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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:homocysteine
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Accession:CHEBI:17230 term browser browse the term
Definition:A sulfur-containing amino acid consisting of a glycine core with a 2-mercaptoethyl side-chain.
Synonyms:related_synonym: 2-Amino-4-mercaptobutyric acid;   2-amino-4-sulfanylbutanoic acid;   Formula=C4H9NO2S;   Hcy;   InChI=1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7);   InChIKey=FFFHZYDWPBMWHY-UHFFFAOYSA-N;   SMILES=NC(CCS)C(O)=O
 alt_id: CHEBI:14408;   CHEBI:5751
 xref: HMDB:HMDB0000742;   KEGG:C05330
 xref_mesh: MESH:D006710
 xref: PMID:11133260;   PMID:16596805;   PMID:18370634;   Wikipedia:Homocysteine
 cyclic_relationship: is_conjugate_acid_of CHEBI:66952;   is_tautomer_of CHEBI:58065



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homocysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acadm acyl-CoA dehydrogenase medium chain increases expression ISO Homocysteine results in increased expression of ACADM mRNA; Homocysteine results in increased expression of ACADM protein CTD PMID:26993217 NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147
JBrowse link
G Ache acetylcholinesterase increases activity ISO Homocysteine results in increased activity of ACHE protein CTD PMID:16375580 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions
increases expression
ISO [Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of ACTA2 mRNA; [Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of ACTA2 protein; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of ACTA2 mRNA]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of ACTA2 protein]
Homocysteine results in increased expression of ACTA2 mRNA; Homocysteine results in increased expression of ACTA2 protein
CTD PMID:21647593 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Ahcy adenosylhomocysteinase multiple interactions ISO [Arsenic results in increased expression of and results in increased activity of AHCY protein] which results in increased chemical synthesis of Homocysteine CTD PMID:18487201 NCBI chr 3:143,569,134...143,584,359
Ensembl chr 3:143,569,094...143,584,393
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO Atorvastatin inhibits the reaction [Homocysteine results in decreased phosphorylation of AKT1 protein] CTD PMID:20305681 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alb albumin multiple interactions EXP Folic Acid inhibits the reaction [Homocysteine inhibits the reaction [ALB protein binds to Bilirubin]]; Homocysteine inhibits the reaction [ALB protein binds to Bilirubin] CTD PMID:33788065 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Apoa1 apolipoprotein A1 decreases expression
multiple interactions
ISO Homocysteine results in decreased expression of APOA1 mRNA; Homocysteine results in decreased expression of APOA1 protein
Homocysteine inhibits the reaction [Simvastatin results in increased expression of APOA1 mRNA]; Homocysteine inhibits the reaction [Simvastatin results in increased expression of APOA1 protein]
CTD PMID:18540024 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
JBrowse link
G App amyloid beta precursor protein increases abundance ISO APP protein results in increased abundance of Homocysteine CTD PMID:16837103 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Atf1 activating transcription factor 1 multiple interactions EXP Homocysteine promotes the reaction [ATF1 protein binds to CCNA2 promoter] CTD PMID:8550827 NCBI chr 7:131,361,962...131,404,677
Ensembl chr 7:131,362,450...131,404,670
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
affects expression
ISO
EXP
Folic Acid affects the reaction [Homocysteine affects the expression of BAX mRNA]; Folic Acid affects the reaction [Homocysteine affects the expression of BAX protein]; Zeranol inhibits the reaction [Homocysteine results in increased expression of BAX protein]
Homocysteine results in increased expression of BAX mRNA
Folic Acid inhibits the reaction [Homocysteine results in increased expression of BAX mRNA]
Homocysteine affects the expression of BAX mRNA; Homocysteine affects the expression of BAX protein
CTD PMID:16757814 PMID:29250709 PMID:31721048 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bche butyrylcholinesterase multiple interactions
decreases activity
EXP Folic Acid inhibits the reaction [Homocysteine results in decreased activity of BCHE protein] CTD PMID:16442260 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
affects expression
decreases expression
ISO
EXP
Folic Acid affects the reaction [Homocysteine affects the expression of BCL2 mRNA]; Folic Acid affects the reaction [Homocysteine affects the expression of BCL2 protein]; Zeranol inhibits the reaction [Homocysteine results in decreased expression of BCL2 protein]
Homocysteine affects the expression of BCL2 mRNA; Homocysteine affects the expression of BCL2 protein
[Homocysteine co-treated with Sodium Glutamate] affects the expression of BCL2 mRNA; [Homocysteine co-treated with Sodium Glutamate] affects the expression of BCL2 protein; Folic Acid affects the reaction [[Homocysteine co-treated with Sodium Glutamate] affects the expression of BCL2 mRNA]; Folic Acid affects the reaction [[Homocysteine co-treated with Sodium Glutamate] affects the expression of BCL2 protein]
CTD PMID:16757814 PMID:22169520 PMID:29250709 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases expression
multiple interactions
ISO Homocysteine results in decreased expression of BIRC2 mRNA; Homocysteine results in decreased expression of BIRC2 protein
Simvastatin inhibits the reaction [Homocysteine results in decreased expression of BIRC2 mRNA]; Simvastatin inhibits the reaction [Homocysteine results in decreased expression of BIRC2 protein]
CTD PMID:19343037 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression
multiple interactions
ISO Homocysteine results in decreased expression of BIRC3 mRNA; Homocysteine results in decreased expression of BIRC3 protein
Simvastatin inhibits the reaction [Homocysteine results in decreased expression of BIRC3 mRNA]; Simvastatin inhibits the reaction [Homocysteine results in decreased expression of BIRC3 protein]
CTD PMID:19343037 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
JBrowse link
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 affects binding EXP Homocysteine analog binds to CACNA2D1 protein CTD PMID:16380257 NCBI chr 4:18,950,611...19,374,969
Ensembl chr 4:18,951,002...19,374,969
JBrowse link
G Calr calreticulin increases expression ISO Homocysteine results in increased expression of CALR mRNA CTD PMID:26993217 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414
JBrowse link
G Casp1 caspase 1 multiple interactions
increases activity
increases expression
ISO [Folic Acid deficiency results in increased abundance of Homocysteine] promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]; CASP1 protein affects the reaction [Homocysteine promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]]; CASP1 protein affects the reaction [Homocysteine results in decreased secretion of VEGFA protein]; Homocysteine promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]; PYCARD protein affects the reaction [Homocysteine promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]]; PYCARD protein affects the reaction [Homocysteine results in increased activity of CASP1 protein]
Homocysteine results in increased expression of CASP1 mRNA
CTD PMID:22647887 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp3 caspase 3 multiple interactions
affects expression
increases expression
affects cleavage
increases activity
ISO
EXP
Folic Acid affects the reaction [Homocysteine affects the cleavage of CASP3 protein]; Folic Acid affects the reaction [Homocysteine affects the expression of CASP3 mRNA]; mecobalamin inhibits the reaction [Homocysteine results in increased activity of CASP3 protein]; Simvastatin inhibits the reaction [Homocysteine results in increased activity of CASP3 protein]
Homocysteine results in increased expression of CASP3 protein
Folic Acid inhibits the reaction [Homocysteine results in increased expression of CASP3 protein]
Atorvastatin inhibits the reaction [Homocysteine results in increased activity of CASP3 protein]
Homocysteine results in increased expression of CASP3 mRNA; Homocysteine results in increased expression of CASP3 protein
CTD PMID:16715183 PMID:19343037 PMID:20305681 PMID:21237187 PMID:29250709 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions
ISO Homocysteine results in increased activity of CASP7 protein
mecobalamin inhibits the reaction [Homocysteine results in increased activity of CASP7 protein]
CTD PMID:21237187 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 multiple interactions
affects expression
ISO Folic Acid affects the reaction [Homocysteine affects the expression of CASP8 mRNA]; Folic Acid affects the reaction [Homocysteine affects the expression of CASP8 protein]
Homocysteine affects the expression of CASP8 mRNA; Homocysteine affects the expression of CASP8 protein
CTD PMID:29250709 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Cat catalase decreases transport
multiple interactions
decreases expression
ISO CAT protein results in decreased transport of Homocysteine
[CAT gene SNP results in increased susceptibility to [Air Pollutants results in increased abundance of Particulate Matter]] which results in increased abundance of Homocysteine
Homocysteine results in decreased expression of CAT protein
CTD PMID:12631446 PMID:22964297 PMID:30477822 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cbs cystathionine beta synthase affects abundance
multiple interactions
ISO
EXP
CBS protein affects the abundance of Homocysteine; CBS protein affects the abundance of Homocysteine metabolite
Homocysteine inhibits the reaction [Folic Acid results in increased activity of CBS protein]
CTD PMID:19204075 PMID:23024785 PMID:31721048 NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression
ISO [Homocysteine results in increased expression of CCL2 protein] which results in increased phosphorylation of NFKBIA protein; [Homocysteine results in increased expression of CCL2 protein] which results in increased reduction of NFKBIA mRNA; acetovanillone inhibits the reaction [Homocysteine results in increased expression of CCL2 mRNA]; Folic Acid inhibits the reaction [Homocysteine results in increased expression of CCL2 mRNA]
Homocysteine results in increased expression of CCL2 mRNA; Homocysteine results in increased expression of CCL2 protein
CTD PMID:11356643 PMID:16845898 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions
increases expression
ISO [Homocysteine co-treated with Lipopolysaccharides] results in increased secretion of CCL5 protein
Homocysteine results in increased expression of CCL5 mRNA
CTD PMID:16225753 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccn4 cellular communication network factor 4 decreases expression ISO Homocysteine results in decreased expression of CCN4 mRNA CTD PMID:17320366 NCBI chr 7:98,645,238...98,677,253
Ensembl chr 7:98,645,182...98,677,248
JBrowse link
G Ccna1 cyclin A1 multiple interactions
decreases methylation
decreases expression
ISO DNMT1 protein affects the reaction [Homocysteine results in decreased expression of CCNA1 mRNA]; Homocysteine inhibits the reaction [MECP2 protein binds to CCNA1 promoter]; Homocysteine promotes the reaction [H3-4 protein modified form binds to CCNA1 promoter]; Homocysteine promotes the reaction [H4-16 protein modified form binds to CCNA1 promoter]
Homocysteine results in decreased methylation of CCNA1 promoter
CTD PMID:17698632 NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157
JBrowse link
G Ccna2 cyclin A2 multiple interactions
increases expression
EXP Dactinomycin inhibits the reaction [Homocysteine results in increased expression of CCNA2 mRNA]; Homocysteine promotes the reaction [ATF1 protein binds to CCNA2 promoter]
Homocysteine results in increased expression of CCNA2 mRNA; Homocysteine results in increased expression of CCNA2 protein
CTD PMID:8550827 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Cdh3 cadherin 3 multiple interactions
decreases expression
ISO [Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of CDH3 mRNA; [Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of CDH3 protein; acetovanillone inhibits the reaction [Homocysteine results in decreased expression of CDH3 protein]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of CDH3 mRNA]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of CDH3 protein]; CYBB mutant form inhibits the reaction [Homocysteine results in decreased expression of CDH3 protein]
Homocysteine results in decreased expression of CDH3 mRNA; Homocysteine results in decreased expression of CDH3 protein
CTD PMID:21647593 NCBI chr19:34,393,596...34,444,084
Ensembl chr19:34,393,727...34,444,084
JBrowse link
G Comt catechol-O-methyltransferase multiple interactions ISO [tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of Homocysteine] CTD PMID:16758261 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
JBrowse link
G Cox5b cytochrome c oxidase subunit 5B multiple interactions ISO [Methionine deficiency co-treated with Homocysteine] affects the expression of COX5B protein CTD PMID:17116298 NCBI chr 9:38,921,980...38,923,806
Ensembl chr 9:38,921,967...38,925,052
JBrowse link
G Crk CRK proto-oncogene, adaptor protein multiple interactions ISO [Methionine deficiency co-treated with Homocysteine] affects the expression of CRK protein CTD PMID:17116298 NCBI chr10:60,530,469...60,556,703
Ensembl chr10:60,530,464...60,553,406
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions
increases expression
affects localization
ISO CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of CDH3 mRNA]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of CDH3 protein]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of TJP1 mRNA]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of ACTA2 mRNA]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of ACTA2 protein]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of S100A4 mRNA]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of S100A4 protein]; CYBB mutant form inhibits the reaction [Homocysteine results in decreased expression of CDH3 protein]; CYBB mutant form inhibits the reaction [Homocysteine results in decreased expression of TJP1 protein]; CYBB mutant form inhibits the reaction [Homocysteine results in increased abundance of Superoxides]; CYBB mutant form inhibits the reaction [Homocysteine results in increased expression of S100A4 protein]; CYBB protein affects the reaction [Homocysteine results in decreased secretion of VEGFA protein]; CYBB protein affects the reaction [Homocysteine results in increased abundance of Superoxides]; CYBB protein mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of NPHS1 mRNA]; CYBB protein mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of NPHS2 mRNA]; CYBB protein mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of DES mRNA]; Filipin inhibits the reaction [Homocysteine affects the localization of CYBB protein]; methyl-beta-cyclodextrin inhibits the reaction [Homocysteine affects the localization of CYBB protein]
Homocysteine results in increased expression of CYBB mRNA; Homocysteine results in increased expression of CYBB protein
CTD PMID:20036696 PMID:20116427 PMID:21647593 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Ddc dopa decarboxylase multiple interactions ISO [Levodopa co-treated with DDC] results in decreased abundance of Homocysteine CTD PMID:11445284 NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO Glycine inhibits the reaction [Homocysteine results in increased expression of DDIT3 mRNA]; Glycine inhibits the reaction [Homocysteine results in increased expression of DDIT3 protein]
Homocysteine results in increased expression of DDIT3 mRNA; Homocysteine results in increased expression of DDIT3 protein
CTD PMID:27064126 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Des desmin multiple interactions
increases expression
ISO [Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of DES mRNA; acetovanillone inhibits the reaction [Homocysteine results in increased expression of DES mRNA]; acetovanillone inhibits the reaction [Homocysteine results in increased expression of DES protein]; Amitriptyline inhibits the reaction [Homocysteine results in increased expression of DES protein]; CYBB protein mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of DES mRNA]; diphenyleneiodonium inhibits the reaction [Homocysteine results in increased expression of DES mRNA]; diphenyleneiodonium inhibits the reaction [Homocysteine results in increased expression of DES protein]; Filipin inhibits the reaction [Homocysteine results in increased expression of DES mRNA]; Filipin inhibits the reaction [Homocysteine results in increased expression of DES protein]; methyl-beta-cyclodextrin inhibits the reaction [Homocysteine results in increased expression of DES mRNA]; methyl-beta-cyclodextrin inhibits the reaction [Homocysteine results in increased expression of DES protein]
Homocysteine results in increased expression of DES mRNA; Homocysteine results in increased expression of DES protein
CTD PMID:20036696 PMID:20116427 PMID:23024785 NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699
JBrowse link
G Dnm1l dynamin 1-like multiple interactions ISO Homocysteine results in increased expression of and results in increased phosphorylation of DNM1L protein; xestospongin C inhibits the reaction [Homocysteine results in increased expression of and results in increased phosphorylation of DNM1L protein] CTD PMID:33751715 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases activity
multiple interactions
ISO Homocysteine results in decreased activity of DNMT1 protein
DNMT1 protein affects the reaction [Homocysteine results in decreased expression of CCNA1 mRNA]
CTD PMID:17698632 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
JBrowse link
G Edn1 endothelin 1 multiple interactions
affects expression
ISO Zeranol inhibits the reaction [Homocysteine affects the expression of EDN1 protein] CTD PMID:16757814 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 decreases phosphorylation ISO Homocysteine results in decreased phosphorylation of EIF2AK3 protein CTD PMID:22964297 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation ISO Homocysteine results in increased phosphorylation of EIF2S1 protein CTD PMID:22964297 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Ephb6 Eph receptor B6 decreases expression ISO Homocysteine results in decreased expression of EPHB6 mRNA CTD PMID:17320366 NCBI chr 4:70,491,973...70,507,230
Ensembl chr 4:70,491,973...70,507,230
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 decreases phosphorylation ISO Homocysteine results in decreased phosphorylation of ERN1 protein CTD PMID:22964297 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha decreases expression ISO Homocysteine results in decreased expression of ERO1A protein CTD PMID:22964297 NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478
JBrowse link
G Exosc4 exosome component 4 multiple interactions ISO [Methionine deficiency co-treated with Homocysteine] affects the expression of EXOSC4 protein CTD PMID:17116298 NCBI chr 7:108,047,831...108,050,573
Ensembl chr 7:108,047,831...108,050,573
JBrowse link
G Gata4 GATA binding protein 4 decreases expression
multiple interactions
EXP Homocysteine results in decreased expression of GATA4 mRNA; Homocysteine results in decreased expression of GATA4 protein
Particulate Matter promotes the reaction [Homocysteine results in decreased expression of GATA4 protein]
CTD PMID:27203204 NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636
JBrowse link
G Gh1 growth hormone 1 decreases abundance ISO GH1 protein results in decreased abundance of Homocysteine CTD PMID:17311540 PMID:17324600 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078
JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity
multiple interactions
EXP Homocysteine results in increased activity of GPT protein
Folic Acid inhibits the reaction [Homocysteine results in increased activity of GPT protein]
CTD PMID:33788065 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases activity
decreases expression
ISO Homocysteine results in decreased activity of GPX1 protein
Homocysteine results in decreased expression of GPX1 protein
CTD PMID:15734734 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 increases expression EXP Homocysteine analog results in increased expression of GRIN1 protein CTD PMID:20406136 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
JBrowse link
G Gsr glutathione-disulfide reductase decreases expression ISO Homocysteine results in decreased expression of GSR protein CTD PMID:22964297 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 multiple interactions ISO [Methionine deficiency co-treated with Homocysteine] affects the expression of GSTM3 protein CTD PMID:17116298 NCBI chr 2:195,531,627...195,534,562
Ensembl chr 2:195,531,495...195,534,553
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO [GSTP1 gene SNP results in increased susceptibility to [Air Pollutants results in increased abundance of Particulate Matter]] which results in increased abundance of Homocysteine CTD PMID:30477822 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G H3f4 H3.4 histone multiple interactions ISO Homocysteine promotes the reaction [H3-4 protein modified form binds to CCNA1 promoter] CTD PMID:17698632 NCBI chr10:43,740,797...43,741,207 JBrowse link
G H4f16 H4 histone 16 multiple interactions ISO Homocysteine promotes the reaction [H4-16 protein modified form binds to CCNA1 promoter] CTD PMID:17698632
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression
ISO Glycine inhibits the reaction [Homocysteine results in increased expression of HSPA5 mRNA]
Homocysteine results in increased expression of HSPA5 mRNA; Homocysteine results in increased expression of HSPA5 protein
CTD PMID:19960509 PMID:27064126 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 multiple interactions ISO Homocysteine promotes the reaction [HSPA9 protein binds to ITPR1 protein]; Homocysteine promotes the reaction [HSPA9 protein binds to VDAC1 protein] CTD PMID:33751715 NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292
JBrowse link
G Isl1 ISL LIM homeobox 1 affects expression
multiple interactions
ISO Homocysteine affects the expression of ISL1 mRNA
Folic Acid inhibits the reaction [Homocysteine affects the expression of ISL1 mRNA]; Inositol promotes the reaction [Folic Acid inhibits the reaction [Homocysteine affects the expression of ISL1 mRNA]]
CTD PMID:19638421 NCBI chr 2:48,079,412...48,090,704
Ensembl chr 2:48,080,522...48,095,584
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 increases expression
multiple interactions
ISO Homocysteine results in increased expression of ITPR1 protein
Homocysteine promotes the reaction [HSPA9 protein binds to ITPR1 protein]
CTD PMID:33751715 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 increases expression ISO Homocysteine results in increased expression of KEAP1 protein CTD PMID:22964297 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; [1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester co-treated with Genistein] inhibits the reaction [Thapsigargin promotes the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]]; Acetylcysteine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Folic Acid inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; fulvic acid inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Genistein inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Genistein inhibits the reaction [Thapsigargin promotes the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]]; Go 6976 inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Pertussis Toxin inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Phorbol 12,13-Dibutyrate inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Phorbol 12,13-Dibutyrate promotes the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Staurosporine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Tetradecanoylphorbol Acetate promotes the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Thapsigargin promotes the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]
6-Cyano-7-nitroquinoxaline-2,3-dione inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; 6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; alpha-methyl-4-carboxyphenylglycine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Cystine affects the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Dizocilpine Maleate inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]
CTD PMID:16251475 PMID:19850060 PMID:25888188 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions
increases phosphorylation
ISO Acetylcysteine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK14 protein]; Atorvastatin inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK14 protein]; diphenyleneiodonium inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK14 protein]; NOX4 mutant form inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK14 protein]; SB 203580 inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK14 protein] CTD PMID:19767766 PMID:20018284 PMID:20305681 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; [1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester co-treated with Genistein] inhibits the reaction [Thapsigargin promotes the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]]; Acetylcysteine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Folic Acid inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; fulvic acid inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Genistein inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Genistein inhibits the reaction [Thapsigargin promotes the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]]; Go 6976 inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Pertussis Toxin inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Phorbol 12,13-Dibutyrate inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Phorbol 12,13-Dibutyrate promotes the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Staurosporine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Tetradecanoylphorbol Acetate promotes the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Thapsigargin promotes the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]
6-Cyano-7-nitroquinoxaline-2,3-dione inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; 6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; alpha-methyl-4-carboxyphenylglycine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Cystine affects the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Dizocilpine Maleate inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]
CTD PMID:16251475 PMID:19850060 PMID:25888188 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions
ISO Homocysteine results in increased phosphorylation of MAPK8 protein
fulvic acid inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK8 protein]
CTD PMID:25888188 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation
multiple interactions
ISO Homocysteine results in increased phosphorylation of MAPK9 protein
fulvic acid inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK9 protein]
CTD PMID:25888188 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mcu mitochondrial calcium uniporter increases expression ISO Homocysteine results in increased expression of MCU protein CTD PMID:33751715 NCBI chr20:27,417,529...27,580,110
Ensembl chr20:27,417,526...27,580,110
JBrowse link
G Mecp2 methyl CpG binding protein 2 multiple interactions ISO Homocysteine inhibits the reaction [MECP2 protein binds to CCNA1 promoter] CTD PMID:17698632 NCBI chr  X:151,781,177...151,844,687
Ensembl chr  X:151,789,930...151,844,689
JBrowse link
G Mfn2 mitofusin 2 decreases expression ISO Homocysteine results in decreased expression of MFN2 protein CTD PMID:33751715 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions EXP Dizocilpine Maleate inhibits the reaction [Homocysteine analog results in decreased expression of and results in decreased activity of MMP1 protein]; Homocysteine analog results in decreased expression of and results in decreased activity of MMP1 protein CTD PMID:20406136 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
increases expression
increases activity
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Homocysteine results in increased activity of MMP9 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Homocysteine results in increased expression of MMP9 protein]; Acetylcysteine inhibits the reaction [Homocysteine results in increased activity of MMP9 protein]; Acetylcysteine inhibits the reaction [Homocysteine results in increased expression of MMP9 protein]; Staurosporine inhibits the reaction [Homocysteine results in increased activity of MMP9 protein]; Staurosporine inhibits the reaction [Homocysteine results in increased expression of MMP9 protein]
Dizocilpine Maleate inhibits the reaction [Homocysteine analog results in decreased expression of MMP9 protein]
Homocysteine results in increased activity of and results in increased expression of MMP9 protein
CTD PMID:16251475 PMID:20406136 PMID:22326992 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mt1 metallothionein 1 multiple interactions
decreases expression
EXP [Folic Acid co-treated with Zinc] inhibits the reaction [Homocysteine results in decreased expression of MT1A mRNA]; Folic Acid inhibits the reaction [Homocysteine results in decreased expression of MT1A mRNA]; Zinc inhibits the reaction [Homocysteine results in decreased expression of MT1A mRNA] CTD PMID:19641857 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
JBrowse link
G Mthfr methylenetetrahydrofolate reductase increases expression
multiple interactions
affects abundance
decreases methylation
increases abundance
affects metabolic processing
ISO Homocysteine results in increased expression of MTHFR protein
[MTHFR gene mutant form co-treated with Methotrexate] results in increased abundance of Homocysteine
MTHFR protein affects the abundance of Homocysteine metabolite
Homocysteine inhibits the reaction [Simvastatin results in increased expression of MTHFR protein modified form]; Simvastatin promotes the reaction [Homocysteine results in increased expression of MTHFR protein]
MTHFR protein SNP results in decreased methylation of Homocysteine
MTHFR gene polymorphism results in increased abundance of Homocysteine; MTHFR protein mutant form results in increased abundance of Homocysteine
MTHFR protein affects the metabolism of Homocysteine
CTD PMID:7647779 PMID:17387702 PMID:18540024 PMID:19204075 PMID:19593106 More... NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797
JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase affects metabolic processing
multiple interactions
affects binding
ISO
EXP
MTR gene polymorphism affects the metabolism of Homocysteine
Homocysteine inhibits the reaction [Folic Acid results in increased activity of MTR protein]
Homocysteine binds to MTR protein
CTD PMID:17477549 PMID:20532609 PMID:31721048 NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822
JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase affects abundance ISO MTRR protein affects the abundance of Homocysteine CTD PMID:17369066 NCBI chr 1:34,866,991...34,899,425
Ensembl chr 1:34,867,089...34,899,425
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 affects localization
increases phosphorylation
multiple interactions
ISO Homocysteine affects the localization of NCF1 protein
Homocysteine results in increased phosphorylation of NCF1 protein
Filipin inhibits the reaction [Homocysteine affects the localization of NCF1 protein]; methyl-beta-cyclodextrin inhibits the reaction [Homocysteine affects the localization of NCF1 protein]
Folic Acid inhibits the reaction [Homocysteine results in increased phosphorylation of NCF1 protein]; Homocysteine promotes the reaction [NCF1 protein results in increased abundance of Reactive Oxygen Species]; Homocysteine results in increased localization of and results in increased activity of NCF1 protein
CTD PMID:16845898 PMID:17586618 PMID:20036696 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects localization
multiple interactions
increases expression
ISO Homocysteine affects the localization of NFE2L2 protein modified form
acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Homocysteine results in decreased expression of NFE2L2 protein]; Homocysteine results in decreased phosphorylation of and results in decreased expression of NFE2L2 protein; L 709049 inhibits the reaction [Homocysteine results in decreased expression of NFE2L2 protein]; N-(4-fluorophenylsulfonyl)-L-valyl-L-leucinal inhibits the reaction [Homocysteine results in decreased phosphorylation of and results in decreased expression of NFE2L2 protein]
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Homocysteine results in decreased phosphorylation of and results in decreased expression of NFE2L2 protein]; Homocysteine results in decreased phosphorylation of and results in decreased expression of NFE2L2 protein
Homocysteine results in increased expression of NFE2L2 mRNA
CTD PMID:22964297 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
increases degradation
ISO [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; [Adenosine co-treated with Homocysteine] results in decreased expression of NFKBIA mRNA; [Homocysteine results in increased expression of CCL2 protein] which results in increased phosphorylation of NFKBIA protein; [Homocysteine results in increased expression of CCL2 protein] which results in increased reduction of NFKBIA mRNA; acetovanillone inhibits the reaction [Homocysteine results in increased phosphorylation of and results in increased activity of NFKBIA protein]; Folic Acid inhibits the reaction [Homocysteine results in increased phosphorylation of and results in increased activity of NFKBIA protein]; Homocysteine results in increased phosphorylation of and results in increased activity of NFKBIA protein
Homocysteine results in increased degradation of NFKBIA protein
CTD PMID:11356643 PMID:16845898 PMID:17586618 PMID:24224954 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nfkbib NFKB inhibitor beta increases degradation ISO Homocysteine results in increased degradation of NFKBIB protein CTD PMID:17586618 NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862
JBrowse link
G Nkx2-5 NK2 homeobox 5 multiple interactions
decreases expression
EXP Particulate Matter promotes the reaction [Homocysteine results in decreased expression of NKX2-5 protein]
Homocysteine results in decreased expression of NKX2-5 mRNA; Homocysteine results in decreased expression of NKX2-5 protein
CTD PMID:27203204 NCBI chr10:16,340,428...16,347,004
Ensembl chr10:16,344,159...16,346,934
JBrowse link
G Nlrc3 NLR family, CARD domain containing 3 multiple interactions
increases expression
ISO [Folic Acid deficiency results in increased abundance of Homocysteine] promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]; CASP1 protein affects the reaction [Homocysteine promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]]; Homocysteine promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]; PYCARD protein affects the reaction [Homocysteine promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]]
Homocysteine results in increased expression of NLRC3 mRNA
CTD PMID:22647887 NCBI chr10:11,551,378...11,585,027
Ensembl chr10:11,551,356...11,584,398
JBrowse link
G Nos2 nitric oxide synthase 2 increases methylation
increases expression
multiple interactions
ISO Homocysteine results in increased methylation of NOS2 promoter
Homocysteine results in increased expression of NOS2 mRNA
Homocysteine affects the reaction [Simvastatin results in increased expression of NOS2 protein]; Simvastatin promotes the reaction [Homocysteine results in increased expression of NOS2 mRNA]
[Homocysteine results in increased methylation of NOS2 promoter] which results in decreased expression of NOS2 mRNA; Clofibrate inhibits the reaction [Homocysteine results in increased methylation of NOS2 promoter]; pioglitazone inhibits the reaction [Homocysteine results in increased methylation of NOS2 promoter]
CTD PMID:17492134 PMID:18540024 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
decreases expression
decreases phosphorylation
ISO Folic Acid inhibits the reaction [Homocysteine results in decreased expression of and results in decreased activity of NOS3 protein]; Homocysteine results in decreased expression of and results in decreased activity of NOS3 protein; Zeranol inhibits the reaction [Homocysteine results in decreased expression of NOS3 protein]
Homocysteine results in decreased expression of NOS3 mRNA; Homocysteine results in decreased expression of NOS3 protein
Homocysteine results in decreased phosphorylation of NOS3 protein
Atorvastatin inhibits the reaction [Homocysteine results in decreased expression of NOS3 mRNA]; Atorvastatin inhibits the reaction [Homocysteine results in decreased phosphorylation of NOS3 protein]
CTD PMID:16757814 PMID:17357445 PMID:20305681 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions
increases response to substance
increases expression
ISO Atorvastatin inhibits the reaction [Homocysteine results in increased expression of NOX4 mRNA]; NOX4 mutant form inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK14 protein]
NOX4 results in increased susceptibility to Homocysteine
CTD PMID:20018284 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin decreases expression
multiple interactions
ISO Homocysteine results in decreased expression of NPHS1 mRNA; Homocysteine results in decreased expression of NPHS1 protein
[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of NPHS1 mRNA; acetovanillone inhibits the reaction [Homocysteine results in decreased expression of NPHS1 mRNA]; acetovanillone inhibits the reaction [Homocysteine results in decreased expression of NPHS1 protein]; CYBB protein mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of NPHS1 mRNA]; diphenyleneiodonium inhibits the reaction [Homocysteine results in decreased expression of NPHS1 mRNA]; diphenyleneiodonium inhibits the reaction [Homocysteine results in decreased expression of NPHS1 protein]; Filipin inhibits the reaction [Homocysteine results in decreased expression of NPHS1 mRNA]; Filipin inhibits the reaction [Homocysteine results in decreased expression of NPHS1 protein]; methyl-beta-cyclodextrin inhibits the reaction [Homocysteine results in decreased expression of NPHS1 mRNA]; methyl-beta-cyclodextrin inhibits the reaction [Homocysteine results in decreased expression of NPHS1 protein]
CTD PMID:20036696 PMID:20116427 NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078
JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin multiple interactions
decreases expression
ISO [Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of NPHS2 mRNA; acetovanillone inhibits the reaction [Homocysteine results in decreased expression of NPHS2 mRNA]; acetovanillone inhibits the reaction [Homocysteine results in decreased expression of NPHS2 protein]; Amitriptyline inhibits the reaction [Homocysteine results in decreased expression of NPHS2 protein]; CYBB protein mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of NPHS2 mRNA]; diphenyleneiodonium inhibits the reaction [Homocysteine results in decreased expression of NPHS2 mRNA]; diphenyleneiodonium inhibits the reaction [Homocysteine results in decreased expression of NPHS2 protein]; Filipin inhibits the reaction [Homocysteine results in decreased expression of NPHS2 mRNA]; Filipin inhibits the reaction [Homocysteine results in decreased expression of NPHS2 protein]; methyl-beta-cyclodextrin inhibits the reaction [Homocysteine results in decreased expression of NPHS2 mRNA]; methyl-beta-cyclodextrin inhibits the reaction [Homocysteine results in decreased expression of NPHS2 protein]
Homocysteine results in decreased expression of NPHS2 mRNA; Homocysteine results in decreased expression of NPHS2 protein
CTD PMID:20036696 PMID:20116427 PMID:23024785 NCBI chr13:68,448,720...68,461,312
Ensembl chr13:68,448,926...68,461,313
JBrowse link
G Nt5e 5' nucleotidase, ecto affects activity ISO Homocysteine affects the activity of NT5E protein CTD PMID:24055814 NCBI chr 8:89,271,046...89,314,918
Ensembl chr 8:89,270,696...89,314,881
JBrowse link
G Pacs2 phosphofurin acidic cluster sorting protein 2 increases expression ISO Homocysteine results in increased expression of PACS2 protein CTD PMID:33751715 NCBI chr 6:132,096,992...132,156,702
Ensembl chr 6:132,096,901...132,154,583
JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO [Methionine results in increased abundance of Homocysteine] which results in decreased activity of PON1 protein; [resveratrol results in increased abundance of Homocysteine] which results in decreased activity of PON1 protein CTD PMID:19028542 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Prdx6 peroxiredoxin 6 multiple interactions ISO [Methionine deficiency co-treated with Homocysteine] affects the expression of PRDX6 protein CTD PMID:17116298 NCBI chr13:73,528,746...73,539,295
Ensembl chr13:73,528,210...73,539,355
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Homocysteine results in increased expression of PTGS2 mRNA]; fulvic acid inhibits the reaction [Homocysteine promotes the reaction [RELA protein binds to PTGS2 promoter]]; fulvic acid inhibits the reaction [Homocysteine results in increased expression of PTGS2 mRNA]; Homocysteine promotes the reaction [RELA protein binds to PTGS2 promoter]; pyrazolanthrone inhibits the reaction [Homocysteine results in increased expression of PTGS2 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Homocysteine results in increased expression of PTGS2 mRNA]; SN50 peptide inhibits the reaction [Homocysteine results in increased expression of PTGS2 mRNA] CTD PMID:25888188 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Pycard PYD and CARD domain containing multiple interactions
increases expression
ISO [Folic Acid deficiency results in increased abundance of Homocysteine] promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]; CASP1 protein affects the reaction [Homocysteine promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]]; Homocysteine promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]; PYCARD protein affects the reaction [Homocysteine promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]]; PYCARD protein affects the reaction [Homocysteine results in decreased secretion of VEGFA protein]; PYCARD protein affects the reaction [Homocysteine results in increased activity of CASP1 protein]
Homocysteine results in increased expression of PYCARD mRNA
CTD PMID:22647887 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
JBrowse link
G Rab1b RAB1B, member RAS oncogene family multiple interactions ISO [Methionine deficiency co-treated with Homocysteine] affects the expression of RAB1B protein CTD PMID:17116298 NCBI chr 1:202,405,759...202,413,850
Ensembl chr 1:202,405,759...202,413,868
JBrowse link
G Rab9a RAB9A, member RAS oncogene family multiple interactions ISO [Methionine deficiency co-treated with Homocysteine] affects the expression of RAB9A protein CTD PMID:17116298 NCBI chr  X:27,955,552...28,009,870
Ensembl chr  X:27,952,204...28,001,622
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression
increases localization
increases activity
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Homocysteine results in increased activity of RELA protein]; [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein affects the localization of RELA protein modified form]; [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein results in increased phosphorylation of RELA protein]; fulvic acid inhibits the reaction [Homocysteine promotes the reaction [RELA protein binds to PTGS2 promoter]]; Homocysteine promotes the reaction [RELA protein binds to PTGS2 promoter]; pyrazolanthrone inhibits the reaction [Homocysteine results in increased activity of RELA protein]
Homocysteine results in increased expression of RELA protein
Homocysteine inhibits the reaction [Simvastatin results in decreased expression of RELA protein]
Homocysteine results in increased localization of RELA protein
CTD PMID:17586618 PMID:18540024 PMID:24224954 PMID:25888188 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 multiple interactions ISO [Adenosine co-treated with Homocysteine co-treated with TNF protein] results in increased cleavage of RIPK1 protein CTD PMID:24224954 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
JBrowse link
G S100a4 S100 calcium-binding protein A4 multiple interactions
increases expression
ISO [Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of S100A4 mRNA; [Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of S100A4 protein; acetovanillone inhibits the reaction [Homocysteine results in increased expression of S100A4 protein]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of S100A4 mRNA]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of S100A4 protein]; CYBB mutant form inhibits the reaction [Homocysteine results in increased expression of S100A4 protein]
Homocysteine results in increased expression of S100A4 mRNA; Homocysteine results in increased expression of S100A4 protein
CTD PMID:21647593 NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254
JBrowse link
G Slc46a1 solute carrier family 46 member 1 affects abundance ISO SLC46A1 protein affects the abundance of Homocysteine metabolite CTD PMID:19204075 NCBI chr10:63,361,504...63,367,940
Ensembl chr10:63,361,486...63,368,848
JBrowse link
G Sod1 superoxide dismutase 1 increases expression EXP Homocysteine results in increased expression of SOD1 protein CTD PMID:17485853 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO [SOD2 gene SNP results in increased susceptibility to [Air Pollutants results in increased abundance of Particulate Matter]] which results in increased abundance of Homocysteine CTD PMID:30477822 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Ssr4 signal sequence receptor subunit 4 multiple interactions ISO [Methionine deficiency co-treated with Homocysteine] affects the expression of SSR4 protein CTD PMID:17116298 NCBI chr  X:151,524,191...151,528,218
Ensembl chr  X:151,524,009...151,528,202
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions
increases expression
EXP Dizocilpine Maleate inhibits the reaction [Homocysteine analog results in increased expression of TIMP1 mRNA]; Dizocilpine Maleate inhibits the reaction [Homocysteine analog results in increased expression of TIMP1 protein]
Homocysteine analog results in increased expression of TIMP1 mRNA; Homocysteine analog results in increased expression of TIMP1 protein
CTD PMID:20406136 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions
decreases expression
ISO [Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of TJP1 mRNA; acetovanillone inhibits the reaction [Homocysteine results in decreased expression of TJP1 protein]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of TJP1 mRNA]; CYBB mutant form inhibits the reaction [Homocysteine results in decreased expression of TJP1 protein]
Homocysteine results in decreased expression of TJP1 mRNA; Homocysteine results in decreased expression of TJP1 protein
CTD PMID:21647593 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO
EXP
[Adenosine co-treated with Homocysteine co-treated with TNF protein] results in increased cleavage of RIPK1 protein; [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein affects the localization of RELA protein modified form]; [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein results in increased phosphorylation of RELA protein]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of TNFAIP3 mRNA]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]; [Adenosine co-treated with Homocysteine] results in increased susceptibility to TNF protein
Homocysteine results in increased expression of TNF protein
CTD PMID:24224954 PMID:27203204 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 multiple interactions ISO [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of TNFAIP3 mRNA]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]; [Adenosine co-treated with Homocysteine] results in decreased expression of TNFAIP3 mRNA; [Adenosine co-treated with Homocysteine] results in decreased expression of TNFAIP3 protein CTD PMID:24224954 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
JBrowse link
G Tp53 tumor protein p53 increases phosphorylation
affects expression
multiple interactions
EXP
ISO
Homocysteine results in increased phosphorylation of TP53 protein
Homocysteine affects the expression of TP53 mRNA; Homocysteine affects the expression of TP53 protein
Folic Acid affects the reaction [Homocysteine affects the expression of TP53 mRNA]; Folic Acid affects the reaction [Homocysteine affects the expression of TP53 protein]
CTD PMID:13679428 PMID:29250709 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Vbp1 VHL binding protein 1 multiple interactions ISO [Methionine deficiency co-treated with Homocysteine] affects the expression of VBP1 protein CTD PMID:17116298
G Vcam1 vascular cell adhesion molecule 1 multiple interactions
increases expression
ISO 3,4-dihydroxyphenylethanol inhibits the reaction [Homocysteine results in increased expression of VCAM1 protein]; resveratrol inhibits the reaction [Homocysteine results in increased expression of VCAM1 protein]
Homocysteine results in increased expression of VCAM1 mRNA; Homocysteine results in increased expression of VCAM1 protein
CTD PMID:17586618 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vdac1 voltage-dependent anion channel 1 increases expression
multiple interactions
ISO Homocysteine results in increased expression of VDAC1 protein
Homocysteine promotes the reaction [HSPA9 protein binds to VDAC1 protein]
CTD PMID:33751715 NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases expression
decreases expression
decreases secretion
ISO
EXP
Amitriptyline inhibits the reaction [Homocysteine results in decreased secretion of VEGFA protein]; CASP1 protein affects the reaction [Homocysteine results in decreased secretion of VEGFA protein]; CYBB protein affects the reaction [Homocysteine results in decreased secretion of VEGFA protein]; diphenyleneiodonium inhibits the reaction [Homocysteine results in decreased secretion of VEGFA protein]; Homocysteine results in decreased expression of and results in decreased secretion of VEGFA protein; PYCARD protein affects the reaction [Homocysteine results in decreased secretion of VEGFA protein]
Homocysteine results in increased expression of VEGFA protein
Homocysteine results in decreased expression of VEGFA mRNA
CTD PMID:17485853 PMID:20116427 PMID:22647887 PMID:23024785 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vim vimentin increases expression EXP Homocysteine results in increased expression of VIM protein CTD PMID:17485853 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Vps29 VPS29 retromer complex component multiple interactions ISO [Methionine deficiency co-treated with Homocysteine] affects the expression of VPS29 protein CTD PMID:17116298 NCBI chr12:34,208,911...34,217,977
Ensembl chr12:34,207,263...34,217,964
JBrowse link
G Wnt5a Wnt family member 5A decreases expression ISO Homocysteine results in decreased expression of WNT5A mRNA CTD PMID:17320366 NCBI chr16:3,695,667...3,718,234
Ensembl chr16:3,697,032...3,718,234
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions
decreases expression
increases expression
increases splicing
ISO Glycine affects the reaction [Homocysteine results in increased splicing of XBP1 mRNA]
Homocysteine results in decreased expression of XBP1 protein
Homocysteine results in increased expression of XBP1 mRNA alternative form
CTD PMID:19960509 PMID:22964297 PMID:27064126 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
JBrowse link
homocysteic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions EXP [homocysteic acid co-treated with GW 506033X] results in increased phosphorylation of EIF2S1 protein CTD PMID:19046382 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Hsf1 heat shock transcription factor 1 decreases expression EXP homocysteic acid results in decreased expression of HSF1 protein CTD PMID:24478344 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Sp1 Sp1 transcription factor increases activity
multiple interactions
ISO homocysteic acid results in increased activity of SP1 protein
mithramycin A inhibits the reaction [homocysteic acid results in increased activity of SP1 protein]
CTD PMID:11261509 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
JBrowse link
G Sp3 Sp3 transcription factor multiple interactions
increases activity
ISO mithramycin A inhibits the reaction [homocysteic acid results in increased activity of SP3 protein] CTD PMID:11261509 NCBI chr 3:57,811,855...57,857,150
Ensembl chr 3:57,812,075...57,860,342
JBrowse link
S-adenosyl-L-homocysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahcy adenosylhomocysteinase increases hydrolysis ISO AHCY results in increased hydrolysis of S-Adenosylhomocysteine CTD PMID:26974671 NCBI chr 3:143,569,134...143,584,359
Ensembl chr 3:143,569,094...143,584,393
JBrowse link
G Ahr aryl hydrocarbon receptor increases abundance
multiple interactions
ISO AHR protein results in increased abundance of S-Adenosylhomocysteine
PEMT protein promotes the reaction [AHR protein results in increased abundance of S-Adenosylhomocysteine]
CTD PMID:29416063 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Alas2 5'-aminolevulinate synthase 2 multiple interactions ISO [S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of ALAS2 mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of ALAS2 mRNA] CTD PMID:24141029 NCBI chr  X:19,463,146...19,486,526
Ensembl chr  X:19,463,171...19,486,519
JBrowse link
G App amyloid beta precursor protein increases expression
decreases methylation
multiple interactions
ISO S-Adenosylhomocysteine results in increased expression of APP protein
S-Adenosylhomocysteine results in decreased methylation of APP promoter
Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of APP promoter]; Betaine inhibits the reaction [S-Adenosylhomocysteine results in increased expression of and results in increased cleavage of APP protein]; S-Adenosylhomocysteine results in increased expression of and results in increased cleavage of APP protein
CTD PMID:19635394 PMID:22064374 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Atp7b ATPase copper transporting beta increases abundance ISO ATP7B protein mutant form results in increased abundance of S-Adenosylhomocysteine CTD PMID:22945834 NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636
JBrowse link
G Bace1 beta-secretase 1 increases expression ISO S-Adenosylhomocysteine results in increased expression of BACE1 protein CTD PMID:19635394 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876
JBrowse link
G Carm1 coactivator-associated arginine methyltransferase 1 decreases activity ISO S-Adenosylhomocysteine results in decreased activity of CARM1 protein CTD PMID:33577917 NCBI chr 8:20,097,262...20,141,950
Ensembl chr 8:20,097,254...20,147,689
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO S-Adenosylhomocysteine results in decreased expression of COL1A1 mRNA CTD PMID:15983038 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Col1a2 collagen type I alpha 2 chain decreases expression ISO S-Adenosylhomocysteine results in decreased expression of COL1A2 mRNA CTD PMID:15983038 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
JBrowse link
G Comt catechol-O-methyltransferase decreases activity EXP S-Adenosylhomocysteine results in decreased activity of COMT protein CTD PMID:10064789 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases activity
multiple interactions
ISO S-Adenosylhomocysteine results in decreased activity of DNMT1 protein
S-Adenosylhomocysteine inhibits the reaction [DNMT1 protein binds to OGG1 promoter]
CTD PMID:16037419 PMID:22064374 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
JBrowse link
G Fgf19 fibroblast growth factor 19 decreases abundance ISO FGF19 protein results in decreased abundance of S-Adenosylhomocysteine CTD PMID:29416063 NCBI chr 1:200,056,656...200,059,944
Ensembl chr 1:200,056,644...200,060,287
JBrowse link
G Hbb hemoglobin subunit beta multiple interactions ISO [S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HBB mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HBB mRNA] CTD PMID:24141029 NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012
JBrowse link
G Hmbs hydroxymethylbilane synthase multiple interactions ISO [S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HMBS mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HMBS mRNA] CTD PMID:24141029 NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957
JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression
multiple interactions
ISO
EXP
S-Adenosylhomocysteine results in increased expression of MMP2 mRNA; S-Adenosylhomocysteine results in increased expression of MMP2 protein
S-Adenosylhomocysteine promotes the reaction [SP1 protein binds to MMP2 promoter]
U 0126 inhibits the reaction [S-Adenosylhomocysteine results in increased expression of MMP2 protein]
CTD PMID:19770485 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Nfkbia NFKB inhibitor alpha decreases expression EXP S-Adenosylhomocysteine results in decreased expression of NFKBIA protein CTD PMID:19770485 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases abundance ISO NR0B2 protein results in decreased abundance of S-Adenosylhomocysteine CTD PMID:29416063 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase multiple interactions
decreases methylation
decreases expression
ISO Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased expression of OGG1 protein]; Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of OGG1 promoter]; S-Adenosylhomocysteine inhibits the reaction [DNMT1 protein binds to OGG1 promoter]
S-Adenosylhomocysteine results in decreased expression of OGG1 mRNA; S-Adenosylhomocysteine results in decreased expression of OGG1 protein
CTD PMID:22064374 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
JBrowse link
G Pemt phosphatidylethanolamine N-methyltransferase multiple interactions ISO PEMT protein promotes the reaction [AHR protein results in increased abundance of S-Adenosylhomocysteine] CTD PMID:29416063 NCBI chr10:44,775,910...44,849,990
Ensembl chr10:44,775,911...44,850,013
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO S-Adenosylhomocysteine results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Prmt1 protein arginine methyltransferase 1 decreases activity ISO S-Adenosylhomocysteine results in decreased activity of PRMT1 protein CTD PMID:33577917 NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345
JBrowse link
G Prmt5 protein arginine methyltransferase 5 decreases activity ISO S-Adenosylhomocysteine results in decreased activity of PRMT5 protein CTD PMID:33577917 NCBI chr15:27,968,893...27,978,291
Ensembl chr15:27,968,910...27,978,296
JBrowse link
G Prmt6 protein arginine methyltransferase 6 decreases activity ISO S-Adenosylhomocysteine results in decreased activity of PRMT6 protein CTD PMID:33577917 NCBI chr 2:197,927,750...197,932,980
Ensembl chr 2:197,927,220...197,933,648
JBrowse link
G Prmt7 protein arginine methyltransferase 7 decreases activity ISO S-Adenosylhomocysteine results in decreased activity of PRMT7 protein CTD PMID:33577917 NCBI chr19:34,110,724...34,161,531
Ensembl chr19:34,110,747...34,162,577
JBrowse link
G Psen1 presenilin 1 multiple interactions
decreases methylation
increases expression
ISO Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of PSEN1 promoter]
S-Adenosylhomocysteine results in increased expression of PSEN1 protein
CTD PMID:19635394 NCBI chr 6:103,323,014...103,375,088
Ensembl chr 6:103,323,120...103,371,650
JBrowse link
G Slc19a1 solute carrier family 19 member 1 affects abundance ISO SLC19A1 protein affects the abundance of S-Adenosylhomocysteine CTD PMID:15705887 NCBI chr20:11,584,410...11,602,429
Ensembl chr20:11,584,411...11,601,972
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions EXP S-Adenosylhomocysteine promotes the reaction [SP1 protein binds to MMP2 promoter] CTD PMID:19770485 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 decreases expression ISO S-Adenosylhomocysteine results in decreased expression of TIMP2 protein CTD PMID:19770485 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20059
    role 20009
      biological role 20008
        biochemical role 19630
          metabolite 19611
            fundamental metabolite 12804
              homocysteine 137
                L-homocysteine + 0
                homocysteic acid + 4
                homocysteine derivative + 28
Path 2
Term Annotations click to browse term
  CHEBI ontology 20059
    subatomic particle 20056
      composite particle 20056
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19873
                          organic molecular entity 19873
                            organic group 18943
                              organic divalent group 18928
                                organodiyl group 18928
                                  carbonyl group 18877
                                    carbonyl compound 18877
                                      carboxylic acid 18565
                                        amino acid 14936
                                          alpha-amino acid 12944
                                            non-proteinogenic alpha-amino acid 1760
                                              homocysteines 411
                                                homocysteine 137
                                                  L-homocysteine + 0
                                                  homocysteic acid + 4
                                                  homocysteine derivative + 28
paths to the root