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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2,8-bis-Trifluoromethyl-4-quinoline carboxylic acid
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Accession:CHEBI:171694 term browser browse the term
Synonyms:exact_synonym: 2,8-bis(triluoromethyl)quinoline-4-carboxylic acid
 related_synonym: Formula=C12H5F6NO2;   InChI=1S/C12H5F6NO2/c13-11(14,15)7-3-1-2-5-6(10(20)21)4-8(12(16,17)18)19-9(5)7/h1-4H,(H,20,21);   InChIKey=QJTJIQBSZLFWFS-UHFFFAOYSA-N;   SMILES=FC(F)(F)C=1C=2N=C(C=C(C2C=CC1)C(O)=O)C(F)(F)F
 xref: CAS:35853-50-0;   Chemspider:148424;   HMDB:HMDB0060726
 xref_mesh: MESH:C057006


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2,8-bis-Trifluoromethyl-4-quinoline carboxylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO Ro 21-5104 results in increased expression of ABCB1 mRNA CTD PMID:25313206 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression
multiple interactions		 ISO Ro 21-5104 results in increased expression of CYP2B6 mRNA; Ro 21-5104 results in increased expression of CYP2B6 protein
NR1I2 mRNA promotes the reaction [Ro 21-5104 results in increased expression of CYP2B6 mRNA]		 CTD PMID:25313206 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases expression ISO Ro 21-5104 results in increased expression of CYP2C8 mRNA CTD PMID:25313206
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases expression		 ISO NR1I2 mRNA promotes the reaction [Ro 21-5104 results in increased expression of CYP3A4 mRNA]
Ro 21-5104 results in increased expression of CYP3A4 mRNA; Ro 21-5104 results in increased expression of CYP3A4 protein		 CTD PMID:25313206 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression ISO Ro 21-5104 results in increased expression of EPHX1 mRNA CTD PMID:25313206 NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235 		JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO Ro 21-5104 promotes the reaction [NR1I2 protein binds to NCOA1 protein] CTD PMID:25313206 NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664 		JBrowse link
G Ncor2 nuclear receptor co-repressor 2 multiple interactions ISO Ro 21-5104 inhibits the reaction [NR1I2 protein binds to NCOR2 protein] CTD PMID:25313206 NCBI chr12:31,466,418...31,628,319
Ensembl chr12:31,466,412...31,628,319 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO NR1I2 mRNA promotes the reaction [Ro 21-5104 results in increased expression of CYP2B6 mRNA]; NR1I2 mRNA promotes the reaction [Ro 21-5104 results in increased expression of CYP3A4 mRNA]; Ro 21-5104 binds to and results in increased activity of NR1I2 protein; Ro 21-5104 inhibits the reaction [NR1I2 protein binds to NCOR2 protein]; Ro 21-5104 promotes the reaction [NR1I2 protein binds to NCOA1 protein] CTD PMID:25313206 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases expression ISO Ro 21-5104 results in increased expression of UGT1A3 mRNA CTD PMID:25313206 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    chemical entity 19909
      molecular entity 19880
        polyatomic entity 19862
          molecule 19752
            organic molecule 19737
              organic cyclic compound 19526
                organic aromatic compound 19390
                  quinolines 2665
                    2,8-bis-Trifluoromethyl-4-quinoline carboxylic acid 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      carbon group element atom 19766
                        carbon atom 19785
                          organic molecular entity 19785
                            organic molecule 19737
                              organic cyclic compound 19526
                                organic heterocyclic compound 18870
                                  organonitrogen heterocyclic compound 18174
                                    quinolines 2665
                                      2,8-bis-Trifluoromethyl-4-quinoline carboxylic acid 9
paths to the root