|
G |
Adipor2 |
adiponectin receptor 2 |
increases expression |
EXP |
dietary cysteamine increases expression of adipor2 mRNA in soleus muscle and retroperitoneal adipose tissue |
RGD |
PMID:17696487 |
RGD:21079417 |
NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355
|
|
G |
Ctsd |
cathepsin D |
increases expression multiple interactions |
EXP |
Cysteamine results in increased expression of CTSD protein Omeprazole inhibits the reaction [Cysteamine results in increased expression of CTSD protein]; thamira parpam inhibits the reaction [Cysteamine results in increased expression of CTSD protein] |
CTD |
PMID:20165931 |
|
NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
|
|
G |
Cyp7a1 |
cytochrome P450 family 7 subfamily A member 1 |
increases activity |
EXP |
Cysteamine results in increased activity of CYP7A1 protein |
CTD |
PMID:1175606 |
|
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
|
|
G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
decreases activity multiple interactions |
ISO |
Cysteamine results in decreased activity of GCLC protein [Cysteamine results in decreased activity of GCLC protein] which results in decreased abundance of Glutathione |
CTD |
PMID:15282320 |
|
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
|
|
G |
Ghrl |
ghrelin and obestatin prepropeptide |
decreases expression multiple interactions |
EXP |
Cysteamine results in decreased expression of GHRL mRNA; Cysteamine results in decreased expression of GHRL protein Cysteamine results in increased expression of and results in increased secretion of GHRL protein |
CTD |
PMID:15778430 |
|
NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621
|
|
G |
Hmox1 |
heme oxygenase 1 |
increases expression multiple interactions |
EXP |
[Cysteamine results in increased expression of HMOX1] which results in increased expression of SOD2; Cysteamine results in increased expression of HMOX1 mRNA; Cysteamine results in increased expression of HMOX1 protein [stannous mesoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [Cysteamine results in increased expression of SOD2 protein] |
CTD |
PMID:10942521 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
|
|
G |
Mmp12 |
matrix metallopeptidase 12 |
increases expression |
ISO |
Cysteamine results in increased expression of MMP12 mRNA; Cysteamine results in increased expression of MMP12 protein |
CTD |
PMID:22532830 |
|
NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611
|
|
G |
Mmp14 |
matrix metallopeptidase 14 |
increases expression |
ISO |
Cysteamine results in increased expression of MMP14 mRNA; Cysteamine results in increased expression of MMP14 protein |
CTD |
PMID:22532830 |
|
NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
|
|
G |
Mmp9 |
matrix metallopeptidase 9 |
decreases activity multiple interactions increases expression |
ISO |
Cysteamine results in decreased activity of MMP9 protein Cysteamine results in increased expression of and results in decreased activity of MMP9 protein Cysteamine results in increased expression of MMP9 mRNA |
CTD |
PMID:22532830 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
|
|
G |
Mpo |
myeloperoxidase |
multiple interactions increases expression |
EXP |
geraniol inhibits the reaction [Cysteamine results in increased expression of MPO protein]; Omeprazole inhibits the reaction [Cysteamine results in increased expression of MPO protein]; thamira parpam inhibits the reaction [Cysteamine results in increased expression of MPO protein] |
CTD |
PMID:20165931 PMID:24337826 |
|
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
|
|
G |
Sod2 |
superoxide dismutase 2 |
increases expression multiple interactions |
EXP |
[Cysteamine results in increased expression of HMOX1] which results in increased expression of SOD2; Cysteamine results in increased expression of SOD2 mRNA; Cysteamine results in increased expression of SOD2 protein [stannous mesoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [Cysteamine results in increased expression of SOD2 protein] |
CTD |
PMID:10942521 |
|
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
|
|
G |
Sst |
somatostatin |
decreases expression |
EXP |
Cysteamine results in decreased expression of SST protein |
CTD |
PMID:15778430 |
|
NCBI chr11:76,956,896...76,958,173
Ensembl chr11:76,956,896...76,958,173
|
|
G |
Vnn1 |
vanin 1 |
increases chemical synthesis multiple interactions |
ISO |
VNN1 results in increased chemical synthesis of Cysteamine Cysteamine inhibits the reaction [VNN1 gene mutant form results in decreased susceptibility to Paraquat] |
CTD |
PMID:11042271 PMID:15282320 |
|
NCBI chr 1:21,537,084...21,547,395
Ensembl chr 1:21,537,094...21,547,395
|
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO |
[Amifostine co-treated with Doxorubicin] results in increased expression of BAX mRNA |
CTD |
PMID:15985719 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
[Amifostine co-treated with Doxorubicin] results in decreased expression of BCL2 mRNA |
CTD |
PMID:15985719 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
|
|
G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
[Amifostine co-treated with Doxorubicin] results in increased activity of CASP3 protein; Amifostine inhibits the reaction [Idarubicin results in increased activity of CASP3 protein]; Amifostine promotes the reaction [Idarubicin results in increased activity of CASP3 protein] |
CTD |
PMID:15985719 PMID:18438337 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Cdk1 |
cyclin-dependent kinase 1 |
decreases phosphorylation multiple interactions |
ISO |
Amifostine results in decreased phosphorylation of CDK1 protein olomoucine inhibits the reaction [TP53 protein promotes the reaction [Amifostine results in decreased phosphorylation of CDK1 protein]]; TP53 protein promotes the reaction [Amifostine results in decreased phosphorylation of CDK1 protein] |
CTD |
PMID:16628227 |
|
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
|
|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
decreases expression increases expression |
ISO |
Amifostine results in decreased expression of CDKN1A mRNA Amifostine results in increased expression of CDKN1A protein |
CTD |
PMID:12618886 PMID:14555708 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
|
|
G |
Ei24 |
EI24, autophagy associated transmembrane protein |
decreases expression |
ISO |
Amifostine results in decreased expression of EI24 mRNA |
CTD |
PMID:14555708 |
|
NCBI chr 8:36,494,289...36,510,653
Ensembl chr 8:36,494,289...36,510,571
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
Amifostine inhibits the reaction [IL6 protein results in increased phosphorylation of MYL2 protein] |
CTD |
PMID:19010997 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Mapk14 |
mitogen activated protein kinase 14 |
multiple interactions |
ISO |
Amifostine inhibits the reaction [Lipopolysaccharides results in increased activity of and results in increased phosphorylation of MAPK14 protein] |
CTD |
PMID:19010997 |
|
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
|
|
G |
Mdm2 |
MDM2 proto-oncogene |
decreases expression |
ISO |
Amifostine results in decreased expression of MDM2 mRNA |
CTD |
PMID:14555708 |
|
NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
|
|
G |
Mpo |
myeloperoxidase |
multiple interactions |
ISO |
Amifostine inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein] |
CTD |
PMID:19010997 |
|
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
|
|
G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
multiple interactions |
ISO |
[Amifostine co-treated with TP53] results in increased expression of MYC mRNA |
CTD |
PMID:14555708 |
|
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
|
|
G |
Myl2 |
myosin light chain 2 |
multiple interactions |
ISO |
Amifostine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MYL2 protein] Amifostine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MYL2 protein]; Amifostine inhibits the reaction [IL6 protein results in increased phosphorylation of MYL2 protein] |
CTD |
PMID:19010997 |
|
NCBI chr12:34,454,223...34,468,554
Ensembl chr12:34,454,218...34,468,983
|
|
G |
Nfkbia |
NFKB inhibitor alpha |
decreases expression multiple interactions |
ISO |
Amifostine results in decreased expression of NFKBIA protein Amifostine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:10590050 PMID:19010997 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
|
|
G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions |
ISO |
Amifostine inhibits the reaction [Benzene results in decreased expression of PCNA protein] |
CTD |
PMID:17661222 |
|
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions increases localization |
ISO |
Amifostine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] Amifostine results in increased localization of RELA protein |
CTD |
PMID:10590050 PMID:19010997 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
|
|
G |
Tp53 |
tumor protein p53 |
multiple interactions increases expression affects response to substance increases activity |
ISO |
[Amifostine co-treated with TP53] results in increased expression of MYC mRNA; olomoucine inhibits the reaction [TP53 protein promotes the reaction [Amifostine results in decreased phosphorylation of CDK1 protein]]; TP53 protein promotes the reaction [Amifostine results in decreased phosphorylation of CDK1 protein] Amifostine results in increased expression of TP53 protein TP53 affects the susceptibility to Amifostine Amifostine results in increased activity of TP53 protein |
CTD |
PMID:12618886 PMID:14555708 PMID:16628227 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
|
|
G |
Tp53i3 |
tumor protein p53 inducible protein 3 |
decreases expression |
ISO |
Amifostine results in decreased expression of TP53I3 mRNA |
CTD |
PMID:14555708 |
|
NCBI chr 6:27,818,327...27,825,753
|
|
|
G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
EXP |
Cystamine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; Cystamine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] |
CTD |
PMID:17708605 |
|
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
|
|
G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions |
EXP |
Cystamine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA] |
CTD |
PMID:17708605 |
|
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
|
|
G |
Tgm2 |
transglutaminase 2 |
multiple interactions |
EXP |
Cystamine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGM2 mRNA]; Cystamine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGM2 protein] |
CTD |
PMID:17708605 |
|
NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981
|
|
G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
multiple interactions |
EXP |
Cystamine inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 mRNA] |
CTD |
PMID:17708605 |
|
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
|
|
|
G |
Egfr |
epidermal growth factor receptor |
decreases phosphorylation |
ISO |
2-acetamidoethanethiol analog results in decreased phosphorylation of EGFR protein |
CTD |
PMID:20058253 |
|
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
|
|
G |
Erbb2 |
erb-b2 receptor tyrosine kinase 2 |
multiple interactions |
ISO |
2-acetamidoethanethiol analog results in decreased activity of and results in decreased phosphorylation of ERBB2 protein |
CTD |
PMID:20058253 |
|
NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
|
|
G |
Erbb3 |
erb-b2 receptor tyrosine kinase 3 |
decreases phosphorylation |
ISO |
2-acetamidoethanethiol analog results in decreased phosphorylation of ERBB3 protein |
CTD |
PMID:20058253 |
|
NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525
|
|
|
G |
Cat |
catalase |
increases expression |
ISO |
N-(2-mercaptoethyl)-1,3-diaminopropane results in increased expression of CAT protein |
CTD |
PMID:17388698 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
|
|
G |
Ccl5 |
C-C motif chemokine ligand 5 |
increases expression |
ISO |
N-(2-mercaptoethyl)-1,3-diaminopropane results in increased expression of CCL5 mRNA |
CTD |
PMID:12007958 |
|
NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
|
|
G |
Gstp1 |
glutathione S-transferase pi 1 |
decreases expression |
ISO |
N-(2-mercaptoethyl)-1,3-diaminopropane results in decreased expression of GSTP1 mRNA |
CTD |
PMID:12007958 |
|
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
|
|
G |
Il2ra |
interleukin 2 receptor subunit alpha |
increases expression |
ISO |
N-(2-mercaptoethyl)-1,3-diaminopropane results in increased expression of IL2RA mRNA |
CTD |
PMID:12007958 |
|
NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697
|
|
G |
Myb |
MYB proto-oncogene, transcription factor |
increases expression |
ISO |
N-(2-mercaptoethyl)-1,3-diaminopropane results in increased expression of MYB mRNA |
CTD |
PMID:12007958 |
|
NCBI chr 1:15,939,771...15,973,367
Ensembl chr 1:15,939,761...15,973,057
|
|
G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
decreases expression |
ISO |
N-(2-mercaptoethyl)-1,3-diaminopropane results in decreased expression of MYC mRNA |
CTD |
PMID:12007958 |
|
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
|
|
G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
N-(2-mercaptoethyl)-1,3-diaminopropane results in increased activity of [NFKB1 protein binds to RELA protein]; N-(2-mercaptoethyl)-1,3-diaminopropane results in increased activity of [RELA protein binds to NFKB1 protein] |
CTD |
PMID:11390188 PMID:11917294 PMID:12007958 |
|
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
N-(2-mercaptoethyl)-1,3-diaminopropane results in increased activity of [NFKB1 protein binds to RELA protein]; N-(2-mercaptoethyl)-1,3-diaminopropane results in increased activity of [RELA protein binds to NFKB1 protein] |
CTD |
PMID:11390188 PMID:11917294 PMID:12007958 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
|
|
G |
Sod2 |
superoxide dismutase 2 |
increases expression increases activity multiple interactions |
ISO |
N-(2-mercaptoethyl)-1,3-diaminopropane results in increased expression of SOD2 mRNA; N-(2-mercaptoethyl)-1,3-diaminopropane results in increased expression of SOD2 protein N-(2-mercaptoethyl)-1,3-diaminopropane results in increased activity of SOD2 [TNFRSF1A protein co-treated with TNFRSF1B protein] affects the reaction [N-(2-mercaptoethyl)-1,3-diaminopropane results in increased activity of SOD2]; TNFRSF1A protein affects the reaction [N-(2-mercaptoethyl)-1,3-diaminopropane results in increased activity of SOD2] helenalin inhibits the reaction [N-(2-mercaptoethyl)-1,3-diaminopropane results in increased expression of SOD2 protein]; N-(2-mercaptoethyl)-1,3-diaminopropane results in increased expression of and results in increased activity of SOD2 protein |
CTD |
PMID:11390188 PMID:11917294 PMID:12007958 PMID:16540396 PMID:17388698 PMID:21945096 More...
|
|
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
|
|
G |
Tnfrsf1a |
TNF receptor superfamily member 1A |
multiple interactions |
ISO |
[TNFRSF1A protein co-treated with TNFRSF1B protein] affects the reaction [N-(2-mercaptoethyl)-1,3-diaminopropane results in increased activity of SOD2]; TNFRSF1A protein affects the reaction [N-(2-mercaptoethyl)-1,3-diaminopropane results in increased activity of SOD2] |
CTD |
PMID:21945096 |
|
NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
|
|
G |
Tnfrsf1b |
TNF receptor superfamily member 1B |
multiple interactions |
ISO |
[TNFRSF1A protein co-treated with TNFRSF1B protein] affects the reaction [N-(2-mercaptoethyl)-1,3-diaminopropane results in increased activity of SOD2] |
CTD |
PMID:21945096 |
|
NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206
|
|