expression
increases expression
ISO Phlorhizin results in decreased expression of DNAJB1 mRNA
Phlorhizin results in increased expression of DNAJB1 mRNA
CTD PMID:22538082 NCBI chr19:24,522,717...24,526,458
Ensembl chr19:24,522,717...24,526,458
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 decreases expression ISO Phlorhizin results in decreased expression of DNAJB4 mRNA CTD PMID:22538082 NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089
JBrowse link
G Dnajb6 DnaJ heat shock protein family (Hsp40) member B6 increases expression ISO Phlorhizin results in increased expression of DNAJB6 mRNA CTD PMID:22538082 NCBI chr 4:5,452,683...5,556,679
Ensembl chr 4:5,452,683...5,556,659
JBrowse link
G Dnajc1 DnaJ heat shock protein family (Hsp40) member C1 decreases expression ISO Phlorhizin results in decreased expression of DNAJC1 mRNA CTD PMID:22538082 NCBI chr17:80,955,209...81,112,025
Ensembl chr17:80,955,237...81,111,988
JBrowse link
G Dnajc13 DnaJ heat shock protein family (Hsp40) member C13 decreases expression ISO Phlorhizin results in decreased expression of DNAJC13 mRNA CTD PMID:22538082 NCBI chr 8:104,767,785...104,877,317
Ensembl chr 8:104,767,788...104,877,317
JBrowse link
G Dnajc14 DnaJ heat shock protein family (Hsp40) member C14 increases expression ISO Phlorhizin results in increased expression of DNAJC14 mRNA CTD PMID:22538082 NCBI chr 7:1,233,856...1,247,349
Ensembl chr 7:1,235,162...1,248,645
JBrowse link
G Dnajc19 DnaJ heat shock protein family (Hsp40) member C19 decreases expression ISO Phlorhizin results in decreased expression of DNAJC19 mRNA CTD PMID:22538082 NCBI chr 2:116,923,272...116,945,312
Ensembl chr 2:116,923,272...116,945,264
JBrowse link
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 decreases expression ISO Phlorhizin results in decreased expression of DNAJC3 mRNA CTD PMID:22538082 NCBI chr15:96,025,729...96,065,114
Ensembl chr15:96,025,624...96,065,181
JBrowse link
G Dnajc4 DnaJ heat shock protein family (Hsp40) member C4 increases expression ISO Phlorhizin results in increased expression of DNAJC4 mRNA CTD PMID:22538082 NCBI chr 1:204,178,189...204,182,412
Ensembl chr 1:204,178,191...204,182,387
JBrowse link
G Dnajc5 DnaJ heat shock protein family (Hsp40) member C5 decreases expression ISO Phlorhizin results in decreased expression of DNAJC5 mRNA CTD PMID:22538082 NCBI chr 3:168,621,905...168,656,570
Ensembl chr 3:168,621,969...168,655,935
JBrowse link
G Echs1 enoyl-CoA hydratase, short chain 1 decreases expression ISO Phlorhizin results in decreased expression of ECHS1 mRNA CTD PMID:22538082 NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884
JBrowse link
G Ep300 E1A binding protein p300 decreases expression ISO Phlorhizin results in decreased expression of EP300 mRNA CTD PMID:22538082 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
JBrowse link
G Ephx1 epoxide hydrolase 1 decreases expression ISO Phlorhizin results in decreased expression of EPHX1 mRNA CTD PMID:22538082 NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235
JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO Phlorhizin results in decreased expression of FAS mRNA CTD PMID:16123366 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fbxw7 F-box and WD repeat domain containing 7 decreases expression ISO Phlorhizin results in decreased expression of FBXW7 mRNA CTD PMID:22538082 NCBI chr 2:170,150,552...170,310,698
Ensembl chr 2:170,149,694...170,309,941
JBrowse link
G Fh fumarate hydratase decreases expression ISO Phlorhizin results in decreased expression of FH mRNA CTD PMID:22538082 NCBI chr13:87,524,331...87,550,215
Ensembl chr13:87,524,337...87,550,266
JBrowse link
G Fis1 fission, mitochondrial 1 increases expression ISO Phlorhizin results in increased expression of FIS1 mRNA CTD PMID:22538082 NCBI chr12:19,708,558...19,723,392
Ensembl chr12:19,708,558...19,723,377
JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 decreases expression ISO Phlorhizin results in decreased expression of FKBP5 mRNA CTD PMID:22538082 NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674
JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 decreases expression ISO Phlorhizin results in decreased expression of FMO1 mRNA CTD PMID:22538082 NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions EXP Phlorhizin inhibits the reaction [Streptozocin results in increased expression of G6PC1 mRNA] CTD PMID:12446591 NCBI chr10:86,307,400...86,318,766 JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit decreases expression ISO Phlorhizin results in decreased expression of GCLC mRNA CTD PMID:22538082 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit decreases expression ISO Phlorhizin results in decreased expression of GCLM mRNA CTD PMID:22538082 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Glrx2 glutaredoxin 2 decreases expression ISO Phlorhizin results in decreased expression of GLRX2 mRNA CTD PMID:22538082 NCBI chr13:55,481,875...55,504,737
Ensembl chr13:55,482,694...55,492,831
JBrowse link
G Gpd2 glycerol-3-phosphate dehydrogenase 2 increases expression
decreases expression
ISO Phlorhizin results in increased expression of GPD2 mRNA
Phlorhizin results in decreased expression of GPD2 mRNA
CTD PMID:16123366 PMID:22538082 NCBI chr 3:41,800,552...41,937,729
Ensembl chr 3:41,801,930...41,936,901
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression ISO Phlorhizin results in decreased expression of GPX1 mRNA CTD PMID:16123366 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gpx7 glutathione peroxidase 7 increases expression ISO Phlorhizin results in increased expression of GPX7 mRNA CTD PMID:22538082 NCBI chr 5:123,145,151...123,153,141
Ensembl chr 5:123,144,331...123,153,004
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 decreases expression ISO Phlorhizin results in decreased expression of GSTA5 mRNA CTD PMID:22538082 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
JBrowse link
G Gstk1 glutathione S-transferase kappa 1 decreases expression ISO Phlorhizin results in decreased expression of GSTK1 mRNA CTD PMID:22538082 NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292
JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases expression ISO Phlorhizin results in decreased expression of GSTM1 mRNA CTD PMID:22538082 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression ISO Phlorhizin results in increased expression of GSTM2 mRNA CTD PMID:22538082 NCBI chr 2:195,624,015...195,628,774 JBrowse link
G Gstm4 glutathione S-transferase mu 4 increases expression ISO Phlorhizin results in increased expression of GSTM4 mRNA CTD PMID:22538082 NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 decreases expression
increases expression
ISO Phlorhizin results in decreased expression of GSTM5 mRNA
Phlorhizin results in increased expression of GSTM5 mRNA
CTD PMID:22538082 NCBI chr 2:195,531,627...195,534,562
Ensembl chr 2:195,531,495...195,534,553
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression ISO Phlorhizin results in increased expression of GSTP1 mRNA CTD PMID:22538082 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Gstt1 glutathione S-transferase theta 1 decreases expression
increases expression
ISO Phlorhizin results in decreased expression of GSTT1 mRNA
Phlorhizin results in increased expression of GSTT1 mRNA
CTD PMID:22538082 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
JBrowse link
G Gstt2 glutathione S-transferase, theta 2 decreases expression ISO Phlorhizin results in decreased expression of GSTT2B mRNA CTD PMID:22538082 NCBI chr20:12,819,617...12,823,288
Ensembl chr20:12,819,170...12,823,288
JBrowse link
G Hacd3 3-hydroxyacyl-CoA dehydratase 3 decreases expression ISO Phlorhizin results in decreased expression of HACD3 mRNA CTD PMID:22538082 NCBI chr 8:65,501,240...65,538,507
Ensembl chr 8:65,501,240...65,538,507
JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta increases expression ISO Phlorhizin results in increased expression of HADHB mRNA CTD PMID:22538082 NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869
JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 decreases expression ISO Phlorhizin results in decreased expression of HERPUD1 mRNA CTD PMID:22538082 NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424
JBrowse link
G Hibadh 3-hydroxyisobutyrate dehydrogenase decreases expression ISO Phlorhizin results in decreased expression of HIBADH mRNA CTD PMID:22538082 NCBI chr 4:81,649,180...81,747,244
Ensembl chr 4:81,649,175...81,780,617
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 decreases expression ISO Phlorhizin results in decreased expression of HMGCS1 mRNA CTD PMID:22538082 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
JBrowse link
G Hmox1 heme oxygenase 1 decreases expression ISO Phlorhizin results in decreased expression of HMOX1 mRNA CTD PMID:16123366 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hras HRas proto-oncogene, GTPase increases expression ISO Phlorhizin results in increased expression of HRAS mRNA CTD PMID:22538082 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 decreases expression ISO Phlorhizin results in decreased expression of HSD17B10 mRNA CTD PMID:22538082 NCBI chr  X:21,089,152...21,091,597
Ensembl chr  X:21,089,122...21,109,488
JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 decreases expression ISO Phlorhizin results in decreased expression of HSD17B4 mRNA CTD PMID:22538082 NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 decreases expression ISO Phlorhizin results in decreased expression of HSP90AA1 mRNA CTD PMID:22538082 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 decreases expression ISO Phlorhizin results in decreased expression of HSP90AB1 mRNA CTD PMID:22538082 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488
JBrowse link
G Hspa13 heat shock protein family A (Hsp70) member 13 decreases expression ISO Phlorhizin results in decreased expression of HSPA13 mRNA CTD PMID:22538082 NCBI chr11:14,375,669...14,389,853
Ensembl chr11:14,373,275...14,389,895
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Phlorhizin results in increased expression of HSPA5 mRNA CTD PMID:22538082 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression ISO Phlorhizin results in increased expression of HSPA8 mRNA CTD PMID:22538082 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 decreases expression ISO Phlorhizin results in decreased expression of HSPA9 mRNA CTD PMID:22538082 NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression ISO Phlorhizin results in increased expression of HSPB1 mRNA CTD PMID:22538082 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
JBrowse link
G Hspb8 heat shock protein family B (small) member 8 decreases expression ISO Phlorhizin results in decreased expression of HSPB8 mRNA CTD PMID:22538082 NCBI chr12:40,176,405...40,205,002
Ensembl chr12:40,176,532...40,191,185
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 decreases expression ISO Phlorhizin results in decreased expression of HSPD1 mRNA CTD PMID:22538082 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 decreases expression ISO Phlorhizin results in decreased expression of HSPE1 mRNA CTD PMID:22538082 NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089
JBrowse link
G Htra2 HtrA serine peptidase 2 decreases expression ISO Phlorhizin results in decreased expression of HTRA2 mRNA CTD PMID:22538082 NCBI chr 4:115,556,914...115,560,202
Ensembl chr 4:115,556,916...115,560,095
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein decreases expression ISO Phlorhizin results in decreased expression of ID1 mRNA CTD PMID:16123366 NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 increases expression ISO Phlorhizin results in increased expression of IDH2 mRNA CTD PMID:22538082 NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
JBrowse link
G Idh3a isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha decreases expression ISO Phlorhizin results in decreased expression of IDH3A mRNA CTD PMID:22538082 NCBI chr 8:54,971,694...54,991,085
Ensembl chr 8:54,971,740...54,991,084
JBrowse link
G Idh3b isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta decreases expression ISO Phlorhizin results in decreased expression of IDH3B mRNA CTD PMID:22538082 NCBI chr 3:117,481,845...117,486,909
Ensembl chr 3:117,481,845...117,486,982
JBrowse link
G Idh3g isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma decreases expression ISO Phlorhizin results in decreased expression of IDH3G mRNA CTD PMID:22538082 NCBI chr  X:151,515,244...151,524,175
Ensembl chr  X:151,515,247...151,524,171
JBrowse link
G Ivd isovaleryl-CoA dehydrogenase decreases expression ISO Phlorhizin results in decreased expression of IVD mRNA CTD PMID:22538082 NCBI chr 3:105,851,710...105,872,144
Ensembl chr 3:105,851,683...105,872,575
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Phlorhizin results in decreased expression of JUNB mRNA CTD PMID:22538082 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit increases expression ISO Phlorhizin results in increased expression of JUND mRNA CTD PMID:22538082 NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799
JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 increases expression ISO Phlorhizin results in increased expression of KCNJ11 mRNA CTD PMID:16123366 NCBI chr 1:96,591,048...96,594,574
Ensembl chr 1:96,591,049...96,594,082
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 increases expression ISO Phlorhizin results in increased expression of KEAP1 mRNA CTD PMID:22538082 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Kras KRAS proto-oncogene, GTPase decreases expression ISO Phlorhizin results in decreased expression of KRAS mRNA CTD PMID:22538082 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Maf MAF bZIP transcription factor decreases expression ISO Phlorhizin results in decreased expression of MAF mRNA CTD PMID:22538082 NCBI chr19:43,353,867...43,713,162
Ensembl chr19:43,360,342...43,712,365
JBrowse link
G Mafg MAF bZIP transcription factor G decreases expression ISO Phlorhizin results in decreased expression of MAFG mRNA CTD PMID:22538082 NCBI chr10:105,903,307...105,911,845
Ensembl chr10:105,903,237...105,912,026
JBrowse link
G Maob monoamine oxidase B decreases expression ISO Phlorhizin results in decreased expression of MAOB mRNA CTD PMID:22538082 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 increases expression ISO Phlorhizin results in increased expression of MAP2K2 mRNA CTD PMID:22538082 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 increases expression ISO Phlorhizin results in increased expression of MAP2K6 mRNA CTD PMID:22538082 NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293
JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 increases expression ISO Phlorhizin results in increased expression of MAP2K7 mRNA CTD PMID:22538082 NCBI chr12:2,591,312...2,604,211
Ensembl chr12:2,591,219...2,604,222
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 decreases expression ISO Phlorhizin results in decreased expression of MAP3K7 mRNA CTD PMID:22538082 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases expression ISO Phlorhizin results in increased expression of MAPK3 mRNA CTD PMID:22538082 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 decreases expression ISO Phlorhizin results in decreased expression of MAPK9 mRNA CTD PMID:22538082 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mccc2 methylcrotonyl-CoA carboxylase subunit 2 decreases expression ISO Phlorhizin results in decreased expression of MCCC2 mRNA CTD PMID:22538082 NCBI chr 2:31,304,927...31,375,978
Ensembl chr 2:31,304,932...31,375,972
JBrowse link
G Mdm2 MDM2 proto-oncogene decreases expression ISO Phlorhizin results in decreased expression of MDM2 mRNA CTD PMID:22538082 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Med20 mediator complex subunit 20 decreases expression ISO Phlorhizin results in decreased expression of MED20 mRNA CTD PMID:22538082 NCBI chr 9:13,370,146...13,382,756
Ensembl chr 9:13,370,146...13,382,476
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 increases expression ISO Phlorhizin results in increased expression of MGST1 mRNA CTD PMID:22538082 NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892
JBrowse link
G Mmut methylmalonyl-CoA mutase decreases expression ISO Phlorhizin results in decreased expression of MMUT mRNA CTD PMID:22538082 NCBI chr 9:19,928,720...19,956,985
Ensembl chr 9:19,928,727...19,957,046
JBrowse link
G Myl9 myosin light chain 9 decreases phosphorylation EXP Phlorhizin results in decreased phosphorylation of MYL9 protein CTD PMID:17272349 NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333
JBrowse link
G Ndufa12 NADH:ubiquinone oxidoreductase subunit A12 increases expression ISO Phlorhizin results in increased expression of NDUFA12 mRNA CTD PMID:22538082 NCBI chr 7:28,771,330...28,798,316
Ensembl chr 7:28,771,330...28,798,315
JBrowse link
G Ndufa2 NADH:ubiquinone oxidoreductase subunit A2 increases expression ISO Phlorhizin results in increased expression of NDUFA2 mRNA CTD PMID:22538082 NCBI chr18:28,355,774...28,357,863
Ensembl chr18:28,355,774...28,358,076
JBrowse link
G Ndufa3 NADH:ubiquinone oxidoreductase subunit A3 decreases expression ISO Phlorhizin results in decreased expression of NDUFA3 mRNA CTD PMID:22538082 NCBI chr 1:65,597,562...65,600,242
Ensembl chr 1:65,597,578...65,600,235
JBrowse link
G Ndufa7 NADH:ubiquinone oxidoreductase subunit A7 increases expression ISO Phlorhizin results in increased expression of NDUFA7 mRNA CTD PMID:22538082 NCBI chr 7:14,609,283...14,622,064 JBrowse link
G Ndufab1 NADH:ubiquinone oxidoreductase subunit AB1 increases expression ISO Phlorhizin results in increased expression of NDUFAB1 mRNA CTD PMID:22538082 NCBI chr 1:176,644,696...176,658,131
Ensembl chr 1:176,644,703...176,658,099
JBrowse link
G Ndufaf1 NADH:ubiquinone oxidoreductase complex assembly factor 1 decreases expression ISO Phlorhizin results in decreased expression of NDUFAF1 mRNA CTD PMID:22538082 NCBI chr 3:106,639,025...106,650,549
Ensembl chr 3:106,639,851...106,650,212
JBrowse link
G Ndufb6 NADH:ubiquinone oxidoreductase subunit B6 decreases expression ISO Phlorhizin results in decreased expression of NDUFB6 mRNA CTD PMID:22538082 NCBI chr 5:55,400,543...55,410,110
Ensembl chr 5:55,400,543...55,410,181
JBrowse link
G Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 decreases expression ISO Phlorhizin results in decreased expression of NDUFS1 mRNA CTD PMID:22538082 NCBI chr 9:64,546,430...64,579,751
Ensembl chr 9:64,546,225...64,579,893
JBrowse link
G Ndufs4 NADH:ubiquinone oxidoreductase subunit S4 decreases expression ISO Phlorhizin results in decreased expression of NDUFS4 mRNA CTD PMID:22538082 NCBI chr 2:45,951,327...46,061,829
Ensembl chr 2:45,951,313...46,061,846
JBrowse link
G Ndufs5 NADH:ubiquinone oxidoreductase subunit S5 decreases expression ISO Phlorhizin results in decreased expression of NDUFS5 mRNA CTD PMID:22538082 NCBI chr 5:135,974,029...135,979,705
Ensembl chr 5:135,974,034...135,979,603
JBrowse link
G Ndufs8 NADH:ubiquinone oxidoreductase core subunit S8 increases expression ISO Phlorhizin results in increased expression of NDUFS8 mRNA CTD PMID:22538082 NCBI chr 1:201,140,585...201,144,573
Ensembl chr 1:201,140,585...201,144,511
JBrowse link
G Nedd4 NEDD4 E3 ubiquitin protein ligase decreases expression ISO Phlorhizin results in decreased expression of NEDD4 mRNA CTD PMID:22538082 NCBI chr 8:73,384,095...73,468,951
Ensembl chr 8:73,383,695...73,468,951
JBrowse link
G Neurod1 neuronal differentiation 1 increases expression ISO Phlorhizin results in increased expression of NEUROD1 mRNA CTD PMID:16123366 NCBI chr 3:64,360,222...64,363,526
Ensembl chr 3:64,359,395...64,363,649
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 decreases expression ISO Phlorhizin results in decreased expression of NFE2L2 mRNA CTD PMID:22538082 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nkx6-1 NK6 homeobox 1 increases expression ISO Phlorhizin results in increased expression of NKX6-1 mRNA CTD PMID:16123366 NCBI chr14:7,969,756...7,976,689
Ensembl chr14:7,969,756...7,976,681
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
decreases expression
ISO Phlorhizin inhibits the reaction [Hydrogen Peroxide results in increased expression of NOS3 mRNA]
Phlorhizin results in decreased expression of NOS3 mRNA
CTD PMID:20021702 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nras NRAS proto-oncogene, GTPase decreases expression ISO Phlorhizin results in decreased expression of NRAS mRNA CTD PMID:22538082 NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626
JBrowse link
G Ogdh oxoglutarate dehydrogenase decreases expression ISO Phlorhizin results in decreased expression of OGDH mRNA CTD PMID:22538082 NCBI chr14:81,150,021...81,217,479
Ensembl chr14:81,150,091...81,217,479
JBrowse link
G Park7 Parkinsonism associated deglycase increases expression ISO Phlorhizin results in increased expression of PARK7 mRNA CTD PMID:22538082 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
JBrowse link
G Pc pyruvate carboxylase increases expression
decreases expression
ISO Phlorhizin results in increased expression of PCX mRNA
Phlorhizin results in decreased expression of PC mRNA
CTD PMID:16123366 PMID:22538082 NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380
JBrowse link
G Pcca propionyl-CoA carboxylase subunit alpha decreases expression ISO Phlorhizin results in decreased expression of PCCA mRNA CTD PMID:22538082 NCBI chr15:99,627,955...99,969,555
Ensembl chr15:99,627,982...99,968,266
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 decreases expression ISO Phlorhizin results in decreased expression of PCK1 mRNA CTD PMID:22538082 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
JBrowse link
G Pecr peroxisomal trans-2-enoyl-CoA reductase increases expression
decreases expression
ISO Phlorhizin results in increased expression of PECR mRNA
Phlorhizin results in decreased expression of PECR mRNA
CTD PMID:22538082 NCBI chr 9:73,897,877...73,926,511
Ensembl chr 9:73,897,880...73,926,511
JBrowse link
G Pik3c2a phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha decreases expression ISO Phlorhizin results in decreased expression of PIK3C2A mRNA CTD PMID:22538082 NCBI chr 1:170,577,942...170,684,353
Ensembl chr 1:170,577,942...170,683,472
JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 decreases expression ISO Phlorhizin results in decreased expression of PIK3C3 mRNA CTD PMID:22538082 NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048
JBrowse link
G Pink1 PTEN induced kinase 1 increases expression ISO Phlorhizin results in increased expression of PINK1 mRNA CTD PMID:22538082 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635
JBrowse link
G Prdx1 peroxiredoxin 1 increases expression ISO Phlorhizin results in increased expression of PRDX1 mRNA CTD PMID:22538082 NCBI chr 5:130,147,276...130,162,850
Ensembl chr 5:130,147,204...130,162,856
JBrowse link
G Prdx5 peroxiredoxin 5 decreases expression ISO Phlorhizin results in decreased expression of PRDX5 mRNA CTD PMID:22538082 NCBI chr 1:204,099,826...204,103,589
Ensembl chr 1:204,099,826...204,114,268
JBrowse link
G Prkch protein kinase C, eta increases expression ISO Phlorhizin results in increased expression of PRKCH mRNA CTD PMID:22538082 NCBI chr 6:92,292,000...92,490,663
Ensembl chr 6:92,292,000...92,490,654
JBrowse link
G Prkci protein kinase C, iota decreases expression ISO Phlorhizin results in decreased expression of PRKCI mRNA CTD PMID:22538082 NCBI chr 2:112,321,919...112,382,305
Ensembl chr 2:112,321,929...112,382,352
JBrowse link
G Prkd3 protein kinase D3 decreases expression ISO Phlorhizin results in decreased expression of PRKD3 mRNA CTD PMID:22538082 NCBI chr 6:16,032,507...16,108,444
Ensembl chr 6:16,032,585...16,108,443
JBrowse link
G Psma4 proteasome 20S subunit alpha 4 decreases expression ISO Phlorhizin results in decreased expression of PSMA4 mRNA CTD PMID:22538082 NCBI chr 8:55,340,431...55,347,893
Ensembl chr 8:55,340,386...55,347,890
JBrowse link
G Psmb1 proteasome 20S subunit beta 1 increases expression ISO Phlorhizin results in increased expression of PSMB1 mRNA CTD PMID:22538082 NCBI chr 1:56,442,432...56,463,544
Ensembl chr 1:56,420,618...56,463,560
JBrowse link
G Psmb2 proteasome 20S subunit beta 2 decreases expression ISO Phlorhizin results in decreased expression of PSMB2 mRNA CTD PMID:22538082 NCBI chr 5:138,970,564...139,002,715
Ensembl chr 5:138,970,533...139,021,137
JBrowse link
G Psmc1 proteasome 26S subunit, ATPase 1 decreases expression ISO Phlorhizin results in decreased expression of PSMC1 mRNA CTD PMID:22538082 NCBI chr 6:119,392,833...119,405,233
Ensembl chr 6:119,392,855...119,410,123
JBrowse link
G Psmc4 proteasome 26S subunit, ATPase 4 increases expression
decreases expression
ISO Phlorhizin results in increased expression of PSMC4 mRNA
Phlorhizin results in decreased expression of PSMC4 mRNA
CTD PMID:22538082 NCBI chr 1:83,349,127...83,357,497
Ensembl chr 1:83,348,592...83,357,494
JBrowse link
G Psmc6 proteasome 26S subunit, ATPase 6 decreases expression ISO Phlorhizin results in decreased expression of PSMC6 mRNA CTD PMID:22538082 NCBI chr15:18,542,585...18,564,057
Ensembl chr15:18,542,563...18,564,055
JBrowse link
G Psmd10 proteasome 26S subunit, non-ATPase 10 decreases expression ISO Phlorhizin results in decreased expression of PSMD10 mRNA CTD PMID:22538082 NCBI chr  X:104,656,809...104,665,126 JBrowse link
G Psmd12 proteasome 26S subunit, non-ATPase 12 decreases expression ISO Phlorhizin results in decreased expression of PSMD12 mRNA CTD PMID:22538082 NCBI chr10:92,438,223...92,457,323
Ensembl chr10:92,438,298...92,457,287
JBrowse link
G Psmd14 proteasome 26S subunit, non-ATPase 14 decreases expression ISO Phlorhizin results in decreased expression of PSMD14 mRNA CTD PMID:22538082 NCBI chr 3:46,254,338...46,347,076
Ensembl chr 3:46,254,330...46,347,076
JBrowse link
G Psmd4 proteasome 26S subunit ubiquitin receptor, non-ATPase 4 decreases expression ISO Phlorhizin results in decreased expression of PSMD4 mRNA CTD PMID:22538082 NCBI chr 2:182,598,934...182,608,250
Ensembl chr 2:182,598,934...182,608,194
JBrowse link
G Psmd6 proteasome 26S subunit, non-ATPase 6 increases expression ISO Phlorhizin results in increased expression of PSMD6 mRNA CTD PMID:22538082 NCBI chr15:11,102,208...11,112,180
Ensembl chr15:11,102,180...11,205,620
JBrowse link
G Psmd7 proteasome 26S subunit, non-ATPase 7 decreases expression ISO Phlorhizin results in decreased expression of PSMD7 mRNA CTD PMID:22538082 NCBI chr19:35,494,317...35,501,605
Ensembl chr19:35,494,316...35,501,588
JBrowse link
G Psmd9 proteasome 26S subunit, non-ATPase 9 decreases expression ISO Phlorhizin results in decreased expression of PSMD9 mRNA CTD PMID:22538082 NCBI chr12:33,337,182...33,357,468 JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases expression ISO Phlorhizin results in decreased expression of RAF1 mRNA CTD PMID:22538082 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Rdh14 retinol dehydrogenase 14 increases expression ISO Phlorhizin results in increased expression of RDH14 mRNA CTD PMID:22538082 NCBI chr 6:33,156,569...33,161,712
Ensembl chr 6:33,156,569...33,161,712
JBrowse link
G S100a6 S100 calcium binding protein A6 decreases expression ISO Phlorhizin results in decreased expression of S100A6 mRNA CTD PMID:16123366 NCBI chr 2:176,100,619...176,102,181
Ensembl chr 2:176,100,899...176,102,180
JBrowse link
G Sdha succinate dehydrogenase complex flavoprotein subunit A decreases expression ISO Phlorhizin results in decreased expression of SDHA mRNA CTD PMID:22538082 NCBI chr 1:28,935,965...28,960,936
Ensembl chr 1:28,940,164...28,961,535
JBrowse link
G Sdhb succinate dehydrogenase complex iron sulfur subunit B increases expression ISO Phlorhizin results in increased expression of SDHB mRNA CTD PMID:22538082 NCBI chr 5:153,264,906...153,285,570
Ensembl chr 5:153,264,899...153,314,293
JBrowse link
G Sds serine dehydratase decreases expression ISO Phlorhizin results in decreased expression of SDS mRNA CTD PMID:22538082 NCBI chr12:36,083,226...36,090,540
Ensembl chr12:36,083,229...36,088,203
JBrowse link
G Slc2a2 solute carrier family 2 member 2 increases expression ISO Phlorhizin results in increased expression of SLC2A2 mRNA CTD PMID:16123366 NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933
JBrowse link
G Slc35a2 solute carrier family 35 member A2 increases expression ISO Phlorhizin results in increased expression of SLC35A2 mRNA CTD PMID:22538082 NCBI chr  X:14,608,145...14,616,937
Ensembl chr  X:14,608,055...14,616,678
JBrowse link
G Slc5a1 solute carrier family 5 member 1 multiple interactions
decreases activity
affects binding
ISO
EXP
Phlorhizin inhibits the reaction [[Sodium co-treated with SLC5A1 protein] results in increased uptake of methylglucoside]; Phlorhizin inhibits the reaction [SLC5A1 protein results in increased uptake of methylglucoside]
[Phlorhizin results in decreased activity of SLC5A1 protein] which results in decreased uptake of spiraeoside
[Phlorhizin results in decreased activity of SLC5A1 protein] which results in decreased uptake of Glucose
SLC5A1 protein binds to Phlorhizin
CTD PMID:12663055 PMID:12927799 PMID:16300400 PMID:17288452 PMID:17983207 NCBI chr14:77,553,990...77,618,589
Ensembl chr14:77,553,843...77,618,547
JBrowse link
G Slc5a2 solute carrier family 5 member 2 decreases activity ISO Phlorhizin results in decreased activity of SLC5A2 protein CTD PMID:21128592 NCBI chr 1:182,847,185...182,853,309
Ensembl chr 1:182,847,106...182,853,306
JBrowse link
G Sod1 superoxide dismutase 1 increases expression ISO Phlorhizin results in increased expression of SOD1 mRNA CTD PMID:22538082 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 decreases expression ISO Phlorhizin results in decreased expression of SOD2 mRNA CTD PMID:22538082 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Stip1 stress-induced phosphoprotein 1 decreases expression ISO Phlorhizin results in decreased expression of STIP1 mRNA CTD PMID:22538082 NCBI chr 1:204,209,434...204,228,452
Ensembl chr 1:204,178,932...204,228,476
JBrowse link
G Sucla2 succinate-CoA ligase ADP-forming subunit beta decreases expression ISO Phlorhizin results in decreased expression of SUCLA2 mRNA CTD PMID:22538082 NCBI chr15:48,752,356...48,805,495
Ensembl chr15:48,752,312...48,805,138
JBrowse link
G Suclg2 succinate-CoA ligase GDP-forming subunit beta decreases expression ISO Phlorhizin results in decreased expression of SUCLG2 mRNA CTD PMID:22538082 NCBI chr 4:128,067,031...128,337,146
Ensembl chr 4:128,067,033...128,337,170
JBrowse link
G Sugt1 SGT1 homolog, MIS12 kinetochore complex assembly cochaperone decreases expression ISO Phlorhizin results in decreased expression of SUGT1 mRNA CTD PMID:22538082 NCBI chr15:54,991,419...55,032,244
Ensembl chr15:54,990,672...55,069,150
JBrowse link
G Txn1 thioredoxin 1 decreases expression
increases expression
ISO Phlorhizin results in decreased expression of TXN mRNA
Phlorhizin results in increased expression of TXN mRNA
CTD PMID:22538082 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
JBrowse link
G Txn2 thioredoxin 2 increases expression ISO Phlorhizin results in increased expression of TXN2 mRNA CTD PMID:22538082 NCBI chr 7:109,496,772...109,510,378
Ensembl chr 7:109,496,761...109,510,359
JBrowse link
G Ubb ubiquitin B increases expression ISO Phlorhizin results in increased expression of UBB mRNA CTD PMID:22538082 NCBI chr10:47,247,629...47,249,335
Ensembl chr10:47,245,637...47,249,333
JBrowse link
G Ubc ubiquitin C decreases expression ISO Phlorhizin results in decreased expression of UBC mRNA CTD PMID:22538082 NCBI chr12:31,238,889...31,243,924
Ensembl chr12:31,239,152...31,243,925
JBrowse link
G Ube2b ubiquitin-conjugating enzyme E2B decreases expression ISO Phlorhizin results in decreased expression of UBE2B mRNA CTD PMID:22538082 NCBI chr10:36,248,434...36,263,379
Ensembl chr10:36,248,438...36,264,665
JBrowse link
G Ube2f ubiquitin-conjugating enzyme E2F (putative) decreases expression ISO Phlorhizin results in decreased expression of UBE2F mRNA CTD PMID:22538082 NCBI chr 9:91,845,954...91,881,145
Ensembl chr 9:91,845,987...91,880,594
JBrowse link
G Ube2h ubiquitin-conjugating enzyme E2H decreases expression ISO Phlorhizin results in decreased expression of UBE2H mRNA CTD PMID:22538082 NCBI chr 4:58,834,674...58,930,156
Ensembl chr 4:58,834,674...58,930,156
JBrowse link
G Ube2i ubiquitin-conjugating enzyme E2I decreases expression ISO Phlorhizin results in decreased expression of UBE2I mRNA CTD PMID:22538082 NCBI chr10:14,277,749...14,294,681
Ensembl chr10:69,701,618...69,702,443
Ensembl chr10:69,701,618...69,702,443
JBrowse link
G Ube2l3 ubiquitin-conjugating enzyme E2L 3 decreases expression ISO Phlorhizin results in decreased expression of UBE2L3 mRNA CTD PMID:22538082 NCBI chr11:83,797,722...83,838,862
Ensembl chr11:83,797,722...83,838,862
JBrowse link
G Ube2m ubiquitin-conjugating enzyme E2M increases expression ISO Phlorhizin results in increased expression of UBE2M mRNA CTD PMID:22538082 NCBI chr 1:73,662,576...73,666,113
Ensembl chr 1:73,662,576...73,666,026
JBrowse link
G Ube2n ubiquitin-conjugating enzyme E2N decreases expression ISO Phlorhizin results in decreased expression of UBE2N mRNA CTD PMID:22538082 NCBI chr 7:30,154,330...30,184,373
Ensembl chr 7:30,154,616...30,184,355
JBrowse link
G Ube2q1 ubiquitin conjugating enzyme E2 Q1 increases expression ISO Phlorhizin results in increased expression of UBE2Q1 mRNA CTD PMID:22538082 NCBI chr 2:175,198,793...175,209,152
Ensembl chr 2:175,198,873...175,207,942
JBrowse link
G Ube2r2 ubiquitin-conjugating enzyme E2R 2 decreases expression ISO Phlorhizin results in decreased expression of UBE2R2 mRNA CTD PMID:22538082 NCBI chr 5:56,286,604...56,345,160
Ensembl chr 5:56,286,725...56,345,513
JBrowse link
G Ube2v2 ubiquitin conjugating enzyme E2 V2 decreases expression ISO Phlorhizin results in decreased expression of UBE2V2 mRNA CTD PMID:22538082 NCBI chr11:85,304,528...85,338,430
Ensembl chr11:85,304,526...85,336,369
JBrowse link
G Ube4a ubiquitination factor E4A increases expression ISO Phlorhizin results in increased expression of UBE4A mRNA CTD PMID:22538082 NCBI chr 8:45,236,022...45,278,129
Ensembl chr 8:45,236,026...45,278,038
JBrowse link
G Ubr2 ubiquitin protein ligase E3 component n-recognin 2 increases expression ISO Phlorhizin results in increased expression of UBR2 mRNA CTD PMID:22538082 NCBI chr 9:13,982,427...14,062,315
Ensembl chr 9:13,982,329...14,062,139
JBrowse link
G Uchl3 ubiquitin C-terminal hydrolase L3 decreases expression ISO Phlorhizin results in decreased expression of UCHL3 mRNA CTD PMID:22538082 NCBI chr15:78,485,304...78,527,355
Ensembl chr15:78,485,315...78,527,355
JBrowse link
G Uchl5 ubiquitin C-terminal hydrolase L5 decreases expression ISO Phlorhizin results in decreased expression of UCHL5 mRNA CTD PMID:22538082 NCBI chr13:55,520,722...55,556,503
Ensembl chr13:55,520,729...55,556,502
JBrowse link
G Uqcrc2 ubiquinol cytochrome c reductase core protein 2 decreases expression ISO Phlorhizin results in decreased expression of UQCRC2 mRNA CTD PMID:22538082 NCBI chr 1:175,167,933...175,198,499
Ensembl chr 1:175,167,894...175,199,453
JBrowse link
G Usp1 ubiquitin specific peptidase 1 increases expression ISO Phlorhizin results in increased expression of USP1 mRNA CTD PMID:22538082 NCBI chr 5:113,587,564...113,598,934
Ensembl chr 5:113,587,564...113,598,932
JBrowse link
G Usp14 ubiquitin specific peptidase 14 decreases expression ISO Phlorhizin results in decreased expression of USP14 mRNA CTD PMID:22538082 NCBI chr18:1,018,111...1,057,727
Ensembl chr18:1,019,400...1,057,519
JBrowse link
G Usp19 ubiquitin specific peptidase 19 increases expression ISO Phlorhizin results in increased expression of USP19 mRNA CTD PMID:22538082 NCBI chr 8:109,190,727...109,201,761
Ensembl chr 8:109,190,724...109,201,741
JBrowse link
G Usp24 ubiquitin specific peptidase 24 decreases expression ISO Phlorhizin results in decreased expression of USP24 mRNA CTD PMID:22538082 NCBI chr 5:121,080,687...121,210,321
Ensembl chr 5:121,080,470...121,210,311
JBrowse link
G Usp33 ubiquitin specific peptidase 33 decreases expression ISO Phlorhizin results in decreased expression of USP33 mRNA CTD PMID:22538082 NCBI chr 2:241,283,209...241,328,479
Ensembl chr 2:241,292,985...241,328,479
JBrowse link
G Usp4 ubiquitin specific peptidase 4 increases expression ISO Phlorhizin results in increased expression of USP4 mRNA CTD PMID:22538082 NCBI chr 8:109,035,402...109,080,427
Ensembl chr 8:109,036,099...109,080,427
JBrowse link
G Usp45 ubiquitin specific peptidase 45 decreases expression ISO Phlorhizin results in decreased expression of USP45 mRNA CTD PMID:22538082 NCBI chr 5:35,318,621...35,392,090
Ensembl chr 5:35,318,635...35,389,420
JBrowse link
G Usp46 ubiquitin specific peptidase 46 decreases expression ISO Phlorhizin results in decreased expression of USP46 mRNA CTD PMID:22538082 NCBI chr14:34,150,055...34,219,227
Ensembl chr14:34,150,004...34,219,227
JBrowse link
G Usp7 ubiquitin specific peptidase 7 decreases expression ISO Phlorhizin results in decreased expression of USP7 mRNA CTD PMID:22538082 NCBI chr10:6,880,684...6,925,033
Ensembl chr10:6,828,795...6,925,355
JBrowse link
G Usp9x ubiquitin specific peptidase 9, X-linked decreases expression ISO Phlorhizin results in decreased expression of USP9X mRNA CTD PMID:22538082 NCBI chr  X:9,588,825...9,726,993
Ensembl chr  X:9,588,825...9,696,711
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO Phlorhizin results in decreased expression of XIAP mRNA CTD PMID:22538082 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link
trilobatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide affects the localization of BAX protein] CTD PMID:30104959 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein] CTD PMID:30104959 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Cat catalase multiple interactions ISO NFE2L2 protein affects the reaction [trilobatin inhibits the reaction [Isoflurane results in decreased activity of CAT protein]]; trilobatin inhibits the reaction [Isoflurane results in decreased activity of CAT protein] CTD PMID:32663520 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of ESRRA protein] CTD PMID:30104959 NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268
JBrowse link
G Foxo3 forkhead box O3 multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of FOXO3 protein] CTD PMID:30104959 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of GPX1 protein] CTD PMID:30104959 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO
EXP
trilobatin promotes the reaction [Isoflurane results in increased expression of HMOX1 mRNA]; trilobatin promotes the reaction [Isoflurane results in increased expression of HMOX1 protein]
trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of HMOX1 protein]
CTD PMID:30104959 PMID:32663520 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased activity of IDH2 protein]; trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of IDH2 protein] CTD PMID:30104959 NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO trilobatin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; trilobatin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] CTD PMID:25053100 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO trilobatin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; trilobatin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; trilobatin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:25053100 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide results in increased expression of KEAP1 protein] CTD PMID:30104959 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Mt-atp6 mitochondrially encoded ATP synthase membrane subunit 6 multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of ATP6 mRNA] CTD PMID:30104959 Ensembl chr MT:7,919...8,599 JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of COX1 mRNA] CTD PMID:30104959 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
JBrowse link
G Mt-cyb mitochondrially encoded cytochrome b multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of CYTB mRNA] CTD PMID:30104959 NCBI chr MT:14,136...15,278
Ensembl chr MT:14,136...15,278
JBrowse link
G Mt-nd2 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of ND2 mRNA] CTD PMID:30104959 NCBI chr MT:3,904...4,942
Ensembl chr MT:3,904...4,942
JBrowse link
G Mt-nd5 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of ND5 mRNA] CTD PMID:30104959 NCBI chr MT:11,736...13,565
Ensembl chr MT:11,736...13,565
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP
ISO
trilobatin promotes the reaction [Hydrogen Peroxide affects the localization of NFE2L2 protein]
NFE2L2 protein affects the reaction [trilobatin inhibits the reaction [Isoflurane results in decreased activity of CAT protein]]; trilobatin promotes the reaction [Isoflurane results in increased expression of NFE2L2 protein]
CTD PMID:30104959 PMID:32663520 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO trilobatin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein] CTD PMID:25053100 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP
ISO
trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of NQO1 protein]
trilobatin promotes the reaction [Isoflurane results in increased expression of NQO1 mRNA]; trilobatin promotes the reaction [Isoflurane results in increased expression of NQO1 protein]
CTD PMID:30104959 PMID:32663520 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of PPARGC1A protein] CTD PMID:30104959 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO trilobatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] CTD PMID:25053100 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sirt3 sirtuin 3 multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT3 mRNA]; trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT3 protein] CTD PMID:30104959 NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased activity of SOD2 protein]; trilobatin inhibits the reaction [Hydrogen Peroxide results in increased acetylation of SOD2 protein] CTD PMID:30104959 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO trilobatin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; trilobatin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; trilobatin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:25053100 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide results in increased expression of UCP2 protein] CTD PMID:30104959 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      application 19481
        pharmaceutical 19329
          drug 19329
            antineoplastic agent 17317
              phloretin 279
                3-hydroxyphloretin 2'-O-xylosylglucoside 0
                asebogenin 0
                glycyphyllin 0
                phlorizin 232
                trilobatin 25
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      ketone 16923
                                        aromatic ketone 12304
                                          dihydrochalcones 713
                                            dihydrochalcone 279
                                              phloretin 279
                                                3-hydroxyphloretin 2'-O-xylosylglucoside 0
                                                asebogenin 0
                                                glycyphyllin 0
                                                phlorizin 232
                                                trilobatin 25
paths to the root