CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: 2'-deoxyadenosine
Accession: CHEBI:17256
browse the term
Definition: A purine 2'-deoxyribonucleoside having adenine as the nucleobase.
Synonyms: related_synonym: (2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol; 5-(6-AMINO-PURIN-9-YL)-2-HYDROXYMETHYL-TETRAHYDRO-FURAN-3-OL; 9-(2-Deoxy-beta-D-erythro-pentofuranosyl)adenine; 9-(2-deoxy-beta-D-ribofuranosyl)-9H-purin-6-amine; Deoxyadenosine; Formula=C10H13N5O3; InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1; InChIKey=OLXZPDWKRNYJJZ-RRKCRQDMSA-N; SMILES=Nc1ncnc2n(cnc12)[C@H]1C[C@H](O)[C@@H](CO)O1; adenine deoxyribonucleoside; adenyldeoxyriboside; dA
alt_id: CHEBI:14112; CHEBI:19234; CHEBI:39863; CHEBI:40535; CHEBI:40560; CHEBI:4405
xref: Beilstein:91015; CAS:958-09-8; Gmelin:283189; HMDB:HMDB0000101; KEGG:C00559; KNApSAcK:C00019281
xref_mesh: MESH:C058118
xref: MetaCyc:DEOXYADENOSINE; PDBeChem:3D1; PMID:14253484; PMID:18508186; PMID:24144081; PMID:8171392; PMID:9869364; Reaxys:91015; Wikipedia:Deoxyadenosine
G
CDKN1A
cyclin dependent kinase inhibitor 1A
decreases expression
EXP
2'-deoxyadenosine results in decreased expression of CDKN1A mRNA
CTD
PMID:24211769
NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337
G
POLB
DNA polymerase beta
multiple interactions
EXP
[diepoxybutane binds to 2'-deoxyadenosine] which results in decreased activity of POLB protein
CTD
PMID:26098310
NCBI chr 8:42,338,494...42,371,808
Ensembl chr 8:42,338,454...42,371,808
G
POLI
DNA polymerase iota
multiple interactions
EXP
[diepoxybutane binds to 2'-deoxyadenosine] which results in decreased activity of POLI protein; POLN protein inhibits the reaction [[diepoxybutane binds to 2'-deoxyadenosine] which results in decreased activity of POLI protein]
CTD
PMID:26098310
NCBI chr18:54,269,479...54,321,266
Ensembl chr18:54,269,517...54,321,266
G
POLK
DNA polymerase kappa
multiple interactions
EXP
[diepoxybutane binds to 2'-deoxyadenosine] which results in decreased activity of POLK protein
CTD
PMID:26098310
NCBI chr 5:75,510,774...75,609,991
Ensembl chr 5:75,511,845...75,609,991
G
POLN
DNA polymerase nu
multiple interactions
EXP
[diepoxybutane binds to 2'-deoxyadenosine] which results in decreased activity of POLN protein; POLN protein inhibits the reaction [[diepoxybutane binds to 2'-deoxyadenosine] which results in decreased activity of POLI protein]
CTD
PMID:26098310
NCBI chr 4:2,071,918...2,242,121
Ensembl chr 4:2,071,918...2,242,121
G
SLC29A1
solute carrier family 29 member 1 (Augustine blood group)
multiple interactions
ISO
2'-deoxyadenosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]
CTD
PMID:11085929
NCBI chr 6:44,219,615...44,234,142
Ensembl chr 6:44,219,553...44,234,142
G
SLC29A2
solute carrier family 29 member 2
multiple interactions
ISO
2'-deoxyadenosine inhibits the reaction [SLC29A2 protein results in increased uptake of Uridine]
CTD
PMID:11085929
NCBI chr11:66,362,521...66,372,446
Ensembl chr11:66,362,521...66,372,214
G
NEIL1
nei like DNA glycosylase 1
affects metabolic processing
ISO
NEIL1 protein affects the metabolism of 8,5'-cyclo-2'-deoxyadenosine
CTD
PMID:20067321
NCBI chr15:75,347,039...75,357,115
Ensembl chr15:75,346,955...75,357,115
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all