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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:rosmarinic acid
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Accession:CHEBI:17226 term browser browse the term
Definition:The 1-carboxy-2-(2,4-dihydroxyphenyl)ethyl ester of trans-caffeic acid.
Synonyms:exact_synonym: 3-(3,4-dihydroxyphenyl)-2-[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyloxy]propanoic acid
 related_synonym: Formula=C18H16O8;   InChI=1S/C18H16O8/c19-12-4-1-10(7-14(12)21)3-6-17(23)26-16(18(24)25)9-11-2-5-13(20)15(22)8-11/h1-8,16,19-22H,9H2,(H,24,25)/b6-3+;   InChIKey=DOUMFZQKYFQNTF-ZZXKWVIFSA-N;   R-(+)-2-(3,4-Dihydroxycinnamoyloxy)-3-(3,4-dihydroxyphenyl)propionic acid;   SMILES=OC(=O)C(Cc1ccc(O)c(O)c1)OC(=O)\\C=C\\c1ccc(O)c(O)c1;   alpha-(((3,4-Dihydroxyphenyl)-1-oxo-2-propenyl)oxy)-3,4-dihydroxy- benzenepropanoic acid
 alt_id: CHEBI:15055;   CHEBI:26582;   CHEBI:8894;   CHEBI:8895
 xref: CAS:537-15-5
 xref_mesh: MESH:C041376
 xref: PMID:12482446;   PMID:20071057;   PMID:21364781;   PMID:21838541;   PMID:22236574;   PMID:22439433;   PMID:23016274;   PMID:23116643;   PMID:23122135;   PMID:23381830;   PMID:23414442;   PMID:23548128;   PMID:24085626;   PMID:24097334;   PMID:24262570
 cyclic_relationship: is_conjugate_acid_of CHEBI:58062


show annotations for term's descendants           Sort by:
rosmarinic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle decreases expression
multiple interactions		 EXP rosmarinic acid results in decreased expression of ACTA2 protein
rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]		 CTD PMID:28789951 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Adam17 ADAM metallopeptidase domain 17 multiple interactions
decreases expression		 ISO [rosmarinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein]] which affects the localization of PROCR protein; [rosmarinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein]] which results in decreased cleavage of and results in decreased secretion of PROCR protein; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein affects the localization of PROCR protein]; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein results in increased cleavage of and results in increased secretion of PROCR protein]; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein affects the localization of PROCR protein]; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein results in increased cleavage of and results in increased secretion of PROCR protein]; rosmarinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein] CTD PMID:23774263 NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions ISO rosmarinic acid inhibits the reaction [Cadmium affects the localization of AIFM1 protein] CTD PMID:23548128 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression		 ISO
EXP		 rosmarinic acid inhibits the reaction [Cadmium results in increased activity of CASP3 protein]
rosmarinic acid results in increased expression of CASP3 mRNA
rosmarinic acid inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]		 CTD PMID:23548128 PMID:28815802 PMID:36863647 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases activity
increases expression		 ISO rosmarinic acid results in increased activity of CASP8 protein
rosmarinic acid results in increased expression of CASP8 mRNA		 CTD PMID:36863647 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Cat catalase multiple interactions
increases activity
increases expression		 ISO rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased activity of CAT protein]; rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of CAT mRNA]
rosmarinic acid results in increased activity of CAT protein
rosmarinic acid results in increased expression of CAT mRNA		 CTD PMID:31610155 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions
decreases expression		 EXP rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of CCN2 protein]
rosmarinic acid results in decreased expression of CCN2 mRNA		 CTD PMID:28789951 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions EXP rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of CCND1 protein] CTD PMID:28789951 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cd68 Cd68 molecule decreases expression EXP rosmarinic acid results in decreased expression of CD68 protein CTD PMID:28789951 NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression
multiple interactions		 ISO
EXP		 rosmarinic acid results in decreased expression of COL1A1 mRNA
rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]		 CTD PMID:27235791 PMID:28789951 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions
decreases expression		 EXP rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]
rosmarinic acid results in decreased expression of COL3A1 mRNA		 CTD PMID:28789951 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Crp C-reactive protein affects expression
multiple interactions		 EXP rosmarinic acid affects the expression of CRP protein
2-chloro-5-nitrobenzanilide inhibits the reaction [rosmarinic acid affects the expression of CRP protein]; T 0070907 inhibits the reaction [rosmarinic acid affects the expression of CRP protein]		 CTD PMID:28744220 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions
decreases expression		 ISO rosmarinic acid inhibits the reaction [Particulate Matter results in increased expression of CXCL1 protein]; rosmarinic acid inhibits the reaction [Vehicle Emissions results in increased expression of CXCL1 protein]
rosmarinic acid results in decreased expression of CXCL1 mRNA		 CTD PMID:12684091 PMID:26804033 NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Des desmin multiple interactions EXP rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of DES protein] CTD PMID:28789951 NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699 		JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases expression ISO rosmarinic acid results in decreased expression of DNMT1 protein CTD PMID:21078381 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659 		JBrowse link
G Fn1 fibronectin 1 decreases expression ISO rosmarinic acid results in decreased expression of FN1 mRNA CTD PMID:26804033 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression EXP rosmarinic acid results in decreased expression of FOS protein CTD PMID:28789951 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gpt glutamic--pyruvic transaminase decreases activity EXP rosmarinic acid results in decreased activity of GPT protein CTD PMID:25455894 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
increases expression		 ISO rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of GPX1 mRNA]
rosmarinic acid results in increased expression of GPX1 mRNA		 CTD PMID:31610155 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gsto1 glutathione S-transferase omega 1 increases expression
multiple interactions		 ISO rosmarinic acid results in increased expression of GSTO1 mRNA
rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of GSTO1 mRNA]		 CTD PMID:31610155 NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468 		JBrowse link
G Hmgb1 high mobility group box 1 decreases expression EXP rosmarinic acid results in decreased expression of HMGB1 protein CTD PMID:28789951 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 ISO rosmarinic acid results in increased expression of HMOX1 mRNA
rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of HMOX1 mRNA]		 CTD PMID:31610155 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression		 ISO
EXP		 [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein affects the localization of PROCR protein]; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein results in increased cleavage of and results in increased secretion of PROCR protein]
rosmarinic acid results in decreased expression of IL1B mRNA; rosmarinic acid results in decreased expression of IL1B protein
rosmarinic acid inhibits the reaction [Cadmium results in increased expression of IL1B protein]; rosmarinic acid inhibits the reaction [Particulate Matter results in increased expression of IL1B protein]; rosmarinic acid inhibits the reaction [Vehicle Emissions results in increased expression of IL1B protein]		 CTD PMID:12684091 PMID:23548128 PMID:23774263 PMID:25455894 PMID:28789951 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
affects expression
increases expression		 ISO
EXP		 rosmarinic acid inhibits the reaction [Cadmium results in increased expression of IL6 protein]
rosmarinic acid results in decreased expression of IL6 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [rosmarinic acid affects the expression of IL6 protein]; T 0070907 inhibits the reaction [rosmarinic acid affects the expression of IL6 protein]
rosmarinic acid results in increased expression of IL6 mRNA
rosmarinic acid results in decreased expression of IL6 mRNA		 CTD PMID:23548128 PMID:26804033 PMID:28744220 PMID:28789951 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases phosphorylation EXP rosmarinic acid results in decreased phosphorylation of JUN protein CTD PMID:28789951 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kcnu1 potassium calcium-activated channel subfamily U member 1 decreases activity ISO rosmarinic acid results in decreased activity of KCNU1 protein CTD PMID:30009954 NCBI chr16:66,141,696...66,229,493
Ensembl chr16:66,141,976...66,229,465 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions
decreases expression		 ISO rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of KEAP1 protein]
rosmarinic acid results in decreased expression of KEAP1 protein		 CTD PMID:31610155 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Maoa monoamine oxidase A decreases activity ISO rosmarinic acid results in decreased activity of MAOA protein CTD PMID:27270453 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593 		JBrowse link
G Maob monoamine oxidase B decreases activity ISO rosmarinic acid results in decreased activity of MAOB protein CTD PMID:27270453 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 decreases phosphorylation EXP rosmarinic acid results in decreased phosphorylation of MAP3K7 protein CTD PMID:28789951 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation EXP rosmarinic acid results in decreased phosphorylation of MAPK1 protein CTD PMID:28789951 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation EXP rosmarinic acid results in decreased phosphorylation of MAPK3 protein CTD PMID:28789951 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases phosphorylation EXP rosmarinic acid results in decreased phosphorylation of MAPK8 protein CTD PMID:28789951 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 decreases phosphorylation EXP rosmarinic acid results in decreased phosphorylation of MAPK9 protein CTD PMID:28789951 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression EXP rosmarinic acid results in decreased expression of MMP2 mRNA; rosmarinic acid results in decreased expression of MMP2 protein CTD PMID:28789951 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression EXP rosmarinic acid results in decreased expression of MMP9 mRNA; rosmarinic acid results in decreased expression of MMP9 protein CTD PMID:28789951 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase decreases expression EXP rosmarinic acid results in decreased expression of MPO protein CTD PMID:28789951 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor decreases expression EXP rosmarinic acid results in decreased expression of MYD88 protein CTD PMID:28789951 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression		 ISO [lead acetate results in increased abundance of Lead] inhibits the reaction [rosmarinic acid results in increased expression of NFE2L2 protein]; rosmarinic acid affects the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of NFE2L2 mRNA]
rosmarinic acid results in increased expression of NFE2L2 mRNA; rosmarinic acid results in increased expression of NFE2L2 protein		 CTD PMID:31610155 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 decreases expression ISO rosmarinic acid results in decreased expression of NLRP3 mRNA CTD PMID:36863647 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions		 EXP rosmarinic acid results in decreased expression of NOS2 protein
rosmarinic acid inhibits the reaction [Doxorubicin results in increased expression of NOS2 protein]		 CTD PMID:25455894 PMID:28815802 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 decreases expression EXP rosmarinic acid results in decreased expression of NOS3 protein CTD PMID:25455894 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions		 ISO rosmarinic acid results in increased expression of NQO1 mRNA
rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of NQO1 mRNA]		 CTD PMID:31610155 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase increases expression EXP rosmarinic acid results in increased expression of OGG1 mRNA CTD PMID:18996367 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766 		JBrowse link
G Parg poly (ADP-ribose) glycohydrolase decreases activity ISO rosmarinic acid results in decreased activity of PARG protein CTD PMID:19840838 NCBI chr16:7,436,429...7,544,276
Ensembl chr16:7,436,476...7,544,273 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects expression
multiple interactions		 EXP rosmarinic acid affects the expression of PPARG mRNA; rosmarinic acid affects the expression of PPARG protein
2-chloro-5-nitrobenzanilide inhibits the reaction [rosmarinic acid affects the expression of PPARG mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [rosmarinic acid affects the expression of PPARG protein]; T 0070907 inhibits the reaction [rosmarinic acid affects the expression of PPARG mRNA]; T 0070907 inhibits the reaction [rosmarinic acid affects the expression of PPARG protein]		 CTD PMID:28744220 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Procr protein C receptor multiple interactions
affects localization		 ISO [rosmarinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein]] which affects the localization of PROCR protein; [rosmarinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein]] which results in decreased cleavage of and results in decreased secretion of PROCR protein; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein affects the localization of PROCR protein]; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein results in increased cleavage of and results in increased secretion of PROCR protein]; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein affects the localization of PROCR protein]; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein results in increased cleavage of and results in increased secretion of PROCR protein]; rosmarinic acid inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PROCR protein]; rosmarinic acid results in decreased cleavage of and results in decreased secretion of PROCR protein
rosmarinic acid affects the localization of PROCR protein		 CTD PMID:23774263 NCBI chr 3:144,254,596...144,258,863
Ensembl chr 3:144,254,380...144,258,903 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization
decreases phosphorylation
affects expression
multiple interactions		 EXP rosmarinic acid affects the localization of RELA protein
rosmarinic acid results in decreased phosphorylation of RELA protein
rosmarinic acid affects the expression of RELA mRNA; rosmarinic acid affects the expression of RELA protein
2-chloro-5-nitrobenzanilide inhibits the reaction [rosmarinic acid affects the expression of RELA mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [rosmarinic acid affects the expression of RELA protein]; T 0070907 inhibits the reaction [rosmarinic acid affects the expression of RELA mRNA]; T 0070907 inhibits the reaction [rosmarinic acid affects the expression of RELA protein]		 CTD PMID:25455894 PMID:28744220 PMID:28789951 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Serpine1 serpin family E member 1 decreases expression ISO rosmarinic acid results in decreased expression of SERPINE1 mRNA CTD PMID:26804033 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Sod1 superoxide dismutase 1 increases expression
multiple interactions		 ISO rosmarinic acid results in increased expression of SOD1 mRNA
rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SOD1 mRNA]		 CTD PMID:31610155 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression
multiple interactions		 ISO rosmarinic acid results in increased expression of SOD2 mRNA
rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SOD2 mRNA]		 CTD PMID:31610155 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression
multiple interactions		 EXP rosmarinic acid results in decreased expression of TGFB1 protein
rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of CCN2 protein]; rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of CCND1 protein]; rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]; rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of DES protein]; rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]		 CTD PMID:28789951 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tlr4 toll-like receptor 4 decreases expression EXP rosmarinic acid results in decreased expression of TLR4 protein CTD PMID:28789951 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
affects expression
decreases expression		 ISO
EXP		 [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein affects the localization of PROCR protein]; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein results in increased cleavage of and results in increased secretion of PROCR protein]
2-chloro-5-nitrobenzanilide inhibits the reaction [rosmarinic acid affects the expression of TNF protein]; rosmarinic acid inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; T 0070907 inhibits the reaction [rosmarinic acid affects the expression of TNF protein]
rosmarinic acid results in decreased expression of TNF mRNA; rosmarinic acid results in decreased expression of TNF protein		 CTD PMID:23774263 PMID:25455894 PMID:28744220 PMID:28789951 PMID:28815802 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vim vimentin multiple interactions EXP rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of VIM protein] CTD PMID:28789951 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19876
    role 19851
      chemical role 19472
        antioxidant 16032
          rosmarinic acid 55
            (R)-rosmarinic acid 0
            (S)-rosmarinic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19876
    subatomic particle 19874
      composite particle 19874
        hadron 19874
          baryon 19874
            nucleon 19874
              atomic nucleus 19905
                atom 19905
                  main group element atom 19821
                    p-block element atom 19821
                      carbon group element atom 19768
                        carbon atom 19764
                          organic molecular entity 19764
                            organic group 18962
                              organic divalent group 18943
                                organodiyl group 18915
                                  carbonyl group 18869
                                    carbonyl compound 18869
                                      carboxylic acid 18618
                                        monocarboxylic acid 17917
                                          alpha,beta-unsaturated monocarboxylic acid 13224
                                            cinnamic acids 2496
                                              hydroxycinnamic acid 1349
                                                caffeic acid 585
                                                  trans-caffeic acid 281
                                                    rosmarinic acid 55
                                                      (R)-rosmarinic acid 0
                                                      (S)-rosmarinic acid 0
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