Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cerulenin
go back to main search page
Accession:CHEBI:171741 term browser browse the term
Definition:An epoxydodecadienamide isolated from several species, including Acremonium, Acrocylindrum and Helicoceras. It inhibits the biosynthesis of several lipids by interfering with enzyme function.
Synonyms:related_synonym: (2R,3S)-3-((4E,7E)-Nona-4,7-dienoyl)-oxirane-2-carboxylic acid amide;   (2R,3S)-3-((4E,7E)-nona-4,7-dienoyl)oxirane-2-carboxamide;   Formula=C12H17NO3;   InChI=1S/C12H17NO3/c1-2-3-4-5-6-7-8-9(14)10-11(16-10)12(13)15/h2-3,5-6,10-11H,4,7-8H2,1H3,(H2,13,15)/b3-2+,6-5+/t10-,11-/m1/s1;   InChIKey=GVEZIHKRYBHEFX-NQQPLRFYSA-N;   SMILES=[H][C@]1(O[C@]1([H])C(=O)CC\\C=C\\C\\C=C\\C)C(N)=O
 alt_id: CHEBI:29552
 xref: Beilstein:4807182;   CAS:17397-89-6;   DrugBank:DB01034;   Drug_Central:578;   KEGG:C12058;   KNApSAcK:C00018711
 xref_mesh: MESH:D002569


show annotations for term's descendants           Sort by:
 
cerulenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agrp agouti related neuropeptide increases expression ISO Cerulenin results in increased expression of AGRP mRNA CTD PMID:11289036 NCBI chr19:33,447,992...33,523,068 JBrowse link
G Asip agouti signaling protein affects response to substance ISO A protein affects the susceptibility to Cerulenin CTD PMID:11289036 NCBI chr 3:143,473,584...143,561,170 JBrowse link
G Casp3 caspase 3 increases activity ISO Cerulenin results in increased activity of CASP3 protein CTD PMID:20805790 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Casp9 caspase 9 increases activity ISO Cerulenin results in increased activity of CASP9 protein CTD PMID:20805790 NCBI chr 5:154,108,872...154,126,628 JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression ISO Cerulenin results in decreased expression of CEBPA mRNA CTD PMID:15707987 NCBI chr 1:87,759,631...87,762,303 JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases phosphorylation ISO Cerulenin results in increased phosphorylation of EIF2A protein CTD PMID:17283163 NCBI chr 2:142,761,303...142,794,767 JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO Cerulenin affects the reaction [ERN1 protein affects the splicing of XBP1 mRNA] CTD PMID:17283163 NCBI chr10:91,326,889...91,421,201 JBrowse link
G Fasn fatty acid synthase multiple interactions
decreases activity
decreases expression
ISO [Cerulenin results in decreased activity of FASN protein] which results in decreased abundance of Phosphorylcholine
Cerulenin results in decreased expression of FASN mRNA
CTD PMID:12798352 PMID:15707987 PMID:18723500 NCBI chr10:106,072,093...106,090,259 JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha multiple interactions ISO Cerulenin inhibits the reaction [Fructose results in decreased expression of HNF4A mRNA]; Cerulenin inhibits the reaction [Glucose results in decreased expression of HNF4A mRNA] CTD PMID:17992261 NCBI chr 3:152,186,787...152,248,320 JBrowse link
G Lep leptin affects response to substance ISO LEP protein affects the susceptibility to Cerulenin CTD PMID:11289036 NCBI chr 4:57,661,127...57,675,262 JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO Cerulenin results in decreased expression of PPARG mRNA CTD PMID:15707987 NCBI chr 4:148,423,102...148,548,471 JBrowse link
G Shbg sex hormone binding globulin multiple interactions ISO Cerulenin inhibits the reaction [Fructose results in decreased expression of SHBG protein]; Cerulenin inhibits the reaction [Glucose results in decreased expression of SHBG protein] CTD PMID:17992261 NCBI chr10:54,332,939...54,350,409 JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO Cerulenin affects the reaction [ERN1 protein affects the splicing of XBP1 mRNA] CTD PMID:17283163 NCBI chr14:80,390,629...80,395,713 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19762
    role 19708
      biological role 19708
        antimicrobial agent 17369
          cerulenin 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 19762
    subatomic particle 19760
      composite particle 19760
        hadron 19760
          baryon 19760
            nucleon 19760
              atomic nucleus 19760
                atom 19760
                  main group element atom 19651
                    p-block element atom 19651
                      carbon group element atom 19570
                        carbon atom 19560
                          organic molecular entity 19560
                            organic group 18611
                              organic divalent group 18602
                                organodiyl group 18602
                                  carbonyl group 18519
                                    carbonyl compound 18519
                                      carboxylic acid 18195
                                        carboacyl group 17423
                                          univalent carboacyl group 17423
                                            carbamoyl group 17230
                                              carboxamide 17230
                                                monocarboxylic acid amide 14854
                                                  cerulenin 13
paths to the root