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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:putrescine
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Accession:CHEBI:17148 term browser browse the term
Definition:A four-carbon alkane-alpha,omega-diamine. It is obtained by the breakdown of amino acids and is responsible for the foul odour of putrefying flesh.
Synonyms:related_synonym: 1,4-Butanediamine;   1,4-DIAMINOBUTANE;   1,4-butylenediamine;   1,4-tetramethylenediamine;   Butane-1,4-diamine;   Formula=C4H12N2;   H2N(CH2)4NH2;   InChI=1S/C4H12N2/c5-3-1-2-4-6/h1-6H2;   InChIKey=KIDHWZJUCRJVML-UHFFFAOYSA-N;   Putrescin;   Putreszin;   SMILES=NCCCCN;   Tetramethylendiamin;   Tetramethylenediamine;   butylenediamine;   putrescina
 alt_id: CHEBI:14972;   CHEBI:26405;   CHEBI:45092;   CHEBI:8650
 xref: BPDB:1393;   Beilstein:605282;   CAS:110-60-1;   DrugBank:DB01917;   ECMDB:ECMDB01414;   Gmelin:1715;   HMDB:HMDB0001414;   KEGG:C00134;   KNApSAcK:C00001428
 xref_mesh: MESH:D011700
 xref: MetaCyc:PUTRESCINE;   PDBeChem:PUT;   PMID:12053479;   PMID:15453685;   PMID:16346523;   PMID:18721677;   PMID:22735334;   PMID:24331418;   PMID:24820075;   PMID:24864091;   Reaxys:605282;   Wikipedia:Putrescine;   YMDB:YMDB00132
 cyclic_relationship: is_conjugate_base_of CHEBI:326268


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putrescine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 multiple interactions ISO Putrescine binds to and results in increased activity of ADRB1 protein CTD PMID:20885010 NCBI chr 1:255,772,217...255,773,617
Ensembl chr 1:255,771,597...255,807,259 		JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions ISO Putrescine binds to and results in increased activity of ADRB2 protein CTD PMID:20885010 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Amd1 adenosylmethionine decarboxylase 1 multiple interactions ISO [Sulindac co-treated with Putrescine] results in decreased activity of AMD1 protein CTD PMID:17474863 NCBI chr20:43,695,783...43,711,476
Ensembl chr20:43,697,237...43,711,476 		JBrowse link
G Aoc1 amine oxidase, copper containing 1 increases degradation
increases metabolic processing
multiple interactions		 ISO
EXP		 AOC1 protein results in increased degradation of Putrescine
AOC1 protein results in increased metabolism of Putrescine
Amiloride inhibits the reaction [AOC1 protein results in increased degradation of Putrescine]; ethylisopropylamiloride inhibits the reaction [AOC1 protein results in increased degradation of Putrescine]; phenylamil inhibits the reaction [AOC1 protein results in increased degradation of Putrescine]; pimagedine inhibits the reaction [AOC1 protein results in increased degradation of Putrescine]		 CTD PMID:1644166 PMID:8144586 PMID:12072962 NCBI chr 4:77,812,260...77,831,846
Ensembl chr 4:77,812,260...77,831,840 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression EXP Putrescine results in decreased expression of BCL2 protein CTD PMID:17606387 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 increases expression EXP Putrescine results in increased expression of CASP3 protein CTD PMID:17606387 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases expression EXP Putrescine results in increased expression of CASP9 protein CTD PMID:17606387 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Eif3b eukaryotic translation initiation factor 3, subunit B multiple interactions EXP [ODC1 protein results in increased abundance of Putrescine] which results in decreased expression of EIF3B protein; Pentanoic Acids inhibits the reaction [[ODC1 protein results in increased abundance of Putrescine] which results in decreased expression of EIF3B protein]; Putrescine inhibits the reaction [Pentanoic Acids results in increased expression of EIF3B protein] CTD PMID:22555848 NCBI chr12:14,196,403...14,220,865
Ensembl chr12:14,196,403...14,220,886 		JBrowse link
G Elavl1 ELAV like RNA binding protein 1 multiple interactions EXP Putrescine inhibits the reaction [Ornithine Decarboxylase Inhibitors affects the localization of ELAVL1 protein]; Putrescine inhibits the reaction [Ornithine Decarboxylase Inhibitors promotes the reaction [ELAVL1 protein binds to JUND 3' UTR]] CTD PMID:20805360 NCBI chr12:2,640,936...2,684,787
Ensembl chr12:2,645,061...2,684,784 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Putrescine results in increased expression of FOS mRNA CTD PMID:8048943 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Hnrnpd heterogeneous nuclear ribonucleoprotein D multiple interactions EXP Putrescine inhibits the reaction [Ornithine Decarboxylase Inhibitors inhibits the reaction [HNRNPD protein binds to JUND 3' UTR]] CTD PMID:20805360 NCBI chr14:9,615,375...9,638,975
Ensembl chr14:9,615,479...9,633,786 		JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Putrescine inhibits the reaction [Ornithine Decarboxylase Inhibitors inhibits the reaction [HNRNPD protein binds to JUND 3' UTR]]; Putrescine inhibits the reaction [Ornithine Decarboxylase Inhibitors promotes the reaction [ELAVL1 protein binds to JUND 3' UTR]] CTD PMID:20805360 NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [Putrescine binds to TEMPO] inhibits the reaction [MPO protein results in increased chemical synthesis of Hypochlorous Acid]; [Putrescine binds to TEMPO] inhibits the reaction [MPO protein results in increased degradation of Hydrogen Peroxide]; [Putrescine binds to TEMPO] inhibits the reaction [MPO protein results in increased oxidation of Nitric Oxide]; Heparin inhibits the reaction [[Putrescine binds to TEMPO] inhibits the reaction [MPO protein results in increased chemical synthesis of Hypochlorous Acid]] CTD PMID:34085520 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression EXP Putrescine results in increased expression of MYC mRNA CTD PMID:8048943 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO [Putrescine metabolite results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide; Putrescine metabolite inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]; Putrescine metabolite inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Putrescine metabolite inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:22366099 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions
increases abundance		 EXP
ISO		 [[Ornithine Decarboxylase Inhibitors results in decreased activity of ODC1 protein] which results in decreased chemical synthesis of Polyamines] which results in decreased abundance of Putrescine; [ODC1 protein results in increased abundance of Putrescine] which affects the localization of TIA1 protein; [ODC1 protein results in increased abundance of Putrescine] which results in decreased expression of EIF3B protein; [ODC1 protein results in increased chemical synthesis of Polyamines] which results in increased abundance of Putrescine; [Pentanoic Acids results in decreased activity of ODC1 protein] which results in decreased abundance of Putrescine; Pentanoic Acids inhibits the reaction [[ODC1 protein results in increased abundance of Putrescine] which affects the localization of TIA1 protein]; Pentanoic Acids inhibits the reaction [[ODC1 protein results in increased abundance of Putrescine] which results in decreased expression of EIF3B protein] CTD PMID:20805360 PMID:22555848 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440 		JBrowse link
G Tgm2 transglutaminase 2 multiple interactions EXP Putrescine inhibits the reaction [Ethanol results in increased activity of TGM2 protein] CTD PMID:10801782 NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981 		JBrowse link
G Tia1 TIA1 cytotoxic granule-associated RNA binding protein multiple interactions EXP [ODC1 protein results in increased abundance of Putrescine] which affects the localization of TIA1 protein; Pentanoic Acids inhibits the reaction [[ODC1 protein results in increased abundance of Putrescine] which affects the localization of TIA1 protein]; Putrescine inhibits the reaction [Pentanoic Acids affects the localization of TIA1 protein] CTD PMID:22555848 NCBI chr 4:118,852,765...118,883,252
Ensembl chr 4:118,852,837...118,880,586 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20050
    role 20001
      chemical role 19530
        antioxidant 14499
          putrescine 18
            2-hydroxyputrescine 0
            N-(4-aminobutyl)dabigatranamide 0
            N-substituted putrescine + 0
            gamma-glutamylputrescine + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20050
    subatomic particle 20048
      composite particle 20048
        hadron 20048
          baryon 20048
            nucleon 20048
              atomic nucleus 20048
                atom 20048
                  main group element atom 19948
                    main group molecular entity 19948
                      s-block molecular entity 19735
                        hydrogen molecular entity 19727
                          hydrides 19093
                            inorganic hydride 17893
                              pnictogen hydride 17876
                                nitrogen hydride 17767
                                  azane 17517
                                    ammonia 17516
                                      organic amino compound 17516
                                        polyamine 8279
                                          diamine 8207
                                            primary diamine 5685
                                              alkane-alpha,omega-diamine 3764
                                                putrescine 18
                                                  2-hydroxyputrescine 0
                                                  N-(4-aminobutyl)dabigatranamide 0
                                                  N-substituted putrescine + 0
                                                  gamma-glutamylputrescine + 0
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