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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2-butenoic acid
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Accession:CHEBI:17217 term browser browse the term
Definition:A butenoic acid having the double bond at position C-2.
Synonyms:exact_synonym: but-2-enoic acid
 related_synonym: 2-Butenoate;   2-butenic acid;   3-methylacrylic acid;   CTA;   Crotonic acid;   Crotonsaeure;   Formula=C4H6O2;   InChI=1S/C4H6O2/c1-2-3-4(5)6/h2-3H,1H3,(H,5,6);   InChIKey=LDHQCZJRKDOVOX-UHFFFAOYSA-N;   SMILES=[H]C(C)=CC(O)=O;   acide crotonique;   alpha-butenoic acid;   alpha-crotonic acid;   beta-methacrylic acid;   beta-methylacrylic acid
 alt_id: CHEBI:1027;   CHEBI:19484;   CHEBI:19485
 xref: Beilstein:1098434;   CAS:3724-65-0;   Gmelin:324286;   KEGG:C01771;   Reaxys:1098434
 cyclic_relationship: is_conjugate_acid_of CHEBI:36258

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mevinphos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
decreases activity		 ISO
EXP		 [Mevinphos co-treated with Dichlorvos] results in decreased activity of ACHE protein; asoxime chloride inhibits the reaction [Mevinphos results in decreased activity of ACHE protein]; HLo 7 inhibits the reaction [Mevinphos results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [Mevinphos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Mevinphos results in decreased activity of ACHE protein] CTD PMID:4859365 PMID:8783813 PMID:21251949 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a increases expression
multiple interactions		 EXP Mevinphos results in increased expression of AGTR1A mRNA; Mevinphos results in increased expression of AGTR1A protein
[Mevinphos results in increased activity of AGTR1A protein] promotes the reaction [NOX1 protein results in increased abundance of Superoxides]		 CTD PMID:23824088 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions
increases expression		 EXP [Mevinphos results in increased activity of AGTR2 protein] which results in increased abundance of Peroxynitrous Acid
Mevinphos results in increased expression of AGTR2 mRNA; Mevinphos results in increased expression of AGTR2 protein		 CTD PMID:23824088 NCBI chr  X:119,389,480...119,393,845
Ensembl chr  X:119,390,013...119,393,842 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions		 EXP Mevinphos results in increased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Mevinphos results in increased activity of and results in increased phosphorylation of AKT1 protein]; AKT1 protein modified form affects the reaction [Mevinphos results in increased activity of RELA protein]; Mevinphos results in increased activity of and results in increased phosphorylation of AKT1 protein; PI103 inhibits the reaction [Mevinphos results in increased activity of and results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Mevinphos results in increased activity of and results in increased phosphorylation of AKT1 protein]		 CTD PMID:24462917 PMID:25449601 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions EXP ARNT protein affects the reaction [Mevinphos results in increased expression of NOS1 protein]; ARNT protein affects the reaction [Mevinphos results in increased expression of PRKG1 protein]; Mevinphos promotes the reaction [HIF1A protein binds to ARNT protein] CTD PMID:21390240 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179 		JBrowse link
G Atf2 activating transcription factor 2 increases phosphorylation EXP Mevinphos results in increased phosphorylation of ATF2 protein CTD PMID:23157661 NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
affects expression		 EXP HSPD1 protein affects the reaction [Mevinphos affects the expression of BAX protein]; Mevinphos promotes the reaction [HSPD1 protein binds to BAX protein] CTD PMID:17150954 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression
multiple interactions		 EXP Mevinphos affects the expression of BCL2 protein
HSPD1 protein affects the reaction [Mevinphos affects the expression of BCL2 protein]; Mevinphos affects the reaction [HSPD1 protein binds to BCL2 protein]		 CTD PMID:17150954 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions		 EXP Mevinphos results in increased activity of CASP3 protein
HSPD1 protein affects the reaction [Mevinphos results in increased activity of CASP3 protein]		 CTD PMID:17150954 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cep55 centrosomal protein 55 increases expression EXP Mevinphos results in increased expression of CEP55 mRNA; Mevinphos results in increased expression of CEP55 protein CTD PMID:25449601 NCBI chr 1:256,745,251...256,760,794
Ensembl chr 1:256,745,288...256,760,796 		JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 increases activity EXP Mevinphos results in increased activity of CHRM2 protein CTD PMID:17395621 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090 		JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 increases activity EXP Mevinphos results in increased activity of CHRM4 protein CTD PMID:17395621 NCBI chr 3:80,833,272...80,841,165
Ensembl chr 3:80,833,272...80,841,006 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions EXP HIF1A protein affects the reaction [Mevinphos results in increased expression of HMOX1 protein]; HIF1A protein affects the reaction [Mevinphos results in increased expression of NOS1 protein]; HIF1A protein affects the reaction [Mevinphos results in increased expression of PRKG1 protein]; Mevinphos promotes the reaction [HIF1A protein binds to ARNT protein]; Mevinphos promotes the reaction [HIF1A protein binds to SUMO1 protein]; Mevinphos results in increased expression of and affects the localization of HIF1A protein; Mevinphos results in increased expression of and results in increased activity of HIF1A protein; SUMO1 protein affects the reaction [Mevinphos results in increased expression of and results in increased activity of HIF1A protein]; UBE2I protein affects the reaction [Mevinphos results in increased expression of and results in increased activity of HIF1A protein] CTD PMID:19333137 PMID:21390240 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 EXP Mevinphos results in increased expression of HMOX1 protein
HIF1A protein affects the reaction [Mevinphos results in increased expression of HMOX1 protein]		 CTD PMID:19333137 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 increases expression EXP Mevinphos results in increased expression of HSPA9 protein CTD PMID:17150954 NCBI chr18:27,731,072...27,749,235
Ensembl chr18:27,731,072...27,749,235 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions
increases expression		 EXP HSPD1 protein affects the reaction [Mevinphos affects the expression of BAX protein]; HSPD1 protein affects the reaction [Mevinphos affects the expression of BCL2 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased activity of CASP3 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased expression of NOS1 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased expression of NOS2 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased expression of PRKG1 protein]; Mevinphos affects the reaction [HSPD1 protein binds to BCL2 protein]; Mevinphos promotes the reaction [HSPD1 protein binds to BAX protein]
Mevinphos results in increased expression of HSPD1 mRNA; Mevinphos results in increased expression of HSPD1 protein		 CTD PMID:17150954 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956 		JBrowse link
G Il2 interleukin 2 decreases response to substance ISO Mevinphos results in decreased susceptibility to IL2 protein CTD PMID:8349949 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases phosphorylation EXP Mevinphos results in increased phosphorylation of JUN protein CTD PMID:23157661 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277 		JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 increases phosphorylation EXP Mevinphos results in increased phosphorylation of MAP2K4 protein CTD PMID:23157661 NCBI chr10:52,196,121...52,301,887
Ensembl chr10:52,196,124...52,290,657 		JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 increases phosphorylation EXP Mevinphos results in increased phosphorylation of MAP2K6 protein CTD PMID:23157661 NCBI chr10:98,707,160...98,823,054
Ensembl chr10:98,706,960...98,823,287 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP methoctramine inhibits the reaction [Mevinphos affects the localization of and affects the activity of NFKB1 protein]; Mevinphos affects the localization of and affects the activity of NFKB1 protein; Tropicamide inhibits the reaction [Mevinphos affects the localization of and affects the activity of NFKB1 protein] CTD PMID:17395621 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689 		JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions
increases activity
increases expression		 EXP ARNT protein affects the reaction [Mevinphos results in increased expression of NOS1 protein]; HIF1A protein affects the reaction [Mevinphos results in increased expression of NOS1 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased expression of NOS1 protein]; KT 5720 inhibits the reaction [Mevinphos results in increased expression of NOS1 protein]; methoctramine inhibits the reaction [Mevinphos results in increased expression of NOS1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Mevinphos results in increased expression of NOS1 protein]; Tropicamide inhibits the reaction [Mevinphos results in increased expression of NOS1 protein]
Mevinphos results in increased activity of NOS1 protein
Mevinphos results in increased expression of NOS1 mRNA; Mevinphos results in increased expression of NOS1 protein		 CTD PMID:15111025 PMID:15617736 PMID:17150954 PMID:17395621 PMID:17438462 PMID:21390240 PMID:24462917 PMID:28601397 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases activity
increases expression		 EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased expression of NOS2 protein]; methoctramine inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]; PTEN protein inhibits the reaction [Mevinphos results in increased expression of NOS2 mRNA]; PTEN protein inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]; triciribine inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]; Tropicamide inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]; Wortmannin inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]
Mevinphos results in increased activity of NOS2 protein
Mevinphos results in increased expression of NOS2; Mevinphos results in increased expression of NOS2 mRNA; Mevinphos results in increased expression of NOS2 protein		 CTD PMID:15111025 PMID:15617736 PMID:17150954 PMID:17395621 PMID:21390240 PMID:24462917 PMID:25449601 PMID:28601397 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions EXP [Mevinphos results in increased activity of AGTR1A protein] promotes the reaction [NOX1 protein results in increased abundance of Superoxides] CTD PMID:23824088 NCBI chr  X:104,909,328...104,932,508
Ensembl chr  X:104,909,326...104,932,508 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 increases phosphorylation
multiple interactions		 EXP Mevinphos results in increased phosphorylation of PIK3R1 protein
PIK3R1 protein affects the reaction [Mevinphos results in increased activity of RELA protein]		 CTD PMID:24462917 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867 		JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 multiple interactions
increases expression		 EXP 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Mevinphos results in increased expression of PRKG1 protein]; 7-nitroindazole inhibits the reaction [Mevinphos results in increased expression of PRKG1 protein]; ARNT protein affects the reaction [Mevinphos results in increased expression of PRKG1 protein]; HIF1A protein affects the reaction [Mevinphos results in increased expression of PRKG1 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased expression of PRKG1 protein]
Mevinphos results in increased expression of PRKG1 mRNA; Mevinphos results in increased expression of PRKG1 protein		 CTD PMID:15617736 PMID:17150954 PMID:21390240 PMID:28601397 NCBI chr 1:248,982,039...250,300,952 JBrowse link
G Pten phosphatase and tensin homolog multiple interactions EXP Mevinphos results in increased activity of and results in decreased oxidation of PTEN protein; PTEN protein inhibits the reaction [Mevinphos results in increased expression of NOS2 mRNA]; PTEN protein inhibits the reaction [Mevinphos results in increased expression of NOS2 protein] CTD PMID:28601397 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases activity		 EXP AKT1 protein modified form affects the reaction [Mevinphos results in increased activity of RELA protein]; methoctramine inhibits the reaction [Mevinphos affects the localization of and affects the activity of RELA protein]; Mevinphos affects the localization of and affects the activity of RELA protein; PIK3R1 protein affects the reaction [Mevinphos results in increased activity of RELA protein]; triciribine inhibits the reaction [Mevinphos results in increased activity of RELA protein]; Tropicamide inhibits the reaction [Mevinphos affects the localization of and affects the activity of RELA protein]; Wortmannin inhibits the reaction [Mevinphos results in increased activity of RELA protein] CTD PMID:17395621 PMID:24462917 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Sumo1 small ubiquitin-like modifier 1 multiple interactions EXP Mevinphos promotes the reaction [HIF1A protein binds to SUMO1 protein]; SUMO1 protein affects the reaction [Mevinphos results in increased expression of and results in increased activity of HIF1A protein] CTD PMID:21390240 NCBI chr 9:66,453,428...66,483,614
Ensembl chr 9:66,453,438...66,483,614 		JBrowse link
G Ube2i ubiquitin-conjugating enzyme E2I multiple interactions EXP Mevinphos results in increased expression of and results in increased activity of UBE2I protein; UBE2I protein affects the reaction [Mevinphos results in increased expression of and results in increased activity of HIF1A protein] CTD PMID:21390240 NCBI chr10:14,618,615...14,639,274
Ensembl chr10:14,620,531...14,630,151 		JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 multiple interactions
increases expression		 EXP Cycloheximide inhibits the reaction [Mevinphos results in increased expression of UCHL1 protein]; Dactinomycin inhibits the reaction [Mevinphos results in increased expression of UCHL1 protein] CTD PMID:15545831 NCBI chr14:43,133,224...43,143,942
Ensembl chr14:43,133,218...43,143,973 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19761
    chemical entity 19761
      atom 19759
        nonmetal atom 19641
          carbon atom 19559
            organic molecular entity 19559
              lipid 17483
                fatty acid 16011
                  short-chain fatty acid 15700
                    butenoic acid 31
                      2-butenoic acid 31
                        (Z)-2-aminobutenoic acid 0
                        2-aminobut-2-enoic acid 0
                        2-hydroxy-4-(1-oxo-1,3-dihydro-2H-inden-2-ylidene) but-2-enoic acid 0
                        2-hydroxy-4-(2-oxo-1,3-dihydro-2H-inden-1-ylidene) but-2-enoic acid 0
                        2-methylbut-2-enoic acid + 0
                        3-methylbut-2-enoic acid + 0
                        but-2-enoate ester + 0
                        but-2-enoyl-CoA + 0
                        crotonic acid + 0
                        isocrotonic acid + 0
                        methyl 3-hydroxybut-2-enoate + 31
Path 2
Term Annotations click to browse term
  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    p-block element atom 19653
                      carbon group element atom 19569
                        carbon atom 19559
                          organic molecular entity 19559
                            organic group 18593
                              organic divalent group 18584
                                organodiyl group 18584
                                  carbonyl group 18499
                                    carbonyl compound 18499
                                      carboxylic acid 18151
                                        monocarboxylic acid 17523
                                          fatty acid 16011
                                            unsaturated fatty acid 949
                                              monounsaturated fatty acid 448
                                                butenoic acid 31
                                                  2-butenoic acid 31
                                                    (Z)-2-aminobutenoic acid 0
                                                    2-aminobut-2-enoic acid 0
                                                    2-hydroxy-4-(1-oxo-1,3-dihydro-2H-inden-2-ylidene) but-2-enoic acid 0
                                                    2-hydroxy-4-(2-oxo-1,3-dihydro-2H-inden-1-ylidene) but-2-enoic acid 0
                                                    2-methylbut-2-enoic acid + 0
                                                    3-methylbut-2-enoic acid + 0
                                                    but-2-enoate ester + 0
                                                    but-2-enoyl-CoA + 0
                                                    crotonic acid + 0
                                                    isocrotonic acid + 0
                                                    methyl 3-hydroxybut-2-enoate + 31
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