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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4-methylcatechol
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Accession:CHEBI:17254 term browser browse the term
Definition:A methylcatechol having a single methyl substituent at the 4-position. It has been isolated from Picea abies.
Synonyms:related_synonym: 1,2-dihydroxy-4-methylbenzene;   2-Hydroxy-4-methylphenol;   3,4-dihydroxytoluene;   4-Methyl-1,2-dihydroxybenzene;   4-Methylpyrocatechol;   4-methyl-1,2-benzenediol;   4-methylbenzene-1,2-diol;   Formula=C7H8O2;   Homocatechol;   Homopyrocatechol;   InChI=1S/C7H8O2/c1-5-2-3-6(8)7(9)4-5/h2-4,8-9H,1H3;   InChIKey=ZBCATMYQYDCTIZ-UHFFFAOYSA-N;   SMILES=Cc1ccc(O)c(O)c1;   Toluene-3,4-diol;   p-Methylcatechol;   p-Methylpyrocatechol
 alt_id: CHEBI:12025;   CHEBI:1897;   CHEBI:20442;   CHEBI:43962
 xref: CAS:452-86-8;   DrugBank:DB04120;   HMDB:HMDB0000873;   KEGG:C06730;   KNApSAcK:C00002660
 xref_mesh: MESH:C018599
 xref: PDBeChem:MCT;   PMID:18499097;   Reaxys:636512;   UM-BBD_compID:c0126;   Wikipedia:4-Methylcatechol



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4-methylcatechol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Btc betacellulin decreases expression
multiple interactions
EXP 4-methylcatechol results in decreased expression of BTC mRNA
4-methylcatechol results in decreased expression of and results in decreased secretion of BTC protein
CTD PMID:29473434 NCBI chr14:16,708,447...16,746,961
Ensembl chr14:16,707,982...16,747,049
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions ISO 4-methylcatechol inhibits the reaction [resiniferatoxin results in decreased expression of CALCA protein] CTD PMID:18219259 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Comt catechol-O-methyltransferase increases methylation ISO
EXP
COMT protein results in increased methylation of 4-methylcatechol CTD PMID:11160877 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
JBrowse link
G Inhba inhibin subunit beta A decreases expression EXP 4-methylcatechol results in decreased expression of INHBA mRNA CTD PMID:29473434 NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982
JBrowse link
G Ins1 insulin 1 decreases expression
multiple interactions
EXP 4-methylcatechol results in decreased expression of INS1 mRNA
[4-methylcatechol co-treated with Glucose] results in increased secretion of INS1 protein
CTD PMID:29473434 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression ISO 4-methylcatechol results in increased expression of NFE2L2 mRNA CTD PMID:26862668 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Ngf nerve growth factor multiple interactions EXP 4-methylcatechol inhibits the reaction [Streptozocin results in decreased expression of NGF protein] CTD PMID:8195800 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO 4-methylcatechol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; 4-methylcatechol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:18499097 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO 4-methylcatechol inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:18499097 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Slc2a2 solute carrier family 2 member 2 decreases expression EXP 4-methylcatechol results in decreased expression of SLC2A2 mRNA CTD PMID:29473434 NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 4-methylcatechol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; 4-methylcatechol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:18499097 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 multiple interactions ISO 4-methylcatechol inhibits the reaction [resiniferatoxin results in decreased expression of UCHL1 protein] CTD PMID:18219259 NCBI chr14:41,485,031...41,495,590
Ensembl chr14:41,485,031...41,495,590
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19838
    role 19810
      chemical role 19439
        antioxidant 16157
          4-methylcatechol 12
            3-chloro-4-methylcatechol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19838
    subatomic particle 19836
      composite particle 19836
        hadron 19836
          baryon 19836
            nucleon 19836
              atomic nucleus 19836
                atom 19836
                  main group element atom 19782
                    p-block element atom 19782
                      carbon group element atom 19722
                        carbon atom 19719
                          organic molecular entity 19719
                            organic molecule 19670
                              organic cyclic compound 19481
                                organic aromatic compound 19350
                                  phenols 18635
                                    benzenediols 9151
                                      catechols 3404
                                        methylcatechol 13
                                          4-methylcatechol 12
                                            3-chloro-4-methylcatechol 0
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