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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:carbon monoxide
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Accession:CHEBI:17245 term browser browse the term
Definition:A one-carbon compound in which the carbon is joined only to a single oxygen. It is a colourless, odourless, tasteless, toxic gas.
Synonyms:exact_synonym: carbon(II) oxide
 related_synonym: C#O;   CO;   Formula=CO;   InChI=1S/CO/c1-2;   InChIKey=UGFAIRIUMAVXCW-UHFFFAOYSA-N;   SMILES=[C-]#[O+];   carbon monooxide
 alt_id: CHEBI:13281;   CHEBI:23013;   CHEBI:3282;   CHEBI:41526
 xref: Beilstein:1900508;   Beilstein:3535285;   Beilstein:3587264;   CAS:630-08-0;   Gmelin:421;   HMDB:HMDB0001361;   KEGG:C00237;   KEGG:D09706
 xref_mesh: MESH:D002248
 xref: MetaCyc:CARBON-MONOXIDE;   MolBase:753;   PDBeChem:CMO;   PMID:10085152;   PMID:10679539;   PMID:11572959;   PMID:14527438;   PMID:14563665;   PMID:15127883;   PMID:15598489;   PMID:16371440;   PMID:16520836;   PMID:17041734;   PMID:18094356;   PMID:19909254;   PMID:23762709;   PMID:7022476;   PMID:8240252;   PMID:8620577;   UM-BBD_compID:c0369;   Wikipedia:Carbon_monoxide
 cyclic_relationship: is_conjugate_base_of CHEBI:58072


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carbon monoxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 increases activity EXP Carbon Monoxide results in increased activity of ABCC2 protein CTD PMID:13678533 NCBI chr 1:242,664,657...242,723,239 JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions
increases expression
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of NOS3 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased activity of CASP3 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of AKT1 protein; [Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of NOS3 protein
[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased expression of PECAM1 protein; Carbon Monoxide results in increased expression of ADIPOQ protein
CTD PMID:19356108 NCBI chr11:77,721,912...77,735,644 JBrowse link
G Adm adrenomedullin increases expression EXP Carbon Monoxide results in increased expression of ADM mRNA; Carbon Monoxide results in increased expression of ADM protein CTD PMID:10666155 NCBI chr 1:164,745,484...164,747,655 JBrowse link
G Agr2 anterior gradient 2, protein disulphide isomerase family member multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of AGR2 mRNA CTD PMID:29621558 NCBI chr 6:52,708,602...52,729,378 JBrowse link
G Agt angiotensinogen decreases response to substance ISO AGT protein results in decreased susceptibility to Carbon Monoxide CTD PMID:18174886 NCBI chr19:52,529,139...52,549,618 JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO
EXP
AKT1 protein affects the reaction [Carbon Monoxide results in increased localization of NRF1 protein]; Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased phosphorylation of AKT1 protein]; Carbon Monoxide results in increased phosphorylation of and results in increased activity of AKT1 protein; CAT protein inhibits the reaction [Carbon Monoxide results in increased phosphorylation of AKT1 protein]
Carbon Monoxide inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of AKT1 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of AKT1 protein; Carbon Monoxide results in increased phosphorylation of and results in increased activity of AKT1 protein; CAT protein inhibits the reaction [Carbon Monoxide results in increased phosphorylation of and results in increased activity of AKT1 protein]
CTD PMID:17179207 PMID:18037988 PMID:18215737 PMID:18845810 PMID:19356108 NCBI chr 6:131,713,716...131,735,319 JBrowse link
G Alad aminolevulinate dehydratase increases activity
multiple interactions
EXP Carbon Monoxide results in increased activity of ALAD protein
Carbon Monoxide inhibits the reaction [[Phenobarbital co-treated with bromobenzene] results in decreased activity of ALAD protein]
CTD PMID:1032310 PMID:6740708 NCBI chr 5:75,961,993...75,972,334 JBrowse link
G Areg amphiregulin multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in decreased expression of AREG mRNA CTD PMID:29621558 NCBI chr14:16,972,185...16,981,443 JBrowse link
G Bach1 BTB domain and CNC homolog 1 decreases phosphorylation ISO Carbon Monoxide results in decreased phosphorylation of BACH1 protein CTD PMID:18845810 NCBI chr11:26,939,429...26,974,876 JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased phosphorylation of BAD protein] CTD PMID:18037988 NCBI chr 1:204,133,502...204,142,829 JBrowse link
G Bcl2a1 BCL2-related protein A1 multiple interactions ISO BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; MAPK14 protein affects the reaction [BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]] CTD PMID:11880364 NCBI chr 8:89,716,914...89,724,998 JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
decreases expression
EXP Carbon Monoxide results in decreased expression of and results in decreased secretion of BDNF protein
Carbon Monoxide results in decreased expression of BDNF mRNA
CTD PMID:27113706 NCBI chr 3:96,165,042...96,215,621 JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; MAPK14 protein affects the reaction [BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]] CTD PMID:11880364 NCBI chr 8:5,000,844...5,028,470 JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
EXP
ISO
[Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased activity of CASP3 protein]; Carbon Monoxide inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP3 protein]; Carbon Monoxide results in increased cleavage of and results in increased activity of CASP3 protein; Hemin inhibits the reaction [Carbon Monoxide results in increased cleavage of and results in increased activity of CASP3 protein]; tin protoporphyrin IX inhibits the reaction [Hemin inhibits the reaction [Carbon Monoxide results in increased cleavage of and results in increased activity of CASP3 protein]]
[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of CASP3 mRNA
Carbon Monoxide results in increased activity of CASP3 protein
CTD PMID:17173083 PMID:19356108 PMID:19520142 PMID:25562542 PMID:31268311 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Casp7 caspase 7 increases activity EXP Carbon Monoxide results in increased activity of CASP7 protein CTD PMID:25562542 NCBI chr 1:255,437,195...255,476,737 JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions
EXP
ISO
Carbon Monoxide results in increased activity of CASP8 protein
[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of CASP8 mRNA
CTD PMID:25562542 PMID:31268311 NCBI chr 9:60,263,863...60,312,542 JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
EXP
ISO
Carbon Monoxide results in increased activity of CASP9 protein
[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of CASP9 mRNA
CTD PMID:25562542 PMID:31268311 NCBI chr 5:154,108,872...154,126,628 JBrowse link
G Cat catalase multiple interactions ISO
EXP
CAT protein inhibits the reaction [Carbon Monoxide results in increased localization of NFE2L2 protein]; CAT protein inhibits the reaction [Carbon Monoxide results in increased phosphorylation of AKT1 protein]
CAT protein inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]]; CAT protein inhibits the reaction [Carbon Monoxide results in increased phosphorylation of and results in increased activity of AKT1 protein]
CTD PMID:17179207 PMID:18845810 NCBI chr 3:89,842,393...89,874,577 JBrowse link
G Ccl1 C-C motif chemokine ligand 1 multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in decreased expression of CCL1 mRNA CTD PMID:29621558 NCBI chr10:67,128,331...67,131,109 JBrowse link
G Cd86 CD86 molecule decreases expression EXP Carbon Monoxide results in decreased expression of CD86 protein CTD PMID:12201358 NCBI chr11:64,142,193...64,200,816 JBrowse link
G Clca1 chloride channel accessory 1 multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of CLCA1 mRNA CTD PMID:29621558 NCBI chr 2:233,938,677...233,964,369 JBrowse link
G Col11a1 collagen type XI alpha 1 chain multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of COL11A1 mRNA CTD PMID:29621558 NCBI chr 2:201,820,715...202,013,853 JBrowse link
G Crp C-reactive protein increases expression ISO Carbon Monoxide results in increased expression of CRP protein CTD PMID:18629312 NCBI chr13:85,131,635...85,175,179 JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of CXCL11 mRNA CTD PMID:29621558 NCBI chr14:15,689,432...15,692,207 JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP Carbon Monoxide inhibits the reaction [CYP1A1 protein results in increased reduction of sodium chromate(VI)] CTD PMID:1903091 NCBI chr 8:58,096,021...58,102,130 JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO Carbon Monoxide promotes the reaction [1-ethynylpyrene results in increased expression of CYP1B1 mRNA] CTD PMID:10581206 NCBI chr 6:15,342,312...15,350,886 JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions EXP Carbon Monoxide inhibits the reaction [CYP2B1 protein results in increased reduction of sodium chromate(VI)] CTD PMID:1903091 NCBI chr 1:81,518,387...81,544,999 JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity
multiple interactions
ISO
EXP
Carbon Monoxide results in decreased activity of CYP2E1 protein
Carbon Monoxide inhibits the reaction [CYP2E1 protein results in increased reduction of sodium chromate(VI)]
CTD PMID:1903091 PMID:15036350 NCBI chr 1:195,840,330...195,850,728 JBrowse link
G Duox2 dual oxidase 2 increases expression
decreases expression
EXP Carbon Monoxide results in increased expression of DUOX2 mRNA
Carbon Monoxide results in decreased expression of DUOX2 protein
CTD PMID:29223502 NCBI chr 3:109,223,809...109,247,023 JBrowse link
G Edn1 endothelin 1 increases expression
multiple interactions
EXP
ISO
Carbon Monoxide results in increased expression of EDN1 mRNA; Carbon Monoxide results in increased expression of EDN1 protein
Carbon Monoxide deficiency promotes the reaction [HMOX2 mutant form results in increased expression of EDN1 protein]
CTD PMID:11781074 PMID:12969895 PMID:20197249 NCBI chr17:22,454,924...22,460,812 JBrowse link
G Egr1 early growth response 1 multiple interactions ISO Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of EGR1 mRNA]; Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of EGR1 protein]; UCP2 protein promotes the reaction [Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of EGR1 protein]] CTD PMID:22046279 NCBI chr18:26,463,333...26,465,531 JBrowse link
G Epo erythropoietin increases expression EXP Carbon Monoxide results in increased expression of EPO mRNA; Carbon Monoxide results in increased expression of EPO protein CTD PMID:9263988 NCBI chr12:19,204,258...19,207,948 JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha increases expression EXP Carbon Monoxide results in increased expression of ERO1A mRNA CTD PMID:12752442 NCBI chr15:18,495,037...18,530,440 JBrowse link
G Fgb fibrinogen beta chain multiple interactions ISO FGB gene SNP affects the reaction [Carbon Monoxide results in increased expression of IL6 protein] CTD PMID:19750100 NCBI chr 2:168,394,901...168,402,863 JBrowse link
G Foxp3 forkhead box P3 multiple interactions ISO [Air Pollutants results in increased abundance of Carbon Monoxide] which results in increased methylation of FOXP3 promoter CTD PMID:29317916 NCBI chr  X:14,908,494...14,924,994 JBrowse link
G Gabpa GA binding protein transcription factor subunit alpha increases expression
multiple interactions
ISO
EXP
Carbon Monoxide results in increased expression of GABPA mRNA
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of GABPA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of GABPA protein]; Carbon Monoxide promotes the reaction [GABPA protein binds to TFAM promoter]
CTD PMID:17179207 NCBI chr11:23,888,586...23,917,612 JBrowse link
G Gata4 GATA binding protein 4 multiple interactions ISO Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased activity of GATA4 protein] CTD PMID:18037988 NCBI chr15:37,459,601...37,531,291 JBrowse link
G Gpr182 G protein-coupled receptor 182 increases expression EXP Carbon Monoxide results in increased expression of GPR182 mRNA CTD PMID:10666155 NCBI chr 7:63,585,997...63,589,088 JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions ISO Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased expression of GPX4 protein] CTD PMID:18037988 NCBI chr 7:9,650,186...9,652,982 JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
increases phosphorylation
ISO Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased phosphorylation of GSK3B protein]
Carbon Monoxide results in increased phosphorylation of GSK3B protein
CTD PMID:18037988 PMID:18845810 NCBI chr11:62,498,997...62,648,665 JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases chemical synthesis
increases expression
increases activity
ISO
EXP
Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased expression of HMOX1 protein]; Carbon Monoxide inhibits the reaction [IFNG protein results in decreased expression of HMOX1 protein]; HMOX1 protein affects the reaction [Carbon Monoxide results in increased secretion of IL10 protein]; HMOX1 protein promotes the reaction [Carbon Monoxide results in increased expression of IL22 mRNA]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased activity of HMOX1 protein]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased expression of HMOX1 mRNA]
HMOX1 protein results in increased chemical synthesis of Carbon Monoxide
[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein; [RELA protein co-treated with REL protein] inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; MAPK14 protein affects the reaction [BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; MAPK14 protein affects the reaction [BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; RELA protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]
Carbon Monoxide results in increased expression of HMOX1 protein
Edaravone promotes the reaction [Carbon Monoxide results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Carbon Monoxide results in increased activity of HMOX1 protein]; Hemin promotes the reaction [Carbon Monoxide results in increased expression of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [Carbon Monoxide results in increased activity of HMOX1 protein]
CTD PMID:11880364 PMID:16365149 PMID:18037988 PMID:18845810 PMID:19520142 PMID:21444764 PMID:25348283 PMID:29165873 NCBI chr19:13,466,287...13,474,082 JBrowse link
G Hmox2 heme oxygenase 2 multiple interactions
affects chemical synthesis
affects abundance
EXP Carbon Monoxide deficiency promotes the reaction [HMOX2 mutant form results in increased expression of EDN1 protein]
HMOX2 protein affects the chemical synthesis of Carbon Monoxide
HMOX2 protein affects the abundance of Carbon Monoxide
CTD PMID:11342580 PMID:12969895 NCBI chr10:10,797,076...10,831,178 JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP
ISO
[Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]
Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]
CTD PMID:19356108 PMID:19608869 NCBI chr 8:19,553,063...19,565,438 JBrowse link
G Ifng interferon gamma multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in decreased expression of IFNG protein; Carbon Monoxide inhibits the reaction [IFNG protein promotes the reaction [Lipopolysaccharides results in increased expression of IL12B protein]]; Carbon Monoxide inhibits the reaction [IFNG protein results in decreased expression of HMOX1 protein] CTD PMID:16365149 PMID:29621558 NCBI chr 7:53,903,339...53,907,375 JBrowse link
G Il10 interleukin 10 multiple interactions
increases expression
ISO
EXP
Carbon Monoxide promotes the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]; HMOX1 protein affects the reaction [Carbon Monoxide results in increased secretion of IL10 protein]
(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Carbon Monoxide results in increased expression of IL10 protein]; iodopravadoline inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Carbon Monoxide results in increased expression of IL10 protein]]
Carbon Monoxide results in increased expression of IL10 mRNA
CTD PMID:21444764 PMID:31732924 NCBI chr13:42,472,625...42,477,308 JBrowse link
G Il12b interleukin 12B multiple interactions ISO Carbon Monoxide inhibits the reaction [IFNG protein promotes the reaction [Lipopolysaccharides results in increased expression of IL12B protein]] CTD PMID:16365149 NCBI chr10:28,888,832...28,903,796 JBrowse link
G Il13 interleukin 13 multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in decreased expression of IL13 mRNA CTD PMID:29621558 NCBI chr10:37,790,130...37,792,687 JBrowse link
G Il17a interleukin 17A multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of IL17A protein CTD PMID:29621558 NCBI chr 9:23,144,402...23,147,889 JBrowse link
G Il18 interleukin 18 decreases response to substance
multiple interactions
ISO Carbon Monoxide results in decreased susceptibility to IL18 protein
Carbon Monoxide inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein]; Carbon Monoxide inhibits the reaction [IL18 protein results in increased expression of PTEN protein]
CTD PMID:18215737 NCBI chr 8:50,904,630...50,932,887 JBrowse link
G Il1b interleukin 1 beta decreases expression
multiple interactions
increases expression
ISO
EXP
Carbon Monoxide results in decreased expression of IL1B protein
(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone inhibits the reaction [Carbon Monoxide results in increased expression of IL1B protein]; iodopravadoline inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone inhibits the reaction [Carbon Monoxide results in increased expression of IL1B protein]]
CTD PMID:21444764 PMID:31732924 NCBI chr 3:116,577,005...116,583,386 JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 increases expression
multiple interactions
EXP Carbon Monoxide results in increased expression of IL1RL1 protein
(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Carbon Monoxide results in increased expression of IL1RL1 protein]; iodopravadoline inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Carbon Monoxide results in increased expression of IL1RL1 protein]]
CTD PMID:31732924 NCBI chr 9:42,661,694...42,727,266 JBrowse link
G Il33 interleukin 33 multiple interactions
increases expression
EXP (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Carbon Monoxide results in increased expression of IL33 protein]; AM 251 inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Carbon Monoxide results in increased expression of IL33 protein]] CTD PMID:31732924 NCBI chr 1:227,701,964...227,736,374 JBrowse link
G Il4 interleukin 4 decreases expression
multiple interactions
ISO
EXP
Carbon Monoxide results in decreased expression of IL4 protein
[Carbon Monoxide co-treated with (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone] results in increased expression of IL4 protein; iodopravadoline inhibits the reaction [[Carbon Monoxide co-treated with (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone] results in increased expression of IL4 protein]
[Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of IL4 protein
CTD PMID:21444764 PMID:29621558 PMID:31732924 NCBI chr10:37,771,203...37,776,750 JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased secretion of IL6 protein; Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of IL6 protein]; FGB gene SNP affects the reaction [Carbon Monoxide results in increased expression of IL6 protein]; IL6 gene SNP affects the reaction [Carbon Monoxide results in increased expression of IL6 protein] CTD PMID:18629312 PMID:19608869 PMID:19750100 PMID:31268311 NCBI chr 4:5,214,602...5,219,178 JBrowse link
G Irf8 interferon regulatory factor 8 decreases activity ISO Carbon Monoxide results in decreased activity of IRF8 protein CTD PMID:16365149 NCBI chr19:48,790,483...48,812,363 JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO Carbon Monoxide inhibits the reaction [NFE2L2 protein binds to KEAP1 protein] CTD PMID:18845810 NCBI chr 8:19,768,375...19,777,862 JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO MAPK14 protein affects the reaction [BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; MAPK14 protein affects the reaction [BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]] CTD PMID:11880364 NCBI chr20:6,749,646...6,810,590 JBrowse link
G Mir1224 microRNA 1224 multiple interactions ISO [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR1224 mRNA CTD PMID:31268311 NCBI chr11:80,306,902...80,306,986 JBrowse link
G Mir186 microRNA 186 multiple interactions ISO [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR186 mRNA CTD PMID:31268311 NCBI chr 2:246,582,806...246,582,891 JBrowse link
G Mir21 microRNA 21 multiple interactions ISO [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR21 mRNA CTD PMID:31268311 NCBI chr10:71,405,257...71,405,348 JBrowse link
G Mir342 microRNA 342 multiple interactions ISO [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR342 mRNA CTD PMID:31268311 NCBI chr 6:127,565,269...127,565,367 JBrowse link
G Mir374b microRNA 374b multiple interactions ISO [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR374B mRNA CTD PMID:31268311 NCBI chr  X:68,591,732...68,591,799 JBrowse link
G Mir615 microRNA 615 multiple interactions ISO [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR615 mRNA CTD PMID:31268311 NCBI chr 7:134,151,887...134,151,978 JBrowse link
G Mir93 microRNA 93 multiple interactions ISO [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR93 mRNA CTD PMID:31268311 NCBI chr12:17,043,135...17,043,221 JBrowse link
G Mirlet7i microRNA let-7i multiple interactions ISO [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIRLET7I mRNA CTD PMID:31268311 NCBI chr 7:58,642,485...58,642,569 JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression ISO Carbon Monoxide results in increased expression of MMP9 mRNA CTD PMID:20197249 NCBI chr 3:153,684,158...153,692,118 JBrowse link
G Mrc1 mannose receptor, C type 1 multiple interactions EXP [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone co-treated with Carbon Monoxide] results in increased expression of MRC1 protein; iodopravadoline inhibits the reaction [[(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone co-treated with Carbon Monoxide] results in increased expression of MRC1 protein] CTD PMID:31732924 NCBI chr17:77,249,187...77,330,857 JBrowse link
G Ndrg1 N-myc downstream regulated 1 multiple interactions ISO Carbon Monoxide inhibits the reaction [Oxygen deficiency results in increased expression of NDRG1 mRNA]; Carbon Monoxide inhibits the reaction [Oxygen deficiency results in increased expression of NDRG1 protein] CTD PMID:11006124 NCBI chr 7:98,684,487...98,725,869 JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases expression
increases localization
decreases phosphorylation
ISO
EXP
Carbon Monoxide inhibits the reaction [NFE2L2 protein binds to KEAP1 protein]; Carbon Monoxide promotes the reaction [NFE2L2 protein binds to NRF1 promoter]; CAT protein inhibits the reaction [Carbon Monoxide results in increased localization of NFE2L2 protein]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased activity of HMOX1 protein]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased expression of SOD2 mRNA]
Carbon Monoxide results in increased expression of NFE2L2 protein
Edaravone promotes the reaction [Carbon Monoxide results in increased expression of NFE2L2 protein]
Carbon Monoxide results in increased expression of NFE2L2 mRNA
Carbon Monoxide results in decreased phosphorylation of NFE2L2 protein
CTD PMID:18845810 PMID:25348283 NCBI chr 3:60,594,239...60,621,785 JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO [RELA protein co-treated with REL protein] inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; MAPK14 protein affects the reaction [BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; MAPK14 protein affects the reaction [BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; RELA protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]] CTD PMID:11880364 NCBI chr 6:72,858,713...72,861,941 JBrowse link
G Ngf nerve growth factor affects expression
multiple interactions
EXP Carbon Monoxide affects the expression of NGF mRNA
Carbon Monoxide results in decreased expression of and affects the secretion of NGF protein
CTD PMID:27113706 NCBI chr 2:189,901,058...189,954,452 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression
ISO
EXP
Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; PPARG protein promotes the reaction [Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]
Carbon Monoxide results in decreased expression of NOS2 protein
CTD PMID:12201358 PMID:22046279 NCBI chr10:63,815,308...63,851,208 JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of NOS3 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of NOS3 protein CTD PMID:19356108 NCBI chr 4:10,793,834...10,814,170 JBrowse link
G Nppa natriuretic peptide A increases expression EXP Carbon Monoxide results in increased expression of NPPA mRNA CTD PMID:11781074 NCBI chr 5:158,429,042...158,430,351 JBrowse link
G Nrf1 nuclear respiratory factor 1 multiple interactions
increases expression
increases localization
ISO
EXP
AKT1 protein affects the reaction [Carbon Monoxide results in increased localization of NRF1 protein]; Carbon Monoxide promotes the reaction [NFE2L2 protein binds to NRF1 promoter]
Carbon Monoxide results in increased expression of NRF1 protein
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of NRF1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to PPARGC1A protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of NRF1 protein]; Carbon Monoxide promotes the reaction [NRF1 protein binds to PPARGC1A protein]; Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]; CAT protein inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]]
Carbon Monoxide results in increased expression of NRF1 mRNA
CTD PMID:17179207 PMID:18845810 NCBI chr 4:58,664,932...58,772,328 JBrowse link
G Ntf3 neurotrophin 3 decreases expression
multiple interactions
EXP Carbon Monoxide results in decreased expression of NTF3 mRNA
Carbon Monoxide results in decreased expression of and results in decreased secretion of NTF3 protein
CTD PMID:27113706 NCBI chr 4:158,914,984...158,984,453 JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 increases expression EXP [Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased expression of PECAM1 protein CTD PMID:19356108 NCBI chr10:91,590,521...91,652,279 JBrowse link
G Pla2g7 phospholipase A2 group VII affects expression ISO Carbon Monoxide affects the expression of PLA2G7 CTD PMID:21356620 NCBI chr 9:17,362,214...17,404,476 JBrowse link
G Polg DNA polymerase gamma, catalytic subunit increases expression ISO Carbon Monoxide results in increased expression of POLG mRNA; Carbon Monoxide results in increased expression of POLG protein CTD PMID:17179207 NCBI chr 1:133,382,764...133,399,578 JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO [Carbon Monoxide results in increased abundance of Reactive Oxygen Species] which results in increased sumoylation of PPARG protein; Acetylcysteine inhibits the reaction [[Carbon Monoxide results in increased abundance of Reactive Oxygen Species] which results in increased sumoylation of PPARG protein]; PPARG protein promotes the reaction [Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]] CTD PMID:22046279 NCBI chr 4:148,423,102...148,548,471 JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression
multiple interactions
ISO
EXP
Carbon Monoxide results in increased expression of PPARGC1A mRNA
Carbon Monoxide results in increased expression of PPARGC1A protein
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of PPARGC1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to PPARGC1A protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of PPARGC1A protein]; Carbon Monoxide promotes the reaction [NRF1 protein binds to PPARGC1A protein]
CTD PMID:17179207 NCBI chr14:58,860,752...59,516,525 JBrowse link
G Prg2 proteoglycan 2 multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of PRG2 mRNA CTD PMID:29621558 NCBI chr 3:70,062,535...70,066,102 JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO Carbon Monoxide inhibits the reaction [IL18 protein results in increased expression of PTEN protein] CTD PMID:18215737 NCBI chr 1:230,631,303...230,696,754 JBrowse link
G Rel REL proto-oncogene, NF-kB subunit multiple interactions ISO [RELA protein co-treated with REL protein] inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]] CTD PMID:11880364 NCBI chr14:97,690,105...97,721,194 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [RELA protein co-treated with REL protein] inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; RELA protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]] CTD PMID:11880364 NCBI chr 1:202,925,001...202,935,484 JBrowse link
G Selp selectin P increases expression ISO Carbon Monoxide results in increased expression of SELP protein modified form CTD PMID:18629312 NCBI chr13:76,476,229...76,511,846 JBrowse link
G Sod1 superoxide dismutase 1 decreases expression ISO Carbon Monoxide results in decreased expression of SOD1 protein CTD PMID:18629312 NCBI chr11:29,456,673...29,462,249 JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
ISO
EXP
Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased expression of SOD2 protein]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased expression of SOD2 mRNA]
Carbon Monoxide results in increased expression of SOD2 protein
CTD PMID:17179207 PMID:18037988 PMID:18845810 NCBI chr 1:47,638,318...47,645,163 JBrowse link
G Sostdc1 sclerostin domain containing 1 multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of SOSTDC1 mRNA CTD PMID:29621558 NCBI chr 6:53,051,336...53,055,510 JBrowse link
G Tfam transcription factor A, mitochondrial increases expression
multiple interactions
ISO
EXP
Carbon Monoxide results in increased expression of TFAM mRNA; Carbon Monoxide results in increased expression of TFAM protein
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of TFAM protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of TFAM protein]; Carbon Monoxide promotes the reaction [GABPA protein binds to TFAM promoter]; Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]; CAT protein inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]]
CTD PMID:17179207 NCBI chr20:17,356,243...17,368,293 JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
decreases expression
decreases response to substance
EXP
ISO
(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone inhibits the reaction [Carbon Monoxide results in increased expression of TNF protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased activity of CASP3 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Carbon Monoxide inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; iodopravadoline inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone inhibits the reaction [Carbon Monoxide results in increased expression of TNF protein]]
Carbon monoxide decreases expression of Tnf mRNA in reperfused liver nonparenchymal cells
Carbon Monoxide results in decreased susceptibility to TNF protein
[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased secretion of TNF protein; [HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein; [RELA protein co-treated with REL protein] inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of IL6 protein]; Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; MAPK14 protein affects the reaction [BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; MAPK14 protein affects the reaction [BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; RELA protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]
Carbon Monoxide results in decreased expression of TNF protein
CTD PMID:11880364 PMID:17173083 PMID:19356108 PMID:19608869 PMID:21444764 PMID:31268311 PMID:31732924, PMID:18972563 RGD:15023490 NCBI chr20:3,622,011...3,624,629 JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B increases expression ISO Carbon Monoxide results in increased expression of TNFRSF1B protein modified form CTD PMID:18629312 NCBI chr 5:157,070,642...157,104,216 JBrowse link
G Tnfsf4 TNF superfamily member 4 multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of TNFSF4 mRNA CTD PMID:29621558 NCBI chr13:73,723,329...73,746,809 JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions ISO UCP2 protein promotes the reaction [Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of EGR1 protein]]; UCP2 protein promotes the reaction [Carbon Monoxide results in increased abundance of Reactive Oxygen Species] CTD PMID:22046279 NCBI chr 1:154,839,242...154,845,612 JBrowse link
G Vasp vasodilator-stimulated phosphoprotein decreases phosphorylation ISO Carbon Monoxide results in decreased phosphorylation of VASP protein CTD PMID:26582457 NCBI chr 1:78,910,009...78,925,791 JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO
EXP
Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
[Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
CTD PMID:19356108 PMID:19608869 NCBI chr 2:204,038,120...204,057,852 JBrowse link
G Xdh xanthine dehydrogenase increases activity
increases metabolic processing
EXP Carbon Monoxide results in increased activity of XDH protein
Carbon Monoxide results in increased metabolism of XDH protein
CTD PMID:1447108 NCBI chr 6:21,530,463...21,592,172 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19762
    role 19708
      application 19396
        probe 498
          carbon monoxide 97
Path 2
Term Annotations click to browse term
  CHEBI ontology 19762
    subatomic particle 19760
      composite particle 19760
        hadron 19760
          baryon 19760
            nucleon 19760
              atomic nucleus 19760
                atom 19760
                  main group element atom 19651
                    p-block element atom 19651
                      carbon group element atom 19570
                        carbon atom 19560
                          organic molecular entity 19560
                            heteroorganic entity 19203
                              organochalcogen compound 18961
                                organooxygen compound 18894
                                  carbon oxide 115
                                    carbon monoxide 97
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