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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:m-cresol
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Accession:CHEBI:17231 term browser browse the term
Definition:A cresol with the methyl substituent at position 3. It is a minor urinary metabolite of toluene.
Synonyms:related_synonym: 1-hydroxy-3-methylbenzene;   3-Cresol;   3-Hydroxytoluene;   3-methylphenol;   Formula=C7H8O;   InChI=1S/C7H8O/c1-6-3-2-4-7(8)5-6/h2-5,8H,1H3;   InChIKey=RLSSMJSEOOYNOY-UHFFFAOYSA-N;   SMILES=Cc1cccc(O)c1;   m-Kresol;   m-methylphenol;   meta-cresol;   metacresol
 alt_id: CHEBI:11771;   CHEBI:1476;   CHEBI:19988;   CHEBI:41602
 xref: Beilstein:506719;   CAS:108-39-4;   DrugBank:DB01776;   Gmelin:101411;   HMDB:HMDB0002048;   KEGG:C01467;   KEGG:D04951
 xref_mesh: MESH:C042041
 xref: MetaCyc:CPD-112;   PDBeChem:CRS;   PMID:15687000;   PMID:23190556;   Reaxys:506719;   UM-BBD_compID:c0282;   Wikipedia:M-cresol


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m-cresol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn4a sodium voltage-gated channel alpha subunit 4 affects activity ISO 3-cresol affects the activity of SCN4A protein polymorphism CTD PMID:11282107 NCBI chr10:94,505,026...94,557,803
Ensembl chr10:94,505,026...94,557,764
JBrowse link
4-nitro-m-cresol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO 4-nitro-3-cresol results in increased expression of BAX protein
Quercetin inhibits the reaction [4-nitro-3-cresol results in increased expression of BAX protein]
CTD PMID:22467373 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression
ISO Quercetin inhibits the reaction [4-nitro-3-cresol results in decreased expression of BCL2L1 protein] CTD PMID:22467373 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO 4-nitro-3-cresol results in increased activity of CASP3 protein
CASP3 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FAS mRNA]; CASP3 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FAS protein]; CASP3 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FASLG mRNA]; CASP3 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FASLG protein]
Quercetin inhibits the reaction [4-nitro-3-cresol results in increased activity of CASP3 protein]
CTD PMID:22467373 PMID:29307546 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions
ISO 4-nitro-3-cresol results in increased activity of CASP8 protein
CASP8 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FAS mRNA]; CASP8 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FAS protein]; CASP8 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FASLG mRNA]; CASP8 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FASLG protein]
CTD PMID:29307546 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Fas Fas cell surface death receptor increases expression
multiple interactions
ISO 4-nitro-3-cresol results in increased expression of FAS mRNA; 4-nitro-3-cresol results in increased expression of FAS protein
CASP3 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FAS mRNA]; CASP3 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FAS protein]; CASP8 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FAS mRNA]; CASP8 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FAS protein]
CTD PMID:29307546 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand multiple interactions
increases expression
ISO CASP3 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FASLG mRNA]; CASP3 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FASLG protein]; CASP8 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FASLG mRNA]; CASP8 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FASLG protein]
4-nitro-3-cresol results in increased expression of FASL mRNA; 4-nitro-3-cresol results in increased expression of FASL protein
4-nitro-3-cresol results in increased expression of FASLG mRNA; 4-nitro-3-cresol results in increased expression of FASLG protein
CTD PMID:29307546 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 multiple interactions ISO [4-nitro-3-cresol co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of HSD17B4 protein CTD PMID:18336853 NCBI chr18:44,810,462...44,897,677
Ensembl chr18:44,810,388...44,897,640
JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 multiple interactions ISO [4-nitro-3-cresol co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in decreased expression of HSD3B2 protein CTD PMID:18336853 NCBI chr 2:200,712,895...200,722,429
Ensembl chr 2:202,341,422...202,350,929
JBrowse link
G Pla2g3 phospholipase A2, group III decreases expression EXP 4-nitro-3-cresol results in decreased expression of PLA2G3 protein CTD PMID:29292090 NCBI chr14:83,724,828...83,730,614
Ensembl chr14:83,724,933...83,730,614
JBrowse link
fenamiphos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity
multiple interactions
ISO fenamiphos results in decreased activity of ACHE protein
fenamiphos binds to and results in increased phosphorylation of and results in decreased activity of ACHE protein
CTD PMID:17382909 PMID:17402711 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
affects activity
ISO fenamiphos binds to and results in increased activity of NR1I2 protein
fenamiphos affects the activity of NR1I2 protein
CTD PMID:21115097 PMID:23611293 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
fenitrothion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 decreases response to substance ISO ABCC1 protein results in decreased susceptibility to Fenitrothion CTD PMID:12765240 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Ache acetylcholinesterase decreases activity
decreases expression
multiple interactions
ISO
EXP
Fenitrothion results in decreased activity of ACHE protein
Fenitrothion results in decreased expression of ACHE protein
Acetylcysteine inhibits the reaction [Fenitrothion results in decreased activity of ACHE protein]; Acetylcysteine inhibits the reaction [Fenitrothion results in decreased expression of ACHE protein]; Quercetin inhibits the reaction [Fenitrothion results in decreased activity of ACHE protein]
CTD PMID:2086312 PMID:6933967 PMID:30639957 PMID:31173782 PMID:32034696 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Ar androgen receptor multiple interactions
decreases activity
increases expression
affects binding
ISO Dihydrotestosterone inhibits the reaction [Fenitrothion results in increased activity of AR protein]; Fenitrothion analog binds to and results in decreased activity of AR protein; Fenitrothion inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; Fenitrothion inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Fenitrothion inhibits the reaction [Metribolone results in increased activity of AR protein]
Fenitrothion results in decreased activity of AR protein
Fenitrothion results in increased expression of AR mRNA
Fenitrothion binds to AR protein
CTD PMID:11222873 PMID:12676613 PMID:15064155 PMID:15253041 PMID:18324785 PMID:21251949 PMID:21310686 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
EXP Fenitrothion results in increased expression of BAX mRNA; Fenitrothion results in increased expression of BAX protein
Acetylcysteine inhibits the reaction [Fenitrothion results in increased expression of BAX mRNA]; Fenitrothion promotes the reaction [Vehicle Emissions results in increased expression of BAX mRNA]; Plant Preparations inhibits the reaction [Fenitrothion promotes the reaction [Vehicle Emissions results in increased expression of BAX mRNA]]; Plant Preparations inhibits the reaction [Fenitrothion results in increased expression of BAX mRNA]; Plant Preparations inhibits the reaction [Vehicle Emissions promotes the reaction [Fenitrothion results in increased expression of BAX mRNA]]; Quercetin inhibits the reaction [Fenitrothion results in increased expression of BAX mRNA]; Quercetin inhibits the reaction [Fenitrothion results in increased expression of BAX protein]; Vehicle Emissions promotes the reaction [Fenitrothion results in increased expression of BAX mRNA]
CTD PMID:31173782 PMID:32034696 PMID:32572764 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
decreases expression
multiple interactions
ISO
EXP
Fenitrothion results in increased expression of BCL2 mRNA
Fenitrothion results in decreased expression of BCL2 mRNA
Acetylcysteine inhibits the reaction [Fenitrothion results in decreased expression of BCL2 mRNA]; Fenitrothion promotes the reaction [Vehicle Emissions results in decreased expression of BCL2 mRNA]; Plant Preparations inhibits the reaction [Fenitrothion promotes the reaction [Vehicle Emissions results in decreased expression of BCL2 mRNA]]; Plant Preparations inhibits the reaction [Fenitrothion results in decreased expression of BCL2 mRNA]; Plant Preparations inhibits the reaction [Vehicle Emissions promotes the reaction [Fenitrothion results in decreased expression of BCL2 mRNA]]; Vehicle Emissions promotes the reaction [Fenitrothion results in decreased expression of BCL2 mRNA]
CTD PMID:21298709 PMID:31173782 PMID:32572764 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions
EXP Fenitrothion results in increased expression of CASP3 mRNA; Fenitrothion results in increased expression of CASP3 protein
Acetylcysteine inhibits the reaction [Fenitrothion results in increased expression of CASP3 protein]; Fenitrothion promotes the reaction [Vehicle Emissions results in increased expression of CASP3 mRNA]; Plant Preparations inhibits the reaction [Fenitrothion promotes the reaction [Vehicle Emissions results in increased expression of CASP3 mRNA]]; Plant Preparations inhibits the reaction [Fenitrothion results in increased expression of CASP3 mRNA]; Plant Preparations inhibits the reaction [Vehicle Emissions promotes the reaction [Fenitrothion results in increased expression of CASP3 mRNA]]; Quercetin inhibits the reaction [Fenitrothion results in increased expression of CASP3 mRNA]; Quercetin inhibits the reaction [Fenitrothion results in increased expression of CASP3 protein]; Vehicle Emissions promotes the reaction [Fenitrothion results in increased expression of CASP3 mRNA]
CTD PMID:31173782 PMID:32034696 PMID:32572764 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase multiple interactions
increases activity
decreases activity
decreases expression
EXP Fenitrothion promotes the reaction [Potassium Dichromate results in decreased expression of CAT protein]; Plant Extracts inhibits the reaction [Fenitrothion promotes the reaction [Potassium Dichromate results in decreased expression of CAT protein]]; Plant Extracts inhibits the reaction [Fenitrothion results in decreased expression of CAT protein]; Plant Extracts inhibits the reaction [Potassium Dichromate promotes the reaction [Fenitrothion results in decreased expression of CAT protein]]; Plant Preparations inhibits the reaction [Fenitrothion results in decreased activity of CAT protein]; Plant Preparations inhibits the reaction [Vehicle Emissions promotes the reaction [Fenitrothion results in decreased activity of CAT protein]]; Potassium Dichromate promotes the reaction [Fenitrothion results in decreased expression of CAT protein]; Quercetin inhibits the reaction [Fenitrothion results in decreased expression of CAT mRNA]; Quercetin inhibits the reaction [Fenitrothion results in increased activity of CAT protein]; Vehicle Emissions promotes the reaction [Fenitrothion results in decreased activity of CAT protein]
Fenitrothion results in decreased expression of CAT mRNA; Fenitrothion results in decreased expression of CAT protein
CTD PMID:26264430 PMID:30578656 PMID:32034696 PMID:32572764 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cd68 Cd68 molecule increases expression
multiple interactions
EXP Fenitrothion results in increased expression of CD68 protein
[Fenitrothion co-treated with Potassium Dichromate] results in increased expression of CD68 protein; Plant Extracts inhibits the reaction [[Fenitrothion co-treated with Potassium Dichromate] results in increased expression of CD68 protein]; Plant Extracts inhibits the reaction [Fenitrothion results in increased expression of CD68 protein]
CTD PMID:30578656 NCBI chr10:56,268,726...56,270,605
Ensembl chr10:56,268,720...56,270,640
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
multiple interactions
increases expression
ISO
EXP
Fenitrothion results in decreased activity of CYP1A1 protein
Acetylcysteine inhibits the reaction [Fenitrothion results in increased expression of CYP1A1 mRNA]
CTD PMID:15620088 PMID:20183062 PMID:21298709 PMID:30639957 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
decreases activity
ISO Fenitrothion results in increased expression of CYP1A2 mRNA
Fenitrothion results in decreased activity of CYP1A2 protein
CTD PMID:20183062 PMID:22310298 PMID:22634058 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression
decreases activity
multiple interactions
ISO Fenitrothion results in increased expression of CYP2B6 mRNA
Fenitrothion results in decreased activity of CYP2B6 protein
Fenitrothion inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]
CTD PMID:20183062 PMID:22310298 PMID:22634058 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Fenitrothion results in decreased activity of CYP2C8 protein CTD PMID:20183062 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases activity
ISO Fenitrothion inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]
Fenitrothion results in decreased activity of CYP2E1 protein
CTD PMID:22634058 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 decreases activity
increases activity
multiple interactions
increases expression
ISO Fenitrothion results in decreased activity of CYP3A4 protein
Fenitrothion results in increased activity of CYP3A4 protein
[N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with pyrimethanil co-treated with Fenitrothion co-treated with triadimefon co-treated with quinoxyfen co-treated with penconazole] results in increased expression of CYP3A4 mRNA
Fenitrothion results in increased expression of CYP3A4 mRNA
CTD PMID:17293382 PMID:20183062 PMID:22310298 PMID:25028461 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Faah fatty acid amide hydrolase decreases activity ISO Fenitrothion results in decreased activity of FAAH protein CTD PMID:24361246 NCBI chr 5:134,852,899...134,872,095
Ensembl chr 5:134,852,875...134,871,775
JBrowse link
G Faahl fatty-acid amide hydrolase-like decreases activity ISO Fenitrothion results in decreased activity of FAAH protein CTD PMID:24361246 NCBI chr 5:134,330,204...134,349,400
Ensembl chr 5:134,331,929...134,348,995
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions
increases secretion
EXP Fenitrothion promotes the reaction [Potassium Dichromate results in increased secretion of FSHB protein]; Plant Extracts inhibits the reaction [Fenitrothion promotes the reaction [Potassium Dichromate results in increased secretion of FSHB protein]]; Plant Extracts inhibits the reaction [Fenitrothion results in increased secretion of FSHB protein]; Plant Extracts inhibits the reaction [Potassium Dichromate promotes the reaction [Fenitrothion results in increased secretion of FSHB protein]]; Potassium Dichromate promotes the reaction [Fenitrothion results in increased secretion of FSHB protein] CTD PMID:30578656 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions
increases expression
EXP Acetylcysteine inhibits the reaction [Fenitrothion results in increased expression of GFAP protein] CTD PMID:31173782 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
decreases activity
decreases expression
EXP Fenitrothion promotes the reaction [Potassium Dichromate results in decreased expression of GSR protein]; Plant Extracts inhibits the reaction [Fenitrothion promotes the reaction [Potassium Dichromate results in decreased expression of GSR protein]]; Plant Extracts inhibits the reaction [Fenitrothion results in decreased expression of GSR protein]; Plant Extracts inhibits the reaction [Potassium Dichromate promotes the reaction [Fenitrothion results in decreased expression of GSR protein]]; Potassium Dichromate promotes the reaction [Fenitrothion results in decreased expression of GSR protein]
Fenitrothion results in decreased activity of GSR protein
CTD PMID:30578656 PMID:32034696 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gsta4 glutathione S-transferase alpha 4 multiple interactions
decreases expression
EXP Acetylcysteine inhibits the reaction [Fenitrothion results in decreased expression of GSTA4 mRNA] CTD PMID:30639957 NCBI chr 8:85,497,557...85,514,732
Ensembl chr 8:85,497,557...85,518,879
JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 multiple interactions
decreases expression
EXP Quercetin inhibits the reaction [Fenitrothion results in decreased expression of HSD17B3 mRNA] CTD PMID:26264430 NCBI chr17:1,579,319...1,610,745
Ensembl chr17:1,579,319...1,610,745
JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 multiple interactions
decreases expression
EXP Quercetin inhibits the reaction [Fenitrothion results in decreased expression of HSD3B2 mRNA] CTD PMID:26264430 NCBI chr 2:200,712,895...200,722,429
Ensembl chr 2:202,341,422...202,350,929
JBrowse link
G Ifng interferon gamma decreases expression ISO Fenitrothion results in decreased expression of IFNG protein CTD PMID:12108020 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
EXP Acetylcysteine inhibits the reaction [Fenitrothion results in increased expression of IL1B protein] CTD PMID:30639957 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 decreases expression
increases secretion
multiple interactions
ISO
EXP
Fenitrothion results in decreased expression of IL2 protein
Fenitrothion results in increased secretion of IL2 protein
Acetylcysteine inhibits the reaction [Fenitrothion results in increased secretion of IL2 protein]
CTD PMID:12108020 PMID:31173782 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Lcat lecithin cholesterol acyltransferase multiple interactions
decreases activity
ISO Fenitrothion inhibits the reaction [[LCAT protein results in increased metabolism of Lecithins] which results in increased chemical synthesis of Cholesterol Esters]
Fenitrothion results in decreased activity of LCAT protein
CTD PMID:4847537 NCBI chr19:37,913,333...37,916,799
Ensembl chr19:37,913,336...37,916,813
JBrowse link
G Lhb luteinizing hormone subunit beta decreases secretion
multiple interactions
EXP Fenitrothion results in decreased secretion of LHB protein
Quercetin inhibits the reaction [Fenitrothion results in decreased secretion of LHB protein]
CTD PMID:26264430 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Mgll monoglyceride lipase decreases activity ISO Fenitrothion analog results in decreased activity of MGLL protein CTD PMID:16449251 NCBI chr 4:120,671,436...120,773,458
Ensembl chr 4:120,671,489...120,771,088
JBrowse link
G Nceh1 neutral cholesterol ester hydrolase 1 decreases activity ISO Fenitrothion analog results in decreased activity of NCEH1 protein CTD PMID:16449251 NCBI chr 2:112,868,834...112,932,622
Ensembl chr 2:112,868,707...112,934,953
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with pyrimethanil co-treated with Fenitrothion co-treated with triadimefon co-treated with quinoxyfen co-treated with penconazole] results in increased activity of NR1I2 protein CTD PMID:25028461 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 decreases expression
multiple interactions
EXP Fenitrothion results in decreased expression of NR5A1 mRNA
Quercetin inhibits the reaction [Fenitrothion results in decreased expression of NR5A1 mRNA]
CTD PMID:26264430 NCBI chr 3:22,998,900...23,020,441
Ensembl chr 3:22,999,616...23,020,441
JBrowse link
G Pla2g3 phospholipase A2, group III decreases expression EXP Fenitrothion results in decreased expression of PLA2G3 protein CTD PMID:29292090 NCBI chr14:83,724,828...83,730,614
Ensembl chr14:83,724,933...83,730,614
JBrowse link
G Pon1 paraoxonase 1 multiple interactions
decreases expression
decreases activity
EXP Fenitrothion promotes the reaction [Vehicle Emissions results in decreased activity of PON1 protein]; Fenitrothion promotes the reaction [Vehicle Emissions results in decreased expression of PON1 mRNA]; Plant Preparations inhibits the reaction [Fenitrothion promotes the reaction [Vehicle Emissions results in decreased activity of PON1 protein]]; Plant Preparations inhibits the reaction [Fenitrothion promotes the reaction [Vehicle Emissions results in decreased expression of PON1 mRNA]]; Plant Preparations inhibits the reaction [Fenitrothion results in decreased activity of PON1 protein]; Plant Preparations inhibits the reaction [Fenitrothion results in decreased expression of PON1 mRNA]; Plant Preparations inhibits the reaction [Vehicle Emissions promotes the reaction [Fenitrothion results in decreased activity of PON1 protein]]; Plant Preparations inhibits the reaction [Vehicle Emissions promotes the reaction [Fenitrothion results in decreased expression of PON1 mRNA]]; Vehicle Emissions promotes the reaction [Fenitrothion results in decreased activity of PON1 protein]; Vehicle Emissions promotes the reaction [Fenitrothion results in decreased expression of PON1 mRNA] CTD PMID:32572764 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Fenitrothion inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium] CTD PMID:23770354 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO Fenitrothion inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:21561794 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression
multiple interactions
EXP Fenitrothion results in decreased expression of SOD1 mRNA
Quercetin inhibits the reaction [Fenitrothion results in decreased expression of SOD1 mRNA]
CTD PMID:26264430 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
increases expression
EXP Acetylcysteine inhibits the reaction [Fenitrothion results in increased expression of TNF protein]; Acetylcysteine inhibits the reaction [Fenitrothion results in increased secretion of TNF protein] CTD PMID:30639957 PMID:31173782 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
EXP Acetylcysteine inhibits the reaction [Fenitrothion results in increased expression of TP53 mRNA] CTD PMID:31173782 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
fenthion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO
EXP
Fenthion results in decreased activity of ACHE protein CTD PMID:1855619 PMID:14976351 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Ar androgen receptor multiple interactions ISO Dihydrotestosterone inhibits the reaction [Fenthion results in increased activity of AR protein]; Fenthion inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:15064155 PMID:18324785 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bche butyrylcholinesterase decreases activity ISO Fenthion results in decreased activity of BCHE protein CTD PMID:24052565 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 affects metabolic processing ISO CYP3A4 protein affects the metabolism of Fenthion CTD PMID:17110060 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects metabolic processing ISO CYP3A5 protein affects the metabolism of Fenthion CTD PMID:17110060 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases activity ISO Fenthion results in decreased activity of DIO1 protein CTD PMID:29228274 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520
JBrowse link
G Esrrg estrogen-related receptor gamma increases activity ISO Fenthion results in increased activity of ESRRG protein CTD PMID:20143881 NCBI chr13:106,063,799...106,683,353
Ensembl chr13:106,463,368...106,683,436
JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 increases oxidation ISO FMO1 protein results in increased oxidation of Fenthion CTD PMID:14976351 NCBI chr13:80,712,885...80,745,095
Ensembl chr13:80,712,882...80,745,347
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Fenthion results in increased expression of FOS mRNA CTD PMID:21538558 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO Fenthion results in increased expression of GADD45A mRNA CTD PMID:21538558 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 increases expression EXP Fenthion results in increased expression of HSP90AA1 mRNA alternative form CTD PMID:8792849 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO Fenthion results in increased expression of JUN mRNA CTD PMID:21538558 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO Fenthion results in increased expression of MYC mRNA CTD PMID:21538558 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression ISO Fenthion results in increased expression of NR4A1 CTD PMID:21538558 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression ISO Fenthion results in increased expression of PPARG mRNA CTD PMID:32473317 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO Fenthion results in increased expression of PPP1R15A mRNA CTD PMID:21538558 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression ISO Fenthion results in increased expression of SOCS3 mRNA CTD PMID:21538558 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 increases expression ISO Fenthion results in increased expression of TNFAIP3 mRNA CTD PMID:21538558 NCBI chr 1:14,401,103...14,416,369
Ensembl chr 1:14,402,913...14,412,807
JBrowse link
metolcarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Thrb thyroid hormone receptor beta affects binding ISO metolcarb binds to THRB protein CTD PMID:28973306 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19761
    role 19711
      application 19401
        pesticide 16584
          fungicide 10739
            aromatic fungicide 1513
              cresol 113
                m-cresol 60
                  4-(methylsulfanyl)-m-cresol + 19
                  4-nitro-m-cresol + 43
                  amylmetacresol 0
                  metolcarb 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    p-block element atom 19653
                      carbon group element atom 19569
                        carbon atom 19559
                          organic molecular entity 19559
                            organic molecule 19493
                              organic cyclic compound 19318
                                carbocyclic compound 18296
                                  benzenoid aromatic compound 17400
                                    benzenes 17172
                                      toluenes 6249
                                        hydroxytoluene 117
                                          cresol 113
                                            m-cresol 60
                                              4-(methylsulfanyl)-m-cresol + 19
                                              4-nitro-m-cresol + 43
                                              amylmetacresol 0
                                              metolcarb 1
paths to the root