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G |
Bax |
BCL2 associated X, apoptosis regulator |
decreases expression |
EXP |
falcarinol results in decreased expression of BAX protein |
CTD |
PMID:19800326 |
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NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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G |
Bcl2 |
BCL2, apoptosis regulator |
increases expression |
EXP |
falcarinol results in increased expression of BCL2 protein |
CTD |
PMID:19800326 |
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NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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G |
Casp3 |
caspase 3 |
multiple interactions decreases expression |
EXP |
falcarinol results in decreased expression of and results in decreased activity of CASP3 protein falcarinol results in decreased expression of CASP3 protein modified form |
CTD |
PMID:19800326 |
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NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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G |
Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions |
EXP |
falcarinol inhibits the reaction [PDGFB protein results in increased phosphorylation of CREB1 protein] |
CTD |
PMID:18199429 |
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NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
increases expression |
EXP |
falcarinol results in increased expression of HIF1A protein |
CTD |
PMID:19800326 |
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NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
EXP |
falcarinol inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:18199429 |
|
NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
EXP |
falcarinol inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:18199429 |
|
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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G |
Pdgfb |
platelet derived growth factor subunit B |
multiple interactions |
EXP |
falcarinol inhibits the reaction [PDGFB protein results in increased phosphorylation of CREB1 protein]; falcarinol inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]; falcarinol inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:18199429 |
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NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
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G |
Aifm1 |
apoptosis inducing factor, mitochondria associated 1 |
multiple interactions |
ISO |
[perifosine co-treated with Butyrates] results in increased secretion of AIFM1 protein; [perifosine co-treated with trichostatin A] results in increased secretion of AIFM1 protein; [perifosine co-treated with vorinostat] results in increased secretion of AIFM1 protein |
CTD |
PMID:15781658 |
|
NCBI chr X:135,304,063...135,343,062
Ensembl chr X:135,304,066...135,343,087
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions decreases phosphorylation |
ISO |
[perifosine co-treated with Butyrates] results in decreased activity of AKT1 protein; [perifosine co-treated with trichostatin A] results in decreased activity of AKT1 protein; [perifosine co-treated with Vorinostat] results in decreased activity of AKT1 protein; AKT1 protein modified form results in decreased activity of [perifosine co-treated with Butyrates]; AKT1 protein modified form results in decreased activity of [perifosine co-treated with trichostatin A]; AKT1 protein modified form results in decreased activity of [perifosine co-treated with Vorinostat]; perifosine inhibits the reaction [cyadox results in increased phosphorylation of AKT1 protein] perifosine results in decreased phosphorylation of AKT1 protein [perifosine co-treated with temsirolimus] results in decreased activity of AKT1 protein |
CTD |
PMID:15781658 PMID:21267448 PMID:30265530 PMID:31445927 |
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NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
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G |
Bak1 |
BCL2-antagonist/killer 1 |
multiple interactions |
ISO |
[perifosine co-treated with Butyrates] results in decreased expression of BAK1 protein; [perifosine co-treated with trichostatin A] results in decreased expression of BAK1 protein; [perifosine co-treated with vorinostat] results in decreased expression of BAK1 protein |
CTD |
PMID:15781658 |
|
NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO |
[perifosine co-treated with Butyrates] results in increased activity of BAX protein; [perifosine co-treated with trichostatin A] results in increased activity of BAX protein; [perifosine co-treated with vorinostat] results in increased activity of BAX protein |
CTD |
PMID:15781658 |
|
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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G |
Casp3 |
caspase 3 |
multiple interactions decreases expression |
ISO |
[perifosine co-treated with Butyrates] results in increased activity of CASP3 protein; [perifosine co-treated with trichostatin A] results in increased activity of CASP3 protein; [perifosine co-treated with vorinostat] results in increased activity of CASP3 protein perifosine results in decreased expression of CASP3 protein |
CTD |
PMID:15781658 PMID:25416439 |
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NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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G |
Casp8 |
caspase 8 |
multiple interactions |
ISO |
[perifosine co-treated with Butyrates] results in increased activity of CASP8 protein; [perifosine co-treated with trichostatin A] results in increased activity of CASP8 protein; [perifosine co-treated with vorinostat] results in increased activity of CASP8 protein |
CTD |
PMID:15781658 |
|
NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
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G |
Cycs |
cytochrome c, somatic |
multiple interactions |
ISO |
[perifosine co-treated with Butyrates] affects the localization of CYCS protein; [perifosine co-treated with trichostatin A] affects the localization of CYCS protein; [perifosine co-treated with vorinostat] affects the localization of CYCS protein |
CTD |
PMID:15781658 |
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NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
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G |
Egf |
epidermal growth factor |
multiple interactions |
ISO |
perifosine inhibits the reaction [cyadox results in increased expression of EGF]; perifosine inhibits the reaction [Hydrogen Peroxide results in increased expression of EGF] |
CTD |
PMID:30265530 |
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NCBI chr 2:68,820,616...68,895,537
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G |
Fas |
Fas cell surface death receptor |
affects response to substance |
ISO |
perifosine affects the susceptibility to FAS protein |
CTD |
PMID:31445927 |
|
NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
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G |
Foxo1 |
forkhead box O1 |
multiple interactions |
ISO |
[perifosine co-treated with cyadox] results in increased expression of FOXO1 mRNA; [perifosine co-treated with Hydrogen Peroxide] results in increased expression of FOXO1 mRNA |
CTD |
PMID:30265530 |
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NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
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G |
Lat2 |
linker for activation of T cells family, member 2 |
multiple interactions decreases expression decreases response to substance |
ISO |
ixazomib inhibits the reaction [perifosine results in decreased expression of LAT2 protein] LAT2 protein results in decreased susceptibility to perifosine |
CTD |
PMID:23001822 |
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NCBI chr12:25,114,099...25,128,381
Ensembl chr12:25,119,355...25,125,749
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G |
Map2k1 |
mitogen activated protein kinase kinase 1 |
multiple interactions |
ISO |
MAP2K1 protein mutant form results in decreased activity of [perifosine co-treated with Butyrates]; MAP2K1 protein mutant form results in decreased activity of [perifosine co-treated with trichostatin A]; MAP2K1 protein mutant form results in decreased activity of [perifosine co-treated with vorinostat] |
CTD |
PMID:15781658 |
|
NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
[perifosine co-treated with Butyrates] results in decreased activity of MAPK1 protein; [perifosine co-treated with trichostatin A] results in decreased activity of MAPK1 protein; [perifosine co-treated with vorinostat] results in decreased activity of MAPK1 protein |
CTD |
PMID:15781658 |
|
NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
[perifosine co-treated with Butyrates] results in decreased activity of MAPK3 protein; [perifosine co-treated with trichostatin A] results in decreased activity of MAPK3 protein; [perifosine co-treated with vorinostat] results in decreased activity of MAPK3 protein |
CTD |
PMID:15781658 |
|
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO |
[perifosine co-treated with Butyrates] results in increased activity of MAPK8 protein; [perifosine co-treated with trichostatin A] results in increased activity of MAPK8 protein; [perifosine co-treated with vorinostat] results in increased activity of MAPK8 protein |
CTD |
PMID:15781658 |
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NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
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G |
Mtor |
mechanistic target of rapamycin kinase |
multiple interactions |
ISO |
[perifosine co-treated with temsirolimus] results in decreased activity of MTOR protein |
CTD |
PMID:21267448 |
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NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
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G |
Tnf |
tumor necrosis factor |
increases response to substance |
ISO |
perifosine results in increased susceptibility to TNF protein |
CTD |
PMID:31445927 |
|
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
perifosine inhibits the reaction [cyadox results in increased expression of TP53 mRNA]; perifosine inhibits the reaction [cyadox results in increased expression of TP53 protein]; perifosine inhibits the reaction [Hydrogen Peroxide results in increased expression of TP53 mRNA] |
CTD |
PMID:30265530 |
|
NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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G |
Aldh3a2 |
aldehyde dehydrogenase 3 family, member A2 |
increases expression multiple interactions |
ISO |
Phytol results in increased expression of ALDH3A2 protein PPARA protein affects the reaction [Phytol results in increased expression of ALDH3A2 protein] |
CTD |
PMID:17015885 |
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NCBI chr10:47,525,486...47,546,535
Ensembl chr10:47,525,493...47,546,345
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO |
Phytol inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX protein] |
CTD |
PMID:30520250 |
|
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
Phytol inhibits the reaction [Benzo(a)pyrene results in decreased expression of BCL2 protein] |
CTD |
PMID:30520250 |
|
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
Phytol inhibits the reaction [Benzo(a)pyrene results in increased expression of CASP3 protein] |
CTD |
PMID:30520250 |
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NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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G |
Casp9 |
caspase 9 |
multiple interactions |
ISO |
[Phytol co-treated with Benzo(a)pyrene] results in decreased expression of CASP9 protein |
CTD |
PMID:30520250 |
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NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
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G |
Cat |
catalase |
increases expression multiple interactions |
ISO |
Phytol results in increased expression of CAT Phytol inhibits the reaction [Benzo(a)pyrene results in increased expression of CAT protein] |
CTD |
PMID:19188468 PMID:30520250 |
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NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
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G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
ISO |
Phytol inhibits the reaction [Benzo(a)pyrene results in increased expression of GSR protein] |
CTD |
PMID:30520250 |
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NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK1 protein]]; Acetylcysteine affects the reaction [Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK1 protein]]; Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:29486182 |
|
NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK3 protein]]; Acetylcysteine affects the reaction [Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK3 protein]]; Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:29486182 |
|
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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G |
Mitf |
melanocyte inducing transcription factor |
multiple interactions |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]] which results in decreased ubiquitination of MITF protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]]; [Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]] which results in decreased ubiquitination of MITF protein; Acetylcysteine inhibits the reaction [Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]] which results in decreased ubiquitination of MITF protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]]; Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein] |
CTD |
PMID:29486182 |
|
NCBI chr 4:130,172,484...130,425,496
Ensembl chr 4:130,172,727...130,425,532
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
affects metabolic processing multiple interactions |
ISO |
PPARA protein affects the metabolism of Phytol PPARA protein affects the reaction [Phytol results in increased expression of ALDH3A2 protein] |
CTD |
PMID:17015885 |
|
NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
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G |
Ppargc1b |
PPARG coactivator 1 beta |
increases activity |
ISO |
Phytol results in increased activity of PPARGC1B protein |
CTD |
PMID:17015885 |
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NCBI chr18:56,626,725...56,650,524
Ensembl chr18:56,626,712...56,728,968
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G |
Tyr |
tyrosinase |
multiple interactions |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytol inhibits the reaction [alpha-MSH results in increased expression of TYR protein]]; Phytol inhibits the reaction [alpha-MSH results in increased expression of TYR protein] |
CTD |
PMID:29486182 |
|
NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802
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G |
Tyrp1 |
tyrosinase-related protein 1 |
multiple interactions |
ISO |
Phytol inhibits the reaction [alpha-MSH results in increased expression of TYRP1 protein] |
CTD |
PMID:29486182 |
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NCBI chr 5:98,387,291...98,406,083
Ensembl chr 5:98,387,291...98,406,083
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