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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:putrescine
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Accession:CHEBI:17148 term browser browse the term
Definition:A four-carbon alkane-alpha,omega-diamine. It is obtained by the breakdown of amino acids and is responsible for the foul odour of putrefying flesh.
Synonyms:related_synonym: 1,4-Butanediamine;   1,4-DIAMINOBUTANE;   1,4-butylenediamine;   1,4-tetramethylenediamine;   Butane-1,4-diamine;   Formula=C4H12N2;   H2N(CH2)4NH2;   InChI=1S/C4H12N2/c5-3-1-2-4-6/h1-6H2;   InChIKey=KIDHWZJUCRJVML-UHFFFAOYSA-N;   Putrescin;   Putreszin;   SMILES=NCCCCN;   Tetramethylendiamin;   Tetramethylenediamine;   butylenediamine;   putrescina
 alt_id: CHEBI:14972;   CHEBI:26405;   CHEBI:45092;   CHEBI:8650
 xref: BPDB:1393;   Beilstein:605282;   CAS:110-60-1;   DrugBank:DB01917;   ECMDB:ECMDB01414;   Gmelin:1715;   HMDB:HMDB0001414;   KEGG:C00134;   KNApSAcK:C00001428
 xref_mesh: MESH:D011700
 xref: MetaCyc:PUTRESCINE;   PDBeChem:PUT;   PMID:12053479;   PMID:15453685;   PMID:16346523;   PMID:18721677;   PMID:22735334;   PMID:24331418;   PMID:24820075;   PMID:24864091;   Reaxys:605282;   Wikipedia:Putrescine;   YMDB:YMDB00132
 cyclic_relationship: is_conjugate_base_of CHEBI:326268


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putrescine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 multiple interactions ISO Putrescine binds to and results in increased activity of ADRB1 protein CTD PMID:20885010 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions ISO Putrescine binds to and results in increased activity of ADRB2 protein CTD PMID:20885010 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Amd1 adenosylmethionine decarboxylase 1 multiple interactions ISO [Sulindac co-treated with Putrescine] results in decreased activity of AMD1 protein CTD PMID:17474863 NCBI chr20:45,384,000...45,399,694
Ensembl chr20:45,384,000...45,399,694
JBrowse link
G Aoc1 amine oxidase, copper containing 1 increases degradation
increases metabolic processing
multiple interactions
ISO
EXP
AOC1 protein results in increased degradation of Putrescine
AOC1 protein results in increased metabolism of Putrescine
Amiloride inhibits the reaction [AOC1 protein results in increased degradation of Putrescine]; ethylisopropylamiloride inhibits the reaction [AOC1 protein results in increased degradation of Putrescine]; phenylamil inhibits the reaction [AOC1 protein results in increased degradation of Putrescine]; pimagedine inhibits the reaction [AOC1 protein results in increased degradation of Putrescine]
CTD PMID:1644166 PMID:8144586 PMID:12072962 NCBI chr 4:78,496,043...78,515,582
Ensembl chr 4:78,496,043...78,515,584
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression EXP Putrescine results in decreased expression of BCL2 protein CTD PMID:17606387 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 increases expression EXP Putrescine results in increased expression of CASP3 protein CTD PMID:17606387 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases expression EXP Putrescine results in increased expression of CASP9 protein CTD PMID:17606387 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Eif3b eukaryotic translation initiation factor 3, subunit B multiple interactions EXP [ODC1 protein results in increased abundance of Putrescine] which results in decreased expression of EIF3B protein; Pentanoic Acids inhibits the reaction [[ODC1 protein results in increased abundance of Putrescine] which results in decreased expression of EIF3B protein]; Putrescine inhibits the reaction [Pentanoic Acids results in increased expression of EIF3B protein] CTD PMID:22555848 NCBI chr12:16,285,730...16,310,190
Ensembl chr12:16,285,733...16,310,190
JBrowse link
G Elavl1 ELAV like RNA binding protein 1 multiple interactions EXP Putrescine inhibits the reaction [Ornithine Decarboxylase Inhibitors affects the localization of ELAVL1 protein]; Putrescine inhibits the reaction [Ornithine Decarboxylase Inhibitors promotes the reaction [ELAVL1 protein binds to JUND 3' UTR]] CTD PMID:20805360 NCBI chr12:2,461,502...2,502,432
Ensembl chr12:2,461,502...2,502,432
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Putrescine results in increased expression of FOS mRNA CTD PMID:8048943 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Hnrnpd heterogeneous nuclear ribonucleoprotein D multiple interactions EXP Putrescine inhibits the reaction [Ornithine Decarboxylase Inhibitors inhibits the reaction [HNRNPD protein binds to JUND 3' UTR]] CTD PMID:20805360 NCBI chr14:11,256,163...11,274,684
Ensembl chr14:11,256,268...11,274,578
JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Putrescine inhibits the reaction [Ornithine Decarboxylase Inhibitors inhibits the reaction [HNRNPD protein binds to JUND 3' UTR]]; Putrescine inhibits the reaction [Ornithine Decarboxylase Inhibitors promotes the reaction [ELAVL1 protein binds to JUND 3' UTR]] CTD PMID:20805360 NCBI chr16:20,485,028...20,486,707
Ensembl chr16:20,485,029...20,486,707
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression EXP Putrescine results in increased expression of MYC mRNA CTD PMID:8048943 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO [Putrescine metabolite results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide; Putrescine metabolite inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]; Putrescine metabolite inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Putrescine metabolite inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:22366099 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions
increases abundance
EXP
ISO
[[Ornithine Decarboxylase Inhibitors results in decreased activity of ODC1 protein] which results in decreased chemical synthesis of Polyamines] which results in decreased abundance of Putrescine; [ODC1 protein results in increased abundance of Putrescine] which affects the localization of TIA1 protein; [ODC1 protein results in increased abundance of Putrescine] which results in decreased expression of EIF3B protein; [ODC1 protein results in increased chemical synthesis of Polyamines] which results in increased abundance of Putrescine; [Pentanoic Acids results in decreased activity of ODC1 protein] which results in decreased abundance of Putrescine; Pentanoic Acids inhibits the reaction [[ODC1 protein results in increased abundance of Putrescine] which affects the localization of TIA1 protein]; Pentanoic Acids inhibits the reaction [[ODC1 protein results in increased abundance of Putrescine] which results in decreased expression of EIF3B protein] CTD PMID:20805360 PMID:22555848 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Tgm2 transglutaminase 2 multiple interactions EXP Putrescine inhibits the reaction [Ethanol results in increased activity of TGM2 protein] CTD PMID:10801782 NCBI chr 3:154,597,165...154,627,257
Ensembl chr 3:154,597,168...154,627,257
JBrowse link
G Tia1 TIA1 cytotoxic granule-associated RNA binding protein multiple interactions EXP [ODC1 protein results in increased abundance of Putrescine] which affects the localization of TIA1 protein; Pentanoic Acids inhibits the reaction [[ODC1 protein results in increased abundance of Putrescine] which affects the localization of TIA1 protein]; Putrescine inhibits the reaction [Pentanoic Acids affects the localization of TIA1 protein] CTD PMID:22555848 NCBI chr 4:118,207,845...118,238,246
Ensembl chr 4:118,207,862...118,235,218
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19720
      chemical role 19260
        antioxidant 14254
          putrescine 17
            N-(4-aminobutyl)dabigatranamide 0
            N-substituted putrescine + 0
            gamma-glutamylputrescine + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    main group molecular entity 19662
                      s-block molecular entity 19429
                        hydrogen molecular entity 19423
                          hydrides 18758
                            inorganic hydride 17453
                              pnictogen hydride 17428
                                nitrogen hydride 17272
                                  azane 17003
                                    ammonia 17002
                                      organic amino compound 17001
                                        polyamine 8259
                                          diamine 8186
                                            primary diamine 5659
                                              alkane-alpha,omega-diamine 3753
                                                putrescine 17
                                                  N-(4-aminobutyl)dabigatranamide 0
                                                  N-substituted putrescine + 0
                                                  gamma-glutamylputrescine + 0
paths to the root