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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2,5-dihydroxybenzoic acid
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Accession:CHEBI:17189 term browser browse the term
Definition:A dihydroxybenzoic acid having the two hydroxy groups at the 2- and 5-positions.
Synonyms:related_synonym: 2,5-Dihydroxybenzoate;   5-hydroxysalicylic acid;   Formula=C7H6O4;   Gentisate;   Gentisic acid;   Hydroquinonecarboxylic acid;   InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11);   InChIKey=WXTMDXOMEHJXQO-UHFFFAOYSA-N;   SMILES=OC(=O)c1cc(O)ccc1O
 alt_id: CHEBI:11451;   CHEBI:19381;   CHEBI:19382;   CHEBI:936
 xref: CAS:490-79-9;   Drug_Central:3260;   HMDB:HMDB0000152;   KEGG:C00628;   KNApSAcK:C00002648;   LINCS:LSM-19031
 xref_mesh: MESH:C010925
 xref: MetaCyc:CPD-633;   PDBeChem:GTQ;   PMID:15862799;   PMID:18314336;   PMID:22770225;   PMID:24547933;   Reaxys:2209119;   Wikipedia:Gentisic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:58044


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2,5-dihydroxybenzoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions ISO 2,5-dihydroxybenzoic acid inhibits the reaction [APP protein modified form binds to APP protein modified form]; Gallic Acid inhibits the reaction [2,5-dihydroxybenzoic acid inhibits the reaction [APP protein modified form binds to APP protein modified form]] CTD PMID:22129351 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Cat catalase multiple interactions ISO 2,5-dihydroxybenzoic acid inhibits the reaction [Benzoyl Peroxide results in decreased activity of CAT protein] CTD PMID:15454305 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cryz crystallin zeta multiple interactions ISO 2,5-dihydroxybenzoic acid inhibits the reaction [Benzoyl Peroxide results in decreased activity of CRYZ protein] CTD PMID:15454305 NCBI chr 2:243,552,037...243,580,369
Ensembl chr 2:243,552,119...243,579,758
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases activity
multiple interactions
ISO 2,5-dihydroxybenzoic acid results in decreased activity of G6PD protein mutant form
2,5-dihydroxybenzoic acid inhibits the reaction [Benzoyl Peroxide results in decreased activity of G6PD protein]
CTD PMID:5432368 PMID:15454305 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO 2,5-dihydroxybenzoic acid inhibits the reaction [Benzoyl Peroxide results in decreased activity of GSR protein] CTD PMID:15454305 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions ISO 2,5-dihydroxybenzoic acid inhibits the reaction [Benzoyl Peroxide results in increased activity of ODC1 protein] CTD PMID:15454305 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases activity
increases expression
ISO
EXP
2,5-dihydroxybenzoic acid results in increased activity of SULT1A1 protein
2,5-dihydroxybenzoic acid results in increased expression of SULT1A1 mRNA
CTD PMID:16308312 PMID:16443358 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 increases expression EXP 2,5-dihydroxybenzoic acid results in increased expression of SULT2A1 mRNA CTD PMID:16443358 NCBI chr 1:75,451,178...75,508,142 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      application 19471
        MALDI matrix material 949
          2,5-dihydroxybenzoic acid 8
            2,5-dihydroxybenzoic acid 2-O-beta-D-glucoside 0
            2,5-dihydroxybenzoic acid 5-O-beta-D-glucoside 0
            2,5-dihydroxybenzoyl-CoA 0
            benzyl 2,5-dihydroxybenzoate 0
            mygalin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic acid 18364
                                        aromatic carboxylic acid 11708
                                          benzoic acids 11681
                                            benzoic acid 4157
                                              hydroxybenzoic acid 3562
                                                dihydroxybenzoic acid 62
                                                  2,5-dihydroxybenzoic acid 8
                                                    2,5-dihydroxybenzoic acid 2-O-beta-D-glucoside 0
                                                    2,5-dihydroxybenzoic acid 5-O-beta-D-glucoside 0
                                                    2,5-dihydroxybenzoyl-CoA 0
                                                    benzyl 2,5-dihydroxybenzoate 0
                                                    mygalin 0
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