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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:rosmarinic acid
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Accession:CHEBI:17226 term browser browse the term
Definition:The 1-carboxy-2-(2,4-dihydroxyphenyl)ethyl ester of trans-caffeic acid.
Synonyms:exact_synonym: 3-(3,4-dihydroxyphenyl)-2-[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyloxy]propanoic acid
 related_synonym: Formula=C18H16O8;   InChI=1S/C18H16O8/c19-12-4-1-10(7-14(12)21)3-6-17(23)26-16(18(24)25)9-11-2-5-13(20)15(22)8-11/h1-8,16,19-22H,9H2,(H,24,25)/b6-3+;   InChIKey=DOUMFZQKYFQNTF-ZZXKWVIFSA-N;   R-(+)-2-(3,4-Dihydroxycinnamoyloxy)-3-(3,4-dihydroxyphenyl)propionic acid;   SMILES=OC(=O)C(Cc1ccc(O)c(O)c1)OC(=O)\\C=C\\c1ccc(O)c(O)c1;   alpha-(((3,4-Dihydroxyphenyl)-1-oxo-2-propenyl)oxy)-3,4-dihydroxy- benzenepropanoic acid
 alt_id: CHEBI:15055;   CHEBI:26582;   CHEBI:8894;   CHEBI:8895
 xref: CAS:537-15-5
 xref_mesh: MESH:C041376
 xref: PMID:12482446;   PMID:20071057;   PMID:21364781;   PMID:21838541;   PMID:22236574;   PMID:22439433;   PMID:23016274;   PMID:23116643;   PMID:23122135;   PMID:23381830;   PMID:23414442;   PMID:23548128;   PMID:24085626;   PMID:24097334;   PMID:24262570
 cyclic_relationship: is_conjugate_acid_of CHEBI:58062


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rosmarinic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle decreases expression
multiple interactions
EXP rosmarinic acid results in decreased expression of ACTA2 protein
rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]
CTD PMID:28789951 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Adam17 ADAM metallopeptidase domain 17 multiple interactions
decreases expression
ISO [rosmarinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein]] which affects the localization of PROCR protein; [rosmarinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein]] which results in decreased cleavage of and results in decreased secretion of PROCR protein; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein affects the localization of PROCR protein]; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein results in increased cleavage of and results in increased secretion of PROCR protein]; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein affects the localization of PROCR protein]; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein results in increased cleavage of and results in increased secretion of PROCR protein]; rosmarinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein] CTD PMID:23774263 NCBI chr 6:43,400,525...43,448,280
Ensembl chr 6:43,400,528...43,448,280
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions ISO rosmarinic acid inhibits the reaction [Cadmium affects the localization of AIFM1 protein] CTD PMID:23548128 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
rosmarinic acid inhibits the reaction [Cadmium results in increased activity of CASP3 protein]
rosmarinic acid inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]
CTD PMID:23548128, PMID:28815802 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase multiple interactions
increases activity
increases expression
ISO rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased activity of CAT protein]; rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of CAT mRNA]
rosmarinic acid results in increased activity of CAT protein
rosmarinic acid results in increased expression of CAT mRNA
CTD PMID:31610155 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions
decreases expression
EXP rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of CCN2 protein]
rosmarinic acid results in decreased expression of CCN2 mRNA
CTD PMID:28789951 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Ccnd1 cyclin D1 multiple interactions EXP rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of CCND1 protein] CTD PMID:28789951 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cd68 Cd68 molecule decreases expression EXP rosmarinic acid results in decreased expression of CD68 protein CTD PMID:28789951 NCBI chr10:56,268,726...56,270,605
Ensembl chr10:56,268,720...56,270,640
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression
multiple interactions
ISO
EXP
rosmarinic acid results in decreased expression of COL1A1 mRNA
rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]
CTD PMID:27235791, PMID:28789951 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions
decreases expression
EXP rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]
rosmarinic acid results in decreased expression of COL3A1 mRNA
CTD PMID:28789951 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Crp C-reactive protein affects expression
multiple interactions
EXP rosmarinic acid affects the expression of CRP protein
2-chloro-5-nitrobenzanilide inhibits the reaction [rosmarinic acid affects the expression of CRP protein]; T 0070907 inhibits the reaction [rosmarinic acid affects the expression of CRP protein]
CTD PMID:28744220 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions
decreases expression
ISO rosmarinic acid inhibits the reaction [Particulate Matter results in increased expression of CXCL1 protein]; rosmarinic acid inhibits the reaction [Vehicle Emissions results in increased expression of CXCL1 protein]
rosmarinic acid results in decreased expression of CXCL1 mRNA
CTD PMID:12684091, PMID:26804033 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Des desmin multiple interactions EXP rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of DES protein] CTD PMID:28789951 NCBI chr 9:82,556,574...82,564,288
Ensembl chr 9:82,556,573...82,564,294
JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases expression ISO rosmarinic acid results in decreased expression of DNMT1 protein CTD PMID:21078381 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
JBrowse link
G Fn1 fibronectin 1 decreases expression ISO rosmarinic acid results in decreased expression of FN1 mRNA CTD PMID:26804033 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression EXP rosmarinic acid results in decreased expression of FOS protein CTD PMID:28789951 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gpt glutamic--pyruvic transaminase decreases activity EXP rosmarinic acid results in decreased activity of GPT protein CTD PMID:25455894 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
increases expression
ISO rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of GPX1 mRNA]
rosmarinic acid results in increased expression of GPX1 mRNA
CTD PMID:31610155 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gsto1 glutathione S-transferase omega 1 increases expression
multiple interactions
ISO rosmarinic acid results in increased expression of GSTO1 mRNA
rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of GSTO1 mRNA]
CTD PMID:31610155 NCBI chr 1:267,607,437...267,617,387
Ensembl chr 1:267,607,418...267,617,387
JBrowse link
G Hmgb1 high mobility group box 1 decreases expression EXP rosmarinic acid results in decreased expression of HMGB1 protein CTD PMID:28789951 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO rosmarinic acid results in increased expression of HMOX1 mRNA
rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of HMOX1 mRNA]
CTD PMID:31610155 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
ISO
EXP
[rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein affects the localization of PROCR protein]; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein results in increased cleavage of and results in increased secretion of PROCR protein]
rosmarinic acid results in decreased expression of IL1B mRNA; rosmarinic acid results in decreased expression of IL1B protein
rosmarinic acid inhibits the reaction [Cadmium results in increased expression of IL1B protein]; rosmarinic acid inhibits the reaction [Particulate Matter results in increased expression of IL1B protein]; rosmarinic acid inhibits the reaction [Vehicle Emissions results in increased expression of IL1B protein]
CTD PMID:12684091, PMID:23548128, PMID:23774263, PMID:25455894, PMID:28789951 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
affects expression
increases expression
ISO
EXP
rosmarinic acid inhibits the reaction [Cadmium results in increased expression of IL6 protein]
rosmarinic acid results in decreased expression of IL6 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [rosmarinic acid affects the expression of IL6 protein]; T 0070907 inhibits the reaction [rosmarinic acid affects the expression of IL6 protein]
rosmarinic acid results in increased expression of IL6 mRNA
rosmarinic acid results in decreased expression of IL6 mRNA
CTD PMID:23548128, PMID:26804033, PMID:28744220, PMID:28789951 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases phosphorylation EXP rosmarinic acid results in decreased phosphorylation of JUN protein CTD PMID:28789951 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kcnu1 potassium calcium-activated channel subfamily U member 1 decreases activity ISO rosmarinic acid results in decreased activity of KCNU1 protein CTD PMID:30009954 NCBI chr16:70,913,825...70,998,593
Ensembl chr16:70,913,817...70,998,575
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions
decreases expression
ISO rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of KEAP1 protein]
rosmarinic acid results in decreased expression of KEAP1 protein
CTD PMID:31610155 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Maoa monoamine oxidase A decreases activity ISO rosmarinic acid results in decreased activity of MAOA protein CTD PMID:27270453 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722
JBrowse link
G Maob monoamine oxidase B decreases activity ISO rosmarinic acid results in decreased activity of MAOB protein CTD PMID:27270453 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 decreases phosphorylation EXP rosmarinic acid results in decreased phosphorylation of MAP3K7 protein CTD PMID:28789951 NCBI chr 5:47,183,142...47,244,424
Ensembl chr 5:47,186,558...47,244,416
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation EXP rosmarinic acid results in decreased phosphorylation of MAPK1 protein CTD PMID:28789951 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation EXP rosmarinic acid results in decreased phosphorylation of MAPK3 protein CTD PMID:28789951 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases phosphorylation EXP rosmarinic acid results in decreased phosphorylation of MAPK8 protein CTD PMID:28789951 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 decreases phosphorylation EXP rosmarinic acid results in decreased phosphorylation of MAPK9 protein CTD PMID:28789951 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression EXP rosmarinic acid results in decreased expression of MMP2 mRNA; rosmarinic acid results in decreased expression of MMP2 protein CTD PMID:28789951 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression EXP rosmarinic acid results in decreased expression of MMP9 mRNA; rosmarinic acid results in decreased expression of MMP9 protein CTD PMID:28789951 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpo myeloperoxidase decreases expression EXP rosmarinic acid results in decreased expression of MPO protein CTD PMID:28789951 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor decreases expression EXP rosmarinic acid results in decreased expression of MYD88 protein CTD PMID:28789951 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases expression
ISO [lead acetate results in increased abundance of Lead] inhibits the reaction [rosmarinic acid results in increased expression of NFE2L2 protein]; rosmarinic acid affects the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of NFE2L2 mRNA]
rosmarinic acid results in increased expression of NFE2L2 mRNA; rosmarinic acid results in increased expression of NFE2L2 protein
CTD PMID:31610155 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions
EXP rosmarinic acid results in decreased expression of NOS2 protein
rosmarinic acid inhibits the reaction [Doxorubicin results in increased expression of NOS2 protein]
CTD PMID:25455894, PMID:28815802 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 decreases expression EXP rosmarinic acid results in decreased expression of NOS3 protein CTD PMID:25455894 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
ISO rosmarinic acid results in increased expression of NQO1 mRNA
rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of NQO1 mRNA]
CTD PMID:31610155 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase increases expression EXP rosmarinic acid results in increased expression of OGG1 mRNA CTD PMID:18996367 NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326
JBrowse link
G Parg poly (ADP-ribose) glycohydrolase decreases activity ISO rosmarinic acid results in decreased activity of PARG protein CTD PMID:19840838 NCBI chr16:8,350,168...8,457,999
Ensembl chr16:8,350,326...8,457,996
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects expression
multiple interactions
EXP rosmarinic acid affects the expression of PPARG mRNA; rosmarinic acid affects the expression of PPARG protein
2-chloro-5-nitrobenzanilide inhibits the reaction [rosmarinic acid affects the expression of PPARG mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [rosmarinic acid affects the expression of PPARG protein]; T 0070907 inhibits the reaction [rosmarinic acid affects the expression of PPARG mRNA]; T 0070907 inhibits the reaction [rosmarinic acid affects the expression of PPARG protein]
CTD PMID:28744220 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Procr protein C receptor multiple interactions
affects localization
ISO [rosmarinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein]] which affects the localization of PROCR protein; [rosmarinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein]] which results in decreased cleavage of and results in decreased secretion of PROCR protein; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein affects the localization of PROCR protein]; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein results in increased cleavage of and results in increased secretion of PROCR protein]; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein affects the localization of PROCR protein]; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein results in increased cleavage of and results in increased secretion of PROCR protein]; rosmarinic acid inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PROCR protein]; rosmarinic acid results in decreased cleavage of and results in decreased secretion of PROCR protein
rosmarinic acid affects the localization of PROCR protein
CTD PMID:23774263 NCBI chr 3:151,285,321...151,289,581
Ensembl chr 3:151,285,249...151,289,595
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization
decreases phosphorylation
affects expression
multiple interactions
EXP rosmarinic acid affects the localization of RELA protein
rosmarinic acid results in decreased phosphorylation of RELA protein
rosmarinic acid affects the expression of RELA mRNA; rosmarinic acid affects the expression of RELA protein
2-chloro-5-nitrobenzanilide inhibits the reaction [rosmarinic acid affects the expression of RELA mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [rosmarinic acid affects the expression of RELA protein]; T 0070907 inhibits the reaction [rosmarinic acid affects the expression of RELA mRNA]; T 0070907 inhibits the reaction [rosmarinic acid affects the expression of RELA protein]
CTD PMID:25455894, PMID:28744220, PMID:28789951 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Serpine1 serpin family E member 1 decreases expression ISO rosmarinic acid results in decreased expression of SERPINE1 mRNA CTD PMID:26804033 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Sod1 superoxide dismutase 1 increases expression
multiple interactions
ISO rosmarinic acid results in increased expression of SOD1 mRNA
rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SOD1 mRNA]
CTD PMID:31610155 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 increases expression
multiple interactions
ISO rosmarinic acid results in increased expression of SOD2 mRNA
rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SOD2 mRNA]
CTD PMID:31610155 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression
multiple interactions
EXP rosmarinic acid results in decreased expression of TGFB1 protein
rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of CCN2 protein]; rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of CCND1 protein]; rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]; rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of DES protein]; rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]
CTD PMID:28789951 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tlr4 toll-like receptor 4 decreases expression EXP rosmarinic acid results in decreased expression of TLR4 protein CTD PMID:28789951 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor multiple interactions
affects expression
decreases expression
ISO
EXP
[rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein affects the localization of PROCR protein]; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein results in increased cleavage of and results in increased secretion of PROCR protein]
2-chloro-5-nitrobenzanilide inhibits the reaction [rosmarinic acid affects the expression of TNF protein]; rosmarinic acid inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; T 0070907 inhibits the reaction [rosmarinic acid affects the expression of TNF protein]
rosmarinic acid results in decreased expression of TNF mRNA; rosmarinic acid results in decreased expression of TNF protein
CTD PMID:23774263, PMID:25455894, PMID:28744220, PMID:28789951, PMID:28815802 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vim vimentin multiple interactions EXP rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of VIM protein] CTD PMID:28789951 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      chemical role 19248
        antioxidant 14209
          rosmarinic acid 53
            (R)-rosmarinic acid 0
            (S)-rosmarinic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        monocarboxylic acid 17406
                                          alpha,beta-unsaturated monocarboxylic acid 11359
                                            cinnamic acids 2375
                                              hydroxycinnamic acid 1252
                                                caffeic acid 549
                                                  trans-caffeic acid 244
                                                    rosmarinic acid 53
                                                      (R)-rosmarinic acid 0
                                                      (S)-rosmarinic acid 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.