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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2-butenoic acid
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Accession:CHEBI:17217 term browser browse the term
Definition:A butenoic acid having the double bond at position C-2.
Synonyms:exact_synonym: but-2-enoic acid
 related_synonym: 2-Butenoate;   2-butenic acid;   3-methylacrylic acid;   CTA;   Crotonic acid;   Crotonsaeure;   Formula=C4H6O2;   InChI=1S/C4H6O2/c1-2-3-4(5)6/h2-3H,1H3,(H,5,6);   InChIKey=LDHQCZJRKDOVOX-UHFFFAOYSA-N;   SMILES=[H]C(C)=CC(O)=O;   acide crotonique;   alpha-butenoic acid;   alpha-crotonic acid;   beta-methacrylic acid;   beta-methylacrylic acid
 alt_id: CHEBI:1027;   CHEBI:19484;   CHEBI:19485
 xref: Beilstein:1098434;   CAS:3724-65-0;   Gmelin:324286;   KEGG:C01771;   Reaxys:1098434
 cyclic_relationship: is_conjugate_acid_of CHEBI:36258


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mevinphos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase (Cartwright blood group) multiple interactions
decreases activity
EXP
ISO
[Mevinphos co-treated with Dichlorvos] results in decreased activity of ACHE protein; asoxime chloride inhibits the reaction [Mevinphos results in decreased activity of ACHE protein]; HLo 7 inhibits the reaction [Mevinphos results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [Mevinphos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Mevinphos results in decreased activity of ACHE protein] CTD PMID:4859365 PMID:8783813 PMID:21251949 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
JBrowse link
G AGTR1 angiotensin II receptor type 1 multiple interactions
increases expression
ISO [Mevinphos results in increased activity of AGTR1A protein] promotes the reaction [NOX1 protein results in increased abundance of Superoxides]
Mevinphos results in increased expression of AGTR1A mRNA; Mevinphos results in increased expression of AGTR1A protein
CTD PMID:23824088 NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008
JBrowse link
G AGTR2 angiotensin II receptor type 2 multiple interactions
increases expression
ISO [Mevinphos results in increased activity of AGTR2 protein] which results in increased abundance of Peroxynitrous Acid
Mevinphos results in increased expression of AGTR2 mRNA; Mevinphos results in increased expression of AGTR2 protein
CTD PMID:23824088 NCBI chr  X:116,170,744...116,174,974
Ensembl chr  X:116,170,744...116,174,974
JBrowse link
G AKT1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
ISO Mevinphos results in increased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Mevinphos results in increased activity of and results in increased phosphorylation of AKT1 protein]; AKT1 protein modified form affects the reaction [Mevinphos results in increased activity of RELA protein]; Mevinphos results in increased activity of and results in increased phosphorylation of AKT1 protein; PI103 inhibits the reaction [Mevinphos results in increased activity of and results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Mevinphos results in increased activity of and results in increased phosphorylation of AKT1 protein]
CTD PMID:24462917 PMID:25449601 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G ARNT aryl hydrocarbon receptor nuclear translocator multiple interactions ISO ARNT protein affects the reaction [Mevinphos results in increased expression of NOS1 protein]; ARNT protein affects the reaction [Mevinphos results in increased expression of PRKG1 protein]; Mevinphos promotes the reaction [HIF1A protein binds to ARNT protein] CTD PMID:21390240 NCBI chr 1:150,809,713...150,876,737
Ensembl chr 1:150,809,713...150,876,708
JBrowse link
G ATF2 activating transcription factor 2 increases phosphorylation ISO Mevinphos results in increased phosphorylation of ATF2 protein CTD PMID:23157661 NCBI chr 2:175,072,259...175,168,203
Ensembl chr 2:175,072,250...175,168,382
JBrowse link
G BAX BCL2 associated X, apoptosis regulator affects expression
multiple interactions
ISO Mevinphos affects the expression of BAX protein
HSPD1 protein affects the reaction [Mevinphos affects the expression of BAX protein]; Mevinphos promotes the reaction [HSPD1 protein binds to BAX protein]
CTD PMID:17150954 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator affects expression
multiple interactions
ISO Mevinphos affects the expression of BCL2 protein
HSPD1 protein affects the reaction [Mevinphos affects the expression of BCL2 protein]; Mevinphos affects the reaction [HSPD1 protein binds to BCL2 protein]
CTD PMID:17150954 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G CASP3 caspase 3 multiple interactions
increases activity
ISO HSPD1 protein affects the reaction [Mevinphos results in increased activity of CASP3 protein] CTD PMID:17150954 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CEP55 centrosomal protein 55 increases expression ISO Mevinphos results in increased expression of CEP55 mRNA; Mevinphos results in increased expression of CEP55 protein CTD PMID:25449601 NCBI chr10:93,496,612...93,529,094
Ensembl chr10:93,496,612...93,529,092
JBrowse link
G CHRM2 cholinergic receptor muscarinic 2 increases activity ISO Mevinphos results in increased activity of CHRM2 protein CTD PMID:17395621 NCBI chr 7:136,868,652...137,020,213
Ensembl chr 7:136,868,669...137,020,255
Ensembl chr 7:136,868,669...137,020,255
JBrowse link
G CHRM4 cholinergic receptor muscarinic 4 increases activity ISO Mevinphos results in increased activity of CHRM4 protein CTD PMID:17395621 NCBI chr11:46,383,789...46,391,776
Ensembl chr11:46,385,098...46,386,608
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions ISO HIF1A protein affects the reaction [Mevinphos results in increased expression of HMOX1 protein]; HIF1A protein affects the reaction [Mevinphos results in increased expression of NOS1 protein]; HIF1A protein affects the reaction [Mevinphos results in increased expression of PRKG1 protein]; Mevinphos promotes the reaction [HIF1A protein binds to ARNT protein]; Mevinphos promotes the reaction [HIF1A protein binds to SUMO1 protein]; Mevinphos results in increased expression of and affects the localization of HIF1A protein; Mevinphos results in increased expression of and results in increased activity of HIF1A protein; SUMO1 protein affects the reaction [Mevinphos results in increased expression of and results in increased activity of HIF1A protein]; UBE2I protein affects the reaction [Mevinphos results in increased expression of and results in increased activity of HIF1A protein] CTD PMID:19333137 PMID:21390240 NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259
JBrowse link
G HMOX1 heme oxygenase 1 increases expression
multiple interactions
ISO Mevinphos results in increased expression of HMOX1 protein
HIF1A protein affects the reaction [Mevinphos results in increased expression of HMOX1 protein]
CTD PMID:19333137 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G HSPA9 heat shock protein family A (Hsp70) member 9 increases expression ISO Mevinphos results in increased expression of HSPA9 protein CTD PMID:17150954 NCBI chr 5:138,553,756...138,575,401
Ensembl chr 5:138,553,756...138,575,416
Ensembl chr 5:138,553,756...138,575,416
JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 increases expression
multiple interactions
ISO Mevinphos results in increased expression of HSPD1 mRNA; Mevinphos results in increased expression of HSPD1 protein
HSPD1 protein affects the reaction [Mevinphos affects the expression of BAX protein]; HSPD1 protein affects the reaction [Mevinphos affects the expression of BCL2 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased activity of CASP3 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased expression of NOS1 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased expression of NOS2 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased expression of PRKG1 protein]; Mevinphos affects the reaction [HSPD1 protein binds to BCL2 protein]; Mevinphos promotes the reaction [HSPD1 protein binds to BAX protein]
CTD PMID:17150954 NCBI chr 2:197,486,584...197,500,274
Ensembl chr 2:197,486,584...197,516,737
JBrowse link
G IL2 interleukin 2 decreases response to substance ISO Mevinphos results in decreased susceptibility to IL2 protein CTD PMID:8349949 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit increases phosphorylation ISO Mevinphos results in increased phosphorylation of JUN protein CTD PMID:23157661 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047
JBrowse link
G MAP2K4 mitogen-activated protein kinase kinase 4 increases phosphorylation ISO Mevinphos results in increased phosphorylation of MAP2K4 protein CTD PMID:23157661 NCBI chr17:12,020,822...12,143,828
Ensembl chr17:12,020,829...12,143,830
JBrowse link
G MAP2K6 mitogen-activated protein kinase kinase 6 increases phosphorylation ISO Mevinphos results in increased phosphorylation of MAP2K6 protein CTD PMID:23157661 NCBI chr17:69,414,697...69,553,865
Ensembl chr17:69,414,697...69,553,865
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions ISO methoctramine inhibits the reaction [Mevinphos affects the localization of and affects the activity of NFKB1 protein]; Mevinphos affects the localization of and affects the activity of NFKB1 protein; Tropicamide inhibits the reaction [Mevinphos affects the localization of and affects the activity of NFKB1 protein] CTD PMID:17395621 NCBI chr 4:102,501,266...102,617,302
Ensembl chr 4:102,501,331...102,617,302
JBrowse link
G NOS1 nitric oxide synthase 1 multiple interactions
increases activity
increases expression
ISO ARNT protein affects the reaction [Mevinphos results in increased expression of NOS1 protein]; HIF1A protein affects the reaction [Mevinphos results in increased expression of NOS1 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased expression of NOS1 protein]; KT 5720 inhibits the reaction [Mevinphos results in increased expression of NOS1 protein]; methoctramine inhibits the reaction [Mevinphos results in increased expression of NOS1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Mevinphos results in increased expression of NOS1 protein]; Tropicamide inhibits the reaction [Mevinphos results in increased expression of NOS1 protein]
Mevinphos results in increased activity of NOS1 protein
Mevinphos results in increased expression of NOS1 mRNA; Mevinphos results in increased expression of NOS1 protein
CTD PMID:15111025 PMID:15617736 PMID:17150954 PMID:17395621 PMID:17438462 PMID:21390240 PMID:24462917 PMID:28601397 NCBI chr12:117,208,142...117,361,626
Ensembl chr12:117,208,142...117,452,170
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions
increases activity
increases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased expression of NOS2 protein]; methoctramine inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]; PTEN protein inhibits the reaction [Mevinphos results in increased expression of NOS2 mRNA]; PTEN protein inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]; triciribine inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]; Tropicamide inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]; Wortmannin inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]
Mevinphos results in increased activity of NOS2 protein
Mevinphos results in increased expression of NOS2; Mevinphos results in increased expression of NOS2 mRNA; Mevinphos results in increased expression of NOS2 protein
CTD PMID:15111025 PMID:15617736 PMID:17150954 PMID:17395621 PMID:21390240 PMID:24462917 PMID:25449601 PMID:28601397 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NOX1 NADPH oxidase 1 multiple interactions ISO [Mevinphos results in increased activity of AGTR1A protein] promotes the reaction [NOX1 protein results in increased abundance of Superoxides] CTD PMID:23824088 NCBI chr  X:100,843,324...100,874,359
Ensembl chr  X:100,843,324...100,874,359
JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 increases phosphorylation
multiple interactions
ISO Mevinphos results in increased phosphorylation of PIK3R1 protein
PIK3R1 protein affects the reaction [Mevinphos results in increased activity of RELA protein]
CTD PMID:24462917 NCBI chr 5:68,215,737...68,301,821
Ensembl chr 5:68,215,756...68,301,821
JBrowse link
G PRKG1 protein kinase cGMP-dependent 1 multiple interactions
increases expression
ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Mevinphos results in increased expression of PRKG1 protein]; 7-nitroindazole inhibits the reaction [Mevinphos results in increased expression of PRKG1 protein]; ARNT protein affects the reaction [Mevinphos results in increased expression of PRKG1 protein]; HIF1A protein affects the reaction [Mevinphos results in increased expression of PRKG1 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased expression of PRKG1 protein]
Mevinphos results in increased expression of PRKG1 mRNA; Mevinphos results in increased expression of PRKG1 protein
CTD PMID:15617736 PMID:17150954 PMID:21390240 PMID:28601397 NCBI chr10:50,990,888...52,298,350
Ensembl chr10:50,990,888...52,298,423
JBrowse link
G PTEN phosphatase and tensin homolog multiple interactions ISO Mevinphos results in increased activity of and results in decreased oxidation of PTEN protein; PTEN protein inhibits the reaction [Mevinphos results in increased expression of NOS2 mRNA]; PTEN protein inhibits the reaction [Mevinphos results in increased expression of NOS2 protein] CTD PMID:28601397 NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,863,625...87,971,930
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions
increases activity
ISO AKT1 protein modified form affects the reaction [Mevinphos results in increased activity of RELA protein]; methoctramine inhibits the reaction [Mevinphos affects the localization of and affects the activity of RELA protein]; Mevinphos affects the localization of and affects the activity of RELA protein; PIK3R1 protein affects the reaction [Mevinphos results in increased activity of RELA protein]; triciribine inhibits the reaction [Mevinphos results in increased activity of RELA protein]; Tropicamide inhibits the reaction [Mevinphos affects the localization of and affects the activity of RELA protein]; Wortmannin inhibits the reaction [Mevinphos results in increased activity of RELA protein] CTD PMID:17395621 PMID:24462917 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G SUMO1 small ubiquitin like modifier 1 multiple interactions ISO Mevinphos promotes the reaction [HIF1A protein binds to SUMO1 protein]; SUMO1 protein affects the reaction [Mevinphos results in increased expression of and results in increased activity of HIF1A protein] CTD PMID:21390240 NCBI chr 2:202,206,171...202,238,597
Ensembl chr 2:202,206,180...202,238,608
Ensembl chr 2:202,206,180...202,238,608
JBrowse link
G UBE2I ubiquitin conjugating enzyme E2 I multiple interactions ISO Mevinphos results in increased expression of and results in increased activity of UBE2I protein; UBE2I protein affects the reaction [Mevinphos results in increased expression of and results in increased activity of HIF1A protein] CTD PMID:21390240 NCBI chr16:1,309,152...1,327,017
Ensembl chr16:1,308,880...1,327,018
JBrowse link
G UCHL1 ubiquitin C-terminal hydrolase L1 increases expression
multiple interactions
ISO Mevinphos results in increased expression of UCHL1 protein
Cycloheximide inhibits the reaction [Mevinphos results in increased expression of UCHL1 protein]; Dactinomycin inhibits the reaction [Mevinphos results in increased expression of UCHL1 protein]
CTD PMID:15545831 NCBI chr 4:41,256,928...41,268,455
Ensembl chr 4:41,256,413...41,268,455
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24481
    chemical entity 24449
      atom 24438
        nonmetal atom 24154
          carbon atom 24040
            organic molecular entity 24040
              lipid 20084
                fatty acid 18324
                  short-chain fatty acid 17899
                    butenoic acid 31
                      2-butenoic acid 31
                        (Z)-2-aminobutenoic acid 0
                        2-aminobut-2-enoic acid 0
                        2-hydroxy-4-(1-oxo-1,3-dihydro-2H-inden-2-ylidene) but-2-enoic acid 0
                        2-hydroxy-4-(2-oxo-1,3-dihydro-2H-inden-1-ylidene) but-2-enoic acid 0
                        2-methylbut-2-enoic acid + 0
                        3-methylbut-2-enoic acid + 0
                        but-2-enoate ester + 0
                        but-2-enoyl-CoA + 0
                        crotonic acid + 0
                        isocrotonic acid + 0
                        methyl 3-hydroxybut-2-enoate + 31
Path 2
Term Annotations click to browse term
  CHEBI ontology 24481
    subatomic particle 24438
      composite particle 24438
        hadron 24438
          baryon 24438
            nucleon 24438
              atomic nucleus 24438
                atom 24438
                  main group element atom 24295
                    p-block element atom 24295
                      carbon group element atom 24079
                        carbon atom 24040
                          organic molecular entity 24040
                            organic group 22406
                              organic divalent group 22383
                                organodiyl group 22383
                                  carbonyl group 22368
                                    carbonyl compound 22368
                                      carboxylic acid 21367
                                        monocarboxylic acid 20327
                                          fatty acid 18324
                                            unsaturated fatty acid 968
                                              monounsaturated fatty acid 456
                                                butenoic acid 31
                                                  2-butenoic acid 31
                                                    (Z)-2-aminobutenoic acid 0
                                                    2-aminobut-2-enoic acid 0
                                                    2-hydroxy-4-(1-oxo-1,3-dihydro-2H-inden-2-ylidene) but-2-enoic acid 0
                                                    2-hydroxy-4-(2-oxo-1,3-dihydro-2H-inden-1-ylidene) but-2-enoic acid 0
                                                    2-methylbut-2-enoic acid + 0
                                                    3-methylbut-2-enoic acid + 0
                                                    but-2-enoate ester + 0
                                                    but-2-enoyl-CoA + 0
                                                    crotonic acid + 0
                                                    isocrotonic acid + 0
                                                    methyl 3-hydroxybut-2-enoate + 31
paths to the root