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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:nucleoside 5'-monophosphate
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Accession:CHEBI:17188 term browser browse the term
Synonyms:related_synonym: Formula=C5H10O7PR;   NMP;   Nucleoside phosphate;   SMILES=O[C@H]1[C@H]([*])O[C@H](COP(O)(O)=O)[C@H]1O;   nucleoside monophosphate;   nucleoside monophosphates
 alt_id: CHEBI:14676;   CHEBI:25607;   CHEBI:7439;   CHEBI:7653;   CHEBI:7654
 xref: KEGG:C01329;   KEGG:C02520
 cyclic_relationship: is_conjugate_acid_of CHEBI:58043


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2'-deoxycytosine 5'-monophosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions
increases abundance
ISO Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Deoxycytidine Monophosphate] CTD PMID:27469509 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705
JBrowse link
2'-deoxyguanosine 5'-monophosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions
increases abundance
ISO Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of 2'-deoxyguanosine 5'-phosphate] CTD PMID:27469509 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705
JBrowse link
3'-CMP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdipt CDP-diacylglycerol--inositol 3-phosphatidyltransferase multiple interactions ISO [delta-hexachlorocyclohexane results in decreased activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate; [Inositol promotes the reaction [CDIPT protein results in increased metabolism of Cytidine Diphosphate Diglycerides]] which results in increased abundance of Cytidine Monophosphate CTD PMID:2579070 NCBI chr 1:198,409,186...198,413,497
Ensembl chr 1:198,409,360...198,413,497
JBrowse link
adenosine 5'-monophosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc9 ATP binding cassette subfamily C member 9 multiple interactions ISO Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]; Creatine metabolite inhibits the reaction [Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]] CTD PMID:11390963 NCBI chr 4:176,806,098...176,928,540
Ensembl chr 4:176,805,431...176,922,424
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 multiple interactions ISO [4-dimethylaminocinnamaldehyde co-treated with Adenosine Monophosphate] binds to ALDH1A1 protein CTD PMID:10609638 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Ercc6 ERCC excision repair 6, chromatin remodeling factor increases abundance ISO ERCC6 gene mutant form results in increased abundance of Adenosine Monophosphate CTD PMID:25440059 NCBI chr16:8,734,028...8,804,610
Ensembl chr16:8,734,035...8,804,610
JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO Adenosine Monophosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form] CTD PMID:32941855 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 multiple interactions ISO Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]; Creatine metabolite inhibits the reaction [Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]] CTD PMID:11390963 NCBI chr 1:102,103,093...102,107,134
Ensembl chr 1:102,103,094...102,106,127
JBrowse link
G Nudt11 nudix hydrolase 11 multiple interactions ISO [NUDT11 protein results in increased metabolism of diadenosine 5',5''''-P1,P6-hexaphosphate] which results in increased chemical synthesis of Adenosine Monophosphate; [NUDT11 protein results in increased metabolism of P(1),P(5)-di(adenosine-5'-)pentaphosphate] which results in increased chemical synthesis of Adenosine Monophosphate CTD PMID:12121577 NCBI chr  X:17,171,510...17,215,108
Ensembl chr  X:17,540,458...17,540,952
Ensembl chr  X:17,540,458...17,540,952
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO Adenosine Monophosphate results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 multiple interactions ISO Adenosine Monophosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of TP53BP1 protein] CTD PMID:32941855 NCBI chr 3:113,160,030...113,259,701
Ensembl chr 3:113,160,000...113,231,790
JBrowse link
G Tp73 tumor protein p73 affects abundance ISO TP73 protein affects the abundance of Adenosine Monophosphate CTD PMID:25554796 NCBI chr 5:171,355,876...171,415,354
Ensembl chr 5:171,355,876...171,415,354
JBrowse link
CMP-N-acetyl-beta-neuraminic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cmas cytidine monophosphate N-acetylneuraminic acid synthetase affects abundance ISO CMAS protein affects the abundance of Cytidine Monophosphate N-Acetylneuraminic Acid CTD PMID:27380425 NCBI chr 4:176,994,129...177,012,445
Ensembl chr 4:176,994,129...177,012,444
JBrowse link
cytidine 5'-monophosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdipt CDP-diacylglycerol--inositol 3-phosphatidyltransferase multiple interactions ISO [delta-hexachlorocyclohexane results in decreased activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate; [Inositol promotes the reaction [CDIPT protein results in increased metabolism of Cytidine Diphosphate Diglycerides]] which results in increased abundance of Cytidine Monophosphate CTD PMID:2579070 NCBI chr 1:198,409,186...198,413,497
Ensembl chr 1:198,409,360...198,413,497
JBrowse link
dTMP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions
increases abundance
ISO Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Thymidine Monophosphate] CTD PMID:27469509 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705
JBrowse link
G Tyms thymidylate synthetase multiple interactions ISO [Fluorouracil results in decreased activity of TYMS protein] which results in decreased abundance of Thymidine Monophosphate CTD PMID:29258758 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
JBrowse link
dUMP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc5 ATP binding cassette subfamily C member 5 increases export ISO ABCC5 protein results in increased export of 2'-deoxyuridylic acid CTD PMID:15897250 NCBI chr11:84,395,982...84,490,215
Ensembl chr11:84,396,033...84,490,211
JBrowse link
G Tyms thymidylate synthetase multiple interactions ISO [Fluorouracil results in decreased activity of TYMS protein] which results in increased abundance of 2'-deoxyuridylic acid CTD PMID:29258758 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
JBrowse link
FMN term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions
increases abundance
ISO Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Flavin Mononucleotide] CTD PMID:27469509 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705
JBrowse link
G Rfk riboflavin kinase increases abundance ISO RFK protein results in increased abundance of Flavin Mononucleotide CTD PMID:21308351 NCBI chr 1:236,494,221...236,501,733
Ensembl chr 1:236,494,221...236,501,733
JBrowse link
G Slc52a3 solute carrier family 52 member 3 multiple interactions EXP Flavin Mononucleotide inhibits the reaction [SLC52A3 protein results in increased transport of Riboflavin] CTD PMID:19122205 NCBI chr 3:147,503,266...147,517,935
Ensembl chr 3:147,511,406...147,516,455
JBrowse link
guanosine 5'-monophosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fut8 fucosyltransferase 8 decreases activity ISO Guanosine Monophosphate results in decreased activity of FUT8 protein CTD PMID:12770769 NCBI chr 6:100,305,957...100,537,208
Ensembl chr 6:100,337,226...100,537,224
JBrowse link
G Gmds GDP-mannose 4, 6-dehydratase affects binding ISO Guanosine Monophosphate binds to GMDS protein CTD PMID:25526675 NCBI chr17:33,408,722...33,938,086
Ensembl chr17:33,408,722...33,938,085
JBrowse link
IMP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1b interleukin 1 beta multiple interactions EXP [Inosine Monophosphate co-treated with potassium oxonate] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]; Inosine Monophosphate inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]; SCH 442416 inhibits the reaction [Inosine Monophosphate inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]] CTD PMID:20868668 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP [potassium oxonate co-treated with Inosine Monophosphate] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]; Inosine Monophosphate inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]; SCH 442416 inhibits the reaction [Inosine Monophosphate inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]] CTD PMID:20868668 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [Inosine Monophosphate co-treated with potassium oxonate] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]; Inosine Monophosphate inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]; SCH 442416 inhibits the reaction [Inosine Monophosphate inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]] CTD PMID:20868668 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp73 tumor protein p73 affects abundance ISO TP73 protein affects the abundance of Inosine Monophosphate CTD PMID:25554796 NCBI chr 5:171,355,876...171,415,354
Ensembl chr 5:171,355,876...171,415,354
JBrowse link
poly(cytidylic acid) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions
increases expression
EXP Minocycline inhibits the reaction [Poly C results in increased expression of GRIA1 mRNA] CTD PMID:19660546 NCBI chr10:42,441,723...42,760,200
Ensembl chr10:42,614,713...42,760,200
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A increases expression
multiple interactions
EXP Poly C results in increased expression of GRIN2A mRNA
Minocycline inhibits the reaction [Poly C results in increased expression of GRIN2A mRNA]
CTD PMID:19660546 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990
JBrowse link
G Grin2c glutamate ionotropic receptor NMDA type subunit 2C multiple interactions
increases expression
EXP Minocycline inhibits the reaction [Poly C results in increased expression of GRIN2C mRNA] CTD PMID:19660546 NCBI chr10:103,798,290...103,816,923
Ensembl chr10:103,798,291...103,816,287
JBrowse link
G Il1b interleukin 1 beta increases expression EXP Poly C results in increased expression of IL1B protein CTD PMID:19660546 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
poly(guanylic acid) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP Poly G inhibits the reaction [Particulate Matter results in increased expression of ACTA2 mRNA]; Poly G inhibits the reaction [Particulate Matter results in increased expression of ACTA2 protein]; Poly G inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 mRNA]; Poly G inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein] CTD PMID:30391304 PMID:31028789 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Atf6 activating transcription factor 6 multiple interactions EXP Poly G inhibits the reaction [Silicon Dioxide results in increased expression of ATF6 protein] CTD PMID:31028789 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
JBrowse link
G Casp12 caspase 12 multiple interactions EXP Poly G inhibits the reaction [Silicon Dioxide results in increased expression of CASP12 protein] CTD PMID:31028789 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
JBrowse link
G Cdh1 cadherin 1 multiple interactions EXP Poly G inhibits the reaction [Particulate Matter results in decreased expression of CDH1 mRNA]; Poly G inhibits the reaction [Particulate Matter results in decreased expression of CDH1 protein]; Poly G inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 mRNA]; Poly G inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 protein] CTD PMID:30391304 PMID:31028789 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP Poly G inhibits the reaction [Particulate Matter results in increased expression of COL1A1 mRNA]; Poly G inhibits the reaction [Silicon Dioxide results in increased expression of COL1A1 mRNA] CTD PMID:30391304 PMID:31028789 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions EXP Poly G inhibits the reaction [Particulate Matter results in increased expression of COL3A1 mRNA]; Poly G inhibits the reaction [Silicon Dioxide results in increased expression of COL3A1 mRNA] CTD PMID:30391304 PMID:31028789 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions EXP Poly G inhibits the reaction [Silicon Dioxide results in increased expression of DDIT3 protein] CTD PMID:31028789 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions EXP Poly G inhibits the reaction [Silicon Dioxide results in increased expression of ERN1 protein] CTD PMID:31028789 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Poly G inhibits the reaction [Silicon Dioxide results in increased expression of HSPA5 protein] CTD PMID:31028789 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Marco macrophage receptor with collagenous structure multiple interactions ISO
EXP
Poly G inhibits the reaction [MARCO protein binds to and results in increased uptake of Polystyrenes]
Poly G inhibits the reaction [Particulate Matter results in increased expression of MARCO protein]; Poly G inhibits the reaction [Silicon Dioxide results in increased expression of MARCO protein]
CTD PMID:17361018 PMID:30391304 PMID:31028789 NCBI chr16:85,115,199...85,147,683
Ensembl chr16:85,115,201...85,135,859
JBrowse link
G Vim vimentin multiple interactions EXP Poly G inhibits the reaction [Particulate Matter results in increased expression of VIM mRNA]; Poly G inhibits the reaction [Particulate Matter results in increased expression of VIM protein]; Poly G inhibits the reaction [Silicon Dioxide results in increased expression of VIM mRNA]; Poly G inhibits the reaction [Silicon Dioxide results in increased expression of VIM protein] CTD PMID:30391304 PMID:31028789 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
poly(I:C) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd2 abhydrolase domain containing 2, acylglycerol lipase multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of ABHD2 mRNA CTD PMID:26923065 NCBI chr 1:140,998,240...141,087,405
Ensembl chr 1:140,998,240...141,087,405
JBrowse link
G Ablim1 actin-binding LIM protein 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of ABLIM1 mRNA CTD PMID:26923065 NCBI chr 1:277,853,877...278,043,096 JBrowse link
G Acads acyl-CoA dehydrogenase short chain multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of ACADS mRNA CTD PMID:26923065 NCBI chr12:47,254,503...47,263,747
Ensembl chr12:47,254,484...47,263,747
JBrowse link
G Adam10 ADAM metallopeptidase domain 10 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of ADAM10 mRNA CTD PMID:26923065 NCBI chr 8:77,107,355...77,237,483
Ensembl chr 8:77,107,536...77,237,483
JBrowse link
G Ahcyl1 adenosylhomocysteinase-like 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of AHCYL1 mRNA CTD PMID:26923065 NCBI chr 2:210,438,884...210,474,350
Ensembl chr 2:210,438,893...210,473,761
JBrowse link
G Ahr aryl hydrocarbon receptor increases expression ISO Poly I-C results in increased expression of AHR mRNA; Poly I-C results in increased expression of AHR protein CTD PMID:27783115 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akap5 A-kinase anchoring protein 5 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of AKAP5 mRNA CTD PMID:26923065 NCBI chr 6:99,356,509...99,361,909
Ensembl chr 6:99,356,509...99,361,909
JBrowse link
G App amyloid beta precursor protein multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of APP mRNA CTD PMID:26923065 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Appl1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 increases degradation
multiple interactions
ISO Poly I-C results in increased degradation of APPL1 protein
APPL1 protein inhibits the reaction [Poly I-C results in increased expression of IL1B protein]; APPL1 protein inhibits the reaction [Poly I-C results in increased expression of TNF protein]; APPL1 protein promotes the reaction [Poly I-C results in increased expression of CCL5 mRNA]; APPL1 protein promotes the reaction [Poly I-C results in increased expression of CXCL10 mRNA]; APPL1 protein promotes the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; APPL1 protein promotes the reaction [Poly I-C results in increased phosphorylation of IKBKE protein]; APPL1 protein promotes the reaction [Poly I-C results in increased phosphorylation of IRF3 protein]; APPL1 protein promotes the reaction [Poly I-C results in increased phosphorylation of TBK1 protein]; bafilomycin A1 promotes the reaction [Poly I-C results in increased degradation of APPL1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Poly I-C results in increased degradation of APPL1 protein]; Chloroquine inhibits the reaction [Poly I-C results in increased degradation of APPL1 protein]; trametinib inhibits the reaction [Poly I-C results in increased degradation of APPL1 protein]; U 0126 inhibits the reaction [Poly I-C results in increased degradation of APPL1 protein]
CTD PMID:25780039 NCBI chr16:2,560,103...2,602,035
Ensembl chr16:2,563,520...2,602,103
JBrowse link
G Arc activity-regulated cytoskeleton-associated protein affects methylation EXP Poly I-C affects the methylation of ARC promoter CTD PMID:32843831 NCBI chr 7:115,907,097...115,911,059
Ensembl chr 7:115,907,097...115,910,541
JBrowse link
G Arfgef3 ARFGEF family member 3 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of ARFGEF3 mRNA CTD PMID:26923065 NCBI chr 1:13,837,861...13,918,277
Ensembl chr 1:13,838,707...13,915,594
JBrowse link
G Arg2 arginase 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of ARG2 mRNA CTD PMID:26923065 NCBI chr 6:102,311,097...102,338,406
Ensembl chr 6:102,311,116...102,338,520
JBrowse link
G Arhgap11a Rho GTPase activating protein 11A multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of ARHGAP11A mRNA CTD PMID:26923065 NCBI chr 3:105,281,827...105,298,108
Ensembl chr 3:105,281,827...105,298,108
JBrowse link
G Arhgap44 Rho GTPase activating protein 44 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of ARHGAP44 mRNA CTD PMID:26923065 NCBI chr10:51,501,547...51,669,546
Ensembl chr10:51,502,894...51,669,297
JBrowse link
G Arhgap9 Rho GTPase activating protein 9 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of ARHGAP9 mRNA CTD PMID:26923065 NCBI chr 7:70,612,650...70,620,900
Ensembl chr 7:70,612,103...70,620,890
JBrowse link
G Arhgef12 Rho guanine nucleotide exchange factor 12 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of ARHGEF12 mRNA CTD PMID:26923065 NCBI chr 8:47,259,377...47,393,042
Ensembl chr 8:47,259,404...47,393,503
JBrowse link
G Arhgef7 Rho guanine nucleotide exchange factor 7 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of ARHGEF7 mRNA CTD PMID:26923065 NCBI chr16:83,006,732...83,117,065
Ensembl chr16:83,006,718...83,132,785
JBrowse link
G Arsb arylsulfatase B multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of ARSB mRNA CTD PMID:26923065 NCBI chr 2:23,385,154...23,543,028
Ensembl chr 2:23,385,183...23,544,963
JBrowse link
G Art3 ADP-ribosyltransferase 3 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of ART3 mRNA CTD PMID:26923065 NCBI chr14:17,143,037...17,225,389
Ensembl chr14:17,143,040...17,225,389
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Poly I-C results in increased expression of ATF3 mRNA CTD PMID:27783115 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atp2b2 ATPase plasma membrane Ca2+ transporting 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of ATP2B2 mRNA CTD PMID:26923065 NCBI chr 4:145,704,779...145,948,997
Ensembl chr 4:145,703,046...146,016,325
JBrowse link
G Atxn3 ataxin 3 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of ATXN3 mRNA CTD PMID:26923065 NCBI chr 6:125,817,420...125,853,461
Ensembl chr 6:125,819,640...125,853,461
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Poly I-C results in increased expression of BAX protein CTD PMID:21418039 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Poly I-C results in decreased expression of BCL2 protein CTD PMID:21418039 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2a1 BCL2-related protein A1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of BCL2A1 mRNA CTD PMID:26923065 NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
affects methylation
ISO
EXP
[Poly I-C results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine] which results in increased expression of BDNF mRNA; Poly I-C promotes the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of BDNF mRNA]
Poly I-C affects the methylation of BDNF promoter
CTD PMID:24889602 PMID:32843831 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Bid BH3 interacting domain death agonist decreases expression ISO Poly I-C results in decreased expression of BID protein CTD PMID:21418039 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO Poly I-C promotes the reaction [arsenic trioxide results in decreased expression of BIRC5 protein] CTD PMID:21418039 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Birc6 baculoviral IAP repeat-containing 6 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of BIRC6 mRNA CTD PMID:26923065 NCBI chr 6:21,900,763...22,092,484
Ensembl chr 6:21,950,100...22,092,346
JBrowse link
G Blmh bleomycin hydrolase multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of BLMH mRNA CTD PMID:26923065 NCBI chr10:63,197,367...63,240,447
Ensembl chr10:63,197,364...63,240,332
JBrowse link
G Brms1l BRMS1 like transcriptional repressor multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of BRMS1L mRNA CTD PMID:26923065 NCBI chr 6:76,675,399...76,708,261
NCBI chr 6:76,743,243...76,753,950
Ensembl chr 6:76,675,418...76,708,261
Ensembl chr 6:76,675,418...76,708,261
JBrowse link
G Brox BRO1 domain and CAAX motif containing multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of BROX mRNA CTD PMID:26923065 NCBI chr13:101,677,896...101,697,743
Ensembl chr13:101,677,902...101,697,684
JBrowse link
G C1qtnf7 C1q and TNF related 7 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of C1QTNF7 mRNA CTD PMID:26923065 NCBI chr14:72,011,518...72,122,257
Ensembl chr14:72,011,461...72,122,158
JBrowse link
G Ca3 carbonic anhydrase 3 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of CA3 mRNA CTD PMID:26923065 NCBI chr 2:88,126,519...88,136,063
Ensembl chr 2:88,126,667...88,135,410
JBrowse link
G Cage1 cancer antigen 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of CAGE1 mRNA CTD PMID:26923065 NCBI chr17:27,452,506...27,490,853
Ensembl chr17:27,452,638...27,490,851
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO Acetylcysteine inhibits the reaction [arsenic trioxide promotes the reaction [Poly I-C results in increased activity of CASP3 protein]]; Acetylcysteine inhibits the reaction [Poly I-C promotes the reaction [arsenic trioxide results in increased activity of CASP3 protein]]; arsenic trioxide promotes the reaction [Poly I-C results in increased activity of CASP3 protein]; Poly I-C promotes the reaction [arsenic trioxide results in increased activity of CASP3 protein] CTD PMID:21418039 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity
ISO arsenic trioxide promotes the reaction [Poly I-C results in increased activity of CASP8 protein]; Poly I-C promotes the reaction [arsenic trioxide results in increased activity of CASP8 protein] CTD PMID:21418039 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
ISO Acetylcysteine inhibits the reaction [arsenic trioxide promotes the reaction [Poly I-C results in increased activity of CASP9 protein]]; Acetylcysteine inhibits the reaction [Poly I-C promotes the reaction [arsenic trioxide results in increased activity of CASP9 protein]]; arsenic trioxide promotes the reaction [Poly I-C results in increased activity of CASP9 protein]; Poly I-C promotes the reaction [arsenic trioxide results in increased activity of CASP9 protein] CTD PMID:21418039 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase decreases expression EXP Poly I-C results in decreased expression of CAT mRNA CTD PMID:23939143 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cav1 caveolin 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of CAV1 mRNA CTD PMID:26923065 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Cbx1 chromobox 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of CBX1 mRNA CTD PMID:26923065 NCBI chr10:84,656,698...84,677,112
Ensembl chr10:84,669,914...84,675,741
JBrowse link
G Cbx6 chromobox 6 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of CBX6 mRNA CTD PMID:26923065 NCBI chr 7:121,047,996...121,058,109
Ensembl chr 7:121,050,302...121,058,029
JBrowse link
G Ccdc113 coiled-coil domain containing 113 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of CCDC113 mRNA CTD PMID:26923065 NCBI chr19:9,912,124...9,932,183
Ensembl chr19:9,912,183...9,931,930
JBrowse link
G Ccl1 C-C motif chemokine ligand 1 increases expression ISO Poly I-C results in increased expression of CCL1 mRNA CTD PMID:27783115 NCBI chr10:69,534,976...69,537,836
Ensembl chr10:69,534,933...69,537,882
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 multiple interactions
increases secretion
ISO methyldithiocarbamate inhibits the reaction [Poly I-C results in increased secretion of CCL11 protein] CTD PMID:24056979 NCBI chr10:69,434,965...69,439,566
Ensembl chr10:69,434,941...69,439,575
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression
increases secretion
ISO
EXP
methyldithiocarbamate inhibits the reaction [Poly I-C results in increased secretion of CCL2 protein]
Poly I-C results in increased expression of CCL2 mRNA
CTD PMID:23939143 PMID:24056979 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions
increases expression
ISO Ethanol inhibits the reaction [Poly I-C results in increased expression of CCL3 protein] CTD PMID:19500611 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 multiple interactions
increases expression
increases secretion
ISO Ethanol inhibits the reaction [Poly I-C results in increased expression of CCL4 protein]; methyldithiocarbamate inhibits the reaction [Poly I-C results in increased secretion of CCL4 protein]
6-formylindolo(3,2-b)carbazole inhibits the reaction [Poly I-C results in increased expression of CCL4 mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [Poly I-C results in increased expression of CCL4 mRNA]
CTD PMID:19500611 PMID:24056979 PMID:27783115 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions
increases expression
increases secretion
ISO APPL1 protein promotes the reaction [Poly I-C results in increased expression of CCL5 mRNA]; methyldithiocarbamate inhibits the reaction [Poly I-C results in increased secretion of CCL5 protein]; trametinib promotes the reaction [Poly I-C results in increased expression of CCL5 mRNA]
Poly I-C results in increased expression of CCL5; Poly I-C results in increased expression of CCL5 mRNA
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; [Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; IL4 protein promotes the reaction [Poly I-C results in increased expression of CCL5 mRNA]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; Particulate Matter inhibits the reaction [Poly I-C results in increased expression of CCL5]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; Vehicle Emissions inhibits the reaction [Poly I-C results in increased expression of CCL5]
CTD PMID:23688403 PMID:24056979 PMID:24709138 PMID:25780039 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Cd40 CD40 molecule increases expression
multiple interactions
ISO Poly I-C results in increased expression of CD40 protein
[Poly I-C co-treated with IFNG protein] results in increased secretion of CD40 protein
CTD PMID:15246609 PMID:16224278 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
JBrowse link
G Cd80 Cd80 molecule increases expression ISO Poly I-C results in increased expression of CD80 protein CTD PMID:15246609 NCBI chr11:64,815,201...64,855,293
Ensembl chr11:64,827,635...64,855,353
JBrowse link
G Cd83 CD83 molecule increases expression
multiple interactions
ISO Poly I-C results in increased expression of CD83 protein
CEP-11004 inhibits the reaction [Poly I-C results in increased expression of CD83 protein]; SB 203580 inhibits the reaction [Poly I-C results in increased expression of CD83 protein]
CTD PMID:17698565 NCBI chr17:24,416,651...24,435,790
Ensembl chr17:24,416,651...24,435,790
JBrowse link
G Cd86 CD86 molecule multiple interactions
increases expression
ISO [Poly I-C co-treated with IFNG protein] results in increased secretion of CD86 protein; CEP-11004 inhibits the reaction [Poly I-C results in increased expression of CD86 protein]; Particulate Matter analog inhibits the reaction [Poly I-C results in increased expression of CD86 protein]; SB 203580 inhibits the reaction [Poly I-C results in increased expression of CD86 protein]; Vehicle Emissions analog inhibits the reaction [Poly I-C results in increased expression of CD86 protein] CTD PMID:15246609 PMID:16224278 PMID:16890772 PMID:17698565 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Cdx2 caudal type homeo box 2 multiple interactions ISO [Poly I-C co-treated with 6-formylindolo(3,2-b)carbazole] results in increased expression of CDX2 mRNA; [Poly I-C co-treated with Tetrachlorodibenzodioxin] results in increased expression of CDX2 mRNA CTD PMID:27783115 NCBI chr12:9,464,026...9,470,565
Ensembl chr12:9,464,026...9,470,565
JBrowse link
G Celf1 CUGBP, Elav-like family member 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of CELF1 mRNA CTD PMID:26923065 NCBI chr 3:79,768,900...79,844,548
Ensembl chr 3:79,823,945...79,842,082
JBrowse link
G Cfp complement factor properdin multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of CFP mRNA CTD PMID:26923065 NCBI chr  X:1,311,121...1,316,683
Ensembl chr  X:1,311,121...1,316,682
JBrowse link
G Chsy1 chondroitin sulfate synthase 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of CHSY1 mRNA CTD PMID:26923065 NCBI chr 1:127,010,587...127,071,570
Ensembl chr 1:127,010,588...127,071,570
JBrowse link
G Cibar2 CBY1 interacting BAR domain containing 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of CIBAR2 mRNA CTD PMID:26923065 NCBI chr19:53,740,763...53,754,738
Ensembl chr19:53,743,383...53,754,602
JBrowse link
G Clcc1 chloride channel CLIC-like 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of CLCC1 mRNA CTD PMID:26923065 NCBI chr 2:211,450,426...211,479,885
Ensembl chr 2:211,450,484...211,479,884
JBrowse link
G Clec14a C-type lectin domain containing 14A multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of CLEC14A mRNA CTD PMID:26923065 NCBI chr 6:79,303,301...79,306,443
Ensembl chr 6:79,303,304...79,306,443
JBrowse link
G Clip3 CAP-GLY domain containing linker protein 3 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of CLIP3 mRNA CTD PMID:26923065 NCBI chr 1:88,750,453...88,766,453
Ensembl chr 1:90,962,707...90,978,907
JBrowse link
G Cnnm1 cyclin and CBS domain divalent metal cation transport mediator 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of CNNM1 mRNA CTD PMID:26923065 NCBI chr 1:263,184,361...263,243,912
Ensembl chr 1:263,186,235...263,242,468
JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions EXP Cannabidiol inhibits the reaction [Poly I-C inhibits the reaction [Rimonabant binds to CNR1 protein]]; Poly I-C inhibits the reaction [Rimonabant binds to CNR1 protein] CTD PMID:31202911 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
G Cnr2 cannabinoid receptor 2 increases expression EXP Poly I-C results in increased expression of CNR2 mRNA CTD PMID:27317300 NCBI chr 5:154,242,010...154,268,126
Ensembl chr 5:154,260,062...154,268,126
JBrowse link
G Cntn1 contactin 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of CNTN1 mRNA CTD PMID:26923065 NCBI chr 7:133,290,606...133,588,314
Ensembl chr 7:133,400,485...133,586,677
JBrowse link
G Crabp1 cellular retinoic acid binding protein 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of CRABP1 mRNA CTD PMID:26923065 NCBI chr 8:59,344,097...59,352,135
Ensembl chr 8:59,344,083...59,352,132
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions
increases expression
ISO Ethanol inhibits the reaction [Poly I-C results in increased expression of CSF2 protein] CTD PMID:19500611 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Cttnbp2 cortactin binding protein 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of CTTNBP2 mRNA CTD PMID:26923065 NCBI chr 4:42,932,897...43,096,454
Ensembl chr 4:42,932,903...43,096,399
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression EXP Poly I-C results in increased expression of CXCL1 mRNA CTD PMID:23939143 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions
increases expression
ISO
EXP
APPL1 protein promotes the reaction [Poly I-C results in increased expression of CXCL10 mRNA]; chrysin inhibits the reaction [Poly I-C results in increased expression of CXCL10 mRNA]; eriodictyol inhibits the reaction [Poly I-C results in increased expression of CXCL10 mRNA]; Luteolin inhibits the reaction [Poly I-C results in increased expression of CXCL10 mRNA]; Quercetin inhibits the reaction [Poly I-C results in increased expression of CXCL10 mRNA]; trametinib promotes the reaction [Poly I-C results in increased expression of CXCL10 mRNA]
cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester inhibits the reaction [Poly I-C results in increased expression of CXCL10 mRNA]
Poly I-C results in increased expression of CXCL10 mRNA; Poly I-C results in increased expression of CXCL10 protein
[Dronabinol co-treated with Cannabidiol] inhibits the reaction [Poly I-C results in increased expression of CXCL10 protein]; [Pam(3)CSK(4) peptide co-treated with Antigens, Bacterial co-treated with Poly I-C co-treated with Lipopolysaccharides co-treated with FSL-1 lipoprotein, synthetic co-treated with Imiquimod co-treated with Polyribonucleotides co-treated with ProMune] results in increased expression of CXCL10 protein; bafilomycin A1 inhibits the reaction [Poly I-C results in increased expression of CXCL10 protein]; Cannabidiol inhibits the reaction [Poly I-C results in increased expression of CXCL10 mRNA]; Cannabidiol inhibits the reaction [Poly I-C results in increased expression of CXCL10 protein]; Chloroquine inhibits the reaction [Poly I-C results in increased expression of CXCL10 protein]; Dronabinol inhibits the reaction [Poly I-C results in increased expression of CXCL10 mRNA]; Dronabinol inhibits the reaction [Poly I-C results in increased expression of CXCL10 protein]; Particulate Matter inhibits the reaction [[Pam(3)CSK(4) peptide co-treated with Antigens, Bacterial co-treated with Poly I-C co-treated with Lipopolysaccharides co-treated with FSL-1 lipoprotein, synthetic co-treated with Imiquimod co-treated with Polyribonucleotides co-treated with ProMune] results in increased expression of CXCL10 protein]; Phosphorothioate Oligonucleotides inhibits the reaction [Poly I-C results in increased expression of CXCL10 protein]; Smoke inhibits the reaction [Poly I-C results in increased expression of CXCL10 protein]; Vehicle Emissions inhibits the reaction [[Pam(3)CSK(4) peptide co-treated with Antigens, Bacterial co-treated with Poly I-C co-treated with Lipopolysaccharides co-treated with FSL-1 lipoprotein, synthetic co-treated with Imiquimod co-treated with Polyribonucleotides co-treated with ProMune] results in increased expression of CXCL10 protein]
CTD PMID:19426678 PMID:25780039 PMID:26682054 PMID:28003376 PMID:28572013 PMID:28655636 PMID:28726298 PMID:32244040 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression EXP Poly I-C results in increased expression of CXCL2 mRNA CTD PMID:23939143 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions
increases expression
ISO Ethanol inhibits the reaction [Poly I-C results in increased expression of CXCL1 protein] CTD PMID:19500611 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 multiple interactions
increases secretion
increases expression
ISO Luteolin inhibits the reaction [Poly I-C results in increased expression of CXCL9 mRNA]; methyldithiocarbamate inhibits the reaction [Poly I-C results in increased secretion of CXCL9 protein] CTD PMID:19426678 PMID:24056979 NCBI chr14:17,228,832...17,233,743
Ensembl chr14:17,228,856...17,234,712
JBrowse link
G Cyfip2 cytoplasmic FMR1 interacting protein 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of CYFIP2 mRNA CTD PMID:26923065 NCBI chr10:31,278,746...31,419,235
Ensembl chr10:31,278,746...31,419,235
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Poly I-C promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA] CTD PMID:27783115 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases expression EXP Poly I-C results in decreased expression of CYP2C11 mRNA CTD PMID:23939143 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases expression EXP Poly I-C results in decreased expression of CYP2C6V1 mRNA CTD PMID:23939143 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2c7 cytochrome P450, family 2, subfamily c, polypeptide 7 decreases expression EXP Poly I-C results in decreased expression of CYP2C7 mRNA CTD PMID:23939143 NCBI chr 1:147,422,999...148,119,979
Ensembl chr 1:148,053,687...148,119,857
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 decreases expression EXP Poly I-C results in decreased expression of CYP3A23-3A1 mRNA CTD PMID:23939143 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyria CYFIP related Rac1 interactor A multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of CYRIA mRNA CTD PMID:26923065 NCBI chr 6:37,555,167...37,661,196
Ensembl chr 6:37,555,182...37,665,064
JBrowse link
G Cysrt1 cysteine rich tail 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of CYSRT1 mRNA CTD PMID:26923065 NCBI chr 3:2,458,295...2,462,037
Ensembl chr 3:2,458,295...2,459,385
JBrowse link
G Dab1 DAB adaptor protein 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of DAB1 mRNA CTD PMID:26923065 NCBI chr 5:123,154,360...124,279,170
Ensembl chr 5:123,905,166...124,280,115
JBrowse link
G Dck deoxycytidine kinase multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of DCK mRNA CTD PMID:26923065 NCBI chr14:20,935,442...20,952,939
Ensembl chr14:20,935,369...20,953,095
JBrowse link
G Dcun1d3 defective in cullin neddylation 1 domain containing 3 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of DCUN1D3 mRNA CTD PMID:26923065 NCBI chr 1:189,626,442...189,666,440
Ensembl chr 1:189,627,972...189,666,440
JBrowse link
G Dcun1d4 defective in cullin neddylation 1 domain containing 4 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of DCUN1D4 mRNA CTD PMID:26923065 NCBI chr14:37,210,721...37,294,517
Ensembl chr14:37,210,721...37,294,472
JBrowse link
G Ddx3x DEAD-box helicase 3, X-linked multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of DDX3X mRNA CTD PMID:26923065 NCBI chr  X:10,400,363...10,414,010
Ensembl chr  X:10,400,366...10,413,995
JBrowse link
G Ddx58 DEXD/H-box helicase 58 increases expression
multiple interactions
ISO Poly I-C results in increased expression of DDX58 mRNA
IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of DDX58 mRNA]; Nicotine inhibits the reaction [Poly I-C results in increased expression of DDX58 mRNA]
CTD PMID:27183587 PMID:30341573 PMID:31154625 NCBI chr 5:56,486,584...56,536,898
Ensembl chr 5:56,500,734...56,536,772
JBrowse link
G Defb4 defensin beta 4 increases secretion ISO Poly I-C results in increased secretion of DEFB4 protein CTD PMID:17669408 NCBI chr16:75,634,598...75,637,789
Ensembl chr16:75,634,598...75,637,789
JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of DLG1 mRNA CTD PMID:26923065 NCBI chr11:72,164,566...72,378,895
Ensembl chr11:72,163,749...72,378,895
JBrowse link
G Dnm2 dynamin 2 multiple interactions ISO DNM2 protein promotes the reaction [Poly I-C results in increased phosphorylation of IRF3 protein] CTD PMID:25780039 NCBI chr 8:22,458,869...22,540,649
Ensembl chr 8:22,458,899...22,540,524
JBrowse link
G Eea1 early endosome antigen 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of EEA1 mRNA CTD PMID:26923065 NCBI chr 7:37,101,415...37,186,534
Ensembl chr 7:37,018,459...37,186,732
JBrowse link
G Egr1 early growth response 1 multiple interactions
affects methylation
ISO
EXP
[Poly I-C results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine] which results in increased expression of EGR1 mRNA; Poly I-C promotes the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of EGR1 mRNA]
Poly I-C affects the methylation of EGR1 promoter
CTD PMID:24889602 PMID:32843831 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 increases expression
increases response to substance
ISO Poly I-C results in increased expression of EIF2AK2 mRNA
EIF2AK2 results in increased susceptibility to Poly I-C
CTD PMID:10944112 PMID:17669408 PMID:22558189 NCBI chr 6:1,428,845...1,466,193
Ensembl chr 6:1,428,834...1,466,201
JBrowse link
G Epc2l1 enhancer of polycomb homolog 2 (Drosophila)-like 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of EPC2L1 mRNA CTD PMID:26923065 NCBI chr 1:83,435,507...83,438,226 JBrowse link
G F11r F11 receptor multiple interactions
decreases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Poly I-C results in decreased expression of F11R protein]; CpG ODN 2006 inhibits the reaction [Poly I-C results in decreased expression of F11R protein]; N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [Poly I-C results in decreased expression of F11R protein]; RTKI cpd inhibits the reaction [Poly I-C results in decreased expression of F11R protein]; SB 203580 inhibits the reaction [Poly I-C results in decreased expression of F11R protein] CTD PMID:20932985 NCBI chr13:89,826,272...89,850,151
Ensembl chr13:89,826,254...89,850,612
JBrowse link
G Fabp4 fatty acid binding protein 4 increases expression ISO Poly I-C results in increased expression of FABP4 mRNA CTD PMID:15705927 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Fam107a family with sequence similarity 107, member A multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of FAM107A mRNA CTD PMID:26923065 NCBI chr15:18,399,145...18,415,959
Ensembl chr15:18,399,515...18,415,965
JBrowse link
G Fmr1 FMRP translational regulator 1 multiple interactions
decreases expression
ISO Suramin inhibits the reaction [Poly I-C results in decreased expression of FMR1 protein] CTD PMID:23516405 NCBI chr  X:154,684,924...154,722,369
Ensembl chr  X:154,684,935...154,722,314
JBrowse link
G Fxyd3 FXYD domain-containing ion transport regulator 3 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of FXYD3 mRNA CTD PMID:26923065 NCBI chr 1:89,502,561...89,510,146
Ensembl chr 1:89,502,562...89,509,343
JBrowse link
G Fyttd1 forty-two-three domain containing 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of FYTTD1 mRNA CTD PMID:26923065 NCBI chr11:71,113,931...71,136,694
Ensembl chr11:71,116,579...71,136,673
JBrowse link
G G3bp2 G3BP stress granule assembly factor 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of G3BP2 mRNA CTD PMID:26923065 NCBI chr14:17,437,145...17,523,254
Ensembl chr14:17,492,081...17,520,792
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of GABRA1 mRNA CTD PMID:26923065 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of GABRB2 mRNA CTD PMID:26923065 NCBI chr10:27,973,694...28,193,072
Ensembl chr10:27,973,681...28,187,565
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of GABRG2 mRNA CTD PMID:26923065 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
G Gad1 glutamate decarboxylase 1 decreases expression
multiple interactions
EXP Poly I-C results in decreased expression of GAD1 protein
Cannabidiol inhibits the reaction [Poly I-C results in decreased expression of GAD1 protein]
CTD PMID:31202911 NCBI chr 3:56,861,440...56,902,139
Ensembl chr 3:56,861,396...56,902,157
JBrowse link
G Gdap1 ganglioside-induced differentiation-associated-protein 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of GDAP1 mRNA CTD PMID:26923065 NCBI chr 5:1,328,963...1,347,946
Ensembl chr 5:1,328,913...1,347,921
JBrowse link
G Gdi1 GDP dissociation inhibitor 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of GDI1 mRNA CTD PMID:26923065 NCBI chr  X:156,400,734...156,407,396
Ensembl chr  X:156,400,736...156,407,404
JBrowse link
G Get3 guided entry of tail-anchored proteins factor 3, ATPase multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of GET3 mRNA CTD PMID:26923065 NCBI chr19:26,133,024...26,142,637
Ensembl chr19:26,133,027...26,141,111
JBrowse link
G Gfap glial fibrillary acidic protein increases expression EXP Poly I-C results in increased expression of GFAP mRNA CTD PMID:27317300 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Gh1 growth hormone 1 decreases expression ISO Poly I-C results in decreased expression of GH protein CTD PMID:21195166 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180
JBrowse link
G Glce glucuronic acid epimerase multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of GLCE mRNA CTD PMID:26923065 NCBI chr 8:67,006,588...67,073,723
Ensembl chr 8:67,006,592...67,040,005
JBrowse link
G Glrb glycine receptor, beta multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of GLRB mRNA CTD PMID:26923065 NCBI chr 2:179,768,040...179,842,612
Ensembl chr 2:179,769,009...179,842,547
JBrowse link
G Glyr1 glyoxylate reductase 1 homolog multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of GLYR1 mRNA CTD PMID:26923065 NCBI chr10:10,725,830...10,759,471
Ensembl chr10:10,725,819...10,761,279
JBrowse link
G Gmfb glia maturation factor, beta multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of GMFB mRNA CTD PMID:26923065 NCBI chr15:23,597,846...23,611,541
Ensembl chr15:23,601,368...23,606,634
JBrowse link
G Gmppb GDP-mannose pyrophosphorylase B multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of GMPPB mRNA CTD PMID:26923065 NCBI chr 8:116,826,251...116,856,159
Ensembl chr 8:116,826,680...116,856,159
JBrowse link
G Gpatch2l G patch domain containing 2-like multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of GPATCH2L mRNA CTD PMID:26923065 NCBI chr 6:110,093,767...110,228,943
Ensembl chr 6:110,093,819...110,227,475
JBrowse link
G Gpbp1 GC-rich promoter binding protein 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of GPBP1 mRNA CTD PMID:26923065 NCBI chr 2:43,002,041...43,070,236
Ensembl chr 2:43,002,044...43,068,677
JBrowse link
G Gsr glutathione-disulfide reductase decreases expression EXP Poly I-C results in decreased expression of GSR mRNA CTD PMID:23939143 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gzmb granzyme B multiple interactions
increases expression
ISO Particulate Matter inhibits the reaction [Poly I-C results in increased expression of GZMB mRNA]; Particulate Matter inhibits the reaction [Poly I-C results in increased expression of GZMB protein]; Vehicle Emissions inhibits the reaction [Poly I-C results in increased expression of GZMB mRNA]; Vehicle Emissions inhibits the reaction [Poly I-C results in increased expression of GZMB protein]
Poly I-C results in increased expression of GZMB mRNA; Poly I-C results in increased expression of GZMB protein
CTD PMID:23618096 NCBI chr15:35,413,862...35,417,293
Ensembl chr15:35,413,793...35,417,316
JBrowse link
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of HEY2 mRNA CTD PMID:26923065 NCBI chr 1:29,191,170...29,201,257
Ensembl chr 1:29,191,192...29,201,531
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
EXP Diclofenac promotes the reaction [Poly I-C results in increased expression of HMOX1 mRNA] CTD PMID:23939143 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 increases expression EXP Poly I-C results in increased expression of HSP90AA1 mRNA CTD PMID:23939143 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression EXP Poly I-C results in increased expression of HSPA1A mRNA CTD PMID:23939143 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression EXP Poly I-C results in increased expression of HSPA8 mRNA CTD PMID:23939143 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A increases expression ISO Poly I-C results in increased expression of HTR2A mRNA CTD PMID:24889602 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Ibtk inhibitor of Bruton tyrosine kinase multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of IBTK mRNA CTD PMID:26923065 NCBI chr 8:93,323,454...93,397,044
Ensembl chr 8:93,324,476...93,390,305
JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 increases expression
multiple interactions
ISO Poly I-C results in increased expression of IDO1 mRNA
poly(I:C) co-treated with tryptophan or alone increases activity and expression of IDO1 protein in Langerhans cell-like dendritic cells
CTD PMID:27783115, PMID:26198597 RGD:11528429 NCBI chr16:72,216,326...72,228,098
Ensembl chr16:72,216,326...72,228,098
JBrowse link
G Ido2 indoleamine 2,3-dioxygenase 2 increases expression ISO Poly I-C results in increased expression of IDO2 mRNA CTD PMID:27783115 NCBI chr16:72,232,852...72,291,227
Ensembl chr16:72,268,943...72,289,156
JBrowse link
G Ifih1 interferon induced with helicase C domain 1 increases expression
multiple interactions
ISO Poly I-C results in increased expression of IFIH1 mRNA
IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of IFIH1 mRNA]; Nicotine inhibits the reaction [Poly I-C results in increased expression of IFIH1 mRNA]
CTD PMID:30341573 PMID:31154625 NCBI chr 3:48,557,696...48,604,097
Ensembl chr 3:48,557,696...48,604,097
JBrowse link
G Ifna1 interferon, alpha 1 increases expression EXP Poly I-C results in increased expression of IFNA1 mRNA CTD PMID:28726298 NCBI chr 5:106,951,822...106,952,908
Ensembl chr 5:106,952,082...106,952,792
JBrowse link
G Ifnb1 interferon beta 1 increases expression
increases secretion
multiple interactions
ISO
EXP
Poly I-C results in increased expression of IFNB1 mRNA; Poly I-C results in increased expression of IFNB1 protein
Poly I-C results in increased secretion of IFNB1 protein
MIR26A mRNA inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]
APPL1 protein promotes the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; BX795 inhibits the reaction [Poly I-C results in increased expression of IFNB1 protein]; Luteolin inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; pitavastatin inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; Pravastatin inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; Progesterone inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; Resveratrol inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; sodium arsenite inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; sodium arsenite inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein]; Sodium Selenite inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; trametinib promotes the reaction [Poly I-C results in increased expression of IFNB1 mRNA]
[Dronabinol co-treated with Cannabidiol] inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; [Vehicle Emissions analog co-treated with Poly I-C] results in increased expression of IFNB1 mRNA; Cannabidiol inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; Dronabinol inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; IRF7 protein affects the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; IRF7 protein mutant form affects the reaction [Nicotine inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]]; IRF7 protein mutant form inhibits the reaction [Nicotine inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein]]; IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein]; Nicotine inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; Nicotine inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein]; Smoke inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; TLR3 protein affects the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; TP53 protein affects the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; Wortmannin inhibits the reaction [[Vehicle Emissions analog co-treated with Poly I-C] results in increased expression of IFNB1 mRNA]
CTD PMID:16116226 PMID:16399790 PMID:17669408 PMID:18279804 PMID:18323514 PMID:18779317 PMID:19426678 PMID:21418039 PMID:22546503 PMID:22558189 PMID:24423102 PMID:25780039 PMID:28572013 PMID:28726298 PMID:30726814 PMID:31154625 PMID:32244040 NCBI chr 5:106,865,192...106,865,746
Ensembl chr 5:106,865,192...106,865,746
JBrowse link
G Ifng interferon gamma multiple interactions
increases secretion
increases expression
ISO
EXP
[Poly I-C co-treated with IFNG protein] results in increased secretion of CD40 protein; [Poly I-C co-treated with IFNG protein] results in increased secretion of CD86 protein; Smoke inhibits the reaction [Poly I-C results in increased expression of IFNG mRNA]
Poly I-C results in increased secretion of IFNG protein
Ethanol inhibits the reaction [Poly I-C results in increased expression of IFNG protein]
Poly I-C results in increased expression of IFNG mRNA; Poly I-C results in increased expression of IFNG protein
CTD PMID:9328138 PMID:16224278 PMID:17321468 PMID:19500611 PMID:23618096 PMID:23939143 PMID:28572013 PMID:30836164 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions
decreases expression
ISO IL6 protein affects the reaction [Poly I-C results in decreased expression of IGF1 protein]
Poly I-C results in decreased expression of IGF1 mRNA; Poly I-C results in decreased expression of IGF1 protein
CTD PMID:1705203 PMID:21195166 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 multiple interactions
decreases expression
ISO IL6 protein affects the reaction [Poly I-C results in decreased expression of IGFBP3 protein] CTD PMID:21195166 NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374
JBrowse link
G Igsf6 immunoglobulin superfamily, member 6 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of IGSF6 mRNA CTD PMID:26923065 NCBI chr 1:190,997,029...191,007,503
Ensembl chr 1:190,997,029...191,007,503
JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon multiple interactions
increases phosphorylation
ISO APPL1 protein promotes the reaction [Poly I-C results in increased phosphorylation of IKBKE protein] CTD PMID:25780039 NCBI chr13:48,031,325...48,056,394
Ensembl chr13:48,031,410...48,056,394
JBrowse link
G Il10 interleukin 10 multiple interactions
increases expression
increases secretion
ISO
EXP
CEP-11004 inhibits the reaction [Poly I-C results in increased secretion of IL10 protein]; SB 203580 inhibits the reaction [Poly I-C results in increased secretion of IL10 protein]
Poly I-C results in increased expression of IL10 mRNA
Poly I-C results in increased expression of IL10 mRNA; Poly I-C results in increased expression of IL10 protein
Citrinin inhibits the reaction [Poly I-C results in increased expression of IL10 mRNA]; Citrinin inhibits the reaction [Poly I-C results in increased expression of IL10 protein]
CTD PMID:16224278 PMID:17698565 PMID:22771370 PMID:23618096 PMID:23939143 PMID:30836164 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il12a interleukin 12A multiple interactions
increases expression
ISO 6-formylindolo(3,2-b)carbazole inhibits the reaction [Poly I-C results in increased expression of IL12A mRNA]; indole-3-carbinol inhibits the reaction [Poly I-C results in increased expression of IL12A mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [Poly I-C results in increased expression of IL12A mRNA] CTD PMID:27783115 NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318
JBrowse link
G Il12b interleukin 12B multiple interactions
increases expression
ISO [[Poly I-C binds to and results in increased activity of TLR3 protein] which co-treated with Nanotubes, Carbon] results in increased secretion of IL12B protein; Particulate Matter analog inhibits the reaction [Poly I-C results in increased expression of IL12B protein]; Vehicle Emissions analog inhibits the reaction [Poly I-C results in increased expression of IL12B protein]
Poly I-C results in increased expression of IL12B mRNA; Poly I-C results in increased expression of IL12B protein
Ethanol inhibits the reaction [Poly I-C results in increased expression of IL12B protein]; Luteolin inhibits the reaction [Poly I-C results in increased expression of IL12B mRNA]
CTD PMID:16890772 PMID:19426678 PMID:19500611 PMID:23266719 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il17a interleukin 17A increases expression ISO Poly I-C results in increased expression of IL17A protein CTD PMID:30836164 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases secretion
increases expression
ISO
EXP
APPL1 protein inhibits the reaction [Poly I-C results in increased expression of IL1B protein]; Citrinin inhibits the reaction [Poly I-C results in increased expression of IL1B mRNA]; Ethanol inhibits the reaction [Poly I-C results in increased expression of IL1B protein]; Poly I-C promotes the reaction [deoxynivalenol results in increased expression of IL1B mRNA]
Poly I-C results in increased secretion of IL1B protein
2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane promotes the reaction [Poly I-C results in increased expression of IL1B protein]; 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol promotes the reaction [Poly I-C results in increased expression of IL1B protein]; 6-formylindolo(3,2-b)carbazole promotes the reaction [Poly I-C results in increased expression of IL1B mRNA]; Estradiol promotes the reaction [Poly I-C results in increased expression of IL1B protein]; Tetrachlorodibenzodioxin promotes the reaction [Poly I-C results in increased expression of IL1B mRNA]
Poly I-C results in increased expression of IL1B mRNA; Poly I-C results in increased expression of IL1B protein
CTD PMID:16687389 PMID:17321468 PMID:19500611 PMID:22771370 PMID:23618096 PMID:23939143 PMID:25780039 PMID:27783115 PMID:28316773 PMID:30017638 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 increases expression
increases secretion
ISO Poly I-C results in increased expression of IL2 mRNA
Poly I-C results in increased secretion of IL2 protein
CTD PMID:9328138 PMID:23618096 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il27 interleukin 27 increases expression
multiple interactions
ISO Poly I-C results in increased expression of IL27 mRNA
Luteolin inhibits the reaction [Poly I-C results in increased expression of IL27 mRNA]
CTD PMID:19426678 NCBI chr 1:198,003,615...198,010,112
Ensembl chr 1:198,003,683...198,008,893
JBrowse link
G Il33 interleukin 33 increases expression
multiple interactions
ISO Poly I-C results in increased expression of IL33 protein
N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Poly I-C results in increased expression of IL33 protein]
2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane promotes the reaction [Poly I-C results in increased expression of IL33 protein]; 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol promotes the reaction [Poly I-C results in increased expression of IL33 protein]; Estradiol promotes the reaction [Poly I-C results in increased expression of IL33 protein]
CTD PMID:25747661 PMID:30017638 NCBI chr 1:248,112,611...248,147,030
Ensembl chr 1:248,132,090...248,147,029
JBrowse link
G Il4 interleukin 4 multiple interactions
increases expression
increases secretion
increases response to substance
ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol promotes the reaction [Poly I-C results in increased expression of IL4 protein]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; [Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2; [Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2; [Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein; [Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA; [Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA; [Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA; [Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein; [Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprost; [Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone; [Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; amorolfine promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; butenafine promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone]; Estradiol promotes the reaction [Poly I-C results in increased expression of IL4 protein]; helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; IL4 protein promotes the reaction [Poly I-C results in increased expression of CCL5 mRNA]; IL4 protein promotes the reaction [Poly I-C results in increased expression of CXCL8 mRNA]; IL4 protein promotes the reaction [Poly I-C results in increased expression of TSLP mRNA]; IL4 protein promotes the reaction [Poly I-C results in increased expression of TSLP protein]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; Itraconazole promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; Ketoconazole promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; luliconazole promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone]; Particulate Matter inhibits the reaction [Poly I-C results in increased secretion of IL4 protein]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; Terbinafine promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone]; Vehicle Emissions inhibits the reaction [Poly I-C results in increased secretion of IL4 protein]
IL4 protein results in increased susceptibility to Poly I-C
CTD PMID:23618096 PMID:23688403 PMID:30017638 PMID:30836164 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 multiple interactions
increases secretion
increases expression
ISO
EXP
[Vehicle Emissions analog co-treated with Poly I-C] results in increased secretion of IL6 protein; CEP-11004 inhibits the reaction [Poly I-C results in increased secretion of IL6 protein]; Particulate Matter promotes the reaction [Poly I-C results in increased expression of IL6]; SB 203580 inhibits the reaction [Poly I-C results in increased secretion of IL6 protein]; TLR3 mRNA promotes the reaction [Poly I-C results in increased expression of IL6 mRNA]; TRAF6 mutant form inhibits the reaction [Vehicle Emissions analog promotes the reaction [Poly I-C results in increased expression of IL6 mRNA]]; Vehicle Emissions analog promotes the reaction [Poly I-C results in increased expression of IL6 mRNA]; Vehicle Emissions promotes the reaction [Poly I-C results in increased expression of IL6]
Poly I-C results in increased expression of IL6 mRNA; Poly I-C results in increased expression of IL6 protein
Ethanol inhibits the reaction [Poly I-C results in increased expression of IL6 protein]; IL6 protein affects the reaction [Poly I-C results in decreased expression of IGF1 protein]; IL6 protein affects the reaction [Poly I-C results in decreased expression of IGFBP3 protein]; IL6 protein affects the reaction [Poly I-C results in increased expression of PRL2B1 mRNA]; IL6 protein affects the reaction [Poly I-C results in increased phosphorylation of and results in increased activity of STAT3 protein]; Luteolin inhibits the reaction [Poly I-C results in increased expression of IL6 mRNA]; pitavastatin inhibits the reaction [Poly I-C results in increased expression of IL6 mRNA]; Poly I-C promotes the reaction [deoxynivalenol results in increased expression of IL6 mRNA]; Pravastatin inhibits the reaction [Poly I-C results in increased expression of IL6 mRNA]; sodium arsenite inhibits the reaction [Poly I-C results in increased expression of IL6 mRNA]
Poly I-C results in increased expression of IL6; Poly I-C results in increased expression of IL6 mRNA
CTD PMID:9328138 PMID:16399790 PMID:16687389 PMID:17698565 PMID:18323514 PMID:19426678 PMID:19500611 PMID:21195166 PMID:23939143 PMID:24709138 PMID:26160521 PMID:28316773 PMID:30341573 PMID:30726814 PMID:30836164 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Irf3 interferon regulatory factor 3 increases phosphorylation
affects localization
multiple interactions
ISO Poly I-C results in increased phosphorylation of IRF3 protein
Poly I-C affects the localization of IRF3 protein
APPL1 protein promotes the reaction [Poly I-C results in increased phosphorylation of IRF3 protein]; BX795 inhibits the reaction [Poly I-C results in increased phosphorylation of IRF3 protein]; Chloroquine inhibits the reaction [Poly I-C results in increased phosphorylation of IRF3 protein]; chrysin inhibits the reaction [Poly I-C results in increased expression of IRF3 mRNA]; DNM2 protein promotes the reaction [Poly I-C results in increased phosphorylation of IRF3 protein]; eriodictyol inhibits the reaction [Poly I-C results in increased expression of IRF3 mRNA]; Quercetin inhibits the reaction [Poly I-C results in increased expression of IRF3 mRNA]; Sodium Selenite inhibits the reaction [Poly I-C results in increased activity of IRF3 protein]
[Dronabinol co-treated with Cannabidiol] inhibits the reaction [Poly I-C affects the localization of IRF3 protein]; [Vehicle Emissions analog co-treated with Poly I-C] affects the localization of IRF3 protein; Cannabidiol inhibits the reaction [Poly I-C affects the localization of IRF3 protein]; Dronabinol inhibits the reaction [Poly I-C results in increased localization of IRF3 protein]; TP53 protein affects the reaction [Poly I-C results in increased phosphorylation of IRF3 protein]
CTD PMID:16399790 PMID:18279804 PMID:18779317 PMID:19426678 PMID:25780039 PMID:32244040 NCBI chr 1:100,992,244...100,997,202
Ensembl chr 1:100,992,405...100,997,198
JBrowse link
G Irf7 interferon regulatory factor 7 multiple interactions
increases expression
ISO
EXP
IRF7 protein affects the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; IRF7 protein mutant form affects the reaction [Nicotine inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]]; IRF7 protein mutant form inhibits the reaction [Nicotine inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein]]; IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of DDX58 mRNA]; IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of IFIH1 mRNA]; IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of IFIT1 mRNA]; IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of IRF7 mRNA]; IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of IRF9 mRNA]; IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of ISG15 mRNA]; IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of OAS1 mRNA]; IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of STAT1 mRNA]; IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of STAT2 mRNA]; IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein]; Nicotine inhibits the reaction [Poly I-C results in increased expression of IRF7 mRNA]
cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester inhibits the reaction [Poly I-C results in increased expression of IRF7 mRNA]
CTD PMID:28726298 PMID:31154625 NCBI chr 1:214,249,388...214,252,909
Ensembl chr 1:214,248,837...214,252,456
JBrowse link
G Irf9 interferon regulatory factor 9 multiple interactions
increases expression
ISO IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of IRF9 mRNA] CTD PMID:31154625 NCBI chr15:34,282,936...34,288,981
Ensembl chr15:34,282,936...34,288,138
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier increases expression
multiple interactions
ISO Poly I-C results in increased expression of ISG15 mRNA
IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of ISG15 mRNA]; Nicotine inhibits the reaction [Poly I-C results in increased expression of ISG15 mRNA]
CTD PMID:31154625 NCBI chr 5:173,624,862...173,629,124
Ensembl chr 5:173,624,310...173,626,248
JBrowse link
G Itgam integrin subunit alpha M increases expression EXP Poly I-C results in increased expression of ITGAM mRNA; Poly I-C results in increased expression of ITGAM protein CTD PMID:27317300 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Jcad junctional cadherin 5 associated multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of JCAD mRNA CTD PMID:26923065 NCBI chr17:55,667,754...55,709,738
Ensembl chr17:55,670,331...55,709,740
JBrowse link
G Kcna2 potassium voltage-gated channel subfamily A member 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of KCNA2 mRNA CTD PMID:26923065 NCBI chr 2:209,838,607...209,852,471
Ensembl chr 2:209,838,869...209,852,471
JBrowse link
G Kcnip4 potassium voltage-gated channel interacting protein 4 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of KCNIP4 mRNA CTD PMID:26923065 NCBI chr14:65,549,362...66,749,181
Ensembl chr14:66,598,259...66,749,178
JBrowse link
G Kcnq5 potassium voltage-gated channel subfamily Q member 5 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of KCNQ5 mRNA CTD PMID:26923065 NCBI chr 9:27,565,869...28,141,114
Ensembl chr 9:27,562,959...27,761,733
JBrowse link
G Kif5b kinesin family member 5B multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of KIF5B mRNA CTD PMID:26923065 NCBI chr17:54,181,416...54,219,048
Ensembl chr17:54,181,419...54,212,096
JBrowse link
G Kif5c kinesin family member 5C multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of KIF5C mRNA CTD PMID:26923065 NCBI chr 3:35,014,157...35,257,417
Ensembl chr 3:35,014,538...35,257,407
JBrowse link
G Klf4 Kruppel like factor 4 increases expression
multiple interactions
ISO Poly I-C results in increased expression of KLF4 protein
Poly I-C promotes the reaction [MSI1 protein results in increased expression of KLF4 protein]
CTD PMID:29486283 NCBI chr 5:72,283,311...72,287,669
Ensembl chr 5:72,283,313...72,287,669
JBrowse link
G Klrk1 killer cell lectin like receptor K1 increases expression ISO Poly I-C results in increased expression of KLRK1 mRNA; Poly I-C results in increased expression of KLRK1 protein CTD PMID:16472598 NCBI chr 4:163,392,652...163,403,735
Ensembl chr 4:163,393,217...163,403,653
JBrowse link
G Kpna3 karyopherin subunit alpha 3 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of KPNA3 mRNA CTD PMID:26923065 NCBI chr15:41,696,356...41,770,112
Ensembl chr15:41,698,281...41,770,112
JBrowse link
G Lsm14b LSM family member 14B multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of LSM14B mRNA CTD PMID:26923065 NCBI chr 3:175,408,433...175,419,180
Ensembl chr 3:175,408,629...175,417,610
JBrowse link
G Mal2 mal, T-cell differentiation protein 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of MAL2 mRNA CTD PMID:26923065 NCBI chr 7:94,130,852...94,163,649
Ensembl chr 7:94,130,852...94,163,645
JBrowse link
G Map3k11 mitogen-activated protein kinase kinase kinase 11 increases phosphorylation ISO Poly I-C results in increased phosphorylation of MAP3K11 protein CTD PMID:17698565 NCBI chr 1:221,043,119...221,056,420
Ensembl chr 1:221,043,119...221,056,417
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
increases phosphorylation
multiple interactions
ISO Poly I-C results in decreased phosphorylation of MAPK1 protein
Poly I-C results in increased phosphorylation of MAPK1 protein
Suramin inhibits the reaction [Poly I-C results in decreased phosphorylation of MAPK1 protein]; trametinib inhibits the reaction [Poly I-C results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Poly I-C results in increased phosphorylation of MAPK1 protein]
CTD PMID:23516405 PMID:25780039 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
increases phosphorylation
multiple interactions
ISO Poly I-C results in decreased phosphorylation of MAPK3 protein
Poly I-C results in increased phosphorylation of MAPK3 protein
Suramin inhibits the reaction [Poly I-C results in decreased phosphorylation of MAPK3 protein]; trametinib inhibits the reaction [Poly I-C results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Poly I-C results in increased phosphorylation of MAPK3 protein]
CTD PMID:23516405 PMID:25780039 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk4 mitogen-activated protein kinase 4 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of MAPK4 mRNA CTD PMID:26923065 NCBI chr18:69,894,692...70,043,634
Ensembl chr18:69,894,684...69,944,632
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of MAPK9 mRNA CTD PMID:26923065 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mapre1 microtubule-associated protein, RP/EB family, member 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of MAPRE1 mRNA CTD PMID:26923065 NCBI chr 3:149,221,346...149,249,469
Ensembl chr 3:149,221,377...149,249,273
JBrowse link
G Marchf7 membrane associated ring-CH-type finger 7 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of MARCHF7 mRNA CTD PMID:26923065 NCBI chr 3:46,284,961...46,325,230
Ensembl chr 3:46,286,712...46,324,057
JBrowse link
G Mblac2 metallo-beta-lactamase domain containing 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of MBLAC2 mRNA CTD PMID:26923065 NCBI chr 2:9,578,501...9,621,297
Ensembl chr 2:9,578,345...9,623,513
JBrowse link
G Mbp myelin basic protein multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of MBP mRNA CTD PMID:26923065 NCBI chr18:79,326,738...79,437,310
Ensembl chr18:79,326,738...79,437,310
JBrowse link
G Mef2c myocyte enhancer factor 2C multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of MEF2C mRNA CTD PMID:26923065 NCBI chr 2:11,658,534...11,822,788
Ensembl chr 2:11,658,568...11,822,787
JBrowse link
G Micos13 mitochondrial contact site and cristae organizing system subunit 13 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of MICOS13 mRNA CTD PMID:26923065 NCBI chr 9:10,446,567...10,449,566
Ensembl chr 9:10,446,699...10,449,566
JBrowse link
G Micu3 mitochondrial calcium uptake family, member 3 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of MICU3 mRNA CTD PMID:26923065 NCBI chr16:55,043,051...55,133,080
Ensembl chr16:55,045,619...55,132,191
JBrowse link
G Mir155 microRNA 155 multiple interactions
increases expression
ISO MIR155 mRNA inhibits the reaction [Progesterone inhibits the reaction [Poly I-C results in increased expression of MIR155 mRNA]]; Progesterone inhibits the reaction [Poly I-C results in increased expression of MIR155 mRNA] CTD PMID:22546503 NCBI chr11:24,176,603...24,176,667
Ensembl chr11:24,176,603...24,176,667
JBrowse link
G Mir26a microRNA 26a multiple interactions EXP MIR26A mRNA inhibits the reaction [Poly I-C results in increased activity of TLR3 protein]; MIR26A mRNA inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; MIR26A mRNA inhibits the reaction [Poly I-C results in increased expression of TNF mRNA]; MIR26A mRNA inhibits the reaction [Poly I-C results in increased expression of TNF protein] CTD PMID:24423102 NCBI chr 8:127,714,441...127,714,530
Ensembl chr 8:127,714,441...127,714,530
JBrowse link
G Mrps15 mitochondrial ribosomal protein S15 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of MRPS15 mRNA CTD PMID:26923065 NCBI chr 5:144,054,452...144,065,045
Ensembl chr 5:144,054,452...144,065,045
JBrowse link
G Msi1 musashi RNA-binding protein 1 multiple interactions ISO Poly I-C promotes the reaction [MSI1 protein results in increased expression of KLF4 protein]; Poly I-C promotes the reaction [MSI1 protein results in increased expression of MYC protein]; Poly I-C promotes the reaction [MSI1 protein results in increased expression of POU5F1 protein]; Poly I-C promotes the reaction [MSI1 protein results in increased expression of SOX2 protein] CTD PMID:29486283 NCBI chr12:46,899,835...46,935,335
Ensembl chr12:46,895,447...46,920,952
JBrowse link
G Mtpn myotrophin multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of MTPN mRNA CTD PMID:26923065 NCBI chr 4:63,012,009...63,039,422
Ensembl chr 4:63,012,011...63,039,422
JBrowse link
G Mtrex Mtr4 exosome RNA helicase multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of MTREX mRNA CTD PMID:26923065 NCBI chr 2:44,726,716...44,787,013
Ensembl chr 2:44,717,781...44,786,963
JBrowse link
G Mx1 MX dynamin like GTPase 1 increases expression ISO Poly I-C results in increased expression of MX1 mRNA CTD PMID:17669408 PMID:22558189 NCBI chr11:37,891,150...37,916,775
Ensembl chr11:37,891,156...37,914,983
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
increases expression
ISO Poly I-C promotes the reaction [MSI1 protein results in increased expression of MYC protein]
Poly I-C results in increased expression of MYC protein
CTD PMID:29486283 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor increases expression
multiple interactions
ISO Poly I-C results in increased expression of MYD88 mRNA
cinnamic aldehyde inhibits the reaction [Poly I-C results in increased expression of MYD88 mRNA]
CTD PMID:18306459 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841
JBrowse link
G Naa60 N(alpha)-acetyltransferase 60, NatF catalytic subunit multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of NAA60 mRNA CTD PMID:26923065 NCBI chr10:11,881,635...11,902,139
Ensembl chr10:11,881,739...11,901,785
JBrowse link
G Napb NSF attachment protein beta multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of NAPB mRNA CTD PMID:26923065 NCBI chr 3:143,017,571...143,063,904
Ensembl chr 3:143,020,454...143,063,983
JBrowse link
G Napepld N-acyl phosphatidylethanolamine phospholipase D multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of NAPEPLD mRNA CTD PMID:26923065 NCBI chr 4:9,965,323...10,004,650
Ensembl chr 4:9,966,891...10,002,247
JBrowse link
G Nbea neurobeachin multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of NBEA mRNA CTD PMID:26923065 NCBI chr 2:145,011,648...145,513,439 JBrowse link
G Ndst3 N-deacetylase and N-sulfotransferase 3 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of NDST3 mRNA CTD PMID:26923065 NCBI chr 2:227,736,491...227,903,657
Ensembl chr 2:227,738,650...227,890,077
JBrowse link
G Necab1 N-terminal EF-hand calcium binding protein 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of NECAB1 mRNA CTD PMID:26923065 NCBI chr 5:28,507,596...28,737,556
Ensembl chr 5:28,504,558...28,737,719
JBrowse link
G Nfkbia NFKB inhibitor alpha increases phosphorylation
multiple interactions
ISO Poly I-C results in increased phosphorylation of NFKBIA protein
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; [Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [Poly I-C results in increased phosphorylation of NFKBIA protein]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; TP53 protein affects the reaction [Poly I-C results in increased phosphorylation of NFKBIA protein]
CTD PMID:18779317 PMID:20932985 PMID:23688403 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nlgn3 neuroligin 3 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of NLGN3 mRNA CTD PMID:26923065 NCBI chr  X:71,199,390...71,227,460
Ensembl chr  X:71,199,491...71,222,732
JBrowse link
G Nmu neuromedin U multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of NMU mRNA CTD PMID:26923065 NCBI chr14:34,353,683...34,381,968
Ensembl chr14:34,354,503...34,381,828
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
ISO
EXP
pitavastatin inhibits the reaction [Poly I-C results in increased expression of NOS2 mRNA]; Pravastatin inhibits the reaction [Poly I-C results in increased expression of NOS2 mRNA]; sodium arsenite inhibits the reaction [Poly I-C results in increased expression of NOS2 mRNA]; sodium arsenite inhibits the reaction [Poly I-C results in increased expression of NOS2 protein]; Sodium Selenite inhibits the reaction [Poly I-C results in increased expression of NOS2 protein]
Diclofenac promotes the reaction [Poly I-C results in increased expression of NOS2 mRNA]
Poly I-C results in increased expression of NOS2 mRNA; Poly I-C results in increased expression of NOS2 protein
CTD PMID:17321468 PMID:18279804 PMID:18323514 PMID:21195166 PMID:23939143 PMID:30726814 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nrsn1 neurensin 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of NRSN1 mRNA CTD PMID:26923065 NCBI chr17:41,798,767...41,816,346
Ensembl chr17:41,798,783...41,817,101
JBrowse link
G Nuf2 NUF2 component of NDC80 kinetochore complex multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of NUF2 mRNA CTD PMID:26923065 NCBI chr13:87,818,456...87,847,223
Ensembl chr13:87,818,391...87,847,263
JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A increases expression
multiple interactions
ISO Poly I-C results in increased expression of OAS1 mRNA
[[Poly I-C co-treated with Interferon-alpha] results in increased activity of OAS1 protein] which results in increased abundance of 2',5'-oligoadenylate; [Poly I-C co-treated with Interferon-alpha] results in increased activity of OAS1 protein; IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of OAS1 mRNA]; Nicotine inhibits the reaction [Poly I-C results in increased expression of OAS1 mRNA]
CTD PMID:17669408 PMID:26055709 PMID:31154625 NCBI chr12:41,200,680...41,211,393
Ensembl chr12:41,200,718...41,211,909
JBrowse link
G Oas2 2'-5' oligoadenylate synthetase 2 increases expression ISO Poly I-C results in increased expression of OAS2 mRNA CTD PMID:22558189 NCBI chr12:41,341,417...41,363,124
Ensembl chr12:41,340,815...41,363,161
JBrowse link
G Olr1644 olfactory receptor 1644 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of OLR1644 mRNA CTD PMID:26923065 NCBI chr15:28,908,132...28,917,980
Ensembl chr15:28,906,980...28,918,162
JBrowse link
G P2rx7 purinergic receptor P2X 7 decreases expression
multiple interactions
ISO Poly I-C results in decreased expression of P2RX7 protein
Suramin inhibits the reaction [Poly I-C results in decreased expression of P2RX7 protein]
CTD PMID:23516405 NCBI chr12:39,353,613...39,396,042
Ensembl chr12:39,353,613...39,396,042
JBrowse link
G P2ry2 purinergic receptor P2Y2 decreases expression
multiple interactions
ISO Poly I-C results in decreased expression of P2RY2 protein
Suramin inhibits the reaction [Poly I-C results in decreased expression of P2RY2 protein]
CTD PMID:23516405 NCBI chr 1:166,031,228...166,045,423
Ensembl chr 1:166,031,272...166,037,424
JBrowse link
G Pak2 p21 (RAC1) activated kinase 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of PAK2 mRNA CTD PMID:26923065 NCBI chr11:72,829,407...72,865,815
Ensembl chr11:72,829,238...72,865,902
Ensembl chr11:72,829,238...72,865,902
JBrowse link
G Pard6g par-6 family cell polarity regulator gamma multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of PARD6G mRNA CTD PMID:26923065 NCBI chr18:76,559,877...76,627,843
Ensembl chr18:76,559,811...76,628,041
JBrowse link
G Pcmtd1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of PCMTD1 mRNA CTD PMID:26923065 NCBI chr 5:12,132,657...12,204,376
Ensembl chr 5:12,132,657...12,199,283
JBrowse link
G Pdap1 PDGFA associated protein 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of PDAP1 mRNA CTD PMID:26923065 NCBI chr12:11,240,775...11,251,002
Ensembl chr12:11,240,761...11,251,004
JBrowse link
G Pdcd6ip programmed cell death 6 interacting protein multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of PDCD6IP mRNA CTD PMID:26923065 NCBI chr 8:121,916,233...121,973,145
Ensembl chr 8:121,916,185...121,973,125
JBrowse link
G Pdha1l1 pyruvate dehydrogenase (lipoamide) alpha 1-like 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of PDHA1L1 mRNA CTD PMID:26923065 NCBI chr16:88,344,440...88,347,335
Ensembl chr16:88,345,247...88,347,369
JBrowse link
G Phactr1 phosphatase and actin regulator 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of PHACTR1 mRNA CTD PMID:26923065 NCBI chr17:23,245,423...23,761,207 JBrowse link
G Phf7 PHD finger protein 7 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of PHF7 mRNA CTD PMID:26923065 NCBI chr16:7,323,527...7,336,609
Ensembl chr16:7,323,520...7,336,335
JBrowse link
G Pkib cAMP-dependent protein kinase inhibitor beta multiple interactions
decreases expression
EXP [Poly I-C co-treated with HU 211] results in decreased expression of PKIB mRNA
Poly I-C results in decreased expression of PKIB mRNA
CTD PMID:26923065 NCBI chr20:40,616,868...40,712,598
Ensembl chr20:40,618,128...40,712,592
JBrowse link
G Plcb1 phospholipase C beta 1 increases expression ISO Poly I-C results in increased expression of PLCB1 mRNA CTD PMID:24889602 NCBI chr 3:127,721,244...128,419,565
Ensembl chr 3:128,155,069...128,419,545
JBrowse link
G Plcxd2 phosphatidylinositol-specific phospholipase C, X domain containing 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of PLCXD2 mRNA CTD PMID:26923065 NCBI chr11:57,207,656...57,260,001
Ensembl chr11:57,207,656...57,260,568
JBrowse link
G Plekha8 pleckstrin homology domain containing A8 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of PLEKHA8 mRNA CTD PMID:26923065 NCBI chr 4:84,770,294...84,820,887
Ensembl chr 4:84,770,375...84,820,887
JBrowse link
G Plppr4 phospholipid phosphatase related 4 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of PLPPR4 mRNA CTD PMID:26923065 NCBI chr 2:220,298,239...220,341,863
Ensembl chr 2:220,298,245...220,341,866
JBrowse link
G Pmvk phosphomevalonate kinase multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of PMVK mRNA CTD PMID:26923065 NCBI chr 2:188,784,329...188,793,890
Ensembl chr 2:188,784,222...188,793,895
JBrowse link
G Pou5f1 POU class 5 homeobox 1 multiple interactions
increases expression
ISO Poly I-C promotes the reaction [MSI1 protein results in increased expression of POU5F1 protein]
Poly I-C results in increased expression of POU5F1 protein
CTD PMID:29486283 NCBI chr20:3,747,231...3,751,994
Ensembl chr20:3,747,221...3,751,994
JBrowse link
G Prf1 perforin 1 multiple interactions
increases expression
ISO Particulate Matter inhibits the reaction [Poly I-C results in increased expression of PRF1 protein]; Vehicle Emissions inhibits the reaction [Poly I-C results in increased expression of PRF1 protein]
Poly I-C results in increased expression of PRF1 mRNA; Poly I-C results in increased expression of PRF1 protein
CTD PMID:23618096 NCBI chr20:30,915,294...30,920,804
Ensembl chr20:30,915,213...30,921,382
JBrowse link
G Prkci protein kinase C, iota multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of PRKCI mRNA CTD PMID:26923065 NCBI chr 2:115,941,998...116,002,550
Ensembl chr 2:115,941,993...116,002,561
JBrowse link
G Prodh2 proline dehydrogenase 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of PRODH2 mRNA CTD PMID:26923065 NCBI chr 1:88,955,125...88,968,501
Ensembl chr 1:88,955,135...88,968,501
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO Poly I-C results in increased expression of PTGS2 protein
[Poly I-C results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine] which results in increased expression of PTGS2 mRNA; Poly I-C promotes the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of PTGS2 mRNA]; resveratrol inhibits the reaction [Poly I-C results in increased expression of PTGS2 protein]; Sodium Selenite inhibits the reaction [Poly I-C results in increased expression of PTGS2 protein]
CTD PMID:16116226 PMID:18279804 PMID:24889602 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Pvalb parvalbumin multiple interactions EXP [Poly I-C co-treated with Cannabidiol] results in increased expression of PVALB protein CTD PMID:31326506 NCBI chr 7:119,428,657...119,443,674
Ensembl chr 7:119,429,019...119,441,487
JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of RAC1 mRNA CTD PMID:26923065 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Rdm1 RAD52 motif containing 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of RDM1 mRNA CTD PMID:26923065 NCBI chr10:89,540,333...89,550,496
Ensembl chr10:89,539,556...89,550,500
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization
increases phosphorylation
multiple interactions
ISO Poly I-C affects the localization of RELA protein
Poly I-C results in increased phosphorylation of RELA protein
TP53 protein affects the reaction [Poly I-C affects the localization of RELA protein]
CTD PMID:18779317 PMID:24709138 PMID:27836898 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G RGD1305938 similar to expressed sequence AW549877 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of RGD1305938 mRNA CTD PMID:26923065 NCBI chr 2:53,813,129...53,827,329
Ensembl chr 2:53,813,131...53,827,175
JBrowse link
G RGD1307100 similar to RIKEN cDNA D630029K19 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of RGD1307100 mRNA CTD PMID:26923065 NCBI chr 2:123,555,742...123,766,675
Ensembl chr 2:123,555,673...123,766,676
JBrowse link
G RGD1309998 similar to Chain A, Solution Structure Of The Bola-Like Protein From Mus Musculus multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of RGD1309998 mRNA CTD PMID:26923065 NCBI chr 3:160,988,821...160,989,135 JBrowse link
G RGD1560015 similar to glycoprotein, synaptic 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of RGD1560015 mRNA CTD PMID:26923065 NCBI chr 1:47,587,022...47,588,088
Ensembl chr 1:47,587,021...47,588,122
JBrowse link
G RGD1561796 RGD1561796 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of RGD1561796 mRNA CTD PMID:26923065 NCBI chr10:11,878,043...11,880,822
Ensembl chr10:11,877,903...11,891,099
JBrowse link
G RGD1563963 similar to Phosphoglycerate mutase 1 (Phosphoglycerate mutase isozyme B) multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of RGD1563963 mRNA CTD PMID:26923065 NCBI chr10:53,299,185...53,330,755 JBrowse link
G Rgs4 regulator of G-protein signaling 4 increases expression ISO Poly I-C results in increased expression of RGS4 mRNA CTD PMID:24889602 NCBI chr13:88,054,817...88,061,108
Ensembl chr13:88,054,817...88,061,108
JBrowse link
G Rimbp2 RIMS binding protein 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of RIMBP2 mRNA CTD PMID:26923065 NCBI chr12:31,393,229...31,605,567
Ensembl chr12:31,530,699...31,620,760
JBrowse link
G rnf141 ring finger protein 141 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of RNF141 mRNA CTD PMID:26923065 NCBI chr 1:175,631,656...175,657,485
Ensembl chr 1:175,634,551...175,657,485
JBrowse link
G Rpl31 ribosomal protein L31 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of RPL31 mRNA CTD PMID:26923065 NCBI chr 9:46,086,959...46,090,444
Ensembl chr 9:46,086,984...46,090,997
JBrowse link
G Rps6kb2 ribosomal protein S6 kinase B2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of RPS6KB2 mRNA CTD PMID:26923065 NCBI chr 1:219,406,201...219,412,888
Ensembl chr 1:219,406,202...219,412,888
JBrowse link
G Rtn4rl1 reticulon 4 receptor-like 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of RTN4RL1 mRNA CTD PMID:26923065 NCBI chr10:62,035,866...62,109,075
Ensembl chr10:62,035,866...62,109,078
JBrowse link
G S100a3 S100 calcium binding protein A3 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of S100A3 mRNA CTD PMID:26923065 NCBI chr 2:189,955,619...189,996,029
Ensembl chr 2:189,955,836...189,996,029
JBrowse link
G Sema6d semaphorin 6D multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of SEMA6D mRNA CTD PMID:26923065 NCBI chr 3:116,899,906...116,958,059
Ensembl chr 3:116,899,878...116,958,050
JBrowse link
G Septin6 septin 6 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of SEPTIN6 mRNA CTD PMID:26923065 NCBI chr  X:123,524,954...123,601,214
Ensembl chr  X:123,524,950...123,662,350
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions
increases expression
ISO Chloroquine inhibits the reaction [Poly I-C results in increased expression of SERPINE1 mRNA]; Chloroquine inhibits the reaction [Poly I-C results in increased expression of SERPINE1 protein]; Hydroxychloroquine inhibits the reaction [Poly I-C results in increased expression of SERPINE1 mRNA]; Hydroxychloroquine inhibits the reaction [Poly I-C results in increased expression of SERPINE1 protein]; TLR3 mRNA promotes the reaction [Poly I-C results in increased expression of SERPINE1 mRNA]
Poly I-C results in increased expression of SERPINE1 mRNA; Poly I-C results in increased expression of SERPINE1 protein
CTD PMID:30341573 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Sesn2 sestrin 2 increases expression ISO Poly I-C results in increased expression of SESN2 mRNA CTD PMID:25637945 NCBI chr 5:150,684,891...150,703,846
Ensembl chr 5:150,684,133...150,704,117
JBrowse link
G Sgtb small glutamine rich tetratricopeptide repeat co-chaperone beta multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of SGTB mRNA CTD PMID:26923065 NCBI chr 2:34,185,938...34,222,428
Ensembl chr 2:34,186,091...34,219,802
JBrowse link
G Sh3rf1 SH3 domain containing ring finger 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of SH3RF1 mRNA CTD PMID:26923065 NCBI chr16:32,062,425...32,227,526
Ensembl chr16:32,062,336...32,227,491
JBrowse link
G Shroom2 shroom family member 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of SHROOM2 mRNA CTD PMID:26923065 NCBI chr  X:23,478,869...23,649,424
Ensembl chr  X:23,478,871...23,649,466
JBrowse link
G Sidt1 SID1 transmembrane family, member 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of SIDT1 mRNA CTD PMID:26923065 NCBI chr11:61,320,480...61,416,560
Ensembl chr11:61,321,459...61,417,842
JBrowse link
G Slc14a1 solute carrier family 14 member 1 (Kidd blood group) multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of SLC14A1 mRNA CTD PMID:26923065 NCBI chr18:74,461,064...74,504,475
Ensembl chr18:74,461,055...74,485,139
JBrowse link
G Slc17a7 solute carrier family 17 member 7 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of SLC17A7 mRNA CTD PMID:26923065 NCBI chr 1:101,161,265...101,172,292
Ensembl chr 1:101,161,252...101,173,174
JBrowse link
G Slc25a12 solute carrier family 25 member 12 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of SLC25A12 mRNA CTD PMID:26923065 NCBI chr 3:57,881,951...57,998,214
Ensembl chr 3:57,882,370...57,957,346
JBrowse link
G Slc25a14 solute carrier family 25 member 14 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of SLC25A14 mRNA CTD PMID:26923065 NCBI chr  X:135,470,855...135,509,223
Ensembl chr  X:135,470,915...135,509,221
JBrowse link
G Slc2a13 solute carrier family 2 member 13 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of SLC2A13 mRNA CTD PMID:26923065 NCBI chr 7:132,430,852...132,757,558
Ensembl chr 7:132,430,853...132,757,558
JBrowse link
G Slc3a1 solute carrier family 3 member 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of SLC3A1 mRNA CTD PMID:26923065 NCBI chr 6:8,284,937...8,318,649
Ensembl chr 6:8,284,878...8,318,674
JBrowse link
G Slc4a10 solute carrier family 4 member 10 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of SLC4A10 mRNA CTD PMID:26923065 NCBI chr 3:47,995,812...48,287,897
Ensembl chr 3:47,995,959...48,287,910
JBrowse link
G Smarcd1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of SMARCD1 mRNA CTD PMID:26923065 NCBI chr 7:141,355,623...141,366,725
Ensembl chr 7:141,355,994...141,366,732
JBrowse link
G Snrk SNF related kinase multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of SNRK mRNA CTD PMID:26923065 NCBI chr 8:130,749,806...130,805,225
Ensembl chr 8:130,749,838...130,803,597
JBrowse link
G Socs1 suppressor of cytokine signaling 1 increases expression
multiple interactions
ISO Poly I-C results in increased expression of SOCS1 mRNA
Progesterone promotes the reaction [Poly I-C results in increased expression of SOCS1 mRNA]
CTD PMID:22546503 NCBI chr10:4,956,795...4,958,472
Ensembl chr10:4,957,326...4,958,461
JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression ISO Poly I-C results in increased expression of SOCS3 mRNA CTD PMID:21195166 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
JBrowse link
G Sod2 superoxide dismutase 2 increases expression EXP Poly I-C results in increased expression of SOD2 mRNA CTD PMID:23939143 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sox2 SRY-box transcription factor 2 increases expression
multiple interactions
ISO Poly I-C results in increased expression of SOX2 protein
Poly I-C promotes the reaction [MSI1 protein results in increased expression of SOX2 protein]
CTD PMID:29486283 NCBI chr 2:121,165,137...121,167,545
Ensembl chr 2:121,165,137...121,167,545
JBrowse link
G Spag6l sperm associated antigen 6-like decreases expression EXP Poly I-C results in decreased expression of SPAG6 mRNA CTD PMID:26923065 NCBI chr11:88,424,493...88,517,910
Ensembl chr11:88,424,414...88,508,601
JBrowse link
G Srsf12 serine and arginine rich splicing factor 12 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of SRSF12 mRNA CTD PMID:26923065 NCBI chr 5:48,456,777...48,484,017
Ensembl chr 5:48,456,757...48,485,912
JBrowse link
G Srsf7 serine and arginine rich splicing factor 7 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of SRSF7 mRNA CTD PMID:26923065 NCBI chr 6:2,879,312...2,886,505
Ensembl chr 6:2,880,518...2,886,465
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions
increases expression
increases phosphorylation
ISO sodium arsenite inhibits the reaction [Poly I-C results in increased phosphorylation of STAT1 protein]
Poly I-C results in increased expression of STAT1 mRNA
IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of STAT1 mRNA]; Nicotine inhibits the reaction [Poly I-C results in increased expression of STAT1 mRNA]
CTD PMID:30726814 PMID:31154625 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stat2 signal transducer and activator of transcription 2 multiple interactions
increases expression
ISO IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of STAT2 mRNA] CTD PMID:31154625 NCBI chr 7:2,691,064...2,707,530
Ensembl chr 7:2,691,369...2,707,741
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO IL6 protein affects the reaction [Poly I-C results in increased phosphorylation of and results in increased activity of STAT3 protein]; Poly I-C results in increased phosphorylation of and results in increased activity of STAT3 protein CTD PMID:21195166 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Stxbp6 syntaxin binding protein 6 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of STXBP6 mRNA CTD PMID:26923065 NCBI chr 6:65,086,483...65,319,527
Ensembl chr 6:65,089,318...65,319,527
JBrowse link
G Svip small VCP interacting protein multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of SVIP mRNA CTD PMID:26923065 NCBI chr 1:107,368,117...107,373,807
Ensembl chr 1:107,368,117...107,373,807
JBrowse link
G Syt11 synaptotagmin 11 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of SYT11 mRNA CTD PMID:26923065 NCBI chr 2:188,112,301...188,138,180
Ensembl chr 2:188,112,286...188,138,177
JBrowse link
G Tbc1d9 TBC1 domain family member 9 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of TBC1D9 mRNA CTD PMID:26923065 NCBI chr19:24,328,381...24,429,908
Ensembl chr19:24,329,023...24,429,909
JBrowse link
G Tbk1 TANK-binding kinase 1 multiple interactions
increases phosphorylation
ISO APPL1 protein promotes the reaction [Poly I-C results in increased phosphorylation of TBK1 protein]; bafilomycin A1 promotes the reaction [Poly I-C results in increased phosphorylation of TBK1 protein] CTD PMID:25780039 NCBI chr 7:63,655,247...63,687,978
Ensembl chr 7:63,655,247...63,687,978
JBrowse link
G Terf2ip TERF2 interacting protein multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of TERF2IP mRNA CTD PMID:26923065 NCBI chr19:44,231,317...44,238,406
Ensembl chr19:44,231,251...44,238,404
JBrowse link
G Tfb1m transcription factor B1, mitochondrial multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of TFB1M mRNA CTD PMID:26923065 NCBI chr 1:44,433,116...44,474,674
Ensembl chr 1:44,433,116...44,474,674
JBrowse link
G Thy1 Thy-1 cell surface antigen multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of THY1 mRNA CTD PMID:26923065 NCBI chr 8:48,382,121...48,387,271
Ensembl chr 8:48,382,121...48,386,935
JBrowse link
G Ticam1 toll-like receptor adaptor molecule 1 increases expression ISO Poly I-C results in increased expression of TICAM1 mRNA CTD PMID:21418039 NCBI chr 9:10,780,185...10,790,280 JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO Poly I-C results in increased expression of TIMP1 mRNA CTD PMID:21195166 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tlr2 toll-like receptor 2 increases expression ISO Poly I-C results in increased expression of TLR2 mRNA CTD PMID:17669408 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tlr3 toll-like receptor 3 multiple interactions
increases activity
increases expression
ISO
EXP
[[Poly I-C binds to and results in increased activity of TLR3 protein] which co-treated with Nanotubes, Carbon] results in increased secretion of IL12B protein; [[Poly I-C binds to and results in increased activity of TLR3 protein] which co-treated with Nanotubes, Carbon] results in increased secretion of TNF protein; [Poly I-C binds to TLR3 protein] which affects the susceptibility to 1-aminopyrene; [Poly I-C binds to TLR3 protein] which affects the susceptibility to 1-nitropyrene; [Poly I-C binds to TLR3 protein] which affects the susceptibility to pyrene; [Vehicle Emissions analog co-treated with Poly I-C] results in increased expression of TLR3 mRNA; [Vehicle Emissions analog co-treated with Poly I-C] results in increased expression of TLR3 protein; Chloroquine inhibits the reaction [Poly I-C results in increased activity of TLR3 protein]; Poly I-C binds to and results in increased activity of TLR3 protein; Quinacrine inhibits the reaction [Poly I-C results in increased activity of TLR3 protein]; TLR3 mRNA promotes the reaction [Poly I-C results in increased expression of IL6 mRNA]; TLR3 mRNA promotes the reaction [Poly I-C results in increased expression of SERPINE1 mRNA]; TLR3 protein affects the reaction [Poly I-C results in increased expression of CXCL8 mRNA]; TLR3 protein affects the reaction [Poly I-C results in increased expression of IFNB1 mRNA]
MIR26A mRNA inhibits the reaction [Poly I-C results in increased activity of TLR3 protein]
Poly I-C results in increased expression of TLR3 mRNA
cinnamic aldehyde inhibits the reaction [Poly I-C results in increased expression of TLR3 mRNA]
CTD PMID:16399790 PMID:17669408 PMID:18306459 PMID:18779317 PMID:21398612 PMID:21418039 PMID:23266719 PMID:23458896 PMID:24423102 PMID:25780039 PMID:26682054 PMID:27385120 PMID:28003376 PMID:30341573 PMID:32244040 NCBI chr16:50,016,466...50,031,011
Ensembl chr16:50,016,857...50,031,214
JBrowse link
G Tlr7 toll-like receptor 7 increases expression ISO Poly I-C results in increased expression of TLR7 mRNA CTD PMID:17669408 NCBI chr  X:28,486,836...28,513,004
Ensembl chr  X:28,486,869...28,512,957
JBrowse link
G Tmem266 transmembrane protein 266 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of TMEM266 mRNA CTD PMID:26923065 NCBI chr 8:59,952,732...60,014,363
Ensembl chr 8:59,900,651...60,014,363
JBrowse link
G Tmem273 transmembrane protein 273 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of TMEM273 mRNA CTD PMID:26923065 NCBI chr16:9,023,387...9,054,664
Ensembl chr16:9,023,387...9,054,664
JBrowse link
G Tmprss2 transmembrane serine protease 2 decreases response to substance ISO TMPRSS2 gene mutant form results in decreased susceptibility to Poly I-C CTD PMID:30626688 NCBI chr11:38,063,914...38,103,406
Ensembl chr11:38,063,915...38,103,290
JBrowse link
G Tmx1 thioredoxin-related transmembrane protein 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of TMX1 mRNA CTD PMID:26923065 NCBI chr 6:92,864,123...92,875,141
Ensembl chr 6:92,864,123...92,874,204
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
increases secretion
ISO
EXP
2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane promotes the reaction [Poly I-C results in increased expression of TNF protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol promotes the reaction [Poly I-C results in increased expression of TNF protein]; [[Poly I-C binds to and results in increased activity of TLR3 protein] which co-treated with Nanotubes, Carbon] results in increased secretion of TNF protein; CEP-11004 inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; CpG ODN 2006 inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; Estradiol promotes the reaction [Poly I-C results in increased expression of TNF protein]; N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; pyrazolanthrone inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; RTKI cpd inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; SB 203580 inhibits the reaction [Poly I-C results in increased secretion of TNF protein]
Poly I-C results in increased expression of TNF mRNA; Poly I-C results in increased expression of TNF protein
cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester inhibits the reaction [Poly I-C results in increased expression of TNF mRNA]; MIR26A mRNA inhibits the reaction [Poly I-C results in increased expression of TNF mRNA]; MIR26A mRNA inhibits the reaction [Poly I-C results in increased expression of TNF protein]
APPL1 protein inhibits the reaction [Poly I-C results in increased expression of TNF protein]; Citrinin inhibits the reaction [Poly I-C results in increased expression of TNF mRNA]; Citrinin inhibits the reaction [Poly I-C results in increased expression of TNF protein]; Cycloheximide inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; Dimethyl Sulfoxide inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; Ethanol inhibits the reaction [Poly I-C results in increased expression of TNF mRNA]; Ethanol inhibits the reaction [Poly I-C results in increased expression of TNF protein]; Ethanol inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; Ethanol promotes the reaction [Hydroxamic Acids analog promotes the reaction [Dimethyl Sulfoxide inhibits the reaction [Poly I-C results in increased secretion of TNF protein]]]; Hydroxamic Acids analog inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; Hydroxamic Acids analog promotes the reaction [Dimethyl Sulfoxide inhibits the reaction [Poly I-C results in increased secretion of TNF protein]]; Luteolin inhibits the reaction [Poly I-C results in increased expression of TNF mRNA]; Poly I-C promotes the reaction [deoxynivalenol results in increased expression of TNF mRNA]; sodium arsenite inhibits the reaction [Poly I-C results in increased expression of TNF mRNA]
CTD PMID:16687389 PMID:17238832 PMID:17321468 PMID:17669408 PMID:17698565 PMID:17868967 PMID:18323514 PMID:19426678 PMID:19500611 PMID:20932985 PMID:22319556 PMID:22771370 PMID:23266719 PMID:23618096 PMID:23939143 PMID:24423102 PMID:25780039 PMID:27385120 PMID:28316773 PMID:28726298 PMID:30017638 PMID:30726814 PMID:30836164 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfsf10 TNF superfamily member 10 increases expression ISO Poly I-C results in increased expression of TNFSF10 mRNA; Poly I-C results in increased expression of TNFSF10 protein CTD PMID:16472598 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Tnks2 tankyrase 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of TNKS2 mRNA CTD PMID:26923065 NCBI chr 1:255,478,794...255,532,143
Ensembl chr 1:255,479,261...255,532,143
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO TP53 protein affects the reaction [Poly I-C affects the localization of RELA protein]; TP53 protein affects the reaction [Poly I-C results in increased expression of CXCL8 mRNA]; TP53 protein affects the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; TP53 protein affects the reaction [Poly I-C results in increased phosphorylation of IRF3 protein]; TP53 protein affects the reaction [Poly I-C results in increased phosphorylation of NFKBIA protein]; TP53 results in increased susceptibility to [Poly I-C co-treated with Fluorouracil] CTD PMID:18779317 PMID:20367642 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tpd52 tumor protein D52 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of TPD52 mRNA CTD PMID:26923065 NCBI chr 2:94,959,732...95,041,277
Ensembl chr 2:95,008,311...95,040,514
JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO TRAF6 mutant form inhibits the reaction [Vehicle Emissions analog promotes the reaction [Poly I-C results in increased expression of IL6 mRNA]] CTD PMID:16399790 NCBI chr 3:91,252,829...91,271,607
Ensembl chr 3:91,252,829...91,271,607
JBrowse link
G Trim2 tripartite motif-containing 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of TRIM2 mRNA CTD PMID:26923065 NCBI chr 2:183,145,096...183,223,819
Ensembl chr 2:183,145,089...183,213,228
JBrowse link
G Tslp thymic stromal lymphopoietin multiple interactions
increases expression
ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol promotes the reaction [Poly I-C results in increased expression of TSLP protein]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; [Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA; [Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; Estradiol promotes the reaction [Poly I-C results in increased expression of TSLP protein]; helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; IL4 protein promotes the reaction [Poly I-C results in increased expression of TSLP mRNA]; IL4 protein promotes the reaction [Poly I-C results in increased expression of TSLP protein]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]
Poly I-C results in increased expression of TSLP mRNA; Poly I-C results in increased expression of TSLP protein
CTD PMID:23688403 PMID:30017638 NCBI chr18:25,613,601...25,618,066
Ensembl chr18:25,613,831...25,617,361
JBrowse link
G Tspyl5 TSPY-like 5 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of TSPYL5 mRNA CTD PMID:26923065 NCBI chr 7:72,323,764...72,328,228
Ensembl chr 7:72,326,896...72,328,128
JBrowse link
G Ttc3 tetratricopeptide repeat domain 3 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of TTC3 mRNA CTD PMID:26923065 NCBI chr11:34,598,324...34,739,986
Ensembl chr11:34,598,492...34,738,791
JBrowse link
G Twist1 twist family bHLH transcription factor 1 decreases expression EXP Poly I-C results in decreased expression of TWIST1 mRNA CTD PMID:26923065 NCBI chr 6:53,401,241...53,403,235
Ensembl chr 6:53,401,109...53,403,214
JBrowse link
G Twsg1 twisted gastrulation BMP signaling modulator 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of TWSG1 mRNA CTD PMID:26923065 NCBI chr 9:113,699,151...113,732,601
Ensembl chr 9:113,699,170...113,732,622
JBrowse link
G Txn1 thioredoxin 1 multiple interactions
increases expression
EXP Diclofenac inhibits the reaction [Poly I-C results in increased expression of TXN1 mRNA] CTD PMID:23939143 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Ubl4a ubiquitin-like 4A multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of UBL4A mRNA CTD PMID:26923065 NCBI chr  X:156,340,919...156,343,771
Ensembl chr  X:156,340,925...156,343,777
JBrowse link
G Ubr1 ubiquitin protein ligase E3 component n-recognin 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of UBR1 mRNA CTD PMID:26923065 NCBI chr 3:112,800,557...112,910,038
Ensembl chr 3:112,800,557...112,876,773
JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 decreases expression EXP Poly I-C results in decreased expression of UGT2B1 mRNA CTD PMID:23939143 NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444
JBrowse link
G Usp32 ubiquitin specific peptidase 32 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of USP32 mRNA CTD PMID:26923065 NCBI chr10:72,300,173...72,474,574
Ensembl chr10:72,300,173...72,472,675
JBrowse link
G Vsnl1 visinin-like 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of VSNL1 mRNA CTD PMID:26923065 NCBI chr 6:37,001,360...37,121,969
Ensembl chr 6:37,001,356...37,122,023
JBrowse link
G Wac WW domain containing adaptor with coiled-coil multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of WAC mRNA CTD PMID:26923065 NCBI chr17:60,887,606...60,946,630
Ensembl chr17:60,888,017...60,946,426
JBrowse link
G Wdr47 WD repeat domain 47 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of WDR47 mRNA CTD PMID:26923065 NCBI chr 2:211,380,894...211,441,817
Ensembl chr 2:211,381,036...211,441,815
JBrowse link
G Zbtb6 zinc finger and BTB domain containing 6 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of ZBTB6 mRNA CTD PMID:26923065 NCBI chr 3:21,679,181...21,697,532
Ensembl chr 3:21,680,727...21,684,132
JBrowse link
G Zdhhc21 zinc finger DHHC-type palmitoyltransferase 21 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of ZDHHC21 mRNA CTD PMID:26923065 NCBI chr 5:100,924,621...100,983,412
Ensembl chr 5:100,924,622...100,977,902
JBrowse link
G Zfp354c zinc finger protein 354C multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of ZFP354C mRNA CTD PMID:26923065 NCBI chr10:36,311,343...36,322,356
Ensembl chr10:36,307,670...36,323,055
JBrowse link
G Zfp664 zinc finger protein 664 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of ZFOC1 mRNA CTD PMID:26923065 NCBI chr12:36,201,327...36,203,396 JBrowse link
G Zfp763 zinc finger protein 763 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of ZFP763 mRNA CTD PMID:26923065 NCBI chr 7:15,297,004...15,315,245
Ensembl chr 7:15,298,545...15,301,382
JBrowse link
sofosbuvir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Klrc1 killer cell lectin like receptor C1 decreases expression ISO sofosbuvir co-treated with ledipasvir decreased expression of NCR1 protein in natural killer cells RGD PMID:31218578 RGD:40400920 NCBI chr 4:163,453,435...163,463,718
Ensembl chr 4:163,458,528...163,463,718
JBrowse link
G Ncr1 natural cytotoxicity triggering receptor 1 affects expression ISO sofosbuvir co-treated with ledipasvir affects expression of NCR1 protein in natural killer cells RGD PMID:31218578 RGD:40400920 NCBI chr 1:73,178,917...73,226,504
Ensembl chr 1:73,179,013...73,226,777
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19771
    role 19716
      application 19406
        solvent 16547
          phosphoric acid 7954
            phosphoric acid derivative 7634
              organic phosphate 7633
                nucleoside phosphate 1710
                  nucleoside 5'-monophosphate 340
                    2'-deoxyribonucleoside monophosphate + 3
                    Ni(II)-pyridinium-3,5-bisthiocarboxylic acid mononucleotide 0
                    purine nucleoside monophosphate + 329
                    pyridinium-3,5-biscarboxylic acid mononucleotide + 0
                    pyridinium-3,5-bisthiocarboxylic acid mononucleotide 0
                    pyridinium-3-carboxy-5-thiocarboxylic acid mononucleotide 0
                    pyrimidine nucleoside monophosphate + 315
                    ribonucleoside monophosphate + 338
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      chalcogen 19387
                        oxygen atom 19350
                          oxygen molecular entity 19350
                            hydroxides 19076
                              oxoacid 18275
                                pnictogen oxoacid 10312
                                  phosphorus oxoacid 9234
                                    phosphoric acids 7954
                                      phosphoric acid 7954
                                        phosphoric acid derivative 7634
                                          phosphate 7634
                                            organic phosphate 7633
                                              nucleoside phosphate 1710
                                                nucleoside 5'-monophosphate 340
                                                  2'-deoxyribonucleoside monophosphate + 3
                                                  Ni(II)-pyridinium-3,5-bisthiocarboxylic acid mononucleotide 0
                                                  purine nucleoside monophosphate + 329
                                                  pyridinium-3,5-biscarboxylic acid mononucleotide + 0
                                                  pyridinium-3,5-bisthiocarboxylic acid mononucleotide 0
                                                  pyridinium-3-carboxy-5-thiocarboxylic acid mononucleotide 0
                                                  pyrimidine nucleoside monophosphate + 315
                                                  ribonucleoside monophosphate + 338
paths to the root