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G |
Ache |
acetylcholinesterase |
multiple interactions decreases activity |
ISO EXP |
[Mevinphos co-treated with Dichlorvos] results in decreased activity of ACHE protein; asoxime chloride inhibits the reaction [Mevinphos results in decreased activity of ACHE protein]; HLo 7 inhibits the reaction [Mevinphos results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [Mevinphos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Mevinphos results in decreased activity of ACHE protein] |
CTD |
PMID:4859365 PMID:8783813 PMID:21251949 |
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NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
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G |
Agtr1a |
angiotensin II receptor, type 1a |
increases expression multiple interactions |
EXP |
Mevinphos results in increased expression of AGTR1A mRNA; Mevinphos results in increased expression of AGTR1A protein [Mevinphos results in increased activity of AGTR1A protein] promotes the reaction [NOX1 protein results in increased abundance of Superoxides] |
CTD |
PMID:23824088 |
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NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
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G |
Agtr2 |
angiotensin II receptor, type 2 |
multiple interactions increases expression |
EXP |
[Mevinphos results in increased activity of AGTR2 protein] which results in increased abundance of Peroxynitrous Acid Mevinphos results in increased expression of AGTR2 mRNA; Mevinphos results in increased expression of AGTR2 protein |
CTD |
PMID:23824088 |
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NCBI chr X:119,389,480...119,393,845
Ensembl chr X:119,390,013...119,393,842
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G |
Akt1 |
AKT serine/threonine kinase 1 |
increases phosphorylation multiple interactions |
EXP |
Mevinphos results in increased phosphorylation of AKT1 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Mevinphos results in increased activity of and results in increased phosphorylation of AKT1 protein]; AKT1 protein modified form affects the reaction [Mevinphos results in increased activity of RELA protein]; Mevinphos results in increased activity of and results in increased phosphorylation of AKT1 protein; PI103 inhibits the reaction [Mevinphos results in increased activity of and results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Mevinphos results in increased activity of and results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:24462917 PMID:25449601 |
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NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
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G |
Arnt |
aryl hydrocarbon receptor nuclear translocator |
multiple interactions |
EXP |
ARNT protein affects the reaction [Mevinphos results in increased expression of NOS1 protein]; ARNT protein affects the reaction [Mevinphos results in increased expression of PRKG1 protein]; Mevinphos promotes the reaction [HIF1A protein binds to ARNT protein] |
CTD |
PMID:21390240 |
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NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
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G |
Atf2 |
activating transcription factor 2 |
increases phosphorylation |
EXP |
Mevinphos results in increased phosphorylation of ATF2 protein |
CTD |
PMID:23157661 |
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NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions affects expression |
EXP |
HSPD1 protein affects the reaction [Mevinphos affects the expression of BAX protein]; Mevinphos promotes the reaction [HSPD1 protein binds to BAX protein] |
CTD |
PMID:17150954 |
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NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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G |
Bcl2 |
BCL2, apoptosis regulator |
affects expression multiple interactions |
EXP |
Mevinphos affects the expression of BCL2 protein HSPD1 protein affects the reaction [Mevinphos affects the expression of BCL2 protein]; Mevinphos affects the reaction [HSPD1 protein binds to BCL2 protein] |
CTD |
PMID:17150954 |
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NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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G |
Casp3 |
caspase 3 |
increases activity multiple interactions |
EXP |
Mevinphos results in increased activity of CASP3 protein HSPD1 protein affects the reaction [Mevinphos results in increased activity of CASP3 protein] |
CTD |
PMID:17150954 |
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NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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G |
Cep55 |
centrosomal protein 55 |
increases expression |
EXP |
Mevinphos results in increased expression of CEP55 mRNA; Mevinphos results in increased expression of CEP55 protein |
CTD |
PMID:25449601 |
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NCBI chr 1:256,745,251...256,760,794
Ensembl chr 1:256,745,288...256,760,796
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G |
Chrm2 |
cholinergic receptor, muscarinic 2 |
increases activity |
EXP |
Mevinphos results in increased activity of CHRM2 protein |
CTD |
PMID:17395621 |
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NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090
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G |
Chrm4 |
cholinergic receptor, muscarinic 4 |
increases activity |
EXP |
Mevinphos results in increased activity of CHRM4 protein |
CTD |
PMID:17395621 |
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NCBI chr 3:80,833,272...80,841,165
Ensembl chr 3:80,833,272...80,841,006
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions |
EXP |
HIF1A protein affects the reaction [Mevinphos results in increased expression of HMOX1 protein]; HIF1A protein affects the reaction [Mevinphos results in increased expression of NOS1 protein]; HIF1A protein affects the reaction [Mevinphos results in increased expression of PRKG1 protein]; Mevinphos promotes the reaction [HIF1A protein binds to ARNT protein]; Mevinphos promotes the reaction [HIF1A protein binds to SUMO1 protein]; Mevinphos results in increased expression of and affects the localization of HIF1A protein; Mevinphos results in increased expression of and results in increased activity of HIF1A protein; SUMO1 protein affects the reaction [Mevinphos results in increased expression of and results in increased activity of HIF1A protein]; UBE2I protein affects the reaction [Mevinphos results in increased expression of and results in increased activity of HIF1A protein] |
CTD |
PMID:19333137 PMID:21390240 |
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NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
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G |
Hmox1 |
heme oxygenase 1 |
increases expression multiple interactions |
EXP |
Mevinphos results in increased expression of HMOX1 protein HIF1A protein affects the reaction [Mevinphos results in increased expression of HMOX1 protein] |
CTD |
PMID:19333137 |
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NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
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G |
Hspa9 |
heat shock protein family A (Hsp70) member 9 |
increases expression |
EXP |
Mevinphos results in increased expression of HSPA9 protein |
CTD |
PMID:17150954 |
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NCBI chr18:27,731,072...27,749,235
Ensembl chr18:27,731,072...27,749,235
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G |
Hspd1 |
heat shock protein family D (Hsp60) member 1 |
multiple interactions increases expression |
EXP |
HSPD1 protein affects the reaction [Mevinphos affects the expression of BAX protein]; HSPD1 protein affects the reaction [Mevinphos affects the expression of BCL2 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased activity of CASP3 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased expression of NOS1 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased expression of NOS2 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased expression of PRKG1 protein]; Mevinphos affects the reaction [HSPD1 protein binds to BCL2 protein]; Mevinphos promotes the reaction [HSPD1 protein binds to BAX protein] Mevinphos results in increased expression of HSPD1 mRNA; Mevinphos results in increased expression of HSPD1 protein |
CTD |
PMID:17150954 |
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NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
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G |
Il2 |
interleukin 2 |
decreases response to substance |
ISO |
Mevinphos results in decreased susceptibility to IL2 protein |
CTD |
PMID:8349949 |
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NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
increases phosphorylation |
EXP |
Mevinphos results in increased phosphorylation of JUN protein |
CTD |
PMID:23157661 |
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NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
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G |
Map2k4 |
mitogen activated protein kinase kinase 4 |
increases phosphorylation |
EXP |
Mevinphos results in increased phosphorylation of MAP2K4 protein |
CTD |
PMID:23157661 |
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NCBI chr10:52,196,121...52,301,887
Ensembl chr10:52,196,124...52,290,657
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G |
Map2k6 |
mitogen-activated protein kinase kinase 6 |
increases phosphorylation |
EXP |
Mevinphos results in increased phosphorylation of MAP2K6 protein |
CTD |
PMID:23157661 |
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NCBI chr10:98,707,160...98,823,054
Ensembl chr10:98,706,960...98,823,287
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
EXP |
methoctramine inhibits the reaction [Mevinphos affects the localization of and affects the activity of NFKB1 protein]; Mevinphos affects the localization of and affects the activity of NFKB1 protein; Tropicamide inhibits the reaction [Mevinphos affects the localization of and affects the activity of NFKB1 protein] |
CTD |
PMID:17395621 |
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NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
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G |
Nos1 |
nitric oxide synthase 1 |
multiple interactions increases activity increases expression |
EXP |
ARNT protein affects the reaction [Mevinphos results in increased expression of NOS1 protein]; HIF1A protein affects the reaction [Mevinphos results in increased expression of NOS1 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased expression of NOS1 protein]; KT 5720 inhibits the reaction [Mevinphos results in increased expression of NOS1 protein]; methoctramine inhibits the reaction [Mevinphos results in increased expression of NOS1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Mevinphos results in increased expression of NOS1 protein]; Tropicamide inhibits the reaction [Mevinphos results in increased expression of NOS1 protein] Mevinphos results in increased activity of NOS1 protein Mevinphos results in increased expression of NOS1 mRNA; Mevinphos results in increased expression of NOS1 protein |
CTD |
PMID:15111025 PMID:15617736 PMID:17150954 PMID:17395621 PMID:17438462 PMID:21390240 PMID:24462917 PMID:28601397 |
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NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions increases activity increases expression |
EXP |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased expression of NOS2 protein]; methoctramine inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]; PTEN protein inhibits the reaction [Mevinphos results in increased expression of NOS2 mRNA]; PTEN protein inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]; triciribine inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]; Tropicamide inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]; Wortmannin inhibits the reaction [Mevinphos results in increased expression of NOS2 protein] Mevinphos results in increased activity of NOS2 protein Mevinphos results in increased expression of NOS2; Mevinphos results in increased expression of NOS2 mRNA; Mevinphos results in increased expression of NOS2 protein |
CTD |
PMID:15111025 PMID:15617736 PMID:17150954 PMID:17395621 PMID:21390240 PMID:24462917 PMID:25449601 PMID:28601397 |
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NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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G |
Nox1 |
NADPH oxidase 1 |
multiple interactions |
EXP |
[Mevinphos results in increased activity of AGTR1A protein] promotes the reaction [NOX1 protein results in increased abundance of Superoxides] |
CTD |
PMID:23824088 |
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NCBI chr X:104,909,328...104,932,508
Ensembl chr X:104,909,326...104,932,508
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G |
Pik3r1 |
phosphoinositide-3-kinase regulatory subunit 1 |
increases phosphorylation multiple interactions |
EXP |
Mevinphos results in increased phosphorylation of PIK3R1 protein PIK3R1 protein affects the reaction [Mevinphos results in increased activity of RELA protein] |
CTD |
PMID:24462917 |
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NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
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G |
Prkg1 |
protein kinase cGMP-dependent 1 |
multiple interactions increases expression |
EXP |
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Mevinphos results in increased expression of PRKG1 protein]; 7-nitroindazole inhibits the reaction [Mevinphos results in increased expression of PRKG1 protein]; ARNT protein affects the reaction [Mevinphos results in increased expression of PRKG1 protein]; HIF1A protein affects the reaction [Mevinphos results in increased expression of PRKG1 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased expression of PRKG1 protein] Mevinphos results in increased expression of PRKG1 mRNA; Mevinphos results in increased expression of PRKG1 protein |
CTD |
PMID:15617736 PMID:17150954 PMID:21390240 PMID:28601397 |
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NCBI chr 1:248,982,039...250,300,952
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G |
Pten |
phosphatase and tensin homolog |
multiple interactions |
EXP |
Mevinphos results in increased activity of and results in decreased oxidation of PTEN protein; PTEN protein inhibits the reaction [Mevinphos results in increased expression of NOS2 mRNA]; PTEN protein inhibits the reaction [Mevinphos results in increased expression of NOS2 protein] |
CTD |
PMID:28601397 |
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NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions increases activity |
EXP |
AKT1 protein modified form affects the reaction [Mevinphos results in increased activity of RELA protein]; methoctramine inhibits the reaction [Mevinphos affects the localization of and affects the activity of RELA protein]; Mevinphos affects the localization of and affects the activity of RELA protein; PIK3R1 protein affects the reaction [Mevinphos results in increased activity of RELA protein]; triciribine inhibits the reaction [Mevinphos results in increased activity of RELA protein]; Tropicamide inhibits the reaction [Mevinphos affects the localization of and affects the activity of RELA protein]; Wortmannin inhibits the reaction [Mevinphos results in increased activity of RELA protein] |
CTD |
PMID:17395621 PMID:24462917 |
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NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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G |
Sumo1 |
small ubiquitin-like modifier 1 |
multiple interactions |
EXP |
Mevinphos promotes the reaction [HIF1A protein binds to SUMO1 protein]; SUMO1 protein affects the reaction [Mevinphos results in increased expression of and results in increased activity of HIF1A protein] |
CTD |
PMID:21390240 |
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NCBI chr 9:66,453,428...66,483,614
Ensembl chr 9:66,453,438...66,483,614
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G |
Ube2i |
ubiquitin-conjugating enzyme E2I |
multiple interactions |
EXP |
Mevinphos results in increased expression of and results in increased activity of UBE2I protein; UBE2I protein affects the reaction [Mevinphos results in increased expression of and results in increased activity of HIF1A protein] |
CTD |
PMID:21390240 |
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NCBI chr10:14,618,615...14,639,274
Ensembl chr10:14,620,531...14,630,151
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G |
Uchl1 |
ubiquitin C-terminal hydrolase L1 |
multiple interactions increases expression |
EXP |
Cycloheximide inhibits the reaction [Mevinphos results in increased expression of UCHL1 protein]; Dactinomycin inhibits the reaction [Mevinphos results in increased expression of UCHL1 protein] |
CTD |
PMID:15545831 |
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NCBI chr14:43,133,224...43,143,942
Ensembl chr14:43,133,218...43,143,973
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