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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2-butenoic acid
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Accession:CHEBI:17217 term browser browse the term
Definition:A butenoic acid having the double bond at position C-2.
Synonyms:exact_synonym: but-2-enoic acid
 related_synonym: 2-Butenoate;   2-butenic acid;   3-methylacrylic acid;   CTA;   Crotonic acid;   Crotonsaeure;   Formula=C4H6O2;   InChI=1S/C4H6O2/c1-2-3-4(5)6/h2-3H,1H3,(H,5,6);   InChIKey=LDHQCZJRKDOVOX-UHFFFAOYSA-N;   SMILES=[H]C(C)=CC(O)=O;   acide crotonique;   alpha-butenoic acid;   alpha-crotonic acid;   beta-methacrylic acid;   beta-methylacrylic acid
 alt_id: CHEBI:1027;   CHEBI:19484;   CHEBI:19485
 xref: Beilstein:1098434;   CAS:3724-65-0;   Gmelin:324286;   KEGG:C01771;   Reaxys:1098434
 cyclic_relationship: is_conjugate_acid_of CHEBI:36258


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mevinphos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
decreases activity
ISO [Mevinphos co-treated with Dichlorvos] results in decreased activity of ACHE protein; asoxime chloride inhibits the reaction [Mevinphos results in decreased activity of ACHE protein]; HLo 7 inhibits the reaction [Mevinphos results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [Mevinphos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Mevinphos results in decreased activity of ACHE protein] CTD PMID:4859365 PMID:8783813 PMID:21251949 NCBI chr 5:137,288,247...137,294,466
Ensembl chr 5:137,287,519...137,294,466
JBrowse link
G Agtr1a angiotensin II receptor, type 1a increases expression
multiple interactions
ISO Mevinphos results in increased expression of AGTR1A mRNA; Mevinphos results in increased expression of AGTR1A protein
[Mevinphos results in increased activity of AGTR1A protein] promotes the reaction [NOX1 protein results in increased abundance of Superoxides]
CTD PMID:23824088 NCBI chr13:30,336,356...30,382,867
Ensembl chr13:30,336,441...30,382,867
JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions
increases expression
ISO [Mevinphos results in increased activity of AGTR2 protein] which results in increased abundance of Peroxynitrous Acid
Mevinphos results in increased expression of AGTR2 mRNA; Mevinphos results in increased expression of AGTR2 protein
CTD PMID:23824088 NCBI chr  X:21,484,624...21,488,833
Ensembl chr  X:21,484,544...21,489,164
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 increases phosphorylation
multiple interactions
ISO Mevinphos results in increased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Mevinphos results in increased activity of and results in increased phosphorylation of AKT1 protein]; AKT1 protein modified form affects the reaction [Mevinphos results in increased activity of RELA protein]; Mevinphos results in increased activity of and results in increased phosphorylation of AKT1 protein; PI103 inhibits the reaction [Mevinphos results in increased activity of and results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Mevinphos results in increased activity of and results in increased phosphorylation of AKT1 protein]
CTD PMID:24462917 PMID:25449601 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO ARNT protein affects the reaction [Mevinphos results in increased expression of NOS1 protein]; ARNT protein affects the reaction [Mevinphos results in increased expression of PRKG1 protein]; Mevinphos promotes the reaction [HIF1A protein binds to ARNT protein] CTD PMID:21390240 NCBI chr 3:95,434,367...95,497,240
Ensembl chr 3:95,434,388...95,497,240
JBrowse link
G Atf2 activating transcription factor 2 increases phosphorylation ISO Mevinphos results in increased phosphorylation of ATF2 protein CTD PMID:23157661 NCBI chr 2:73,816,509...73,892,677
Ensembl chr 2:73,816,509...73,892,639
JBrowse link
G Bax BCL2-associated X protein affects expression
multiple interactions
ISO Mevinphos affects the expression of BAX protein
HSPD1 protein affects the reaction [Mevinphos affects the expression of BAX protein]; Mevinphos promotes the reaction [HSPD1 protein binds to BAX protein]
CTD PMID:17150954 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
affects expression
ISO HSPD1 protein affects the reaction [Mevinphos affects the expression of BCL2 protein]; Mevinphos affects the reaction [HSPD1 protein binds to BCL2 protein] CTD PMID:17150954 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO HSPD1 protein affects the reaction [Mevinphos results in increased activity of CASP3 protein] CTD PMID:17150954 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Cep55 centrosomal protein 55 increases expression ISO Mevinphos results in increased expression of CEP55 mRNA; Mevinphos results in increased expression of CEP55 protein CTD PMID:25449601 NCBI chr19:38,054,970...38,074,425
Ensembl chr19:38,055,011...38,074,423
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2, cardiac increases activity ISO Mevinphos results in increased activity of CHRM2 protein CTD PMID:17395621 NCBI chr 6:36,387,991...36,528,638
Ensembl chr 6:36,388,084...36,528,414
JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 increases activity ISO Mevinphos results in increased activity of CHRM4 protein CTD PMID:17395621 NCBI chr 2:91,922,189...91,929,835
Ensembl chr 2:91,927,249...91,928,688
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit multiple interactions ISO HIF1A protein affects the reaction [Mevinphos results in increased expression of HMOX1 protein]; HIF1A protein affects the reaction [Mevinphos results in increased expression of NOS1 protein]; HIF1A protein affects the reaction [Mevinphos results in increased expression of PRKG1 protein]; Mevinphos promotes the reaction [HIF1A protein binds to ARNT protein]; Mevinphos promotes the reaction [HIF1A protein binds to SUMO1 protein]; Mevinphos results in increased expression of and affects the localization of HIF1A protein; Mevinphos results in increased expression of and results in increased activity of HIF1A protein; SUMO1 protein affects the reaction [Mevinphos results in increased expression of and results in increased activity of HIF1A protein]; UBE2I protein affects the reaction [Mevinphos results in increased expression of and results in increased activity of HIF1A protein] CTD PMID:19333137 PMID:21390240 NCBI chr12:73,901,324...73,947,554
Ensembl chr12:73,901,375...73,947,530
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO Mevinphos results in increased expression of HMOX1 protein
HIF1A protein affects the reaction [Mevinphos results in increased expression of HMOX1 protein]
CTD PMID:19333137 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Hspa9 heat shock protein 9 increases expression ISO Mevinphos results in increased expression of HSPA9 protein CTD PMID:17150954 NCBI chr18:34,937,414...34,954,351
Ensembl chr18:34,937,414...34,954,357
JBrowse link
G Hspd1 heat shock protein 1 (chaperonin) increases expression
multiple interactions
ISO Mevinphos results in increased expression of HSPD1 mRNA; Mevinphos results in increased expression of HSPD1 protein
HSPD1 protein affects the reaction [Mevinphos affects the expression of BAX protein]; HSPD1 protein affects the reaction [Mevinphos affects the expression of BCL2 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased activity of CASP3 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased expression of NOS1 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased expression of NOS2 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased expression of PRKG1 protein]; Mevinphos affects the reaction [HSPD1 protein binds to BCL2 protein]; Mevinphos promotes the reaction [HSPD1 protein binds to BAX protein]
CTD PMID:17150954 NCBI chr 1:55,077,833...55,088,243
Ensembl chr 1:55,077,835...55,088,243
JBrowse link
G Il2 interleukin 2 decreases response to substance EXP Mevinphos results in decreased susceptibility to IL2 protein CTD PMID:8349949 NCBI chr 3:37,120,713...37,125,954
Ensembl chr 3:37,120,523...37,125,959
JBrowse link
G Jun jun proto-oncogene increases phosphorylation ISO Mevinphos results in increased phosphorylation of JUN protein CTD PMID:23157661 NCBI chr 4:95,049,036...95,052,222
Ensembl chr 4:95,049,034...95,052,222
JBrowse link
G Map2k4 mitogen-activated protein kinase kinase 4 increases phosphorylation ISO Mevinphos results in increased phosphorylation of MAP2K4 protein CTD PMID:23157661 NCBI chr11:65,688,244...65,788,359
Ensembl chr11:65,688,243...65,788,297
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 increases phosphorylation ISO Mevinphos results in increased phosphorylation of MAP2K6 protein CTD PMID:23157661 NCBI chr11:110,399,102...110,525,522
Ensembl chr11:110,399,122...110,525,522
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions ISO methoctramine inhibits the reaction [Mevinphos affects the localization of and affects the activity of NFKB1 protein]; Mevinphos affects the localization of and affects the activity of NFKB1 protein; Tropicamide inhibits the reaction [Mevinphos affects the localization of and affects the activity of NFKB1 protein] CTD PMID:17395621 NCBI chr 3:135,584,655...135,691,969
Ensembl chr 3:135,584,655...135,691,547
JBrowse link
G Nos1 nitric oxide synthase 1, neuronal multiple interactions
increases activity
increases expression
ISO ARNT protein affects the reaction [Mevinphos results in increased expression of NOS1 protein]; HIF1A protein affects the reaction [Mevinphos results in increased expression of NOS1 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased expression of NOS1 protein]; KT 5720 inhibits the reaction [Mevinphos results in increased expression of NOS1 protein]; methoctramine inhibits the reaction [Mevinphos results in increased expression of NOS1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Mevinphos results in increased expression of NOS1 protein]; Tropicamide inhibits the reaction [Mevinphos results in increased expression of NOS1 protein]
Mevinphos results in increased activity of NOS1 protein
Mevinphos results in increased expression of NOS1 mRNA; Mevinphos results in increased expression of NOS1 protein
CTD PMID:15111025 PMID:15617736 PMID:17150954 PMID:17395621 PMID:17438462 PMID:21390240 PMID:24462917 PMID:28601397 NCBI chr 5:117,866,839...117,958,840
Ensembl chr 5:117,781,032...117,958,840
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions
increases activity
increases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased expression of NOS2 protein]; methoctramine inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]; PTEN protein inhibits the reaction [Mevinphos results in increased expression of NOS2 mRNA]; PTEN protein inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]; triciribine inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]; Tropicamide inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]; Wortmannin inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]
Mevinphos results in increased activity of NOS2 protein
Mevinphos results in increased expression of NOS2; Mevinphos results in increased expression of NOS2 mRNA; Mevinphos results in increased expression of NOS2 protein
CTD PMID:15111025 PMID:15617736 PMID:17150954 PMID:17395621 PMID:21390240 PMID:24462917 PMID:25449601 PMID:28601397 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions ISO [Mevinphos results in increased activity of AGTR1A protein] promotes the reaction [NOX1 protein results in increased abundance of Superoxides] CTD PMID:23824088 NCBI chr  X:134,086,421...134,137,711
Ensembl chr  X:134,086,421...134,221,956
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions
increases phosphorylation
ISO PIK3R1 protein affects the reaction [Mevinphos results in increased activity of RELA protein]
Mevinphos results in increased phosphorylation of PIK3R1 protein
CTD PMID:24462917 NCBI chr13:101,680,761...101,768,217
Ensembl chr13:101,680,563...101,768,217
JBrowse link
G Prkg1 protein kinase, cGMP-dependent, type I multiple interactions
increases expression
ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Mevinphos results in increased expression of PRKG1 protein]; 7-nitroindazole inhibits the reaction [Mevinphos results in increased expression of PRKG1 protein]; ARNT protein affects the reaction [Mevinphos results in increased expression of PRKG1 protein]; HIF1A protein affects the reaction [Mevinphos results in increased expression of PRKG1 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased expression of PRKG1 protein]
Mevinphos results in increased expression of PRKG1 mRNA; Mevinphos results in increased expression of PRKG1 protein
CTD PMID:15617736 PMID:17150954 PMID:21390240 PMID:28601397 NCBI chr19:30,564,487...31,765,268
Ensembl chr19:30,564,489...31,765,033
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO Mevinphos results in increased activity of and results in decreased oxidation of PTEN protein; PTEN protein inhibits the reaction [Mevinphos results in increased expression of NOS2 mRNA]; PTEN protein inhibits the reaction [Mevinphos results in increased expression of NOS2 protein] CTD PMID:28601397 NCBI chr19:32,757,577...32,826,160
Ensembl chr19:32,757,497...32,826,160
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions
increases activity
ISO AKT1 protein modified form affects the reaction [Mevinphos results in increased activity of RELA protein]; methoctramine inhibits the reaction [Mevinphos affects the localization of and affects the activity of RELA protein]; Mevinphos affects the localization of and affects the activity of RELA protein; PIK3R1 protein affects the reaction [Mevinphos results in increased activity of RELA protein]; triciribine inhibits the reaction [Mevinphos results in increased activity of RELA protein]; Tropicamide inhibits the reaction [Mevinphos affects the localization of and affects the activity of RELA protein]; Wortmannin inhibits the reaction [Mevinphos results in increased activity of RELA protein] CTD PMID:17395621 PMID:24462917 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Sumo1 small ubiquitin-like modifier 1 multiple interactions ISO Mevinphos promotes the reaction [HIF1A protein binds to SUMO1 protein]; SUMO1 protein affects the reaction [Mevinphos results in increased expression of and results in increased activity of HIF1A protein] CTD PMID:21390240 NCBI chr 1:59,639,434...59,670,834
Ensembl chr 1:59,586,558...59,670,834
JBrowse link
G Ube2i ubiquitin-conjugating enzyme E2I multiple interactions ISO Mevinphos results in increased expression of and results in increased activity of UBE2I protein; UBE2I protein affects the reaction [Mevinphos results in increased expression of and results in increased activity of HIF1A protein] CTD PMID:21390240 NCBI chr17:25,260,510...25,275,799
Ensembl chr17:25,261,916...25,274,622
JBrowse link
G Uchl1 ubiquitin carboxy-terminal hydrolase L1 increases expression
multiple interactions
ISO Mevinphos results in increased expression of UCHL1 protein
Cycloheximide inhibits the reaction [Mevinphos results in increased expression of UCHL1 protein]; Dactinomycin inhibits the reaction [Mevinphos results in increased expression of UCHL1 protein]
CTD PMID:15545831 NCBI chr 5:66,676,121...66,687,234
Ensembl chr 5:66,676,091...66,687,234
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21720
    chemical entity 21718
      atom 21705
        nonmetal atom 21599
          carbon atom 21326
            organic molecular entity 21326
              lipid 18452
                fatty acid 16597
                  short-chain fatty acid 16243
                    butenoic acid 31
                      2-butenoic acid 31
                        (Z)-2-aminobutenoic acid 0
                        2-aminobut-2-enoic acid 0
                        2-hydroxy-4-(1-oxo-1,3-dihydro-2H-inden-2-ylidene) but-2-enoic acid 0
                        2-hydroxy-4-(2-oxo-1,3-dihydro-2H-inden-1-ylidene) but-2-enoic acid 0
                        2-methylbut-2-enoic acid + 0
                        3-methylbut-2-enoic acid + 0
                        but-2-enoate ester + 0
                        but-2-enoyl-CoA + 0
                        crotonic acid + 0
                        isocrotonic acid + 0
                        methyl 3-hydroxybut-2-enoate + 31
Path 2
Term Annotations click to browse term
  CHEBI ontology 21720
    subatomic particle 21705
      composite particle 21705
        hadron 21705
          baryon 21705
            nucleon 21705
              atomic nucleus 21705
                atom 21705
                  main group element atom 21622
                    p-block element atom 21622
                      carbon group element atom 21427
                        carbon atom 21326
                          organic molecular entity 21326
                            organic group 19886
                              organic divalent group 19876
                                organodiyl group 19876
                                  carbonyl group 19859
                                    carbonyl compound 19859
                                      carboxylic acid 19157
                                        monocarboxylic acid 18458
                                          fatty acid 16597
                                            unsaturated fatty acid 955
                                              monounsaturated fatty acid 455
                                                butenoic acid 31
                                                  2-butenoic acid 31
                                                    (Z)-2-aminobutenoic acid 0
                                                    2-aminobut-2-enoic acid 0
                                                    2-hydroxy-4-(1-oxo-1,3-dihydro-2H-inden-2-ylidene) but-2-enoic acid 0
                                                    2-hydroxy-4-(2-oxo-1,3-dihydro-2H-inden-1-ylidene) but-2-enoic acid 0
                                                    2-methylbut-2-enoic acid + 0
                                                    3-methylbut-2-enoic acid + 0
                                                    but-2-enoate ester + 0
                                                    but-2-enoyl-CoA + 0
                                                    crotonic acid + 0
                                                    isocrotonic acid + 0
                                                    methyl 3-hydroxybut-2-enoate + 31
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