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ONTOLOGY REPORT - ANNOTATIONS


Term:carnitine
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Accession:CHEBI:17126 term browser browse the term
Definition:An amino-acid betaine that is butanoate substituted with a hydroxy group at position C-3 and a trimethylammonium group at C-4.
Synonyms:exact_synonym: 3-hydroxy-4-(trimethylammonio)butanoate
 related_synonym: D,L-carnitine;   Formula=C7H15NO3;   InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3;   InChIKey=PHIQHXFUZVPYII-UHFFFAOYSA-N;   SMILES=C[N+](C)(C)CC(O)CC([O-])=O
 alt_id: CHEBI:11817;   CHEBI:13947;   CHEBI:20047;   CHEBI:23038
 xref: Beilstein:1866665 "Beilstein";   CAS:461-06-3 "ChemIDplus";   DrugBank:DB02648;   KEGG:C00487;   MetaCyc:DL-CARNITINE;   PMID:22770225 "Europe PMC";   PMID:23868375 "Europe PMC";   Patent:US4255449;   Patent:US4315944;   Reaxys:1866665 "Reaxys";   Wikipedia:Carnitine
 cyclic_relationship: is_conjugate_base_of CHEBI:3424


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(R)-carnitine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adipoq adiponectin, C1Q and collagen domain containing JBrowse link 11 81,330,845 81,344,488 RGD:6480464
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bbox1 gamma-butyrobetaine hydroxylase 1 JBrowse link 3 101,425,684 101,474,848 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6480464
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:6480464
G Ccn2 cellular communication network factor 2 JBrowse link 1 21,851,657 21,854,773 RGD:6480464
G Cdh1 cadherin 1 JBrowse link 19 38,768,467 38,838,395 RGD:6480464
G Col1a1 collagen type I alpha 1 chain JBrowse link 10 82,745,801 82,762,790 RGD:6480464
G Col2a1 collagen type II alpha 1 chain JBrowse link 7 139,454,945 139,484,403 RGD:6480464
G Cpt1a carnitine palmitoyltransferase 1A JBrowse link 1 218,568,157 218,629,679 RGD:6480464
G Cpt2 carnitine palmitoyltransferase 2 JBrowse link 5 127,505,646 127,523,016 RGD:6480464
G Cybb cytochrome b-245 beta chain JBrowse link X 14,578,330 14,610,049 RGD:6480464
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 JBrowse link 1 213,511,892 213,522,195 RGD:6480464
G Fabp3 fatty acid binding protein 3 JBrowse link 5 148,528,854 148,535,597 RGD:6480464
G Gpx1 glutathione peroxidase 1 JBrowse link 8 117,117,430 117,118,528 RGD:6480464
G Hrk harakiri, BCL2 interacting protein JBrowse link 12 44,008,879 44,029,211 RGD:6480464
G Hspa2 heat shock protein family A (Hsp70) member 2 JBrowse link 6 99,433,575 99,436,288 RGD:6480464
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 JBrowse link 1 141,874,354 141,893,674 RGD:6480464
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Lepr leptin receptor JBrowse link 5 120,503,475 120,682,281 RGD:6480464
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:6480464
G Mpo myeloperoxidase JBrowse link 10 75,087,892 75,098,260 RGD:6480464
G Mt-co1 mitochondrially encoded cytochrome c oxidase I JBrowse link MT 5,323 6,867 RGD:6480464
G Mt-nd6 mitochondrially encoded NADH dehydrogenase 6 JBrowse link MT 13,543 14,061 RGD:6480464
G Mttp microsomal triglyceride transfer protein JBrowse link 2 243,366,181 243,407,608 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Nos3 nitric oxide synthase 3 JBrowse link 4 7,321,908 7,342,404 RGD:6480464
G Ppara peroxisome proliferator activated receptor alpha JBrowse link 7 126,618,872 126,687,282 RGD:6480464
G Pparg peroxisome proliferator-activated receptor gamma JBrowse link 4 147,274,055 147,399,383 RGD:6480464
G Ptgis prostaglandin I2 synthase JBrowse link 3 163,950,746 163,986,129 RGD:6480464
G Slc22a4 solute carrier family 22 member 4 JBrowse link 10 39,334,972 39,373,508 RGD:6480464
G Slc22a5 solute carrier family 22 member 5 JBrowse link 10 39,201,101 39,228,090 RGD:6480464
G Slc22a8 solute carrier family 22 member 8 JBrowse link 1 224,799,444 224,818,482 RGD:6480464
G Slc25a20 solute carrier family 25 member 20 JBrowse link 8 117,455,308 117,476,762 RGD:6480464
G Slc2a4 solute carrier family 2 member 4 JBrowse link 10 56,552,921 56,558,562 RGD:6480464
G Snai1 snail family transcriptional repressor 1 JBrowse link 3 164,274,710 164,279,199 RGD:6480464
G Srebf1 sterol regulatory element binding transcription factor 1 JBrowse link 10 46,570,996 46,593,021 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6480464
G Timp1 TIMP metallopeptidase inhibitor 1 JBrowse link X 1,364,771 1,369,451 RGD:6480464
G Tjp1 tight junction protein 1 JBrowse link 1 126,146,489 126,515,359 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Vim vimentin JBrowse link 17 80,882,715 80,891,200 RGD:6480464
O-acetyl-L-carnitine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ache acetylcholinesterase JBrowse link 12 22,472,358 22,477,052 RGD:6480464
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 JBrowse link 15 27,849,943 27,852,083 RGD:6480464
G Atp6v1f ATPase H+ transporting V1 subunit F JBrowse link 4 56,744,563 56,747,657 RGD:6480464
G C1qa complement C1q A chain JBrowse link 5 155,261,254 155,264,101 RGD:6480464
G C4b complement C4B (Chido blood group) JBrowse link 20 4,302,344 4,316,752 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6480464
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:6480464
G Col2a1 collagen type II alpha 1 chain JBrowse link 7 139,454,945 139,484,403 RGD:6480464
G Ctss cathepsin S JBrowse link 2 197,655,780 197,679,768 RGD:6480464
G Cxcl14 C-X-C motif chemokine ligand 14 JBrowse link 17 9,109,731 9,117,754 RGD:6480464
G Egr1 early growth response 1 JBrowse link 18 27,657,903 27,660,101 RGD:6480464
G Gfap glial fibrillary acidic protein JBrowse link 10 90,990,762 90,999,435 RGD:6480464
G Gsr glutathione-disulfide reductase JBrowse link 16 62,197,617 62,239,987 RGD:6480464
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Hmox2 heme oxygenase 2 JBrowse link 10 10,990,034 11,035,493 RGD:6480464
G Hspb1 heat shock protein family B (small) member 1 JBrowse link 12 23,839,390 23,841,051 RGD:6480464
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 JBrowse link 1 141,874,354 141,893,674 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Mgst1 microsomal glutathione S-transferase 1 JBrowse link 4 172,119,382 172,134,609 RGD:6480464
G Mt-co1 mitochondrially encoded cytochrome c oxidase I JBrowse link MT 5,323 6,867 RGD:6480464
G Ngf nerve growth factor JBrowse link 2 204,886,158 204,939,523 RGD:6480464
G Nos1 nitric oxide synthase 1 JBrowse link 12 44,214,949 44,405,530 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Pah phenylalanine hydroxylase JBrowse link 7 28,066,639 28,129,772 RGD:6480464
G Pink1 PTEN induced kinase 1 JBrowse link 5 156,677,146 156,689,258 RGD:6480464
G Ppargc1a PPARG coactivator 1 alpha JBrowse link 14 63,095,291 63,190,688 RGD:6480464
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:6480464
G Psmb6 proteasome 20S subunit beta 6 JBrowse link 10 57,131,339 57,133,685 RGD:6480464
G Ptma prothymosin alpha JBrowse link 9 93,545,396 93,549,436 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Rps17 ribosomal protein S17 JBrowse link 1 143,167,329 143,169,915 RGD:6480464
G Skap2 src kinase associated phosphoprotein 2 JBrowse link 4 81,816,778 81,968,832 RGD:6480464
G Slc25a20 solute carrier family 25 member 20 JBrowse link 8 117,455,308 117,476,762 RGD:6480464
G Snca synuclein alpha JBrowse link 4 90,782,412 90,883,236 RGD:6480464
G Tnni3 troponin I3, cardiac type JBrowse link 1 72,882,806 72,886,490 RGD:6480464
O-butanoyl-L-carnitine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 JBrowse link 1 141,874,354 141,893,674 RGD:6480464
O-octanoylcarnitine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Crot carnitine O-octanoyltransferase JBrowse link 4 22,079,837 22,116,265 RGD:6480464
O-palmitoylcarnitine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Col2a1 collagen type II alpha 1 chain JBrowse link 7 139,454,945 139,484,403 RGD:6480464
G Gls glutaminase JBrowse link 9 54,212,622 54,284,879 RGD:6480464
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha JBrowse link 14 100,311,224 100,360,879 RGD:6480464
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 JBrowse link 2 54,857,688 54,893,404 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19654
    role 19598
      biological role 19596
        biochemical role 19125
          metabolite 19093
            butyrate 80
              carnitine 80
                (11Z)-eicoseneoylcarnitine 0
                (11Z,14Z)-eicosadienoylcarnitine 0
                (13Z,16Z)-docosadienoylcarnitine 0
                (2E)-7-carboxyhept-2-enoylcarnitine 0
                (2E)-octenoylcarnitine 0
                (2E,4Z)-decadienoylcarnitine 0
                (2E,5Z,7E)-decatrienoylcarnitine 0
                (5Z)-13-carboxytridec-5-enoylcarnitine 0
                (7Z,10Z,13Z,16Z)-docosatetraenoylcarnitine 0
                (9Z)-3-hydroxydodecenoylcarnitine 0
                (9Z)-3-hydroxyoctadecenoylcarnitine 0
                (9Z,12Z,15Z)-3-hydroxyoctadecatrienoylcarnitine 0
                (R)-carnitine + 76
                (S)-carnitine + 0
                2-ethylacryloylcarnitine 0
                3-hydroxy-cis-5-octenoylcarnitine 0
                3-hydroxyarachidonoylcarnitine 0
                3-hydroxybutyrylcarnitine 0
                3-hydroxydecanoylcarnitine 0
                3-hydroxydodecanoylcarnitine 0
                3-hydroxyeicosanoylcarnitine 0
                3-hydroxyhexadecanoylcarnitine 0
                3-hydroxylinoleoylcarnitine 0
                3-hydroxyoctadecanoylcarnitine 0
                3-hydroxytetradecanoylcarnitine 0
                O-(11-carboxyundecanoyl)carnitine 0
                O-(13-carboxytridecanoyl)carnitine 0
                O-(17-carboxyheptadecanoyl)carnitine 0
                O-(4,8-dimethylnonanoyl)carnitine 0
                O-[(2E)-hexenedioyl]carnitine 0
                O-[(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl]carnitine 0
                O-[(9Z)-17-carboxyheptadec-9-enoyl]carnitine 0
                O-acetyl-L-carnitine 38
                O-acylcarnitine + 42
                O-arachidonoylcarnitine 0
                O-behenoylcarnitine 0
                O-icosanoylcarnitine 0
                O-linoleoylcarnitine 0
                O-methylmalonylcarnitine 0
                O-palmitoleoylcarnitine 0
                O-pimeloylcarnitine 0
                O-sebacoylcarnitine 0
                O-succinylcarnitine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19654
    subatomic particle 19650
      composite particle 19650
        hadron 19650
          baryon 19650
            nucleon 19650
              atomic nucleus 19650
                atom 19650
                  main group element atom 19531
                    main group molecular entity 19531
                      s-block molecular entity 19314
                        hydrogen molecular entity 19303
                          hydrides 18231
                            inorganic hydride 17095
                              pnictogen hydride 17053
                                nitrogen hydride 16874
                                  ammonium 8202
                                    ammonium ion derivative 8197
                                      quaternary ammonium ion 5050
                                        quaternary nitrogen compound 541
                                          ammonium betaine 268
                                            amino-acid betaine 182
                                              carnitine 80
                                                (11Z)-eicoseneoylcarnitine 0
                                                (11Z,14Z)-eicosadienoylcarnitine 0
                                                (13Z,16Z)-docosadienoylcarnitine 0
                                                (2E)-7-carboxyhept-2-enoylcarnitine 0
                                                (2E)-octenoylcarnitine 0
                                                (2E,4Z)-decadienoylcarnitine 0
                                                (2E,5Z,7E)-decatrienoylcarnitine 0
                                                (5Z)-13-carboxytridec-5-enoylcarnitine 0
                                                (7Z,10Z,13Z,16Z)-docosatetraenoylcarnitine 0
                                                (9Z)-3-hydroxydodecenoylcarnitine 0
                                                (9Z)-3-hydroxyoctadecenoylcarnitine 0
                                                (9Z,12Z,15Z)-3-hydroxyoctadecatrienoylcarnitine 0
                                                (R)-carnitine + 76
                                                (S)-carnitine + 0
                                                2-ethylacryloylcarnitine 0
                                                3-hydroxy-cis-5-octenoylcarnitine 0
                                                3-hydroxyarachidonoylcarnitine 0
                                                3-hydroxybutyrylcarnitine 0
                                                3-hydroxydecanoylcarnitine 0
                                                3-hydroxydodecanoylcarnitine 0
                                                3-hydroxyeicosanoylcarnitine 0
                                                3-hydroxyhexadecanoylcarnitine 0
                                                3-hydroxylinoleoylcarnitine 0
                                                3-hydroxyoctadecanoylcarnitine 0
                                                3-hydroxytetradecanoylcarnitine 0
                                                O-(11-carboxyundecanoyl)carnitine 0
                                                O-(13-carboxytridecanoyl)carnitine 0
                                                O-(17-carboxyheptadecanoyl)carnitine 0
                                                O-(4,8-dimethylnonanoyl)carnitine 0
                                                O-[(2E)-hexenedioyl]carnitine 0
                                                O-[(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl]carnitine 0
                                                O-[(9Z)-17-carboxyheptadec-9-enoyl]carnitine 0
                                                O-acetyl-L-carnitine 38
                                                O-acylcarnitine + 42
                                                O-arachidonoylcarnitine 0
                                                O-behenoylcarnitine 0
                                                O-icosanoylcarnitine 0
                                                O-linoleoylcarnitine 0
                                                O-methylmalonylcarnitine 0
                                                O-palmitoleoylcarnitine 0
                                                O-pimeloylcarnitine 0
                                                O-sebacoylcarnitine 0
                                                O-succinylcarnitine 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.