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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:xylitol
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Accession:CHEBI:17151 term browser browse the term
Definition:A pentitol (five-carbon sugar alcohol) having meso-configuration, being derived from xylose by reduction of the carbonyl group.
Synonyms:exact_synonym: (2R,3r,4S)-pentane-1,2,3,4,5-pentol
 related_synonym: (2R,3R,4S)-Pentane-1,2,3,4,5-pentaol;   D-XYLITOL;   Formula=C5H12O5;   InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+;   InChIKey=HEBKCHPVOIAQTA-SCDXWVJYSA-N;   L-xylitol;   Meso-xylitol;   SMILES=OC[C@H](O)[C@@H](O)[C@H](O)CO;   Xylit;   xylite
 alt_id: CHEBI:10078;   CHEBI:15328;   CHEBI:253147;   CHEBI:27339;   CHEBI:46522;   CHEBI:60939
 xref: Beilstein:1720523;   CAS:87-99-0;   DrugBank:DB01904;   Drug_Central:4604;   Gmelin:82893;   HMDB:HMDB0002917;   KEGG:C00379;   KEGG:D00061
 xref_mesh: MESH:D014993
 xref: MetaCyc:XYLITOL;   PDBeChem:XYL;   PMID:11154411;   PMID:11163479;   PMID:12061879;   PMID:15377394;   PMID:16708791;   PMID:16901854;   PMID:17216457;   PMID:17216458;   PMID:17336832;   PMID:17979222;   PMID:18316079;   PMID:20030329;   PMID:22735334;   PMID:22791282;   PMID:23247825;   PMID:23287496;   PMID:23338824;   PMID:23589387;   PMID:23597921;   PMID:23615861;   PMID:23796483;   PMID:23916161;   PMID:23957303;   PMID:24012734;   PMID:24643482;   PMID:25108762;   Reaxys:1720523;   Wikipedia:Xylitol


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xylitol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase increases expression EXP Xylitol results in increased expression of ABL2 mRNA CTD PMID:32275922 NCBI chr 1:179,099,330...179,229,677
Ensembl chr 1:179,099,330...179,229,684 		JBrowse link
G AKR7L aldo-keto reductase family 7 like (gene/pseudogene) increases expression EXP Xylitol results in increased expression of AKR7L mRNA CTD PMID:32275922 NCBI chr 1:19,265,982...19,274,122
Ensembl chr 1:19,265,982...19,274,194 		JBrowse link
G ARHGEF2 Rho/Rac guanine nucleotide exchange factor 2 increases expression EXP Xylitol results in increased expression of ARHGEF2 mRNA CTD PMID:32275922 NCBI chr 1:155,946,854...155,979,617
Ensembl chr 1:155,946,851...156,007,070 		JBrowse link
G ASH1L ASH1 like histone lysine methyltransferase increases expression EXP Xylitol results in increased expression of ASH1L mRNA CTD PMID:32275922 NCBI chr 1:155,335,268...155,563,202
Ensembl chr 1:155,335,268...155,563,162 		JBrowse link
G ATF4 activating transcription factor 4 increases expression EXP Xylitol results in increased expression of ATF4 protein CTD PMID:32275922 NCBI chr22:39,520,559...39,522,686
Ensembl chr22:39,519,695...39,522,683 		JBrowse link
G BCAP29 B cell receptor associated protein 29 decreases expression EXP Xylitol results in decreased expression of BCAP29 mRNA CTD PMID:32275922 NCBI chr 7:107,580,007...107,623,317
Ensembl chr 7:107,580,246...107,629,170 		JBrowse link
G BIRC6 baculoviral IAP repeat containing 6 increases expression EXP Xylitol results in increased expression of BIRC6 mRNA CTD PMID:32275922 NCBI chr 2:32,357,023...32,618,878
Ensembl chr 2:32,357,023...32,619,571 		JBrowse link
G CASP3 caspase 3 increases expression EXP Xylitol results in increased expression of CASP3 protein modified form CTD PMID:32275922 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CEP250 centrosomal protein 250 increases expression EXP Xylitol results in increased expression of CEP250 mRNA CTD PMID:32275922 NCBI chr20:35,455,165...35,519,280
Ensembl chr20:35,455,164...35,519,280 		JBrowse link
G CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 increases expression
multiple interactions		 EXP Xylitol results in increased expression of CHAC1 mRNA; Xylitol results in increased expression of CHAC1 protein
ursodoxicoltaurine inhibits the reaction [Xylitol results in increased expression of CHAC1 protein]		 CTD PMID:32275922 NCBI chr15:40,953,471...40,956,512
Ensembl chr15:40,952,962...40,956,512 		JBrowse link
G CIT citron rho-interacting serine/threonine kinase increases expression EXP Xylitol results in increased expression of CIT mRNA CTD PMID:32275922 NCBI chr12:119,685,791...119,877,320
Ensembl chr12:119,685,791...119,877,320 		JBrowse link
G CYCS cytochrome c, somatic decreases expression EXP Xylitol results in decreased expression of CYCS mRNA CTD PMID:32275922 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260 		JBrowse link
G DCT dopachrome tautomerase decreases expression EXP Xylitol results in decreased expression of DCT mRNA CTD PMID:32275922 NCBI chr13:94,436,811...94,549,406
Ensembl chr13:94,436,811...94,479,682 		JBrowse link
G DCXR dicarbonyl and L-xylulose reductase multiple interactions
increases chemical synthesis		 EXP [DCXR protein results in increased metabolism of Xylulose] which results in increased chemical synthesis of Xylitol
DCXR protein results in increased chemical synthesis of Xylitol		 CTD PMID:28595002 NCBI chr17:82,035,858...82,037,697
Ensembl chr17:82,035,136...82,037,709 		JBrowse link
G FLNA filamin A increases expression EXP Xylitol results in increased expression of FLNA mRNA CTD PMID:32275922 NCBI chr  X:154,348,531...154,374,634
Ensembl chr  X:154,348,524...154,374,634 		JBrowse link
G FMN1 formin 1 increases expression EXP Xylitol results in increased expression of FMN1 mRNA CTD PMID:32275922 NCBI chr15:32,765,544...33,194,714
Ensembl chr15:32,765,544...33,194,714 		JBrowse link
G FOXK1 forkhead box K1 increases expression EXP Xylitol results in increased expression of FOXK1 mRNA CTD PMID:32275922 NCBI chr 7:4,682,295...4,771,442
Ensembl chr 7:4,682,295...4,771,442 		JBrowse link
G G6PC1 glucose-6-phosphatase catalytic subunit 1 multiple interactions ISO [Aminooxyacetic Acid co-treated with Xylitol] results in increased expression of G6PC1 mRNA CTD PMID:31974165 NCBI chr17:42,900,799...42,914,438
Ensembl chr17:42,900,797...42,914,438 		JBrowse link
G GPD2 glycerol-3-phosphate dehydrogenase 2 multiple interactions ISO [Aminooxyacetic Acid co-treated with Xylitol] results in increased expression of GPD2 mRNA CTD PMID:31974165 NCBI chr 2:156,400,281...156,586,403
Ensembl chr 2:156,435,290...156,613,735 		JBrowse link
G GPM6B glycoprotein M6B decreases expression EXP Xylitol results in decreased expression of GPM6B mRNA CTD PMID:32275922 NCBI chr  X:13,770,939...13,938,638
Ensembl chr  X:13,770,939...13,938,638 		JBrowse link
G HIPK2 homeodomain interacting protein kinase 2 increases expression EXP Xylitol results in increased expression of HIPK2 mRNA CTD PMID:32275922 NCBI chr 7:139,561,570...139,777,998
Ensembl chr 7:139,561,570...139,777,998 		JBrowse link
G HMCN1 hemicentin 1 increases expression EXP Xylitol results in increased expression of HMCN1 mRNA CTD PMID:32275922 NCBI chr 1:185,734,391...186,190,949
Ensembl chr 1:185,734,391...186,190,949 		JBrowse link
G HNRNPUL2 heterogeneous nuclear ribonucleoprotein U like 2 increases expression EXP Xylitol results in increased expression of HNRNPUL2 mRNA CTD PMID:32275922 NCBI chr11:62,712,630...62,727,457
Ensembl chr11:62,712,630...62,727,457 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression		 EXP ursodoxicoltaurine inhibits the reaction [Xylitol results in increased expression of HSPA5 protein] CTD PMID:32275922 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382 		JBrowse link
G INHBA inhibin subunit beta A increases expression EXP Xylitol results in increased expression of INHBA mRNA CTD PMID:32275922 NCBI chr 7:41,685,114...41,705,406
Ensembl chr 7:41,667,168...41,705,834 		JBrowse link
G INTS4P1 integrator complex subunit 4 pseudogene 1 increases expression EXP Xylitol results in increased expression of INTS4P1 mRNA CTD PMID:32275922 NCBI chr 7:65,141,030...65,234,222
Ensembl chr 7:65,141,241...65,212,794
Ensembl chr 7:65,141,241...65,212,794 		JBrowse link
G IQGAP3 IQ motif containing GTPase activating protein 3 increases expression EXP Xylitol results in increased expression of IQGAP3 mRNA CTD PMID:32275922 NCBI chr 1:156,525,405...156,572,565
Ensembl chr 1:156,525,405...156,572,604 		JBrowse link
G KMT2D lysine methyltransferase 2D increases expression EXP Xylitol results in increased expression of KMT2D mRNA CTD PMID:32275922 NCBI chr12:49,018,978...49,060,794
Ensembl chr12:49,018,975...49,060,794 		JBrowse link
G LSM5 LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated decreases expression EXP Xylitol results in decreased expression of LSM5 mRNA CTD PMID:32275922 NCBI chr 7:32,485,338...32,495,283
Ensembl chr 7:32,485,338...32,495,283 		JBrowse link
G MACF1 microtubule actin crosslinking factor 1 increases expression EXP Xylitol results in increased expression of MACF1 mRNA CTD PMID:32275922 NCBI chr 1:39,084,167...39,487,138
Ensembl chr 1:39,081,316...39,487,177 		JBrowse link
G MAFK MAF bZIP transcription factor K increases expression EXP Xylitol results in increased expression of MAFK mRNA CTD PMID:32275922 NCBI chr 7:1,530,702...1,543,043
Ensembl chr 7:1,530,702...1,543,043 		JBrowse link
G MAP1B microtubule associated protein 1B increases expression EXP Xylitol results in increased expression of MAP1B mRNA CTD PMID:32275922 NCBI chr 5:72,107,475...72,209,565
Ensembl chr 5:72,107,234...72,209,565 		JBrowse link
G MLXIPL MLX interacting protein like multiple interactions
increases expression		 ISO [Aminooxyacetic Acid co-treated with Xylitol] results in increased expression of MLXIPL mRNA alternative form
Xylitol results in increased expression of MLXIPL mRNA alternative form		 CTD PMID:31974165 NCBI chr 7:73,593,202...73,647,907
Ensembl chr 7:73,593,194...73,624,543 		JBrowse link
G MRPL34 mitochondrial ribosomal protein L34 decreases expression EXP Xylitol results in decreased expression of MRPL34 mRNA CTD PMID:32275922 NCBI chr19:17,292,573...17,306,843
Ensembl chr19:17,292,609...17,306,843 		JBrowse link
G MSMO1 methylsterol monooxygenase 1 decreases expression EXP Xylitol results in decreased expression of MSMO1 mRNA CTD PMID:32275922 NCBI chr 4:165,327,669...165,343,164
Ensembl chr 4:165,327,667...165,343,164 		JBrowse link
G MSTO2P misato family member 2, pseudogene increases expression EXP Xylitol results in increased expression of MSTO2P mRNA CTD PMID:32275922 NCBI chr 1:155,745,768...155,750,688
Ensembl chr 1:155,745,829...155,750,137 		JBrowse link
G NKD1 NKD inhibitor of WNT signaling pathway 1 increases expression EXP Xylitol results in increased expression of NKD1 mRNA CTD PMID:32275922 NCBI chr16:50,548,396...50,649,249
Ensembl chr16:50,548,396...50,649,249 		JBrowse link
G NPIPA2 nuclear pore complex interacting protein family member A2 increases expression EXP Xylitol results in increased expression of NPIPA2 mRNA CTD PMID:32275922 NCBI chr16:14,742,533...14,765,462
Ensembl chr16:14,742,533...14,765,462
Ensembl chr16:14,742,533...14,765,462 		JBrowse link
G NSD2 nuclear receptor binding SET domain protein 2 increases expression EXP Xylitol results in increased expression of WHSC1 mRNA CTD PMID:32275922 NCBI chr 4:1,871,393...1,982,192
Ensembl chr 4:1,871,393...1,982,207 		JBrowse link
G OAT ornithine aminotransferase multiple interactions ISO Xylitol inhibits the reaction [Cyclic AMP results in increased activity of OAT protein] CTD PMID:2827574 NCBI chr10:124,397,303...124,418,923
Ensembl chr10:124,397,303...124,418,976 		JBrowse link
G PIR pirin decreases expression EXP Xylitol results in decreased expression of PIR mRNA CTD PMID:32275922 NCBI chr  X:15,384,799...15,493,333
Ensembl chr  X:15,384,799...15,493,564 		JBrowse link
G PKD1 polycystin 1, transient receptor potential channel interacting increases expression EXP Xylitol results in increased expression of PKD1 mRNA CTD PMID:32275922 NCBI chr16:2,088,708...2,135,898
Ensembl chr16:2,088,708...2,135,898 		JBrowse link
G POLE DNA polymerase epsilon, catalytic subunit increases expression EXP Xylitol results in increased expression of POLE mRNA CTD PMID:32275922 NCBI chr12:132,623,762...132,687,342
Ensembl chr12:132,623,753...132,687,376 		JBrowse link
G PRRC2B proline rich coiled-coil 2B increases expression EXP Xylitol results in increased expression of PRRC2B mRNA CTD PMID:32275922 NCBI chr 9:131,373,651...131,500,193
Ensembl chr 9:131,373,636...131,500,197 		JBrowse link
G RAB5IF RAB5 interacting factor decreases expression EXP Xylitol results in decreased expression of RAB5IF mRNA CTD PMID:32275922 NCBI chr20:36,605,779...36,612,557
Ensembl chr20:36,605,779...36,612,557 		JBrowse link
G RERE arginine-glutamic acid dipeptide repeats increases expression EXP Xylitol results in increased expression of RERE mRNA CTD PMID:32275922 NCBI chr 1:8,352,404...8,817,640
Ensembl chr 1:8,352,397...8,848,921 		JBrowse link
G RPP21 ribonuclease P/MRP subunit p21 decreases expression EXP Xylitol results in decreased expression of RPP21 mRNA CTD PMID:32275922 NCBI chr 6:30,345,156...30,346,857
Ensembl chr 6:30,345,131...30,346,884 		JBrowse link
G SLC45A2 solute carrier family 45 member 2 decreases expression EXP Xylitol results in decreased expression of SLC45A2 mRNA CTD PMID:32275922 NCBI chr 5:33,944,623...33,984,693
Ensembl chr 5:33,944,623...33,984,693 		JBrowse link
G SLCO5A1 solute carrier organic anion transporter family member 5A1 increases expression EXP Xylitol results in increased expression of SLCO5A1 mRNA CTD PMID:32275922 NCBI chr 8:69,667,046...69,834,978
Ensembl chr 8:69,667,046...69,834,978 		JBrowse link
G SNORA48 small nucleolar RNA, H/ACA box 48 decreases expression EXP Xylitol results in decreased expression of SNORA48 mRNA CTD PMID:32275922 NCBI chr17:7,574,713...7,574,847
Ensembl chr17:7,574,713...7,574,847 		JBrowse link
G SOCS4 suppressor of cytokine signaling 4 decreases expression EXP Xylitol results in decreased expression of SOCS4 mRNA CTD PMID:32275922 NCBI chr14:55,027,236...55,049,489
Ensembl chr14:55,027,230...55,049,489 		JBrowse link
G SPCS3 signal peptidase complex subunit 3 decreases expression EXP Xylitol results in decreased expression of SPCS3 mRNA CTD PMID:32275922 NCBI chr 4:176,319,966...176,332,245
Ensembl chr 4:176,319,966...176,332,245 		JBrowse link
G SRRM2 serine/arginine repetitive matrix 2 increases expression EXP Xylitol results in increased expression of SRRM2 mRNA CTD PMID:32275922 NCBI chr16:2,752,638...2,771,412
Ensembl chr16:2,752,626...2,772,538 		JBrowse link
G TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 increases expression EXP Xylitol results in increased expression of TANC2 mRNA CTD PMID:32275922 NCBI chr17:62,966,235...63,427,703
Ensembl chr17:62,966,235...63,427,703 		JBrowse link
G TMED5 transmembrane p24 trafficking protein 5 decreases expression EXP Xylitol results in decreased expression of TMED5 mRNA CTD PMID:32275922 NCBI chr 1:93,149,742...93,180,413
Ensembl chr 1:93,149,742...93,180,516 		JBrowse link
G TMEM59 transmembrane protein 59 decreases expression EXP Xylitol results in decreased expression of TMEM59 mRNA CTD PMID:32275922 NCBI chr 1:54,026,681...54,053,573
Ensembl chr 1:54,026,681...54,053,504 		JBrowse link
G TMEM64 transmembrane protein 64 decreases expression EXP Xylitol results in decreased expression of TMEM64 mRNA CTD PMID:32275922 NCBI chr 8:90,621,995...90,646,083
Ensembl chr 8:90,621,995...90,791,632 		JBrowse link
G TNKS tankyrase increases expression EXP Xylitol results in increased expression of TNKS mRNA CTD PMID:32275922 NCBI chr 8:9,555,912...9,782,346
Ensembl chr 8:9,555,912...9,782,346 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    role 25961
      biological role 25929
        hapten 3077
          xylitol 58
            xylitol 5-phosphate 0
            xylitol 5-phosphate(2-) 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    p-block element atom 25834
                      carbon group element atom 25434
                        carbon atom 25403
                          organic molecular entity 25392
                            heteroorganic entity 24766
                              organochalcogen compound 24378
                                organooxygen compound 24054
                                  carbohydrates and carbohydrate derivatives 16772
                                    carbohydrate 16785
                                      alditol 3421
                                        pentitol 59
                                          xylitol 58
                                            xylitol 5-phosphate 0
                                            xylitol 5-phosphate(2-) 0
paths to the root