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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cerulenin
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Accession:CHEBI:171741 term browser browse the term
Definition:An epoxydodecadienamide isolated from several species, including Acremonium, Acrocylindrum and Helicoceras. It inhibits the biosynthesis of several lipids by interfering with enzyme function.
Synonyms:related_synonym: (2R,3S)-3-((4E,7E)-Nona-4,7-dienoyl)-oxirane-2-carboxylic acid amide;   (2R,3S)-3-((4E,7E)-nona-4,7-dienoyl)oxirane-2-carboxamide;   Formula=C12H17NO3;   InChI=1S/C12H17NO3/c1-2-3-4-5-6-7-8-9(14)10-11(16-10)12(13)15/h2-3,5-6,10-11H,4,7-8H2,1H3,(H2,13,15)/b3-2+,6-5+/t10-,11-/m1/s1;   InChIKey=GVEZIHKRYBHEFX-NQQPLRFYSA-N;   SMILES=[H][C@]1(O[C@]1([H])C(=O)CC\\C=C\\C\\C=C\\C)C(N)=O
 alt_id: CHEBI:29552
 xref: Beilstein:4807182;   CAS:17397-89-6;   DrugBank:DB01034;   Drug_Central:578;   KEGG:C12058;   KNApSAcK:C00018711
 xref_mesh: MESH:D002569


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cerulenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agrp agouti related neuropeptide increases expression ISO Cerulenin results in increased expression of AGRP mRNA CTD PMID:11289036 NCBI chr19:33,447,992...33,523,068
Ensembl chr19:33,447,992...33,449,584 		JBrowse link
G Asip agouti signaling protein affects response to substance ISO A protein affects the susceptibility to Cerulenin CTD PMID:11289036 NCBI chr 3:143,473,584...143,561,170
Ensembl chr 3:143,555,696...143,561,171 		JBrowse link
G Casp3 caspase 3 increases activity ISO Cerulenin results in increased activity of CASP3 protein CTD PMID:20805790 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases activity ISO Cerulenin results in increased activity of CASP9 protein CTD PMID:20805790 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression ISO Cerulenin results in decreased expression of CEBPA mRNA CTD PMID:15707987 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases phosphorylation ISO Cerulenin results in increased phosphorylation of EIF2A protein CTD PMID:17283163 NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO Cerulenin affects the reaction [ERN1 protein affects the splicing of XBP1 mRNA] CTD PMID:17283163 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Fasn fatty acid synthase multiple interactions
decreases activity
decreases expression		 ISO [Cerulenin results in decreased activity of FASN protein] which results in decreased abundance of Phosphorylcholine
Cerulenin results in decreased expression of FASN mRNA		 CTD PMID:12798352 PMID:15707987 PMID:18723500 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha multiple interactions ISO Cerulenin inhibits the reaction [Fructose results in decreased expression of HNF4A mRNA]; Cerulenin inhibits the reaction [Glucose results in decreased expression of HNF4A mRNA] CTD PMID:17992261 NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320 		JBrowse link
G Lep leptin affects response to substance ISO LEP protein affects the susceptibility to Cerulenin CTD PMID:11289036 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO Cerulenin results in decreased expression of PPARG mRNA CTD PMID:15707987 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Shbg sex hormone binding globulin multiple interactions ISO Cerulenin inhibits the reaction [Fructose results in decreased expression of SHBG protein]; Cerulenin inhibits the reaction [Glucose results in decreased expression of SHBG protein] CTD PMID:17992261 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057 		JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO Cerulenin affects the reaction [ERN1 protein affects the splicing of XBP1 mRNA] CTD PMID:17283163 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19818
    role 19790
      biological role 19788
        antimicrobial agent 17945
          cerulenin 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 19818
    subatomic particle 19816
      composite particle 19816
        hadron 19816
          baryon 19816
            nucleon 19816
              atomic nucleus 19816
                atom 19816
                  main group element atom 19761
                    p-block element atom 19761
                      carbon group element atom 19703
                        carbon atom 19698
                          organic molecular entity 19698
                            organic group 18905
                              organic divalent group 18887
                                organodiyl group 18887
                                  carbonyl group 18853
                                    carbonyl compound 18853
                                      carboxylic acid 18569
                                        carboacyl group 17687
                                          univalent carboacyl group 17687
                                            carbamoyl group 17531
                                              carboxamide 17531
                                                monocarboxylic acid amide 15585
                                                  cerulenin 13
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