Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2,5-dihydroxybenzoic acid
go back to main search page
Accession:CHEBI:17189 term browser browse the term
Definition:A dihydroxybenzoic acid having the two hydroxy groups at the 2- and 5-positions.
Synonyms:related_synonym: 2,5-Dihydroxybenzoate;   5-hydroxysalicylic acid;   Formula=C7H6O4;   Gentisate;   Gentisic acid;   Hydroquinonecarboxylic acid;   InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11);   InChIKey=WXTMDXOMEHJXQO-UHFFFAOYSA-N;   SMILES=OC(=O)c1cc(O)ccc1O
 alt_id: CHEBI:11451;   CHEBI:19381;   CHEBI:19382;   CHEBI:936
 xref: CAS:490-79-9;   Drug_Central:3260;   HMDB:HMDB0000152;   KEGG:C00628;   KNApSAcK:C00002648;   LINCS:LSM-19031
 xref_mesh: MESH:C010925
 xref: MetaCyc:CPD-633;   PDBeChem:GTQ;   PMID:15862799;   PMID:18314336;   PMID:22770225;   PMID:24547933;   Reaxys:2209119;   Wikipedia:Gentisic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:58044


show annotations for term's descendants           Sort by:
2,5-dihydroxybenzoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions ISO 2,5-dihydroxybenzoic acid inhibits the reaction [APP protein modified form binds to APP protein modified form]; Gallic Acid inhibits the reaction [2,5-dihydroxybenzoic acid inhibits the reaction [APP protein modified form binds to APP protein modified form]] CTD PMID:22129351 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Cat catalase multiple interactions ISO 2,5-dihydroxybenzoic acid inhibits the reaction [Benzoyl Peroxide results in decreased activity of CAT protein] CTD PMID:15454305 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cryz crystallin zeta multiple interactions ISO 2,5-dihydroxybenzoic acid inhibits the reaction [Benzoyl Peroxide results in decreased activity of CRYZ protein] CTD PMID:15454305 NCBI chr 2:243,552,037...243,580,369
Ensembl chr 2:243,552,119...243,579,758 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases activity
multiple interactions		 ISO 2,5-dihydroxybenzoic acid results in decreased activity of G6PD protein mutant form
2,5-dihydroxybenzoic acid inhibits the reaction [Benzoyl Peroxide results in decreased activity of G6PD protein]		 CTD PMID:5432368 PMID:15454305 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO 2,5-dihydroxybenzoic acid inhibits the reaction [Benzoyl Peroxide results in decreased activity of GSR protein] CTD PMID:15454305 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions ISO 2,5-dihydroxybenzoic acid inhibits the reaction [Benzoyl Peroxide results in increased activity of ODC1 protein] CTD PMID:15454305 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases activity
increases expression		 ISO
EXP		 2,5-dihydroxybenzoic acid results in increased activity of SULT1A1 protein
2,5-dihydroxybenzoic acid results in increased expression of SULT1A1 mRNA		 CTD PMID:16308312 PMID:16443358 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 increases expression EXP 2,5-dihydroxybenzoic acid results in increased expression of SULT2A1 mRNA CTD PMID:16443358 NCBI chr 1:75,451,178...75,508,142
Ensembl chr 1:74,911,100...75,508,134 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19818
    role 19790
      application 19622
        MALDI matrix material 989
          2,5-dihydroxybenzoic acid 8
            2,5-dihydroxybenzoic acid 2-O-beta-D-glucoside 0
            2,5-dihydroxybenzoic acid 5-O-beta-D-glucoside 0
            2,5-dihydroxybenzoyl-CoA 0
            benzyl 2,5-dihydroxybenzoate 0
            mygalin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19818
    subatomic particle 19816
      composite particle 19816
        hadron 19816
          baryon 19816
            nucleon 19816
              atomic nucleus 19816
                atom 19816
                  main group element atom 19761
                    p-block element atom 19761
                      carbon group element atom 19703
                        carbon atom 19698
                          organic molecular entity 19698
                            organic group 18905
                              organic divalent group 18887
                                organodiyl group 18887
                                  carbonyl group 18853
                                    carbonyl compound 18853
                                      carboxylic acid 18569
                                        aromatic carboxylic acid 11830
                                          benzoic acids 11805
                                            benzoic acid 4374
                                              hydroxybenzoic acid 3784
                                                dihydroxybenzoic acid 69
                                                  2,5-dihydroxybenzoic acid 8
                                                    2,5-dihydroxybenzoic acid 2-O-beta-D-glucoside 0
                                                    2,5-dihydroxybenzoic acid 5-O-beta-D-glucoside 0
                                                    2,5-dihydroxybenzoyl-CoA 0
                                                    benzyl 2,5-dihydroxybenzoate 0
                                                    mygalin 0
paths to the root