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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cerulenin
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Accession:CHEBI:171741 term browser browse the term
Definition:An epoxydodecadienamide isolated from several species, including Acremonium, Acrocylindrum and Helicoceras. It inhibits the biosynthesis of several lipids by interfering with enzyme function.
Synonyms:related_synonym: (2R,3S)-3-((4E,7E)-Nona-4,7-dienoyl)-oxirane-2-carboxylic acid amide;   (2R,3S)-3-((4E,7E)-nona-4,7-dienoyl)oxirane-2-carboxamide;   Formula=C12H17NO3;   InChI=1S/C12H17NO3/c1-2-3-4-5-6-7-8-9(14)10-11(16-10)12(13)15/h2-3,5-6,10-11H,4,7-8H2,1H3,(H2,13,15)/b3-2+,6-5+/t10-,11-/m1/s1;   InChIKey=GVEZIHKRYBHEFX-NQQPLRFYSA-N;   SMILES=[H][C@]1(O[C@]1([H])C(=O)CC\\C=C\\C\\C=C\\C)C(N)=O
 alt_id: CHEBI:29552
 xref: Beilstein:4807182;   CAS:17397-89-6;   DrugBank:DB01034;   Drug_Central:578;   KEGG:C12058;   KNApSAcK:C00018711
 xref_mesh: MESH:D002569



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cerulenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agrp agouti related neuropeptide increases expression ISO Cerulenin results in increased expression of AGRP mRNA CTD PMID:11289036 NCBI chr19:33,447,992...33,481,602
Ensembl chr19:33,447,992...33,449,584
JBrowse link
G Asip agouti signaling protein affects response to substance ISO A protein affects the susceptibility to Cerulenin CTD PMID:11289036 NCBI chr 3:143,473,584...143,561,170
Ensembl chr 3:143,555,696...143,561,171
JBrowse link
G Casp3 caspase 3 increases activity ISO Cerulenin results in increased activity of CASP3 protein CTD PMID:20805790 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 increases activity ISO Cerulenin results in increased activity of CASP9 protein CTD PMID:20805790 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression ISO Cerulenin results in decreased expression of CEBPA mRNA CTD PMID:15707987 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases phosphorylation ISO Cerulenin results in increased phosphorylation of EIF2A protein CTD PMID:17283163 NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO Cerulenin affects the reaction [ERN1 protein affects the splicing of XBP1 mRNA] CTD PMID:17283163 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Fasn fatty acid synthase multiple interactions
decreases activity
decreases expression
ISO [Cerulenin results in decreased activity of FASN protein] which results in decreased abundance of Phosphorylcholine
Cerulenin results in decreased expression of FASN mRNA
CTD PMID:12798352 PMID:15707987 PMID:18723500 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha multiple interactions ISO Cerulenin inhibits the reaction [Fructose results in decreased expression of HNF4A mRNA]; Cerulenin inhibits the reaction [Glucose results in decreased expression of HNF4A mRNA] CTD PMID:17992261 NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320
JBrowse link
G Lep leptin affects response to substance ISO LEP protein affects the susceptibility to Cerulenin CTD PMID:11289036 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Piezo1 piezo-type mechanosensitive ion channel component 1 affects expression ISO Cerulenin affects the expression of PIEZO1 protein CTD PMID:37117602 NCBI chr19:50,544,580...50,606,812
Ensembl chr19:50,544,582...50,606,501
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO Cerulenin results in decreased expression of PPARG mRNA CTD PMID:15707987 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Shbg sex hormone binding globulin multiple interactions ISO Cerulenin inhibits the reaction [Fructose results in decreased expression of SHBG protein]; Cerulenin inhibits the reaction [Glucose results in decreased expression of SHBG protein] CTD PMID:17992261 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO Cerulenin affects the reaction [ERN1 protein affects the splicing of XBP1 mRNA] CTD PMID:17283163 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
JBrowse link

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  CHEBI ontology 19863
    role 19835
      biological role 19833
        antimicrobial agent 18223
          cerulenin 14
Path 2
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  CHEBI ontology 19863
    subatomic particle 19861
      composite particle 19861
        hadron 19861
          baryon 19861
            nucleon 19861
              atomic nucleus 19861
                atom 19861
                  main group element atom 19807
                    p-block element atom 19807
                      carbon group element atom 19748
                        carbon atom 19744
                          organic molecular entity 19744
                            heteroorganic entity 19498
                              organochalcogen compound 19259
                                organooxygen compound 19175
                                  carbon oxoacid 18642
                                    carboxylic acid 18639
                                      carboacyl group 17708
                                        univalent carboacyl group 17708
                                          carbamoyl group 17559
                                            carboxamide 17559
                                              monocarboxylic acid amide 15689
                                                cerulenin 14
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