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G |
ACHE |
acetylcholinesterase (Yt blood group) |
multiple interactions decreases activity |
EXP ISO |
[Mevinphos co-treated with Dichlorvos] results in decreased activity of ACHE protein; asoxime chloride inhibits the reaction [Mevinphos results in decreased activity of ACHE protein]; HLo 7 inhibits the reaction [Mevinphos results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [Mevinphos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Mevinphos results in decreased activity of ACHE protein] |
CTD |
PMID:4859365 PMID:8783813 PMID:21251949 |
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NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
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G |
AGTR1 |
angiotensin II receptor type 1 |
multiple interactions increases expression |
ISO |
[Mevinphos results in increased activity of AGTR1A protein] promotes the reaction [NOX1 protein results in increased abundance of Superoxides] Mevinphos results in increased expression of AGTR1A mRNA; Mevinphos results in increased expression of AGTR1A protein |
CTD |
PMID:23824088 |
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NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008
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G |
AGTR2 |
angiotensin II receptor type 2 |
multiple interactions increases expression |
ISO |
[Mevinphos results in increased activity of AGTR2 protein] which results in increased abundance of Peroxynitrous Acid Mevinphos results in increased expression of AGTR2 mRNA; Mevinphos results in increased expression of AGTR2 protein |
CTD |
PMID:23824088 |
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NCBI chr X:116,170,744...116,174,974
Ensembl chr X:116,170,744...116,174,974
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G |
AKT1 |
AKT serine/threonine kinase 1 |
increases phosphorylation multiple interactions |
ISO |
Mevinphos results in increased phosphorylation of AKT1 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Mevinphos results in increased activity of and results in increased phosphorylation of AKT1 protein]; AKT1 protein modified form affects the reaction [Mevinphos results in increased activity of RELA protein]; Mevinphos results in increased activity of and results in increased phosphorylation of AKT1 protein; PI103 inhibits the reaction [Mevinphos results in increased activity of and results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Mevinphos results in increased activity of and results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:24462917 PMID:25449601 |
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NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
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G |
ARNT |
aryl hydrocarbon receptor nuclear translocator |
multiple interactions |
ISO |
ARNT protein affects the reaction [Mevinphos results in increased expression of NOS1 protein]; ARNT protein affects the reaction [Mevinphos results in increased expression of PRKG1 protein]; Mevinphos promotes the reaction [HIF1A protein binds to ARNT protein] |
CTD |
PMID:21390240 |
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NCBI chr 1:150,809,713...150,876,599
Ensembl chr 1:150,809,713...150,876,708
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G |
ATF2 |
activating transcription factor 2 |
increases phosphorylation |
ISO |
Mevinphos results in increased phosphorylation of ATF2 protein |
CTD |
PMID:23157661 |
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NCBI chr 2:175,072,259...175,168,203
Ensembl chr 2:175,072,250...175,168,382
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G |
BAX |
BCL2 associated X, apoptosis regulator |
affects expression multiple interactions |
ISO |
Mevinphos affects the expression of BAX protein HSPD1 protein affects the reaction [Mevinphos affects the expression of BAX protein]; Mevinphos promotes the reaction [HSPD1 protein binds to BAX protein] |
CTD |
PMID:17150954 |
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NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
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G |
BCL2 |
BCL2 apoptosis regulator |
affects expression multiple interactions |
ISO |
Mevinphos affects the expression of BCL2 protein HSPD1 protein affects the reaction [Mevinphos affects the expression of BCL2 protein]; Mevinphos affects the reaction [HSPD1 protein binds to BCL2 protein] |
CTD |
PMID:17150954 |
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NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
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G |
CASP3 |
caspase 3 |
multiple interactions increases activity |
ISO |
HSPD1 protein affects the reaction [Mevinphos results in increased activity of CASP3 protein] |
CTD |
PMID:17150954 |
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NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
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G |
CEP55 |
centrosomal protein 55 |
increases expression |
ISO |
Mevinphos results in increased expression of CEP55 mRNA; Mevinphos results in increased expression of CEP55 protein |
CTD |
PMID:25449601 |
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NCBI chr10:93,496,612...93,529,092
Ensembl chr10:93,496,612...93,529,092
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G |
CHRM2 |
cholinergic receptor muscarinic 2 |
increases activity |
ISO |
Mevinphos results in increased activity of CHRM2 protein |
CTD |
PMID:17395621 |
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NCBI chr 7:136,868,652...137,020,213
Ensembl chr 7:136,868,652...137,020,255
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G |
CHRM4 |
cholinergic receptor muscarinic 4 |
increases activity |
ISO |
Mevinphos results in increased activity of CHRM4 protein |
CTD |
PMID:17395621 |
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NCBI chr11:46,383,789...46,391,776
Ensembl chr11:46,383,789...46,391,776
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G |
HIF1A |
hypoxia inducible factor 1 subunit alpha |
multiple interactions |
ISO |
HIF1A protein affects the reaction [Mevinphos results in increased expression of HMOX1 protein]; HIF1A protein affects the reaction [Mevinphos results in increased expression of NOS1 protein]; HIF1A protein affects the reaction [Mevinphos results in increased expression of PRKG1 protein]; Mevinphos promotes the reaction [HIF1A protein binds to ARNT protein]; Mevinphos promotes the reaction [HIF1A protein binds to SUMO1 protein]; Mevinphos results in increased expression of and affects the localization of HIF1A protein; Mevinphos results in increased expression of and results in increased activity of HIF1A protein; SUMO1 protein affects the reaction [Mevinphos results in increased expression of and results in increased activity of HIF1A protein]; UBE2I protein affects the reaction [Mevinphos results in increased expression of and results in increased activity of HIF1A protein] |
CTD |
PMID:19333137 PMID:21390240 |
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NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259
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G |
HMOX1 |
heme oxygenase 1 |
increases expression multiple interactions |
ISO |
Mevinphos results in increased expression of HMOX1 protein HIF1A protein affects the reaction [Mevinphos results in increased expression of HMOX1 protein] |
CTD |
PMID:19333137 |
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NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
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G |
HSPA9 |
heat shock protein family A (Hsp70) member 9 |
increases expression |
ISO |
Mevinphos results in increased expression of HSPA9 protein |
CTD |
PMID:17150954 |
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NCBI chr 5:138,553,756...138,575,401
Ensembl chr 5:138,553,756...138,575,675
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G |
HSPD1 |
heat shock protein family D (Hsp60) member 1 |
increases expression multiple interactions |
ISO |
Mevinphos results in increased expression of HSPD1 mRNA; Mevinphos results in increased expression of HSPD1 protein HSPD1 protein affects the reaction [Mevinphos affects the expression of BAX protein]; HSPD1 protein affects the reaction [Mevinphos affects the expression of BCL2 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased activity of CASP3 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased expression of NOS1 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased expression of NOS2 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased expression of PRKG1 protein]; Mevinphos affects the reaction [HSPD1 protein binds to BCL2 protein]; Mevinphos promotes the reaction [HSPD1 protein binds to BAX protein] |
CTD |
PMID:17150954 |
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NCBI chr 2:197,486,584...197,500,274
Ensembl chr 2:197,486,584...197,516,737
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G |
IL2 |
interleukin 2 |
decreases response to substance |
ISO |
Mevinphos results in decreased susceptibility to IL2 protein |
CTD |
PMID:8349949 |
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NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
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G |
JUN |
Jun proto-oncogene, AP-1 transcription factor subunit |
increases phosphorylation |
ISO |
Mevinphos results in increased phosphorylation of JUN protein |
CTD |
PMID:23157661 |
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NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048
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G |
MAP2K4 |
mitogen-activated protein kinase kinase 4 |
increases phosphorylation |
ISO |
Mevinphos results in increased phosphorylation of MAP2K4 protein |
CTD |
PMID:23157661 |
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NCBI chr17:12,020,877...12,143,828
Ensembl chr17:12,020,829...12,143,830
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G |
MAP2K6 |
mitogen-activated protein kinase kinase 6 |
increases phosphorylation |
ISO |
Mevinphos results in increased phosphorylation of MAP2K6 protein |
CTD |
PMID:23157661 |
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NCBI chr17:69,414,697...69,553,865
Ensembl chr17:69,414,697...69,553,865
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G |
NFKB1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
methoctramine inhibits the reaction [Mevinphos affects the localization of and affects the activity of NFKB1 protein]; Mevinphos affects the localization of and affects the activity of NFKB1 protein; Tropicamide inhibits the reaction [Mevinphos affects the localization of and affects the activity of NFKB1 protein] |
CTD |
PMID:17395621 |
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NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302
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G |
NOS1 |
nitric oxide synthase 1 |
multiple interactions increases activity increases expression |
ISO |
ARNT protein affects the reaction [Mevinphos results in increased expression of NOS1 protein]; HIF1A protein affects the reaction [Mevinphos results in increased expression of NOS1 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased expression of NOS1 protein]; KT 5720 inhibits the reaction [Mevinphos results in increased expression of NOS1 protein]; methoctramine inhibits the reaction [Mevinphos results in increased expression of NOS1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Mevinphos results in increased expression of NOS1 protein]; Tropicamide inhibits the reaction [Mevinphos results in increased expression of NOS1 protein] Mevinphos results in increased activity of NOS1 protein Mevinphos results in increased expression of NOS1 mRNA; Mevinphos results in increased expression of NOS1 protein |
CTD |
PMID:15111025 PMID:15617736 PMID:17150954 PMID:17395621 PMID:17438462 PMID:21390240 PMID:24462917 PMID:28601397 More...
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NCBI chr12:117,208,142...117,361,626
Ensembl chr12:117,208,142...117,452,170
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G |
NOS2 |
nitric oxide synthase 2 |
multiple interactions increases activity increases expression |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased expression of NOS2 protein]; methoctramine inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]; PTEN protein inhibits the reaction [Mevinphos results in increased expression of NOS2 mRNA]; PTEN protein inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]; triciribine inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]; Tropicamide inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]; Wortmannin inhibits the reaction [Mevinphos results in increased expression of NOS2 protein] Mevinphos results in increased activity of NOS2 protein Mevinphos results in increased expression of NOS2; Mevinphos results in increased expression of NOS2 mRNA; Mevinphos results in increased expression of NOS2 protein |
CTD |
PMID:15111025 PMID:15617736 PMID:17150954 PMID:17395621 PMID:21390240 PMID:24462917 PMID:25449601 PMID:28601397 More...
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NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
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G |
NOX1 |
NADPH oxidase 1 |
multiple interactions |
ISO |
[Mevinphos results in increased activity of AGTR1A protein] promotes the reaction [NOX1 protein results in increased abundance of Superoxides] |
CTD |
PMID:23824088 |
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NCBI chr X:100,843,324...100,874,359
Ensembl chr X:100,843,324...100,874,359
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G |
PIK3R1 |
phosphoinositide-3-kinase regulatory subunit 1 |
increases phosphorylation multiple interactions |
ISO |
Mevinphos results in increased phosphorylation of PIK3R1 protein PIK3R1 protein affects the reaction [Mevinphos results in increased activity of RELA protein] |
CTD |
PMID:24462917 |
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NCBI chr 5:68,215,756...68,301,821
Ensembl chr 5:68,215,740...68,301,821
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G |
PRKG1 |
protein kinase cGMP-dependent 1 |
multiple interactions increases expression |
ISO |
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Mevinphos results in increased expression of PRKG1 protein]; 7-nitroindazole inhibits the reaction [Mevinphos results in increased expression of PRKG1 protein]; ARNT protein affects the reaction [Mevinphos results in increased expression of PRKG1 protein]; HIF1A protein affects the reaction [Mevinphos results in increased expression of PRKG1 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased expression of PRKG1 protein] Mevinphos results in increased expression of PRKG1 mRNA; Mevinphos results in increased expression of PRKG1 protein |
CTD |
PMID:15617736 PMID:17150954 PMID:21390240 PMID:28601397 |
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NCBI chr10:50,990,888...52,298,350
Ensembl chr10:50,990,888...52,298,423
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G |
PTEN |
phosphatase and tensin homolog |
multiple interactions |
ISO |
Mevinphos results in increased activity of and results in decreased oxidation of PTEN protein; PTEN protein inhibits the reaction [Mevinphos results in increased expression of NOS2 mRNA]; PTEN protein inhibits the reaction [Mevinphos results in increased expression of NOS2 protein] |
CTD |
PMID:28601397 |
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NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,862,638...87,971,930
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G |
RELA |
RELA proto-oncogene, NF-kB subunit |
multiple interactions increases activity |
ISO |
AKT1 protein modified form affects the reaction [Mevinphos results in increased activity of RELA protein]; methoctramine inhibits the reaction [Mevinphos affects the localization of and affects the activity of RELA protein]; Mevinphos affects the localization of and affects the activity of RELA protein; PIK3R1 protein affects the reaction [Mevinphos results in increased activity of RELA protein]; triciribine inhibits the reaction [Mevinphos results in increased activity of RELA protein]; Tropicamide inhibits the reaction [Mevinphos affects the localization of and affects the activity of RELA protein]; Wortmannin inhibits the reaction [Mevinphos results in increased activity of RELA protein] |
CTD |
PMID:17395621 PMID:24462917 |
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NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090
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G |
SUMO1 |
small ubiquitin like modifier 1 |
multiple interactions |
ISO |
Mevinphos promotes the reaction [HIF1A protein binds to SUMO1 protein]; SUMO1 protein affects the reaction [Mevinphos results in increased expression of and results in increased activity of HIF1A protein] |
CTD |
PMID:21390240 |
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NCBI chr 2:202,206,171...202,238,597
Ensembl chr 2:202,206,182...202,238,599
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G |
TP53 |
tumor protein p53 |
affects activity |
EXP |
Mevinphos metabolite affects the activity of TP53 protein |
CTD |
PMID:35435491 |
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NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
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G |
UBE2I |
ubiquitin conjugating enzyme E2 I |
multiple interactions |
ISO |
Mevinphos results in increased expression of and results in increased activity of UBE2I protein; UBE2I protein affects the reaction [Mevinphos results in increased expression of and results in increased activity of HIF1A protein] |
CTD |
PMID:21390240 |
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NCBI chr16:1,309,152...1,327,017
Ensembl chr16:1,291,444...1,327,018
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G |
UCHL1 |
ubiquitin C-terminal hydrolase L1 |
increases expression multiple interactions |
ISO |
Mevinphos results in increased expression of UCHL1 protein Cycloheximide inhibits the reaction [Mevinphos results in increased expression of UCHL1 protein]; Dactinomycin inhibits the reaction [Mevinphos results in increased expression of UCHL1 protein] |
CTD |
PMID:15545831 |
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NCBI chr 4:41,256,928...41,268,455
Ensembl chr 4:41,256,413...41,268,455
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